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https://www.readbyqxmd.com/read/29784631/safety-and-efficacy-of-polymer-free-biolimus-eluting-stents-in-all-comer-patients-the-rudi-free-study
#1
Gennaro Sardella, Giulio G Stefanini, Carlo Briguori, Corrado Tamburino, Franco Fabbiocchi, Francesco Rotolo, Fabrizio Tomai, Anita Paggi, Mario Lombardi, Gaetano Gioffrè, Rocco Sclafani, Andrea Rolandi, Alessandro Sciahbasi, Francesco Scardaci, Nicola Signore, Simone Calcagno, Massimo Mancone, Mauro Chiarito, Arturo Giordano
AIMS: Polymer-free biolimus-eluting stents (PF-BES) have been shown superior to bare metal stents in high bleeding risk (HBR) patients treated with 1-month dual antiplatelet therapy (DAPT). However, limited evidence is available on PF-BES in non-HBR patients. We aim to evaluate the safety and efficacy of PF-BES in all-comer patients undergoing percutaneous coronary interventions (PCI). METHODS AND RESULTS: Patients with stable coronary artery disease or acute coronary syndromes (ACS) undergoing PCI with PF-BES in routine clinical practice were included in a multicenter, prospective registry...
May 21, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29779621/inhibition-of-notch-signaling-pathway-temporally-postpones-the-cartilage-degradation-progress-of-temporomandibular-joint-arthritis-in-mice
#2
Xueting Luo, Yangmei Jiang, Ruiye Bi, Nan Jiang, Songsong Zhu
PURPOSE: The aim of this study is to explore the role of Notch signaling pathway in the initiation and progression of temporomandibular joint osteoarthritis (TMJOA). METHODS: 48 mice were divided into DAPT-TMJOA, Control-TMJOA and Control-Sham groups. Animals received discectomy/Sham surgery in their right TMJ, following the DAPT/saline intra-articular injections every week. Mice were sacrificed at 1/4/8 weeks post-surgery. Safranin-O and H&E staining were performed on the TMJ sections for the modified Mankin's score...
May 2, 2018: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29779587/meta-analysis-of-studies-comparing-dual-versus-mono-antiplatelet-therapy-following-transcatheter-aortic-valve-implantation
#3
Shadi Al Halabi, Joshua Newman, Michael E Farkouh, David Fortuin, Fred Leya, John Sweeney, Amir Darki, John Lopez, Lowell Steen, Bruce Lewis, John Webb, Martin B Leon, Verghese Mathew
Current guidelines recommend dual-antiplatelet therapy (DAPT) after transcatheter aortic valve implantation (TAVI), although some studies suggest mono-antiplatelet therapy is equally efficacious with an improved safety profile. We performed a meta-analysis of studies comparing DAPT with mono-antiplatelet therapy after TAVI. Study quality and heterogeneity were assessed using Jadad score, Newcastle-Ottawa Scale, and Cochran's Q statistics. Mantel-Haenszel odds ratios (ORs) were calculated using fixed effect models as the primary analysis...
March 28, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29778598/relevance-of-antiplatelet-therapy-duration-after-stent-assisted-coil-embolization-for-unruptured-intracranial-aneurysms
#4
Tackeun Kim, Chang Hyeun Kim, Si-Hyuck Kang, Seung Pil Ban, O-Ki Kwon
BACKGROUND: The optimal duration of dual antiplatelet therapy (DAPT) for preventing delayed thromboembolic events (DTEs) remains unclear. We aimed to determine whether longer DAPT provides improved protection against delayed DTEs. METHODS: This retrospective cohort study included 507 stent-assisted coil embolization procedures using a single stent for unruptured intracranial aneurysms. We performed coarsened exact matching according to the duration of maintenance DAPT...
May 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29764713/utility-of-grace-and-acuity-horizons-risk-scores-to-guide-dual-antiplatelet-therapy-in-korean-patients-with-acute-myocardial-infarction-undergoing-drug-eluting-stenting
#5
Doo Sun Sim, Myung Ho Jeong, Hyo Soo Kim, Hyeon Cheol Gwon, Ki Bae Seung, Seung Woon Rha, Shung Chull Chae, Chong Jin Kim, Kwang Soo Cha, Jong Sun Park, Jung Han Yoon, Jei Keon Chae, Seung Jae Joo, Dong Ju Choi, Seung Ho Hur, In Whan Seong, Myeong Chan Cho, Doo Il Kim, Seok Kyu Oh, Tae Hoon Ahn, Jin Yong Hwang
BACKGROUND: Dual antiplatelet therapy (DAPT) is recommended in patients receiving drug-eluting stents (DES). However, bleeding risk should be weighed against ischemic risk. Utility of GRACE risk score and ACUITY-HORIZONS bleeding risk score was assessed in patients with acute myocardial infarction (MI) according to use of P2Y12 blocker. METHODS: From the Korea Acute Myocardial Infarction Registry-National Institute of Health database, 7791 patients with acute MI receiving DES were divided into ticagrelor (n=1554) and clopidogrel (n=6237) groups...
May 12, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29754932/mild-hypothermia-inhibits-the-notch-3-and-notch-4-activation-and-seizure-after-stroke-in-the-rat-model
#6
Guo-Shuai Yang, Xiao-Yan Zhou, Xue-Fang An, Xuan-Jun Liu, Yan-Jun Zhang, Dan Yu
Ischemic brain injury is an important cause for seizure. Mild hypothermia of the brain or the whole body is an effective way to remit the post-stroke seizure. Our previous study revealed an implication of Notch 1 and 2 in the post-stroke seizure. This study further investigated the involvement of Notch 3 and 4 in post-stroke seizure and the effect of mild hypothermia on these two factors. A global cerebral ischemia (GCI) model was conducted in Sprague Dawley rats. Seizure activity was evaluated by the frequency of seizure attacks, seizure severity scores, and seizure discharges...
May 4, 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29713989/optimal-duration-of-dual-antiplatelet-therapy-for-coronary-artery-disease
#7
REVIEW
W J Kikkert, P Damman
The optimal duration of dual antiplatelet therapy (DAPT) for stable coronary artery disease and acute coronary syndrome is a complex decision. We review current literature on standard duration DAPT versus short duration DAPT (6 months or shorter) or extended duration DAPT (>12 months) after percutaneous coronary intervention with drug-eluting stent placement, and prolonged treatment after 12 months in acute coronary syndrome. Current guideline recommendations are summarised, including the use of risk scores for ischaemic and bleeding risk assessment...
April 30, 2018: Netherlands Heart Journal
https://www.readbyqxmd.com/read/29669424/impact-of-chronic-antiplatelet-therapy-on-infarct-size-and-bleeding-in-patients-with-acute-myocardial-infarction
#8
Jeness Campodonico, Nicola Cosentino, Valentina Milazzo, Mara Rubino, Monica De Metrio, Ivana Marana, Marco Moltrasio, Marco Grazi, Gianfranco Lauri, Alice Bonomi, Fabrizio Veglia, Elisa Chiorino, Emilio Assanelli, Antonio L Bartorelli, Giancarlo Marenzi
BACKGROUND: Patients hospitalized with acute myocardial infarction (AMI) are often on prior single antiplatelet therapy (SAPT) or a dual antiplatelet therapy (DAPT). Whether chronic SAPT or DAPT is beneficial or associated with an increased risk in AMI is still controversial. METHODS AND RESULTS: We prospectively enrolled 1718 consecutive patients with AMI (798 ST-segment elevation myocardial infarction and 920 non-ST-segment elevation myocardial infarction) who were divided according to their chronic APT (no APT, SAPT, or DAPT)...
January 1, 2018: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29602648/dual-antiplatelet-therapy-after-coronary-stent-implantation-individualizing-the-optimal-duration
#9
REVIEW
Leslie Marisol Lugo, José Luis Ferreiro
Dual antiplatelet therapy (DAPT) with a P2Y12 receptor antagonist in addition to aspirin is the antiplatelet treatment of choice in patients undergoing percutaneous coronary intervention. Despite DAPT being one of the most widely investigated treatment strategies in the cardiology field, its optimal duration after coronary stenting remains controversial. The balance between the possible benefit of preventing a thrombotic event and the risk of suffering a bleeding complication due to maintenance of therapy is of critical relevance to determine the duration of DAPT in a given patient...
March 27, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29562422/-predictive-value-of-the-grace-discharge-score-on-the-long-term-out-of-hospital-coronary-thrombotic-events-after-implantation-of-drug-eluting-stents
#10
X Y Zhao, J X Li, X F Tang, Y Xian, J J Xu, Y Song, L Jiang, L J Xu, J Chen, Y Zhang, L Song, L J Gao, Z Gao, J Zhang, Y Wu, S B Qiao, Y J Yang, R L Gao, B Xu, J Q Yuan
Objective: To evaluate the predictive value of GRACE discharge score on the long-term out-of-hospital coronary thrombotic events (CTE) after percutaneous coronary intervention (PCI) with drug-eluting stents. Methods: Present study was a prospective, observational, single center study. 10 724 consecutive patients underwent PCI in Fuwai Hospital between January and December 2013 were included, stents were implanted with conventional method. After PCI, patients were prescribed aspirin 100 mg once daily indefinitely, and either clopidogrel 75 mg once daily or ticagrelor 90 mg twice daily for at least 1 year...
March 24, 2018: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29523162/effect-of-%C3%AE-secretase-inhibitor-on-th17-cell-differentiation-and-function-of-mouse-psoriasis-like-skin-inflammation
#11
Lei Ma, Haibo Xue, Ruiqun Qi, Yanqin Wang, Libing Yuan
BACKGROUND: Th17 cells and its effective cytokine IL-17A play an important role in the pathogenesis of abnormal immune responses in psoriasis. Notch1 signaling has been implicated in Th17 cell differentiation and function. In this study, our aim was to evaluate the possible inhibitory effect of Notch1 signaling inhibitor, γ-secretase inhibitor DAPT, on psoriatic Th17 cell differentiation and function in a mouse model of psoriasis-like skin inflammation. METHODS: Mouse psoriasis-like skin inflammation model was established by topical 5% imiquimod (IMQ) application, and experimental mice were divided into control group, IMQ-treated group and IM + DAPT-treated group...
March 10, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29495217/-predictive-value-of-grace-discharge-score-for-long-term-out-of-hospital-death-in-acute-coronary-syndrome-after-percutaneous-coronary-intervention
#12
X Y Zhao, J X Li, X F Tang, J J Xu, Y Song, H H Wang, L J Xu, J Chen, Y Zhang, L Song, L J Gao, S B Qiao, Y J Yang, R L Gao, B Xu, J Q Yuan
Objective: To evaluate the prognostic value of Global Registry of Acute Coronary Events(GRACE) discharge score for long-term out-of-hospital death in acute coronary syndrome (ACS) after drug-eluting stents (DES) and with Dual-antiplatelet Therapy (DAPT). Methods: Our study was a prospective, observational, single center (Fuwai Hospital of China) study.A total of 6 431consecutive ACS patients underwent percutaneous coronary intervention(PCI)between January 2013 and December 2013 were involved.The primary endpoint was all-cause death and second endpoint was major adverse cardiovascular and cerebrovascular events (MACCE) as a composite of all-cause death, myocardial infarction, revascularization, stent thrombosis or stroke...
February 13, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29468725/a-clinical-risk-score-to-identify-patients-at-high-risk-of-very-late-stent-thrombosis
#13
Thea C Godschalk, Marieke E Gimbel, Wouter W Nolet, Dionne J van Kessel, Giovanni Amoroso, Willem J Dewilde, Joanna J Wykrzykowska, Paul W Janssen, Thomas O Bergmeijer, Johannes C Kelder, Ton Heestermans, Jurriën M Ten Berg
OBJECTIVES: The aim of this study was to determine predictors of very late stent thrombosis (VLST; >1 year after stenting), and to evaluate whether addition of these predictors to the dual antiplatelet therapy (DAPT) score would improve the ability to identify patients at high risk of VLST who might benefit from DAPT. BACKGROUND: VLST is a severe complication of percutaneous coronary intervention (PCI). Extended knowledge about the predictors of VLST is needed to prevent this life-threatening complication...
April 2018: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/29431659/validation-of-dapt-score-dual-antiplatelet-therapy-in-east-asian-patients
#14
EDITORIAL
Hiroto Yabushita, Shinya Goto
No abstract text is available yet for this article.
February 6, 2018: Circulation
https://www.readbyqxmd.com/read/29350390/dual-antiplatelet-therapy-is-safe-and-efficient-after-left-atrial-appendage-closure
#15
Jakub Maksym, Tomasz Mazurek, Janusz Kochman, Marek Grygier, Agnieszka Kapłon-Cieślicka, Michał Marchel, Piotr Lodziński, Radosław Piątkowski, Radosław Wilimski, Paweł Czub, Anna Fojt, Natalia Karolczak, Piotr Hendzel, Grzegorz Opolski
BACKGROUND: Despite results of the PROTECT AF trial, many patients undergoing left atrial appendage closure (LAAC) have unconditional contraindications to warfarin. AIM: We sought to investigate whether double antiplatelet therapy (DAPT) is safe in patients after LAAC. METHODS: Forty-four consecutive patients (22 males, mean age 74 ± 7.8 years) with non-valvular atrial fibrillation (NVAF) underwent LAAC procedure using a Watchman device followed by DAPT (75 mg/d aspirin and 75 mg/d clopidogrel)...
2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29322612/validation-of-contemporary-risk-scores-in-predicting-coronary-thrombotic-events-and-major-bleeding-in-patients-with-acute-coronary-syndrome-after-drug-eluting-stent-implantations
#16
Li Song, Changdong Guan, Hongbing Yan, Shubin Qiao, Yongjian Wu, Jinqing Yuan, Kefei Dou, Yuejin Yang, George D Dangas, Bo Xu
OBJECTIVES: We aimed to assess the prognostic ability of the ST score, DAPT score, and PARIS score in a Chinese population. BACKGROUND: Recently, several risk scores predicting the long-term risk of coronary thrombotic events [CTE, defined as the composite of definite or probable stent thrombosis (ST) and myocardial infarction] and bleeding have been developed and initially validated in Western populations. METHODS: A total of 6,088 consecutive patients with acute coronary syndrome (mean age 58...
February 15, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29313819/real-world-safety-and-efficacy-of-watchman-laa-closure-at-one-year-in-patients-on-dual-antiplatelet-therapy-results-of-the-dapt-subgroup-from-the-ewolution-all-comers-study
#17
Martin W Bergmann, Hüseyin Ince, Stephan Kische, Thomas Schmitz, Felix Meincke, Boris Schmidt, David Foley, Timothy R Betts, Marek Grygier, Alexey V Protopopov, Kenneth M Stein, Lucas V A Boersma
AIMS: The study aims to confirm efficacy and safety of WATCHMAN LAA closure in AF patients unsuitable for oral anticoagulation. METHODS AND RESULTS: The EWOLUTION registry prospectively collects all clinical data on 1005 European patients implanted with a WATCHMAN device. Following the procedure, 605 patients (60.2%) received dual antiplatelet therapy according to the local standard; DAPT was discontinued in 85% of pts within 1 year. CHA2DS2-VASc and HAS-BLED scores were 4...
January 9, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29306469/value-of-dapt-score-to-predict-adverse-outcome-in-patients-with-atrial-fibrillation-undergoing-percutaneous-coronary-intervention-a-post-hoc-analysis-from-the-afcas-registry
#18
Wail Nammas, Tuomas Kiviniemi, Axel Schlitt, Andrea Rubboli, Josè Valencia, Gregory Y H Lip, Pasi P Karjalainen, Fausto Biancari, K E Juhani Airaksinen
BACKGROUND: The DAPT score identifies patients with expected benefit from extended dual antiplatelet therapy beyond 1year after percutaneous coronary intervention (PCI). In a post-hoc analysis from the AFCAS registry, we explored the value of DAPT score to predict outcome in patients with atrial fibrillation (AF) undergoing PCI. METHODS AND RESULTS: Outcome measures included major adverse cardiac/cerebrovascular events (MACCE) [all-cause death, myocardial infarction, repeat revascularization, stent thrombosis, or stroke/transient ischemic attack] and bleeding events...
February 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29237921/impact-of-proton-pump-inhibitors-on-the-pharmacodynamic-effect-and-clinical-outcomes-in-patients-receiving-dual-antiplatelet-therapy-after-percutaneous-coronary-intervention-a-propensity-score-analysis
#19
Pei Zhu, Zhan Gao, Xiao-Fang Tang, Jing-Jing Xu, Yin Zhang, Li-Jian Gao, Jue Chen, Shu-Bin Qiao, Yue-Jin Yang, Run-Lin Gao, Bo Xu, Jin-Qing Yuan
BACKGROUND: Prior studies have reported controversial conclusions regarding the risk of adverse cardiovascular events in patients using proton-pump inhibitors (PPIs) combined with clopidogrel therapy, causing much uncertainty in clinical practice. We sought to evaluate the safety of PPIs use among high-risk cardiovascular patients who underwent percutaneous coronary intervention (PCI) in a long-term follow-up study. METHODS: A total of 7868 consecutive patients who had undergone PCI and received dual antiplatelet therapy (DAPT) at a single center from January 2013 to December 2013 were enrolled...
December 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29167614/thirty-day-and-one-year-clinical-outcomes-of-bioresorbable-vascular-scaffold-implantation-a-single-center-experience
#20
Wei-Chieh Lee, Chiung-Jen Wu, Chien-Jen Chen, Cheng-Hsu Yang, Shu-Kai Hsueh, Hon-Kan Yip, Chi-Ling Hang, Chih-Yuan Fang, Hsiu-Yu Fang
Background: Available data on the use of the Bioresorbable vascular scaffold (BVS) (Abbott Vascular, Santa Clara, CA) in real-world patients is limited, particularly in Asian populations. The aim of this study was to assess clinical outcomes of patients treated with a BVS in real-world practice in Taiwan. Methods: This study focused on 156 patients with coronary artery disease and a total of 249 lesions who received BVS implantation from October 2012 to October 2015...
November 2017: Acta Cardiologica Sinica
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