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M Sokolova, N Tsvetaeva, G Sukhanova, S Vasiliev, A Misurin, M Sanatko, M Nareiko, V Rudakova, E Semenova, N Khoroshko
No abstract text is available yet for this article.
2012: Mediterranean Journal of Hematology and Infectious Diseases
V Tutaeva, A V Misurin, J J Michiels, J M Rozenberg, M A Sokolova, V L Ivanova, T I Kolosheinova, T E Manakova, A A Levina, E A Semenova, N D Khoroshko
Increased PRV-1 mRNA expression and the presence of Jak2(V617F) mutation in peripheral blood granulocytes are specific markers for chronic myeloproliferative disorders (MPD), which facilitate the differential diagnosis between polycythemia vera (PV) and secondary erythrocytosis (SE) and may be helpful for monitoring treatment efficacy in MPD patients. We evaluated the presence of the Jak2V617F mutation and increased PRV-1 mRNA expression along with previously established markers - erythropoietin (EPO) independent colony formation (EEC) and erythropoietin level for diagnosis of PV and assessment of treatment efficiency...
December 2007: Hematology (Amsterdam, Netherlands)
Sergiy Klymenko, Klaus Trott, Michael Atkinson, Karin Bink, Vladimir Bebeshko, Dimitry Bazyka, Iryna Dmytrenko, Iryna Abramenko, Nadia Bilous, Andrei Misurin, Horst Zitzelsberger, Michael Rosemann
Several studies suggested a causal link between AML1 gene rearrangements and both radiation-induced acute myeloid leukaemia (AML) and myelodysplastic syndromes (MDS). Fifty-three AML samples were analyzed for the presence of AML1 abnormalities using fluorescent in-situ hybridization (FISH) and reverse transcription polymerase chain reaction (RT-PCR). Of these patients, 24 had experienced radiation exposure due to the Chernobyl accident, and 29 were non-irradiated spontaneous AML cases and served as controls...
June 2005: Journal of Radiation Research
Sergiy V Klymenko, Karin Bink, Klaus R Trott, Vladimir G Bebeshko, Dimitry A Bazyka, Iryna V Dmytrenko, Iryna V Abramenko, Nadia I Bilous, Horst Zitzelsberger, Andrei V Misurin, Michael J Atkinson, Michael Rosemann
AIM: Although acute myelogenous leukemia (AML) arising after radiation exposure is considered to be secondary, little is known about the molecular mechanisms by which the radiation induces the leukemogenic phenotype. The aim of the study was to analyze whether the MLL translocations are as frequent in radiation-associated AML as in spontaneous AML cases. METHODS: Sixty one AML samples obtained at diagnosis were analyzed for the presence of MLL abnormalities using fluorescent in situ hybridization and/or reverse transcription polymerase chain reaction...
March 2005: Experimental Oncology
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