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head and neck tumours

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https://www.readbyqxmd.com/read/28218905/phosphorylation-mediated-activation-of-ldha-promotes-cancer-cell-invasion-and-tumour-metastasis
#1
L Jin, J Chun, C Pan, G N Alesi, D Li, K R Magliocca, Y Kang, Z G Chen, D M Shin, F R Khuri, J Fan, S Kang
Metastases remain the major cause of death from cancer. Recent molecular advances have highlighted the importance of metabolic alterations in cancer cells, including the Warburg effect that describes an increased glycolysis in cancer cells. However, how this altered metabolism contributes to tumour metastasis remains elusive. Here, we report that phosphorylation-induced activation of lactate dehydrogenase A (LDHA), an enzyme that catalyses the interconversion of pyruvate and lactate, promotes cancer cell invasion, anoikis resistance and tumour metastasis...
February 20, 2017: Oncogene
https://www.readbyqxmd.com/read/28209109/a-rare-case-of-giant-mesenteric-cystic-lymphangioma-of-the-small-bowel-in-an-adult-a-case-presentation-and-literature-review
#2
Z Mehmedovic, M Mehmedovic, M K Custovic, A Sadikovic, N Mekic
Background : Lymphangiomas are tumours that are often found in the head and neck in children and, rarely, in adults. Among all lymphangiomas in adults, the small bowel mesentery type accounts for less than 1%. We aim to present a rare case of small bowel symptomatic cystic lymphangioma in an adult patient, as well as its diagnosis and subsequent treatment. Patient : An adult female who was admitted to the University Clinical Center Tuzla for surgery presented with abdominal pain, tenderness and swelling of the abdomen...
September 2016: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/28208989/central-telangiectatic-osteosarcoma-of-the-mandible-in-a-paediatric-patient-a-rarity
#3
Divya Tomar, Manu Dhillon, Muhamad Nishad Thayath, Iram Zaidi, Shikha Singh
Osteosarcoma (OS) involving the head and neck region is rare and is a diagnostic challenge due to its aggressive nature and varied presentations. Although OS constitute 40% to 60% of all bone tumours, only 10% of these occur in the head and neck region, most commonly in the maxilla and mandible. OS of the jaw bone has a different pattern and behaviour when compared to OS at other anatomic location. It occurs in a more elderly population, less aggressive and usually spreads locally rather than distant metastases...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28208975/solid-cystic-hypoglossal-nerve-schwannoma-with-fluid-fluid-level-a-rare-case-report
#4
Kulamani Sahoo, Pramod Ramchand Shaha, Rahul Khetawat, Mohd Abbas Ilyas, Gaurav Rajendra Khairnar
Schwannomas (neurinoma, neurilemmoma) are benign slow-growing encapsulated tumours originating from well-differentiated myelin-producing Schwann cells or nerve fiber sheet cells at the glial-Schwann cell junction. Hypoglossal nerve schwannoma mostly develops in the intracranial and extra-cranial segment or in both intracranial and extra-cranial segment forming a dumbbell shape tumour. The peripheral hypoglossal schwannomas are very rare. We present a case of right hypoglossal nerve schwannoma in a 46-year-old female who presented with headache and neck pain since 2 weeks with deviation of tongue to right side since 1 week...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28203620/schwannoma-of-the-tongue-a-common-tumour-in-a-rare-location-a-case-report
#5
Ines Abreu, Diogo Roriz, Pedro Rodrigues, Ângela Moreira, Cristina Marques, Filipe Caseiro Alves
Schwannoma is a benign tumour that arises from Schwann cells of the peripheral nerve sheath, and is a common tumour of the head and neck. However, intraoral location is very uncommon (only 1% of all head and neck schwannomas). We report a rare case of lingual schwannoma in a 20-year-old male patient who presented with a small, slow-growing mass over the right lateral border of the tongue with 1 year of evolution and that became recently ulcerated. The patient underwent MRI examination and complete surgical excision...
2017: European Journal of Radiology Open
https://www.readbyqxmd.com/read/28198401/enrichment-of-circulating-head-and-neck-tumour-cells-using-spiral-microfluidic-technology
#6
Arutha Kulasinghe, Thao Huynh Phuoc Tran, Tony Blick, Ken O'Byrne, Erik W Thompson, Majid E Warkiani, Colleen Nelson, Liz Kenny, Chamindie Punyadeera
Whilst locoregional control of head and neck cancers (HNCs) has improved over the last four decades, long-term survival has remained largely unchanged. A possible reason for this is that the rate of distant metastasis has not changed. Such disseminated disease is reflected in measurable levels of cancer cells in the blood of HNC patients, referred to as circulating tumour cells (CTCs). Numerous marker-independent techniques have been developed for CTC isolation and detection. Recently, microfluidics-based platforms have come to the fore to avoid molecular bias...
February 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28194032/tumour-specific-pi3k-inhibition-via-nanoparticle-targeted-delivery-in-head-and-neck-squamous-cell-carcinoma
#7
Aviram Mizrachi, Yosi Shamay, Janki Shah, Samuel Brook, Joanne Soong, Vinagolu K Rajasekhar, John L Humm, John H Healey, Simon N Powell, José Baselga, Daniel A Heller, Adriana Haimovitz-Friedman, Maurizio Scaltriti
Alterations in PIK3CA, the gene encoding the p110α subunit of phosphatidylinositol 3-kinase (PI3Kα), are frequent in head and neck squamous cell carcinomas. Inhibitors of PI3Kα show promising activity in various cancer types, but their use is curtailed by dose-limiting side effects such as hyperglycaemia. In the present study, we explore the efficacy, specificity and safety of the targeted delivery of BYL719, a PI3Kα inhibitor currently in clinical development in solid tumours. By encapsulating BYL719 into P-selectin-targeted nanoparticles, we achieve specific accumulation of BYL719 in the tumour milieu...
February 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/28193302/outcomes-of-transoral-laser-microsurgical-management-of-t1b-stage-glottic-cancer
#8
J A Song, M H Rigby, J Trites, R D Hart, S M Taylor
OBJECTIVE: This study aimed to evaluate the oncological and voice outcomes of transoral laser microsurgery for tumour stage T1b stage glottic cancer patients. METHODS: A prospective cohort study in a tertiary care head and neck cancer centre included tumour-node-metastasis stage T1bN0M0 glottic cancer patients scheduled to undergo transoral laser microsurgery from January 2002 until June 2014. Kaplan-Meier five-year analyses of local control, overall survival, disease-specific survival and laryngeal preservation were performed...
February 14, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28186838/biological-dose-escalated-definitive-radiation-therapy-in-head-and-neck-cancer
#9
Brigida da Costa Ferreira, Pedro Sá-Couto, Leila Khouri, Maria do Carmo Lopes
OBJECTIVE: To compare treatment outcome of patients with head and neck (HN) tumours treated with definitive Radiation Therapy (RT) that, mainly due to differences in the fractionation scheme used with simultaneous integrated boost techniques, resulted in a different biological dose. METHODS: 181 HN cancer patients, prescribed to about 70.2 Gy in the primary tumour, were included in this study. Population cohort was divided into Group <70 and Group ≥70 when the mean dose converted to a 2 Gy fractionation in the primary tumour was less or higher than 70...
February 10, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28179315/validation-of-human-papillomavirus-as-a-favourable-prognostic-marker-and-analysis-of-cd8-tumour-infiltrating-lymphocytes-and-other-biomarkers-in-cancer-of-unknown-primary-in-the-head-and-neck-region
#10
Lars Sivars, David Landin, Nathalie Grün, Andrea Vlastos, Linda Marklund, Sushma Nordemar, Torbjörn Ramqvist, Eva Munck-Wikland, Anders Näsman, Tina Dalianis
BACKGROUND: Human papillomavirus (HPV) is a favourable prognostic factor in oropharyngeal cancer. Moreover, we and others reported that HPV-positive cancer of unknown primary in the head and neck region (HNCUP) has better outcome than HPV-negative HNCUP. However, not all studies concord. Here, our previous finding was investigated in a new cohort and additional biomarkers were analyzed. MATERIALS AND METHODS: A total of 19 HNCUPs diagnosed 2008-2013 were analyzed for HPV DNA by polymerase chain reaction assay (PCR) and p16 by immunohistochemistry (IHC)...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28174141/checkpoint-inhibition-for-advanced-mucosal-melanoma
#11
Julia Thierauf, Johannes A Veit, Jochen Hess, Nicolai Treiber, Catharina Lisson, Stephanie E Weissinger, Martin Bommer, Thomas K Hoffmann
BACKGROUND: Whereas anti-PD-1 therapy has demonstrated a significant and durable response against advanced cutaneous melanoma, conventional chemotherapies have shown only minor benefit against advanced mucosal melanoma. OBJECTIVES: To investigate the efficacy of anti-PD-1 therapy in a small cohort of patients with mucosal melanoma of the head and neck. MATERIAL & METHODS: We analysed five patients with mucosal melanoma of the head and neck who received nivolumab or pembrolizumab, at an advanced stage...
February 3, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28167693/primary-gastric-plasmacytoma-a-rare-entity
#12
Rui Caetano Oliveira, Pedro Amaro, Maria José Julião, Maria Augusta Cipriano
Extramedullary plasmacytomas (EP) are tumours composed by a monoclonal population of plasma cells that arise in extraosseus tissues, comprising <5% of all plasma cell neoplasms. Usually, EP arise in the head and neck region, and the stomach is the second most common location-gastric plasmacytoma (GP). Clinical and radiological manifestations are unspecific and may mimic other tumours like gastric adenocarcinomas, gastric stromal tumours and lymphomas, mainly marginal cell lymphoma (MALT lymphoma) and usually definitive diagnosis is provided by pathological evaluation...
February 6, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28151534/targeted-nanoparticles-for-tumour-radiotherapy-enhancement-the-long-dawn-of-a-golden-era
#13
Elisabetta Gargioni, Florian Schulz, Annette Raabe, Susanne Burdak-Rothkamm, Thorsten Rieckmann, Kai Rothkamm
Despite considerable progress in (I) our understanding of the aetiopathology of head and neck cancer and (II) the precise delivery of radiotherapy, long-term survival rates for many patients with head and neck cancer remain disappointingly low. Over the past years, gold nanoparticles (NP) have emerged as promising radiation dose enhancers. In a recent study published in Nanoscale, Popovtzer et al. have used gold NP coated with an antibody against the epidermal growth factor receptor (EGFR) in an attempt to enhance radiation-induced tumour cell killing in a head and neck cancer xenograft model...
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28140483/current-update-on-the-diagnosis-and-management-of-head-and-neck-soft-tissue-sarcomas
#14
REVIEW
Ben Tudor-Green, Ricardo Gomez, Peter A Brennan
Head and neck soft tissue sarcomas are a group of rare heterogeneous tumours arising from embryonic mesoderm. They comprise less than 1% of all head and neck malignancies and 5-15% of all sarcomas with most head and neck sarcomas arising from soft tissues. Although rare, they are associated with both high recurrence and mortality rates. We review the current management of head and neck soft tissue sarcomas. This article is protected by copyright. All rights reserved.
January 31, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28131548/an-orally-bioavailable-chk1-inhibitor-cct244747-sensitizes-bladder-and-head-and-neck-cancer-cell-lines-to-radiation
#15
Radhika Patel, Holly E Barker, Joan Kyula, Martin McLaughlin, Magnus T Dillon, Ulrike Schick, Hind Hafsi, Alan Thompson, Vincent Khoo, Kevin Harrington, Shane Zaidi
PURPOSE: Chk1 inhibition increases cell sensitivity to both chemotherapy and radiotherapy in several tumour types and is, therefore, a promising anti-cancer approach. Although several Chk1 inhibitors have been developed, their clinical progress has been hampered by low bioavailability and off-target toxicities. MATERIALS AND METHODS: We characterized the radiosensitizing activity of CCT244747, the first orally bioavailable Chk1 inhibitor. We used a panel of bladder and head and neck cancer cell lines and monitored the effect of combining CCT244747 with radiation both in in vitro and in vivo models...
January 25, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28129434/development-of-an-in-silico-stochastic-4d-model-of-tumour-growth-with-angiogenesis
#16
Jake C Forster, Michael J J Douglass, Wendy M Harriss-Phillips, Eva Bezak
PURPOSE: A stochastic computer model of tumour growth with spatial and temporal components that includes tumour angiogenesis was developed. In the current work it was used to simulate head and neck tumour growth. The model also provides the foundation for a 4D cellular radiotherapy simulation tool. METHODS: The model, developed in Matlab, contains cell positions randomised in 3D space without overlap. Blood vessels are represented by strings of blood vessel units which branch outwards to achieve the desired tumour relative vascular volume...
January 27, 2017: Medical Physics
https://www.readbyqxmd.com/read/28126329/head-and-neck-target-delineation-using-a-novel-pet-automatic-segmentation-algorithm
#17
B Berthon, M Evans, C Marshall, N Palaniappan, N Cole, V Jayaprakasam, T Rackley, E Spezi
PURPOSE: To evaluate the feasibility and impact of using a novel advanced PET auto-segmentation method in Head and Neck (H&N) radiotherapy treatment (RT) planning. METHODS: ATLAAS, Automatic decision Tree-based Learning Algorithm for Advanced Segmentation, previously developed and validated on pre-clinical data, was applied to (18)F-FDG-PET/CT scans of 20 H&N patients undergoing Intensity Modulated Radiation Therapy. Primary Gross Tumour Volumes (GTVs) manually delineated on CT/MRI scans (GTVpCT/MRI), together with ATLAAS-generated contours (GTVpATLAAS) were used to derive the RT planning GTV (GTVpfinal)...
January 23, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28122884/risk-of-cerebrovascular-events-in-178-962-5-year-survivors-of-cancer-diagnosed-aged-15-39-years-the-teenage-and-young-adults-cancer-survivors-study-tyacss
#18
Chloe J Bright, Michael Hawkins, Joyeeta Guha, Katherine E Henson, David Winter, Julie S Kelly, Richard G Feltbower, Marlous Hall, David J Cutter, Angela B Edgar, Clare Frobisher, Raoul C Reulen
BACKGROUND: -Survivors of teenage and young adult (TYA) cancer are at risk of cerebrovascular events, but the magnitude of and extent to which this risk varies by cancer type, decade of diagnosis, age at diagnosis and attained age remains uncertain. This is the largest ever cohort study to evaluate the risks of hospitalisation for a cerebrovascular event among long-term survivors of TYA cancer. METHODS: -The population-based Teenage and Young Adult Cancer Survivor Study (N=178,962) was linked to Hospital Episode Statistics data for England to investigate the risks of hospitalisation for a cerebrovascular event among 5-year survivors of cancer diagnosed when aged 15-39 years...
January 25, 2017: Circulation
https://www.readbyqxmd.com/read/28116485/somatic-leiomyosarcoma-of-the-soft-tissues-a-single-institutional-analysis-of-factors-predictive-of-survival-in-164-patients
#19
Kamran Harati, Adrien Daigeler, Kim Lange, Hiltrud Niggemann, Ingo Stricker, Hans-Ulrich Steinau, Marcus Lehnhardt, Ole Goertz
BACKGROUND: Somatic leiomyosarcoma (LMS) is an aggressive soft tissue sarcoma entity with a high metastatic potential. The purpose of this study was to identify prognostic indicators of survival in patients with somatic LMS of the soft tissues. METHODS: We retrospectively assessed the relationship between local recurrence-free survival (LRFS), disease-specific survival (DSS), overall survival (OS) and potential prognostic factors in 164 patients who were suitable for surgical treatment in curative intent...
January 23, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28112249/decreased-expression-of-pseudogene-ptenp1-promotes-malignant-behaviours-and-is-associated-with-the-poor-survival-of-patients-with-hnscc
#20
Jiannan Liu, Yue Xing, Liqun Xu, Wantao Chen, Wei Cao, Chenping Zhang
PTENP1, a pseudogene of PTEN, was previously reported to be a tumour suppressor in some cancer types. However, there was no evidence for the biological function and expression of PTENP1 in head and neck squamous cell carcinoma (HNSCC). Here, we evaluated the function and clinical implications of PTENP1 in HNSCC. Using RT-PCR and quantitative real-time PCR (qRT-PCR), we found that the level of PTENP1 was reduced in HNSCC specimens compared with adjacent tissues. A decrease in the PTENP1 copy number, but not in the PTEN copy number, was frequently observed in tumour cell lines (4 of 5 cell lines) by genomic real-time PCR...
January 23, 2017: Scientific Reports
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