keyword
MENU ▼
Read by QxMD icon Read
search

head and neck tumours

keyword
https://www.readbyqxmd.com/read/29676381/ectopic-hidradenoma-papilliferum-of-eyelid-a-rare-entity-with-diagnostic-challenge
#1
Prakriti Shukla, Anil K Malaviya
Hidradenoma papilliferum is a rare cutaneous adnexal tumour of middle aged females arising mainly in the apocrine sweat glands of perianal and genital region. Ectopic forms of this entity have been described with majority of them occurring on the head and neck region. We report a case of 16 years young male who presented with two small, well circumscribed, greyish-brown, firm, nodules on his left upper and lower eyelid. A clinical impression of basal cell carcinoma was assumed but on histopathological examination it was diagnosed as hidradenoma papilliferum of eyelid...
April 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29671218/neuroimaging-of-meckel-s-cave-in-normal-and-disease-conditions
#2
REVIEW
Ajay Malhotra, Long Tu, Vivek B Kalra, Xiao Wu, Ali Mian, Rajiv Mangla, Elias Michaelides, Pina Sanelli, Dheeraj Gandhi
Meckel's cave is a dural recess in the posteromedial portion of the middle cranial fossa that acts as a conduit for the trigeminal nerve between the prepontine cistern and the cavernous sinus, and houses the Gasserian ganglion and proximal rootlets of the trigeminal nerve. It serves as a major pathway in perineural spread of pathologies such as head and neck neoplasms, automatically upstaging tumours, and is a key structure to assess in cases of trigeminal neuralgia. The purpose of this pictorial review is threefold: (1) to review the normal anatomy of Meckel's cave; (2) to describe imaging findings that identify disease involving Meckel's cave; (3) to present case examples of trigeminal and non-trigeminal processes affecting Meckel's cave...
April 18, 2018: Insights Into Imaging
https://www.readbyqxmd.com/read/29671207/correction-to-solitary-fibrous-tumours-in-the-extracranial-head-and-neck-region-correlation-of-ct-and-mr-features-with-pathologic-findings
#3
Yu Liu, KaiCheng Li, Huimin Shi, XiaoFeng Tao
Solitary fibrous tumours (SFTs) are rare, mesenchymal neoplasms. The purpose of this study was to analyse the radiological and clinicopathological features of SFTs in the extracranial head and neck region.
April 18, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29671054/survivin-expression-in-head-and-neck-squamous-cell-carcinomas-is-frequent-and-correlates-with-clinical-parameters-and-treatment-outcomes
#4
Adrian Münscher, Sebastian Prochnow, Amit Gulati, Guido Sauter, Balazs Lörincz, Marco Blessmann, Henning Hanken, Arne Böttcher, Till Sebastian Clauditz
OBJECTIVES: Strong expression of survivin is associated with worse survival in many different tumours, and in cell culture, a correlation between radiation resistance and survivin expression can be seen. The potential of survivin expression as a prognostic/predictive marker or therapeutic target has not been examined in head and neck squamous cell carcinomas (HNSCC) yet. MATERIAL AND METHODS: Retrospective study of 452 tissue samples and clinical data from patients with squamous cell carcinomas of the larynx/hypopharynx (LSCC), oral cavity (OSCC) and oropharynx (OPSCC) treated in the University Medical Centre Hamburg-Eppendorf between 2002 and 2006...
April 18, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29669769/nasal-septal-schwannoma-a-rare-sinonasal-tumour-with-certain-peculiarities
#5
K Devaraja, Dipak Ranjan Nayak, Balakrishnan Ramaswamy, Prerit Rao
Sinonasal schwannomas constitute 4% of head and neck nerve sheath tumours; however, schwannomas involving the nasal septum are quite rare. We present a 57-year-old male patient with nasal septal schwannoma who was managed successfully by endoscopic excision. 32 cases of septal schwannoma have been reported so far in the literature. This report discusses certain peculiar features exhibited by schwannomas of the nasal septum. Septal schwannoma does not show any age, sex or side predilection. However, they tend to involve posterior part of the septum and presumed to arise from the nasopalatine branch of the trigeminal nerve...
April 18, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29668302/clinical-factors-impacting-on-late-dysphagia-following-radiotherapy-in-patients-with-head-and-neck-cancer
#6
Sarah Deschuymer, Daan Nevens, Fréderic Duprez, Annouschka Laenen, Eddy Dejaeger, Wilfried De Neve, Ann Goeleven, Sandra Nuyts
OBJECTIVE: Patient and treatment characteristics of patients with head and neck cancer (HNSCC) were correlated with dysphagia scored on swallowing-videofluoroscopy (VFS) and with patient and physician scored dysphagia. METHODS: Sixty-three HNSCC patients treated with radiotherapy (RT) were evaluated at baseline, 6 and 12 months post-RT. VFS was scored with Penetration Aspiration Scale (PAS) and Swallowing Performance Scale (SPS). Physician and patient scored dysphagia were prospectively recorded according to CTCAE scoring system, RTOG/EORTC scoring system and EORTC-QLQ H&N35 questionnaire...
April 18, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29667751/suz12-is-a-novel-putative-oncogene-promoting-tumorigenesis-in-head-and-neck-squamous-cell-carcinoma
#7
Yaping Wu, Huijun Hu, Wei Zhang, Zhongwu Li, Pengfei Diao, Dongmiao Wang, Wei Zhang, Yanling Wang, Jianrong Yang, Jie Cheng
The suppressor of zest 12 (SUZ12), one of the core polycomb repressive complex 2 (PRC2) components, has increasingly appreciated as a key mediator during human tumorigenesis. However, its expression pattern and oncogenic roles in head and neck squamous cell carcinoma (HNSCC) remain largely unexplored yet. Here, we sought to determine its expression pattern, clinicopathological significance and biological roles in HNSCC. Through data mining and interrogation from multiple publicly available databases, our bioinformatics analyses revealed that SUZ12 mRNA was significantly overexpressed in multiple HNSCC patient cohorts...
April 18, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29667275/clinicopathological-significance-of-mir-26-mir-107-mir-125b-and-mir-203-in-head-and-neck-carcinomas
#8
Wilfredo Alejandro González-Arriagada, Pablo Olivero, Belén Rodríguez, Carlo Lozano-Burgos, Carine Ervolino de Oliveira, Ricardo D Coletta
OBJECTIVES: MicroRNAs play a role in the development and progression of head and neck squamous cell carcinomas (HNSCC). Our aim was to study the expression of miR-26, miR-107, miR-125b and miR-203 in primary HNSCC with and without lymph node metastasis and their clinicopathological significance. MATERIALS AND METHODS: The expression of microRNAs in primary HNSCC with lymph node metastasis (n=16), and their matched lymph node, as well as primary tumours without metastasis (n=16), were determined by quantitative RT-PCR, and analysed with clinicopathological features and survival...
April 18, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29652178/multi-modal-imaging-for-dose-planning-and-its-benefits-the-paradigm-of-head-and-neck-tumours
#9
V Grégoire
The ultimate goal of any radiotherapy is to eradicate the disease without inflicting damage on the normal tissues surrounding the tumours, which could be responsible for late treatment morbidity. To achieve this objective, the first step is to precisely select and delineate the target volumes to which a given dose will be prescribed. This step requires the use of multi-modal images from clinical examination to anatomical and molecular images. Imaging examination will be used not only to delineate the boundaries of the tumour volume, but also to assess tumour heterogeneity and, possibly, to guide a heterogeneous dose prescription (i...
January 1, 2018: Annals of the ICRP
https://www.readbyqxmd.com/read/29627149/combined-bilobed-trapezius-myocutaneous-and-scapula-osteomyocutaneous-flaps-for-the-restoration-of-through-and-through-defects-of-the-mandible-following-salvage-surgery-for-recurrent-head-and-neck-tumours
#10
W-L Chen, Z-Q Huang, B Zhou, Y Wang, R Chen
This study was performed to evaluate the outcomes of combined bilobed trapezius myocutaneous and scapula osteomyocutaneous flaps for the restoration of through-and-through defects of the mandible. The subjects were six patients with recurrent malignant tumours who underwent salvage surgeries and reconstruction with combined flaps based on the transverse cervical vessels (TCVs). All patients had combined bone (four type H, one type LCL, and one type C) and extensive soft tissue defects (through-and-through defects) following salvage surgery...
April 4, 2018: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29626940/pet-mri-in-infection-and-inflammation
#11
REVIEW
Martina Sollini, Raffaella Berchiolli, Margarita Kirienko, Alexia Rossi, A W J M Glaudemans, Riemer Slart, Paola Anna Erba
Hybrid positron emission tomography/magnetic resonance imaging (PET/MR) systems are now more and more available for clinical use. PET/MR combines the unique features of MR including excellent soft tissue contrast, diffusion-weighted imaging, dynamic contrast-enhanced imaging, fMRI and other specialized sequences as well as MR spectroscopy with the quantitative physiologic information that is provided by PET. Most of the evidence of the potential clinical utility of PET/MRI is available for neuroimaging. Other areas, where PET/MR can play a larger role include head and neck, upper abdominal, and pelvic tumours...
May 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29624473/preferential-allelic-deletion-of-rbsp3-limd1-and-cdc25a-in-head-and-neck-squamous-cell-carcinoma-implication-in-cancer-screening-and-early-detection
#12
Shreya Sarkar, Chinmay Kumar Panda
Head and neck squamous cell carcinoma is one of the leading cancers in terms of incidence and mortality. However, no reliable marker till date accurately predicts its progression when altered in healthy tissues. The study aims to identify alleles of microsatellites adjacent to important cell cycle regulatory, tumor suppressor genes altered in early head and neck lesions, viz. RBSP3, LIMD1 and CDC25A, which undergo frequent deletion and can be used for population screening and early detection. DNA for tumors and normal tissues was isolated from 143 patients in different stages of head and neck squamous cell carcinoma...
April 6, 2018: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/29611749/-the-possible-role-of-the-timing-of-the-first-oncological-treatment-on-the-survival-rate-of-cancer-diseases-a-literature-overview
#13
László Mangel, Tamás Tornóczky, Antal Zemplényi, Imre Boncz
The aim of this study was to survey the effects of the waiting time for the first oncology treatment in cancer diseases. By the analysis of 67 retrospective studies and reviews the numerical effects of treatment initiation time on survival were assessed. The "time factor" has a leading role on cancer types with aggressive biological behaviour, like breast cancer in younger age, testicular cancers, or head and neck tumours. However, a few days and reasonable delay to the first oncology intervention has no negative impact in numerous cancer diseases...
April 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29610456/potential-of-quantitative-sept9-and-shox2-methylation-in-plasmatic-circulating-cell-free-dna-as-auxiliary-staging-parameter-in-colorectal-cancer-a-prospective-observational-cohort-study
#14
Julia Bergheim, Alexander Semaan, Heidrun Gevensleben, Susanne Groening, Andreas Knoblich, Jörn Dietrich, Julia Weber, Jörg C Kalff, Friedrich Bootz, Glen Kristiansen, Dimo Dietrich
BACKGROUND: Septin 9 (SEPT9) and short stature homeobox 2 (SHOX2) methylation in circulating cell-free DNA (ccfDNA) are powerful biomarkers for colorectal cancer (CRC) screening, as well as head and neck squamous cell carcinoma staging and monitoring. In the present study, we investigated SEPT9 and SHOX2 ccfDNA methylation as auxiliary pre and post-therapeutic staging parameters in CRC patients. METHODS: ccfDNA methylation was quantified in 184 prospectively enrolled patients prior to and 3-10 days after surgery, and biomarker levels were associated with clinico-pathological parameters...
April 3, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29607722/ethmoidal-metastasis-as-a-first-presentation-of-breast-cancer-a-case-report
#15
A Maity, E Maughan, S Vasani, G Alusi
Distant metastasis in advanced breast cancer is not uncommon; however, spread to the paranasal sinuses is extremely rare. We present a case of a woman who presented to our ophthalmology colleagues with worsening unilateral proptosis secondary to a tumour mass within her ethmoid sinuses. Biopsy of the ethmoid tumour showed adenocarcinoma of unknown origin. Whole-body positron emission computed tomography demonstrated a breast primary lesion. The patient was treated with palliative chemotherapy, and the patient remains well at this point...
April 1, 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29606027/effects-of-cisplatin-5-fluorouracil-combination-therapy-on-oxidative-stress-dna-damage-mitochondrial-apoptosis-and-death-receptor-signalling-in-retinal-pigment-epithelium-cells
#16
Hande Güçlü, Zeynep Banu Doganlar, Vuslat Pelitli Gürlü, Altan Özal, Ayten Dogan, Meryem Aysenur Turhan, Oguzhan Doganlar
Combination therapies of cisplatin with 5-FU (PF) are an effective solution and have been widely used for the treatment of various categories of cancer. including anal, gastrointestinal and oral cancer, as well as head and neck tumours. The effects of combined PF treatment on vital intracellular signalling pathways in nontargeted cells remain unclear. The aim of this study is to explain the possible mechanisms by which combined PF treatment results in retinal toxicity and to investigate the effects of PF on important vital signalling pathways in ARPE 19 retinal pigmented epithelial cells...
April 2, 2018: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/29603728/distinct-profiles-of-tert-promoter-mutations-and-telomerase-expression-in-head-and-neck-cancer-and-cervical-carcinoma
#17
Clorinda Annunziata, Francesca Pezzuto, Stefano Greggi, Franco Ionna, Simona Losito, Gerardo Botti, Luigi Buonaguro, Franco M Buonaguro, Maria Lina Tornesello
Two recurrent mutations (-124 G>A and -146 G>A) in the core promoter region of the human telomerase reverse transcriptase (TERT) gene create consensus binding sites for ETS transcription factors and cause increased TERT expression in several tumour types. We analyzed TERT promoter mutations and TERT mRNA levels in head and neck cancer, cervical carcinoma and cervical intraepithelial neoplasia (CIN) as well as in C-4I, CaSki, HeLa and SiHa cervical cell lines. Nucleotide sequence analysis of TERT promoter region showed that 33...
March 31, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29594214/sdf-1-cxcr4-expression-in-head-and-neck-cancer-and-outcome-after-postoperative-radiochemotherapy
#18
Chiara De-Colle, David Mönnich, Stefan Welz, Simon Boeke, Bence Sipos, Falko Fend, Paul-Stefan Mauz, Inge Tinhofer, Volker Budach, Jehad Abu Jawad, Martin Stuschke, Panagiotis Balermpas, Claus Rödel, Anca-Ligia Grosu, Amir Abdollahi, Jürgen Debus, Christine Bayer, Claus Belka, Steffi Pigorsch, Stephanie E Combs, Fabian Lohaus, Annett Linge, Mechthild Krause, Michael Baumann, Daniel Zips, Apostolos Menegakis
Introduction: Outcome after postoperative radiochemotherapy (RT-CT) for patients with advanced head and neck squamous cell carcinomas (HNSCC) remains unsatisfactory, especially among those with HPV negative tumours. Therefore, new biomarkers are needed to further define subgroups for individualised therapeutic approaches. Preclinical and first clinical observations showed that the chemokine receptor CXCR4 and its ligand SDF-1 (CXCL12) play an important role in tumour cell proliferation, survival, cancer progression, metastasis and treatment resistance...
August 2017: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29590180/pre-treatment-tumour-perfusion-parameters-and-initial-recist-response-do-not-predict-long-term-survival-outcomes-for-patients-with-head-and-neck-squamous-cell-carcinoma-treated-with-induction-chemotherapy
#19
Natalie M Lowe, Lucy E Kershaw, Jonathan M Bernstein, Stephanie B Withey, Kathleen Mais, Jarrod J Homer, Nicholas J Slevin, Suzanne C Bonington, Bernadette M Carrington, Catharine M West
OBJECTIVES: Previously, we showed that pre-treatment tumour plasma perfusion (Fp) predicts RECIST response to induction chemotherapy (ICT) in locoregionally advanced head and neck squamous cell carcinoma (HNSCC). The aim here was to determine whether the pre-treatment tumour Fp estimate, changes in tumour Fp or RECIST response post 2 cycles of ICT were prognostic for long-term survival outcomes. METHODS: A prospective study enrolled patients with high stage HNSCC treated with docetaxel (T), cisplatin (P) and 5-fluorouracil (F) (ICT) followed by synchronous cisplatin and intensity modulated radiotherapy...
2018: PloS One
https://www.readbyqxmd.com/read/29580683/mandibular-reconstruction-with-free-fibula-flaps-in-the-elderly-a-retrospective-evaluation
#20
Y Sugiura, S Sarukawa, J Hayasaka, H Kamochi, T Noguchi, Y Mori
The purpose of this study was to evaluate surgical outcomes in elderly patients who had undergone free fibula flap transfer for malignant head and neck tumours. A retrospective chart review was performed to identify patients who had undergone free fibula flap transfer for mandibular reconstruction after malignant tumour resection at Jichi Medical University Hospital between May 2009 and April 2015. Enrolled patients were divided into an elderly group (≥80years old) and a younger group (<80years old). Seventeen patients met the inclusion criteria and were included in the elderly group...
March 23, 2018: International Journal of Oral and Maxillofacial Surgery
keyword
keyword
96849
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"