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https://www.readbyqxmd.com/read/28087965/hypopharyngeal-cancer-masquerading-as-a-thyroid-mass
#1
P S Heng, M Irfan
Hypopharyngeal cancer (HPC) is generally a rare head and neck malignancy. There are differing clinical presentations depending on the subsite location of primary tumour. Advanced HPC will have neck node metastasis particularly upper jugulodigastric nodes. We report a patient with postcricoid tumour who presented with anterior huge neck swelling mimic thyroid mass. The patient first presented to the General Surgical Unit for management of presumed thyroid lesion. She was diagnosed post-cricoid squamous cell carcinoma when further assessed by otorhinolaryngologist...
December 2016: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/28061890/hpv-dna-in-saliva-from-patients-with-scc-of-the-head-and-neck-is-specific-for-p16-positive-oropharyngeal-tumours
#2
Jason K Wasserman, Ryan Rourke, Bibianna Purgina, Lisa Caulley, Jim Dimitroulakis, Martin Corsten, Stephanie Johnson-Obaseki
BACKGROUND: Human papillomavirus (HPV) is an important cause of head and neck squamous cell carcinoma (HNSCC), especially in young people. These tumours overexpress p16 and respond well to treatment. The rapid detection of HPV in patients with HNSCC may expedite treatment when p16 status is not immediately available. METHODS: Saliva-based DNA collection kits and nested polymerase chain reaction (PCR) were used to determine the HPV status of 62 individuals with biopsy-proven HNSCC...
January 6, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28055245/the-role-of-changes-in-maximum-standardized-uptake-value-of-fdg-pet-ct-for-post-treatment-surveillance-in-patients-with-head-and-neck-squamous-cell-carcinoma-treated-with-chemoradiotherapy-preliminary-findings
#3
Munetaka Matoba, Hiroyuki Tuji, Yuzo Shimode, Tamaki Kondo, Kiyotaka Oota, Hisao Tonami
OBJECTIVE: No clear consensus exists regarding the optimal interval and frequency of follow-up PET-CT in head and neck squamous cell carcinoma (HNSCC) patients treated with chemoradiotherapy (CRT). Here we sought to clarify whether the changes in the maximum standardized uptake value (ΔSUVmax) may be a valid parameter to help decision-making for surveillance management after CRT. METHODS: Forty patients underwent PET-CT at pretreatment and 3 months after CRT. Patients were followed by sequential PET-CT for 2 years after CRT...
January 5, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28050651/primary-transoral-robotic-surgery-with-concurrent-neck-dissection-for-early-stage-oropharyngeal-squamous-cell-carcinoma-implemented-at-a-danish-head-and-neck-cancer-center-a-phase-ii-trial-on-feasibility-and-tumour-margin-status
#4
Niclas Rubek, Hani Ibrahim Channir, Birgitte Wittenborg Charabi, Christel Bræmer Lajer, Katalin Kiss, Hans Ulrik Nielsen, Jens Bentzen, Jeppe Friborg, Christian von Buchwald
There is an increasing incidence of oropharyngeal squamous cell carcinoma (OPSCC) in the western world due to human papillomavirus (HPV). According to the Danish Head and Neck Cancer Group guidelines, the current recommended treatment of patients with OPSCC in Denmark is primary radiation therapy (RT) with or without concomitant chemotherapy. This is the first study in Scandinavia from a head and neck cancer centre that aims to demonstrate the feasibility of performing primary transoral robotic surgery (TORS) and concurrent neck dissection for patients with early stage OPSCC...
January 3, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28029105/cathepsin-b-degradable-nir-responsive-nanoparticulate-platform-for-target-specific-cancer-therapy
#5
Sam P Tarassoli, Alejandra Martinez de Pinillos Bayona, Hayley Pye, C Alexander Mosse, John F Callan, Alexander MacRobert, Anthony P McHale, Nikolitsa Nomikou
Stimuli-responsive anticancer formulations can promote drug release and activation within the target tumour, facilitate cellular uptake, as well as improve the therapeutic efficacy of drugs and reduce off-target effects. In the present work, indocyanine green (ICG)-containing polyglutamate (PGA) nanoparticles were developed and characterized. Digestion of nanoparticles with cathepsin B, a matrix metalloproteinase overexpressed in the microenvironment of advanced tumours, decreased particle size and increased ICG cellular uptake...
February 3, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28028856/british-association-of-dermatologists-national-audit-on-nonmelanoma-skin-cancer-excision-2014
#6
D J Keith, D A R de Berker, A P Bray, S T Cheung, A Brain, M F Mohd Mustapa
BACKGROUND: Diagnosis and management of nonmelanoma skin cancer (NMSC) represents a large part of the dermatology workload, and complete excision is a required surgical standard for treatment. AIM: To conduct an audit of the surgical practice for the treatment of NMSC by dermatologists in the UK. METHODS: Data on 10 consecutive nonmicrographic excisions of nonmelanoma skin cancer by UK dermatologists. Data collected included site, preoperative diagnosis, histological diagnosis, proximity to previous scars, and histological deep and peripheral margins...
January 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28028129/long-term-outcomes-after-carbon-ion-radiotherapy-for-oral-mucosal-malignant-melanoma
#7
Kensuke Naganawa, Masashi Koto, Ryo Takagi, Azusa Hasegawa, Hiroaki Ikawa, Kazuo Shimozato, Tadashi Kamada, Yoshitaka Okamoto
Oral mucosal malignant melanoma (OMM) is extremely rare and has a poor prognosis. Owing to its rarity, it has not yet been possible to establish an optimal treatment modality. The objective of this study was to evaluate the long-term efficacy of carbon-ion radiotherapy (C-ion RT) for OMM. Between 1997 and 2013, 19 patients with OMM were treated with C-ion RT alone. Patient ages ranged from 44 to 84 years (median, 69 years). Nine men and 10 women were included. OMMs were restaged in accordance with the seventh edition of the tumour/node/metastasis (TNM) Staging System of the International Union Against Cancer...
December 26, 2016: Journal of Radiation Research
https://www.readbyqxmd.com/read/28024728/laryngeal-tumours-and-radiotherapy-dose-to-the-cricopharyngeus-are-predictive-of-death-from-aspiration-pneumonia
#8
Jolyne O'Hare, Julia Maclean, Michal Szczesniak, Rashmi Gupta, Peter Wu, Harry Quon, Ian Cook, Peter Graham
OBJECTIVES: Aspiration pneumonia is an under-reported treatment sequelae following radiotherapy for head and neck cancer (HNC) patients. This study aims to investigate its incidence and risk factors in this population. MATERIALS AND METHODS: A retrospective review of all HNC patients that had received radiotherapy or chemo radiotherapy with radical intent at a single institution was undertaken (n=206). Dose delivered to the pharyngeal constrictors, base of tongue and cricopharyngeus was calculated and compared between those patients who had died from aspiration pneumonia and those who are alive or had died from other causes...
January 2017: Oral Oncology
https://www.readbyqxmd.com/read/28012793/pet-imaging-of-zirconium-89-labelled-cetuximab-a-phase-i-trial-in-patients-with-head-and-neck-and-lung-cancer
#9
Judith van Loon, Aniek J G Even, Hugo J W L Aerts, Michel Öllers, Frank Hoebers, Wouter van Elmpt, Ludwig Dubois, Anne-Marie C Dingemans, Roy I Lalisang, Pascal Kempers, Boudewijn Brans, Véronique Winnepenninckx, Ernst-Jan Speel, Eric Thunnissen, Kim M Smits, Ronald Boellaard, Danielle J Vugts, Dirk De Ruysscher, Philippe Lambin
BACKGROUND AND PURPOSE: PET imaging of cetuximab uptake may help selecting cancer patients with the highest chance of benefit. The aim of this phase I trial was to determine the safety of the tracer (89)Zr-cetuximab and to assess tumour uptake. METHODS: Two dose schedules were used; two consecutive doses of 60MBq (89)Zr-cetuximab or a single dose of 120MBq, both preceded by 400mg/m(2) of unlabelled cetuximab. Toxicity (CTCAE 3.0) was scored twice weekly. PET-CT scans were acquired on days 4, 5 and 6 (step 1) or 5, 6, 7 (step 2)...
December 21, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28008773/radiotherapy-response-evaluation-using-fdg-pet-ct-established-and-emerging-applications
#10
Helen Cliffe, Chirag Patel, Robin Prestwich, Andrew Scarsbrook
Radiation therapy is a common component of curative cancer treatment. However, there is a significant incidence of treatment failure. In these cases salvage surgical options are sometimes appropriate. Accurate assessment of response and early recognition of treatment success or failure is therefore critical to guide treatment decisions and impacts on survival and the morbidity of treatment. Traditionally, treatment response has depended upon anatomical measurement of disease. However, this may not correlate well with the presence of disease, especially after radiotherapy...
December 23, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/28005601/trends-in-net-survival-from-head-and-neck-cancer-in-six-european-latin-countries-results-from-the-sudcan-population-based-study
#11
Anne-Valérie Guizard, Zoé Uhry, Dominique de Raucourt, Guido Mazzoleni, Maria-José Sánchez, Karine Ligier
The aim of the SUDCAN collaborative study was to compare the trends in 1- and 5-year net survival and the trends in the dynamics of the excess mortality rates in head and neck cancers between six European Latin countries (Belgium, France, Italy, Portugal, Spain and Switzerland). The data were extracted from the EUROCARE-5 database. First, the net survival was studied over the 2000-2004 period using the Pohar-Perme estimator. For trend analyses, the study period was specific to each country. The results are reported from 1992 to 2004 in France, Italy, Spain and Switzerland and from 2000 to 2004 in Belgium and Portugal...
January 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28004135/nodal-parameters-of-fdg-pet-ct-performed-during-radiotherapy-for-locally-advanced-mucosal-primary-head-and-neck-squamous-cell-carcinoma-can-predict-treatment-outcomes-suvmean-and-response-rate-are-useful-imaging-biomarkers
#12
Peter Lin, Myo Min, Mark Lee, Lois Holloway, Dion Forstner, Victoria Bray, Allan Fowler
PURPOSE: To evaluate the prognostic utility of nodal metabolic parameters derived from FDG PET/CT performed before radiotherapy (prePET) and during the third week of radiotherapy (iPET) in patients with mucosal primary head and neck squamous cell carcinoma (MPHNSCC). METHODS: This analysis included 75 patients with newly diagnosed locally advanced node-positive MPHNSCC treated with radical radiotherapy and concurrent systemic therapy who underwent prePET and iPET: N1 11 patients, N2a 38, N2b 12, N2c 9, N3 5...
December 21, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28000247/investigation-of-nutritional-status-using-the-mini-nutritional-assessment-short-form-and-analysis-of-the-relevant-factors-in-patients-with-head-and-neck-tumour
#13
Ayaka Yanagi, Mai Murase, Yuka I Sumita, Hisashi Taniguchi
OBJECTIVE: The aims of this study were to reveal the nutritional status of patients after head and neck tumour treatment by using the Mini Nutritional Assessment-Short Form (MNA-SF) and to analyse the factors affecting nutritional status in patients with head and neck tumour. BACKGROUND: Elderly patients with loss of teeth and maxillary/mandibular bone due to head and neck tumour treatment could be at high risk of malnutrition. However, there are few reports on the nutritional status of these patients...
December 20, 2016: Gerodontology
https://www.readbyqxmd.com/read/27993569/a-genome-based-model-for-adjusting-radiotherapy-dose-gard-a-retrospective-cohort-based-study
#14
Jacob G Scott, Anders Berglund, Michael J Schell, Ivaylo Mihaylov, William J Fulp, Binglin Yue, Eric Welsh, Jimmy J Caudell, Kamran Ahmed, Tobin S Strom, Eric Mellon, Puja Venkat, Peter Johnstone, John Foekens, Jae Lee, Eduardo Moros, William S Dalton, Steven A Eschrich, Howard McLeod, Louis B Harrison, Javier F Torres-Roca
BACKGROUND: Despite its common use in cancer treatment, radiotherapy has not yet entered the era of precision medicine, and there have been no approaches to adjust dose based on biological differences between or within tumours. We aimed to assess whether a patient-specific molecular signature of radiation sensitivity could be used to identify the optimum radiotherapy dose. METHODS: We used the gene-expression-based radiation-sensitivity index and the linear quadratic model to derive the genomic-adjusted radiation dose (GARD)...
December 18, 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27988199/desmoid-tumours-of-the-head-and-neck-in-children-review-of-management
#15
M Risoud, G Mortuaire, X Leroy, P Leblond, P Fayoux
OBJECTIVE: Desmoid tumours of the head and neck in children are rare, local invasive and potentially fatal tumours. The purpose of this review is to discuss the management of these tumours in the light of a case series and a review of the literature. MATERIAL AND METHODS: This retrospective study summarised the medical data of children treated for desmoid tumours of the head and neck between 1976 and 2014. RESULTS: Five of the 6 children were treated by radical surgical resection, with positive surgical margins (R1) in 2 cases, followed by recurrence requiring further resection...
December 14, 2016: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/27974071/cervical-lymph-node-metastasis-in-adenoid-cystic-carcinoma-of-the-major-salivary-glands
#16
(no author information available yet)
OBJECTIVE: To verify the prevalence of cervical lymph node metastasis in adenoid cystic carcinoma of major salivary glands, and to establish recommendations for elective neck treatment. METHODS: A search was conducted of the US National Library of Medicine database. Appropriate articles were selected from the abstracts, and the original publications were obtained to extract data. RESULTS: Among 483 cases of major salivary gland adenoid cystic carcinoma, a total of 90 (18...
December 15, 2016: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27943254/minimally-invasive-surgery-versus-radiotherapy-chemoradiotherapy-for-small-volume-primary-oropharyngeal-carcinoma
#17
REVIEW
James Howard, Liam Masterson, Raghav C Dwivedi, Faruque Riffat, Richard Benson, Sarah Jefferies, Piyush Jani, James R Tysome, Chris Nutting
BACKGROUND: More than 400,000 cases of oropharyngeal squamous cell carcinoma (OPSCC) are diagnosed each year worldwide and the incidence is rising, partly as a result of human papillomavirus. Human papillomavirus-associated OPSCC affects younger patients and often presents at a higher stage; however, it is associated with a better prognosis.Until recently, first-line management of OPSCC involved chemoradiotherapy, as research had demonstrated comparable survival outcomes when compared with open surgery, with significantly decreased morbidity...
December 11, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27941336/a-feed-forward-regulatory-loop-between-hur-and-the-long-noncoding-rna-hotair-promotes-head-and-neck-squamous-cell-carcinoma-progression-and-metastasis
#18
Cheng-Zhi Xu, Chenyan Jiang, Qingwei Wu, Liu Liu, Xiaojun Yan, Runjie Shi
BACKGROUND/AIMS: The lncRNA Homeobox (HOX) transcript antisense RNA (HOTAIR) is overexpressed in numerous cancers. HuR is also overexpressed during tumourigenesis and is abnormally present within the cytoplasm, where it binds to AU-rich elements in the 3'UTRs of target mRNA and post-transcriptionally regulates the expression of its target genes. However, whether HOTAIR is regulated and the mechanisms by which it affects head and neck squamous cell carcinoma (HNSCC) are not well understood...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27939001/the-association-between-human-papillomavirus-and-oropharyngeal-squamous-cell-carcinoma-reviewed-according-to-the-bradford-hill-criteria-for-causality
#19
REVIEW
Lena Walvik, Amanda Björk Svensson, Jeppe Friborg, Christel Bræmer Lajer
There is emerging evidence of the association between human papillomavirus and a subset of head and neck cancers. However, the role of human papillomavirus as a causal factor is still debated. This review addresses the association between human papillomavirus and oropharyngeal squamous cell carcinoma using the Bradford Hill criteria. The strength of the association is supported by, detection of human papillomavirus infection and antibodies prior to oropharyngeal squamous cell carcinoma. This is furthermore reinforced by the absence of human papillomavirus DNA in healthy tonsils...
December 2016: Oral Oncology
https://www.readbyqxmd.com/read/27934959/hopx-functions-as-a-tumour-suppressor-in-head-and-neck-cancer
#20
Lee Fah Yap, Sook Ling Lai, Sathya Narayanan Patmanathan, Ravindran Gokulan, C Max Robinson, Joe B White, San Jiun Chai, Pathmanathan Rajadurai, Narayanan Prepageran, Yew Toong Liew, Victor Lopes, Wenbin Wei, Robert J Hollows, Paul G Murray, Daniel W Lambert, Keith D Hunter, Ian C Paterson
Head and neck squamous cell carcinoma (HNSCC) is generalized term that encompasses a diverse group of cancers that includes tumours of the oral cavity (OSCC), oropharynx (OPSCC) and nasopharynx (NPC). Genetic alterations that are common to all HNSCC types are likely to be important for squamous carcinogenesis. In this study, we have investigated the role of the homeodomain-only homeobox gene, HOPX, in the pathogenesis of HNSCC. We show that HOPX mRNA levels are reduced in OSCC and NPC cell lines and tissues and there is a general reduction of HOPX protein expression in these tumours and OPSCCs...
December 9, 2016: Scientific Reports
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