keyword
https://read.qxmd.com/read/38535990/rna-splicing-regulator-eif3d-regulates-the-tumor-microenvironment-through-immunogene-related-alternative-splicing-in-head-and-neck-squamous-cell-carcinoma
#1
JOURNAL ARTICLE
Dandan Lu, Mijti Mihoayi, Yimin Ablikim, Abdeyrim Arikin
Study finds that eukaryotic translation initiation factor 3 subunit D (EIF3D) may play an important role in aberrant alternative splicing (AS) events in tumors. AS possesses a pivotal role in both tumour progression and the constitution of the tumour microenvironment (TME). Regrettably, our current understanding of AS remains circumscribed especially in the context of immunogene-related alternative splicing (IGAS) profiles within Head and Neck Squamous Cell Carcinoma (HNSC). In this study, we comprehensively analyzed the function and mechanism of action of EIF3D by bioinformatics analysis combined with in vitro cellular experiments, and found that high expression of EIF3D in HNSC was associated with poor prognosis of overall survival (OS) and progression-free survival (PFS)...
March 25, 2024: Aging
https://read.qxmd.com/read/38531998/is-there-an-advantage-to-delayed-molar-implant-placement-in-those-with-chronic-apical-periodontitis
#2
JOURNAL ARTICLE
Rabab Ahmad
DESIGN: This paper is a single-centre, double-blinded, prospective randomised control trial, comparing immediate vs delayed implant placement clinically and radiographically in patients with chronic periodontitis, specifically assessing the molar region. Seventy-four patients were recruited to the study over a one-year period, all of whom returned for follow up throughout the study. STUDY SELECTION: The study adhered to the principles outlined in the Declaration of Helsinki and obtained ethical approval from the affiliated University Hospital of Qingdao...
March 26, 2024: Evidence-based Dentistry
https://read.qxmd.com/read/38530298/comparison-of-semi-automatic-and-manual-segmentation-methods-for-tumor-delineation-on-head-and-neck-squamous-cell-carcinoma-hnscc-positron-emission-tomography-pet-images
#3
JOURNAL ARTICLE
Mahima Merin Philip, Jessica Watts, Seyedeh Niki Mir Moeini, Mohammed Musheb, Fergus McKiddie, Andy Welch, Mintu Nath
Accurate and reproducible tumor delineation on Positron Emission Tomography (PET) images is required to validate predictive and prognostic models based on PET radiomic features. Manual segmentation of tumors is time-consuming whereas semi-automatic methods are easily implementable and inexpensive. This study assessed the reliability of semi-automatic segmentation methods over manual segmentation for tumor delineation in Head and Neck Squamous Cell Carcinoma (HNSCC) PET images.

Approach: We employed manual and six semi-automatic segmentation methods (Just Enough Interaction (JEI), watershed, grow from seeds (GfS), flood filling (FF), 30% SUVmax and 40%SUVmax threshold) using 3D slicer software to extract 128 radiomic features from FDG-PET images of 100 HNSCC patients independently by three operators...
March 26, 2024: Physics in Medicine and Biology
https://read.qxmd.com/read/38529451/incidental-cytodiagnosis-of-carotid-body-tumour-on-fine-needle-aspiration-cytology
#4
Sreetama Mukherjee, Arvind Bhake
A carotid body tumor is a rare form of neoplasm that arises near the carotid artery bifurcation and it has an incidence rate of less than 0.3 per 100,000 population. The low incidence rate of such tumors is due to their origination from the paraganglion cells which is relatively uncommon as compared to other forms of tumor. Here we present an incidental and unusual cytodiagnosis of carotid body tumors. A 45-year-old male presented to the surgery outpatient department with swelling in the left-sided anterior region of the neck...
February 2024: Curēus
https://read.qxmd.com/read/38528037/comparative-response-to-pdt-with-methyl-aminolevulinate-and-temoporfin-in-cutaneous-and-oral-squamous-cell-carcinoma-cells
#5
JOURNAL ARTICLE
J Nicolás-Morala, M Alonso-Juarranz, A Barahona, S Terrén, S Cabezas, F Falahat, Y Gilaberte, S Gonzalez, A Juarranz, M Mascaraque
Cutaneous and Head and Neck squamous cell carcinoma (CSCC, HNSCC) are among the most prevalent cancers. Both types of cancer can be treated with photodynamic therapy (PDT) by using the photosensitizer Temoporfin in HNSCC and the prodrug methyl-aminolevulinate (MAL) in CSCC. However, PDT is not always effective. Therefore, it is mandatory to correctly approach the therapy according to the characteristics of the tumour cells. For this reason, we have used cell lines of CSCC (A431 and SCC13) and HNSCC (HN5 and SCC9)...
March 25, 2024: Scientific Reports
https://read.qxmd.com/read/38524071/the-relationship-of-grade-stage-and-tobacco-usage-in-head-and-neck-squamous-cell-carcinoma-with-p53-pik3ca-and-microrna-profiles
#6
JOURNAL ARTICLE
Kamini Kiran, Nilotpal Chowdhury, Ashok Singh, Manu Malhotra, Sanjeev Kishore
BACKGROUND:  Head and neck squamous cell carcinoma (HNSCC) has multiple epigenetic modifications including post-transcriptional regulation by microRNAs (miRNAs) as well as alterations in molecular pathways due to mutations. Examining these miRNAs and location-specific molecular alterations is essential to understanding the intricacies of HNSCC and directing focused diagnoses and treatments. AIM:  To investigate tobacco-related changes in the expression of miRNAs and proteins with clinicopathological parameters of HNSCC and disease-modifying personal habits like tobacco and alcohol use...
February 2024: Curēus
https://read.qxmd.com/read/38519383/how-long-does-contouring-really-take-results-of-the-royal-college-of-radiologists-contouring-surveys
#7
JOURNAL ARTICLE
E Montague, T Roques, K Spencer, A Burnett, J Lourenco, N Thorp
AIMS: The success and safety of modern radiotherapy relies on accurate contouring. Understanding the time taken to complete radiotherapy contours is critical to informing workforce planning and, in the context of a workforce shortfall, advocating for investment in technology and multi-professional skills mix. We aimed to quantify the time taken to delineate target volumes for radical radiotherapy. MATERIALS AND METHODS: The Royal College of Radiologists circulated two electronic surveys via email to all clinical oncology consultants in the UK...
March 15, 2024: Clinical Oncology: a Journal of the Royal College of Radiologists
https://read.qxmd.com/read/38514926/fucoidan-suppresses-proliferation-and-epithelial-mesenchymal-transition-process-via-wnt-%C3%AE-catenin-signalling-in-hemangioma
#8
JOURNAL ARTICLE
Zhengyumeng Zhu, Jialiang Luo, Lei Li, Di Wang, Qishan Xu, Jianan Teng, Jia Zhou, Ledong Sun, Nansheng Yu, Daming Zuo
Hemangioma is a common benign tumour that usually occurs on the skin of the head and neck, particularly among infants. The current clinical treatment against hemangioma is surgery excision, however, application of drug is a safer and more economical therapy for children suffering from hemangioma. As a natural sulfated polysaccharide rich in brown algae, fucoidan is widely recognized for anti-tumour bioactivity and dosage safety in humans. This study aims to demonstrate the anti-tumour effect and underlying mechanism of fucoidan against hemangioma in vivo and in vitro...
March 2024: Experimental Dermatology
https://read.qxmd.com/read/38514776/impact-of-the-covid-19-pandemic-on-stage-and-incidence-of-head-and-neck-cancer-a-rapid-review-and-meta-analysis
#9
REVIEW
Kelten Clements, Alekh Thapa, Anna Cowell, David Conway, Catriona M Douglas, Claire Paterson
OBJECTIVES: This rapid review aims to evaluate the impact of the COVID-19 pandemic on incidence of head and neck cancer (HNC) and stage distribution at diagnosis. DESIGN: Rapid review and meta-analysis. PARTICIPANTS: Comparative data for new HNC patients between a pre-pandemic cohort (before March 2020) and a pandemic cohort (after March 2020 during the lockdown period). MAIN OUTCOMES MEASURED: Data on tumour stage, incidence, referral pathway (number of new patient referrals), or workload levels (number of HNC treatments)...
March 21, 2024: Clinical Otolaryngology
https://read.qxmd.com/read/38513311/twelve-years-after-the-french-national-network-on-rare-head-and-neck-tumours-refcor
#10
JOURNAL ARTICLE
Cassandre Gasne, Sarah Atallah, Etienne Dauzier, Juliette Thariat, Nicolas Fakhry, Benjamin Verillaud, Marion Classe, Sebastien Vergez, Antoine Moya-Plana, Valerie Costes-Martineau, Christian Righini, Ludovic de Gabory, Laurence Digue, Charles Dupin, François Régis Ferrand, Caroline Even, Bertrand Baujat
BACKGROUND: Rare cancers constitute less than 10% of head and neck cancers and lack sufficient evidence for standardized care. The French Rare Head and Neck Cancer Expert Network (REFCOR) as established a national database to collect data on these rare cancers. This study aims to describe patient and tumour characteristics in this database. METHODS: Prospective data collection was conducted across multiple centers. Survival analyses were performed using Kaplan Meier method and Log Rank test...
March 20, 2024: Oral Oncology
https://read.qxmd.com/read/38510366/best-practices-and-future-challenges-in-the-treatment-of-oral-cancer
#11
JOURNAL ARTICLE
Juliane Kröplin, Jil-Charlot Reppenhagen
OBJECTIVES: Oral cancer is among the most common tumour worldwide. Due to the anatomical peculiarities of the head and neck region, the treatment of oral cancer is a major challenge with regard to the preservation of aesthetics and function. The aim of the present study is to analyze currently practiced therapeutic strategies as well as current and future challenges in the therapy of oral cancer. METHODS: A Pubmed-based selective literature search was performed considering literature predominantly from 2021 to 2022...
December 2023: Innovative Surgical Sciences
https://read.qxmd.com/read/38506408/advances-in-testing-for-human-papillomavirus-mediated-head-and-neck-cancer
#12
JOURNAL ARTICLE
Hisham Mehanna, Laia Alemany, Christian von Buchwald
PURPOSE OF REVIEW: New evidence has recently emerged regarding the utility and benefits of dual p16INKa (p16) and Human papillomavirus (HPV) status testing when determining the diagnosis and prognosis of patients with oropharyngeal cancer. RECENT FINDINGS: HPV RNA polymerase chain reaction (PCR) is the most accurate diagnostic test. The other assays (HPV DNA PCR, HPV DNA/RNA in-situ hybridization (ISH) and p16) applied to formalin fixed tumour tissue have varying but high sensitivities and specificities...
March 20, 2024: Current Opinion in Oncology
https://read.qxmd.com/read/38501009/metabolism-associated-molecular-classification-and-prognosis-signature-of-head-and-neck-squamous-cell-carcinoma
#13
JOURNAL ARTICLE
Mengxian Jiang, Xiang Gu, Yexing Xu, Jing Wang
Although the fundamental processes and chemical changes in metabolic programs have been elucidated in many cancers, the expression patterns of metabolism-related genes in head and neck squamous cell carcinoma (HNSCC) remain unclear. The mRNA expression profiles from the Cancer Genome Atlas included 502 tumour and 44 normal samples were extracted. We explored the biological functions and prognosis roles of metabolism-associated genes in patients with HNSCC. The results indicated that patients with HNSCC could be divided into three molecular subtypes (C1, C2 and C3) based on 249 metabolism-related genes...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38495750/tumour-recurrence-depth-of-invasion-and-temple-location-as-independent-prognostic-parameters-of-lymph-node-metastases-of-head-and-neck-cutaneous-squamous-cell-carcinomas
#14
JOURNAL ARTICLE
Zuzana Horakova, Ivo Starek, Jana Zapletalova, Richard Salzman
The excellent survival rate of cutaneous squamous cell carcinoma (cSCC) exceeding 90% is reduced by the presence of nodal metastases by over 50%. We analysed various risk parameters of cSCC to predict the incidence of nodal metastases. A total of 118 patients with the head cSCC were included in a single-institution retrospective study covering the period from 2008 to 2020. Tumour recurrence, temple location, and tumour infiltration depth were found to be independent predictors of nodal metastases (increasing the probability of metastases by 8...
2024: International Journal of Clinical Practice
https://read.qxmd.com/read/38494409/guided-placement-of-zygomatic-implants-in-head-and-neck-cancer-patients-implant-survival-and-patient-outcomes-at-1-3-years-of-follow-up
#15
JOURNAL ARTICLE
N Vosselman, J Kraeima, K Ng Wei Siang, G M Raghoebar, M J H Witjes, S A H J de Visscher
Zygomatic implants (ZI) are a valuable option for supporting an obturator prosthesis after maxillary resection. This study was performed to assess the clinical outcomes of a digitally validated guided technique for ZI placement, followed by immediate prosthetic obturation. The primary objective was to evaluate implant survival, while the secondary objective was to assess patient-reported quality of life post-rehabilitation. Twelve patients treated for head and neck cancer received a total of 36 ZI after ablative surgery...
March 16, 2024: International Journal of Oral and Maxillofacial Surgery
https://read.qxmd.com/read/38491080/effect-of-radiotherapy-on-head-and-neck-cancer-tissues-in-patients-receiving-radiotherapy-a-bioinformatics-analysis-based-study
#16
JOURNAL ARTICLE
Zhenjie Guan, Jie Liu, Lian Zheng
Radiotherapy is pivotal in treating head and neck cancers including nasopharyngeal, tongue, hypopharyngeal, larynx, maxillary sinus, parotid gland, and oral cancers. It holds the potential for curative effects and finds application in conjunction with chemotherapy, either as a radical method to preserve organ function or as an adjuvant postoperative treatment. We used bioinformatics analysis to investigate the effects of radiotherapy on head and neck cancer tissues in patients who had received radiotherapy...
March 15, 2024: Scientific Reports
https://read.qxmd.com/read/38487394/bilateral-carotid-body-tumours-a-case-report-from-surgeon-s-perspective
#17
Kishen Raj Chandra Sakaran, Toot Tiew, Khidhir Kamil, Hisham Arshad Habeebullah Khan, Mohamad Azim Idris, Lenny Suryani Safri
Carotid body tumour (CBT) is the most common paraganglioma of the head and neck and may compromise neurovascular structures such as carotid vessels, and cranial nerves. Intracranial extension from the mass is possible if left untreated. The main treatment for CBT is surgical resection albeit extremely challenging due to tumour hypervascularity and its relationship to the carotid artery. A bilateral CBT, however, is a rare occurrence. Herein, we present a case of a man who presented to us with bilateral painless and palpable neck mass...
March 2024: Journal of Surgical Case Reports
https://read.qxmd.com/read/38486204/adult-head-and-neck-rhabdomyosarcoma-radiotherapy-based-treatment-outcomes-and-predictors-of-survival
#18
JOURNAL ARTICLE
Dan Zhao, Fang Zhou, Weixin Liu, Zhou Huang, Xiaolong Xu, Baomin Zheng, Changqing Liu, Chujie Bai, Jiayong Liu, Yan Sun, Weihu Wang, Shaowen Xiao
BACKGROUND: Adult head and neck rhabdomyosarcoma (HNRMS) is an exceptionally rare malignancy, and there is a paucity of data and research dedicated to understanding its characteristics and management in adult populations. This study aimed to assess the outcomes and identify survival predictors in adult HNRMS. METHODS: We retrospectively evaluated 42 adult patients (> 16 years) with HNRMS who received radiotherapy (RT)-based treatment at our institute between 2008 and 2022...
March 14, 2024: BMC Cancer
https://read.qxmd.com/read/38483241/dermatoscopic-patterns-of-cutaneous-metastases-a-multicentre-cross-sectional-study-of-the-international-dermoscopy-society
#19
JOURNAL ARTICLE
Danica Tiodorovic, Jelena Stojkovic-Filipovic, Ashfaq Marghoob, Giuseppe Argenziano, Susana Puig, Josep Malvehy, Linda Tognetti, Rubegni Pietro, Bengu Nisa Akay, Iris Zalaudek, Holger A Haenssle, Christine Müller-Christmann, Elisa Cinotti, Jean Luc Perrot, Pedro Zaballos, Renato Marchiori Bakos, Luc Thomas, Ketty Peris, Aimilios Lallas, Zoe Apalla, Juergen F Kreusch, Isabelle Tromme, Alexandros J Stratigos, Maria Antonietta Pizzichetta, Lidija Kandolf, Caterina Longo, Andreas Blum, Masaru Tanaka, Rainer Hofmann-Wellenhof, Andrija Jovic, John Paoli, Marija Buljan, Martina Espasandín-Arias, Horacio Cabo, Sonia Rodrigiez Saa, Gabriel Salerni, Gianluca Nazzaro, Grazyna Kaminska-Winciorek, Giovanni Damiani, Franciska Geszti, Harald Kittler
BACKGROUND: The detection of cutaneous metastases (CMs) from various primary tumours represents a diagnostic challenge. OBJECTIVES: Our aim was to evaluate the general characteristics and dermatoscopic features of CMs from different primary tumours. METHODS: Retrospective, multicentre, descriptive, cross-sectional study of biopsy-proven CMs. RESULTS: We included 583 patients (247 females, median age: 64 years, 25%-75% percentiles: 54-74 years) with 632 CMs, of which 52...
March 14, 2024: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/38481240/lymphatic-drainage-of-sinonasal-malignancies-and-the-role-of-sentinel-node-biopsies
#20
JOURNAL ARTICLE
Fatemeh Kashani, B G Weiss, P Bartenstein, M Canis, F Haubner
BACKGROUND: Locoregional recurrence is a critical factor in the prognosis of sinonasal malignancies. Due to the rarity of these tumours, as well as the heterogeneity of histologies and anatomical subsites, there is little evidence regarding the rate and location of regional metastases in sinonasal malignancies. Elective regional lymph node dissection in the therapy of sinonasal malignancies has become controversial. On the one hand, elective regional lymph node dissection is considered to be an overtreatment in the cN0 cases...
March 13, 2024: Orphanet Journal of Rare Diseases
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