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head and neck tumours

Shanshan Wu, Wanjiao Li, Qiongxiao Zhang, Shuting Li, Lizi Wang
AIM: To compare peripheral arm ports versus central chest ports in complication rates. BACKGROUND: Late complications of arm ports versus chest ports, including catheter-related infection, venous thrombosis and catheter obstruction, remain controversial. DESIGN: A meta-analysis conducted following the Cochrane handbook. DATA SOURCES: Studies published between 1950 - August 2017 were searched through Pubmed, Embase, Web of science and Cochrane library...
June 19, 2018: Journal of Advanced Nursing
Rama Jayaraj, Chellan Kumarasamy, Madhav Madurantakam Royam, Arikketh Devi, Siddharta Baxi
The study performed by Zhou et al. (World J Surg Oncol 15:104, 2017) titled "Clinical and prognostic significance of HIF-1α overexpression in oral squamous cell carcinoma: a meta-analysis" attempts to highlight hypoxia-inducible factor-1 alpha as a possible prognostic marker in oral squamous cell carcinoma (OSCC). We would like to underline a few points which may affect such a conclusion. The correlations between HIF-1α expression and tumour size as well as tumour stage are debatable. Further, the subgroup analysis incorporating Australia and Europe into a single subgroup limits the viability of the prognostic analysis of HIF-1α...
June 18, 2018: World Journal of Surgical Oncology
Piotr Wranicz, Bente Brokstad Herlofson, Jan F Evensen, Ulf E Kongsgaard
Introduction Trismus, or limited mouth opening, is a well-known complication of head and neck cancer and its treatment. It may be caused by tumour infiltration into the masticatory muscles or by treatment like surgery and radiotherapy. A limited mouth opening may have a negative effect on nutrition, phonation, dental hygiene and treatment, and quality of life. The severity of this complication depends on the location of the tumour, the type of reconstruction, the total radiation dose, fractionation, and treatment techniques...
December 29, 2017: Scandinavian Journal of Pain
Katherine Pollaers, Anton Hinton-Bayre, Peter L Friedland, Camile S Farah
OBJECTIVES: To explore the prognostic and discriminatory ability of the AJCC 8th Edition Oral Cavity cancer staging in a non-North American population, and compare it to the previously used AJCC 7th Edition. MATERIALS AND METHODS: Retrospective chart review was performed at a tertiary referral Otolaryngology, Head Neck and Skull Base Department in Australia, from June 2002 to June 2017. Oral cavity squamous cell carcinoma cases were staged according to AJCC 8th Edition, which was compared to AJCC 7th Edition staging, for disease-free survival (DFS) and overall survival (OS)...
July 2018: Oral Oncology
James Best, Charles Fong, Helen Benghiat, Hisham Mehanna, John Glaholm, Andrew Hartley
Background: The effect of synchronous chemotherapy in squamous cell carcinoma of the head and neck (SCCHN) has been modelled as additional Biologically Effective Dose (BED) or as a prolonged tumour cell turnover time during accelerated repopulation. Such models may not accurately predict the local control seen when hypofractionated accelerated radiotherapy is used with synchronous chemotherapy. Methods: For the purposes of this study three isoeffect relationships were assumed: Firstly, from the RTOG 0129 trial, synchronous cisplatin chemotherapy with 70 Gy in 35 fractions over 46 days results in equivalent local control to synchronous cisplatin chemotherapy with 36 Gy in 18# followed by 36 Gy in 24# (2# per day) over a total of 39 days...
June 13, 2018: Medicines (Basel, Switzerland)
Joanna Katarzyna Strzelczyk, Łukasz Krakowczyk, Aleksander Jerzy Owczarek
Oral cavity cancer is a type of head and neck squamous cell carcinoma (HNSCC) and contributes to significant morbidity and mortality each year. An epigenetic pathway of transcriptional inactivation for many genes has been described in various cancers, including HNSCC. For our study, we selected genes for which silencing caused by hypermethylation can promote cancer development. In 75 primary HNSCC tumours and paired surgical margins, we investigated the methylation status of the p16, APC, MGMT, TIMP3 and CDH1 gene promoters by methylation-specific PCR after bisulphite treatment...
2018: Journal of Cancer
Olalla Santa Cruz, Pelagia Tsoutsou, Cyril Castella, Kaouthar Khanfir, Sandro Anchisi, Salim Bouayed, Oscar Matzinger, Mahmut Ozsahin
OBJECTIVES: To assess the feasibility and efficacy of intensity-modulated radiation implemented with helical tomotherapy image-guided with daily megavoltage computed tomography for head and neck cancer. METHODS: Between May 2010 and May 2013, 72 patients were treated with curative intent. The median age was 64 years, with 57% undergoing definitive and 43% postoperative radiotherapy. Primary tumour sites were oral cavity (21%), oropharynx (26%), hypopharynx (20%), larynx (22%), and others (11%)...
June 12, 2018: Oncology
Neslihan Kurtul, Nursel Yurttutan, Murat Baykara
OBJECTIVE: The aim of this study was to apply texture analysis to investigate whether there was a change in the lens following radiotherapy. PATIENTS AND METHOD: Patients who received radiotherapy (RT) for head and neck cancer or brain tumour were enrolled. Computed tomography (CT) images taken one month before RT and the most recent images after RT were compared. Entropy values were calculated using lens attenuation values. The lens doses were obtained from the dose-volume histogram data...
June 5, 2018: Journal of X-ray Science and Technology
Amrendra Mishra, Harshini Sriram, Pinal Chandarana, Vivek Tanavde, Rekha V Kumar, Ashok Gopinath, Raman Govindarajan, S Ramaswamy, Subhashini Sadasivam
The goal of this study was to isolate cancer stem-like cells marked by high expression of CD44, a putative cancer stem cell marker, from primary oral squamous cell carcinomas and identify distinctive gene expression patterns in these cells. From 1 October 2013 to 4 September 2015, 76 stage III-IV primary oral squamous cell carcinoma of the gingivobuccal sulcus were resected. In all, 13 tumours were analysed by immunohistochemistry to visualise CD44-expressing cells. Expression of CD44 within The Cancer Genome Atlas-Head and Neck Squamous Cell Carcinoma RNA-sequencing data was also assessed...
May 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Nivedita Sharma, Nebu Abraham George, Rajesh Singh, Elizabeth Mathew Iype, Bipin T Varghese, Shaji Thomas
Head and neck soft tissue sarcoma (HNSTS) is a rare neoplasm accounting for 1% of all head and neck tumours. Because of rarity and varied biological behaviour among various subtypes, knowledge about these tumours is limited. This study aimed at analysing clinicopathological, recurrence and survival pattern of surgically treated HNSTS. Case records of 28 patients of HNSTS who underwent surgery at the Regional Cancer Centre (RCC), Trivandrum (India) between 2002 and 2012 were analysed retrospectively for demographic profile, clinical features, treatment given, recurrence pattern and outcome...
June 2018: Indian Journal of Surgical Oncology
J Kraeima, B Dorgelo, H A Gulbitti, R J H M Steenbakkers, K P Schepman, J L N Roodenburg, F K L Spijkervet, R H Schepers, M J H Witjes
OBJECTIVES: 3D virtual surgical planning (VSP) and guided surgery has been proven to be an effective tool for resection and reconstruction of the mandible. Currently, most widely used 3D VSP approaches to mandibular resection do not include detailed tumour information in the VSP. This manuscript presents a strategy where the aim was to incorporate tumour visualisation into the 3D virtual plan. Three-dimensional VSP of the mandibular resections was based on the fusion of CT and MRI data which was subsequently applied in clinical practice...
June 2018: Oral Oncology
Sameh Attia, Joerg Wiltfang, Jörn Pons-Kühnemann, Jan-Falco Wilbrand, Philipp Streckbein, Christopher Kähling, Hans-Peter Howaldt, Heidrun Schaaf
PURPOSE: Ablative oncological surgery to treat head-and-neck cancer often triggers a requirement for jaw reconstruction. Modern surgical procedures using free microvascular flaps afford acceptable outcomes in terms of restoration of bony and soft tissue defects. A fibula free flap is often the preferred flap, as the bone length is considerable and a two-surgeon approach is possible. Dental implants play important roles in functional rehabilitation. Our aim was to evaluate the survival of dental implants placed in reconstructed areas after transfer of fibula tissue to the jaw...
June 5, 2018: Journal of Cranio-maxillo-facial Surgery
Maria Luisa Belli, Martina Mori, Sara Broggi, Giovanni Mauro Cattaneo, Valentino Bettinardi, Italo Dell'Oca, Federico Fallanca, Paolo Passoni, Emilia Giovanna Vanoli, Riccardo Calandrino, Nadia Di Muzio, Maria Picchio, Claudio Fiorino
PURPOSE: To investigate the robustness of PET radiomic features (RF) against tumour delineation uncertainty in two clinically relevant situations. METHODS: Twenty-five head-and-neck (HN) and 25 pancreatic cancer patients previously treated with 18 F-Fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT)-based planning optimization were considered. Seven FDG-based contours were delineated for tumour (T) and positive lymph nodes (N, for HN patients only) following manual (2 observers), semi-automatic (based on SUV maximum gradient: PET_Edge) and automatic (40%, 50%, 60%, 70% SUV_max thresholds) methods...
May 2018: Physica Medica: PM
D Peiffert, B Coche-Dequéant, M Lapeyre, S Renard
The main indications of the brachytherapy of head and neck cancers are the limited tumours of the lip, the nose, the oral cavity and the oropharynx. Nasopharynx tumours are nowadays treated by intensity-modulated radiotherapy. This technique can be exclusive, associated with external radiotherapy or postoperative. It can also be a salvage treatment for the second primaries in previously irradiated areas. If the low dose rate brachytherapy rules remain the reference, the pulse dose rate technique allows the prescription of the dose rate and the optimisation of the dose distribution...
May 29, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
Bader Mohammed Alim, Mohammed Jomah, Majid Al-Thobaiti
Schwannoma (neurilemmoma) is a benign tumour that arises from the Schwann cells which cover the nerve sheaths of the peripheral or autonomic nervous system especially the sympathetic system. Reported cases of schwannoma arising from the sinonasal tract are rare. We report a case of a 28-year-old man who presented to otolaryngology-head and neck surgery clinic with left cheek swelling and left-sided nasal obstruction for 1-year period. Endoscopic examination and high-resolution CT scan revealed a homogenous expansile mass occupying the left maxillary antrum extending to the left orbit and left ethmoidal air cells...
May 30, 2018: BMJ Case Reports
Sadaf Batool, Awais Amjad Malik, Hassaan Bari, Irfan Ul Islam, Faisal Hanif
Option for borderline resectable pancreatic cancer is pancreaticoduodenectomy (PD) with vascular resection and reconstruction. We would like to share our experience of vascular reconstruction. First patient was a 51-year male with pancreatic head carcinoma, involving posterior wall of portal vein (PV) and replacing right hepatic artery (RHA). Along with PD, he underwent PV and RHA resection and reconstruction. Second case was a 33-year female who had distal pancreatic cyst and PV-splenic vein junction involved by tumor...
June 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
M Salmivuori, N Neittaanmäki, I Pölönen, L Jeskanen, E Snellman, M Grönroos
BACKGROUND: Basal cell carcinoma (BCC) is the most common skin cancer in the Caucasian population. Eighty percent of BCCs are located on the head and neck area. Clinically ill-defined BCCs often represent histologically aggressive subtypes, and they can have subtle subclinical extensions leading to recurrence and the need for re-excisions. OBJECTIVES: The aim of this pilot study was to test the feasibility of a hyperspectral imaging system (HIS) in vivo in delineating the preoperatively lateral margins of ill-defined BCCs on the head and neck area...
May 30, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Athiva Shankar, Dorothy H Crouch, Michaelina Macluskey
High-risk human papilloma virus (HR-HPV) has increasingly been associated with head and neck squamous cell carcinoma (HNSCC), in particular oropharyngeal cancers. Ezrin-Radixin-Moesin Binding Phosphoprotein 50 (EBP50), a putative tumour suppressor, localises to the plasma membrane in suprabasal epithelium and to the cytoplasm in proliferative basal layers, and is a target for degradation by the HR-HPV E6 oncoprotein. The aim of this study was to investigate EBP50 protein expression patterns in HNSCC in a large Scottish cohort to determine if there was a correlation with HPV status and clinical outcomes...
May 30, 2018: Head and Neck Pathology
Jason K Wasserman, Doaa AlGhamdi, John R de Almeida, Tracy L Stockley, Bayardo Perez-Ordonez
Neuroendocrine carcinomas (NECs) are epithelial neoplasms showing morphologic, immunophenotypic or ultrastructural evidence of neuroendocrine differentiation. The 2017 WHO Classification of Head and Neck Tumours classifies NECs into well, moderately and poorly differentiated NECs according to light microscopic features, mitotic rate and presence of tumour necrosis. In this study, we performed next generation sequencing (NGS) using a targeted 161 cancer gene panel on a poorly differentiated NEC of the nasal cavity...
May 29, 2018: Head and Neck Pathology
P Ahmad, M Slavík, J Šána, M Hermanová, P Šlampa, P Smilek, T Kazda, O Slabý
BACKGROUND: Radiotherapy plays a key role in the treatment of squamous cell head and neck cancers (HNSCC). The effectivity of radiation therapy is often limited by radioresistance of these tumours. microRNAs (miRNAs) are endogenous, evolutionary conserved, small non-coding RNAs involved in regulation of cellular processes associated with radioresistance. The objective of this study was to identify miRNA profile enabling to predict the radiation treatment outcomes in HNSCC patients. MATERIAL AND METHODS: The retrospective study included HNSCC patients who underwent a definitive radiotherapy...
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
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