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https://www.readbyqxmd.com/read/28433854/comorbidity-age-of-onset-and-suicidality-in-obsessive-compulsive-disorder-ocd-an-international-collaboration
#1
V Brakoulias, V Starcevic, A Belloch, C Brown, Y A Ferrao, L F Fontenelle, C Lochner, D Marazziti, H Matsunaga, E C Miguel, Ycj Reddy, M C do Rosario, R G Shavitt, A Shyam Sundar, D J Stein, A R Torres, K Viswasam
OBJECTIVES: To collate data from multiple obsessive-compulsive disorder (OCD) treatment centers across seven countries and five continents, and to report findings in relation to OCD comorbidity, age of onset of OCD and comorbid disorders, and suicidality, in a large clinical and ethnically diverse sample, with the aim of investigating cultural variation and the utility of the psychiatric diagnostic classification of obsessive-compulsive and related disorders. METHODS: Researchers in the field of OCD were invited to contribute summary statistics on current and lifetime psychiatric comorbidity, age of onset of OCD and comorbid disorders and suicidality in their patients with OCD...
April 12, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28412602/secondary-outcomes-from-the-pediatric-obsessive-compulsive-disorder-treatment-study-ii
#2
Christine A Conelea, Robert R Selles, Kristen G Benito, Michael M Walther, Jason T Machan, Abbe M Garcia, Jeffrey Sapyta, Sarah Morris, Martin Franklin, Jennifer B Freeman
The Pediatric Obsessive-Compulsive Disorder Treatment Study II (POTS II) investigated the benefit of serotonin reuptake inhibitor (SRI) augmentation with cognitive behavioral therapy (CBT). Primary outcomes focused on OCD symptom change and indicated benefit associated with a full course of CBT. Given that the majority of youth with OCD suffer from significant comorbid symptoms and impaired quality of life, the current study examined POTS II data for effects on secondary outcomes. Participants were 124 youth ages 7-17 years with a primary diagnosis of OCD who were partial responders to an adequate SRI trial...
April 7, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28386221/deep-brain-stimulation-of-the-nucleus-accumbens-core-affects-trait-impulsivity-in-a-baseline-dependent-manner
#3
Maria C Schippers, Bastiaan Bruinsma, Mathijs Gaastra, Tanja I Mesman, Damiaan Denys, Taco J De Vries, Tommy Pattij
Deep brain stimulation (DBS) of the nucleus accumbens (NA) is explored as a treatment for refractory psychiatric disorders, such as obsessive-compulsive disorder (OCD), depressive disorder (MDD), and substance use disorder (SUD). A common feature of some of these disorders is pathological impulsivity. Here, the effects of NAcore DBS on impulsive choice and impulsive action, two distinct forms of impulsive behavior, were investigated in translational animal tasks, the delayed reward task (DRT) and five-choice serial reaction time task (5-CSRTT), respectively...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28381420/continuum-beliefs-and-stigmatising-beliefs-about-mental-illness-results-from-an-asian-community-survey
#4
Mythily Subramaniam, Edimansyah Abdin, Louisa Picco, Shazana Shahwan, Anitha Jeyagurunathan, Janhavi Ajit Vaingankar, Siow Ann Chong
OBJECTIVES: To establish the prevalence and correlates of continuum beliefs for five mental illnesses in a multiethnic population and to explore its association with stigma. DESIGN: A community-based, cross-sectional study. SETTING: A national study in a multiethnic Asian country. PARTICIPANTS: A comprehensive study of 3006 Singapore residents (Singapore citizens and permanent residents) aged 18-65 years who were living in Singapore at the time of the survey...
April 5, 2017: BMJ Open
https://www.readbyqxmd.com/read/28375061/novel-biotherapies-are-needed-in-youth-mental-health
#5
G Paul Amminger, Maximus Berger, Simon M Rice, Christopher G Davey, Miriam R Schäfer, Patrick D McGorry
Adverse effects and lack of efficacy in a significant number of patients limit pharmaceutical interventions in youth psychiatry. This is exemplified by the fact that no medication is currently approved for the treatment of non-OCD anxiety disorders or major depressive disorder in young people younger than 18 years of age in Australia. Here, emerging biological therapies for youth with mental health problems are discussed. There is an urgent need for more research into biological interventions with acceptable risk-benefit balances...
April 2017: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/28373849/deep-brain-stimulation-in-anorexia-nervosa-hope-for-the-hopeless-or-exploitation-of-the-vulnerable-the-oxford-neuroethics-gold-standard-framework
#6
Rebecca J Park, Ilina Singh, Alexandra C Pike, Jacinta O A Tan
Neurosurgical interventions for psychiatric disorders have a long and troubled history (1, 2) but have become much more refined in the last few decades due to the rapid development of neuroimaging and robotic technologies (2). These advances have enabled the design of less invasive techniques, which are more focused, such as deep brain stimulation (DBS) (3). DBS involves electrode insertion into specific neural targets implicated in pathological behavior, which are then repeatedly stimulated at adjustable frequencies...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28367774/the-singaporean-public-beliefs-about-the-causes-of-mental-illness-results-from-a-multi-ethnic-population-based-study
#7
S Pang, M Subramaniam, S P Lee, Y W Lau, E Abdin, B Y Chua, L Picco, J A Vaingankar, S A Chong
AIMS: To identify the common causal beliefs of mental illness in a multi-ethnic Southeast Asian community and describe the sociodemographic associations to said beliefs. The factor structure to the causal beliefs scale is explored. The causal beliefs relating to five different mental illnesses (alcohol abuse, depression, obsessive-compulsive disorder (OCD), dementia and schizophrenia) and desire for social distance are also investigated. METHODS: Data from 3006 participants from a nationwide vignette-based study on mental health literacy were analysed using factor analysis and multiple logistic regression to address the aims...
April 3, 2017: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/28359017/an-investigation-of-doubt-in-obsessive-compulsive-disorder
#8
Jack Samuels, O Joseph Bienvenu, Janice Krasnow, Ying Wang, Marco A Grados, Bernadette Cullen, Fernando S Goes, Brion Maher, Benjamin D Greenberg, Nicole C McLaughlin, Steven A Rasmussen, Abby J Fyer, James A Knowles, Paul Nestadt, James T McCracken, John Piacentini, Dan Geller, David L Pauls, S Evelyn Stewart, Dennis L Murphy, Yin-Yao Shugart, Vidya Kamath, Arnold Bakker, Mark A Riddle, Gerald Nestadt
BACKGROUND: Clinicians have long considered doubt to be a fundamental characteristic of obsessive-compulsive disorder (OCD). However, the clinical relevance of doubt in OCD has not been addressed. METHODS: Participants included 1182 adults with OCD who had participated in family and genetic studies of OCD. We used a clinical measure of the severity of doubt, categorized as none, mild, moderate, severe, or extreme. We evaluated the relationship between doubt and OCD clinical features, Axis I disorders, personality and personality disorder dimensions, impairment, and treatment response...
May 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28347840/enhanced-action-tendencies-in-obsessive-compulsive-disorder-an-erp-study
#9
Adi Dayan, Andrea Berger, Gideon Emanuel Anholt
Obsessive-compulsive disorder (OCD) is characterized by repeated thoughts and behaviors. This study explored the stages of motor response preparation that precede action performance or inhibition: We investigated whether OCD is related to enhanced action tendencies in response to external stimuli. Response preparation processes were assessed using the event-related potential (ERP) component of the readiness potential (RP). ERPs were recorded while 15 participants with OCD and 16 healthy controls performed a variation of the go/no-go task and the stop-signal task using schematic faces (angry and neutral)...
June 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28342401/sudden-gains-in-exposure-therapy-for-obsessive-compulsive-disorder
#10
Lindsey M Collins, Meredith E Coles
Prior research in the treatment of depression and anxiety has demonstrated that a sudden reduction in symptoms between two consecutive sessions (sudden gain) is related to lower post-treatment symptom severity (e.g. Hofmann, Schulz, Meuret, Moscovitch, & Suvak, 2006; Tang & DeRubeis, 1999). However, only one study has examined sudden gains in the treatment of obsessive compulsive disorder (OCD). In that study, one-third of the patients with OCD experienced a sudden gain (Aderka et al., 2012). Further, patients who had a sudden gain had lower clinician-rated OCD symptom severity post-treatment (Aderka et al...
June 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28341617/internet-delivered-health-interventions-that-work-systematic-review-of-meta-analyses-and-evaluation-of-website-availability
#11
Mary Am Rogers, Kelsey Lemmen, Rachel Kramer, Jason Mann, Vineet Chopra
BACKGROUND: Due to easy access and low cost, Internet-delivered therapies offer an attractive alternative to improving health. Although numerous websites contain health-related information, finding evidence-based programs (as demonstrated through randomized controlled trials, RCTs) can be challenging. We sought to bridge the divide between the knowledge gained from RCTs and communication of the results by conducting a global systematic review and analyzing the availability of evidence-based Internet health programs...
March 24, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28340445/an-updated-meta-analysis-short-term-therapeutic-effects-of-repeated-transcranial-magnetic-stimulation-in-treating-obsessive-compulsive-disorder
#12
REVIEW
Dong-Dong Zhou, Wo Wang, Gao-Mao Wang, Da-Qi Li, Li Kuang
BACKGROUND: This study was conducted to evaluate the short-term therapeutic effects of using repeated transcranial magnetic stimulation (rTMS) to treat obsessive-compulsive disorder (OCD) and to examine potential influencing factors. METHOD: We searched the PubMed, EMBASE, CENTRAL, Wanfang, CNKI, and Sinomed databases on September 18, 2016 and reviewed the references of previous meta-analyses. Sham-controlled, randomized clinical trials using rTMS to treat OCD were included...
March 18, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28319785/the-long-and-complex-road-in-the-search-for-treatment-for-mental-disorders-an-analysis-of-the-process-in-five-groups-of-patients
#13
Gema Del Valle, Amparo Belloch, Carmen Carrió
Seeking treatment for mental-health problems is a complex process, with different underlying motives in each stage. However, the entire process and these motives have hardly been investigated. This study aims to analyze the different stages of the help-seeking process and their underlying motives in five groups of patients with different mental disorders. In all, 156 patients seeking treatment in outpatient mental health clinics were individually interviewed: 71 had Obsessive-Compulsive Disorder (OCD), 21 had Agoraphobia (AGO), 18 had Major Depressive Disorder (MDD), 20 had Anorexia Nervosa (AN), and 22 had Cocaine Dependence (COC)...
March 15, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28279877/a-model-based-analysis-of-decision-making-under-risk-in-obsessive-compulsive-and-hoarding-disorders
#14
Gabriel J Aranovich, Daniel R Cavagnaro, Mark A Pitt, Jay I Myung, Carol A Mathews
Attitudes towards risk are highly consequential in clinical disorders thought to be prone to "risky behavior", such as substance dependence, as well as those commonly associated with excessive risk aversion, such as obsessive-compulsive disorder (OCD) and hoarding disorder (HD). Moreover, it has recently been suggested that attitudes towards risk may serve as a behavioral biomarker for OCD. We investigated the risk preferences of participants with OCD and HD using a novel adaptive task and a quantitative model from behavioral economics that decomposes risk preferences into outcome sensitivity and probability sensitivity...
February 21, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28273489/difficulties-in-emotion-regulation-mediate-negative-and-positive-affects-and-craving-in-alcoholic-patients
#15
Vahid Khosravani, Farangis Sharifi Bastan, Fatemeh Ghorbani, Zoleikha Kamali
The aim of this study was to assess the mediating effects of difficulties in emotion regulation (DER) on the relations of negative and positive affects to craving in alcoholic patients. 205 treatment-seeking alcoholic outpatients were included. DER, positive and negative affects as well as craving were evaluated by the Difficulties in Emotion Regulation Scale (DERS), the Positive/Negative Affect Scales, and the Obsessive Compulsive Drinking Scale (OCDS) respectively. Clinical factors including depression and severity of alcohol dependence were investigated by the Alcohol Use Disorders Identification Test (AUDIT) and the Beck Depression Inventory-II (BDI-II) respectively...
March 2, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28260554/social-anxiety-and-fear-of-causing-discomfort-to-others-diagnostic-specificity-symptom-correlates-and-cbt-treatment-outcome
#16
Yasunori Nishikawa, Judith M Laposa, Rotem Regev, Neil A Rector
BACKGROUND: Patients with social anxiety disorder (SAD) report fear content relating to the perceived aversive consequences of their anxiety for others in their social environment. However, no studies to date have examined the diagnostic specificity of these fears to SAD as well as predictors to treatment response of these fears. AIMS: To examine relative specificity of fears related to causing discomfort to others, as measured by Social Anxiety-Fear of Causing Discomfort to Others (SA-DOS), among patients with anxiety disorders, obsessive compulsive disorder (OCD) and major depressive disorder (MDD), in addition to relation between dysfunctional attitudes and treatment response among patients with SAD...
March 6, 2017: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/28258321/are-lifetime-affective-disorders-predictive-of-long-term-outcome-in-severe-adolescent-anorexia-nervosa
#17
B Carrot, L Radon, T Hubert, S Vibert, J Duclos, F Curt, N Godart
Depression and anxiety are commonly associated with anorexia nervosa (AN) and contribute to difficulties in social integration, a negative factor for outcome in AN. The link between those disorders and AN has been poorly studied. Thus, our objective was to investigate (1) the link between outcome nine years after hospitalisation for AN and the occurrence of lifetime anxious or depressive comorbidities; (2) the prognostic value of these comorbidities on patient outcome; 181 female patients were hospitalised for AN (between 13 and 22 years old), and were re-evaluated for their psychological, dietary, physical and social outcomes, from 6 to 12 years after their hospitalisation...
March 3, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28207915/suicidal-and-death-ideation-among-adults-with-obsessive-compulsive-disorder-presenting-for-intensive-intervention
#18
Eric A Storch, Brian Kay, Monica S Wu, Joshua M Nadeau, Bradley Riemann
BACKGROUND: This study examined the frequency and relation of death and/or suicidal ideation to treatment response in 101 adults with obsessive-compulsive disorder (OCD) presenting for intensive intervention. METHODS: Within 2 days of admission to an intensive treatment program, 101 adults with OCD completed the Yale-Brown Obsessive Compulsive Scale-Self Report, Quick Inventory of Depressive Symptomatology-Self Report, Intolerance of Uncertainty Scale, Obsessive-Compulsive Inventory-Revised, Penn State Worry Questionnaire, and Quality of Life Enjoyment and Satisfaction Questionnaire-Short Form, and were administered the Columbia Suicide Scale by a trained clinician...
February 2017: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/28194835/mindfulness-based-cognitive-therapy-as-an-augmentation-treatment-for-obsessive-compulsive-disorder
#19
Brenda L Key, Karen Rowa, Peter Bieling, Randi McCabe, Elizabeth J Pawluk
A significant number of obsessive-compulsive disorder (OCD) patients continue to experience symptoms that interfere with their functioning following cognitive behavioural therapy (CBT). Providing an additional augmentation treatment following CBT could help reduce these residual symptoms. Mindfulness interventions that facilitate less reactivity to thoughts and feelings may be helpful for patients suffering from residual OCD symptoms. The purpose of the current randomized waitlist control trial was to evaluate the feasibility and impact of providing an 8-week mindfulness-based cognitive therapy (MBCT) intervention following completion of a CBT intervention to OCD patients who continued to suffer from significant symptoms...
February 13, 2017: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/28183286/register-based-study-of-the-incidence-comorbidities-and-demographics-of-obsessive-compulsive-disorder-in-specialist-healthcare
#20
Hanna Rintala, Roshan Chudal, Sami Leppämäki, Susanna Leivonen, Susanna Hinkka-Yli-Salomäki, Andre Sourander
BACKGROUND: Incidence of obsessive-compulsive disorder (OCD) has been suspected to increase but nationwide epidemiological studies are limited. This study aims to examine sex-specific incidence time trends and characterize psychiatric and neurodevelopmental comorbidities and sociodemographic risk factors of OCD in specialist healthcare in Finland. METHODS: A nationwide register-based study using data from four Finnish registers identified 3372 OCD cases and 13,372 matched controls (1:4)...
February 10, 2017: BMC Psychiatry
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