keyword
https://read.qxmd.com/read/38547312/aryl-hydrocarbon-receptor-as-a-drug-target-in-advanced-prostate-cancer-therapy-obstacles-and-perspectives
#1
REVIEW
Jiřina Procházková, Zuzana Kahounová, Jan Vondráček, Karel Souček
Aryl hydrocarbon receptor (AhR) is a transcription factor that is primarily known as an intracellular sensor of environmental pollution. After five decades, the list of synthetic and toxic chemicals that activate AhR signaling has been extended to include a number of endogenous compounds produced by various types of cells via their metabolic activity. AhR signaling is active from the very beginning of embryonal development throughout the life cycle and participates in numerous biological processes such as control of cell proliferation and differentiation, metabolism of aromatic compounds of endogenous and exogenous origin, tissue regeneration and stratification, immune system development and polarization, control of stemness potential, and homeostasis maintenance...
March 28, 2024: Transcription
https://read.qxmd.com/read/38546609/in-vitro-assays-for-immuno-oncology-drug-efficacy-assessment-and-screening-for-personalized-cancer-therapy-scopes-and-challenges
#2
REVIEW
Marufur Rahman, Greg Wells, Juha K Rantala, Thomas Helleday, Munitta Muthana, Sarah J Danson
INTRODUCTION: Immunotherapies have revolutionized cancer treatment, but often fail to produce desirable therapeutic outcomes in all patients. Due to the inter-patient heterogeneity and complexity of the tumor microenvironment, personalized treatment approaches are gaining demand. Researchers have long been using a range of in-vitro assays including 2D models, organoid co-cultures, and cancer-on-a-chip platforms for cancer drug screening. A comparative analysis of these assays with their suitability, high-throughput capacity, and clinical translatability is required for optimal translational use...
March 28, 2024: Expert Review of Clinical Immunology
https://read.qxmd.com/read/38546403/the-necroptosis-related-signature-and-tumor-microenvironment-immune-characteristics-associated-with-clinical-prognosis-and-drug-sensitivity-analysis-in-stomach-adenocarcinoma
#3
JOURNAL ARTICLE
Biao Yang, Yingnan Wang, Tao Liu, Meijing Zhang, Tianhang Luo
PURPOSE: Necroptosis plays an important role in the tumorigenesis, development, metastasis, and drug resistance of malignant tumors. This study explored the new model for assessing stomach adenocarcinoma (STAD) prognosis and immunotherapy by combining long noncoding RNAs associated with necroptosis. METHODS: Patient clinical data and STAD gene expression profiles were curated from The Cancer Genome Atlas (TCGA). Immune-related genes were sourced from a specialized molecular database...
March 27, 2024: Aging
https://read.qxmd.com/read/38546326/meta-dhgnn-method-for-crs-related-cytokines-analysis-in-car-t-therapy-based-on-meta-learning-directed-heterogeneous-graph-neural-network
#4
JOURNAL ARTICLE
Zhenyu Wei, Chengkui Zhao, Min Zhang, Jiayu Xu, Nan Xu, Shiwei Wu, Xiaohui Xin, Lei Yu, Weixing Feng
Chimeric antigen receptor T-cell (CAR-T) immunotherapy, a novel approach for treating blood cancer, is associated with the production of cytokine release syndrome (CRS), which poses significant safety concerns for patients. Currently, there is limited knowledge regarding CRS-related cytokines and the intricate relationship between cytokines and cells. Therefore, it is imperative to explore a reliable and efficient computational method to identify cytokines associated with CRS. In this study, we propose Meta-DHGNN, a directed and heterogeneous graph neural network analysis method based on meta-learning...
March 27, 2024: Briefings in Bioinformatics
https://read.qxmd.com/read/38546054/a-crosstalk-between-the-receptor-tyrosine-kinase-like-orphan-receptors-ror1-2-and-s1p-signaling-pathways-in-lung-cancer
#5
JOURNAL ARTICLE
Rajeev Nema, Ritu Pandey, Ashok Kumar
OBJECTIVE: Availability of multimodal treatment strategies, including targeted therapies and immunotherapies, have improved the survival of non-small cell lung carcinoma (NSCLC). However, some patients still progress or respond poorly due to inherent resistance, acquired resistance, or lack of druggable driver mutations. Sphingosine-1-phosphate (S1P) and receptor tyrosine kinase-like orphan receptor (ROR1/2) signaling pathways are activated during lung carcinogenesis. METHODS: In this study, we have evaluated the crosstalk of S1P and ROR1/2 signaling pathways in lung cancer cells...
March 1, 2024: Asian Pacific Journal of Cancer Prevention: APJCP
https://read.qxmd.com/read/38545939/glutathione-responsive-and-hydrogen-sulfide-self-generating-nanocages-based-on-self-weaving-technology-to-optimize-cancer-immunotherapy
#6
JOURNAL ARTICLE
Shuangquan Gou, Wenbo Geng, Yanan Zou, Fangye Chen, Tingting He, Qiaojian Duan, Zizhen Qin, Liangsheng Li, Jiang Xia, Yongsheng Yu, Qian Feng, Kaiyong Cai
As an ideal drug carrier, it should possess high drug loading and encapsulation efficiency and precise drug targeting release. Herein, we utilized a template-guided self-weaving technology of phase-separated silk fibroin (SF) in reverse microemulsion (RME) to fabricate a kind of hyaluronic acid (HA) coated SF nanocage (HA-gNCs) for drug delivery of cancer immunotherapy. Due to the hollow structure, HA-gNCs were capable of simultaneous encapsulation of the anti-inflammatory drug betamethasone phosphate (BetP) and the immune checkpoint blockade (ICB) agent PD-L1 antibody (αPD-L1) efficiently...
March 28, 2024: ACS Nano
https://read.qxmd.com/read/38545827/nivolumab-as-a-promising-treatment-option-for-metastatic-salivary-duct-carcinoma
#7
JOURNAL ARTICLE
Luis Bugia, Frederic Jungbauer, Lena Zaubitzer, Christian Hörner, Kirsten Merx, Abo-Madyan Yasser, Thomas Germann, Anne Lammert, Claudia Scherl, Nicole Rotter, Annette Affolter
Salivary duct carcinomas (SDC) of the parotid gland are rarely occurring highly malignant tumors. A 65-year-old man presented with a preauricular mass. After surgical treatment and histologic examination, the findings were interpreted as a squamous cell carcinoma (SCC) metastasis of the parotid gland deriving from a cancer of unknown primary DD primary SCC of the parotid gland. Adjuvant platinum-based radiochemotherapy was administered in domo. However, re-staging revealed multiple size-progressive pulmonary round lesions...
March 28, 2024: Journal of Immunotherapy
https://read.qxmd.com/read/38545824/effect-of-galectin-1-on-prognosis-and-responsiveness-of-immune-checkpoint-plus-tyrosine-kinase-inhibition-in-renal-cell-carcinoma
#8
JOURNAL ARTICLE
Jiajun Wang, Sihong Zhang, Ying Wang, Yanjun Zhu, Xianglai Xu, Jianming Guo
BACKGROUND: In renal cell carcinoma (RCC), no clinically available biomarker has been utilized for checkpoint inhibitor immunotherapy (IO) + tyrosine kinase inhibitor (TKI) combinations. Galectin-1 overexpression is found in tumors, with potential immune-regulating roles. METHODS: RNA-sequencing was performed in two cohorts of RCC treated with IO/TKI combination therapy (ZS-MRCC, JAVELIN-101). Immunohistochemistry and flow cytometry were performed to investigate immune cell infiltration and function in the tumor microenvironment of RCC...
April 2024: Cancer Medicine
https://read.qxmd.com/read/38545758/tigit-blockade-reshapes-the-tumor-microenvironment-based-on-the-single-cell-rna-sequencing-analysis
#9
JOURNAL ARTICLE
Yanyan Lang, Hao Huang, Hongwei Jiang, Shaoxian Wu, Yaping Chen, Bin Xu, Yingting Liu, Dawei Zhu, Xiao Zheng, Lujun Chen, Jingting Jiang
Immune checkpoint blockade therapy is a pivotal approach in treating malignant tumors. TIGIT has emerged as a focal point of interest among the diverse targets for tumor immunotherapy. Nonetheless, there is still a lack of comprehensive understanding regarding the immune microenvironment alterations following TIGIT blockade treatment. To bridge this knowledge gap, we performed single-cell sequencing on mice both before and after the administration of anti-TIGIT therapy. Our analysis revealed that TIGIT was predominantly expressed on T cells and natural killer (NK) cells...
March 28, 2024: Journal of Immunotherapy
https://read.qxmd.com/read/38545680/inference-of-developmental-hierarchy-and-functional-states-of-exhausted-t-cells-from-epigenetic-profiles-with-deep-learning
#10
JOURNAL ARTICLE
Hongyan Chen, Dongxue Yan, Jie Sun, Meng Zhou
Exhausted T cells are a key component of immune cells that play a crucial role in the immune response against cancer and influence the efficacy of immunotherapy. Accurate assessment and measurement of T-cell exhaustion (TEX) are critical for understanding the heterogeneity of TEX in the tumor microenvironment (TME) and tailoring individualized immunotherapeutic strategies. In this study, we introduced DeepEpiTEX, a novel computational framework based on deep neural networks, for inferring the developmental hierarchy and functional states of exhausted T cells in the TME from epigenetic profiles...
March 28, 2024: Journal of Chemical Information and Modeling
https://read.qxmd.com/read/38545600/multi-omics-analysis-reveals-the-unique-landscape-of-dld-in-the-breast-cancer-tumor-microenvironment-and-its-implications-for-immune-related-prognosis
#11
JOURNAL ARTICLE
Lijun Xu, Lei Yang, Dan Zhang, Yunxi Wu, Jiali Shan, Huixia Zhu, Zhengyi Lian, Guying He, Chongyu Wang, Qingqing Wang
BACKGROUND: Cuproptosis, i.e., copper-induced programmed cell death, has potential implications in cancer therapy. However, the impact of the cuproptosis-related gene (CRG) dihydrolipoyl dehydrogenase (DLD) on breast cancer (BC) prognosis remains underexplored. METHODS: We employed real-time quantitative PCR and multiplexed immunostaining techniques to quantify DLD expression in both BC and the adjacent non-cancerous tissues. Immunofluorescence analysis was employed to assess the influence of DLD on immune cells and immunological checkpoints in the BC microenvironment...
December 2024: Computational and Structural Biotechnology Journal
https://read.qxmd.com/read/38545481/predictors-of-immunotherapy-efficacy-in-metastatic-non-small-cell-lung-cancer-lung-immune-prognostic-index-and-immune-related-toxicity
#12
JOURNAL ARTICLE
Alba Moratiel Pellitero, Maria Zapata Garcia, Marta Gascon Ruiz, Jose Miguel Arbones-Mainar, Rodrigo Lastra Del Prado, Dolores Isla
BACKGROUND: Immune checkpoint inhibitors (ICIs) have been proposed as the standard first-line and subsequent treatment for metastatic non-small cell lung cancer (NSCLC). This study analyzed whether patients with good lung immune prognostic index (LIPI) have a better response to ICIs and the relationship between immune-related adverse events (irAEs) and response in clinical practice. METHODS: This was an observational, retrospective, single-center study. Patients with stage IV NSCLC between 2016 and 2021 were included in the study...
April 2024: World Journal of Oncology
https://read.qxmd.com/read/38545192/predicting-mechanism-of-immune-response-in-microsatellite-instability-colorectal-cancer
#13
JOURNAL ARTICLE
Peng Sun, Yusong Luan, Xuhao Cai, Qi Liu, Peide Ren, Pengpan Xin, Yonggang Yu, Bolun Song, Yangyang Wang, Huijing Chang, Haoyue Ma, Yinggang Chen
Colorectal cancer (CRC), also known as colon cancer, is the third most common cancer and the fourth most cause of cancer-related death in the world. CRC can be classified into two major subtypes, including microsatellite instability (MSI) and microsatellite stability (MSS), which showed different characteristics in immunotherapy. Low sensitivity of diagnostic biomarkers and metastasis are still the principal cause of mortality, especially in MSI. Here, applying computational programs, we identified recurring expression programs based on single cell RNA sequencing (scRNA-Seq) data of CRC cell lines...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38545147/activation-of-astrocytes-by-anxa2-derived-extracellular-vesicles-from-lung-cancer-cells-affects-aggressiveness-immunotherapy-response-and-microenvironment-of-lung-cancer
#14
JOURNAL ARTICLE
Mudan He, Guogang Xie, Fang Shen, Xingjing Li
BACKGROUND: ANXA2 has been extensively documented in relation to cancer. Nevertheless, the involvement of ANXA2 in lung carcinoma remains uncertain. METHODS: Data from The Cancer Genome Atlas (TCGA) database was downloaded using open-access methods. The examination of publicly available data was conducted utilizing the R software. The mRNA level of specific molecules was detected using Real-time Quantitative PCR (qPCR). The protein level of specific molecules was detected using the Western blot assay...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38545126/crispr-car-t-and-nk-current-applications-and-future-perspectives
#15
REVIEW
Mohadeseh Khoshandam, Hossein Soltaninejad, Amir Ali Hamidieh, Saman Hosseinkhani
Chimeric antigen receptor T (CAR-T) cell therapy represents a breakthrough in personalized cancer treatments. In this regard, synthetic receptors comprised of antigen recognition domains, signaling, and stimulatory domains are used to reprogram T-cells to target tum or cells and destroy them. Despite the success of this approach in refractory B-cell malignancies, the optimal potency of CAR T-cell therapy for many other cancers, particularly solid tumors, has not been validated. Natural killer cells are powerful cytotoxic lymphocytes specialized in recognizing and dispensing the tumor cells in coordination with other anti-tumor immunity cells...
July 2024: Genes & Diseases
https://read.qxmd.com/read/38545115/therapeutic-approaches-to-enhance-natural-killer-cell-cytotoxicity
#16
REVIEW
Terran D Stenger, Jeffrey S Miller
Enhancing the cytotoxicity of natural killer (NK) cells has emerged as a promising strategy in cancer immunotherapy, due to their pivotal role in immune surveillance and tumor clearance. This literature review provides a comprehensive overview of therapeutic approaches designed to augment NK cell cytotoxicity. We analyze a wide range of strategies, including cytokine-based treatment, monoclonal antibodies, and NK cell engagers, and discuss criteria that must be considered when selecting an NK cell product to combine with these strategies...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38545114/overcoming-cold-tumors-a-combination-strategy-of-immune-checkpoint-inhibitors
#17
REVIEW
Peng Ouyang, Lijuan Wang, Jianlong Wu, Yao Tian, Caiyun Chen, Dengsheng Li, Zengxi Yao, Ruichang Chen, Guoan Xiang, Jin Gong, Zhen Bao
Immune Checkpoint Inhibitors (ICIs) therapy has advanced significantly in treating malignant tumors, though most 'cold' tumors show no response. This resistance mainly arises from the varied immune evasion mechanisms. Hence, understanding the transformation from 'cold' to 'hot' tumors is essential in developing effective cancer treatments. Furthermore, tumor immune profiling is critical, requiring a range of diagnostic techniques and biomarkers for evaluation. The success of immunotherapy relies on T cells' ability to recognize and eliminate tumor cells...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38545103/host-functionalization-of-macrin-nanoparticles-to-enable-drug-loading-and-control-tumor-associated-macrophage-phenotype
#18
JOURNAL ARTICLE
Biplab Sarkar, Sean P Arlauckas, Michael F Cuccarese, Christopher S Garris, Ralph Weissleder, Christopher B Rodell
Macrophages are critical regulators of the tumor microenvironment and often present an immuno-suppressive phenotype, supporting tumor growth and immune evasion. Promoting a robust pro-inflammatory macrophage phenotype has emerged as a therapeutic modality that supports tumor clearance, including through synergy with immune checkpoint therapies. Polyglucose nanoparticles (macrins), which possess high macrophage affinity, are useful vehicles for delivering drugs to macrophages, potentially altering their phenotype...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38545100/mucosal-associated-invariant-t-cells-in-cancer-dual-roles-complex-interactions-and-therapeutic-potential
#19
REVIEW
Mesut Yigit, Omer Faruk Basoglu, Derya Unutmaz
Mucosal-associated invariant T (MAIT) cells play diverse roles in cancer, infectious diseases, and immunotherapy. This review explores their intricate involvement in cancer, from early detection to their dual functions in promoting inflammation and mediating anti-tumor responses. Within the solid tumor microenvironment (TME), MAIT cells can acquire an 'exhausted' state and secrete tumor-promoting cytokines. On the other hand, MAIT cells are highly cytotoxic, and there is evidence that they may have an anti-tumor immune response...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38544737/nanomaterials-modulate-tumor-associated-macrophages-for-the-treatment-of-digestive-system-tumors
#20
REVIEW
Hao Li, Shuai Wang, Zhengqiang Yang, Xianwei Meng, Meng Niu
The treatment of digestive system tumors presents challenges, particularly in immunotherapy, owing to the advanced immune tolerance of the digestive system. Nanomaterials have emerged as a promising approach for addressing these challenges. They provide targeted drug delivery, enhanced permeability, high bioavailability, and low toxicity. Additionally, nanomaterials target immunosuppressive cells and reshape the tumor immune microenvironment (TIME). Among the various cells in the TIME, tumor-associated macrophages (TAMs) are the most abundant and play a crucial role in tumor progression...
June 2024: Bioactive Materials
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