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https://www.readbyqxmd.com/read/29049339/reliability-of-transcardiopulmonary-thermodilution-cardiac-output-measurement-in-experimental-aortic-valve-insufficiency
#1
Martin Petzoldt, Constantin J Trepte, Jan Ridder, Stefan Maisch, Philipp Klapsing, Jan F Kersten, Hans Peter Richter, Jens C Kubitz, Daniel A Reuter, Matthias S Goepfert
BACKGROUND: Monitoring cardiac output (CO) is important to optimize hemodynamic function in critically ill patients. The prevalence of aortic valve insufficiency (AI) is rising in the aging population. However, reliability of CO monitoring techniques in AI is unknown. The aim of this study was to investigate the impact of AI on accuracy, precision, and trending ability of transcardiopulmonary thermodilution-derived COTCPTD in comparison with pulmonary artery catheter thermodilution COPAC...
2017: PloS One
https://www.readbyqxmd.com/read/29048452/development-of-the-laboratory-prototype-cavypool-for-assessing-treatments-and-materials-for-swimming-pools
#2
F Valeriani, G Gianfranceschi, M Vitali, C Protano, V Romano Spica
BACKGROUND: Hygiene and surveillance in swimming pools are established by WHO Guidelines and national laws. Progress in water management and pool construction is revolutionizing the field, introducing new materials, systems, disinfection procedures or monitoring markers. Innovation advances challenge the upgrading of safety and quality in pools and the appropriate implementation of guidelines. STUDY DESIGN: In order to provide a device for laboratory test, a prototype was realized and applied to study and compare swimming pool materials and treatments...
November 2017: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/29048359/chitosan-ascorbate-nanoparticles-for-the-vaginal-delivery-of-antibiotic-drugs-in-atrophic-vaginitis
#3
Silvia Rossi, Barbara Vigani, Antonella Puccio, Maria Cristina Bonferoni, Giuseppina Sandri, Franca Ferrari
The aim of the present work was the development of chitosan ascorbate nanoparticles (CSA NPs) loaded into a fast-dissolving matrix for the delivery of antibiotic drugs in the treatment of atrophic vaginitis. CSA NPs loaded with amoxicillin trihydrate (AX) were obtained by ionotropic gelation in the presence of pentasodium tripolyphosphate (TPP). Different CSA:TPP and CSA:AX weight ratios were considered and their influence on the particle size, polydispersion index and production yield were investigated. CSA NPs were characterized for mucoadhesive, wound healing and antimicrobial properties...
October 19, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29047684/development-of-a-compact-underwater-laser-induced-breakdown-spectroscopy-libs-system-and-preliminary-results-in-sea-trials
#4
Jinjia Guo, Yuan Lu, Kai Cheng, Jiaojian Song, Wangquan Ye, Nan Li, Ronger Zheng
The exploitation and research of deep-sea hydrothermal vent has been an issue of great interest in ocean research in recent years. Laser-induced breakdown spectroscopy (LIBS) has great potential for ocean application due to the capabilities of stand-off, multiphase, and multielement analysis. In this work, a newly developed compact 4000 m rated LIBS system (LIBSea) is introduced with preliminary results of sea trials. The underwater system consists of an Nd:YAG single-pulsed laser operating at 1064 nm, an optical fiber spectrometer, an optics module, and an electronic controller module...
October 10, 2017: Applied Optics
https://www.readbyqxmd.com/read/29046768/smartphones-and-e-tablets-in-perioperative-medicine
#5
REVIEW
Frederic Michard
Smartphones and electronic tablets (e-tablets) have become ubiquitous devices. Their ease of use, smartness, accessibility, mobility and connectivity create unique opportunities to improve quality of surgical care from prehabilitation to rehabilitation. Before surgery, digital applications (Apps), serious games and text messaging may help for a better control of risk factors (hypertension, overweight), for smoking cessation, and for optimizing adherence to preoperative recommendations (e.g., regarding anticoagulation or antihypertensive treatments)...
October 2017: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/29045351/awareness-and-implementation-of-the-2014%C3%A2-espghan-naspghan-guideline-for-childhood-functional-constipation
#6
Ilan J N Koppen, M H Vriesman, M M Tabbers, C Di Lorenzo, M A Benninga
OBJECTIVE: To assess if physicians approach children with functional constipation according to the 2014 ESPGHAN/NASPGHAN guideline. METHODS: We invited pediatricians and pediatric gastroenterologists in the Netherlands and the U.S. to participate in this anonymous survey using a self-developed questionnaire containing 19 multiple-choice questions concerning evaluation and treatment of children with constipation. RESULTS: We included 328 physicians (67% from the U...
October 17, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29044493/combining-echo-and-natriuretic-peptides-to-guide-heart-failure-care-in-the-outpatient-setting-a-position-paper
#7
REVIEW
Frank Lloyd Dini, Erberto Carluccio, Fabrizio Montecucco, Gian Marco Rosa, Paolo Fontanive
BACKGROUND: Chronic heart failure (HF) is a relevant and growing public health problem. Although the prognosis has recently improved, it remains a lethal disease, with a mortality that equals or exceeds that of many malignancies. Furthermore, chronic HF is costly, representing a large and growing drain on healthcare resources. METHODS: This narrative review is based on the material searched for and obtained via PubMed up to May 2017. The search terms we used were: "heart failure, echocardiography, natriuretic peptides" in combination with "treatment, biomarkers, guidelines"...
October 16, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29042700/preoperative-risk-factors-for-conversion-of-laparoscopic-cholecystectomy-to-open-cholecystectomy-and-the-usefulness-of-the-2013-tokyo-guidelines
#8
Masashi Utsumi, Hideki Aoki, Tomoyoshi Kunitomo, Yutaka Mushiake, Isao Yasuhara, Fumitaka Taniguchi, Takashi Arata, Koh Katsuda, Kohji Tanakaya, Hitoshi Takeuchi
To identify predictive factors for conversion from laparoscopic cholecystectomy (LC) to open cholecystectomy performed for mixed indications as an acute or elective procedure. We retrospectively analyzed the data of 236 consecutive cases of LC performed in our department between January 2012 and January 2015, and evaluated preoperative risk factors for conversion and the usefulness of the 2013 Tokyo guidelines (TG2013) for diagnosing acute cholecystitis. The conversion rate in our series was 8% (19/236 cases)...
October 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/29041578/fluid-jet-array-parallel-machining-of-optical-microstructure-array-surfaces
#9
Chunjin Wang, Chi Fai Cheung, Mingyu Liu, Wing Bun Lee
Optical microstructure array surfaces such as micro-lens array surface, micro-groove array surface etc., are being used in more and more optical products, depending on its ability to produce a unique or particular performance. The geometrical complexity of the optical microstructures array surfaces makes them difficult to be fabricated. In this paper, a novel method named fluid jet-array parallel machining (FJAPM) is proposed to provide a new way to generate the microstructure array surfaces with high productivity...
September 18, 2017: Optics Express
https://www.readbyqxmd.com/read/29038612/dna-methylation-as-a-noninvasive-epigenetic-biomarker-for-the-detection-of-cancer
#10
REVIEW
Catherine Leygo, Marissa Williams, Hong Chuan Jin, Michael W Y Chan, Wai Kit Chu, Michael Grusch, Yuen Yee Cheng
In light of the high incidence and mortality rates of cancer, early and accurate diagnosis is an important priority for assigning optimal treatment for each individual with suspected illness. Biomarkers are crucial in the screening of patients with a high risk of developing cancer, diagnosing patients with suspicious tumours at the earliest possible stage, establishing an accurate prognosis, and predicting and monitoring the response to specific therapies. Epigenetic alterations are innovative biomarkers for cancer, due to their stability, frequency, and noninvasive accessibility in bodily fluids...
2017: Disease Markers
https://www.readbyqxmd.com/read/29038277/dilution-factor-of-quantitative-bacterial-cultures-obtained-by-bronchoalveolar-lavage-in-patients-with-ventilator-associated-bacterial-pneumonia-implications-for-optimal-antimicrobial-therapy-ventilator-associated-bacterial-pneumonia-study-group
#11
George L Drusano, Michael L Corrado, Gino Girardi, Evelyn J Ellis-Grosse, Richard G Wunderink, Helen Donnelly, Kenneth V Leeper, Mona Brown, Tasnova Malek, Robert Duncan Hite, Michelle Ferrari, Danijela Djureinovic, Marin H Kollef, Lisa Mayfield, Ann Doyle, Jean Chastre, Alain Combes, Thomas J Walsh, Krisztina Dorizas, Hassan Alnuaimat, Brooks Edward Morgan, Jordi Rello, Cristopher Alan Mazo Torre, Ronald N Jones, Robert K Flamm, Leah Woosley, Paul G Ambrose, Sujata Bhavnani, Christopher M Rubino, Catharine C Bulik, Arnold Louie, Michael Vicchiarelli, Colleen Berman
Ventilator-Associated Bacterial Pneumonia (VABP) is a difficult therapeutic problem. Considerable controversy exists regarding the optimal chemotherapy for this entity. The recent IDSA/ATS guidelines recommended a 7-day therapeutic course for VABP based on the balance of no negative impact on all-cause mortality, less resistance emergence and fewer antibiotic days counterbalanced with a higher relapse rate for patients whose pathogen is a non-fermenter. The bacterial burden causing an infection will have a substantial impact on treatment outcome and resistance selection...
October 16, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29036852/rehabilitation-modality-and-onset-differentially-influence-whisker-sensory-hypersensitivity-after-diffuse-traumatic-brain-injury-in-the-rat
#12
Theresa Currier Thomas, Ellen Magee Stockhausen, L Matthew Law, Aida Khodadad, Jonathan Lifshitz
BACKGROUND: As rehabilitation strategies advance as therapeutic interventions, the modality and onset of rehabilitation after traumatic brain injury (TBI) are critical to optimize treatment. Our laboratory has detected and characterized a late-onset, long-lasting sensory hypersensitivity to whisker stimulation in diffuse brain-injured rats; a deficit that is comparable to visual or auditory sensory hypersensitivity in humans with an acquired brain injury. OBJECTIVE: We hypothesize that the modality and onset of rehabilitation therapies will differentially influence sensory hypersensitivity in response to the Whisker Nuisance Task (WNT) as well as WNT-induced corticosterone (CORT) stress response in diffuse brain-injured rats and shams...
October 9, 2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/29036747/prevention-of-multidrug-resistant-infections-from-contaminated-duodenoscopes-position-statement-of-the-european-society-of-gastrointestinal-endoscopy-esge-and-european-society-of-gastroenterology-nurses-and-associates-esgena
#13
Ulrike Beilenhoff, Holger Biering, Reinhard Blum, Jadranka Brljak, Monica Cimbro, Jean-Marc Dumonceau, Cesare Hassan, Michael Jung, Christiane Neumann, Michael Pietsch, Lionel Pineau, Thierry Ponchon, Stanislav Rejchrt, Jean-François Rey, Verona Schmidt, Jayne Tillett, Jeanin van Hooft
Patients should be informed about the benefits and risks of endoscopic retrograde cholangiopancreatography (ERCP)Only specially trained and competent personnel should carry out endoscope reprocessing.Manufacturers of duodenoscopes should provide detailed instructions on how to use and reprocess their equipment.In the case of modifications to their equipment, manufacturers should provide updated instructions for use.Detailed reprocessing protocols based on the manufacturer's instructions for use should clearly lay out the different reprocessing steps necessary for each endoscope model...
October 16, 2017: Endoscopy
https://www.readbyqxmd.com/read/29035765/a-force-based-mechanistic-model-for-describing-activated-sludge-settling-process
#14
Guihua Xu, Fengjun Yin, Yuanjian Xu, Han-Qing Yu
Sludge settling as the last step in the biological wastewater treatment process substantially affects the system performance, and thus the design and control optimization of the sludge settling process has been frequently investigated with mathematical modeling tools. So far, these models are developed on the basis of the solid flux theory with numerous parameters and complicated boundary conditions, and their prediction results are often unsatisfactory. In this work, a new force-based mechanical model with five parameters was developed, in which five forces were adopted and Newton's law, rather than the flux theory, was used to describe the sludge settling process...
October 10, 2017: Water Research
https://www.readbyqxmd.com/read/29035463/effect-of-balanced-crystalloid-gelatin-and-hydroxyethyl-starch-on-coagulation-detected-by-rotational-thromboelastometry-in-vitro
#15
Silvie Sevcikova, Tomas Vymazal, Miroslav Durila
BACKGROUND: Fluid resuscitation with crystalloid and colloid solutions is a common treatment in perioperative medicine. However, a variety of unbalanced or balanced solutions are used in clinical practice and there is still vivid debate going on regarding selection of optimal fluid with minimal negative effect on coagulation to minimize bleeding and blood transfusion requirements. The aim of the study was to investigate adverse effects of balanced crystalloids and colloids on coagulation measured by thromboelastometry in vitro...
October 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29031956/the-solubility-permeability-trade-off-of-progesterone-with-cyclodextrins-under-physiological-conditions-experimental-observations-and-computer-simulations
#16
Le Sun, Bing Zhang, Jin Sun
This study intended to evaluate the effect of cyclodextrins on the apparent solubility and permeability of lipophilic drugs under physiological conditions and establish in silico model to choose the optimal amount of cyclodextrins for cyclodextrin-containing oral formulations. In order to study the effect of cyclodextrins under physiological conditions, bile salts and lecithin were added into the rat intestinal perfusion solution to simulate the fasted intestinal fluid. In addition, the in vivo oral absorption performances of cyclodextrin-containing formulations were simulated by gastrointestinal simulation technology based on the advanced compartmental absorption and transit model (ACAT)...
October 12, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29030805/an-explicit-structural-model-of-root-hair-and-soil-interactions-parameterised-by-synchrotron-x-ray-computed-tomography
#17
Samuel David Keyes, Konstantinos C Zygalakis, Tiina Roose
The rhizosphere is a zone of fundamental importance for understanding the dynamics of nutrient acquisition by plant roots. The canonical difficulty of experimentally investigating the rhizosphere led long ago to the adoption of mathematical models, the most sophisticated of which now incorporate explicit representations of root hairs and rhizosphere soil. Mathematical upscaling regimes, such as homogenisation, offer the possibility of incorporating into larger-scale models the important mechanistic processes occurring at the rhizosphere scale...
October 13, 2017: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/29030670/ultra-high-performance-supercritical-fluid-chromatography-with-quadrupole-time-of-flight-mass-spectrometry-uhpsfc-qtof-ms-for-analysis-of-lignin-derived-monomeric-compounds-in-processed-lignin-samples
#18
Jens Prothmann, Mingzhe Sun, Peter Spégel, Margareta Sandahl, Charlotta Turner
The conversion of lignin to potentially high-value low molecular weight compounds often results in complex mixtures of monomeric and oligomeric compounds. In this study, a method for the quantitative and qualitative analysis of 40 lignin-derived compounds using ultra-high-performance supercritical fluid chromatography coupled to quadrupole-time-of-flight mass spectrometry (UHPSFC/QTOF-MS) has been developed. Seven different columns were explored for maximum selectivity. Makeup solvent composition and ion source settings were optimised using a D-optimal design of experiment (DoE)...
October 13, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29028998/high-cryptococcal-antigen-titers-in-blood-are-predictive-of-subclinical-cryptococcal-meningitis-among-hiv-infected-patients
#19
Rachel M Wake, Erika Britz, Charlotte Sriruttan, Ivy Rukasha, Tanvier Omar, David C Spencer, Jeremy S Nel, Sello Mashamaite, Adeboye Adelekan, Tom M Chiller, Joseph N Jarvis, Thomas S Harrison, Nelesh P Govender
Background: High mortality rates among asymptomatic cryptococcal antigen (CrAg)-positive patients identified through CrAg screening, despite pre-emptive fluconazole, may be due to undiagnosed cryptococcal meningitis. Methods: Symptoms were reviewed in CrAg-positive patients identified through screening 19,233 individuals with CD4 cell counts < 100 cells/µL at 17 clinics and 3 hospitals in Johannesburg from September 2012 until September 2015, and 2 of these hospitals until June 2016...
October 5, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29028544/predicting-the-effect-of-relaxation-during-frequency-selective-adiabatic-pulses
#20
Annalise R Pfaff, Cailyn E McKee, Klaus Woelk
Adiabatic half and full passages are invaluable for achieving uniform, B1-insensitive excitation or inversion of macroscopic magnetization across a well-defined range of NMR frequencies. To accomplish narrow frequency ranges with adiabatic pulses (<100Hz), long pulse durations at low RF power levels are necessary, and relaxation during these pulses may no longer be negligible. A numerical, discrete recursive combination of the Bloch equations for longitudinal and transverse relaxation with the optimized equation for adiabatic angular motion of magnetization is used to calculate the trajectory of magnetization including its relaxation during adiabatic hyperbolic secant pulses...
October 3, 2017: Journal of Magnetic Resonance
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