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https://www.readbyqxmd.com/read/29471475/assessing-viral-transfer-during-doffing-of-ebola-level-personal-protective-equipment-in-a-biocontainment-unit
#1
Lisa M Casanova, Kimberly Erukunuakpor, Colleen S Kraft, Joel M Mumma, Francis T Durso, Ashley N Ferguson, Christina L Gipson, Victoria L Walsh, Craig Zimring, Jennifer DuBose, Jesse T Jacob
Background: Personal protective equipment (PPE) protects healthcare workers (HCWs) caring for patients with Ebola virus disease (EVD), and PPE doffing is a critical point for preventing viral self-contamination. We assessed contamination of skin, gloves, and scrubs after doffing Ebola-level PPE contaminated with surrogate viruses: bacteriophages MS2 and Φ6. Methods: In a medical biocontainment unit, HCWs (n = 10) experienced in EVD care donned and doffed PPE following unit protocols that incorporate trained observer guidance and alcohol-based hand rub (ABHR)...
February 17, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29470852/high-quality-human-and-rat-spermatozoal-rna-isolation-for-functional-genomic-studies
#2
E Bianchi, A Stermer, K Boekelheide, M Sigman, S J Hall, G Reyes, E Dere, K Hwang
Sperm RNA is a sensitive monitoring endpoint for male reproductive toxicants, and a potential biomarker to assess male infertility and sperm quality. However, isolation of sperm RNA is a challenging procedure due to the heterogeneous population of cells present in the ejaculate, the low yield of RNA per spermatozoon, and the absence of 18S and 28S ribosomal RNA subunits. The unique biology of spermatozoa has created some uncertainty in the field about RNA isolation methods, indicating the need for rigorous quality control checks to ensure reproducibility of data generated from sperm RNA...
February 22, 2018: Andrology
https://www.readbyqxmd.com/read/29470716/denosumab-a-potential-treatment-option-for-aneurysmal-bone-cyst-of-the-atlas
#3
REVIEW
Ravish Shammi Patel, Chetan Anil Dhamne, Anil Gopinathan, Nishant Kumar, Naresh Kumar
PURPOSE: Aneurysmal bone cysts (ABCs) of spine are conventionally treated with en-bloc resection or intralesional excision/curettage and reconstruction or filling of defects with bone cement. For the treatment of upper cervical ABCs, en-bloc resections are often not desirable considering the risk/benefit ratio while the risk of recurrence after intralesional excision is high. Hence, alternative management options are often necessary. We describe our clinical experience with one such treatment alternative-denosumab for the treatment of ABC of Atlas...
February 22, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29467276/neonatal-jaundice-improved-quality-and-cost-savings-after-implementation-of-a-standard-pathway
#4
Holly M Romero, Coral Ringer, Michael G Leu, Elaine Beardsley, Karen Kelly, Megan D Fesinmeyer, Wren L Haaland, James B Johnson, Darren Migita
OBJECTIVES: Seattle Children's Hospital sought to optimize the value equation for neonatal jaundice patients by creating a standard care pathway. METHODS: An evidence-based pathway for management of neonatal jaundice was created. This included multidisciplinary team assembly, comprehensive literature review, creation of a treatment algorithm and computer order sets, formulation of goals and metrics, roll-out of an education program for end users, and ongoing pathway improvement...
February 21, 2018: Pediatrics
https://www.readbyqxmd.com/read/29466869/patient-specific-ct-based-3d-passive-fsi-model-for-left-ventricle-in-hypertrophic-obstructive-cardiomyopathy
#5
Long Deng, Xueying Huang, Chun Yang, Yunhu Song, Dalin Tang
Left ventricular outflow tract obstruction is observed in 70% of patients with hypertrophic cardiomyopathy, which occurs in about 1 of every 500 adults in the general population. It has been widely believed that the motion of the mitral valve, in particular, its systolic anterior motion (SAM), attributes significantly to such obstruction. For a better understanding of the mitral valve motion, a 3D patient-specific fluid-structure interaction model of the left ventricle from a patient with hypertrophic obstructive cardiomyopathy based on computed tomography (CT) scan images was proposed in this study...
February 21, 2018: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/29466859/transferable-coarse-grained-models-of-liquid-liquid-equilibrium-using-local-density-potentials-optimized-with-the-relative-entropy
#6
Tanmoy Sanyal, M Scott Shell
Bottom-up coarse grained (CG) models are now regularly pursued to enable large length and time scale molecular simulations of complex, often macromolecular systems. However, predicting fluid phase equilibria using such models remain fundamentally challenging. A major problem stems from the typically low transferability of CG models beyond the densities and/or compositions at which they are parameterized, which is necessary if they are to describe distinct structural and thermodynamic properties unique to each phase...
February 21, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29465593/preoperative-fluid-management-in-traumatic-shock-a-retrospective-study-for-identifying-optimal-therapy-of-fluid-resuscitation-for-aged-patients
#7
Xiaoyu Lou, Guanzhen Lu, Mingming Zhao, Peiying Jin
Fluid resuscitation was used on aged patients with traumatic shock in their early postoperative recovery. The present study aimed to assess whether different fluid resuscitation strategies had an influence on aged patients with traumatic shock.A total of 219 patients with traumatic shock were recruited retrospectively. Lactated Ringer and hydroxyethyl starch solution were transfused for fluid resuscitation before definite hemorrhagic surgery. Subjects were divided into 3 groups: group A: 72 patients were given aggressive fluid infusion at 20 to 30 mL/min to restore normal mean arterial pressure (MAP) of 65 to 75 mm Hg...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29464511/computational-investigation-of-a-self-powered-fontan-circulation
#8
Marcus W Ni, Ray O Prather, Giovanna Rodriguez, Rachel Quinn, Eduardo Divo, Mark Fogel, Alain J Kassab, William M DeCampli
Children born with anatomic or functional "single ventricle" must progress through two or more major operations to sustain life. This management sequence culminates in the total cavopulmonary connection, or "Fontan" operation. A consequence of the "Fontan circulation", however, is elevated central venous pressure and inadequate ventricular preload, which contribute to continued morbidity. We propose a solution to these problems by increasing pulmonary blood flow using an "injection jet" (IJS) in which the source of blood flow and energy is the ventricle itself...
February 20, 2018: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/29464010/separation-of-cancer-cells-using-vortical-microfluidic-flows
#9
Hamed Haddadi, Hamed Naghsh-Nilchi, Dino Di Carlo
Label-free separation of viable cancer cells using vortical microfluidic flows has been introduced as a feasible cell collection method in oncological studies. Besides the clinical importance, the physics of particle interactions with the vortex that forms in a wall-confined geometry of a microchannel is a relatively new area of fluid dynamics. In our previous work [Haddadi and Di Carlo, J. Fluid. Mech. 811 , 436-467 (2017)], we have introduced distinct aspects of inertial flow of dilute suspensions over cavities in a microchannel such as breakdown of the separatrix and formation of stable limit cycle orbits for finite size polystyrene particles...
January 2018: Biomicrofluidics
https://www.readbyqxmd.com/read/29461392/combined-colloid-preload-and-crystalloid-coload-versus-crystalloid-coload-during-spinal-anesthesia-for-cesarean-delivery-a-randomized-controlled-trial
#10
Mohamed Mohamed Tawfik, Amany Ismail Tarbay, Ahmed Mohamed Elaidy, Karim Ali Awad, Hanaa Mohamed Ezz, Mohamed Ahmed Tolba
BACKGROUND: The optimal strategy of fluid administration during spinal anesthesia for cesarean delivery is still unclear. Ultrasonography of the inferior vena cava (IVC) has been recently used to assess the volume status and predict fluid responsiveness. In this double-blind, randomized controlled study, we compared maternal hemodynamics using a combination of 500-mL colloid preload and 500-mL crystalloid coload versus 1000-mL crystalloid coload. We assessed the IVC at baseline and at subsequent time points after spinal anesthesia...
February 14, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29460802/can-quantab-titrator-sticks-reliably-predict-urinary-sodium
#11
Fergus W Hamilton, Chris M Penfold, Andrew R Ness, Kirsty P Stevenson, Charlotte Atkinson, Andrew M Day, Gregory M Sebepos-Rogers, Jonathan Tyrrell-Price
BACKGROUND & AIMS: Urinary sodium concentration is a commonly used marker for extracellular fluid depletion which is often associated with dehydration. A point of care test for urinary sodium may reduce delays in clinical decision making by offering more timely guidance leading to improved salt and fluid management. We compared laboratory assessed urinary sodium with a potential point of care measure of urinary chloride in a variety of in- and outpatient specialities, to explore its use as an indicator of low urine sodium...
February 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29460180/solidification-of-hydatid-cyst-fluid-with-an-injectable-chitosan-carboxymethylcellulose-%C3%AE-glycerophosphate-hydrogel-for-effective-control-of-spillage-during-aspiration-of-hydatid-cysts
#12
Mostafa D A Azadi, Shadi Hassanjili, Khalil Zarrabi, Bahador Sarkari
Cystic echinococcosis (CE)/hydatid cyst is one of the most important helminthic diseases in the world. The treatment of hydatid cyst ranges from surgical intervention to chemotherapy, although the efficacy of chemotherapy is still unclear. Postoperative complication which results from the spillage of cysts during surgical operation is one of the most important concerns in surgical treatment of hydatid cyst. The aim of the current study was to solidify the hydatid cyst fluid (HCF) with an injectable and thermosensitive chitosan (CS)/carboxymethyl cellulose (CMC)/β-glycerol phosphate (BGP) hydrogel for effective control of spillage during the aspiration of hydatid cysts...
February 19, 2018: Progress in Biomaterials
https://www.readbyqxmd.com/read/29453718/cfd-simulation-of-copper-ii-extraction-with-tfa-in-non-dispersive-hollow-fiber-membrane-contactors
#13
Amir Muhammad, Mohammad Younas, Mashallah Rezakazemi
This study presents computational fluid dynamics (CFD) simulation of dispersion-free liquid-liquid extraction of copper(II) with trifluoroacetylacetone (TFA) in hollow fiber membrane contactor (HFMC). Mass and momentum balance Navier-Stokes equations were coupled to address the transport of copper(II) solute across membrane contactor. Model equations were simulated using COMSOL Multiphysics™. The simulation was run to study the detailed concentration distribution of copper(II) and to investigate the effects of various parameters like membrane characteristics, partition coefficient, and flow configuration on extraction efficiency...
January 27, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29452928/comprehensive-on-line-two-dimensional-liquid-chromatography-%C3%A3-supercritical-fluid-chromatography-with-trapping-column-assisted-modulation-for-depolymerised-lignin-analysis
#14
Mingzhe Sun, Margareta Sandahl, Charlotta Turner
Lignin depolymerisation produces a large variety of low molecular weight phenolic compounds that can be upgraded to value-added chemicals. Detailed analysis of these complex depolymerisation mixtures is, however, hampered by the lack of resolving power of traditional analysis techniques. In this study, a novel online comprehensive two-dimensional reversed-phase liquid chromatography (RPLC) × supercritical fluid chromatography (SFC) method with trapping column interface was developed for the separation of phenolic compounds in depolymerised lignin samples...
February 6, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29450610/ctc-technique-methods-to-ensure-an-optimal-exam
#15
Kevin J Chang, David H Kim
CT colonography (CTC) has demonstrated equivalent accuracy to optical colonoscopy in the detection of clinically relevant polyps and tumors but this is only possible when technique is optimized. The two most important features of a high-quality CTC are a well-prepared colon and a distended colon. This article will discuss the dietary, bowel preparation, and fecal/fluid tagging options to best prepare the colon. Strategies to optimally distend the colon will also be discussed. CT scan techniques including patient positioning and radiation dose optimization will be reviewed...
February 15, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29450473/elevated-blood-viscosity-and-micro-recirculation-linked-to-coronary-stent-malapposition
#16
Eric Poon, Vikas Thondapu, Umair Hayat, Peter Barlis, Chooi Yap, Po Kuo, Qisen Wang, Jiawei Ma, Shuang Zhu, Stephen Moore, Andrew Ooi
One particular complexity of coronary artery is the natural tapering of the vessel with proximal segments having larger caliber and distal tapering as the vessel get smaller. The natural tapering of a coronary artery often leads to proximal incomplete stent apposition (ISA). ISA alters coronary hemodynamics and creates pathological path to develop complications such as in-stent restenosis, and more worryingly, stent thrombosis. By employing state-of-the-art computer-aided design software, generic stent hoops were virtually deployed in an idealized tapered coronary artery with decreasing malapposition distance...
February 14, 2018: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29449487/wrapping-with-a-splash-high-speed-encapsulation-with-ultrathin-sheets
#17
Deepak Kumar, Joseph D Paulsen, Thomas P Russell, Narayanan Menon
Many complex fluids rely on surfactants to contain, protect, or isolate liquid drops in an immiscible continuous phase. Thin elastic sheets can wrap liquid drops in a spontaneous process driven by capillary forces. For encapsulation by sheets to be practically viable, a rapid, continuous, and scalable process is essential. We exploit the fast dynamics of droplet impact to achieve wrapping of oil droplets by ultrathin polymer films in a water phase. Despite the violence of splashing events, the process robustly yields wrappings that are optimally shaped to maximize the enclosed fluid volume and have near-perfect seams...
February 16, 2018: Science
https://www.readbyqxmd.com/read/29448225/a-dye-sensitized-solar-cell-acting-as-the-electrical-reading-box-of-an-immunosensor-application-to-cea-determination
#18
Liliana A A N A Truta, Felismina T C Moreira, M Goreti F Sales
Monitoring cancer biomarkers in biological fluids has become a key tool for disease diagnosis, which should be of easy access anywhere in the world. The possibility of reducing basic requirements in the field of electrochemical biosensing may open doors in this direction. This work proposes for this purpose an innovative electrochemical immunosensing system using a photovoltaic cell as an electrical reading box. Immunosensing ensures accuracy, the electrochemical-ground of the device ensures sensitivity and detectability, and the photovoltaic cell drives the system towards electrical autonomy...
February 7, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29446127/whole-body-mri-for-metastatic-cancer-detection-using-t-2-weighted-imaging-with-fat-and-fluid-suppression
#19
Xinzeng Wang, Ali Pirasteh, James Brugarolas, Neil M Rofsky, Robert E Lenkinski, Ivan Pedrosa, Ananth J Madhuranthakam
PURPOSE: To develop a whole-body MRI technique at 3T with improved lesion conspicuity for metastatic cancer detection using fast, high-resolution and high SNR T 2 -weighted (T 2 W) imaging with simultaneous fat and fluid suppression. THEORY AND METHODS: The proposed dual-echo T 2 -weighted acquisition for enhanced conspicuity of tumors (DETECT) acquires 4 images, in-phase (IP) and out-of-phase (OP) at a short and a long TE using single-shot turbo spin echo. The IP/OP images at the short and long TEs are reconstructed using the standard Dixon and shared-field-map Dixon reconstruction respectively, for robust fat-water separation...
February 14, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29445972/design-and-validation-of-an-osteochondral-bioreactor-for-the-screening-of-treatments-for-osteoarthritis
#20
Derek A Nichols, Inderbir S Sondh, Steven R Litte, Paolo Zunino, Riccardo Gottardi
Bioreactors are systems that can be used to monitor the response of tissues and cells to candidate drugs. Building on the experience developed in the creation of an osteochondral bioreactor, we have designed a new 3D printed system, which allows optical access to the cells throughout testing for in line monitoring. Because of the use of 3D printing, the fluidics could be developed in the third dimension, thus maintaining the footprint of a single well of a typical 96 well plate. This new design was optimized to achieve the maximum fluid transport through the central chamber, which corresponds to optimal nutrient or drug exposure...
February 14, 2018: Biomedical Microdevices
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