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https://www.readbyqxmd.com/read/29320537/correlation-of-a-new-index-reflecting-the-fluctuation-of-parasympathetic-tone-and-fetal-acidosis-in-an-experimental-study-in-a-sheep-model
#1
C Garabedian, Y Clermont-Hama, D Sharma, E Aubry, L Butruille, P Deruelle, L Storme, J De Jonckheere, V Houfflin-Debarge
The autonomic nervous system plays a leading role in the control of fetal homeostasis. Fetal heart rate variability (HRV) analysis is a reflection of its activity. We developed a new index (the Fetal Stress Index, FSI) reflecting parasympathetic tone. The objective of this study was to evaluate this index as a predictor of fetal acid-base status. This was an experimental study on chronically instrumented fetal lambs (n = 11, surgery at 128 +/- 2 days gestational age, term = 145 days). The model was based on 75% occlusion of the umbilical cord for a maximum of 120 minutes or until an arterial pH ≤ 7...
2018: PloS One
https://www.readbyqxmd.com/read/29311487/acyl-chain-preference-in-foam-cell-formation-from-mouse-peritoneal-macrophages
#2
Yuko Fujiwara, Kotaro Hama, Makoto Tsukahara, Ryosuke Izumi-Tsuzuki, Toru Nagai, Mihoko Ohe-Yamada, Keizo Inoue, Kazuaki Yokoyama
Macrophage foam cells play critical roles in the initiation and development of atherosclerosis by synthesizing and accumulating cholesteryl ester (CE) in lipid droplets. However, in analyzing lipid metabolism in foam cell formation, studies have focused on the sterol group, and little research has been done on the acyl chains. Therefore, we adapted a model system using liposomes containing particular acyl chains and examined the effect of various acyl chains on foam cell formation. Of the phosphatidylserine (PS) liposomes tested containing PS, phosphatidylcholine, and cholesterol, we found that unsaturated (C18:1), but not saturated (C16:0 and C18:0), PS liposomes induced lipid droplet formation, indicating that foam cell formation depends on the nature of the acyl chain of the PS liposomes...
2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29291516/high-growth-potential-and-nitrogen-removal-performance-of-marine-anammox-bacteria-in-shrimp-aquaculture-sediment
#3
Luong Van Duc, Bongkeun Song, Hiroaki Ito, Takehide Hama, Masashi Otani, Yasunori Kawagoshi
Anaerobic ammonium oxidation (anammox) bacteria were enriched in continuous packed-bed columns with marine sediment. One column (SB-C) was packed with only marine sediment collected from a shrimp-aquaculture pond, and another column (SB-AMX) was inoculated with marine anammox bacteria (MAB) as a control. These columns were continuously fed with natural or artificial seawater including ammonium (NH4+) and nitrite (NO2-). The SB-AMX showed anammox activities from the beginning and continued for over 200 days...
December 28, 2017: Chemosphere
https://www.readbyqxmd.com/read/29286556/total-synthesis-of-%C3%A2-phomoidride-d
#4
Joyce C Leung, Aaron A Bedermann, Jón T Njardarson, David A Spiegel, Graham K Murphy, Naoto Hama, Barry M Twenter, Ping Dong, Tatsuya Shirahata, Ivar M McDonald, Munenori Inoue, Nobuaki Taniguchi, Travis C McMahon, Christopher M Schneider, Nancy Tao, Brian M Stoltz, John Wood
Described herein is a synthetic strategy for the total synthesis of phomoidride D. This highly efficient and stereoselective approach provides rapid assembly of the carbocyclic core by way of a tandem phenolic oxidation/intramolecular Diels-Alder cycloaddition. A subsequent SmI2 mediated cyclization cascade delivers an isotwistane intermediate poised for a Wharton fragmentation that unveils the requisite bicyclo[4.3.1]decene skeleton and sets the stage for synthesis completion.
December 29, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29284804/anxiety-and-depression-in-irritable-bowel-syndrome
#5
Arko Banerjee, Sujit Sarkhel, Rajib Sarkar, Gopal Krishna Dhali
Background: Psychological factors have been prominently implicated in the causation as well as maintenance of irritable bowel syndrome (IBS). Studies comparing psychiatric morbidity in IBS with healthy controls have reported contrasting findings. The current study was undertaken to assess the prevalence of anxiety and depression in patients with IBS in comparison to healthy controls and to explore the relationship, if any, of anxiety and depression with various subtypes of IBS. Materials and Methods: Fifty consecutive patients of IBS (diagnosed as per Rome III criteria) between 18 and 65 years of age and fifty age- and sex-matched healthy controls were assessed for the presence of anxiety and depression using Hamilton Rating Scale for Anxiety (HAMA) and Hamilton Rating Scale for Depression (HAMD), respectively...
November 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29275582/-effect-analysis-on-deanxit-combined-with-shuganjieyu-capsule-in-the-treatment-of-refractory-gastroesophageal-reflux-disease
#6
X Y Yang, C Y Guo, X Zhang, Y Q Zhong, C Tian
Objective: To investigate the curative effect of Deanxit combined with Shuganjieyu capsule on the treatment of refractory gastroesophageal reflux disease. Methods: A total of 125 patients with refractory gastroesophageal reflux disease who had failed in standard lansolazole capsule treatment in the Department of Gastroenterology, First People's Hospital of Neijiang were selected. According to the symptom scores and mood scores of gastroesophageal reflux disease, patients were randomly and double-blindly divided into five groups...
November 28, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29233928/integrated-molecular-characterization-of-the-lethal-pediatric-cancer-pancreatoblastoma
#7
Tomoya Isobe, Masafumi Seki, Kenichi Yoshida, Masahiro Sekiguchi, Yusuke Shiozawa, Yuichi Shiraishi, Shunsuke Kimura, Misa Yoshida, Yoshikage Inoue, Akira Yokoyama, Nobuyuki Kakiuchi, Hiromichi Suzuki, Keisuke Kataoka, Yusuke Sato, Tomoko Kawai, Kenichi Chiba, Hiroko Tanaka, Teppei Shimamura, Motohiro Kato, Akihiro Iguchi, Asahito Hama, Tomoaki Taguchi, Masaharu Akiyama, Junya Fujimura, Akiko Inoue, Tsuyoshi Ito, Takao Deguchi, Chikako Kiyotani, Tomoko Iehara, Hajime Hosoi, Akira Oka, Masashi Sanada, Yukichi Tanaka, Kenichiro Hata, Satoru Miyano, Seishi Ogawa, Junko Takita
Pancreatoblastoma (PBL) is a rare pediatric pancreatic malignancy for which the molecular pathogenesis is not understood. In this study, we report the findings of an integrated multi-omics study of whole exome and RNA sequencing as well as genome-wide copy number and methylation analyses of 10 PBL cases. The PBL genome was characterized by a high frequency of aberrant activation of the Wnt signaling pathway, either via somatic mutations of CTNNB1 (90%) and copy-neutral loss of heterozygosity (CN-LOH) of APC (10%)...
December 12, 2017: Cancer Research
https://www.readbyqxmd.com/read/29231433/-transcutaneous-vagus-nerve-stimulation-for-primary-insomnia-and-affective-disorder-a-report-of-35-cases
#8
Man Luo, Xiaoxiao Qu, Shaoyuan Li, Jingjun Zhao, Yufeng Zhao, Yue Jiao, Peijing Rong
OBJECTIVE: To observe and evaluate the clinical efficacy of transcutaneous vagus nerve stimulation (taVNS) at auricular concha for primary insomnia (PI) and affective disorder. METHODS: A total of 35 patients who met the diagnosis standard of PI in Diagnostic and statistical manual of mental disorders (5th edition) were included. The self-developed auricular vagus nerve stimulator (TENS-200A) was applied at auricular concha, 30 min per treatment, twice a day, 5 days a week for consecutive 4 weeks...
March 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29214090/bone-resection-for-isolated-ulnar-head-fracture
#9
Hiromasa Akino, Shunpei Hama, Masataka Yasuda, Kenta Minato, Masahiro Miyashita
Distal ulnar fractures often occur with distal radius fractures (DRFs), and ulnar styloid fractures commonly occur in the setting of DRF. However, isolated ulnar head fractures are rare. We report a case of isolated ulnar head fracture in which we performed bone resection because the ulnar head bone fragment fractured when internal screw fixation was attempted. His outcome at 18 months postoperatively was considered excellent. However, we do not advocate bone resection other than failure of fixation and the difficult case to perform internal fixation...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/29208903/a-novel-bioreactor-system-for-biaxial-mechanical-loading-enhances-the-properties-of-tissue-engineered-human-cartilage
#10
Christoph Meinert, Karsten Schrobback, Dietmar W Hutmacher, Travis J Klein
The ex vivo engineering of autologous cartilage tissues has the potential to revolutionize the clinical management of joint disorders. Yet, high manufacturing costs and variable outcomes associated with tissue-engineered implants are still limiting their application. To improve clinical outcomes and facilitate a wider use of engineered tissues, automated bioreactor systems capable of enhancing and monitoring neotissues are required. Here, we developed an innovative system capable of applying precise uni- or biaxial mechanical stimulation to developing cartilage neotissues in a tightly controlled and automated fashion...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29188041/effect-of-processing-methods-on-the-nutritional-content-of-three-traditional-vegetables-leaves-amaranth-black-nightshade-and-jute-mallow
#11
Korotimi Traoré, Charles Parkouda, Aly Savadogo, Fatoumata Ba/Hama, Regine Kamga, Yves Traoré
The study assessed changes in nutritional content of some commonly consumed traditional vegetables subjected to postharvest processes. Amaranth (Amaranthus cruentus L.), black nightshade (Solanum scabrum Mill.) and jute mallow (Corchorus olitorius L.) leaves used as vegetables were subjected to blanching, boiling and drying. The proximate composition and β-carotene content of fresh and processed leaves were determined. Amaranth, black nightshade and jute mallow leaves had 25.21%, 39.74% and 29.18% of protein, respectively...
November 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/29187850/effect-of-roux-en-y-bariatric-surgery-on-lipoproteins-insulin-resistance-and-systemic-and-vascular-inflammation-in-obesity-and-diabetes
#12
Rahul Yadav, Salam Hama, Yifen Liu, Tarza Siahmansur, Jonathan Schofield, Akheel A Syed, Michael France, Philip Pemberton, Safwaan Adam, Jan Hoong Ho, Reza Aghamohammadzadeh, Shaishav Dhage, Rachelle Donn, Rayaz A Malik, John P New, Maria Jeziorska, Paul Durrington, Basil A Ammori, Handrean Soran
Purpose: Obesity is a major modifiable risk factor for cardiovascular disease. Bariatric surgery is considered to be the most effective treatment option for weight reduction in obese patients with and without type 2 diabetes (T2DM). Objective: To evaluate changes in lipoproteins, insulin resistance, mediators of systemic and vascular inflammation, and endothelial dysfunction following Roux-en-Y bariatric surgery in obese patients with and without diabetes. Materials and methods: Lipoproteins, insulin resistance, mediators of systemic and vascular inflammation, and endothelial dysfunction were measured in 37 obese patients with (n = 17) and without (n = 20) T2DM, before and 6 and 12 months after Roux-en-Y bariatric surgery...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29187220/genomic-copy-number-variation-analysis-in-multiple-system-atrophy
#13
Yuka Hama, Masataka Katsu, Ichigaku Takigawa, Ichiro Yabe, Masaaki Matsushima, Ikuko Takahashi, Takayuki Katayama, Jun Utsumi, Hidenao Sasaki
Genomic variation includes single-nucleotide variants, small insertions or deletions (indels), and copy number variants (CNVs). CNVs affect gene expression by altering the genome structure and transposable elements within a region. CNVs are greater than 1 kb in size; hence, CNVs can produce more variation than can individual single-nucleotide variations that are detected by next-generation sequencing. Multiple system atrophy (MSA) is an α-synucleinopathy adult-onset disorder. Pathologically, it is characterized by insoluble aggregation of filamentous α-synuclein in brain oligodendrocytes...
November 29, 2017: Molecular Brain
https://www.readbyqxmd.com/read/29185199/predictors-for-the-treatment-effect-of-sodium-glucose-co-transporter-2-inhibitors-in-patients-with-type-2-diabetes-mellitus
#14
Shusuke Yagi, Ken-Ichi Aihara, Takeshi Kondo, Kiyoe Kurahashi, Sumiko Yoshida, Itsuro Endo, Daiju Fukuda, Yutaka Nakaya, Kin-Ichiro Suwaki, Takashi Takeji, Toshihiro Wada, Hotimah Masdan Salim, Saori Hama, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Takeshi Tobiume, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Munehide Matsuhisa, Michio Shimabukuro, Masashi Akaike, Masataka Sata
INTRODUCTION: Predictors for the effect of sodium glucose co-transporter 2 (SGLT2) inhibitors at lowering hemoglobin A1c (HbA1c) levels in type 2 diabetes mellitus patients remain unclear. We therefore aimed to elucidate these predictors in type 2 diabetes patients after 3 months of SGLT2 treatment. METHODS: A total of 302 consecutive type 2 diabetes patients who had been treated with SGLT2 inhibitors as monotherapy or add-on therapy to existing antidiabetic treatments were enrolled retrospectively...
November 28, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/29181166/successful-and-long-term-response-to-trastuzumab-plus-paclitaxel-combination-therapy-in-human-epidermal-growth-factor-receptor-2-positive-extramammary-paget-s-disease-a-case-report-and-review-of-the-literature
#15
Takashi Ichiyama, Daisuke Gomi, Toshirou Fukushima, Takashi Kobayashi, Nodoka Sekiguchi, Akiyuki Sakamoto, Shigeru Sasaki, Keiko Mamiya, Tomonobu Koizumi, Yoshihisa Hama
A 58-year-old woman with a histologically confirmed diagnosis of vulvar extramammary Paget's disease (EMPD) was referred to our hospital due to locally advanced and relapsed EMPD. The patient had undergone surgical resection three times for relapsed vulvar EMPD over a period of 12 years, but developed locally advanced and unresectable EMPD. As pathological examination indicated that the lesion was positive for human epidermal growth factor receptor 2 (HER2) on immunohistochemical staining, the patient was treated with trastuzumab plus paclitaxel...
November 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29177570/genetic-risk-factors-for-chemotherapy-induced-nausea-and-vomiting-in-patients-with-cancer-receiving-cisplatin-based-chemotherapy
#16
Mari Yokoi, Daiki Tsuji, Kenichi Suzuki, Yohei Kawasaki, Masahiko Nakao, Hideaki Ayuhara, Yuuki Kogure, Kazuhiko Shibata, Toshinobu Hayashi, Keita Hirai, Kazuyuki Inoue, Toshihiro Hama, Koji Takeda, Makoto Nishio, Kunihiko Itoh
PURPOSE: Younger age and female sex have already been well-known risk factors for chemotherapy-induced nausea and vomiting (CINV), and 30-50% of cancer patients still suffer from CINV. Genetic polymorphisms are suggested to influence antiemetic treatment response. METHODS: This study included a subset of patients previously enrolled in a randomised controlled trial; 156 patients were evaluated. This study aimed to evaluate the role of pharmacogenomic polymorphisms relevant to antiemetic response in patients with cancer receiving cisplatin-based chemotherapy...
November 24, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29172108/how-lipase-technology-contributes-to-evolution-of-biodiesel-production-using-multiple-feedstocks
#17
REVIEW
Shinji Hama, Hideo Noda, Akihiko Kondo
Given the increasing interest in alternative processes for producing biodiesel, we focused on the latest screening of lipases and bioprocess design using multiple feedstocks. The implementation of lipase technology to the biodiesel industry is in the early stages. However, current research has made phenomenal advances in generating lipase variants and in engineering biodiesel production. The structural insights into lipase stability, together with primary screening, have opened up opportunities for acquiring lipase variants that are highly tolerant under industrially relevant conditions...
November 21, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/29169535/one-flag-two-rallies-mechanisms-of-public-opinion-in-israel-during-the-2014-gaza-war
#18
Yuval Feinstein
In Israel, public reaction to the 2014 Gaza war included massive support for the military operation and a sharp increase in the popularity of Prime Minister Netanyahu. To understand what caused these "rally-round-the-flag" (RRTF) effects, panel data were collected from a representative sample of the Jewish majority in Israel during and after the war. The article integrate empirical and theoretical arguments from public opinion studies, and from social and political psychology, to contextualize and guide the analysis...
January 2018: Social Science Research
https://www.readbyqxmd.com/read/29150713/efficacy-of-silexan-in-subthreshold-anxiety-meta-analysis-of-randomised-placebo-controlled-trials
#19
Hans-Jürgen Möller, Hans-Peter Volz, Angelika Dienel, Sandra Schläfke, Siegfried Kasper
Subthreshold psychiatric disorders do not fully meet the diagnostic criteria of syndromal disorders but may be associated with comparable disability. To investigate the anxiolytic effect of Silexan, an active substance from lavender oil for oral administration, in patients with subthreshold anxiety, a meta-analysis that included all published trials with Silexan in this indication was performed. Three randomised, placebo-controlled trials in subthreshold anxiety disorders (anxiety disorder not otherwise specified, restlessness and agitation, mixed anxiety and depressive disorder) were included...
November 17, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/29149884/predictors-of-early-onset-post-ischemic-stroke-depression-a-cross-sectional-study
#20
Guilin Meng, Xiaoye Ma, Lei Li, Yan Tan, Xiaohui Liu, Xueyuan Liu, Yanxin Zhao
BACKGROUND: Post-stroke depression (PSD) seriously affects the rehabilitation of nerve function and quality of life. However, the pathogenesis of PSD is still not clear. This study aimed to investigate the demographic, clinical, and biochemical factors in patients with PSD. METHODS: Patients with an acute ischemic stroke, who met the inclusion criteria at Shanghai Tenth People's Hospital from April 2016 to September 2016, were recruited for this study. The stroke severity was assessed using the National Institutes of Health Stroke Scale (NIHSS), and the mental state was assessed using Mini-Mental State Examination (MMSE), Hamilton Depression Scale (HAMD), and Hamilton Anxiety Scale (HAMA) at 1 week of admission...
November 17, 2017: BMC Neurology
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