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https://www.readbyqxmd.com/read/27902986/the-presence-of-hpv-dna-in-neck-lymph-node-metastasis-correlates-with-improved-overall-survival-of-patients-with-oropharyngeal-cancer-undergoing-surgical-treatment
#1
Eiji Shimura, Takanori Hama, Toshihito Suda, Masahiro Ikegami, Mitsuyoshi Urashima, Hiromi Kojima
BACKGROUND: Few studies have addressed how human papilloma virus (HPV) infection in oropharyngeal squamous cell carcinoma (OPSCC) affects the outcome of surgical therapy; furthermore, the relationship between the presence of HPV DNA and neck lymph node (LN) metastasis has not been well established. METHODS: A total of 65 patients who underwent surgery as a first-line therapy for OPSCC were enrolled in this study. In HPV-positive patients, the presence of HPV DNA in metastatic neck LN lesions was evaluated...
December 1, 2016: Oncology
https://www.readbyqxmd.com/read/27885829/autoclave-sterilization-of-pedot-pss-electrophysiology-devices
#2
Ilke Uguz, Mehran Ganji, Adel Hama, Atsunori Tanaka, Sahika Inal, Ahmed Youssef, Roisin M Owens, Pascale P Quilichini, Antoine Ghestem, Christophe Bernard, Shadi A Dayeh, George G Malliaras
Autoclaving, the most widely available sterilization method, is applied to poly(3,4-ethylenedioxythiophene) doped with polystyrene sulfonate (PEDOT:PSS) electrophysiology devices. The process does not harm morphology or electrical properties, while it effectively kills E. coli intentionally cultured on the devices. This finding paves the way to widespread introduction of PEDOT:PSS electrophysiology devices to the clinic.
November 25, 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27877903/the-novel-functional-nucleic-acid-ired-effectively-regulates-target-genes-following-cytoplasmic-delivery-by-faint-electric-treatment
#3
Mahadi Hasan, Noriko Tarashima, Koki Fujikawa, Takashi Ohgita, Susumu Hama, Tamotsu Tanaka, Hiroyuki Saito, Noriaki Minakawa, Kentaro Kogure
An intelligent shRNA expression device (iRed) contains the minimum essential components needed for shRNA production in cells, and could be a novel tool to regulate target genes. However, general delivery carriers consisting of cationic polymers/lipids could impede function of a newly generated shRNA via electrostatic interaction in the cytoplasm. Recently, we found that faint electric treatment (fET) of cells enhanced delivery of siRNA and functional nucleic acids into the cytoplasm in the absence of delivery carriers...
2016: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/27871835/development-of-flexible-nanocarriers-for-sirna-delivery-into-tumor-tissue
#4
Hyunkyung Jung, Yuri Shimatani, Mahadi Hasan, Kohei Uno, Susumu Hama, Kentaro Kogure
Various non-viral delivery systems for small interfering RNAs (siRNA) have been developed. Such delivery systems generally exhibit tightly formed spherical structures. While such carriers have demonstrated good transfection activity in mono-layered cell systems, effects against solid tumors are often less apparent and difficult to demonstrate, likely due to the rigid structures of the carriers, which may prevent penetration to deeper regions within tumor tissue. Herein, we developed a flexible nanocarrier (FNC) system that is able to penetrate to deeper regions within tumor tissue...
November 18, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27862617/anxiety-and-serum-catecholamines-as-predictors-of-survival-and-recurrence-in-hepatocellular-carcinoma
#5
Jinxia Liu, Guijuan Zong, Chengliang Zhang, Chunsun Li, Xudong Chen, Yixin Zhang
OBJECTIVE: Increasing evidence suggests that psychological factors are involved in tumor progression. This study investigated the influence of anxiety and serum catecholamines (CAs) on the prognosis of hepatocellular carcinoma (HCC). METHOD: We enrolled 110 HCC patients who underwent tumor resection at the Affiliated Hospital of Nantong University, China, in this long-term investigation between 2005 and 2009. We evaluated anxiety using the Hamilton Anxiety Rating Scale (HAMA) and analyzed CA levels using an ELISA kit...
November 8, 2016: Psycho-oncology
https://www.readbyqxmd.com/read/27861730/clinical-utility-of-next-generation-sequencing-based-minimal-residual-disease-in-paediatric-b-cell-acute-lymphoblastic-leukaemia
#6
Yuko Sekiya, Yinyan Xu, Hideki Muramatsu, Yusuke Okuno, Atsushi Narita, Kyogo Suzuki, Xinan Wang, Nozomu Kawashima, Hirotoshi Sakaguchi, Nao Yoshida, Asahito Hama, Yoshiyuki Takahashi, Koji Kato, Seiji Kojima
We assessed the clinical utility of next-generation sequencing (NGS)-based monitoring of minimal residual disease (MRD) in a uniformly treated cohort of 79 patients with paediatric B-cell acute lymphoblastic leukaemia. Bone marrow samples were collected at the time of diagnosis, days 33 and 80, pre- (4-5 months) and post- (24 months) maintenance therapy time points, and at relapse. We identified leukaemia-specific CDR3 sequences in 72 of 79 patients (91%) and detected MRD in 59 of 232 samples. Although MRD was detected in 28 of 55 samples (51%) on day 33, the frequencies of MRD detection decreased to 25% (16/65) at day 80, 19% (11/58) at 4-5 months and 7·4% (4/54) at 24 months...
November 11, 2016: British Journal of Haematology
https://www.readbyqxmd.com/read/27860394/simultaneous-conversion-of-free-fatty-acids-and-triglycerides-to-biodiesel-by-immobilized-aspergillus-oryzae-expressing-fusarium-heterosporum-lipase
#7
Jerome Amoah, Emmanuel Quayson, Shinji Hama, Ayumi Yoshida, Tomohisa Hasunuma, Chiaki Ogino, Akihiko Kondo
The presence of high levels of free fatty acids in oil is a barrier to one-step biodiesel production. Undesirable soaps are formed during conventional chemical methods, and enzyme deactivation occurs when enzymatic methods are used. This work investigates an efficient technique to simultaneously convert a mixture of free fatty acids and triglycerides. A partial soybean hydrolysate containing 73.04% free fatty acids and 24.81% triglycerides was used as a substrate for the enzymatic production of fatty acid methyl ester (FAME)...
November 17, 2016: Biotechnology Journal
https://www.readbyqxmd.com/read/27852375/-study-of-functional-connectivity-density-mapping-in-patients-with-acute-stress-response-by-using-resting-state-functional-mri-after-traffic-accident
#8
Y F Weng, R F Qi, X D Zhang, L Zhang, J Ke, Y Zhong, F Chen, Q Xu, G M Lu
Objective: To explore the changes of brain activity in traffic accident survivors with acute stress response within a week by using functional connectivity density (FCD) method. Method: A total of 20 traffic accidents survivors with acute stress disorders (acute stress disorder interview >3) and twenty healthy controls from Nanjing Jinling Hospital underwent the 3.0 T resting-state functional magnetic resonance imaging scan from January 2013 to February 2016. Functional connectivity density mapping was used to compare the brain functional connective networks between acute stress response survivors and controls...
November 8, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27832309/production-of-optically-pure-d-lactic-acid-from-brown-rice-using-metabolically-engineered-lactobacillus-plantarum
#9
Kenji Okano, Shinji Hama, Maki Kihara, Hideo Noda, Tsutomu Tanaka, Akihiko Kondo
Simultaneous saccharification and fermentation (SSF) of D-lactic acid was performed using brown rice as both a substrate and a nutrient source. An engineered Lactobacillus plantarum NCIMB 8826 strain, in which the ʟ-lactate dehydrogenase gene was disrupted, produced 97.7 g/L D-lactic acid from 20% (w/v) brown rice without any nutrient supplementation. However, a significant amount of glucose remained unconsumed and the yield of lactic acid was as low as 0.75 (g/g-glucose contained in brown rice). Interestingly, the glucose consumption was significantly improved by adapting L...
November 10, 2016: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27823833/prevalence-and-risk-factors-for-visual-hallucinations-in-chinese-patients-with-parkinson-s-disease
#10
Jun Zhu, Bo Shen, Liyu Lu, Wenya Lan, Yang Pan, Lili Zhang, Jingde Dong, Min Wang, Li Zhang
BACKGROUND AND PURPOSE: Parkinson's disease (PD) patients frequently present visual hallucinations (VHs)·The determinants of VHs in Chinese PD patients remain largely unknown. The aim of this study was to illuminate the prevalence and clinical correlates of VHs in the Chinese population with PD. METHODS: A total of 371 consecutive, idiopathic PD patients were recruited into the study. Patients were categorized as hallucinators and nonhallucinators according to Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS)...
October 27, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27818143/an-autophagic-flux-probe-that-releases-an-internal-control
#11
Takeshi Kaizuka, Hideaki Morishita, Yutaro Hama, Satoshi Tsukamoto, Takahide Matsui, Yuichiro Toyota, Akihiko Kodama, Tomoaki Ishihara, Tohru Mizushima, Noboru Mizushima
Macroautophagy is an intracellular degradation system that utilizes the autophagosome to deliver cytoplasmic components to the lysosome. Measuring autophagic activity is critically important but remains complicated and challenging. Here, we have developed GFP-LC3-RFP-LC3ΔG, a fluorescent probe to evaluate autophagic flux. This probe is cleaved by endogenous ATG4 proteases into equimolar amounts of GFP-LC3 and RFP-LC3ΔG. GFP-LC3 is degraded by autophagy, while RFP-LC3ΔG remains in the cytosol, serving as an internal control...
November 17, 2016: Molecular Cell
https://www.readbyqxmd.com/read/27808465/long-term-outcomes-of-95-children-with-moderate-aplastic-anemia-treated-with-horse-antithymocyte-globulin-and-cyclosporine
#12
Eri Nishikawa, Hiroshi Yagasaki, Asahito Hama, Hiromasa Yabe, Akira Ohara, Yoshiyuki Kosaka, Kazuko Kudo, Ryoji Kobayashi, Shouichi Ohga, Akira Morimoto, Ken-Ichiro Watanabe, Nao Yoshida, Hideki Muramatsu, Yoshiyuki Takahashi, Seiji Kojima
BACKGROUND: Currently, the standard management of moderate aplastic anemia (MAA) has not been well described, although the superiority of the combination of antithymocyte globulin (ATG) and cyclosporine (CyA) over CyA alone has been demonstrated in terms of hematological responses and failure-free survival (FFS). PROCEDURE: We adopted this therapeutic strategy and treated 95 children with MAA who were enrolled in two consecutive prospective studies between October 1992 and August 2009...
November 3, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27801340/-the-impact-of-cigarette-cessation-intervention-on-mental-state-of-patients-with-coronary-heart-disease
#13
Z M Zhou, X H Xu, J Liang, B Hu, Y J Cheng, C Shi, Y J Zhou
Objective: This study was designed to observe the impact of cigarette cessation on anxiety and depression in patients with coronary heart disease (CHD). Methods: A total of 690 cigarette smoking patients with CHD identified by coronary angiography (CAG) were included and analyzed in the study.The mental state were scored with Hamilton anxiety (HAMA) and depression (HAMD) scale both on admission and at 6-month follow-up.The patients were divided into two groups based on the cigarette cessation.The score of mental state between the two groups were compared...
November 1, 2016: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/27786465/carboxylate-ion-availability-at-the-air-water-interface
#14
Shinichi Enami, Tomihide Fujii, Yosuke Sakamoto, Tetsuya Hama, Yoshizumi Kajii
Amphiphilic organic compounds at the air-water interface play key roles in the nucleation, growth and aging process of atmospheric aerosol. Surface-active species are expected to react preferentially with atmospheric oxidants, such as the OH-radical, at the air-water interface via specific mechanisms. Establishing the relative availability of the different amphiphilic species to gas-phase oxidants at the air-water interface under atmospherically relevant conditions is, however, challenging. Here we report the interfacial availability of atmospherically relevant carboxylate ions, Rn-COO- (n = 1-7) and n-, cyclo-, aromatic-R6-COO- at the air-water interface via a novel application of mass spectrometry of aqueous microjets...
October 27, 2016: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/27747246/depressive-and-anxiety-disorders-in-systemic-lupus-erythematosus-patients-without-major-neuropsychiatric-manifestations
#15
Ru Bai, Shuang Liu, Yueyin Zhao, Yuqi Cheng, Shu Li, Aiyun Lai, Zhongqi Xie, Xinyu Xu, Zhaoping Lu, Jian Xu
Depressive and anxiety disorders are frequently observed in patients with Systemic Lupus Erythematosus (SLE). However, the underlying mechanisms are still unknown. We conducted this survey to understand the prevalence of depression and anxiety in SLE patients without major neuropsychiatric manifestations (non-NPSLE) and to explore the relationship between emotional disorders, symptoms, autoantibodies, disease activity, and treatments in SLE. 176 SLE patients were included, and SLE disease activity index (SLEDAI), Hamilton Depression Rating Scale (HAMD), and Hamilton Anxiety Rating Scale (HAMA) were recorded to evaluate their disease activity and emotional status...
2016: Journal of Immunology Research
https://www.readbyqxmd.com/read/27746253/a-rare-case-of-isolated-lower-segment-transverse-sacral-fracture-in-a-12-year-old-female-child-and-its-management-by-fixation-with-k-wire-a-case-report
#16
Ismaeel Baba-Rasul, Hemin M Hama Ameen, Awder Khazendar, Seerwan O Hasan
BACKGROUND: Isolated lower segment sacral fracture is very rare. To the best of our knowledge, there is only one case report of S4 stable fracture that was treated conservatively. CASE DESCRIPTION: Here, we report a 12-year-old female child who sustained isolated S5 fracture with anterior displacement of S5 and coccyx on S4. The patient was initially provided with conservative management for one month and twenty-five days. On the failure of this treatment procedure, the patient was treated surgically by partial coccygectomy with S4-S5 fixation after reduction by two K-wires...
October 13, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27735031/relationship-between-levels-of-inflammatory-cytokines-in-the-peripheral-blood-and-the-severity-of-depression-and-anxiety-in-patients-with-parkinson-s-disease
#17
X-M Wang, Y-G Zhang, A-L Li, Z-H Long, D Wang, X-X Li, J-H Xia, S-Y Luo, Y-H Shan
OBJECTIVE: The present study aims to investigate the relationship between expression of inflammatory cytokines in the peripheral blood and the severity of depression and anxiety in patients with Parkinson's disease (PD). PATIENTS AND METHODS: Between January 2012 and December 2015, 62 PD patients admitted to our institution were included in the PD group, and 62 healthy subjects seeking health check-up at our institution during the same period of time were enrolled in the control group...
September 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27714465/iga-nephropathy-with-presentation-of-nephrotic-syndrome-at-onset-in-children
#18
Yuko Shima, Koichi Nakanishi, Masashi Sato, Taketsugu Hama, Hironobu Mukaiyama, Hiroko Togawa, Ryojiro Tanaka, Kandai Nozu, Mayumi Sako, Kazumoto Iijima, Hiroyuki Suzuki, Norishige Yoshikawa
BACKGROUND: Despite a low incidence, nephrotic syndrome (NS) can present with IgA nephropathy (IgAN). The clinical characteristics and long-term outcomes of pediatric patients with IgAN presenting with NS (NS-IgAN) at onset have not been fully elucidated. METHODS: We retrospectively analyzed 426 patients, and compared clinical and pathological (Oxford) findings between those with NS-IgAN and those with non-NS-IgAN. RESULTS: Among 426 patients, 30 (7...
October 6, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/27698536/synergistic-antioxidative-effect-of-astaxanthin-and-tocotrienol-by-co-encapsulated-in-liposomes
#19
Chihiro Kamezaki, Ami Nakashima, Asako Yamada, Sachiko Uenishi, Hiroshi Ishibashi, Natsumi Shibuya, Susumu Hama, Shinzo Hosoi, Eiji Yamashita, Kentaro Kogure
Astaxanthin and vitamin E are both effective antioxidants that are frequently used in cosmetics, as food additives, and in to prevent oxidative damage. A combination of astaxanthin and vitamin E would be expected to show an additive anntioxidative effect. In this study, liposomes co-encapsulating astaxanthin and the vitamin E derivatives α-tocopherol (α-T) or tocotrienols (T3) were prepared, and the antioxidative activity of these liposomes toward singlet oxygen and hydroxyl radical was evaluated in vitro...
September 2016: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/27689521/migration-of-an-intrauterine-device-to-the-left-inguinal-region-the-first-reported-case
#20
Ismaeel Aghaways, Saman Anwer Wahid, Rawa Hama Ghareeb Ali, Falah Sabir, Fahmi Hussein Kakamad
INTRODUCTION: A large number of complications are reported with the use of IUD. Migration to inguinal region has not been mentioned in literature. We report a rare case of migrated IUD to inguinal canal. CASE REPORT: A 25-year-old lady presented with a painfull mass in the left inguinal region. Diagnostic work up showed migrated IUD to inguinal region. Operation was done and the impacted IUD with surrounding granuloma was retrieved. DISCUSSION: When the string of the IUD is no longer visible at the external os of the cervix, radiological scan must be performed, this should begin with a sonographic examination and plain abdominal radiography may be used to localize the IUD...
September 23, 2016: International Journal of Surgery Case Reports
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