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https://www.readbyqxmd.com/read/28299626/efficacy-and-safety-of-escitalopram-in-treatment-of-severe-depression-in-chinese-population
#1
Tianmei Si, Gang Wang, Fude Yang, Yiru Fang, Maosheng Fang, Jijun Li, Jicheng Dong, Xinhua Shen, Jianmin Zhuo, Qing Rui, Jinan Wang, Hu Cuili
Severe depression accounts for one-third of depressed patients. Increasing severity of depression usually hinders patients from achieving remission. This study evaluated the efficacy and safety of escitalopram in acute-phase treatment of severe major depressive disorder (MDD). A total of 225 participants with severe MDD (Diagnostic and Statistical Manual of Mental Disorders, 4th Edition criteria), with a current depressive episode and Montgomery-Asberg Depression Rating Scale (MADRS) score of ≥30 were enrolled...
March 15, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28282218/immunotoxins-in-cancer-therapy-review-and-update
#2
Bahman Akbari, Safar Farajnia, Shiva Ahdi Khosroshahi, Fatemeh Safari, Mohammadreza Yousefi, Hassan Dariushnejad, Leila Rahbarnia
Immunotoxins are a novel class of cancer therapeutics that contains a cytotoxic agent fused to a targeting moiety. Various toxic agents from different sources are used in immunotoxin development, including bacterial, plant and human origin cytotoxic elements. Although bacterial and plant-derived toxins are highly toxic and commonly used in immunotoxins, their immunogenicity for human restricted their application in cancer therapy. Here, we discuss the advantages and limitations of bacterial toxins such as Pseudomonas and Diphtheria toxins, plant toxins such as ricin and gelonin, and some endogenous protein of human origin such as RNases and Granzymes...
March 1, 2017: International Reviews of Immunology
https://www.readbyqxmd.com/read/28280987/vestibular-migraine-patients-are-more-anxious-than-migraine-patients-without-vestibular-symptoms
#3
Özge Kutay, Gülden Akdal, Pembe Keskinoğlu, Birgül Dönmez Balcı, Tunç Alkın
The link between vertigo and anxiety is well known. The aim of this study is to compare anxiety disorders in 3 groups: patients with vestibular migraine (VM), patients with migraine but without vertigo (MO) and healthy controls (HC).We performed cross-sectional analysis of following tests: (a) Hamilton Anxiety Rating Scale (HAMA); (b) State-Trait Anxiety Inventory (STAI-X1 and STAI-X2); (c) Beck Depression Inventory (BDI); (d) Panic-Agoraphobic Scale and (e) Penn State Worry Questionnaire (PSWQ). ANOVA, Kruskal-Wallis and Chi-square tests were used for comparisons and least significant difference was used for further post-hoc analysis...
March 9, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28268845/study-of-functional-brain-homogeneity-in-female-patients-with-major-depressive-disorder
#4
X Zhang, Y Tang, Y Zhu, Y Li, S Tong
Women are at a twofold higher risk of developing major depressive disorder (MDD) than that of men. However, the investigation of female MDD patients functional brain activity is rare and the detailed mechanism remains unclear. The present work is to explore the altered spontaneous neural activity measured with regional homogeneity (ReHo) in female MDD patients using resting-state functional magnetic resonance imaging (fMRI) technique. Twelve MDD females and twelve matched healthy participants were included in the study...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28263552/polyelectrolyte-layer-by-layer-assembly-on-organic-electrochemical-transistors
#5
Anna-Maria Pappa, Sahika Inal, Kirsty Roy, Yi Zhang, Charalampos Pitsalidis, Adel Hama, Jolien Pas, George G Malliaras, Roisin M Owens
Oppositely charged polyelectrolyte multilayers (PEMs) were built-up in a layer-by-layer (LbL) assembly on top of the conducting polymer channel of an organic electrochemical transistor (OECT), aiming to combine the advantages of well-established PEMs with a high performance electronic transducer. The multilayered film is a model system to investigate the impact of biofunctionalization on the operation of OECTs comprising a poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) film as the active layer...
March 6, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28256593/trip13-deficient-tubular-epithelial-cells-are-susceptible-to-apoptosis-following-acute-kidney-injury
#6
Jeffrey D Pressly, Taketsugu Hama, Shannon O' Brien, Kevin R Regner, Frank Park
Damage to renal tubular epithelial cells by genetic, environmental, or biological insults can initiate complex signaling mechanisms that promote kidney repair and functional recovery. In this study, we demonstrated that thyroid receptor interacting protein 13 (TRIP13) is a critical modulator of tubular epithelial cell repair following ischemia-reperfusion injury (IRI), a common type of renal stressor. In Trip13(Gt/Gt)hypomorph mice treated with unilateral renal IRI, persistent tubular epithelial cell damage was determined in the IRI-treated kidney throughout the 168 hours of experimental period compared to the contralateral kidneys...
March 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28247593/c-reactive-protein-symptoms-and-activity-of-daily-living-in-patients-with-advanced-cancer-receiving-palliative-care
#7
Koji Amano, Isseki Maeda, Tatsuya Morita, Mika Baba, Tomofumi Miura, Takashi Hama, Ichiro Mori, Nobuhisa Nakajima, Tomohiro Nishi, Hiroki Sakurai, Satofumi Shimoyama, Takuya Shinjo, Hiroto Shirayama, Takeshi Yamada, Shigeki Ono, Taketoshi Ozawa, Ryo Yamamoto, Naoki Yamamoto, Hideki Shishido, Hiroya Kinoshita
BACKGROUND: The association between C-reactive protein (CRP) level, symptoms, and activities of daily living (ADL) in advanced cancer patients is unclear. METHODS: Secondary data analysis of a multicenter prospective cohort study consisted of 2426 advanced cancer patients referred to palliative care settings was conducted to examine the cross-sectional relationships between CRP level, symptoms, and ADL disabilities. Laboratory data, symptoms, ADL, and manual muscle testing (MMT) results were obtained at baseline...
March 1, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/28239717/simulations-and-spectra-of-water-in-co-matrices
#8
Rafael Escribano, Emilio Artacho, Akira Kouchi, Tetusya Hama, Yuki Kimura, Hiroshi Hidaka, Naoki Watanabe
Models for the inclusion of water molecules in carbon monoxide matrices are developed using density functional theory applied to amorphous solid systems. The models cover a large range of systems for smaller or larger CO matrices with different water content, consisting of either individual H2O molecules or small clusters linked by H-bonds. The vibrational spectra of the samples are predicted at the minimum of their potential energy surface. The spectra allow instances where the water molecules remain isolated or form aggregates to be discerned, and they also provide an indication of the strength of the H-bonding, when present...
February 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28239516/nonmotor-symptoms-in-primary-adult-onset-cervical-dystonia-and-blepharospasm
#9
Jing Yang, Na Shao, Wei Song, Qianqian Wei, Ruwei Ou, Ying Wu, Hui-Fang Shang
BACKGROUND: The nature and frequency of nonmotor symptoms in primary adult-onset cervical dystonia (CD) and blepharospasm (BSP) patients in Chinese populations remain unknown. METHODS: Hamilton's Depression Scale (HAMD), Hamilton's Anxiety Scale (HAMA), Addenbrooke's Cognitive Examination Revised (ACE-R), Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale were used to evaluate NMS in 120 patients with primary focal adult-onset dystonia (60 with BSP and 60 with CD) and 60 age-, sex-, and education level- matched healthy controls (HCs)...
February 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28229956/development-of-a-thermosensitive-hama-containing-bio-ink-for-the-fabrication-of-composite-cartilage-repair-constructs
#10
Vivian Hilda Maria Mouser, Anna Abbadessa, Riccardo Levato, Wim Hennink, Tina Vermonden, Debby Gawlitta, Jos Malda
Fine-tuning of bio-ink composition and material processing parameters is crucial for the development of biomechanically relevant cartilage constructs. This study aims to design and develop cartilage constructs with tunable internal architectures and relevant mechanical properties. More specifically, the potential of methacrylated hyaluronic acid (HAMA) added to thermosensitive hydrogels composed of methacrylated poly[N-(2-hydroxypropyl)methacrylamide mono/dilactate] (pHPMA-lac)/polyethylene glycol (PEG) triblock copolymers, to optimize cartilage-like tissue formation by embedded chondrocytes, and enhance printability was explored...
February 23, 2017: Biofabrication
https://www.readbyqxmd.com/read/28227043/study-of-functional-brain-homogeneity-in-female-patients-with-major-depressive-disorder
#11
X Zhang, Y Tang, Y Zhu, Y Li, S Tong, X Zhang, Y Tang, Y Zhu, Y Li, S Tong, Y Li, Y Zhu, S Tong, X Zhang, Y Tang
Women are at a twofold higher risk of developing major depressive disorder (MDD) than that of men. However, the investigation of female MDD patients functional brain activity is rare and the detailed mechanism remains unclear. The present work is to explore the altered spontaneous neural activity measured with regional homogeneity (ReHo) in female MDD patients using resting-state functional magnetic resonance imaging (fMRI) technique. Twelve MDD females and twelve matched healthy participants were included in the study...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28222332/acquisition-of-vowel-articulation-in-childhood-investigated-by-acoustic-to-articulatory-inversion
#12
Hiroki Oohashi, Hama Watanabe, Gentaro Taga
While the acoustical features of speech sounds in children have been extensively studied, limited information is available as to their articulation during speech production. Instead of directly measuring articulatory movements, this study used an acoustic-to-articulatory inversion model with scalable vocal tract size to estimate developmental changes in articulatory state during vowel production. Using a pseudo-inverse Jacobian matrix of a model mapping seven articulatory parameters to acoustic ones, the formant frequencies of each vowel produced by three Japanese children over time at ages between 6 and 60 months were transformed into articulatory parameters...
February 18, 2017: Infant Behavior & Development
https://www.readbyqxmd.com/read/28216244/safety-and-efficacy-of-pfspz-vaccine-against-plasmodium-falciparum-via-direct-venous-inoculation-in-healthy-malaria-exposed-adults-in-mali-a-randomised-double-blind-phase-1-trial
#13
Mahamadou S Sissoko, Sara A Healy, Abdoulaye Katile, Freda Omaswa, Irfan Zaidi, Erin E Gabriel, Bourama Kamate, Yacouba Samake, Merepen A Guindo, Amagana Dolo, Amadou Niangaly, Karamoko Niaré, Amatigue Zeguime, Kourane Sissoko, Hama Diallo, Ismaila Thera, Kelly Ding, Michael P Fay, Elise M O'Connell, Thomas B Nutman, Sharon Wong-Madden, Tooba Murshedkar, Adam J Ruben, Minglin Li, Yonas Abebe, Anita Manoj, Anusha Gunasekera, Sumana Chakravarty, B Kim Lee Sim, Peter F Billingsley, Eric R James, Michael Walther, Thomas L Richie, Stephen L Hoffman, Ogobara Doumbo, Patrick E Duffy
BACKGROUND: Plasmodium falciparum sporozite (PfSPZ) Vaccine is a metabolically active, non-replicating, whole malaria sporozoite vaccine that has been reported to be safe and protective against P falciparum controlled human malaria infection in malaria-naive individuals. We aimed to assess the safety and protective efficacy of PfSPZ Vaccine against naturally acquired P falciparum in malaria-experienced adults in Mali. METHODS: After an open-label dose-escalation study in a pilot safety cohort, we did a double-blind, randomised, placebo-controlled trial based in Donéguébougou and surrounding villages in Mali...
February 16, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28203485/relationship-of-circulating-cxcr4-epc-with-prognosis-of-mild-traumatic-brain-injury-patients
#14
Yunpeng Lin, Lan Lan Luo, Jian Sun, Weiwei Gao, Ye Tian, Eugene Park, Andrew Baker, Jieli Chen, Rongcai Jiang, Jianning Zhang
To investigate the changes of circulating endothelial progenitor cells (EPCs) and stromal cell-derived factor-1α (SDF-1α)/CXCR4 expression in patients with mild traumatic brain injury (TBI) and the correlation between EPC level and the prognosis of mild TBI. 72 TBI patients (57 mild TBI, 15 moderate TBI patients) and 25 healthy subjects (control) were included. The number of circulating EPCs, CD34(+), and CD133(+) cells and the percentage of CXCR4(+) cells in each cell population at 1,4,7,14,21 days after TBI were counted by flow cytometer...
February 2017: Aging and Disease
https://www.readbyqxmd.com/read/28196885/hemoglobin-phase-of-oxygenation-and-deoxygenation-in-early-brain-development-measured-using-fnirs
#15
Hama Watanabe, Yoshihiko Shitara, Yoshinori Aoki, Takanobu Inoue, Shinya Tsuchida, Naoto Takahashi, Gentaro Taga
A crucial issue in neonatal medicine is the impact of preterm birth on the developmental trajectory of the brain. Although a growing number of studies have shown alterations in the structure and function of the brain in preterm-born infants, we propose a method to detect subtle differences in neurovascular and metabolic functions in neonates and infants. Functional near-infrared spectroscopy (fNIRS) was used to obtain time-averaged phase differences between spontaneous low-frequency (less than 0.1 Hz) oscillatory changes in oxygenated hemoglobin (oxy-Hb) and those in deoxygenated hemoglobin (deoxy-Hb)...
February 28, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28188754/nutm2a-cic-fusion-small-round-cell-sarcoma-a-genetically-distinct-variant-of-cic-rearranged-sarcoma
#16
Shintaro Sugita, Yasuhito Arai, Tomoyuki Aoyama, Hiroko Asanuma, Wakako Mukai, Natsuko Hama, Makoto Emori, Tatsuhiro Shibata, Tadashi Hasegawa
CIC-rearranged sarcoma is a new entity of undifferentiated small round cell sarcoma characterized by chimeric fusions with CIC-rearrangement. We report a NUTM2A-CIC fusion sarcoma in a 43-year-old woman who died of rapidly progressive disease. Histologic analysis revealed multinodular proliferation of small round tumor cells with mild nuclear pleomorphism. The sclerotic fibrous septa separated the tumor into multiple nodules. Immunohistochemistry showed that the tumor cells were diffusely positive for vimentin, focally positive for cytokeratin, and negative for CD99 and NKX2...
February 8, 2017: Human Pathology
https://www.readbyqxmd.com/read/28174406/-suspended-ventricular-septal-defect-closure-due-to-heparin-resistance-report-of-a-case
#17
Yasuyuki Toyoda, Takahiro Takemura, Kazuaki Shiratori, Yasutoshi Tsuda, Gentaku Hama, Hirokazu Niitsu, Yujiro Kawai, Hirozo Kinami, Takehito Yokoyama, Yoshiharu Okada
We present a case of heparin resistance whereby open heart surgery was discontinued. A 53-year-old woman who was diagnosed with ventricular septal defect and atrial septal defect was scheduled for intracardiac repair. However, after intravenous heparin (400 U kg-1) supplementation, the activated clotting time (ACT) increased only to seconds. The operation was discontinued because the addition of heparin( 200 U kg-1) did not show sufficient prolongation of ACT, fully indicative of heparin resistance. Additional antithrombin III concentrate was also ineffective...
February 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28174364/evaluation-of-periodontal-changes-adjacent-to-extraction-sites-during-upper-canine-retraction
#18
Azzam Al-Jundi, Basem Al Sabbagh, Jagan K Baskaradoss
INTRODUCTION: There is an intimate relationship between orthodontic therapy and the periodontal changes that occur during tooth movement. MATERIALS AND METHODS: This prospective clinical trial aims at investigating the movement of both the free and attached gingiva, as well as the movement of the alveolar bone in the extraction site of the upper 1st premolars during the retraction of the upper canines. In this study, 17 patients (10 female, 7 male) requiring 1st premolar extraction before orthodontic tooth movement were selected and treated at the Department of Orthodontics in the Faculty of Dentistry in University of Hama, Hama, Syria...
February 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28157588/new-design-of-experiment-combined-with-uv-vis-spectroscopy-for-extraction-and-estimation-of-polyphenols-from-basil-seeds-red-seeds-sesame-seeds-and-ajwan-seeds
#19
Fazal Mabood, Syed Abdullah Gilani, Javid Hussain, Sulaiman Alshidani, Said Alghawi, Mohammed Albroumi, Saif Alameri, Farah Jabeen, Zahid Hussain, Ahmed Al-Harrasi, Zahra K M Al Abri, Saima Farooq, Zakira Naureen, Ahmad Hamaed, M Rasul Jan, Jasmin Shah
New experimental designs for the extraction of polyphenols from different seeds including Basil seed, Red seed, Sesame seeds and Ajwan seeds were investigated. Four variables the concentration and volume of methanol and NaOH solutions as well as the temperature and time of extraction were varied to see their effect on total phenol extraction. The temperature was varied in the range from 25°C to 200°C while the time in the range from 30 to 200minutes. Response surface methodology was used to optimize the extraction parameters...
January 26, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28133351/-a-case-of-duodenal-papilla-cancer-22-years-after-total-proctocolectomy-for-familial-adenomatous-polyposis
#20
Takashi Takeda, Masakazu Miyake, Mamoru Uemura, Masataka Ikeda, Sakae Maeda, Kazuyoshi Yamamoto, Naoki Hama, Kazuhiro Nishikawa, Atsushi Miyamoto, Michihiko Miyazaki, Motohiro Hirao, Shoji Nakamori, Mitsugu Sekimoto
Familial adenomatous polyposis has an autosomal dominant pattern of inheritance. Colon cancer occurs frequently as a result of colorectal adenoma. The standard treatment is total proctocolectomy. However, it is reported that duodenal papilla cancer and desmoid tumors can also occur alongside colon cancer. We report a patient with duodenal papilla cancer who underwent total proctocolectomy 22 years previously. The patient was a 47-year-old man who had undergone a total proctocolectomy at the age of 25 years for familial adenomatous polyposis...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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