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Ru Bai, Shuang Liu, Yueyin Zhao, Yuqi Cheng, Shu Li, Aiyun Lai, Zhongqi Xie, Xinyu Xu, Zhaoping Lu, Jian Xu
Depressive and anxiety disorders are frequently observed in patients with Systemic Lupus Erythematosus (SLE). However, the underlying mechanisms are still unknown. We conducted this survey to understand the prevalence of depression and anxiety in SLE patients without major neuropsychiatric manifestations (non-NPSLE) and to explore the relationship between emotional disorders, symptoms, autoantibodies, disease activity, and treatments in SLE. 176 SLE patients were included, and SLE disease activity index (SLEDAI), Hamilton Depression Rating Scale (HAMD), and Hamilton Anxiety Rating Scale (HAMA) were recorded to evaluate their disease activity and emotional status...
2016: Journal of Immunology Research
Ismaeel Baba-Rasul, Hemin M Hama Ameen, Awder Khazendar, Seerwan O Hasan
BACKGROUND: Isolated lower segment sacral fracture is very rare. To the best of our knowledge, there is only one case report of S4 stable fracture that was treated conservatively. CASE DESCRIPTION: Here, we report a 12-year-old female child who sustained isolated S5 fracture with anterior displacement of S5 and coccyx on S4. The patient was initially provided with conservative management for one month and twenty-five days. On the failure of this treatment procedure, the patient was treated surgically by partial coccygectomy with S4-S5 fixation after reduction by two K-wires...
October 13, 2016: World Neurosurgery
X-M Wang, Y-G Zhang, A-L Li, Z-H Long, D Wang, X-X Li, J-H Xia, S-Y Luo, Y-H Shan
OBJECTIVE: The present study aims to investigate the relationship between expression of inflammatory cytokines in the peripheral blood and the severity of depression and anxiety in patients with Parkinson's disease (PD). PATIENTS AND METHODS: Between January 2012 and December 2015, 62 PD patients admitted to our institution were included in the PD group, and 62 healthy subjects seeking health check-up at our institution during the same period of time were enrolled in the control group...
September 2016: European Review for Medical and Pharmacological Sciences
Yuko Shima, Koichi Nakanishi, Masashi Sato, Taketsugu Hama, Hironobu Mukaiyama, Hiroko Togawa, Ryojiro Tanaka, Kandai Nozu, Mayumi Sako, Kazumoto Iijima, Hiroyuki Suzuki, Norishige Yoshikawa
BACKGROUND: Despite a low incidence, nephrotic syndrome (NS) can present with IgA nephropathy (IgAN). The clinical characteristics and long-term outcomes of pediatric patients with IgAN presenting with NS (NS-IgAN) at onset have not been fully elucidated. METHODS: We retrospectively analyzed 426 patients, and compared clinical and pathological (Oxford) findings between those with NS-IgAN and those with non-NS-IgAN. RESULTS: Among 426 patients, 30 (7...
October 6, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Chihiro Kamezaki, Ami Nakashima, Asako Yamada, Sachiko Uenishi, Hiroshi Ishibashi, Natsumi Shibuya, Susumu Hama, Shinzo Hosoi, Eiji Yamashita, Kentaro Kogure
Astaxanthin and vitamin E are both effective antioxidants that are frequently used in cosmetics, as food additives, and in to prevent oxidative damage. A combination of astaxanthin and vitamin E would be expected to show an additive anntioxidative effect. In this study, liposomes co-encapsulating astaxanthin and the vitamin E derivatives α-tocopherol (α-T) or tocotrienols (T3) were prepared, and the antioxidative activity of these liposomes toward singlet oxygen and hydroxyl radical was evaluated in vitro...
September 2016: Journal of Clinical Biochemistry and Nutrition
Ismaeel Aghaways, Saman Anwer Wahid, Rawa Hama Ghareeb Ali, Falah Sabir, Fahmi Hussein Kakamad
INTRODUCTION: A large number of complications are reported with the use of IUD. Migration to inguinal region has not been mentioned in literature. We report a rare case of migrated IUD to inguinal canal. CASE REPORT: A 25-year-old lady presented with a painfull mass in the left inguinal region. Diagnostic work up showed migrated IUD to inguinal region. Operation was done and the impacted IUD with surrounding granuloma was retrieved. DISCUSSION: When the string of the IUD is no longer visible at the external os of the cervix, radiological scan must be performed, this should begin with a sonographic examination and plain abdominal radiography may be used to localize the IUD...
September 23, 2016: International Journal of Surgery Case Reports
Andrea Melberg, Abdoulaye Hama Diallo, Thorkild Tylleskär, Karen Marie Moland
BACKGROUND: Facility-based births have been promoted as the main strategy to reduce maternal and neonatal death risks at global scale. To improve birth outcomes, it is critical that health facilities provide quality care. Using a framework to assess quality of care, this paper examines health workers' perceptions about access to facility birth; the effectiveness of the care provided and obstacles to quality birth care in a rural area of Burkina Faso. METHODS: A qualitative study was conducted in 2011 in the Banfora Region, Burkina Faso...
September 29, 2016: BMC Pregnancy and Childbirth
Zhensong Wang, Aiying Zhang, Bin Zhao, Jie Gan, Guangbin Wang, Fei Gao, Bo Liu, Tao Gong, Wen Liu, Richard A E Edden
BACKGROUND: It is increasingly being recognized that alterations of the GABAergic system are implicated in the pathophysiology of depression. This study aimed to explore in vivo gamma-aminobutyric acid (GABA) levels in the anterior cingulate cortex/medial prefrontal cortex (ACC/mPFC) and posterior-cingulate cortex (PCC) of postmenopausal women with depression using magnetic resonance spectroscopy (H-MRS). METHODS: Nineteen postmenopausal women with depression and thirteen healthy controls were enrolled in the study...
September 2016: Medicine (Baltimore)
Awder A Khazendar, Hemin M Hama Ameen, Nzar I Jabbar, Seerwan O Hasan, Talar S Ahmed, Alaa A Ali
BACKGROUND: Intradural extramedullary spinal teratoma (IEST) is a rare condition in adult patients with male predominance. It is commonly associated with spinal dysraphism, lumbar puncture and prior spinal surgeries. The study presents a 37-year-old male diagnosed with upper lumbar intradural extramedullary mature cystic teratoma without dysraphism or prior surgical interventions. CASE DESCRIPTION: Patient's symptoms included a lumbar backache which progressed to the toes, as well as the anterior region of both the thighs...
September 15, 2016: World Neurosurgery
Pim Cuijpers, Claudio Gentili, Rosa M Banos, Javier Garcia-Campayo, Cristina Botella, Ioana A Cristea
Although cognitive and behavioral therapies are effective in the treatment of anxiety disorders, it is not clear what the relative effects of these treatments are. We conducted a meta-analysis of trials comparing cognitive and behavioral therapies with a control condition, in patients with social anxiety disorder (SAD), generalized anxiety disorder (GAD) and panic disorder. We included 42 studies in which generic measures of anxiety were used (BAI, HAMA, STAI-State and Trait). Only the effects of treatment for panic disorder as measured on the BAI (13...
October 2016: Journal of Anxiety Disorders
T S Syunyakov, G G Neznamov
AIM: to summarize the previously published results of a multicenter randomized clinical research phase III study trial of afobazole (INN: fabomotizole) versus diazepam in the treatment of patients with generalized anxiety disorder (GAD) and adjustment disorders (AD). SUBJECTS AND METHODS: Five investigating centers included 150 patients aged 18 to 60 years (60 patients with GAD and 90 with AD) a simple structure of anxiety disorders without concurrent mental, neurological or somatic disorders...
2016: Terapevticheskiĭ Arkhiv
Satoshi Usui, Seiji Hama, Atsushi Tominaga, Yasuyuki Kinoshita, Kaoru Kurisu
OBJECTIVE: The aim of this study was to clarify the correlation between clinical features (especially cyst formation and cavernous sinus invasion) and minor secretion of anterior pituitary hormones, especially adrenocorticotropic hormone (ACTH) and gonadotropin, by clinically nonfunctioning pituitary adenomas (CNFPAs) in cell culture. METHODS: We examined anterior pituitary hormones secreted by samples from 63 cases of CNFPAs grown in cell culture. Magnetic resonance imaging, including determination of the Knosp grade, cystic changes, and intraoperative cavernous sinus invasion, was performed...
September 4, 2016: World Neurosurgery
Thomas Tesson, Mathieu Blot, Aurélie Fillion, Hama Djerad, Joséphine Cagnon-Chapalain, Aline Creuwels, Anne Waldner, Michel Duong, Marielle Buisson, Sophie Mahy, Pascal Chavanet, Lionel Piroth
BACKGROUND: First-line antiretroviral therapy (1(st) ART) is an important step in a patient's management and often considered a long-term therapy at treatment initiation. METHODS: To describe the duration of 1(st) ART and the factors associated with treatment modification in a recent real-life setting, antiretroviral-naïve patients who began their 1(st)ART in six French hospitals in 2009-2012 were included in a cohort. Clinical, immunological, virological and therapeutic data, as well as the reasons for therapeutic changes, if any, were retrospectively collected...
September 7, 2016: Antiviral Therapy
J Yamashita, I Kobayashi, K Tatematsu, H Sezutsu, K Noda, H Ishihara
BACKGROUND: An assay using a mouse antisialyl Lewis X (sLeX) antibody (CSLEX-1) is used clinically for screening and monitoring patients with breast cancer in Japan. However, the IgM isoform of CSLEX-1 is not preferred for the assay because the bulkiness of IgM generally causes poor accessibility to the antigen. To solve this problem, we developed an antisLeX mouse/human chimeric IgG antibody, CH-CSLEX-1, using transgenic silkworms. The performance of a homologous sandwich ELISA of CH-CSLEX1 was then evaluated...
September 2, 2016: Clinical Chemistry
Yosuke Kunishita, Ryusuke Yoshimi, Mitsuhiro Takeno, Shoji Yamanaka, Yumiko Sugiyama, Naomi Tsuchida, Daiga Kishimoto, Reikou Kamiyama, Kaoru Minegishi, Maasa Hama, Yohei Kirino, Yoshiaki Ishigatsubo, Atsuhisa Ueda, Hideaki Nakajima
Multifocal fibrosclerosis (MFS), which causes systemic and chronic connective tissue inflammation, has been associated with IgG4 and regarded as an identical entity with "IgG4-related disease (IgG4-RD)". Although a few cases of MFS mimicking IgG4-RD histopathologically, despite the absence of a serum IgG4 elevation and IgG4-positive plasma cell infiltration, have been reported, there is, so far, little information regarding such exceptional cases. We herein demonstrate a case of non-IgG4-related MFS presenting with periaortitis and parotiditis, whose histological findings were consistent with IgG4-RD despite the absence of elevated serum and tissue IgG4 levels...
2016: Internal Medicine
Masanori Yasuo, Takashi Kobayashi, Mineyuki Hama, Takashi Ichiyama, Toshimichi Horiuchi, Hiroshi Yamamoto, Satoshi Kawakami, Kazutoshi Hamanaka, Takayuki Honda, Masayuki Hanaoka
BACKGROUND: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is frequently applied to the diagnosis of central airway lesions, and endobronchial ultrasound with a guide sheath (EBUS-GS) is mainly used for the diagnosis of peripheral pulmonary lesions. However, there remains an unmet need to improve the diagnostic yields for peribronchial pulmonary lesions located along the secondary/tertiary and fourth/fifth bronchi (the "middle third zone" of the lungs), which neither EBUS-TBNA nor EBUS-GS can easily approach...
September 2016: Respiratory Investigation
Yayoi Tokoro, Masanori Yasuo, Takashi Kobayashi, Mineyuki Hama, Takashi Ichiyama, Toshimichi Horiuchi, Atsuhito Ushiki, Satoshi Kawakami, Takayuki Honda, Masayuki Hanaoka
BACKGROUND: Factors that affect the diagnostic yield in computed tomography (CT)-guided bronchoscopy have not yet been fully evaluated. To improve the diagnostic yield of peripheral pulmonary lesions (PPLs) by CT-guided bronchoscopy, we quantitatively analyzed factors affecting the diagnostic yield. METHODS: The data were collected for 240 PPLs in 237 patients examined by using CT-guided bronchoscopy between October 2003 and November 2011 in our respiratory center...
September 2016: Respiratory Investigation
Kyota Fujita, Kazumi Motoki, Kazuhiko Tagawa, Xigui Chen, Hiroshi Hama, Kazuyuki Nakajima, Hidenori Homma, Takuya Tamura, Hirohisa Watanabe, Masahisa Katsuno, Chiemi Matsumi, Masunori Kajikawa, Takashi Saito, Takaomi Saido, Gen Sobue, Atsushi Miyawaki, Hitoshi Okazawa
Alzheimer's disease (AD) is the most common neurodegenerative disease, but it remains an intractable condition. Its pathogenesis is predominantly attributed to the aggregation and transmission of two molecules, Aβ and tau; however, other pathological mechanisms are possible. Here, we reveal that phosphorylation of MARCKS, a submembrane protein that regulates the stability of the actin network, occurs at Ser46 prior to aggregation of Aβ and is sustained throughout the course of AD in human and mouse brains...
2016: Scientific Reports
D Xu, W Chen, W X Zhou, C D Wang, G J Fei, L M Zhu, H W Xin, D R Zhong, G Sun, X C Fang
OBJECTIVE: To investigate the bowel symptoms and psychological status of patients with irritable bowel syndrome (IBS) with diarrhea (IBS-D), and to verify whether sigmoid colon mucosal mast cells (MCs) and their activation have effect on the symptoms and psychological status of IBS-D patients. METHODS: Patients meeting Rome Ⅲ diagnostic and subtyping criteria of IBS-D who visited the outpatient clinic of gastroenterology of Peking Union Medical College Hospital were consecutively enrolled between July 2009 and June 2012...
August 9, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Kazuo Sugita, Kazuyoshi Kawakami, Takashi Yokokawa, Takahito Sugisaki, Tomomi Takiguchi, Takeshi Aoyama, Kenichi Suzuki, Mitsukuni Suenaga, Kensei Yamaguchi, Ayaka Inoue, Yoshiaki Machida, Toshiharu Yamaguchi, Toshihiro Hama
BACKGROUND: A novel oral agent that consists of trifluridine and tipiracil hydrochloride (TFTD) has been established as salvage-line treatment for metastatic colorectal cancer (mCRC). Adherence to TFTD is crucial to maintaining appropriate curative effects. This study sought to clarify adherence to TFTD and identify candidate factors deteriorating adherence at our institution. METHODS: A total of 50 consecutive mCRC patients who received TFTD monotherapy between June 1, 2014 and July 31, 2015 were analyzed in this study...
2016: Oncology
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