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https://www.readbyqxmd.com/read/29782002/quantitative-and-qualitative-method-for-sphingomyelin-by-lc-ms-using-two-stable-isotopically-labeled-sphingomyelin-species
#1
Kotaro Hama, Yuko Fujiwara, Kazuaki Yokoyama
We present a method of analyzing sphingomyelin (SM) qualitatively and quantitatively by liquid chromatography-electrospray Ionization-tandem mass spectrometry (LC-ESI-MS/MS). SM is a common sphingolipid composed of a phosphorylcholine and a ceramide as the hydrophilic and hydrophobic component, respectively. A number of SM species are present in mammalian cells due to a variety in the sphingoid long chain base (LCB) and an N-acyl moiety in the ceramide. In this report, we show a method of estimating the number of carbon and double bonds in a LCB and an N-acyl moiety based on their corresponding product ions in MS/MS/MS (MS3 ) experiments...
May 7, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29766827/pain-related-behavior-and-brain-activation-in-a-cynomolgus-macaque-model-of-postoperative-pain
#2
Aldric Hama, Takahiro Natsume, Shin'ya Ogawa, Yūji Awaga, Ikuo Hayashi, Akihisa Matsuda, Hiroyuki Takamatsu
BACKGROUND: Inadequate postoperative pain management could lead to persistent pain and this is, in part, due to incomplete understanding of the mechanism of postoperative pain. Currently available rodent models may have limited translatability to clinical postoperative pain. Thus, a preclinical model of postoperative pain was developed in the cynomolgus macaque, a species that is phylogenetically closer to humans than rodents. METHOD: The presence of pressure hypersensitivity was assessed with non-noxious pressure applied proximally and distally (approximately 10 cm) to an abdominal incision in macaques...
May 15, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29758050/an-assessment-of-false-positive-rates-for-malaria-rapid-diagnostic-tests-caused-by-non-plasmodium-infectious-agents-and-immunological-factors
#3
Michelle L Gatton, Sadmir Ciketic, John W Barnwell, Qin Cheng, Peter L Chiodini, Sandra Incardona, David Bell, Jane Cunningham, Iveth J González
BACKGROUND: Malaria rapid diagnostic tests (RDTs) can produce false positive (FP) results in patients with human African trypanosomiasis and rheumatoid factor (RF), but specificity against other infectious agents and immunological factors is largely unknown. Low diagnostic specificity caused by cross-reactivity may lead to over-estimates of the number of malaria cases and over-use of antimalarial drugs, at the cost of not diagnosing and treating the true underlying condition. METHODS: Data from the WHO Malaria RDT Product Testing Programme was analysed to assess FP rates of 221 RDTs against four infectious agents (Chagas, dengue, Leishmaniasis and Schistosomiasis) and four immunological factors (anti-nuclear antibody, human anti-mouse antibody (HAMA), RF and rapid plasma regain)...
2018: PloS One
https://www.readbyqxmd.com/read/29751516/engineering-a-3d-bioprinted-model-of-human-heart-valve-disease-using-nanoindentation-based-biomechanics
#4
Dewy C van der Valk, Casper F T van der Ven, Mark C Blaser, Joshua M Grolman, Pin-Jou Wu, Owen S Fenton, Lang H Lee, Mark W Tibbitt, Jason L Andresen, Jennifer R Wen, Anna H Ha, Fabrizio Buffolo, Alain van Mil, Carlijn V C Bouten, Simon C Body, David J Mooney, Joost P G Sluijter, Masanori Aikawa, Jesper Hjortnaes, Robert Langer, Elena Aikawa
In calcific aortic valve disease (CAVD), microcalcifications originating from nanoscale calcifying vesicles disrupt the aortic valve (AV) leaflets, which consist of three (biomechanically) distinct layers: the fibrosa, spongiosa, and ventricularis. CAVD has no pharmacotherapy and lacks in vitro models as a result of complex valvular biomechanical features surrounding resident mechanosensitive valvular interstitial cells (VICs). We measured layer-specific mechanical properties of the human AV and engineered a three-dimensional (3D)-bioprinted CAVD model that recapitulates leaflet layer biomechanics for the first time...
May 3, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29748849/correlations-between-abnormal-iron-metabolism-and-non-motor-symptoms-in-parkinson-s-disease
#5
Wu Xu, Yan Zhi, Yongsheng Yuan, Bingfeng Zhang, Yuting Shen, Hui Zhang, Kezhong Zhang, Yun Xu
Despite a growing body of evidence suggests that abnormal iron metabolism plays an important role in the pathogenesis of Parkinson's disease (PD), few studies explored its role in non-motor symptoms (NMS) of PD. The present study aimed to investigate the relationship between abnormal iron metabolism and NMS of PD. Seventy PD patients and 64 healthy controls were consecutively recruited to compare serum iron, ceruloplasmin, ferritin, and transferrin levels. We evaluated five classic NMS, including depression, anxiety, pain, sleep disorder, and autonomic dysfunction in PD patients using the Hamilton Depression Scale (HAMD), the Hamilton Anxiety Scale (HAMA), the short form of the McGill Pain Questionnaire, the Pittsburgh Sleep Quality Index and the Scale for Outcomes in Parkinson's disease for Autonomic Symptoms, respectively...
May 10, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29746346/serine-protease-inhibitor-kazal-type-i-spink1-mutation-a-risk-factor-for-early-onset-chronic-pancreatitis
#6
Taketsugu Hama, Naoyuki Nakanishi, Mitsuyoshi Suzuki, Yuko Shima, Hiroyuki Suzuki
No abstract text is available yet for this article.
May 8, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29744414/human-adipose-derived-stem-cells-are-superior-to-human-osteoblasts-hob-in-bone-tissue-engineering-on-a-collagen-fibroin-elr-blend
#7
Esen Sayin, Rosti Hama Rashid, José Carlos Rodríguez-Cabello, Ahmed Elsheikh, Erkan Türker Baran, Vasif Hasirci
The ultrastructure of the bone provides a unique mechanical strength against compressive, torsional and tensional stresses. An elastin-like recombinamer (ELR) with a nucleation sequence for hydroxyapatite was incorporated into films prepared from a collagen - silk fibroin blend carrying microchannel patterns to stimulate anisotropic osteogenesis. SEM and fluorescence microscopy showed the alignment of adipose-derived stem cells (ADSCs) and the human osteoblasts (HOBs) on the ridges and in the grooves of microchannel patterned collagen-fibroin-ELR blend films...
June 2017: Bioactive Materials
https://www.readbyqxmd.com/read/29738418/anxiety-levels-predict-fracture-risk-in-postmenopausal-women-assessed-for-osteoporosis
#8
Antonino Catalano, Gabriella Martino, Federica Bellone, Agostino Gaudio, Carmen Lasco, Viviana Langher, Antonino Lasco, Nunziata Morabito
OBJECTIVE: There has been increasing interest in the association of psychiatric disorders with fracture risk. This study aimed at investigating the role of severity of anxiety in bone health. METHODS: Multiple clinical risk factors for fractures, the Fracture Risk Assessment Tool score, the bone mineral density (BMD) at the lumbar spine and femoral neck, Hamilton Anxiety Rating Scale (HAMA) scores, Beck Depression Inventory scores, and the 36-Item Short Form Health Survey (SF-36) scores for evaluation of the quality of life were determined, and x-ray vertebral morphometry was carried out in postmenopausal women referred for osteoporosis...
May 7, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29707037/efficacy-and-safety-of-a-formulated-herbal-granula-jiu-wei-zhen-xin-for-generalized-anxiety-disorder-a-meta-analysis
#9
Sheng Wang, Lin-Lin Zhao, Xin-Jian Qiu, Dong-Sheng Wang, Tao Tang, Jie-Kun Luo, Sui-Yu Hu, Hui-Yong Huang
Background: The traditional Chinese medicine formula Jiu Wei Zhen Xin Granula (JWZXG) is prescribed to treat generalized anxiety disorder (GAD) in China. This study was to assess the efficacy and safety of JWZXG in patients with GAD. Method: Data were pooled from 14 randomized controlled trials involving the assessment of mean changes of Hamilton Anxiety Rating Scale (HAMA) total scores, response rates, adverse event rates, quality, publication bias, and risk of bias...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29691395/epigenetic-landscape-influences-the-liver-cancer-genome-architecture
#10
Natsuko Hama, Yasushi Totoki, Fumihito Miura, Kenji Tatsuno, Mihoko Saito-Adachi, Hiromi Nakamura, Yasuhito Arai, Fumie Hosoda, Tomoko Urushidate, Shoko Ohashi, Wakako Mukai, Nobuyoshi Hiraoka, Hiroyuki Aburatani, Takashi Ito, Tatsuhiro Shibata
The accumulations of different types of genetic alterations such as nucleotide substitutions, structural rearrangements and viral genome integrations and epigenetic alterations contribute to carcinogenesis. Here, we report correlation between the occurrence of epigenetic features and genetic aberrations by whole-genome bisulfite, whole-genome shotgun, long-read, and virus capture sequencing of 373 liver cancers. Somatic substitutions and rearrangement breakpoints are enriched in tumor-specific hypo-methylated regions with inactive chromatin marks and actively transcribed highly methylated regions in the cancer genome...
April 24, 2018: Nature Communications
https://www.readbyqxmd.com/read/29689690/changes-in-mirna-132-and-mir-124-levels-in-non-treated-and-citalopram-treated-patients-with-depression
#11
Yuan Fang, Qi Qiu, Shengyu Zhang, Lin Sun, Guanjun Li, Shifu Xiao, Xia Li
BACKGROUND: Neurotrophins including brain-derived neurotropic factor (BDNF) are implicated in the pathogenesis of major depressive disorder (MDD). Yet, the roles of brain-specific BDNF-related miRNAs miR-132 and miR-124 are unclear. METHODS: We enrolled 45 treatment-free patients with MDD, 32 citalopram-treated patients with MDD, and 32 healthy control subjects. Participants were assessed with the Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA)...
February 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29689085/determining-the-scope-of-attacks-on-health-in-four-governorates-of-syria-in-2016-results-of-a-field-surveillance-program
#12
Rohini J Haar, Casey B Risko, Sonal Singh, Diana Rayes, Ahmad Albaik, Mohammed Alnajar, Mazen Kewara, Emily Clouse, Elise Baker, Leonard S Rubenstein
BACKGROUND: Violent attacks on and interferences with hospitals, ambulances, health workers, and patients during conflict destroy vital health services during a time when they are most needed and undermine the long-term capacity of the health system. In Syria, such attacks have been frequent and intense and represent grave violations of the Geneva Conventions, but the number reported has varied considerably. A systematic mechanism to document these attacks could assist in designing more protection strategies and play a critical role in influencing policy, promoting justice, and addressing the health needs of the population...
April 2018: PLoS Medicine
https://www.readbyqxmd.com/read/29665568/a-small-proportion-of-litter-derived-nitrogen-is-assimilated-by-plant-biomass-or-immobilized-in-sediments-regardless-of-harvest-management-as-detected-by-15-n-labeled-phragmites-litter-in-a-constructed-wetland
#13
Takashi S T Tanaka, Chagan Irbis, Yuki Hama, Pengyun Wang, Kunzhi Li, Tatsuya Inamura
Emergent aquatic macrophytes play an important role in the removal of nutrients in constructed wetlands (CWs). However, plant biomass supplies litter after the onset of senescence. Although litter-derived nitrogen (N) has been considered a nutrient source for the internal loading that may reduce CW performance, little is known about the quantitative N dynamics associated with litter decomposition. Thus, a controversial question remains about whether plant harvest is needed to manage CWs. In this study, we evaluated the decomposition and the fate of N derived from 15 N-labeled Phragmites litter in a CW for 1 year...
April 14, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29650874/-findings-from-actual-situation-of-cooperation-between-discharge-nurses-and-home-visiting-nurses-from-shifting-to-home-care-through-terminal-phase-in-terminal-cancer-patients
#14
Satomi Konno, Hamae Nagai
We conducted questionnaire surveys focusing on the"actual situation of cooperation between discharge nurses and homevisiting nurses etc. from transition to home-care through the terminal phase in terminal cancer patients."As a result,discharge nurses were employed at acute-stage hospitals to practice discharge adjustment. Medical staff in home care and home care workers continuously supported the patients and their families in managing difficulties such as changes in pathological conditions and care-related anxiety after the patient was discharged...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650868/-present-status-and-problems-of-management-and-guidance-for-visiting-pharmacy-service-to-in-home-patients-by-hospital-pharmacists
#15
Masumi Nakamura, Yoshie Kishita, Miyako Asada, Megumi Otsuka, Sachiko Takeshita, Norihisa Hama, Seigo Hayashi, Tomoki Ito, Masayuki Nishio, Masaki Nakamura
We conducted a survey of the background of 41 patients who received management and guidance from an in-home visiting pharmacy service and of the contents of support by the pharmacist, using patients' medical records from May 2016 to March 2017. Support comprised delivery of medicine to alleviate a burden to caregiver, suggesting medication, adjusting remaining medicines, and providing support during hospitalization. Out of 285 visits, there were 32 visits for which a medical fee could not be claimed. The main reasons for this were delivery of medicine on the day of visiting medical care, management of prescribed medicine at home, and delivery of temporal medicines...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29649479/a-spherical-aberration-free-microscopy-system-for-live-brain-imaging
#16
Yoshihiro Ue, Hiromu Monai, Kaori Higuchi, Daisuke Nishiwaki, Tetsuya Tajima, Kenya Okazaki, Hiroshi Hama, Hajime Hirase, Atsushi Miyawaki
The high-resolution in vivo imaging of mouse brain for quantitative analysis of fine structures, such as dendritic spines, requires objectives with high numerical apertures (NAs) and long working distances (WDs). However, this imaging approach is often hampered by spherical aberration (SA) that results from the mismatch of refractive indices in the optical path and becomes more severe with increasing depth of target from the brain surface. Whereas a revolving objective correction collar has been designed to compensate SA, its adjustment requires manual operation and is inevitably accompanied by considerable focal shift, making it difficult to acquire the best image of a given fluorescent object...
April 9, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29616652/risk-factors-for-in-hospital-maternal-mortality-in-the-region-of-maradi-niger-2008-2010-a-retrospective-study-of-7-regional-maternity-units
#17
Ibrahim Alkassoum, Issifou Djibo, Younsa Hama, A Mohamed Abdoulwahabou, Oumarou Amadou
In the Maradi region, despite multiple efforts to reduce maternal mortality the in-hospital maternal mortality ratio (HMMR) remains high. We sought to determine the factors related to maternal mortality in seven maternity units in this region. A retrospective study reviewed records of deliveries from January, 2008, through December, 2010. Data for all maternal deaths were collected. The Chi2 test was used to determine the significance of differences between groups for the different variables. Statistical significance was defined as P < 0...
February 1, 2018: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/29590107/novel-function-of-hats-and-hdacs-in-homologous-recombination-through-acetylation-of-human-rad52-at-double-strand-break-sites
#18
Takeshi Yasuda, Wataru Kagawa, Tomoo Ogi, Takamitsu A Kato, Takehiro Suzuki, Naoshi Dohmae, Kazuya Takizawa, Yuka Nakazawa, Matthew D Genet, Mika Saotome, Michio Hama, Teruaki Konishi, Nakako Izumi Nakajima, Masaharu Hazawa, Masanori Tomita, Manabu Koike, Katsuko Noshiro, Kenichi Tomiyama, Chizuka Obara, Takaya Gotoh, Ayako Ui, Akira Fujimori, Fumiaki Nakayama, Fumio Hanaoka, Kaoru Sugasawa, Ryuichi Okayasu, Penny A Jeggo, Katsushi Tajima
The p300 and CBP histone acetyltransferases are recruited to DNA double-strand break (DSB) sites where they induce histone acetylation, thereby influencing the chromatin structure and DNA repair process. Whether p300/CBP at DSB sites also acetylate non-histone proteins, and how their acetylation affects DSB repair, remain unknown. Here we show that p300/CBP acetylate RAD52, a human homologous recombination (HR) DNA repair protein, at DSB sites. Using in vitro acetylated RAD52, we identified 13 potential acetylation sites in RAD52 by a mass spectrometry analysis...
March 28, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29562903/towards-characterizing-the-regional-cerebral-perfusion-in-evaluating-the-severity-of-major-depression-disorder-with-spect-ct
#19
Jinming Li, Yuan Yang, Yuankai Zhu, Liqiang Zhou, Yunfeng Han, Tao Yin, Zhaoting Cheng, Guopeng Zhang, Yanxia Shen, Jing Chen
BACKGROUND: Major depressive disorder (MDD) is a common mental disorder worldwide, but now there is a lack of clinically effective assessment and management of MDD. In this study, we used technetium-99 m ethylcysteinate dimer ([99m Tc]ECD) SPECT/CT to characterize the regional cerebral blood flow (rCBF) status of MDD patients, and to explore an objective image assessment model of MDD which is non- or minimally-invasive, convenient and accurate in a clinical setting. METHODS: The severity of MDD was assessed by three trained psychiatrists, based on scores obtained from HAMD and HAMA...
March 21, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29561941/analyzing-the-neuropsychological-characteristics-and-changes-in-serum-markers-of-patients-with-chronic-cerebral-circulation-insufficiency
#20
Jianhua Tang, Yuqing Zhen, Ling Yu, Cui Lv, Juan Zheng, Hui Liang
OBJECTIVE: To investigate the neuropsychological characteristics and changes in CRP, S100B, MBP, HSP-7, and NSE in serum. METHOD: Sixty-six (66) patients treated in our hospital as CCCI group were chosen for our study, and 90 patients with depression were selected as the depression group. The patients in both groups were examined with CT perfusion, depression, anxiety and cognition evaluation. Their serum CRP, S100B, MBP, HSP-70 and NSE levels were detected. Neuropsychological and serum markers characteristics were compared...
January 2018: Revista da Associação Médica Brasileira
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