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https://www.readbyqxmd.com/read/29774599/deep-convolutional-neural-network-for-segmentation-of-knee-joint-anatomy
#1
Zhaoye Zhou, Gengyan Zhao, Richard Kijowski, Fang Liu
PURPOSE: To describe and evaluate a new segmentation method using deep convolutional neural network (CNN), 3D fully connected conditional random field (CRF), and 3D simplex deformable modeling to improve the efficiency and accuracy of knee joint tissue segmentation. METHODS: A segmentation pipeline was built by combining a semantic segmentation CNN, 3D fully connected CRF, and 3D simplex deformable modeling. A convolutional encoder-decoder network was designed as the core of the segmentation method to perform high resolution pixel-wise multi-class tissue classification for 12 different joint structures...
May 17, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29770501/correlation-between-cycling-power-and-muscle-thickness-in-cyclists
#2
Hyung-Jin Lee, Kang-Woo Lee, Yong-Woo Lee, Hee-Jin Kim
INTRODUCTION: The aim of this study was to determine the correlation between muscle thickness (MT) and cycling power in varsity cyclists using ultrasonography (US) and to identify any differences in MT between short- and long-distance cyclists. MATERIALS AND METHODS: Twelve cyclists participated in this study. Real-time two-dimensional B-mode US was used to measure the MT in the anterior thigh, anterior lower leg, and trunk, especially in the abdominal and lumbar regions...
May 17, 2018: Clinical Anatomy
https://www.readbyqxmd.com/read/29768093/alterations-in-kinematics-and-muscle-activation-patterns-with-the-addition-of-a-kipping-action-during-a-pull-up-activity
#3
Christopher Dinunzio, Nathaniel Porter, John Van Scoy, Derrick Cordice, Ryan S McCulloch
Recently, addition of a gymnastics glide kip to a standard pull-up (SPU) has resulted in the kipping pull-up (KPU). Changes in muscle activation and kinematics were evaluated with eleven athletes performing sets of 5 SPU and 5 KPU. Surface electromyography of upper body and lower body muscles was recorded along with movement kinematics obtained via markers and motion tracking software. Most kinematic variables were significantly higher in the KPU including (KPU minus SPU deg): Max hip angle (48.8° ± 6.8°, p < 0...
May 16, 2018: Sports Biomechanics
https://www.readbyqxmd.com/read/29756974/-effects-of-lacto-vegetarian-diet-and-stabilization-core-exercises-on-body-composition-and-pain-in-women-with-fibromyalgia-randomized-controlled-trial
#4
Alejandro Martínez-Rodríguez, Belén Leyva-Vela, Alba Martínez-García, Yolanda Nadal-Nicolás
BACKGROUND: fibromyalgia is a disease of unknown origin characterized by chronic muscular pain. The lack of knowledge about this disease is one of the main causes that makes complex to make a diagnosis and an appropriate treatment. OBJECTIVE: the main objective of this study was to know the efficacy of a physiotherapy treatment combined with a lacto-vegetarian dietary-nutritional intervention, on low back pain and body composition in women with fibromyalgia. METHODS: twenty-one women were randomly divided into three groups: A (core stabilization exercises + lacto-vegetarian diet), B (placebo + lacto-vegetarian diet) and C (control)...
March 1, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29755411/time-of-day-effects-on-metabolic-and-clock-related-adjustments-to-cold
#5
Frederico Sander Mansur Machado, Zhi Zhang, Yan Su, Paul de Goede, Remi Jansen, Ewout Foppen, Cândido Celso Coimbra, Andries Kalsbeek
Background: Daily cyclic changes in environmental conditions are key signals for anticipatory and adaptive adjustments of most living species, including mammals. Lower ambient temperature stimulates the thermogenic activity of brown adipose tissue (BAT) and skeletal muscle. Given that the molecular components of the endogenous biological clock interact with thermal and metabolic mechanisms directly involved in the defense of body temperature, the present study evaluated the differential homeostatic responses to a cold stimulus at distinct time-windows of the light/dark-cycle...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29751221/postmortem-role-of-calpain-11-in-ostrich-skeletal-muscle
#6
Ya-Shiou Chang, Man-Jung Hsu, Rong-Ghi R Chou
The postmortem calpain-11 role in ostrich muscle was investigated. Pairs of ostrich muscle (Iliotibialis cranialis) were excised from 32 ostrich carcasses in 3-h postmortem and randomly assigned into four treatments. The muscle was cut into 2.5-cm thick meat cores. The cores were incubated in 30 mM CaCl2 , 30 mM EDTA, 90 mM NaCl, or control. The cores from the left-side carcasses were sampled after 0, 1, 2, and 3 days of incubation at 5 °C, while the right-side meat cores were taken at 1-day and 3-day incubation for shear force measurements...
April 24, 2018: Meat Science
https://www.readbyqxmd.com/read/29746605/daily-variation-of-gene-expression-in-diverse-rat-tissues
#7
Panteleimon D Mavroudis, Debra C DuBois, Richard R Almon, William J Jusko
Circadian information is maintained in mammalian tissues by a cell-autonomous network of transcriptional feedback loops that have evolved to optimally regulate tissue-specific functions. An analysis of daily gene expression in different tissues, as well as an evaluation of inter-tissue circadian variability, is crucial for a systems-level understanding of this transcriptional circuitry. Affymetrix gene chip measurements of liver, muscle, adipose, and lung tissues were obtained from a rich time series light/dark experiment, involving 54 normal rats sacrificed at 18 time points within the 24-hr cycle...
2018: PloS One
https://www.readbyqxmd.com/read/29736731/phthalimido-thiazole-as-privileged-scaffold-activity-against-immature-and-adult-worms-of-schistosoma-mansoni
#8
Sheilla Andrade de Oliveira, Miria de Oliveira Barbosa, Carlos André Laranjeira Miranda Filho, Arsênio Rodrigues Oliveira, Fabiano Amaro de Sousa, Edna de Farias Santiago, Gevanio Bezerra de Oliveira Filho, Paulo André Teixeira de Moraes Gomes, Juliana Maria da Conceição, Fábio André Brayner, Luiz Carlos Alves, Ana Cristina Lima Leite
Phthalimide, 1,3-thiazole, and thiazolidinone cores are considered privileged scaffolds and represent an attractive starting point to design new bioactive compounds for neglected tropical disease (NTD). Schistosomiasis is a NTD, caused by Schistosoma worms which praziquantel (PZQ) is the only drug used to treat humans, but the decrease in the effect after treatment has been reported. Recently, some phthalimide-thiazole derivatives exhibited in vitro antischistosomal activity against adult worms with significant ultrastructural changes and a lower cytotoxic effect on splenocytes...
May 7, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29735719/reduction-of-cellular-nucleic-acid-binding-protein-encoded-by-a-myotonic-dystrophy-type-2-gene-causes-muscle-atrophy
#9
Christina Wei, Lauren Stock, Christiane Schneider-Gold, Claudia Sommer, Nikolai A Timchenko, Lubov Timchenko
Myotonic Dystrophy type 2 (DM2) is a neuromuscular disease caused by an expansion of intronic CCTG repeats in the CNBP gene which encodes a protein regulating translation and transcription. To better understand the role of CNBP in DM2 pathology, we examined skeletal muscle in a new model of Cnbp knock out (KO) mice. This study showed that a loss of Cnbp disturbs myofibrillar sarcomeric organization at birth. Surviving homozygous Cnbp KO mice develop muscle atrophy at young age. Skeletal muscle phenotype in heterozygous Cnbp KO mice was milder, but they develop severe muscle wasting at advanced age...
May 7, 2018: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29727372/the-effect-of-commonly-performed-exercises-on-the-levator-hiatus-area-and-the-length-and-strength-of-pelvic-floor-muscles-in-postpartum-women
#10
Lauren N Siff, Audra J Hill, Samantha J Walters, Ginny Walters, Mark D Walters
OBJECTIVE: The aim oft his study was to compare the effects of 10 common exercises to traditional pelvic floor muscle (PFM) contractions (Kegel) on levator hiatus (LH) area and PFM length and strength. METHODS: This is a cross-sectional study of 15 healthy postpartum women. Ten exercises were studied. These were common variations of leg, core, and back exercises used in yoga, Pilates, strength training, and physical therapy. Each participant performed all 10 exercises at a single visit in 2 examination settings: transperineal ultrasound and perineometry...
May 2, 2018: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29724127/growth-components-of-cow-s-milk-emphasis-on-effects-in-undernourished-children
#11
Benedikte Grenov, Kim F Michaelsen
BACKGROUND: Cow's milk is a core ingredient in foods for prevention and treatment of undernutrition in children. It promotes growth, but there is limited knowledge of which components in milk have growth-stimulating effects. OBJECTIVE: To discuss the growth-stimulating effects of milk in undernourished children with emphasis on protein, lactose, and minerals. METHODS: We reviewed literature on dairy and growth in undernourished children. RESULTS: Cow's milk has a specific stimulating effect on linear growth, even in well-nourished children, and it may stimulate weight gain and muscle accretion in wasted children...
January 1, 2018: Food and Nutrition Bulletin
https://www.readbyqxmd.com/read/29723273/distinct-roles-for-rev-erb%C3%AE-and-rev-erb%C3%AE-in-oxidative-capacity-and-mitochondrial-biogenesis-in-skeletal-muscle
#12
Ariadna Amador, Sean Campbell, Melissa Kazantzis, Gary Lan, Thomas P Burris, Laura A Solt
The nuclear receptors REV-ERBα and REV-ERBβ have been demonstrated to be core members of the circadian clock and participate in the regulation of a diverse set of metabolic functions. Due to their overlapping tissue expression patterns and gene expression profiles, REV-ERBβ is thought to be redundant to REV-ERBα. Recent work has highlighted REV-ERBα's role in the regulation of skeletal muscle oxidative capacity and mitochondrial biogenesis. Considering the similarity between the REV-ERBs and the hypothesized overlap in function, we sought to determine whether REV-ERBβ-deficiency presented with a similar skeletal muscle phenotype as REV-ERBα-deficiency...
2018: PloS One
https://www.readbyqxmd.com/read/29708722/structural-and-functional-components-of-the-skate-sensory-organ-ampullae-of-lorenzini
#13
Xing Zhang, Ke Xia, Lei Lin, Fuming Zhang, Yanlei Yu, Kalib St Ange, Xiaorui Han, Eric Edsinger, Joel Sohn, Robert J Linhardt
The skate, a cartilaginous fish related to sharks and rays, possesses a unique electrosensitive sensory organ known as the ampullae of Lorenzini (AoL). This organ is responsible for the detection of weak electric field changes caused by the muscle contractions of their prey. While keratan sulfate (KS) is believed to be a component of a jelly that fills this sensory organ and has been credited with its high proton conductivity, modern analytical methods have not been applied to its characterization. Surprisingly, total glycosaminoglycan (GAG) analysis demonstrates that the KS from skate jelly is extraordinarily pure, containing no other GAGs...
May 9, 2018: ACS Chemical Biology
https://www.readbyqxmd.com/read/29706723/electromyographic-activity-of-selected-trunk-core-and-thigh-muscles-in-commonly-used-exercises-for-acl-rehabilitation
#14
Omid A Khaiyat, Jessica Norris
[Purpose] Most of rehabilitation programmes for Anterior Cruciate Ligament (ACL) injury focus on quadriceps-hamstrings activation imbalances and less is known about kinetically linked muscles. This study investigated electromyographic activity of selected trunk, core, and thigh muscles during common rehabilitation exercises for ACL injury. [Subjects and Methods] Twelve active female volunteers participated in this cross-sectional laboratory study. Surface EMG was used to compare activation of eight trunk, hip/core, and lower limb muscles: Erector Spinae (ES), Rectus Abdominis (RA), Gluteus Maximus (GM), Vastus Lateralis (VL), Rectus Femoris (RF), Vastus Medialis (VM), Biceps Femoris (BF), and Semitendinosus (ST) during Forward Lunge, Double Leg Raise, Glute Bridge, Sit-Up, and Squat...
April 2018: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29705465/trunk-and-hip-muscle-activation-during-yoga-poses-do-sex-differences-exist
#15
Lori A Bolgla, Leonard Amodio, Kristen Archer, Jillian Estes, Rachelle Leung, Katherine Magoni, Alyssa Mullikin, Dylan Roberts, Mekenzie Weems, Debra Beazley
OBJECTIVE: To compare core activation during yoga between males and females. METHODS: Surface electromyography was used to quantify rectus abdominis (RA), abdominal obliques (AO), lumbar extensors (LE), and gluteus maximus (GMX) activation during four yoga poses. Data were expressed as 100% of a maximum voluntary isometric contraction. Mixed-model 2 × 2 analyses of variance with repeated measures were used to determine between-sex differences in muscle activity...
May 2018: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/29704490/mathematical-modeling-of-atherosclerotic-plaque-destabilization-role-of-neovascularization-and-intraplaque-hemorrhage
#16
Muyi Guo, Yan Cai, Xinke Yao, Zhiyong Li
Observational studies have identified angiogenesis from the adventitial vasa vasorum and intraplaque hemorrhage (IPH) as critical factors in atherosclerotic plaque progression and destabilization. Here we propose a mathematical model incorporating intraplaque neovascularization and hemodynamic calculation with plaque destabilization for the quantitative evaluation of the role of neoangiogenesis and IPH in the vulnerable atherosclerotic plaque formation. An angiogenic microvasculature is generated by two-dimensional nine-point discretization of endothelial cell proliferation and migration from the vasa vasorum...
April 25, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29704484/role-of-the-c-terminus-mobile-domain-of-cardiac-troponin-i-in-the-regulation-of-thin-filament-activation-in-skinned-papillary-muscle-strips
#17
Nazanin Bohlooli Ghashghaee, King-Lun Li, R John Solaro, Wen-Ji Dong
The C-terminus mobile domain of cTnI (cTnI-MD) is a highly conserved region which stabilizes the actin-cTnI interaction during the diastole. Upon Ca2+ -binding to cTnC, cTnI-MD participates in a regulatory switching that involves cTnI to switch from interacting with actin toward interacting with the Ca2+ -regulatory domain of cTnC. Despite many studies targeting the cTnI-MD, the role of this region in the length-dependent activation of cardiac contractility is yet to be determined. The present study investigated the functional consequences of losing the entire cTnI-MD in cTnI(1-167) truncation mutant, as it was exchanged for endogenous cTnI in skinned rat papillary muscle fibers...
April 25, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29701772/inositol-trisphosphate-receptor-mediated-ca2-signalling-stimulates-mitochondrial-function-and-gene-expression-in-core-myopathy-patients
#18
Matteo Suman, Jenny A Sharpe, Robert B Bentham, Vassilios N Kotiadis, Michela Menegollo, Viviana Pignataro, Jordi Molgó, Francesco Muntoni, Michael R Duchen, Elena Pegoraro, Gyorgy Szabadkai
Core myopathies are a group of childhood muscle disorders caused by mutations of the ryanodine receptor (RyR1), the Ca2+ release channel of the sarcoplasmic reticulum. These mutations have previously been associated with elevated inositol trisphosphate receptor (IP3R) levels in skeletal muscle myotubes derived from patients. However, the functional relevance and the relationship of IP3R mediated Ca2+ signalling with the pathophysiology of the disease is unclear. It has also been suggested that mitochondrial dysfunction underlies the development of central and diffuse multi-mini-cores, devoid of mitochondrial activity, which is a key pathological consequence of RyR1 mutations...
April 25, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29691892/congenital-titinopathy-comprehensive-characterisation-and-pathogenic-insights
#19
Emily C Oates, Kristi J Jones, Sandra Donkervoort, Amanda Charlton, Susan Brammah, John E Smith, James S Ware, Kyle S Yau, Lindsay C Swanson, Nicola Whiffin, Anthony J Peduto, Adam Bournazos, Leigh B Waddell, Michelle A Farrar, Hugo A Sampaio, Hooi Ling Teoh, Phillipa J Lamont, David Mowat, Robin B Fitzsimons, Alastair J Corbett, Monique M Ryan, Gina L O'Grady, Sarah A Sandaradura, Roula Ghaoui, Himanshu B Joshi, Jamie L Marshall, Melinda A Nolan, Simranpreet Kaur, Jaya Punetha, Ana Töpf, Elizabeth Harris, Madhura Bakshi, Casie A Genetti, Minttu Marttila, Ulla Werlauff, Nathalie Streichenberger, Alan Pestronk, Ingrid Mazanti, Jason R Pinner, Carole Vuillerot, Carla Grosmann, Ana Camacho, Payam Mohassel, Meganne E Leach, A Reghan Foley, Diana Bharucha-Goebel, James Collins, Anne M Connolly, Heather R Gilbreath, Susan T Iannaccone, Diana Castro, Beryl B Cummings, Richard I Webster, Leïla Lazaro, John Vissing, Sandra Coppens, Nicolas Deconinck, Ho-Ming Luk, Neil H Thomas, Nicola C Foulds, Marjorie A Illingworth, Sian Ellard, Catriona A McLean, Rahul Phadke, Gianina Ravenscroft, Nanna Witting, Peter Hackman, Isabelle Richard, Sandra T Cooper, Erik-Jan Kamsteeg, Eric P Hoffman, Kate Bushby, Volker Straub, Bjarne Udd, Ana Ferreiro, Kathryn N North, Nigel F Clarke, Monkol Lek, Alan H Beggs, Carsten G Bönnemann, Daniel G MacArthur, Henk Granzier, Mark R Davis, Nigel G Laing
OBJECTIVE: Comprehensive clinical characterisation of congenital titinopathy to facilitate diagnosis and management of this important emerging disorder. METHODS: Using massively parallel sequencing we identified 30 patients from 27 families with two pathogenic nonsense, frameshift and/or splice site TTN mutations in trans. We then undertook a detailed analysis of the clinical, histopathology and imaging features of these patients. RESULTS: All patients had prenatal- or early-onset hypotonia and/or congenital contractures...
April 25, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29689197/ari-1-regulates-myonuclear-organization-together-with-parkin-and-is-associated-with-aortic-aneurysms
#20
Kai Li Tan, Nele A Haelterman, Callie S Kwartler, Ellen S Regalado, Pei-Tseng Lee, Sonal Nagarkar-Jaiswal, Dong-Chuan Guo, Lita Duraine, Michael F Wangler, Michael J Bamshad, Deborah A Nickerson, Guang Lin, Dianna M Milewicz, Hugo J Bellen
Nuclei are actively positioned and anchored to the cytoskeleton via the LINC (Linker of Nucleoskeleton and Cytoskeleton) complex. We identified mutations in the Parkin-like E3 ubiquitin ligase Ariadne-1 (Ari-1) that affect the localization and distribution of LINC complex members in Drosophila. ari-1 mutants exhibit nuclear clustering and morphology defects in larval muscles. We show that Ari-1 mono-ubiquitinates the core LINC complex member Koi. Surprisingly, we discovered functional redundancy between Parkin and Ari-1: increasing Parkin expression rescues ari-1 mutant phenotypes and vice versa...
April 23, 2018: Developmental Cell
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