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https://www.readbyqxmd.com/read/29136538/the-impact-of-core-muscles-training-on-the-range-of-anterior-pelvic-tilt-in-subjects-with-increased-stiffness-of-the-hamstrings
#1
Michał Tomasz Kuszewski, Rafał Gnat, Anna Gogola
The aim of this study is to verify the hypotheses that muscular coordination training of the core region in subjects showing increased hamstring stiffness results in an increase in anterior pelvic tilt and that there is a correlation between hamstring stiffness and anterior pelvic tilt. The two-group, non-blinded experimental controlled trial with three repeated measurements of the dependent variables. The experimental group received muscular coordination training during a period of two weeks, control group - no training...
November 11, 2017: Human Movement Science
https://www.readbyqxmd.com/read/29136277/homozygous-xylt2-variants-as-a-cause-of-spondyloocular-syndrome
#2
M Umair, G Eckstein, G Rudolph, T Strom, E Graf, D Hendig, J Hoover, J Alanay, T Meitinger, H Schmidt, W Ahmad
Spondyloocular syndrome (SOS) is a rare autosomal recessive skeletal disorder. Two recent studies have shown that it is the result of biallelic sequence variants in the XYLT2 gene with pleiotropic effects in multiple organs including retina, heart muscle, inner ear, cartilage, and bone. The XYLT2 gene encodes xylosyltransferase 2, which catalyzes the transfer of xylose (monosaccharide) to the core protein of proteoglycans (PG) leading to initiating the process of proteoglycan assembly. SOS was originally characterized in two families A and B of Iraqi and Turkish origin, respectively...
November 14, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/29134705/a-dystroglycan-mutation-p-cys667phe-associated-to-muscle-eye-brain-disease-with-multicystic-leucodystrophy-results-in-er-retention-of-the-mutant-protein
#3
Giulia Signorino, Sonia Covaceuszach, Manuela Bozzi, Wolfgang Hubner, Viola Mönkemöller, Petr V Konarev, Alberto Cassetta, Andrea Brancaccio, Francesca Sciandra
Dystroglycan (DG) is a cell adhesion complex composed by two subunits, the highly glycosylated α-DG and the transmembrane β-DG. In skeletal muscle, DG is involved in dystroglycanopathies, a group of heterogeneous muscular dystrophies characterized by a reduced glycosylation of α-DG. The genes mutated in secondary dystroglycanopathies are involved in the synthesis of O-mannosyl glycans and in the O-mannosylation pathway of α-DG. Mutations in the DG gene (DAG1), causing primary dystroglycanopathies, destabilize the α-DG core protein influencing its binding to modifying enzymes...
November 13, 2017: Human Mutation
https://www.readbyqxmd.com/read/29128256/megf10-related-myopathies-a-new-case-with-adult-onset-disease-with-prominent-respiratory-failure-and-review-of-reported-phenotypes
#4
Elizabeth Harris, Chiara Marini-Bettolo, Ana Töpf, Rita Barresi, Tuomo Polvikovski, Geraldine Bailey, Richard Charlton, James Tellez, Daniel MacArthur, Michela Guglieri, Hanns Lochmüller, Kate Bushby, Volker Straub
Recessive mutations in MEGF10 (multiple epidermal growth factor 10) have been reported in a severe early onset disorder named Early Myopathy, Areflexia, Respiratory Distress and Dysphagia, and a milder form with cores in the muscle biopsy; and a possible genotype-phenotype correlation determining the clinical presentation has been suggested. We undertook exome sequencing in a 66 year old male with a 20 year history of progressive proximal and distal weakness of upper and lower limbs, facial weakness and dysphagia, who developed respiratory failure requiring ventilation while still ambulant in his 50s...
October 12, 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/29122250/trunk-and-hip-muscle-activation-during-yoga-poses-implications-for-physical-therapy-practice
#5
Debra Beazley, Shilpa Patel, Brent Davis, Steven Vinson, Lori Bolgla
OBJECTIVE: To determine and compare activation of core muscles during yoga to traditional back exercises. METHODS: Surface electromyography was used to quantify activation of the rectus abdominis (RA), abdominal obliques (AO), lumbar extensors (LE), and gluteus maximus (GMX) during four yoga poses. Data were expressed as 100% of a maximum voluntary isometric contraction. Separate analyses of variance with repeated measures were used to compare muscle activity across each exercise...
November 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/29121378/myopericytoma-of-the-neck-originating-in-the-middle-scalene-muscle-a-case-report
#6
Mark B Chaskes, John W Bishop, Matthew Bobinski, D Gregory Farwell
We report a case of myopericytoma of the neck. A 23-year-old woman noticed a small, nontender mass in her left supraclavicular fossa. The mass had grown over a period of 5 months, prompting her to seek evaluation. On examination, no motor or sensory deficits were present. Imaging suggested that a mass had originated in the middle scalene muscle. Computed-tomography-guided core needle biopsy demonstrated a spindle-cell neoplasm with smooth-muscle differentiation. Complete surgical excision was performed. Histopathologic and immunohistochemical evaluations of the tissue sample suggested a myopericytoma...
October 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/29115465/trichosanthes%C3%A2-kirilowii-extract-enhances-repair-of-uvb-radiation%C3%A2-induced-dna-damage-by-regulating-bmal1-and-mir%C3%A2-142%C3%A2-3p-in-human-keratinocytes
#7
Ji-Hye Joo, In-Kee Hong, Nam Kyoung Kim, Eunmi Choi
Ultraviolet B (UVB) radiation induces DNA damage, oxidative stress and inflammation, and suppresses the immune system in the skin, which collectively contribute to skin aging and carcinogenesis. The DNA damage response, including DNA repair, can be regulated by the circadian clock and microRNA (miRNA) expression. The aim of the present study was to evaluate the reparative action of Trichosanthes kirilowii extract (TKE) against UVB irradiation‑induced DNA damage in human keratinocytes. TKE demonstrated low cytotoxicity in normal HaCaT keratinocytes at low doses (up to 100 µg/ml)...
October 31, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29112085/diagnosis-and-management-of-paediatric-autoimmune-liver-disease-espghan-hepatology-committee-position-statement
#8
Giorgina Mieli-Vergani, Diego Vergani, Ulrich Baumann, Piotr Czubkowski, Dominique Debray, Antal Dezsofi, Björn Fischler, Girish Gupte, Loreto Hierro, Giuseppe Indolfi, Jörg Jahnel, Françoise Smets, Henkjan J Verkade, Nedim Hadzic
Paediatric autoimmune liver disease is characterised by inflammatory liver histology, circulating autoantibodies and increased levels of IgG, in the absence of a known etiology. Three conditions have a likely autoimmune pathogenesis: autoimmune hepatitis (AIH), autoimmune sclerosing cholangitis (ASC), and de novo AIH after liver transplantation. Two types of paediatric AIH are recognized according to seropositivity for smooth muscle and/or antinuclear antibody (SMA/ANA, AIH-1) or liver kidney microsomal type 1 and/or anti-liver cytosol type 1 antibodies (anti-LKM-1/anti-LC-1; AIH-2)...
November 3, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29102124/transparent-tiger-barb-puntius-tetrazona-a-fish-model-for-in-vivo-analysis-of-nocardial-infection
#9
F Wang, X G Wang, C Liu, O Q Chang, Y Y Feng, L Jiang, K B Li
Nocardiosis afflicts multiple species of cultured fish, resulting in substantial economic losses to the aquaculture industry, however, lack of detailed knowledge on disease pathogenesis has hampered the development of effective prevention and control strategies. In this study, we injected a green fluorescent protein (GFP)-labeled Nocardia seriolae strain into a transparent mutant strain of Tiger barb (Puntius tetrazona) to monitor tissue pathogen accumulation and tissue damage in vivo, and to clarify the relationship between pathogenic processes and overt symptoms...
November 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/29101636/lyp-1-conjugated-nanoparticles-for-magnetic-resonance-imaging-of-triple-negative-breast-cancer
#10
Abedelnasser Abulrob, Slavisa Corluka, Barbara Blasiak, B Gino Falonne, Dragana Ponjevic, John Matyas, Boguslaw Tomanek
PURPOSE: Triple-negative breast cancer (TNBC) does not express estrogen receptor, progesterone receptor, or Her2/neu. Both diagnosis and treatment of TNBC remain a clinical challenge. LyP-1 is a cyclic 9 amino acid peptide that can bind to breast cancer cells. The goal of this study was to design and characterize LyP-1 conjugated to fluorescent iron oxide nanoparticles (LyP-1-Fe3O4-Cy5.5) as a contrast agent for improved and specific magnetic resonance imaging (MRI) in a preclinical model of TNBC...
November 3, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29101613/retained-medullary-cord-extending-to-a-sacral-subcutaneous-meningocele
#11
Nobuya Murakami, Takato Morioka, Takafumi Shimogawa, Kimiaki Hashiguchi, Nobutaka Mukae, Kazuyoshi Uchihashi, Satoshi O Suzuki, Koji Iihara
BACKGROUND: A retained medullary cord (RMC) is a rare closed spinal dysraphism with a robust elongated neural structure continuous from the conus and extending to the dural cul-de-sac. One case extending down to the base of a subcutaneous meningocele at the sacral level has been reported. CLINICAL PRESENTATION: We report on three cases of closed spinal dysraphism, in which a spinal cord-like tethering structure extended out from the dural cul-de-sac and terminated at a skin-covered meningocele sac in the sacrococcygeal region, which was well delineated in curvilinear coronal reconstructed images of 3D-heavily T2-weighted images (3D-hT2WI)...
November 3, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29097202/distinct-amyloid-precursor-protein-processing-machineries-of-the-olfactory-system
#12
Jae Yeon Kim, Ameer Rasheed, Seung-Jun Yoo, So Yeun Kim, Bongki Cho, Gowoon Son, Seong-Woon Yu, Keun-A Chang, Yoo-Hun Suh, Cheil Moon
Processing of amyloid precursor protein (APP) occurs through sequential cleavages first by β-secretase and then by the γ-secretase complex. However, abnormal processing of APP leads to excessive production of β-amyloid (Aβ) in the central nervous system (CNS), an event which is regarded as a primary cause of Alzheimer's disease (AD). In particular, gene mutations of the γ-secretase complex-which contains presenilin 1 or 2 as the catalytic core-could trigger marked Aβ accumulation. Olfactory dysfunction usually occurs before the onset of typical AD-related symptoms (eg, memory loss or muscle retardation), suggesting that the olfactory system may be one of the most vulnerable regions to AD...
October 30, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29095984/comparative-transcriptomics-of-seasonal-phenotypic-flexibility-in-two-north-american-songbirds
#13
Z A Cheviron, D L Swanson
Phenotypic flexibility allows organisms to reversibly alter their phenotypes to match the changing demands of seasonal environments. Because phenotypic flexibility is mediated, at least in part, by changes in gene regulation, comparative transcriptomic studies can provide insights into the mechanistic underpinnings of seasonal phenotypic flexibility, and the extent to which regulatory responses to changing seasons are conserved across species. To begin to address these questions, we sampled individuals of two resident North American songbird species, American goldfinch (Spinus tristis) and black-capped chickadee (Poecile atricapillus) in summer and winter to measure seasonal variation in pectoralis transcriptomic profiles and to identify conserved and species-specific elements of these seasonal profiles...
October 31, 2017: Integrative and Comparative Biology
https://www.readbyqxmd.com/read/29079564/attenuated-superoxide-dismutase-2-activity-induces-atherosclerotic-plaque-instability-during-aging-in-hyperlipidemic-mice
#14
Aleksandr E Vendrov, Mark D Stevenson, Samthosh Alahari, Hua Pan, Samuel A Wickline, Nageswara R Madamanchi, Marschall S Runge
BACKGROUND: Atherosclerosis progression during aging culminates in the development of vulnerable plaques, which may increase the risk of cardiovascular events. Increased generation and/or decreased scavenging of reactive oxygen species in the vascular wall are major contributors to atherogenesis. We previously showed that superoxide dismutase 2 deficiency increased vascular oxidative stress and reduced aortic compliance in aged wild-type mice and that young Apoe(-/-)/Sod2(+/-) had increased mitochondrial DNA damage and atherosclerosis versus young Apoe(-/-) mice...
October 27, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29073097/content-of-mitochondrial-calcium-uniporter-mcu-in-cardiomyocytes-is-regulated-by-microrna-1-in-physiologic-and-pathologic-hypertrophy
#15
Tania Zaglia, Paola Ceriotti, Antonio Campo, Giulia Borile, Andrea Armani, Pierluigi Carullo, Valentina Prando, Raffaele Coppini, Vladimiro Vida, Tomas O Stølen, Wisløff Ulrik, Elisabetta Cerbai, Giovanni Stellin, Giuseppe Faggian, Diego De Stefani, Marco Sandri, Rosario Rizzuto, Fabio Di Lisa, Tullio Pozzan, Daniele Catalucci, Marco Mongillo
The mitochondrial Ca(2+) uniporter complex (MCUC) is a multimeric ion channel which, by tuning Ca(2+) influx into the mitochondrial matrix, finely regulates metabolic energy production. In the heart, this dynamic control of mitochondrial Ca(2+) uptake is fundamental for cardiomyocytes to adapt to either physiologic or pathologic stresses. Mitochondrial calcium uniporter (MCU), which is the core channel subunit of MCUC, has been shown to play a critical role in the response to β-adrenoreceptor stimulation occurring during acute exercise...
October 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29070955/patellofemoral-pain-in-athletes-clinical-perspectives
#16
REVIEW
Farzin Halabchi, Maryam Abolhasani, Maryam Mirshahi, Zahra Alizadeh
Patellofemoral pain (PFP) is a very common problem in athletes who participate in jumping, cutting and pivoting sports. Several risk factors may play a part in the pathogenesis of PFP. Overuse, trauma and intrinsic risk factors are particularly important among athletes. Physical examination has a key role in PFP diagnosis. Furthermore, common risk factors should be investigated, such as hip muscle dysfunction, poor core muscle endurance, muscular tightness, excessive foot pronation and patellar malalignment...
2017: Open Access Journal of Sports Medicine
https://www.readbyqxmd.com/read/29062463/antioxidant-treatment-reduces-formation-of-structural-cores-and-improves-muscle-function-in-ryr1-y522s-wt-mice
#17
Antonio Michelucci, Alessandro De Marco, Flavia A Guarnier, Feliciano Protasi, Simona Boncompagni
Central core disease (CCD) is a congenital myopathy linked to mutations in the ryanodine receptor type 1 (RYR1), the sarcoplasmic reticulum Ca(2+) release channel of skeletal muscle. CCD is characterized by formation of amorphous cores within muscle fibers, lacking mitochondrial activity. In skeletal muscle of RYR1(Y522S/WT) knock-in mice, carrying a human mutation in RYR1 linked to malignant hyperthermia (MH) with cores, oxidative stress is elevated and fibers present severe mitochondrial damage and cores...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29061637/unique-developmental-trajectories-and-genetic-regulation-of-ventricular-and-outflow-tract-progenitors-in-the-zebrafish-second-heart-field
#18
Noelle Paffett-Lugassy, Natasha Novikov, Spencer Jeffrey, Maryline Abrial, Burcu Guner-Ataman, Srinivasan Sakthivel, Caroline E Burns, C Geoffrey Burns
During mammalian embryogenesis, cardiac progenitor cells constituting the second heart field (SHF) give rise to the right ventricle and primitive outflow tract (OFT), the latter of which is particularly vulnerable to developmental malformations that underlie common congenital heart defects. In zebrafish, SHF progenitors produce half of the single ventricle's myocardium and contribute significantly to the OFT. Previous lineage tracing and mutant analyses suggested that SHF ventricular and OFT progenitors co-migrate to the arterial pole of the zebrafish heart tube soon after their specification in the nkx2...
October 23, 2017: Development
https://www.readbyqxmd.com/read/29060921/the-use-of-electromyography-and-magnetic-resonance-imaging-to-evaluate-a-core-strengthening-exercise-programme
#19
Alicja Rutkowska-Kucharska, Agnieszka Szpala
BACKGROUND: The question that was asked in the study was whether a training routine based on curl-up exercises with a load provided by body mass of the person increases local muscle strength or local muscle endurance. OBJECTIVE: The aim of this study was to evaluate the effect of 4 weeks training based on a small load and low movement velocity on electrical activity (EMG), cross-sectional area (CSA) of core stabilisers. METHODS: The EMG activity was measured in the rectus abdominis (RA), obliquus abdominis externus and erector spinae (ES) muscles...
October 13, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/29060180/functional-connectivity-analysis-of-multiplex-muscle-network-across-frequencies
#20
Jennifer N Kerkman, Andreas Daffertshofer, Leonardo L Gollo, Michael Breakspear, Tjeerd W Boonstra
Physiological networks reveal information about the interaction between subsystems of the human body. Here we investigated the interaction between the central nervous system and the musculoskeletal system by mapping functional muscle networks. Muscle networks were extracted using coherence analysis of muscle activity assessed using surface electromyography (EMG). Surface EMG was acquired from 36 muscles distributed throughout the body while participants were standing upright and performing a bimanual pointing task...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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