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https://www.readbyqxmd.com/read/29346385/combined-effectiveness-of-anthelmintic-chemotherapy-and-wash-among-hiv-infected-adults
#1
Arianna R Means, Lisette van Lieshout, Eric Brienen, Krista Yuhas, James P Hughes, Paul Ndungu, Benson Singa, Judd L Walson
INTRODUCTION: Current global helminth control guidelines focus on regular deworming of targeted populations for morbidity control. However, water, sanitation, and hygiene (WASH) interventions may also be important for reducing helminth transmission. We evaluated the impact of different potential helminth protective packages on infection prevalence, including repeated treatment with albendazole and praziquantel with and without WASH access. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a cohort study nested within a randomized trial of empiric deworming of HIV-infected adults in Kenya...
January 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29346367/assessment-of-serum-pharmacokinetics-and-urinary-excretion-of-albendazole-and-its-metabolites-in-human-volunteers
#2
Laura Ceballos, Alejandro Krolewiecki, Marisa Juárez, Laura Moreno, Fabian Schaer, Luis I Alvarez, Rubén Cimino, Judd Walson, Carlos E Lanusse
BACKGROUND: Soil Transmitted Helminth (STH) infections negatively impact physical and mental development in human populations. Current WHO guidelines recommend morbidity control of these infections through mass drug administration (MDA) using albendazole (ABZ) or mebendazole. Despite major reductions in STH associated morbidity globally, not all programs have demonstrated the expected impact on prevalence of parasite infections. These therapeutic failures may be related to poor programmatic coverage, suboptimal adherence or the exposure of parasites to sub-therapeutic drug concentrations...
January 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29329012/oxidative-transformation-kinetics-and-pathways-of-albendazole-from-reactions-with-manganese-dioxide
#3
Sin-Yi Liou, Wan-Ru Chen
Albendazole (ABZ) is a benzimidazole-based veterinary anthelmintic used extensively in the treatment of intestinal parasites. Due to its high hydrophobicity, ABZ tends to accumulate in soils and sediments in the environment. This study aims to investigate ABZ's possible degradation by manganese oxides. Minor effects from ionic strength and metal cations on ABZ degradation were observed. By contrast, decrease of pH greatly enhanced the reaction rate. Surface complexation between ABZ and MnO2 was indicated to be the dominant control in the reaction kinetics...
December 29, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29327323/inclusion-complex-and-nanoclusters-of-cyclodextrin-to-increase-the-solubility-and-efficacy-of-albendazole
#4
P A Pacheco, L N C Rodrigues, J F S Ferreira, A C P Gomes, C J Veríssimo, H Louvandini, R L D Costa, L M Katiki
Albendazole (ABZ), a benzimidazole widely used to control gastrointestinal parasites, is poorly soluble in water, resulting in variable and incomplete bioavailability. This has favored the appearance ABZ-resistant nematodes and, consequently, an increase in its clinical ineffectiveness. Among the pharmaceutical techniques developed to increase drug efficacy, cyclodextrins (CDs) and other polymers have been extensively used with water-insoluble pharmaceutical drugs to increase their solubility and availability...
January 11, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29325510/albendazole-nanocrystals-with-improved-pharmacokinetic-performance-in-mice
#5
Alejandro J Paredes, Sergio Sánchez Bruni, Daniel Allemandi, Carlos Lanusse, Santiago D Palma
AIM: Albendazole (ABZ) is a broad-spectrum antiparasitic agent with poor aqueous solubility, which leads to poor/erratic bioavailability and therapeutic failures. Here, we aimed to produce a novel formulation of ABZ nanocrystals (ABZNC) and assess its pharmacokinetic performance in mice. Results/methodology: ABZNC were prepared by high-pressure homogenization and spray-drying processes. Redispersion capacity and solid yield were measured in order to obtain an optimized product. The final particle size was 415...
February 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/29304756/medical-treatment-of-an%C3%A2-unusual-cerebral-hydatid-disease
#6
Shu Chen, Ning Li, Feifei Yang, Jiqin Wu, Yuekai Hu, Shenglei Yu, Qi Chen, Xuan Wang, Xinyu Wang, Yuanyuan Liu, Jianming Zheng
BACKGROUND: Hydatid disease is a worldwide zoonosis produced by the larval stage of cestodes of the Echinococcus genus. Hydatid disease primarily involves the liver and lungs. The brain is involved in less than 2% of cases. Surgery has long been the only choice for the treatment, but chemotherapy has been successfully replaced surgery in some special cases. CASE PRESENTATION: We report a rare hydatid disease case which presented with multiple lesions in right frontal lobe, an uncommon site, and in the liver and lungs...
January 5, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29291202/taeniasis-a-possible-cause-of-ileal-bleeding
#7
Alessia Settesoldi, Alessandro Tozzi, Ottaviano Tarantino
Taenia spp. are flatworms of the class Cestoda, whose definitive hosts are humans and primates. Human infestation (taeniasis) results from the ingestion of raw meat contaminated with encysted larval tapeworms and is considered relatively harmless and mostly asymptomatic. Anemia is not recognized as a possible sign of taeniasis and taeniasis-induced hemorrhage is not described in medical books. Its therapy is based on anthelmintics such praziquantel, niclosamide or albendazole. Here we describe a case of acute ileal bleeding in an Italian man affected with both Taenia spp...
December 16, 2017: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/29287759/comparative-proteomics-analysis-of-trichinella-spiralis-muscle-larvae-exposure-to-albendazole-sulfoxide-stress
#8
Ruo Yu Peng, Hui Jun Ren, Chun Li Zhang, Pin Lv, Gao Hui Wei, Zhong Quan Wang, Jing Cui, Liang Ming
The drug albendazole (ABZ) has a positive effect against Trichinella spiralis infection and has been used for the treatment and prevention of trichinellosis in both humans and animals. However, the molecular mechanism of ABZ's effects on T. spiralis remains unknown now. Albendazole sulfoxide (ABZSO) is the main intermediary metabolic product of ABZ, and often used as a substitute of ABZ for the metabolism and bioavailability researches. Herein, isobaric tagging reagents for relative and absolute quantification (iTRAQ)-based LC-MS/MS analysis was used to identify the effect of ABZSO on the proteome of T...
December 26, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29250439/the-effect-of-deworming-using-triple-dose-albendazole-on-nutritional-status-of-children-in-perobatang-village-southwest-sumba-indonesia
#9
Saleha Sungkar, Asri S Ridwan, Gladys Kusumowidagdo
High prevalence of STH leads to malnutrition, anemia, cognitive impairment, and growth disorders. Triple-dose albendazole 400 mg is a broad-spectrum anthelminthic; however, its effectiveness varies in every region. This study aims to determine the benefits of deworming using triple-dose albendazole on children's nutritional status in Perobatang Village, Southwest Sumba, Indonesia. This pre-post study was conducted in July 2016 and January 2017. Children aged 1-15 years were asked to collect stool for diagnosis of STH infection (Kato-Katz method), were measured for anthropometry status to obtain the nutritional status, and took albendazole 400 mg for three consecutive days...
2017: Journal of Parasitology Research
https://www.readbyqxmd.com/read/29239572/shrinking-risk-profiles-after-deworming-of-children-in-port-elizabeth-south-africa-with-special-reference-to-ascaris-lumbricoides-and-trichuris-trichiura
#10
Ivan Müller, Stefanie Gall, Lindsey Beyleveld, Markus Gerber, Uwe Pühse, Rosa Du Randt, Peter Steinmann, Leyli Zondie, Cheryl Walter, Jürg Utzinger
Risk maps facilitate discussion among different stakeholders and provide a tool for spatial targeting of health interventions. We present maps documenting shrinking risk profiles after deworming with respect to soil-transmitted helminthiasis among schoolchildren from disadvantaged neighbourhoods in Port Elizabeth, South Africa. Children were examined for soil-transmitted helminth infections using duplicate Kato-Katz thick smears in March 2015, October 2015 and May 2016, and subsequently treated with albendazole after each survey...
November 27, 2017: Geospatial Health
https://www.readbyqxmd.com/read/29232458/the-effectiveness-of-empirical-anti-parasitic-treatment-in-returning-travellers-with-persistent-abdominal-symptoms
#11
Batel Nissan, Tamar Lachish, Eli Schwartz
Background: Persistent abdominal symptoms (PAS) are common among returning-travellers. In the absence of sensitive tests to identify intestinal parasites, gastrointestinal (GI) symptoms often remain a diagnostic challenge. In this study we examined the effectiveness of empirical anti-parasitic treatment in returning-travellers with PAS despite no positive stool-test. Methods: A retrospective study among returning travellers who approached the clinic between the years 2014 and 2016 with GI complaints without a positive stool-test...
January 1, 2018: Journal of Travel Medicine
https://www.readbyqxmd.com/read/29218962/schistosomiasis-and-soil-transmitted-helminthiases-number-of-people-treated-in-2016
#12
(no author information available yet)
No abstract text is available yet for this article.
December 8, 2017: Relevé épidémiologique Hebdomadaire
https://www.readbyqxmd.com/read/29218582/application-of-fluorescence-emission-for-characterization-of-albendazole-and-ricobendazole-micellar-systems-elucidation-of-the-molecular-mechanism-of-drug-solubilization-process
#13
Josefina Priotti, Darío Leonardi, Guillermo Pico, María C Lamas
Albendazole (ABZ) and ricobendazole (RBZ) are referred to as class II compounds in the Biopharmaceutical Classification System. These drugs exhibit poor solubility, which profoundly affects their oral bioavailability. Micellar systems are excellent pharmaceutical tools to enhance solubilization and absorption of poorly soluble compounds. Polysorbate 80 (P80), poloxamer 407 (P407), sodium cholate (Na-C), and sodium deoxycholate (Na-DC) have been selected as surfactants to study the solubilization process of these drugs...
December 7, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29196023/zataria-multiflora-would-attenuate-the-hepatotoxicity-of-long-term-albendazole-treatment-in-mice-with-cystic-echinococcosis
#14
Z Atayi, H Borji, M Moazeni, M Saboor Darbandi, M Heidarpour
Hepatic injury is the major limitation of long-term albendazole administration in patients with cystic echinococcosis (CE), which could give rise to cessation of treatment. The objective of the present study was to evaluate the protective effects of Zataria multiflora aromatic water (AW) against the hepatic injury induced by long-term albendazole treatment in mice with CE. Fifty healthy BALB/c female mice were infected intraperitoneally by injection of 1500 protoscoleces per animal. Five months after infection, the infected animals were divided into five treatment groups including Z...
November 28, 2017: Parasitology International
https://www.readbyqxmd.com/read/29190739/anthelminthic-activity-of-glibenclamide-on-secondary-cystic-echinococcosis-in-mice
#15
Julia A Loos, María Sandra Churio, Andrea C Cumino
Cystic echinococcosis (CE) is a worldwide parasitic zoonosis caused by the larval stage of Echinococcus granulosus. Current chemotherapy against this disease is based on the administration of benzimidazoles (BZMs). However, BZM treatment has a low cure rate and causes several side effects. Therefore, new treatment options are needed. The antidiabetic drug glibenclamide (Glb) is a second-generation sulfonylurea receptor inhibitor that has been shown to be active against protozoan parasites. Hence, we assessed the in vitro and in vivo pharmacological effects of Glb against the larval stage of E...
November 30, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29186570/comparative-efficacy-of-drugs-for-treating-giardiasis-a-systematic-update-of-the-literature-and-network-meta-analysis-of-randomized-clinical-trials
#16
José M Ordóñez-Mena, Noel D McCarthy, Thomas R Fanshawe
Background: Giardiasis is the commonest intestinal protozoal infection worldwide. The current first-choice therapy is metronidazole. Recently, other drugs with potentially higher efficacy or with fewer and milder side effects have increased in popularity, but evidence is limited by a scarcity of randomized controlled trials (RCTs) comparing the many treatment options available. Network meta-analysis (NMA) is a useful tool to compare multiple treatments when there is limited or no direct evidence available...
November 27, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29184259/isolated-peritoneal-mesenteric-and-omental-hydatid-cyst-a-clinicopathologic-narrative-review
#17
REVIEW
Bita Geramizadeh
Hydatid disease (HD) is caused by Echinococcus granulosus and is endemic in many parts of the world. This parasitic tapeworm can produce cysts in almost every organ of the body, with the liver and lung being the most frequently targeted organs. Peritoneum, omentum, and mesentery are among these unusual locations, which can cause diagnostic challenge and treatment delay. This review provides information on the reported cases of the peritoneal, omental, and mesenteric hydatid cyst in the world during the last 20 years...
November 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29184009/disseminated-hydatid-cyst-of-liver-and-lung
#18
Nousheen Iqbal, Muhammad Hussain, Romana Idress, Muhammad Irfan
Hydatid cyst commonly affects liver followed by lung, but rarely affects both organs simultaneously. Here we presented a patient who presented with concurrent involvement of both lungs and liver. Patient presented with dyspnoea and generalised weakness with bilateral rounded opacities throughout the lung field of variable sizes. CT scan chest with contrast showed multiple rounded soft tissue density in both lungs and liver. Patient underwent mini thoracotomy which revealed multiple cystic lesions throughout lung...
November 28, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29178952/status-of-benzimidazole-resistance-in-intestinal-nematode-populations-of-livestock-in-brazil-a-systematic-review
#19
Lauren Hubert Jaeger, Filipe Anibal Carvalho-Costa
BACKGROUND: Benzimidazoles (BZ) are a class of drugs widely used in veterinary and human medicine, creating a great selection pressure and the emergence of BZ resistance. We conducted a systematic review to assess the status of resistance and/or effectiveness reduction of BZ drugs in animal nematodes in Brazil, and make information accessible to the scientific community, as many studies are published in Portuguese. PubMed, SciELO Brasil, LILACS/Bireme, GNTD database, and Google Scholar were searched with no language restrictions...
November 25, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29175395/sorption-of-albendazole-in-sediments-and-soils-isotherms-and-kinetics
#20
Dragana Mutavdžić Pavlović, Antonija Glavač, Mihaela Gluhak, Mislav Runje
Albendazole is a broad-spectrum anthelmintic drug effective against gastrointestinal parasites in humans and animals. Despite the fact that it has been detected in environment (water, sediment and soil), there is no information on its fate in the environment. So, in order to understand the sorption process of albendazole in environment, the sorption mechanism and kinetic properties were investigated through sorption equilibrium and sorption rate experiments. For that purpose, batch sorption of albendazole on five sediment samples and five soil samples from Croatia's region with different physico-chemical properties was investigated...
November 9, 2017: Chemosphere
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