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https://www.readbyqxmd.com/read/29130011/successful-pelvic-resection-for-acetabular-hydatidosis
#1
Canoville Daniel, Hannebicque Matthieu, Rochcongar Goulven, Michon Jocelyn, Dumaine Valérie, Hulet Christophe
Background: Hydatidosis of the bone is a rare occurrence (0.9 to 2.5% of all localization of the disease). In those occurrences, the pelvic bone is the second most frequent localization. Curative treatment of pelvic bone hydatidosis is difficult and a consensus is yet to be found. Clinical Case: We report a case of hydatidosis of the ischium, extended to the homolateral hip. The patient was treated through hip resection using patient-specific cutting guides, followed by total hip reconstruction...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/29119531/the-non-operative-management-of-asymptomatic-liver-hydatids-ending-echinococcophobia
#2
Farrokh Saidi, Farrokh Habibzadeh
BACKGROUND: Cystic echinococcosis is common in many countries and involves the liver in 75% of cases. The current belief is that all incidentally discovered asymptomatic liver hydatids must be subjected to some types of interventional treatments pre-emptively for fear of some presumably impending complications. We conducted this study to assess the prognosis of patients with liver hydatids without any surgical interventions. Furthermore, we tried to predict the outcome of the cyst using two radiological signs...
November 8, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29098107/a-case-of-ruptured-pulmonary-hydatid-cyst-of-the-liver-and-review-of-the-literature
#3
Nilufer Bulut, Sevinc Dagıstanlı
Background: Hydatid cyst is an endemic disease frequently localized to the liver. It is frequently observed in Southeast Europe, Middle East, and Turkey. Although the cyst rupture can occur spontaneously, it can also occur upon albendazole treatment. Its surgical treatment includes cystotomy, capitonnage, and wedge resection. Material-Method: A 56-year-old male immigrant was admitted with fever, pain, and cough. Albendazole treatment was initiated and elective surgery was planned...
2017: Case Reports in Radiology
https://www.readbyqxmd.com/read/29095112/assessment-of-elimination-profile-of-albendazole-residues-in-fish
#4
Zenaís Busatto, Welliton Gonçalves de França, José Eurico Possebon Cyrino, Jonas Augusto Rizzato Paschoal
Few drugs are specifically regulated for aquaculture. Thus this study considered albendazole (ABZ) as a potential drug for use in fish, which, however, is not yet regulated for this application. ABZ is a broad-spectrum anthelmintic approved for farmed ruminants and recently considered for treatment of fish parasites. It is the subject of careful monitoring because of potential residues in animal products. This study evaluated the depletion of ABZ and its main known metabolites: albendazole sulfoxide - ABZSO, albendazole sulfone - ABZSO2 and albendazole amino sulfone - ABZ-2-NH2SO2, in the fillets of the Neotropical Characin pacu, Piaractus mesopotamicus, which were fed diets containing 10 mg ABZ kg(-1) body weight in a single dose...
November 14, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29084213/reassessment-of-areas-with-persistent-lymphatic-filariasis-nine-years-after-cessation-of-mass-drug-administration-in-sri-lanka
#5
Ramakrishna U Rao, Sandhya D Samarasekera, Kumara C Nagodavithana, Tharanga D M Dassanayaka, Manjula W Punchihewa, Udaya S B Ranasinghe, Gary J Weil
BACKGROUND: Sri Lanka was one of the first countries to initiate a lymphatic filariasis (LF) elimination program based on WHO guidelines. The Anti-Filariasis Campaign provided 5 annual rounds of mass drug administration (MDA) with diethylcarbamazine plus albendazole in all 8 endemic districts from 2002-2006. Microfilaremia (Mf) prevalences have been consistently <1% in all sentinel and spot-check sites since 2006, and all evaluation units passed school-based transmission assessment surveys (TAS) in 2013...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29078351/albendazole-and-antibiotics-synergize-to-deliver-short-course-anti-wolbachia-curative-treatments-in-preclinical-models-of-filariasis
#6
Joseph D Turner, Raman Sharma, Ghaith Al Jayoussi, Hayley E Tyrer, Joanne Gamble, Laura Hayward, Richard S Priestley, Emma A Murphy, Jill Davies, David Waterhouse, Darren A N Cook, Rachel H Clare, Andrew Cassidy, Andrew Steven, Kelly L Johnston, John McCall, Louise Ford, Janet Hemingway, Stephen A Ward, Mark J Taylor
Elimination of filariasis requires a macrofilaricide treatment that can be delivered within a 7-day period. Here we have identified a synergy between the anthelmintic albendazole (ABZ) and drugs depleting the filarial endosymbiont Wolbachia, a proven macrofilaricide target, which reduces treatment from several weeks to 7 days in preclinical models. ABZ had negligible effects on Wolbachia but synergized with minocycline or rifampicin (RIF) to deplete symbionts, block embryogenesis, and stop microfilariae production...
October 23, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29071224/process-physicochemical-characterization-and-in-vitro-assessment-of-albendazole-microcrystals
#7
Vandana Kr, Prasanna Raju Yalavarthi, Harini Chowdary Vadlamudi, Jagadesh Kumar Yadav Kalluri, Arun Rasheed
Purpose: Albendazole is a poorly soluble drug which limits its oral bioavailability. The study was focussed to enhance the solubility by in-situ micronization. Methods: Albendazole microcrystals were prepared by solvent change method using gum karaya and hupu gum as stabilizing agents and the effect of each stabilizer on the prepared microcrystals were studied. FT-IR, DSC, XRD and SEM analysis were performed as a part of characterization studies. The formulations were evaluated for micromeritics, solubility and drug release...
September 2017: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29069723/repurposing-albendazole-new-potential-as-a-chemotherapeutic-agent-with-preferential-activity-against-hpv-negative-head-and-neck-squamous-cell-cancer
#8
Farhad Ghasemi, Morgan Black, Frederick Vizeacoumar, Nicole Pinto, Kara M Ruicci, Carson Cao Son Huu Le, Matthew R Lowerison, Hon Sing Leong, John Yoo, Kevin Fung, Danielle MacNeil, David A Palma, Eric Winquist, Joe S Mymryk, Paul C Boutros, Alessandro Datti, John W Barrett, Anthony C Nichols
Albendazole is an anti-helminthic drug that has been shown to exhibit anti-cancer properties, however its activity in head and neck squamous cell cancer (HNSCC) was unknown. Using a series of in vitro assays, we assessed the ability of albendazole to inhibit proliferation in 20 HNSCC cell lines across a range of albendazole doses (1 nM-10 μM). Cell lines that responded to treatment were further examined for cell death, inhibition of migration and cell cycle arrest. Thirteen of fourteen human papillomavirus-negative HNSCC cell lines responded to albendazole, with an average IC50 of 152 nM...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29069158/multiple-anthelmintic-resistance-in-southern-brazil-sheep-flocks
#9
Plínio Aguiar de Oliveira, Beatriz Riet-Correa, Pablo Estima-Silva, Ana Carolina Barreto Coelho, Bianca Lemos Dos Santos, Marco André Paldês Costa, Jerônimo Lopes Ruas, Ana Lucia Schild
Gastrointestinal parasites represent an important cause of reduced productivity of sheep worldwide. As anthelmintic are still the main control tool for these parasites, this work evaluated the efficacy of commercially available active principles in 22 sheep flocks in the southern region of Rio Grande do Sul, Brazil. In each farm 10 sheep were randomly distributed in seven groups with the following treatments: abamectin; albendazole; closantel; levamisole; monepantel; trichlorphon and no anthelmintic (control)...
October 23, 2017: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
https://www.readbyqxmd.com/read/29063894/multiple-parasitic-and-viral-infections-in-a-patient-living-with-hiv-aids-on-antiretroviral-therapy
#10
K Deepika, Nonika Rajkumari, A S Liji, Subhash Chandra Parija, Abdoul Hamide
Patients with human immunodeficiency virus (HIV) infection are more prone for gastrointestinal infections causing diarrhoea, particularly with parasites. Parasitic infections have been regularly reported in such patients. A female patient confirmed positive for HIV 1 on antiretroviral therapy came with complaints of chronic diarrhoea for the past 7 months. Her initial CD4 count was 89 cells/μl of blood, and antibodies to cytomegalovirus and herpes simplex virus 1 and 2 virus were found to be positive in the patient's serum, but there was no HIV-associated retinopathy...
July 2017: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29061197/in-vivo-evaluation-of-the-efficacy-of-sophora-moorcroftiana-alkaloids-in-combination-with-bacillus-calmette-gu%C3%A3-rin-bcg-treatment-for-cystic-echinococcosis-in-mice
#11
G Zhang, J Wang, Y Luo, M Yuan, Q Gao, H Gao, X Song, Y Shi, K Dong, X Ma
Human cystic echinococcosis is a widespread, chronic, endemic, helminthic zoonosis caused by larval tapeworms of the species Echinococcus granulosus. At present, there is no rational and effective therapy for patients with echinococcosis. The present study evaluated whether the combination of alkaloids from Sophora moorcroftiana seeds (SMSa2) and Bacillus Calmette-Guérin (BCG) was effective in the treatment of experimental echinococcosis. After 20 weeks of secondary infection with protoscoleces, mice were randomly allocated to five groups and treated for 6 weeks by daily intragastric administration of albendazole (ABZ, 100 mg/kg), SMSa2 (100 mg/kg), BCG (abdominal subcutaneous injection at 5 × 106 CFU), SMSa2 + BCG (100 mg/kg SMSa2 and 5 × 106 CFU BCG) or normal saline (untreated group), respectively...
October 24, 2017: Journal of Helminthology
https://www.readbyqxmd.com/read/29059186/lymphatic-pathology-in-asymptomatic-and-symptomatic-children-with-wuchereria-bancrofti-infection-in-children-from-odisha-india-and-its-reversal-with-dec-and-albendazole-treatment
#12
RANDOMIZED CONTROLLED TRIAL
Shantanu K Kar, Bhagirathi Dwibedi, Birendra K Das, Bikash K Agrawala, Cherubala P Ramachandran, John Horton
BACKGROUND: Once interruption of transmission of lymphatic filariasis is achieved, morbidity prevention and management becomes more important. A study in Brugia malayi filariasis from India has shown sub-clinical lymphatic pathology with potential reversibility. We studied a Wuchereria bancrofti infected population, the major contributor to LF globally. METHODS: Children aged 5-18 years from Odisha, India were screened for W. bancrofti infection and disease. 102 infected children, 50 with filarial disease and 52 without symptoms were investigated by lymphoscintigraphy and then randomized to receive a supervised single oral dose of DEC and albendazole which was repeated either annually or semi-annually...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29057706/hydatid-cyst-involvement-of-both-pulmonary-arteries-in-a-14-year-old-girl
#13
Mecnun Çetin, Kamuran Karaman, Mesut Özgökçe, Hadi Geylan, Bedrettin Yildizeli
Hydatid disease is the most common mediterranean parasitic infection; it commonly affects the liver and lungs and rarely involves multiple organs. A 14-year-old girl presented with a 1-year history of dyspnoea and fatigue. She was found to have pulmonary hypertension owing to hydatid cysts in the right ventricle and both pulmonary arteries. After administration of albendazole she underwent pulmonary endarterectomy and a calcified hydatid cyst was removed from the right ventricle. She made a complete recovery and remained on albendazole for 6 months...
October 23, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/29050898/sushi-cervice-and-gnathostomiasis-a-case-report-and-review-of-imported-infections
#14
REVIEW
Jordan Leroy, Marjorie Cornu, Anne Sophie Deleplancque, Séverine Loridant, Emmanuel Dutoit, Boualem Sendid
We describe a case of imported cutaneous gnathostomiasis in a Thai patient living in France. Gnathostomiasis is a zoonosis of food origin. The disease is endemic in Southeast Asia and Latin America. However, over the past 30 years, an increasing number of imported cases has been described in Europe and America. The disease is rare in Western Europe and the majority of cases described had a cutaneous clinical presentation. The disease may sometimes be confused with allergy, leading to a delay in diagnosis. Visceral symptoms are rare but may follow severe attacks...
October 16, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29049181/recurrent-multiple-organ-involvement-of-disseminated-alveolar-echinococcosis-in-3-patients-case-report
#15
Leilei Xu, Sikandaer Siyiti, Xinghua Song, Hao Wen, Liwen Ding, Akbar Yunus, Zheng Tian, Chong Wang, Jiangtao Chen
RATIONALE: Alveolar echinococcosis (AE) is a rare but highly malignant form of echinococcosis caused by Echinococcus multilocularis. There have been very few reports on multiple-organ AE, especially AE in bones. Here we report 3 rare cases of disseminated multiple-organ AE from western China and its neighboring areas. PATIENT CONCERNS: Patient 1 had back and left hip pain, headache, and weakness in left lower limb, often with minor epilepsy and fluctuation of blood pressure...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29048588/bertiella-studeri-infection-a-rare-cause-of-chronic-abdominal-pain-in-a-child-from-north-india
#16
Shruti Sharma, Jagadeesh Menon, Sadhna Lal, Babu Ram Thapa
Bertiella is a common parasite seen in non-human primates. It is rarely seen in humans. We present the case of a 2-year-old child with bertiellosis. He had recurrent abdominal pain, and worm fragments were found in stool, which were refractory to albendazole therapy.
October 18, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/29035859/gastrointestinal-nematodes-infections-and-anthelmintic-resistance-in-grazing-sheep-in-the-eastern-inner-mongolia-in-china
#17
Tianlong Han, Min Wang, Guanghe Zhang, Dongsheng Han, Xinwei Li, Guowen Liu, Xiaobing Li, Zhe Wang
Gastrointestinal nematodes (GIN) are a crucial restraint to grazing sheep production worldwide. This study was conducted to determine the infections and anthelmintic resistance (AR) of GIN in pasture-based sheep in the Eastern Inner Mongolia, China. GIN eggs were tested from 600 grazing sheep feces of 10 farms using saturated saline flotation method and McMaster's method. The egg hatch test (EHT) and the faecal egg count reduction test (FECRT) were used to evaluate resistance of GIN to anthelmintics. We found that the average infection rate was 79...
December 20, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/29034951/a-nanocrystal-based-formulation-improves-the-pharmacokinetic-performance-and-therapeutic-response-of-albendazole-in-dogs
#18
Alejandro Javier Paredes, Nicolás Litterio, Alicia Dib, Daniel Alberto Allemandi, Carlos Lanusse, Sergio Sánchez Bruni, Santiago Daniel Palma
OBJECTIVES: Here, we aimed to assess the pharmacokinetic performance and therapeutic response (anthelmintic efficacy) of an albendazole (ABZ) nano-sized formulation in dogs. METHODS: In the pharmacokinetic study, ABZ self-dispersible nanocrystals (SDNCS) and a control formulation were administered orally to healthy dogs (n = 6). The concentrations of the sulphoxide metabolite in plasma were determined by high-performance liquid chromatography. For the anthelmintic efficacy trial, SDNCS and a commercially available formulation of ABZ were given to naturally parasitised dogs...
October 16, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29034651/primary-orbital-hydatid-cyst-a-case-report
#19
Masoud Fallahi Motlagh, Hamid Janghi Aghdam, Behzad Fallahi Motlagh
Hydatid cyst is a rare parasitic infection that involved all organs. It caused by the larval stage of Echinococcus tapeworms. Hydatid cyst of the head and neck is a very rare condition, even in areas where Echinococcus infestation is endemic. Orbital hydatid cyst is extremely rare and accounts for less than 1% of all hydatid cysts. Herein a 24-year-old man with primary orbital hydatid cyst is introduced. He complained from proptosis and diplopia. MRI images revealed a lesion with low signal intensity on T1-weighted images and high signal intensity on T2-weighted images, which displaced the optic nerve inferiorly and the globe inferolateral...
August 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29032596/limited-effect-of-adaptive-immune-response-to-control-encephalitozoonosis
#20
Bohumil Sak, Michaela Kotková, Lenka Hlásková, Martin Kváč
This study revises our understanding of the effectiveness of cell-mediated adaptive immunity and treatment against microsporidia using molecular detection and quantification of microsporidia in immunocompetent C57Bl/6 and immunodeficient CD4(-/-) and CD8(-/-) mice for the first time. We demonstrate an intense dissemination of microsporidia into most organs within the first weeks post infection in all strains of mice, followed by a chronic infection characterized by microsporidia persistence in CD4(-/-) and C57Bl/6 mice and a lethal outcome for CD8(-/-) mice...
October 15, 2017: Parasite Immunology
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