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https://www.readbyqxmd.com/read/28911671/albendazole-residues-in-goat-s-milk-interferences-in-microbial-inhibitor-tests-used-to-detect-antibiotics-in-milk
#1
Tamara Romero, Rafael Althaus, Vicente Javier Moya, María Del Carmen Beltrán, Wim Reybroeck, María Pilar Molina
Albendazole (ABZ) residues in goat's milk and their effect on the response of microbial inhibitor tests used for screening antibiotics were evaluated. A total of 18 Murciano-Granadina goats were treated with ABZ and individually milked once a day over a 7-day period. ABZ quantification was performed by high performance liquid chromatography. The ABZ parent drug was not detected. The maximum concentration of its metabolites (ABZ sulfoxide, ABZ sulfone, and ABZ 2-aminosulfone) was reached on the 1(st) day post treatment (260...
April 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28911129/a-comparative-study-on-the-efficacy-of-praziquantel-and-albendazole-in-the-treatment-of-urinary-schistosomiasis-in-adim-cross-river-state-nigeria
#2
S A Ben, M F Useh
Background: Praziquantel (PZQ) is the current drug of choice for the treatment of urinary schistosomiasis in endemic areas. It is very efficacious, although the potential for the development of resistance has been reported in some endemic areas among human subjects and in animal studies. Its' limitation include high cost and administration of multiple numbers of tablets. Albendazole (ALB) is used in the treatment of intestinal helminths infection. It is a broad-spectrum single-dose antihelminthic with an excellent cure rate and safety criteria...
September 1, 2017: International Health
https://www.readbyqxmd.com/read/28910741/drug-susceptibility-testing-in-microaerophilic-parasites-cysteine-strongly-affects-the-effectivities-of-metronidazole-and-auranofin-a-novel-and-promising-antimicrobial
#3
David Leitsch
The microaerophilic parasites Entamoeba histolytica, Trichomonas vaginalis, and Giardia lamblia annually cause hundreds of millions of human infections which are treated with antiparasitic drugs. Metronidazole is the most often prescribed drug but also other drugs are in use, and novel drugs with improved characteristics are constantly being developed. One of these novel drugs is auranofin, originally an antirheumatic which has been relabelled for the treatment of parasitic infections. Drug effectivity is arguably the most important criterion for its applicability and is commonly assessed in susceptibility assays using in vitro cultures of a given pathogen...
September 5, 2017: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/28906088/bullous-cutaneous-larva-migrans-case-series-and-review-of-atypical-clinical-presentations
#4
Stefano Veraldi, Ermira Çuka, Paolo Pontini, Fabrizio Vaira
Hookworm-related cutaneous larva migrans (HRCLM) is caused by the penetration and migration in the epidermis of larvae of Ancylostoma braziliense and Ancylostoma caninum. It is characterized by slightly raised and erythematous tracks, located especially on the feet. These tracks may be single or multiple, serpiginous or linear, ramified and intertwined, accompanied by pruritus. Atypical clinical presentations of HRCLM are currently more frequent than in the past. We present six patients with bullous HRCLM and discuss the possible pathogenetic factors...
October 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28905295/between-breed-variations-in-resistance-resilience-to-gastrointestinal-nematodes-among-indigenous-goat-breeds-in-uganda
#5
R B Onzima, R Mukiibi, A Ampaire, K K Benda, E Kanis
Gastrointestinal nematodes (GINs), Haemonchus contortus, are a major health problem in goat production. Resistance to H. contortus, the most prevalent GIN in Uganda, was studied among three indigenous goat breeds to assess their differences. Twelve male goats of each breed approximately 7 months old of small East African (SEA), Mubende, and Kigezi goats from smallholder farmers in Arua, Mubende, and Kabale were assembled for the study. At the station, they were dewormed with a combination therapy of the broad-spectrum dewormers closantel and albendazole to free the goats of gastrointestinal parasites...
September 13, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28899836/spinal-hydatid-cyst-disease
#6
Yurdal Gezercan, Ali Ihsan Ökten, Gökhan Çavuş, Vedat Açik, Emre Bilgin
OBJECTIVE: A hydatic cyst (HC) is a zoonotic infection affecting the liver and lungs, with rare spinal involvement. We discuss the long-term results of 8 spinal HC patients who were monitored at our clinic for 7-15 years. METHODS: The demographic data and clinicopathological parameters of 8 spinal HC patients diagnosed between 2000-2016 were evaluated for their contribution to recurrence and long-term follow-up results were examined. RESULTS: Four male and 4 female patients with a median age of 30...
September 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28892575/effects-of-treating-helminths-during-pregnancy-and-early-childhood-on-risk-of-allergy-related-outcomes-follow-up-of-a-randomized-controlled-trial
#7
Benigna Namara, Stephen Nash, Swaib A Lule, Hellen Akurut, Harriet Mpairwe, Florence Akello, Josephine Tumusiime, Moses Kizza, Joyce Kabagenyi, Gyaviira Nkurunungi, Lawrence Muhangi, Emily L Webb, Moses Muwanga, Alison M Elliott
BACKGROUND: Helminth infections, common in low income countries, may protect against allergy-related disease. Early exposure may be key. In the Entebbe Mother and Baby Study, treating helminths during pregnancy resulted in increased eczema rates in early childhood. We followed the cohort to determine whether this translated to increased asthma rates at school-age. METHODS: This randomized, double-blind, placebo-controlled trial, conducted in Entebbe, Uganda, had three interventions...
September 11, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28891597/12-month-longitudinal-parasitological-assessment-of-lymphatic-filariasis-positive-individuals-impact-of-bi-annual-treatment-with-ivermectin-and-albendazole
#8
John N Kanamitie, Collins S Ahorlu, Joseph Otchere, Fred Aboagye-Antwi, Bethel Kwansa-Bentum, Daniel A Boakye, Nana-Kwadwo Biritwum, Michael D Wilson, Dziedzom K de Souza
OBJECTIVE: Mass drug Administration (MDA) for the control of Lymphatic filariasis (LF), in Ghana, started in the year 2000. While this had great success in many implementation units, there remain areas with persistent transmission, after more than 10 years of treatment. A closer examination of the parasite populations could help understand the reasons for persistent infections, and formulatingn appropriate strategies to control LF in these areas of persistent transmission. MATERIALS AND METHODS: In a longitudinal study, we assessed the prevalence of microfilaraemia (mf) in two communities with 12 years of MDA in Ghana...
September 11, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28877573/hookworm-infection-caused-acute-intestinal-bleeding-diagnosed-by-capsule-a-case-report-and-literature-review
#9
Xia Tan, Meichu Cheng, Jie Zhang, Guochun Chen, Di Liu, Yexin Liu, Hong Liu
Hookworm infections are rare causes of acute gastrointestinal bleeding. We report a middle aged man with primary nephrotic syndrome and pulmonary embolism. During the treatment with steroids and anticoagulants, the patient presented acute massive hemorrhage of the gastrointestinal tract. The results of gastroscopy showed red worms in the duodenum. Colonoscopy and CT angiogram of abdomen were unremarkable. Capsule endoscopy revealed fresh blood and multiple hookworms in the jejunum and ileum. Hookworms caused the acute intestinal bleeding...
August 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/28877570/hookworm-infection-a-neglected-cause-of-overt-obscure-gastrointestinal-bleeding
#10
Kun-Yan Wei, Qiong Yan, Bo Tang, Shi-Ming Yang, Peng-Bing Zhang, Ming-Ming Deng, Mu-Han Lü
Hookworm infections are widely prevalent in tropical and subtropical areas, especially in low income regions. In the body, hookworms parasitize the proximal small intestine, leading to chronic intestinal hemorrhage and iron deficiency anemia. Occasionally, hookworms can cause overt gastrointestinal bleeding, but this is often ignored in heavily burdened individuals from endemic infectious areas. A total of 424 patients with overt obscure gastrointestinal bleeding were diagnosed by numerous blood tests or stool examinations as well as esophagogastroduodenoscopy, colonoscopy, capsule endoscopy or double-balloon enteroscopy...
August 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/28871077/treatment-of-hepatic-hydatid-cyst-in-a-7-year-old-boy-using-a-new-type-of-radiofrequency-ablation-electrode
#11
Evanthia Botsa, Ioanna Thanou, Ioannis Nikas, Loukas Thanos
BACKGROUND Radiofrequency ablation has been established as a treatment method for malignancies and some particular cystic lesions, especially in adults. Experience with radiofrequency ablation in the treatment of hydatid cysts, especially in children, is limited. CASE REPORT Although echinococcosis is rare, especially in children, we describe a 7-year-old boy with lung and liver cystic echinococcosis. Diagnosis was established by clinical history and imaging findings and confirmed by positive antiechinococcal antibodies...
September 5, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28865900/a-benzimidazole-derivative-rcb15-in-vitro-induces-the-alternative-energetic-metabolism-and-glycolysis-in-taenia-crassiceps-cysticerci
#12
Guaraciara de Andrade Picanço, Nayana Ferreira de Lima, Carolina Miguel Fraga, Tatiane Luiza da Costa, Eliana Isac, Javier Ambrosio, Rafael Castillo, Marina Clare Vinaud
The emergence of resistance to albendazole has encouraged the search for effective alternatives for cysticercosis and other parasitosis treatment. RCB15 is a benzimidazole derivative that may be used against such diseases. The aim of this study was to determine the in vitro effect of RCB15 on the alternative energetic pathways of Taenia crassiceps cysticerci. The cysticerci were in vitro exposed to albendazole sulphoxide (ABZSO) or RCB15 at different concentrations during 24h. The cysticerci extract and the culture medium were analyzed through spectrophotometry and high performance liquid chromatography as to detect glucose, urea, creatinine and organic acids of the energetic metabolism...
September 1, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28864029/global-deworming-moving-past-albendazole-and-mebendazole
#13
Peter J Hotez
No abstract text is available yet for this article.
August 29, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28864027/efficacy-and-safety-of-tribendimidine-tribendimidine-plus-ivermectin-tribendimidine-plus-oxantel-pamoate-and-albendazole-plus-oxantel-pamoate-against-hookworm-and-concomitant-soil-transmitted-helminth-infections-in-tanzania-and-c%C3%A3-te-d-ivoire-a-randomised-controlled
#14
Wendelin Moser, Jean T Coulibaly, Said M Ali, Shaali M Ame, Amour K Amour, Richard B Yapi, Marco Albonico, Maxim Puchkov, Jörg Huwyler, Jan Hattendorf, Jennifer Keiser
BACKGROUND: Preventive chemotherapy is the current strategy to control soil-transmitted helminth infections (caused by Ascaris lumbricoides, hookworm, and Trichuris trichiura). But, to improve efficacy and avoid emerging resistance, new drugs are warranted. Tribendimidine has shown good anthelmintic efficacy and is therefore a frontrunner for monotherapy and combination chemotherapy. METHODS: We did a randomised, controlled, single-blinded, non-inferiority trial on Pemba Island, Tanzania, and in Côte d'Ivoire...
August 29, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28838923/primary-renal-echinococcosis-with-gross-hydatiduria
#15
Archit Gupta, Jagdish Gupta, Bhavesh Devkaran, Arun Gupta
Renal echinococcosis is a rare disease. It is usually asymptomatic but may present with pain, lump or in rare cases hydatiduria. Diagnosis is mainly by imaging but serology is usually false negative. We present a patient of renal echinococcosis who presented with passing of grape skin like structures in urine and was diagnosed to be a case of renal echinococcosis on the basis of positive serology, ultrasonographic and CT findings. The patient underwent a nephroureterectomy and was given albendazole preoperatively and postoperatively...
August 24, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28831213/cuticular-surface-damage-of-ascaridia-galli-adult-worms-treated-with-veitchia-merrillii-betel-nuts-extract-in-vitro
#16
Ummu Balqis, Muhammad Hambal, Rinidar, Farida Athaillah, Ismail, Azhar, Henni Vanda, Darmawi
AIM: The objective of this research was to in vitro evaluate the cuticular surface damage of Ascaridia galli adult worms treated with ethanolic extract of betel nuts Veitchia merrillii. MATERIALS AND METHODS: Phytochemical screening was done using FeCl3, Wagner and Dragendorff reagents, NaOH, MgHCl, and Liebermann-Burchard reaction test. Amount of 16 worms were segregated into four groups with three replicates. Four worms of each group submerged into phosphate buffered saline, 25 mg/ml, and 75 mg/ml crude ethanolic extract of V...
July 2017: Veterinary World
https://www.readbyqxmd.com/read/28821422/adhesion-molecules-chemokines-and-matrix-metallo-proteinases-response-after-albendazole-and-albendazole-plus-steroid-therapy-in-swine-neurocysticercosis
#17
Satyendra K Singh, Kashi N Prasad, Aloukick K Singh, Kamlesh K Gupta, Amrita Singh, Mukesh Tripathi, Rakesh K Gupta
The treatment of neurocysticercosis (NCC) varies with location, number and stage of the Taenia solium cysticerci (cysts). Albendazole (ABZ) effectively kills cysticerci, and subsequently induces neuro-inflammation facilitated by leukocyte infiltration. We hypothesize that immune response varies around drug responder (degenerating/dying) and non-responder (viable) cysts after ABZ and ABZ plus steroid (ABZS) therapy, which may determine the disease pathogenesis. Twenty cysticercotic swine were treated with ABZ (n = 10; group1) and ABZS (n = 10; group2)...
August 15, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28820693/clinical-features-of-intermittent-migratory-swelling-caused-by-gnathostomiasis-with-complete-follow-up
#18
Chollasap Sharma, Watcharapong Piyaphanee, Dorn Watthanakulpanich
A 15-year-old Thai girl was referred to the Hospital for Tropical Diseases of Mahidol University with a 3-week history of an intermittent migratory mass on the forehead. She was diagnosed with cutaneous gnathostomiasis. The patient was treated with albendazoleat 400 mg orally twice a day for 3 weeks, with good compliance. She revisited the hospital after 3 months and was seen to have been unresponsive to the initial treatment. There was intermittent swelling in her right upper eyelid along with mild redness around her right upper and lower eyelids...
August 7, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28819487/an-evaluation-of-wb123-antibody-elisa-in-individuals-treated-with-ivermectin-and-albendazole-and-implementation-challenges-in-africa
#19
Dziedzom Komi de Souza, Irene Offei Owusu, Joseph Otchere, Michelle Adimazoya, Kwadwo Frempong, Collins Stephen Ahorlu, Daniel Adjei Boakye, Michael David Wilson
The development of antibody testing for the diagnosis of lymphatic filariasis (LF) is intended to enhance the monitoring and evaluation activities of the Global Program for the Elimination of LF. This is due to the fact that antibody tests are expected to be the most sensitive at detecting exposure to LF compared to antigen that takes longer to develop. To this end a new antibody-based enzyme linked immunosorbent assay (ELISA) to Wuchereria bancrofti antigen Wb123 has been developed and further designed into a point of care rapid diagnostic test, under evaluation...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28807628/vertebral-alveolar-echinococcosis-a-case-report-systematic-analysis-and-review-of-the-literature
#20
REVIEW
Thomas Raphael Meinel, Bruno Gottstein, Vanessa Geib, Marius Johann Keel, Ruggero Biral, Markus Mohaupt, Jan Brügger
Alveolar echinococcosis caused by Echinococcus multilocularis is an infrequent zoonosis with a high degree of disability, morbidity, and mortality, especially in disease clusters of the northern hemisphere. The diagnosis is complicated by extended incubation time, diverse clinical manifestations, and mimicking of differential diagnoses. The primary organ affected is the liver, but extrahepatic disease is possible, with vertebral involvement in only a few dozen cases described worldwide. Although vertebral alveolar echinococcosis seems to be rare, it might be under diagnosed, and it might be seen more often as the number of people with immunocompromised conditions increases...
August 11, 2017: Lancet Infectious Diseases
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