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Timothy Baird, Caroline L Cooper, Richard Wong, Naomi Runnegar, Gregory Keir
IgG4-related disease (IgG4-RD) is a systemic fibroinflammatory disease characterized by tumefactive lesions in various organ systems, including the lungs. Clinical and radiological manifestations of IgG4-RD are relatively non-specific, and we report a case highlighting the importance of histopathological confirmation in cases of suspected IgG4-related lung disease. A 44-year-old male with significantly elevated serum IgG4 levels, patchy consolidation on thoracic CT imaging, and cough was referred with suspected IgG4-related lung disease...
January 2018: Respirology Case Reports
Naglaa Fathy Abd El-Aal, Rania Said Hamza, Ola Harb
Schistosomiasis is a chronic helminthic disease causing hepatic fibrosis. Some studies demonstrated direct effect of targeting apoptosis on fibrosis regression. This study is a novel trial of Paeoniflorin (PAE) on S. mansoni induced hepatic fibrosis in murine model compared to Praziquantel (PZQ) evaluating their anti-parasitic and anti-fibrotic properties aiming to discover a new therapy that decrease schistosomiasis morbidity. Thirty two laboratory bred Swiss albino male CD-1 mice were used in this study. The mice were classified into four groups (8 mice each), control healthy, control infected, PZQ treated (300 mg/kg/12 h), PAE treated (50 mg/kg/d) groups...
October 13, 2017: Experimental Parasitology
Naglaa Fathy Abd El-Aal, Rania Said Hamza, Mona Magdy
Angiogenesis is one of the pillars of neoplasia. Lymphangiogenesis in context of granulomas is not yet understood. This study aimed to evaluate the role of praziquantel (PZQ) and artemether (ART) as anti-angiogenic and anti-lymphangiogenic drugs in Schistosoma mansoni induced experimental hepatic model through immunohistochemical and serological studies, this can be used as a potential novel prophylactic approach in hepatic malignancy prevention and possible management. Forty female CD-1 Swiss albino mice were used divided into 4 groups (10 mice each); control healthy, control infected untreated, PZQ-treated and ART-treated...
December 20, 2017: Acta Parasitologica
Sileshi Belew, Sultan Suleman, Evelien Wynendaele, Matthias D'Hondt, Anne Kosgei, Luc Duchateau, Bart De Spiegeleer
Soil-transmitted helminthiasis and schistosomiasis are major public health problems in Ethiopia. Mass deworming of at-risk population using a single dose administration of 400mg albendazole (ABZ) or 500mg mebendazole (MBZ) for treatment of common intestinal worms and 40mg of praziquantel (PZQ) per kg body weight for treatment of schistosomiasis is one of the strategies recommended by World Health Organization (WHO) in order to control the morbidity of soil-transmitted helminthiasis and schistosomiasis. Since storage condition, climate, way of transportation and distribution route could all affect the quality of medicines, regular assessment by surveys is very critical to ensure the therapeutic outcome, to minimize risk of toxicity to the patient and resistance of parasites...
October 13, 2017: Acta Tropica
Nathália Bandeira de Melo, Letícia Fernanda Moreira Dos Santos, Mayara Santos de Castro, Raquel Lopes Martins Souza, Marcos José Marques, Aline Pereira Castro, Andreísa Teixeira de Castro, Marina Lara de Carli, João Adolfo Costa Hanemann, Matheus Siqueira Silva, Gabriel de Oliveira Isac Moraes, Luiz Alberto Beijo, Maísa Ribeiro Pereira Lima Brigagão, Felipe Fornias Sperandio
The purpose of this study was to assess, for the very first time, the effects of photodynamic therapy (PDT) on Schistosoma mansoni in vitro by measuring reactive oxygen species (ROS) generation throughout the treatment, as well as the behavior of the parasites (mating, motility and contraction/shortening), and damage to their tegument and excretory systems. The parasites were divided into 4 groups: control, photosensitizer, laser and PDT. Light irradiation was delivered with an InGaAlP low-level laser device operating at 660nm, with 40mW and 100J/cm(2)...
September 22, 2017: Journal of Photochemistry and Photobiology. B, Biology
Vitor Hugo Balasco Serrão, Humberto D'Muniz Pereira, Juliana Roberta Torini de Souza, Larissa Romanello
BACKGROUND: Schistosoma mansoni is the etiological agent of schistosomiasis, a debilitating treatment neglected tropical disease that affects approximately 218 million people worldwide. Despite its importance, the treatment of schistosomiasis relies on a single drug, praziquantel. Some reports on the resistance of S. mansoni to this drug have stimulated efforts to develop new drugs to treat this disease. S. mansoni possesses all the same pyrimidine pathways (de novo, salvage and thymidylate cycles) as those of its host...
October 11, 2017: Current Pharmaceutical Design
Rebecca Nespoli Lima, Paulo Marcos Zech Coelho, Ana Carolina A Mattos, Clélia Christina Mello Silva, Ronaldo de Carvalho Augusto, Ester Maria Mota, Samaly de Souza, Georgia Correa Atella, Suellen Silva Cabral, George Eduardo Gabriel Kluck, Marta Julia Faro
No abstract text is available yet for this article.
October 7, 2017: Experimental Parasitology
Anh Tran Le, Le-Quyen Thi Do, Huong-Binh Thi Nguyen, Hong-Ngoc Thi Nguyen, Anh Ngoc Do
BACKGROUND: Tapeworms of the genus Spirometra include species whose larval stages can infect humans, causing a disease called sparganosis. Cases of human infection with adult worms are very rare and have been reported in Korea and China. Here we report the first case of human infection with an adult of Spirometra erinaceieuropaei in Vietnam. CASE PRESENTATION: A 23-year-old male was admitted to 103 Military Hospital, Hanoi, Vietnam with fever, weight loss and epigastric discomfort...
October 10, 2017: BMC Infectious Diseases
Alexandra Arion, Emilio Fernández-Varón, Carlos M Cárceles, László Gagyi, Laurent Ognean
Objectives The pharmacokinetics of praziquantel and pyrantel pamoate has never been reported in cats. The present study was designed to establish the plasma concentration-time profile and to derive pharmacokinetic data for a combined formulation of praziquantel and pyrantel in cats, after a single, oral administration. Methods Twenty-two clinically healthy adult cats were used, each receiving a single oral dose of praziquantel (8.5 mg/kg) and pyrantel (100 mg/kg). Blood samples were collected at regular time points up to 48 h post-dosing...
October 1, 2017: Journal of Feline Medicine and Surgery
Nupur Kittur, Sue Binder, Carl H Campbell, Charles H King, Safari Kinung'hi, Annette Olsen, Pascal Magnussen, Daniel G Colley
Preventive chemotherapy with praziquantel for schistosomiasis morbidity control is commonly done by mass drug administration (MDA). MDA regimen is usually based on prevalence in a given area, and effectiveness is evaluated by decreases in prevalence and/or intensity of infection after several years of implementation. Multiple studies and programs now find that even within well-implemented, multiyear, annual MDA programs there often remain locations that do not decline in prevalence and/or intensity to expected levels...
September 25, 2017: American Journal of Tropical Medicine and Hygiene
Ahlam Elmasry, Nabil M Aladeeb, Amro Elkaref, Nora Aboulfotouh
Previous studies on simvastatin use in experimental schistosomiasis in mice did not provide a full explanation of its mechanism as antischisome. In this study, we tried to find out the role of IL-10 in the mechanism of action of simvastatin. We used 50 clear mice. Ten were used as normal not treated while 40 were infected with shistosome mansoni then divided into 4 groups; 3 treated groups by praziquantel, simvastatin and combined (praziquantel plus simvastatin) respectively and one group non-treated. The simvastatin treated group showed shortening and loss of the tubercles and disappearance of the spines with swelling and twisted shape of the worms...
October 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Mona El-Sayad, Sahar Abu Helw, Hend El-Taweel, Mohammad Aziz
BACKGROUND: The development of new antischistosomal drug remains a pressing need and a vital challenge in front of many researchers through screening the natural or chemical substances for their potential activity as antischistosomal agents. METHODS: Five groups of Schistosoma mansoni-infected mice (n=10) were enrolled in this study, the G1 was infected non-treated control group. G2 was infected treated with praziquantel 500 mg/kg for 2 consecutive days. G3 was given mirazid 500 mg/kg for 5 days...
July 2017: Iranian Journal of Parasitology
M S Silva, A P Castro, A T de Castro, I M M Souza, R L Martins-Souza, F A Colombo, T C Elias, M H Santos, M J Marques
Schistosomiasis - caused by trematodes from the genus Schistosoma - affects more than 200 million people worldwide. Growing resistance to therapy with praziquantel (PZQ) has encouraged the search for novel treatments against this neglected disease. The compound 7-epiclusianone (7-epi) - isolated from 'bacupari' (the fruit of the Gracinia brasiliensis tree) - has promising activity against Schistosoma mansoni in vitro, damaging the parasite's tegument. However, the target and mechanism of action of 7-epi have not been identified...
October 4, 2017: Journal of Helminthology
Gordana Panic, Marie-Thérèse Ruf, Jennifer Keiser
To date there is only one drug in use, praziquantel, to treat more than 250 million people afflicted with schistosomiasis, a debilitating parasitic disease. The aryl hydantoin Ro 13-3978 is a promising drug candidate with superior in vivo activity to praziquantel against both adult and juvenile Schistosoma mansoni Given the drugs' contrasting low activity in vitro, and the timing of its onset of action in vivo, it was postulated that immune-assisted parasite clearance could contribute to the drug's in vivo activity...
October 2, 2017: Antimicrobial Agents and Chemotherapy
Rukeme M Noriode, Emmanuel T Idowu, Olubunmi A Otubanjo, Margaret A Mafe
BACKGROUND: Urinary schistosomiasis is endemic in many rural communities of Nigeria and school aged children are mostly affected. A cross-sectional study was carried out to assess the prevalence and intensity of urinary schistosomiasis infection among 251 school aged children in two communities of Ovia South West LGA of Edo State, Nigeria, as well as their knowledge on the control/elimination measures. METHODS: Urine samples were collected and examined by microscopy using filtration technique...
September 29, 2017: Journal of Infection and Public Health
Xiaofeng Luo, Yuxiao Zhu, Ran Liu, Jingwei Song, Fan Zhang, Wenyue Zhang, Zhipeng Xu, Min Hou, Bingya Yang, Lin Chen, Minjun Ji
BACKGROUND: Epidemiological studies in China have revealed that Schistosoma japonicum infection is inversely correlated with metabolic syndrome, even after repeated chemotherapy with praziquantel (PZQ). We investigated the effect of chronic S. japonicum infection, PZQ chemotherapy, and soluble egg antigen (SEA) treatment on whole-body metabolic homeostasis and hepatic insulin sensitivity in mouse models. RESULTS: Infection with S. japonicum was found to increase whole-body and hepatic insulin sensitivity in mice...
October 2, 2017: Parasites & Vectors
Ryan E Wiegand, Pauline N M Mwinzi, Susan P Montgomery, YuYen L Chan, Kennedy Andiego, Martin Omedo, Geoffrey Muchiri, Michael O Ogutu, Fredrick Rawago, Maurice R Odiere, Diana M S Karanja, W Evan Secor
Background: Persistent hotspots have been described following mass drug administration (MDA) for the control of schistosomiasis, but have not been studied during the course of a multi-year MDA program. Methods: In data from a five-year study of school-based and village-wide preventive chemotherapy strategies for Schistosoma mansoni, spatial scan statistics were used to find infection hotspots in three populations: 5-8 year olds, 9-12 year olds, and adults. Negative binomial regression was used to analyze changes from baseline and ROC analyses were used to predict which villages would reach prevalence and intensity endpoints...
September 16, 2017: Journal of Infectious Diseases
Richard E Sanya, Edward Tumwesige, Alison M Elliott, Janet Seeley
BACKGROUND: Praziquantel-based mass treatment is the main approach to controlling schistosomiasis mansoni in endemic areas. Interventions such as provision and use of safe water, minimising contact with infested water, disposal of stool in latrines and snail control provide key avenues to break the transmission cycle and can sustain the benefits of mass treatment in the long term. Efforts are also being made to develop a schistosomiasis vaccine which, if effective, might reduce the incidence of re-infection after treatment...
October 2017: PLoS Neglected Tropical Diseases
M Bazongo, A S Ouédraogo, M Zida, G P Bonkoungou, E Ouangré, A Sanou, N R Doamba, N Zongo, Y E Sawadogo, S S Traore
Acute appendicitis is a frequent pathology with diverse causes. Although Burkina Faso is a tropical country with endemic schistosomiasis, bilharzial appendicitis remains rare. We report 4 cases of appendicitis due to schistosomiasis that we treated at the university hospital of Yalgado Ouédraogo to call attention to the need for routine review of appendectomy parts. Four male patients, aged 22, 26, 30, and 35 years old, were admitted for abdominal pains. Eosinophilia was observed in one case. The preoperative diagnosis was acute appendicitis in 2 cases and appendiceal peritonitis in 2 others...
August 1, 2017: Médecine et Santé Tropicales
Abeer A Elhenawy, Rehab H Ashour, Nairmen Nabih, Naglaa M Shalaby, Amr A El-Karef, Hala S Abou-El-Wafa
BACKGROUND AND OBJECTIVE: Tyrphostin "AG1024" is an insulin growth factor-1 receptor (IGF-1R) inhibitor that displayed an effect on the viability of larval and mature schistosomes in vitro. We sought to investigate the possible in vivo role of AG1024 as a potential new anti-Schistosoma drug against immature and adult stages of Schistosoma mansoni and its effect on the degree of hepatic fibrosis and insulin pathway. METHODS: The study included a control non-infected group and 5 groups of S...
September 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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