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https://www.readbyqxmd.com/read/28722637/schistosomiasis-in-european-travelers-and-migrants-analysis-of-14-years-tropnet-surveillance-data
#1
Tilman Lingscheid, Florian Kurth, Jan Clerinx, Stefania Marocco, Begoña Trevino, Mirjam Schunk, José Muñoz, Ida E Gjørup, Tomas Jelinek, Michel Develoux, Graham Fry, Thomas Jänisch, Matthias L Schmid, Olivier Bouchaud, Sabino Puente, Lorenzo Zammarchi, Kristine Mørch, Anders Björkman, Heli Siikamäki, Andreas Neumayr, Henrik Nielsen, Urban Hellgren, Malgorzata Paul, Guido Calleri, Pavel Kosina, Bjørn Myrvang, José M Ramos, Gudrun Just-Nübling, Anna Beltrame, José Saraiva da Cunha, Peter Kern, Laurence Rochat, August Stich, Peter Pongratz, Martin P Grobusch, Norbert Suttorp, Martin Witzenrath, Christoph Hatz, Thomas Zoller, TropNet Schistosomiasis Investigator Group
Schistosomiasis remains one of the most prevalent parasitic diseases worldwide and the infection is frequently found in travelers and migrants. The European Network for Tropical Medicine and Travel Health conducted a sentinel surveillance study on imported schistosomiasis between 1997 and 2010. This report summarizes epidemiological and clinical data from 1,465 cases of imported schistosomiasis. Direct pathogen detection and serology were the main diagnostic tools applied. Of these, 486 (33%) cases were identified among European travelers, 231 (16%) among long-term expatriates, and 748 (51%) among non-European immigrants...
May 30, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28719332/case-report-a-symptomatic-case-of-hymenolepis-diminuta-infection-in-an-urban-dwelling-adult-in-malaysia
#2
Arine Fadzlun Ahmad, Romano Ngui, Jaxinthe Ong, Farikha Sarip, Wan Hafiz Wan Ismail, Hasidah Omar, Zurainee Mohamed Nor, Amirah Amir, Yvonne A L Lim, Rohela Mahmud
A case of Hymenolepis diminuta infection in a 43-year-old Malaysian male with persistent abdominal colicky pain is reported. Endoscopy revealed whitish worms in the lumen of the small intestine, which were identified as H. diminuta after microscopy. Patient was successfully treated with a single dose of praziquantel (25 mg/kg).
July 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28689966/comparative-in-vitro-and-in-vivo-taste-assessment-of-liquid-praziquantel-formulations
#3
Magdalena Münster, Abeer H A Mohamed-Ahmed, Laura I Immohr, Corinna Schoch, Carsten Schmidt, Catherine Tuleu, Jörg Breitkreutz
The taste of pharmaceuticals strongly affects the compliance of patients. This study investigated the applicability of the electronic tongue and rodent brief-access taste aversion (BATA) model for the bitter compound praziquantel (PZQ) and taste masked liquid formulations for PZQ. In a comparative study maltodextrin (MD) Kleptose(®) linecaps 17 was selected as an alternative taste masking agent to two cyclodextrins; hydroxypropyl-beta-cyclodextrin (HP-β-CD) and sulfobutyl ether-beta-cyclodextrin (SBE-β-CD)...
July 8, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28686009/ferrocenyl-ruthenocenyl-and-benzyl-oxamniquine-derivatives-with-cross-species-activity-against-schistosoma-mansoni-and-schistosoma-haematobium
#4
Jeannine Hess, Gordana Panic, Malay Patra, Luciano Mastrobuoni, Bernhard Spingler, Saonli Roy, Jennifer Keiser, Gilles Gasser
Schistosomiasis is a parasitic disease that affects more than 250 million people annually, mostly children in poor, tropical, rural areas. Only one treatment (praziquantel) is available, putting control efforts at risk should resistance occur. In pursuit of treatment alternatives, we derivatized an old antischistosomal agent, oxamniquine (OXA). Four organometallic derivatives of OXA were synthesized and tested against Schistosoma mansoni in vitro and in vivo. Of these, a ferrocenyl derivative, 1, killed larval and adult worms 24 h postexposure in vitro, in contrast to OXA, which lacks in vitro activity against adult worms...
July 18, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/28666754/antiparasitic-activity-of-nerolidol-in-a-mouse-model-of-schistosomiasis
#5
Marcos P Silva, Rosimeire N de Oliveira, Ana C Mengarda, Daniel B Roquini, Silmara M Alegretti, Maria C Salvadori, Fernanda S Teixeira, Damião P de Sousa, Pedro L S Pinto, Josué de Moraes
Schistosomiasis is a major public health problem worldwide, especially in poor communities. Since praziquantel is currently the only drug available to treat schistosomiasis, there is an urgent need to identify new antischistosomal drugs. Nerolidol is a sesquiterpene present as an essential oil in several plants, and it has been approved by the US Food and Drug Administration. In this study, we evaluated the in vivo antischistosomal activity of nerolidol in a mouse model of schistosomiasis infected with either adult or juvenile stages of Schistosoma mansoni...
June 27, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28659195/development-and-testing-of-schisto-and-ladders%C3%A2-an-innovative-health-educational-game-for-control-of-schistosomiasis-in-schoolchildren
#6
Cynthia Uchechukwu Ejike, Akinola Stephen Oluwole, Hammed Oladeji Mogaji, Adebiyi Abdulhakeem Adeniran, Oladimeji Michael Alabi, Uwem Friday Ekpo
BACKGROUND: Schistosomiasis remains a public health problem in many regions of the world, including Nigeria. Current control strategy involves mass drug administration with praziquantel to the endemic population. To complement and sustain on-going preventive chemotherapy, we developed a health educational game named Schisto and Ladders™ and tested its potential for the control of schistosomiasis among schoolchildren living in Imala-Odo, a highly endemic community near Abeokuta, Nigeria...
June 28, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28655333/deworming-of-stray-dogs-and-wild-canines-with-praziquantel-laced-baits-delivered-by-an-unmanned-aerial-vehicle-in-areas-highly-endemic-for-echinococcosis-in-china
#7
Qing Yu, Ning Xiao, Shi-Jie Yang, Shuai Han
BACKGROUND: Canines, the definitive hosts for the parasites causing alveolar (AE) and cystic echinococcosis (CE), are the main source of this infections playing the key role in the transmission. The ten-year mortality rate of AE is extremely high (94%) if the patients are not given sustained treatment. The aim of this field study is to explore the possibility of delivery of praziquantel-laced baits using unmanned aerial vehicles (UAVs) aimed at deworming wild canines in the endemic areas...
June 27, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28652164/schistosoma-haematobium-a-delayed-cause-of-hematuria
#8
Wei Phin Tan, Thomas Hwang, Ji-Weon Park, Lev Elterman
A 22-year-old African-American man with recurrent episodes of gross hematuria for 6 months presented to the clinic for evaluation. A thorough history revealed that the patient emigrated from Mozambique to the United States 12 years ago. Urine culture was negative for a urinary tract infection. Cystoscopy revealed 4 lesions in the bladder. Biopsy of the bladder lesion revealed severe cystitis and Schistosoma Haematobium. The patient later confirmed that he used to swim in rivers and streams back in Africa. He completed a course of praziquantel and his gross hematuria resolved...
June 23, 2017: Urology
https://www.readbyqxmd.com/read/28651981/synthesis-and-anthelmintic-activity-of-arctigenin-derivatives-against-dactylogyrus-intermedius-in-goldfish
#9
Yang Hu, Lei Liu, Guang-Lu Liu, Xiao Tu, Gao-Xue Wang, Fei Ling
To control the parasitic disease of Dactylogyrus intermedius, a series of new arctigenin derivatives were designed, synthesized and tested in our study. The anthelmintic activity of most of the derivatives ranged from 1 to 10mg/L. Compared to traditional drug praziquantel (EC50=2.69mg/L), ether derivatives 2g and 2h exhibited slightly higher anti-parasitic activity, with the EC50 values of 2.48 and 1.52mg/L, respectively. Furthermore, the arctigenin-imidazole hybrids 4a and 4b also removed D. intermedius effectively, with the EC50 values of 2...
August 1, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28650976/effect-of-praziquantel-on-the-differential-expression-of-mouse-hepatic-genes-and-parasite-atp-binding-cassette-transporter-gene-family-members-during-schistosoma-mansoni-infection
#10
Melissa C Sanchez, Katina V Krasnec, Amalia S Parra, Christian von Cabanlong, Geoffrey N Gobert, Boris Umylny, Pauline M Cupit, Charles Cunningham
Schistosomiasis is a chronic parasitic disease caused by sexually dimorphic blood flukes of the genus Schistosoma. Praziquantel (PZQ) is the only drug widely available to treat the disease but does not kill juvenile parasites. Here we report the use of next generation sequencing to study the transcriptional effect of PZQ on murine hepatic inflammatory, immune and fibrotic responses to Schistosoma mansoni worms and eggs. An initial T helper cell 1 (Th1) response is induced against schistosomes in mice treated with drug vehicle (Vh) around the time egg laying begins, followed by a T helper cell 2 (Th2) response and the induction of genes whose action leads to granuloma formation and fibrosis...
June 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28640131/paragonimiasis-in-children-in-southwest-china-a-retrospective-case-reports-review-from-2005-to-2016
#11
Zongrong Gong, Ruixue Miao, Min Shu, Yu Zhu, Yang Wen, Qin Guo, Qiong Liao, Chaomin Wan
BACKGROUND: Paragonimiasis infection has no specific symptoms or typical radiologic findings, leading to the possibility of misdiagnosis. Thus, the objective of this study was to analyze clinical and radiological features, and treatment outcome of paragonimiasis in children in Southwest China to improve the awareness of this disease. METHODS: We retrospectively reviewed the records of children diagnosed with paragonimiasis in West China Second University Hospital between 2005 and 2016...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28637488/a-high-throughput-colorimetric-assay-for-detection-of-schistosoma-mansoni-viability-based-on-the-tetrazolium-salt-xtt
#12
Pedro Henrique Nascimento Aguiar, Núbia Monteiro Gonçalves Soares Fernandes, Carlos Leomar Zani, Marina Moraes Mourão
BACKGROUND: Schistosoma mansoni is a trematode parasite that causes schistosomiasis, one of the most prevalent neglected tropical diseases, leading to the loss of 2.6 million disability-adjusted life years. Praziquantel is the only drug available, and new drugs are required. The most common strategy in schistosomiasis drug discovery is the use of the schistosomula larval-stage for a pre-screen in drug sensitivity assays. However, assessing schistosomula viability by microscopy has always been a limitation to the throughput of such assays...
June 21, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28622767/praziquantel-decreases-fecundity-in-schistosoma-mansoni-adult-worms-that-survive-treatment-evidence-from-a-laboratory-life-history-trade-offs-selection-study
#13
Poppy H L Lamberton, Christina L Faust, Joanne P Webster
BACKGROUND: Mass drug administration of praziquantel is the World Health Organization's endorsed control strategy for schistosomiasis. A decade of annual treatments across sub-Saharan Africa has resulted in significant reductions of infection prevalence and intensity levels, although 'hotspots' remain. Repeated drug treatments place strong selective pressures on parasites, which may affect life-history traits that impact transmission dynamics. Understanding drug treatment responses and the evolution of such traits can help inform on how to minimise the risk of drug resistance developing, maximise sustainable control programme success, and improve diagnostic protocols...
June 16, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28619672/point-of-care-diagnosis-of-multiple-schistosome-parasites-species-specific-dna-detection-in-urine-by-loop-mediated-isothermal-amplification-lamp
#14
Nilanjan Lodh, Kei Mikita, Kwabena M Bosompem, William K Anyan, Joseph K Quartey, Joseph Otchere, Clive J Shiff
Schistosomes are easily transmitted and high chance of repeat infection, so if control strategies based on targeted mass drug administration (MDA) are to succeed it is essential to have a test that is sensitive, accurate and simple to use. It is known and regularly demonstrated that praziquantel does not always eliminate an infection so in spite of the successes of control programs a residual of the reservoir survives to re-infect snails. The issue of diagnostic sensitivity becomes more critical in the assessment of program effectiveness...
June 12, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28619227/efficacy-and-safety-of-praziquantel-in-preschool-aged-and-school-aged-children-infected-with-schistosoma-mansoni-a-randomised-controlled-parallel-group-dose-ranging-phase-2-trial
#15
Jean T Coulibaly, Gordana Panic, Kigbafori D Silué, Jana Kovač, Jan Hattendorf, Jennifer Keiser
BACKGROUND: Praziquantel has been the drug of choice for schistosomiasis control for more than 40 years, yet surprisingly, the optimal dose for children younger than 4 years is not known. We aimed to assess the efficacy and safety of escalating praziquantel dosages in preschool-aged children (PSAC). METHODS: We did a randomised controlled, parallel-group, single-blind, dose-ranging, phase 2 trial in PSAC (2-5 years) and school-aged children (SAC; aged 6-15 years) as a comparator group in southern Côte d'Ivoire...
July 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28615852/therapecutic-efficacy-of-the-leaf-extract-of-croton-joufra-roxb-against-experimental-cestodiasis-in-rats
#16
Shyamalima Gogoi, Arun K Yadav
The leaves of Croton joufra have been used as a traditional medicine in Assam (Northeast India) to treat the intestinal helminthic infections. The aim of this study was to establish the in vitro and in vivo anthelmintic efficacy of the leaf extract of this plant on Hymenolepis diminuta, a zoonotic tapeworm. The plant extract was also screened for its chemical constituents. The in vitro anthelmintic efficacy of the plant was evaluated by physical motility test on adult cestodes, following their exposure to 10, 20, 30 mg/ml concentrations of the crude leaf extract, while the in vivo effect was determined based on the eggs per gram (EPG) counts and worm recovery rates, using an experimentally induced model of H...
June 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28606189/therapeutic-efficacy-of-artemisia-absinthium-against-hymenolepis-nana-in-vitro-and-in-vivo-studies-in-comparison-with-the-anthelmintic-praziquantel
#17
E V N Beshay
Hymenolepis nana is a common intestinal tapeworm that affects humans. Drugs are available for the treatment of this infection, including praziquantel (PZQ), nitazoxanide and niclosamide. Although the drug of choice is praziquantel, due to its high cure rates, indicators of the development of PZQ resistance by different parasites have begun to appear over recent decades. Therefore, this study was a trial to find an alternative to PZQ by assessing the activity of the crude aqueous extract of the medicinal herb Artemisia absinthium against H...
June 13, 2017: Journal of Helminthology
https://www.readbyqxmd.com/read/28605969/control-of-hymenolepis-nana-infection-as-a-measure-to-improve-mouse-colony-welfare
#18
Alenka Dovč, Gordana Gregurić Gračner, Iztok Tomažič, Ksenija Vlahović, Marina Pavlak, Renata Lindtner Knific, Klemen Kralj, Mateja Stvarnik, Aleksandra Vergles Rataj
After cannibalism had appeared in the reproductive units of a white mouse colony, treatment against confirmed Hymenolepis nana, a tapeworm with zoonotic potential, was performed on 67 mice in the reproductive and nursery units. Faecal droppings were evaluated by flotation and sedimentation methods. The sedimentation method revealed a higher number of positive results before, during and after the treatment, but the flotation method yielded some additional positive cases. In the reproductive unit, H. nana eggs were confirmed in 50% of the tested mice by the flotation and in 70% by the sedimentation method...
June 2017: Acta Veterinaria Hungarica
https://www.readbyqxmd.com/read/28595676/evaluation-of-the-impact-of-2-years-of-a-dosing-intervention-on-canine-echinococcosis-in-the-alay-valley-kyrgyzstan
#19
F VAN Kesteren, A Mastin, P R Torgerson, Bermet Mytynova, P S Craig
Echinococcosis is a re-emerging zoonotic disease in Kyrgyzstan. In 2012, an echinococcosis control scheme was started that included dosing owned dogs in the Alay Valley, Kyrgyzstan with praziquantel. Control programmes require large investments of money and resources; as such it is important to evaluate how well these are meeting their targets. However, problems associated with echinococcosis control schemes include remoteness and semi-nomadic customs of affected communities, and lack of resources. These same problems apply to control scheme evaluations, and quick and easy assessment tools are highly desirable...
June 9, 2017: Parasitology
https://www.readbyqxmd.com/read/28575043/radiological-evolution-of-porcine-neurocysticercosis-after-combined-antiparasitic-treatment-with-praziquantel-and-albendazole
#20
Carla Cangalaya, Javier A Bustos, Juan Calcina, Ana Vargas-Calla, Javier Mamani, Diego Suarez, Gianfranco Arroyo, Armando E Gonzalez, Juan Chacaltana, Cristina Guerra-Giraldez, Siddhartha Mahanty, Theodore E Nash, Héctor H García
BACKGROUND: The onset of anthelmintic treatment of neurocysticercosis (NCC) provokes an acute immune response of the host, which in human cases is associated with exacerbation of neurological symptoms. This inflammation can occur at the first days of therapy. So, changes in the brain cysts appearance may be detected by medical imaging. We evaluated radiological changes in the appearance of brain cysts (enhancement and size) on days two and five after the onset of antiparasitic treatment using naturally infected pigs as a model for human NCC...
June 2017: PLoS Neglected Tropical Diseases
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