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Praziquantel

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https://www.readbyqxmd.com/read/28327807/ultrastructural-study-of-morphological-changes-in-schistosoma-mansoni-after-in-vitro-exposure-to-the-monoterpene-rotundifolone
#1
Thiago José Matos-Rocha, Marília Gabriela Dos Santos Cavalcanti, José Maria Barbosa-Filho, Ana Silvia Suassuna Carneiro Lúcio, Dyana Leal Veras, Márcia Ortiz Mayo Marques, Luiz Carlos Alves, Fábio André Brayner
INTRODUCTION: Schistosomiasis, a parasitic disease caused by trematode flatworms of the genus Schistosoma, affects more than 200 million people worldwide, and its control is dependent on a single drug, praziquantel. Here, we report the in vitro effect of rotundifolone, a monoterpene isolated from Mentha x villosa (Lamiaceae), on Schistosoma mansoni adult worms. METHODS: The in vitro effect of rotundifolone on adult Schistosoma mansoni was evaluated by analysis of behavior and mortality and through a scanning electron microscopic analysis of ultrastructural changes in the tegument of the worms...
January 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28327785/ultrastructural-alterations-in-schistosoma-mansoni-juvenile-and-adult-male-worms-after-in-vitro-incubation-with-primaquine
#2
Reem Osama A Kamel, Fatma El-Zahraa Anwar Bayaumy
BACKGROUND: Praziquantel has been cited as the only drug for treating schistosomiasis. However, concerns over drug resistance have encouraged the search for novel drug leads. The antimalarial drug primaquine possesses interesting anti-schistosmal properties. OBJECTIVES: This study is the first to document the potential role of primaquine as a schistosomicide and the ultrastructural changes induced by primaquine on juvenile or adult male worms of Schistosoma mansoni...
April 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28316404/senna-alexandrina-mill-induced-ultrastructural-changes-on-hymenolepis-diminuta
#3
S Kundu, S Roy, S Nandi, B Ukil, Larisha Mawkhlieng Lyndem
Senna alexandrina Mill. has been used for antimicrobial activity. In the present study, the crude ethanolic extract of the plant and a synthetic compound Sennoside were tested in vitro on Hymenolepis diminuta to evaluate its potential anthelmintic efficacy through ultrastructural changes. Worms were maintained between rat model and beetle and the test parasites were exposed to different concentrations of crude ethanolic leaf extracts of S. alexandrina. Praziquantel was used as a reference drug. Dose dependent efficacy was observed in terms of motility and time of mortality in all treated parasites...
March 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28285508/a-case-of-taenia-asiatica-infection-diagnosed-by-colonoscopy
#4
Heung Up Kim, Young-Bae Chung
A case of Taenia asiatica infection detected by small bowel series and colonoscopy is described. The patient was a 42-year-old Korean man accompanied by discharge of movable proglottids via anus. He used to eat raw pig liver but seldom ate beef. Small bowel series radiologic examinations showed flat tape-like filling defects on the ileum. By colonoscopy, a moving flat tapeworm was observed from the terminal ileum to the ascending colon. The tapeworm was identified as T. asiatica by mitochondrial DNA sequencing...
February 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/28285500/a-human-case-of-zoonotic-dog-tapeworm-dipylidium-caninum-eucestoda-dilepidiidae-in-china
#5
Peng Jiang, Xi Zhang, Ruo Dan Liu, Zhong Quan Wang, Jing Cui
We described a human case of zoonotic dog tapeworm, Dipylidium caninum (Eucestoda: Dilepidiidae), rarely occurring in China. The mother of a 17 month-old boy noted the appearance of small white and active worms over a month period in her son's feces, but the boy was asymptomatic except mild diarrhea. We observed 3 tapeworm proglottids resembling cucumber seeds in his stool sample. Microscopically, each proglottid had 2 genital pores, 1 on each lateral edge, and numerous egg capsules in the uterus. The patient was successfully treated with a single oral dose of praziquantel...
February 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/28275906/molecular-modeling-and-infrared-and-raman-spectroscopy-of-the-crystal-structure-of-the-chiral-antiparasitic-drug-praziquantel
#6
Ana Borrego-Sánchez, Alfonso Hernández-Laguna, C Ignacio Sainz-Díaz
Anthelmintic praziquantel (PZQ) and its molecular and crystal lattice structures were studied by means of atomistic calculations based on empirical interatomic potentials and quantum mechanical methods (DFT). This chiral drug presents several crystal polymorphs due to the enantiomers (either R or S) or the racemic crystal, and different molecular conformations. The relative configurations of the carbonyl groups in PZQ define these conformations that produce different polymorphs. The polarity of these conformers is quite different and their relative population can vary in media with different polarity...
April 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28264841/praziquantel-for-schistosomiasis-single-drug-revisited-metabolism-mode-of-action-and-resistance
#7
Nuno Vale, Maria João Gouveia, Gabriel Rinaldi, Paul J Brindley, Fátima Gärtner, José M C Correia da Costa
Schistosomiasis, a major neglected tropical disease, affects more than 250 million people worldwide. Treatment for schistosomiasis has relied on the anthelmintic drug praziquantel (PZQ) for more than a generation. PZQ is the drug of choice for treatment of schistosomiasis; it is effective against all major forms of schistosomiasis, although PZQ is less active against juvenile compared to mature parasites. A pyrazino-isoquinoline derivative, PZQ is not considered to be toxic and generally causes few or transient, mild side effects...
March 6, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28249767/strongyle-egg-reappearance-period-after-moxidectin-treatment-and-its-relationship-with-management-factors-in-uk-equine-populations
#8
Thomas Tzelos, Jessica S G Barbeito, Martin K Nielsen, Eric R Morgan, Jane E Hodgkinson, Jacqueline B Matthews
Parasitic nematodes, particularly cyathostomins, are ubiquitous in grazing horses world-wide. Considerable burdens of cyathostomin larvae can encyst in the large intestinal wall. The most recommended treatment against these pathogenic stages is moxidectin. Information is required on how effective moxidectin is against cyathostomin populations in different regions. The objectives here were to determine the efficacy of moxidectin treatment and estimate the strongyle egg reappearance period (ERP) after treatment in several equine populations, to confirm the type of strongyle nematodes present and to identify other (i...
February 21, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28245890/one-hundred-years-of-neglect-in-paediatric-schistosomiasis
#9
Amaya L Bustinduy, Stephen Wright, Elizabeth C Joekes, Narcis B Kabatereine, Jutta Reinhard-Rupp, Charles H King, J Russell Stothard
Early in the history of schistosomiasis research, children under 5 years of age were known to be infected. Although this problem was recognized over 100 years ago, insufficient action has been taken to address this issue. Under current policy, such infected children only receive their first antiparasitic treatment (praziquantel - PZQ) upon entry into primary school as current mass drug administration programmes typically target school-aged children. For many infected children, they will wait up to 6 years before receiving their first medication and significant schistosomiasis-related morbidity may have already established...
March 1, 2017: Parasitology
https://www.readbyqxmd.com/read/28245883/schistosomiasis-and-soil-transmitted-helminthiasis-in-rwanda-an-update-on-their-epidemiology-and-control
#10
REVIEW
Nadine Rujeni, Domenica Morona, Eugene Ruberanziza, Humphrey D Mazigo
Even though Rwanda lies within a region that has a high prevalence of schistosomiasis and soil-transmitted helminth (STH) infections, epidemiological information regarding these infections in the country remains scarce. The present review attempts to compile the available data on schistosomiasis and STHs, from 1940 to 2014, to provide an insight on the epidemiological profile of these infections. This information will, in turn, support the design and implementation of sustainable control measures. The available records indicate that only Schistosoma mansoni and all the major species of STHs are endemic in Rwanda...
March 1, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28237476/effects-of-albendazole-artesunate-praziquantel-and-miltefosine-on-opisthorchis-viverrini-cercariae-and-mature-metacercariae
#11
Phornphitcha Pechdee, Monticha Chaiyasaeng, Chanisala Sereewong, Jukkrid Chaiyos, Apiporn Suwannatrai, Sutee Wongmaneeprateep, Smarn Tesana
OBJECTIVE: To explore larvicidal effects of anthelmintic drugs on Opisthorchis viverrini (O. viverrini) for alternative approach to interrupting its cycle for developing a field-based control program. METHODS: The larvicidal activities of albendazole (Al), artesunate (Ar), praziquantel (Pzq) and miltefosine (Mf) on O. viverrini cercariae and mature metacercariae were investigated. Lethal concentrations (LC50 and LC95) of these drugs were determined. Mature metacercariae previously exposed to various concentrations of the drugs were administered to hamsters...
February 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28231243/product-development-programs-for-neglected-tropical-diseases-a-crucial-role-for-expert-meetings
#12
Leonie Hussaarts, Kim van der Weijde, Pierre Dome, Elly Kourany-Lefoll, Jutta Reinhard-Rupp, Remco de Vrueh
No abstract text is available yet for this article.
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28222334/a-quantification-method-for-determination-of-racemate-praziquantel-and-r-enantiomer-in-rat-plasma-for-comparison-of-their-pharmacokinetics
#13
COMPARATIVE STUDY
Danlu Zhang, Haina Wang, Jianbo Ji, Lei Nie, Dequn Sun
Praziquantel is the drug of first choice for the control and treatment of all forms of schistosomiasis. Praziquantel is administered as a racemate, including R-enantiomer and S-enantiomer. Among them, R-enantiomer has main contribution to schistosomicidal activity. In this study, a sensitive and rapid liquid chromatography with tandem mass spectrometry was established and validated to determine the concentration of racemate praziquantel and R-enantiomer in rat plasma after oral administration. Chromatographic separation was performed on an Agilent Zorbax SB-C18 column...
March 24, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28222149/ultrasonographic-evaluation-of-urinary-tract-morbidity-in-school-aged-and-preschool-aged-children-infected-with-schistosoma-haematobium-and-its-evolution-after-praziquantel-treatment-a-randomized-controlled-trial
#14
Beatrice Barda, Jean T Coulibaly, Christoph Hatz, Jennifer Keiser
BACKGROUND: Schistosoma haematobium infections are responsible for significant urinary tract (UT) complications. Schistosomiasis control programs aim to reduce morbidity, yet the extent of morbidity in preschool-aged children and the impact of treatment on morbidity reduction are not well studied. METHODOLOGY: Our study was embedded in a randomized, placebo-controlled, single-blind trial in Côte d'Ivoire, which evaluated the efficacy and safety of three doses (20, 40 and 60 mg/kg) of praziquantel in school-aged (SAC) and preschool-aged (PSAC) children infected with S...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28221678/validated-capillary-electrophoretic-method-for-the-enantiomeric-quality-control-of-r-praziquantel
#15
Zoltán-István Szabó, Réka Gál, Levente Szőcs, Róbert Ludmerczki, Daniela-Lucia Muntean, Béla Noszál, Gergő Tóth
The enantiomers of praziquantel, the drug of choice in schistosomiasis, were separated by electrokinetic chromatography with cyclodextrins. Nine anionic cyclodextrins were screened for their ability to discriminate between the uncharged enantiomers. Seven investigated selectors presented chiral interactions with the enantiomers, these cases being interpreted in terms of stability constants and complex mobilities. The best results were delivered by sulfated-β-cyclodextrin, where quasi-equal stability constants were accompanied by extreme selectivity values and was explained on the basis of highly different mobilities of the transient diastereomeric complexes...
February 21, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28219563/repeated-prosthetic-mitral-valve-thrombosis-in-fluke%C3%A2-infection-induced-hypereosinophilic-syndrome
#16
Yiran Zhang, Liang Ma
A 43-year-old female patient with mitral valve stenosis and hypereosinophilia on admission received mechanical mitral valve replacement. During the 2 years after the first surgery, the patient underwent two mitral valve revision operations for repeated prosthetic mitral valve thrombosis. During the 2-year period, the patient's absolute eosinophil count was found elevated repeatedly. Finally, fluke antibody detection revealed fluke infection and, after praziquantel treatment, a normal level of absolute eosinophil count has been maintained and recurrent thrombosis has not occurred for 18 months...
March 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28219412/moving-from-control-to-elimination-of-schistosomiasis-in-sub-saharan-africa-time-to-change-and-adapt-strategies
#17
REVIEW
Louis-Albert Tchuem Tchuenté, David Rollinson, J Russell Stothard, David Molyneux
Schistosomiasis is a water borne parasitic disease of global importance and with ongoing control the disease endemic landscape is changing. In sub-Saharan Africa, for example, the landscape is becoming ever more heterogeneous as there are several species of Schistosoma that respond in different ways to ongoing preventive chemotherapy and the inter-sectoral interventions currently applied. The major focus of preventive chemotherapy is delivery of praziquantel by mass drug administration to those shown to be, or presumed to be, at-risk of infection and disease...
February 20, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28216368/in-vitro-and-in-vivo-cysticidal-activity-of-extracts-and-isolated-flavanone-from-the-bark-of-prunus-serotina-a-bio-guided-study
#18
Francisca Palomares-Alonso, Irma Susana Rojas-Tomé, Guadalupe Palencia Hernández, María Adelina Jiménez-Arellanes, Martha Lydia Macías-Rubalcava, Angélica González-Maciel, Andrea Ramos-Morales, Rosalba Santiago-Reyes, Nelly Castro, Iliana González-Hernández, Yadira Rufino-González, Helgi Jung-Cook
Currently, neurocysticercosis treatment involves two drugs: albendazole and praziquantel; however, their efficacy is suboptimal and new cysticidal drugs are needed. The present paper reports the cysticidal activity of extracts of the bark from Prunus serotina against Taenia crassiceps cysts and the isolation and identification of the main components of the most active extract. Results showed that all extracts displayed in vitro cysticidal activity (EC50=17.9-88.5μg/mL), being the methanolic the most active and selective...
February 16, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28214126/pulmonary-nodules-in-african-migrants-caused-by-chronic-schistosomiasis
#19
REVIEW
Federico Gobbi, Dora Buonfrate, Andrea Angheben, Anna Beltrame, Matteo Bassetti, Luca Bertolaccini, Giuseppe Bogina, Simone Caia, Silvia Duranti, Maria Gobbo, Valentina Marchese, Stefania Marocco, Maria Merelli, Geraldo Monteiro, Alberto Terzi, Zeno Bisoffi
Schistosomiasis is a neglected tropical disease that can cause mainly hepatic and genitourinary damage, depending on the species. Involvement of the lungs has been commonly described in acute infection (Katayama syndrome) and chronic infection (pulmonary hypertension). Although rarely reported in the scientific literature, cases of lung nodules due to chronic schistosome infection are also possible and are probably more frequent than commonly thought. Here we report seven cases of African migrants who were diagnosed with chronic schistosomiasis and pulmonary nodules due to deposition of schistosome eggs, and we compare our findings to the case reports found in the scientific literature...
February 14, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28212414/decline-in-infection-related-morbidities-following-drug-mediated-reductions-in-the-intensity-of-schistosoma-infection-a-systematic-review-and-meta-analysis
#20
Gisele Andrade, David J Bertsch, Andrea Gazzinelli, Charles H King
BACKGROUND: Since 1984, WHO has endorsed drug treatment to reduce Schistosoma infection and its consequent morbidity. Cross-sectional studies suggest pre-treatment correlation between infection intensity and risk for Schistosoma-related pathology. However, evidence also suggests that post-treatment reduction in intensity may not reverse morbidity because some morbidities occur at all levels of infection, and some reflect permanent tissue damage. The aim of this project was to systematically review evidence on drug-based control of schistosomiasis and to develop a quantitative estimate of the impact of post-treatment reductions in infection intensity on prevalence of infection-associated morbidity...
February 2017: PLoS Neglected Tropical Diseases
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