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Praziquantel

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https://www.readbyqxmd.com/read/27905117/pharmacokinetics-of-new-high-concentration-and-long-acting-praziquantel-oily-suspensions-after-intramuscular-administration-in-cattle
#1
M Qian, L Wei, L Hao, S Tang
The aim of the study was to develop praziquantel (PZQ) oily suspensions with 30% PZQ high concentration for intramuscular injection and investigate their pharmacokinetics in cattle. Two optimized formulations containing 30% PZQ were developed in this study, and their quality met the technical standards set by the Ministry of Agriculture of the People's Republic of China. After intramuscular administrations of the suspensions (30 mg/kg), no significant differences were observed between the two oily suspensions...
December 1, 2016: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27903284/gp50-as-a-promising-early-diagnostic-antigen-for-taenia-multiceps-infection-in-goats-by-indirect-elisa
#2
Xing Huang, Jing Xu, Yu Wang, Cheng Guo, Lin Chen, Xiaobin Gu, Weimin Lai, Xuerong Peng, Guangyou Yang
BACKGROUND: Coenurosis is caused by coenurus, the metacestode of Taenia multiceps, which mainly parasitizes the brain and spinal cord of cattle, sheep and goats. To date, no widely-approved methods are available to identify early coenurus infection. METHODS: In this study, we identified a full-length cDNA that encodes GP50 (TmGP50) from the transcriptome of T. multiceps, and then cloned and expressed in E. coli. The native proteins in adult stage and coenurus were located via immunofluorescence assays, while the potential of recombinant TmGP50 protein (rTmGP50) for indirect ELISA-based serodiagnostics was assessed using native goat sera...
December 1, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27888125/initiating-ntd-programs-targeting-schistosomiasis-and-soil-transmitted-helminthiasis-in-two-provinces-of-the-democratic-republic-of-the-congo-establishment-of-baseline-prevalence-for-mass-drug-administration
#3
Achille Kabore, Moudachirou Ibikounle, Jean Jacques Tougoue, Sylvain Mupoyi, Martin Ndombe, Scott Shannon, Eric A Ottesen, Faustin Mukunda, Naomi Awaca
BACKGROUND: Schistosomiasis (SCH) and soil-transmitted helminthiasis (STH) are widely distributed in the Democratic Republic of the Congo (DRC) and constitute a serious public health problem. As recommended by the World Health Organization (WHO), before launching mass chemotherapy to control these diseases, parasitological surveys were conducted in sentinel sites in six health zones (HZs) in Bandundu and Maniema provinces. Baseline prevalence and intensity of infection for SCH and STH were determined to establish the appropriate treatment plan using Praziquantel (PZQ) and Albendazole (ALB)...
November 22, 2016: Acta Tropica
https://www.readbyqxmd.com/read/27884406/-clinical-approach-to-imported-eosinophilia
#4
Elías Cañas García-Otero, Julia Praena-Segovia, Maite Ruiz-Pérez de Pipaón, Xerach Bosh-Guerra, Magdalena Sánchez-Agüera, Daniel Álvarez-Martínez, José Miguel Cisneros-Herreros
Eosinophilia is a common finding in international travelers and immigrants, being an helmintic infection its main etiology. The positive predictive value of eosinophilia for an helmintosis is low in travellers. Eosinophilia may be an incidental finding, or symptomatic, and it represents a clinical challenge due to the low sensitivity and specificity of direct and indirect parasitological diagnostic tests, respectively. It requires a structured approach based on geographical areas, environmental exposures and behavioral risks, and associated symptoms...
December 2016: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/27879464/severe-pleuropulmonary-paragonimiasis-caused-by-paragonimus-mexicanus-treated-as-tuberculosis-in-ecuador
#5
Manuel Calvopina, Daniel Romero-Alvarez, Rubén Macias, Hiromu Sugiyama
A 30-year-old male, from a subtropical region of Ecuador, was hospitalized with a 5-year history of persistent cough with rusty brown sputum, chest pain, and progressive dyspnea. The patient underwent thoracic surgery 3 years ago for pleural effusion and subsequently received a 9-month regimen treatment of tuberculosis. However, there was no clinical resolution and symptoms became progressively worse. A chest radiograph and computerized tomography scan showed several small nodules in both lungs. Eggs of Paragonimus spp...
November 22, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27876962/diagnosis-and-therapeutic-management-of-dipylidium-caninum-in-dogs-a-case-report
#6
Vijesh Kumar Saini, Snehil Gupta, Arjun Kasondra, R L Rakesh, A Latchumikanthan
The present study is related to Dipylidium caninum infection in dogs. Three dogs about 1 year of age with the history of scooting behaviour and passing diarrhoeic stool containing white specks were presented before the clinicians. Physical examination of dogs revealed flea infestation and faecal examination revealed the presence of gravid segments, which were confirmed microscopically to be of cestode, D. caninum. Dogs were treated with Praziquantel@5 mg/kg body wt. orally. Dogs showed marked recovery post treatment...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27876941/toxocara-vitulorum-in-a-suckling-calf-a-case-study
#7
Rayies Ahmed, Z A Wani, I M Allaie, M S Bushra, H A Hussain
The present clinical case reports toxocariosis in a suckling calf and its management. One and a half month old crossbred Jersey calf was presented at a Veterinary Clinics, District Pulwama, Kashmir with a history of intermittent diarrhea, poor growth, weakness, moderate dehydration and anorexia. On inspection, the calf showed normal physiological parameters viz; body temperature, pulse rate and respiration rate. On faecal examination, eggs of Toxocara vitulorum were found. The animal was treated with 30 ml suspension of 1...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27876076/bladder-outlet-obstruction-a-rare-complication-of-the-neglected-schistosome-schistosoma-haematobium-two-case-reports-and-public-health-challenges
#8
Valirie Ndip Agbor, Tsi Njim, Franklin Ngu Mbolingong
BACKGROUND: Schistosomiasis is a severe parasitic infestation with debilitating complications and is the third most devastating tropical disease in the world. It is one of the neglected tropical diseases (NTDs) with a high disease-burden. We present two rare cases of bladder outlet obstruction: one which led to a chronic kidney disease and ultimately death and a second which recovered after treatment with praziquantel. CASE PRESENTATIONS: A 72 year old male presented with lower urinary tract symptoms which culminated in an episode of acute urinary retention...
November 22, 2016: BMC Research Notes
https://www.readbyqxmd.com/read/27856336/local-immune-response-to-primary-infection-and-re-infection-by-clonorchis-sinensis-in-fvb-mice
#9
Eun-Min Kim, Hak Sun Yu, Yan Jin, Min-Ho Choi, Young Mee Bae, Sung-Tae Hong
Although Clonorchis sinensis lives in the bile duct, few studies have investigated the local immune response in the liver and bile duct. To investigate the local immune response to C. sinensis, we investigated the activation and recruitment of various immune cells and cytokine levels in the liver and bile duct lymph nodes (BLN) in FVB mice after primary infection and re-infection. Male 4-week-old FVB mice were divided into 6 experimental groups: uninfected controls, primary infection lasting 1week (PI 1w), primary infection lasting 4weeks (PI 4w), praziquantel treatment after PI 4w (Tx), re-infection lasting 1week after Tx (RI 1w), and re-infection lasting 4weeks after Tx (RI 4w)...
November 14, 2016: Parasitology International
https://www.readbyqxmd.com/read/27849482/clinical-report-schistosomiasis-exposure-in-u-s-service-personnel-during-whitewater-rafting-on-the-nile-river-in-jinja-uganda
#10
Samuel Maluil, Rom A Stevens
Schistosomiasis is a known risk after exposure to freshwater in tropical parts of the world. In March 2014, 28 off-duty U.S. service members went on a water adventure in the Nile River in Jinja, Uganda. In April 2014, 10 of the 28 service members returned for a second water adventure. Twelve weeks after freshwater exposure, schistosomiasis enzyme-linked immunosorbent assay testing was performed. Twenty-five percent had elevated Schistosomiasis mansoni immunoglobulin G (7 positive of 28 exposed); all had negative pre-exposure serology...
November 2016: Military Medicine
https://www.readbyqxmd.com/read/27842865/monitoring-the-efficacy-of-drugs-for-neglected-tropical-diseases-controlled-by-preventive-chemotherapy
#11
REVIEW
M Albonico, B Levecke, P T LoVerde, A Montresor, R Prichard, J Vercruysse, J P Webster
In the last decade, pharmaceutical companies, governments and global health organisations under the leadership of the World Health Organization (WHO) have pledged large-scale donations of anthelmintic drugs, including ivermectin (IVM), praziquantel (PZQ), albendazole (ALB) and mebendazole (MEB). This worldwide scale-up in drug donations calls for strong monitoring systems to detect any changes in anthelmintic drug efficacy. This review reports on the outcome of the WHO Global Working Group on Monitoring of Neglected Tropical Diseases Drug Efficacy, which consists of three subgroups: (i) soil-transmitted helminthiases (ALB and MEB); (ii) onchocerciasis and lymphatic filariasis (IVM); and (iii) schistosomiasis (PZQ)...
December 2015: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/27836498/repositioning-of-chlorambucil-as-a-potential-anti-schistosomal-agent
#12
Maha M Eissa, Shereen F Mossallam, Eglal I Amer, Layla K Younis, Hoda A Rashed
As parasites and cancer cells share many lifestyle and behavioral resemblances, repositioning of anti-cancerous agents as anti-parasitic is quite trendy, especially those sharing the same therapeutic targets. Therefore, the current study investigated the in vitro efficacy of ascending concentrations of chlorambucil (0.5-20μg/ml) against adult Schistosoma mansoni worms, over 72h. Additionally, its in vivo effects against the different developmental stages of the worm were assessed, after an oral dose of 2.5mg/kg/day for five successive days, through evaluating the worm load reduction and worms' morphological alterations and oogram changes...
November 9, 2016: Acta Tropica
https://www.readbyqxmd.com/read/27825652/-disseminated-peritoneal-hydatidosis-manifested-as-intestinal-ischaemia
#13
Enrique Rosales-Castañeda, José Luis Martínez-Ordaz, Alicia Estrada-Castellanos, Luz María Goméz-Jiménez
BACKGROUND: The hydatid disease, or echinococcosis, is endemic in Mediterranean countries, as well as in Australia, Asia, Africa, South America, and Canada. Among its complications is intraperitoneal rupture, a rare form of presentation, with highly variable symptoms. The treatment of choice is surgery plus adjuvant medical treatment in most patients. OBJECTIVE: A case is presented of a patient with disseminated peritoneal hydatidosis manifested as intestinal ischaemia...
November 5, 2016: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/27816660/diagnosing-schistosomiasis-induced-liver-morbidity-implications-for-global-control
#14
David U Olveda, Marianette Inobaya, Remigio M Olveda, Marilyn L Vinluan, Shu-Kay Ng, Kosala Weerakoon, Donald P McManus, Grant A Ramm, Donald A Harn, Yuesheng Li, Alfred K Lam, Jerric R Guevarra, Allen G Ross
BACKGROUND: Subclinical morbidity due to schistosomiasis was evaluated in 565 patients, and the enhanced liver fibrosis (ELF) test was assessed for the first time as a potential screening tool for disease. METHODS: The prevalence and intensity of infection were determined by Kato-Katz thick smear stool examination at baseline and 2 years after curative treatment. The degree of hepatic fibrosis was assessed by ultrasound. Non-invasive serum biomarkers of hepatic fibrosis were also evaluated...
November 2, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27812902/long-term-effectiveness-of-the-integrated-schistosomiasis-control-strategy-with-emphasis-on-infectious-source-control-in-china-a-10-year-evaluation-from-2005-to-2014
#15
Xiaoli Wang, Wei Wang, Peng Wang
Schistosomiasis is a neglected tropical parasitic disease of great public health significance worldwide. Currently, mass drug administration with praziquantel remains the major strategy for global schistosomiasis control programs. Since 2005, an integrated strategy with emphasis on infectious source control was implemented for the control of schistosomiasis japonica, a major public health concern in China, and pilot studies have demonstrated that such a strategy is effective to reduce the prevalence of Schistosoma japonicum infection in both humans and bovines...
November 3, 2016: Parasitology Research
https://www.readbyqxmd.com/read/27808086/vascular-endothelial-growth-factor-promotes-the-activation-of-hepatic-stellate-cells-in-chronic-schistosomiasis
#16
Jie Luo, Yuejin Liang, Fanping Kong, Jingfan Qiu, Xinjian Liu, Ailing Chen, Bruce A Luxon, Hannah W Wu, Yong Wang
BACKGROUND: The activation of hepatic stellate cells (HSCs) is a key event in fibrotic pathogenesis. However, the mechanism involving activation of HSCs in chronic schistosomiasis is not entirely clear. METHODS: Human HSC LX-2 and human umbilical vein endothelial cells (ECs) were cultured with Schistosoma japonicum (S. japonicum) antigens (SA) in vitro. Fibrosis-associated genes and cell proliferation were analyzed. HSCs were isolated from mice of chronic schistosomiasis with or without praziquantel (PZQ) treatment, followed by the microarray analysis for the liver fibrosis-associated pathways...
November 3, 2016: Immunology and Cell Biology
https://www.readbyqxmd.com/read/27799503/a-case-report-of-schistosoma-haematobium-infection-in-a-pregnant-migrant-raises-concerns-about-lack-of-screening-policies
#17
Maria Mazzitelli, Giovanni Matera, Carmela Votino, Federica Visconti, Alessio Strazzulla, Maria Teresa Loria, Cinzia Peronace, Pio Settembre, Aida Giancotti, Maria Carla Liberto, Alfredo Focà, Fulvio Zullo, Carlo Torti
Pregnant women with urinary schistosomiasis should be treated, but screening is not implemented in migrants. We report herein a case of a migrant diagnosed late into pregnancy, after diagnosis was made in her husband. Praziquantel was safe and effective. Schistosomiasis should be considered in pregnant women from endemic countries.
July 2016: Journal of Travel Medicine
https://www.readbyqxmd.com/read/27790438/hymenolepis-diminuta-infection-in-a-school-going-child-first-case-report-from-uttarakhand
#18
Pratima Gupta, Priyanka Gupta, Bhanu Kiran Bhakri, Neelam Kaistha, Balram Ji Omar
Hymenolepis diminuta (H.diminuta) is prevalent worldwide, and a few hundred human cases have been reported till date. It is primarily a rodent parasite and humans (usually children) can act as accidental hosts. Infections are usually asymptomatic but abdominal pain, irritability, pruritis, mild diarrhoea and eosinophilia are among the existing symptoms in a few of the reported cases. Here, we report a case of an 11-year-old female child from Bijnor, who presented to us with complaints of abdominal pain, fatigue and irregular episodes of fever...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27787774/update-on-the-diagnosis-and-management-of-neurocysticercosis
#19
REVIEW
Camille M Webb, A Clinton White
Neurocysticercosis is an important cause of seizures worldwide and is endemic in most of Latin America, Sub-Saharan Africa, Southeast Asia, India, and China. Neurocysticercosis has profoundly different disease manifestations varying from asymptomatic presentation to life-threatening hydrocephalus. Clinical manifestations, pathogenesis, diagnostic methods, and optimal treatment vary with the location, number of lesions, and host response. Diagnosis is based on a combination of clinical presentation, neuroimaging findings, history of exposure, and serologic testing...
December 2016: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/27786158/praziquantel-delivery-via-moist-pellets-to-treat-monogenean-parasites-of-yellowtail-kingfish-seriola-lalandi-efficacy-and-feed-acceptance
#20
James M Forwood, Erin J Bubner, Matt Landos, Marty R Deveney, Trent D'Antignana
Praziquantel (PZQ) is registered for oral use against Benedenia seriolae infecting Seriola spp. in Japan, but its bitter taste causes poor palatability. Incorporating PZQ in a moist pellet may help mask the flavor to improve intake. Altering delivery, however, may influence efficacy. We assessed the minimum effective concentrations of PZQ in moist pellets delivered by intubation for the monogeneans Zeuxapta seriolae and B. seriolae infecting yellowtail kingfish Seriola lalandi in flow-through tanks. The optimised dose was then evaluated in a sea-cage of S...
October 27, 2016: Diseases of Aquatic Organisms
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