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https://www.readbyqxmd.com/read/28412409/development-of-monoclonal-antibodies-against-sj29-and-its-possible-application-for-schistosomiasis-diagnosis
#1
Cui-Ping Ren, Quan Liu, Feng-Chun Liu, Feng-Yu Zhu, Shi-Xiang Cui, Zhen Liu, Wen-Da Gao, Miao Liu, Yong-Sheng Ji, Ji-Jia Shen
OBJECTIVE: Timely Schistosoma japonicum detection improves outcomes in schistosomiasis. Here, we established a double antibody sandwich ELISA to detect Schistosoma japonicum. METHODS: Sj29 polyclonal and monoclonal antibodies were developed and identified. A Sj29 double antibody sandwich ELISA was evaluated. RESULTS: Assay sensitivity for detecting Schistosoma japonicum circulating antigen Sj29 was 76.7% (23/30), 54.5% (18/33) and 50.0% (18/36) in patients with acute, chronic and advanced schistosomiasis...
April 12, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28410369/quantitative-assessment-of-the-impact-of-partially-protective-anti-schistosomiasis-vaccines
#2
Ramzi A Alsallaq, David Gurarie, Martial Ndeffo Mbah, Alison Galvani, Charles King
BACKGROUND: Mass drug administration (MDA) of praziquantel has been the intervention of choice against schistosomiasis but with limited success in interrupting the transmission. The development of anti-Schistosoma vaccines is underway. Our objective is to quantify the population-level impact of anti-Schistosoma vaccines when administered alone and in combination with mass drug administration (MDA) and determine factors in vaccine design and public health implementation that optimize vaccination role in schistosomiasis control and elimination...
April 14, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28408356/possible-antifibrotic-effect-of-gdc-0449-vismodegib-a-hedgehog-pathway-inhibitor-in-mice-model-of-schistosoma-induced-liver-fibrosis
#3
Abeer A Elhenawy, Rehab H Ashour, Nairmen Nabih, Naglaa M Shalaby, Nirmeen Megahed
Liver fibrosis is a pathological process complicating schistosomiasis. It is an active process of continuous extracellular matrix accumulation. In Egypt, schistosomiasis re-infection is a continuing problem especially in rural areas. In this study we examined the antifibrotic effect of GDC-0449 (Vismodegib), a hedgehog-pathway inhibitor as a new molecular target for Schistosoma-induced liver fibrosis, in addition to exploring its effect as antischistosomal drug. The effect of GDC-0449 alone or combined with Praziquantel was tried experimentally in infected mice with Schistosoma mansoni...
April 10, 2017: Parasitology International
https://www.readbyqxmd.com/read/28406899/histone-deacetylase-inhibition-modulates-histone-acetylation-at-gene-promoter-regions-and-affects-genome-wide-gene-transcription-in-schistosoma-mansoni
#4
Letícia Anderson, Monete Rajão Gomes, Lucas Ferreira daSilva, Adriana da Silva Andrade Pereira, Marina M Mourão, Christophe Romier, Raymond Pierce, Sergio Verjovski-Almeida
BACKGROUND: Schistosomiasis is a parasitic disease infecting hundreds of millions of people worldwide. Treatment depends on a single drug, praziquantel, which kills the Schistosoma spp parasite only at the adult stage. HDAC inhibitors (HDACi) such as Trichostatin A (TSA) induce parasite mortality in vitro (schistosomula and adult worms), however the downstream effects of histone hyperacetylation on the parasite are not known. METHODOLOGY/PRINCIPAL FINDINGS: TSA treatment of adult worms in vitro increased histone acetylation at H3K9ac and H3K14ac, which are transcription activation marks, not affecting the unrelated transcription repression mark H3K27me3...
April 13, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28388940/putting-the-treatment-of-paediatric-schistosomiasis-into-context
#5
REVIEW
Takafira Mduluza, Francisca Mutapi
Despite increased international efforts to control schistosomiasis using preventive chemotherapy, several challenges still exist in reaching the target populations. Until recently, preschool-aged children had been excluded from the recommended target population for mass drug administration, i.e. primary school children aged 6-15 years. Our studies and those of others provided the evidence base for the need to treat preschool-aged children that led to recommendations by the World Health Organization to include preschool-aged children in treatment programmes in 2010...
April 7, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28385163/interruption-of-schistosomiasis-transmission-in-mountainous-and-hilly-regions-with-an-integrated-strategy-a-longitudinal-case-study-in-sichuan-china
#6
Yang Liu, Bo Zhong, Zi-Song Wu, Song Liang, Dong-Chuan Qiu, Xiao Ma
BACKGROUND: Schistosomiasis remains a major public health concern in China. Since 2004, an integrated strategy was developed to control the transmission of Schistosoma japonicum in China. However, the long-term effectiveness of this integrated strategy for the interruption of schistosomiasis transmission remains unknown in the mountainous and hilly regions of China until now. This longitudinal study aims to evaluate the effectiveness of the integrated strategy on transmission interruption of schistosomiasis in Sichuan Province from 2005 through 2014...
April 7, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28385154/efficacy-of-praziquantel-on-schistosoma-haematobium-and-re-infection-rates-among-school-going-children-in-the-ndumo-area-of-umkhanyakude-district-kwazulu-natal-south-africa
#7
Muhubiri Kabuyaya, Moses John Chimbari, Tawanda Manyangadze, Samson Mukaratirwa
BACKGROUND: Despite its low cure rates and possible resistance, praziquantel (PZQ) is the only drug available for schistosomiasis treatment. Hence, monitoring its efficacy is crucial. This study assessed the efficacy of PZQ, determined re-infection and incidence rates of Schistosoma haematobium infection among school-going children in the Ndumo area, KwaZulu-Natal. METHODS: A cohort of 320 school-going children (10 - 15 years) in 10 primary schools was screened for S...
April 7, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28382181/br%C3%A3-nsted-acid-mediated-cyclization-dehydrosulfonylation-reduction-sequences-an-easy-access-to-pyrazinoisoquinolines-and-pyridopyrazines
#8
Ramana Sreenivasa Rao, Chinnasamy Ramaraj Ramanathan
An efficient and alternative synthetic approach has been developed to prepare various N-(arylethyl)piperazine-2,6-diones from 4-benzenesulfonyliminodiacetic acid and primary amines using carbonyldiimidazole in the presence of a catalytic amount of DMAP at ambient temperature. Piperazine-2,6-diones are successfully transformed to pharmaceutically useful pyridopyrazines or pyrazinoisoquinolines and ene-diamides via an imide carbonyl group activation strategy using a Brønsted acid. Subsequent dehydrosulfonylation reactions of the ene-diamides, in a one pot manner, smoothly transformed them to substituted pyrazinones...
2017: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28380119/synthesis-and-biological-evaluation-of-novel-imidazolidine-derivatives-as-candidates-to-schistosomicidal-agents
#9
Thiago José Matos-Rocha, Maria do Carmo Alves de Lima, Anekécia Lauro da Silva, Jamerson Ferreira de Oliveira, Allana Lemos Andrade Gouveia, Vinícius Barros Ribeiro da Silva, Antônio Sérgio Alves de Almeida, Fábio André Brayner, Pablo Ramon Gualberto Cardoso, Marina da Rocha Pitta-Galdino, Ivan da Rocha Pitta, Moacyr Jesus Barreto de Melo Rêgo, Luiz Carlos Alves, Maira Galdino da Rocha Pitta
Introduction: Schistosomiasis is an infectious parasitic disease caused by trematodes of the genus Schistosoma, which threatens at least 258 million people worldwide and its control is dependent on a single drug, praziquantel. The aim of this study was to evaluate the anti-Schistosoma mansoni activity in vitro of novel imidazolidine derivatives. Material and methods: We synthesized two novel imidazolidine derivatives: (LPSF/PTS10) (Z)-1-(2-chloro-6-fluorobenzyl)-4-(4-dimethylaminobenzylidene)-5-thioxoimidazolidin-2-one and (LPSF/PTS23) (Z)-1-(2-chloro-6-fluoro-benzyl)-5-thioxo-4-(2,4,6-trimethoxy-benzylidene)-imidazolidin-2-one...
April 3, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28376858/clinical-diagnostic-value-of-viable-schistosoma-japonicum-eggs-detected-in-host-tissues
#10
Kongzhen Gu, Yuesheng Li, Patrick Driguez, Qingren Zeng, Xinlin Yu, Hui Sun, Liting Cai, Yongkang He, Wenyang Wang, Donald P McManus
BACKGROUND: Schistosomiasis, one of the neglected tropical diseases, is endemic in more than 70 countries. However, the clinical diagnosis of patients with a low degree of infection is an unsolved technical problem. In areas endemic for schistosomiasis japonica, proctoscopy detection of eggs has been one method used for clinical diagnosis. However, it is often a challenge to find typical live eggs and it is difficult to distinguish live eggs from large numbers of partially degraded and/or completely degraded eggs within colon biopsy tissue...
April 4, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28369090/rapid-mapping-of-urinary-schistosomiasis-an-appraisal-of-the-diagnostic-efficacy-of-some-questionnaire-based-indices-among-high-school-students-in-katsina-state-northwestern-nigeria
#11
Tolulope Ebenezer Atalabi, Taiwo Oluwakemi Adubi, Umar Lawal
BACKGROUND: In sub-Saharan Africa, over 200 million individuals are estimated to be infected with urinary and intestinal schistosomiasis. In a bid to lay a foundation for effective future control programme, this study was carried out with the aim of assessing the diagnostic efficacy of some questionnaire-based rapid assessment indices of urinary schistosomiasis. METHODOLOGY: A total number of 1,363 subjects were enrolled for the study. Questionnaires were administered basically in English and Hausa languages by trained personnel...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28363040/treatment-of-pulmonicola-cochleotrema-infection-with-ivermectin-praziquantel-combination-in-an-antillean-manatee-trichechus-manatus-manatus
#12
João Carlos Gomes Borges, Larissa Molinari Jung, Sebastião Silva Dos Santos, Vitor Luz Carvalho, Rafael Antonio Nascimento Ramos, Leucio Câmara Alves
The aim of this study was to report the use of an oral combination of ivermectin plus praziquantel in the treatment of a Pulmonicola cochleotrema in an Antillean manatee ( Trichechus manatus manatus). A female manatee was found exhibiting respiratory changes and the presence of parasites in the nares. Based on clinical manifestations presented by the manatee, a symptomatic therapeutic protocol was employed, which included an anthelmintic treatment using a combination of ivermectin plus praziquantel. The parasites retrieved were identified as P...
March 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28351414/controlling-schistosomiasis-with-praziquantel-how-much-longer-without-a-viable-alternative
#13
REVIEW
Robert Bergquist, Jürg Utzinger, Jennifer Keiser
The current approach of morbidity control of schistosomiasis, a helminth disease of poverty with considerable public health and socioeconomic impact, is based on preventive chemotherapy with praziquantel. There is a pressing need for new drugs against this disease whose control entirely depends on this single drug that has been widely used over the past 40 years. We argue that a broader anthelminthic approach supplementing praziquantel with new antischistosomals targeting different parasite development stages would not only increase efficacy but also reduce the risk for drug resistance...
March 28, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28348881/in-vitro-assessment-of-anthelmintic-activities-of-rauwolfia-vomitoria-apocynaceae-stem-bark-and-roots-against-parasitic-stages-of-schistosoma-mansoni-and-cytotoxic-study
#14
Emmanuel Mouafo Tekwu, Kwabena Mante Bosompem, William Kofi Anyan, Regina Appiah-Opong, Kofi Baffour-Awuah Owusu, Mabel Deladem Tettey, Felicia Amanfo Kissi, Alfred Ampomah Appiah, Veronique Penlap Beng, Alexander Kwadwo Nyarko
Schistosomiasis is a Neglected Tropical Diseases which can be prevented with mass deworming chemotherapy. The reliance on a single drug, praziquantel, is a motivation for the search of novel antischistosomal compounds. This study investigated the anthelmintic activity of the stem bark and roots of Rauwolfia vomitoria against two life stages of Schistosoma mansoni. Both plant parts were found to be active against cercariae and adult worms. Within 2 h of exposure all cercariae were killed at a concentration range of 62...
2017: Journal of Parasitology Research
https://www.readbyqxmd.com/read/28347672/structural-and-kinetic-analysis-of-schistosoma-mansoni-adenylosuccinate-lyase-smadsl
#15
Larissa Romanello, Vitor Hugo Balasco Serrão, Juliana Roberta Torini, Louise E Bird, Joanne E Nettleship, Heather Rada, Yamini Reddivari, Ray J Owens, Ricardo DeMarco, José Brandão-Neto, Humberto D'Muniz Pereira
Schistosoma mansoni is the parasite responsible for schistosomiasis, a disease that affects about 218 million people worldwide. Currently, both direct treatment and disease control initiatives rely on chemotherapy using a single drug, praziquantel. Concerns over the possibility of resistance developing to praziquantel, have stimulated efforts to develop new drugs for the treatment of schistosomiasis. Schistosomes do not have the de novo purine biosynthetic pathway, and instead depend entirely on the purine salvage pathway to supply its need for purines...
March 25, 2017: Molecular and Biochemical Parasitology
https://www.readbyqxmd.com/read/28327807/ultrastructural-study-of-morphological-changes-in-schistosoma-mansoni-after-in-vitro-exposure-to-the-monoterpene-rotundifolone
#16
Thiago José Matos-Rocha, Marília Gabriela Dos Santos Cavalcanti, José Maria Barbosa-Filho, Ana Silvia Suassuna Carneiro Lúcio, Dyana Leal Veras, Márcia Ortiz Mayo Marques, Luiz Carlos Alves, Fábio André Brayner
INTRODUCTION: Schistosomiasis, a parasitic disease caused by trematode flatworms of the genus Schistosoma, affects more than 200 million people worldwide, and its control is dependent on a single drug, praziquantel. Here, we report the in vitro effect of rotundifolone, a monoterpene isolated from Mentha x villosa (Lamiaceae), on Schistosoma mansoni adult worms. METHODS: The in vitro effect of rotundifolone on adult Schistosoma mansoni was evaluated by analysis of behavior and mortality and through a scanning electron microscopic analysis of ultrastructural changes in the tegument of the worms...
January 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28327785/ultrastructural-alterations-in-schistosoma-mansoni-juvenile-and-adult-male-worms-after-in-vitro-incubation-with-primaquine
#17
Reem Osama A Kamel, Fatma El-Zahraa Anwar Bayaumy
BACKGROUND: Praziquantel has been cited as the only drug for treating schistosomiasis. However, concerns over drug resistance have encouraged the search for novel drug leads. The antimalarial drug primaquine possesses interesting anti-schistosmal properties. OBJECTIVES: This study is the first to document the potential role of primaquine as a schistosomicide and the ultrastructural changes induced by primaquine on juvenile or adult male worms of Schistosoma mansoni...
April 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28316404/senna-alexandrina-mill-induced-ultrastructural-changes-on-hymenolepis-diminuta
#18
S Kundu, S Roy, S Nandi, B Ukil, Larisha Mawkhlieng Lyndem
Senna alexandrina Mill. has been used for antimicrobial activity. In the present study, the crude ethanolic extract of the plant and a synthetic compound Sennoside were tested in vitro on Hymenolepis diminuta to evaluate its potential anthelmintic efficacy through ultrastructural changes. Worms were maintained between rat model and beetle and the test parasites were exposed to different concentrations of crude ethanolic leaf extracts of S. alexandrina. Praziquantel was used as a reference drug. Dose dependent efficacy was observed in terms of motility and time of mortality in all treated parasites...
March 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28285508/a-case-of-taenia-asiatica-infection-diagnosed-by-colonoscopy
#19
Heung Up Kim, Young-Bae Chung
A case of Taenia asiatica infection detected by small bowel series and colonoscopy is described. The patient was a 42-year-old Korean man accompanied by discharge of movable proglottids via anus. He used to eat raw pig liver but seldom ate beef. Small bowel series radiologic examinations showed flat tape-like filling defects on the ileum. By colonoscopy, a moving flat tapeworm was observed from the terminal ileum to the ascending colon. The tapeworm was identified as T. asiatica by mitochondrial DNA sequencing...
February 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/28285500/a-human-case-of-zoonotic-dog-tapeworm-dipylidium-caninum-eucestoda-dilepidiidae-in-china
#20
Peng Jiang, Xi Zhang, Ruo Dan Liu, Zhong Quan Wang, Jing Cui
We described a human case of zoonotic dog tapeworm, Dipylidium caninum (Eucestoda: Dilepidiidae), rarely occurring in China. The mother of a 17 month-old boy noted the appearance of small white and active worms over a month period in her son's feces, but the boy was asymptomatic except mild diarrhea. We observed 3 tapeworm proglottids resembling cucumber seeds in his stool sample. Microscopically, each proglottid had 2 genital pores, 1 on each lateral edge, and numerous egg capsules in the uterus. The patient was successfully treated with a single oral dose of praziquantel...
February 2017: Korean Journal of Parasitology
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