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https://www.readbyqxmd.com/read/28542175/single-sex-infection-with-female-schistosoma-mansoni-cercariae-mitigates-hepatic-fibrosis-after-secondary-infection
#1
Nicole Koslowski, Martina Sombetzki, Micha Loebermann, Robby Engelmann, Niels Grabow, Christoph H Österreicher, Michael Trauner, Brigitte Mueller-Hilke, Emil C Reisinger
BACKGROUND: Infection with Schistosoma spp. affects more than 258 million people worldwide. Current treatment strategies are mainly based on the anthelmintic Praziquantel, which is effective against adult worms but neither prevents re-infection nor cures severe liver damage. The best long-term strategy to control schistosomiasis may be to develop an immunization. Therefore, we designed a two-step Schistosoma mansoni infection model to study the immune-stimulating effect of a primary infection with either male or female cercariae, measured on the basis of TH1/TH2-response, granuloma size and hepatic fibrosis after a secondary bisexual S...
May 19, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28537782/a-field-study-on-the-anthelmintic-resistance-of-parascaris-spp-in-arab-foals-in-riyadh-region-saudi-arabia
#2
Abdullah D Alanazi, Rami M Mukbel, Mohamed S Alyousif, Zafer S Al Shehri, Ibrahim O Alanazi, Hamdan I Al-Mohammed
BACKGROUND: In the last decade, Parascaris spp. resistance to anthelmintics has been recorded in many countries. In Saudi Arabia, there are limited data available on Parascaris spp. resistance to anthelmintics. OBJECTIVE: To determine the current status of ivermectin, abamectin and praziquantel combined, and fenbendazole resistance to Parascaris spp. in horses in Saudi Arabia. METHODS: Three hundred and forty one foals from eleven different farms were examined by faecal egg count (FEC)...
May 24, 2017: Veterinary Quarterly
https://www.readbyqxmd.com/read/28527633/anthelmintic-activity-of-cytochrome-p450-inhibitors-miconazole-and-clotrimazole-in-vitro-effect-on-the-liver-fluke-opisthorchis-felineus
#3
Viatcheslav A Mordvinov, Alexander G Shilov, Maria Y Pakharukova
Discovery of drugs for the treatment of opisthorchiasis and schistosomiasis is a high priority. The basic metabolic cytochrome P450 (CYP) system in parasitic flatworms contains a single gene. CYP of the liver fluke Opisthorchis felineus, the causative agent of opisthorchiasis, is important for survival of the worm, so may be a promising target for therapeutics against liver fluke infection. The aims of this study were: (i) to analyse in-vitro anthelmintic activity of various CYP inhibitors using standard motility and mortality assays against juvenile and adult O...
May 17, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28526608/microrna-analysis-of-taenia-crassiceps-cysticerci-under-praziquantel-treatment-and-genome-wide-identification-of-taenia-solium-mirnas
#4
Matías Gastón Pérez, Natalia Macchiaroli, Gabriel Lichtenstein, Gabriela Conti, Sebastián Asurmendi, Diego Humberto Milone, Georgina Stegmayer, Laura Kamenetzky, Marcela Cucher, Mara Cecilia Rosenzvit
MicroRNAs (miRNAs) are small non-coding RNAs that have emerged as important regulators of gene expression and perform critical functions in development and disease. In spite of the increased interest in miRNAs from helminth parasites, no information is available on miRNAs from Taenia solium, the causative agent of cysticercosis, a neglected disease affecting millions of people worldwide. Here we performed a comprehensive analysis of miRNAs from Taenia crassiceps, a laboratory model for T. solium studies, and identified miRNAs in the T...
May 17, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28520724/development-of-a-movement-based-in-vitro-screening-assay-for-the-identification-of-new-anti-cestodal-compounds
#5
Dominic Ritler, Reto Rufener, Heinz Sager, Jacques Bouvier, Andrew Hemphill, Britta Lundström-Stadelmann
Intestinal cestodes are infecting millions of people and livestock worldwide, but treatment is mainly based on one drug: praziquantel. The identification of new anti-cestodal compounds is hampered by the lack of suitable screening assays. It is difficult, or even impossible, to evaluate drugs against adult cestodes in vitro due to the fact that these parasites cannot be cultured in microwell plates, and adult and larval stages in most cases represent different organisms in terms of size, morphology, and metabolic requirements...
May 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28511056/elimination-of-schistosoma-mansoni-in-infected-mice-by-slow-release-of-artemisone
#6
Daniel Gold, Mohammed Alian, Avraham Domb, Yara Karawani, Maysa Jbarien, Jacques Chollet, Richard K Haynes, Ho Ning Wong, Viola Buchholz, Andreas Greiner, Jacob Golenser
The current treatment of schistosomiasis is based on the anti-helminthic drug praziquantel (PZQ). PZQ affects only the adult stages of schistosomes. In addition, resistance to PZQ is emerging. We suggest a drug, which could serve as a potential alternative or complement to PZQ, and as a means of treating infections at earlier, pre-granuloma stage. Derivatives of the peroxidic antimalarial drug artemisinin have been indicated as alternatives, because both plasmodia and schistosomes are blood-feeding parasites...
May 4, 2017: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/28495384/medicinal-chemistry-of-antischistosomal-drugs-praziquantel-and-oxamniquine
#7
REVIEW
Vinícius Barros Ribeiro da Silva, Bruna Rafaella Koresch Leiva Campos, Jamerson Ferreira de Oliveira, Jean-Luc Decout, Maria do Carmo Alves de Lima
Neglected tropical diseases (NTDs) are a group of diseases that, besides prevailing in poverty conditions, contribute to the maintenance of social inequality, being a strong barrier to a country development. Schistosomiasis, a NTD, is a tropical and subtropical disease caused by the trematode Schistosoma mansoni (Africa, Middle East, Caribbean, Brazil, Venezuela, Suriname), japonicum (China, Indonesia, the Philippines), mekongi (several districts of Cambodia and the Lao People's Democratic Republic), intercalatum and guianensis (areas of tropical rainforests in Central Africa) and hematobium (Middle East Africa, Corsica, France) whose adult forms inhabit the mesenteric vessels of the host, while the intermediate forms are found in the aquatic gastropod snails of the genus Biomphalaria...
April 27, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28495196/pharmacokinetics-of-a-novel-spot-on-formulation-of-praziquantel-for-dogs
#8
María Laura Gutiérrez, Guillermo Di Federico, Jorge A Dale, Juan M Minoia, Carlos D Corrales, Paula Schaiquevich, Silvia Wikinski
Praziquantel (PZQ) is an anthelmintic drug used both in humans and animals that can be administered through various routes. There are transdermal formulations for cats, but only oral or subcutaneous dosage forms for dogs. Given the fact that the cat's skin and the dog's skin have different characteristics, which in turn affect bioavailability, we developed a PZQ spot-on formulation for dogs. This study was aimed at determining the plasmatic behavior of topically administered PZQ (Labyes(®)) in adult dogs. Dogs were administered PZQ (14...
May 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28483578/mhc-ii-but-not-mhc-ii-hepatic-stellate-cells-contribute-to-liver-fibrosis-of-mice-in-infection-with-schistosoma-japonicum
#9
Chun-Lei Zhou, De-Long Kong, Jin-Feng Liu, Zhong-Kui Lu, Hong-Fei Guo, Wei Wang, Jing-Fan Qiu, Xin-Jian Liu, Yong Wang
Hepatic stellate cells (HSCs) are considered as the main effector cells in vitamin A metabolism and liver fibrosis, as well as in hepatic immune regulation. Recently, researches have revealed that HSCs have plasticity and heterogeneity, which depend on their lobular location and whether liver is normal or injured. This research aimed to explore the biological characteristics and heterogeneity of HSCs in mice with Schistosoma japonicum (S. japonicum) infection, and determine the subpopulation of HSCs in pathogenesis of hepatic fibrosis caused by S...
May 5, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28468685/a-neglected-risk-for-sparganosis-eating-live-tadpoles-in-central-china
#10
Jing Cui, Ye Wang, Xi Zhang, Xi-Meng Lin, Hong-Wei Zhang, Zhong-Quan Wang, Jia-Xu Chen
A 29-year-old farmer from central China was sent into the Emergency Department of the Affiliated Hospital of Zhengzhou University. He had a 15-day history of persistent high fever, abdominal distention and pain. The patient was clinically diagnosed as appendicitis and peritonitis, and treated with antibiotics in a local hospital, did not improve. On exploratory laparotomy, the appendicular perforation and peritonitis were seen; appendicectomy were performed, and antibiotics were given. However, high fever and abdominal pain still persisted; intestinal adhesion and obstruction, ascites appeared...
May 4, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28468637/drug-transporter-mediated-interactions-between-anthelminthic-and-antiretroviral-drugs-across-the-caco-2-cell-monolayers
#11
Gabriel Kigen, Geoffrey Edwards
BACKGROUND: Drug interactions between antiretroviral drugs (ARVs) and anthelminthic drugs, ivermectin (IVM) and praziquantel (PZQ) were assessed by investigating their permeation through the Caco-2 cell monolayers in a transwell. The impact of anthelminthics on the transport of ARVs was determined by assessing the apical to basolateral (AP → BL) [passive] and basolateral to apical (BL → AP) [efflux] directions alone, and in presence of an anthelminthic. The reverse was conducted for the assessment of the influence of ARVs on anthelminthics...
May 4, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28458073/community-directed-mass-drug-administration-is-undermined-by-status-seeking-in-friendship-networks-and-inadequate-trust-in-health-advice-networks
#12
Goylette F Chami, Andreas A Kontoleon, Erwin Bulte, Alan Fenwick, Narcis B Kabatereine, Edridah M Tukahebwa, David W Dunne
Over 1.9 billion individuals require preventive chemotherapy through mass drug administration (MDA). Community-directed MDA relies on volunteer community medicine distributors (CMDs) and their achievement of high coverage and compliance. Yet, it is unknown if village social networks influence effective MDA implementation by CMDs. In Mayuge District, Uganda, census-style surveys were conducted for 16,357 individuals from 3,491 households in 17 villages. Praziquantel, albendazole, and ivermectin were administered for one month in community-directed MDA to treat Schistosoma mansoni, hookworm, and lymphatic filariasis...
June 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28455237/lungworms-and-gastrointestinal-parasites-of-domestic-cats-a-european-perspective
#13
Alessio Giannelli, Gioia Capelli, Anja Joachim, Barbara Hinney, Bertrand Losson, Zvezdelina Kirkova, Magalie René-Martellet, Elias Papadopoulos, Róbert Farkas, Ettore Napoli, Emanuele Brianti, Claudia Tamponi, Antonio Varcasia, Ana Margarida Alho, Luís Madeira de Carvalho, Luís Cardoso, Carla Maia, Viorica Mircean, Andrei Daniel Mihalca, Guadalupe Miró, Manuela Schnyder, Cinzia Cantacessi, Vito Colella, Maria Alfonsa Cavalera, Maria Stefania Latrofa, Giada Annoscia, Martin Knaus, Lénaïg Halos, Frederic Beugnet, Domenico Otranto
With the exception of Aelurostrongylus abstrusus, feline lungworms have been poorly studied. Information on their distribution is patchy and mostly limited to case reports. In this study, the occurrence of feline lungworms and co-infecting gastrointestinal parasites has been investigated in 12 European countries (i.e. Austria, Belgium, Bulgaria, France, Greece, Hungary, Italy, Portugal, Romania, Spain, Switzerland and the United Kingdom). An average of 10 domestic cats, with regular outdoor access, was sampled each month for 12months, and freshly passed faeces were collected...
April 26, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28454578/evaluating-the-variation-in-the-projected-benefit-of-community-wide-mass-treatment-for-schistosomiasis-implications-for-future-economic-evaluations
#14
Hugo C Turner, James E Truscott, Alison A Bettis, Sam H Farrell, Arminder K Deol, Jane M Whitton, Fiona M Fleming, Roy M Anderson
BACKGROUND: The majority of schistosomiasis control programmes focus on targeting school-aged children. Expanding the use of community-wide mass treatment to reach more adults is under consideration. However, it should be noted that this would require a further increase in programmatic resources, international aid, and commitment for the provision of praziquantel. Consequently, it is important to understand (i) where a change of strategy would have the greatest benefit, and (ii) how generalisable the conclusions of field trials and analytical studies based on mathematical models investigating the impact of community-wide mass treatment, are to a broad range of settings...
April 28, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28452056/outbreak-of-cleidodiscus-in-juvenile-black-crappies-pomoxis-nigromaculatus-and-bath-treatment-with-praziquantel
#15
C Bader, J Jesudoss Chelladurai, K Thompson, D Starling, M T Brewer
No abstract text is available yet for this article.
April 27, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/28449690/daily-home-fortification-with-iron-as-ferrous-fumarate-versus-nafeedta-a-randomised-placebo-controlled-non-inferiority-trial-in-kenyan-children
#16
Emily M Teshome, Pauline E A Andang'o, Victor Osoti, Sofie R Terwel, Walter Otieno, Ayşe Y Demir, Andrew M Prentice, Hans Verhoef
BACKGROUND: We aimed to show the non-inferiority of home fortification with a daily dose of 3 mg iron in the form of iron as ferric sodium ethylenediaminetetraacetate (NaFeEDTA) compared with 12.5 mg iron as encapsulated ferrous fumarate in Kenyan children aged 12-36 months. In addition, we updated a recent meta-analysis to assess the efficacy of home fortification with iron-containing powders, with a view to examining diversity in trial results. METHODS: We gave chemoprevention by dihydroartemisinin-piperaquine, albendazole and praziquantel to 338 afebrile children with haemoglobin concentration ≥70 g/L...
April 28, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28440625/antischistosomal-activity-of-pyrido-1-2-a-benzimidazole-derivatives-and-correlation-with-inhibition-of-%C3%AE-hematin-formation
#17
John Okombo, Kawaljit Singh, Godfrey Mayoka, Ferdinand Ndubi, Linley Barnard, Peter M Njogu, Mathew Njoroge, Liezl Gibhard, Christel Brunschwig, Mireille Vargas, Jennifer Keiser, Timothy J Egan, Kelly Chibale
The extensive use of praziquantel against schistosomiasis raises concerns about drug resistance. New therapeutic alternatives targeting critical pathways within the parasite are therefore urgently needed. Hemozoin formation in Schistosoma presents one such target. We assessed the in vitro antischistosomal activity of pyrido[1,2-a]benzimidazoles (PBIs) and investigated correlations with their ability to inhibit β-hematin formation. We further evaluated the in vivo efficacy of representative compounds in experimental mice and conducted pharmacokinetic analysis on the most potent...
May 3, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/28437885/sesquiterpenes-evaluation-on-schistosoma-mansoni-survival-excretory-system-and-membrane-integrity
#18
Rosimeire Nunes de Oliveira, Karina Rodrigues Dos Santos, Tiago Manuel Fernandes Mendes, Vera Lúcia Garcia, Adriana Silva Santos Oliveira, Veronica de Lourdes Sierpe Jeraldo, Silmara Marques Allegretti
The main challenge in schistosomiasis control has been the emergence of drug-resistant parasites. Since the 1970's, praziquantel (PZQ) is the single drug for treatment. This fact highlights the importance to research news chemotherapeutic agents. In the last years, S. mansoni excretory system and tegument have been major targets for drug development. The purpose of this study was to evaluate the effect of sesquiterpenes, alpha-humulene and trans-caryophyllene on S. mansoni survival, excretory system and membrane integrity, after in vitro exposure...
June 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28434128/aspects-on-the-history-of-transmission-and-favor-of-distribution-of-viruses-by-iatrogenic-action-perhaps-an-example-of-a-paradigm-of-the-worldwide-spread-of-hiv
#19
REVIEW
Lutz G Gürtler, Josef Eberle
Transmission of infectious agents might be associated with iatrogenic actions of charitable help in health care. An example is the vaccination against yellow fever in USA that transmitted hepatitis B virus. Another example is injections of praziquantel for treatment and cure of schistosomiasis in Central and Northern Africa, with a focus in Egypt that has spread hepatitis C virus. There is no indication that human T-lymphotropic virus type 1 was spread by injection treatment for African trypanosomiasis, syphilis and treponematosis, but these treatments might have contributed to the early spread of human immunodeficiency virus type 1 (HIV-1) in Central Africa...
April 22, 2017: Medical Microbiology and Immunology
https://www.readbyqxmd.com/read/28412409/development-of-monoclonal-antibodies-against-sj29-and-its-possible-application-for-schistosomiasis-diagnosis
#20
Cui-Ping Ren, Quan Liu, Feng-Chun Liu, Feng-Yu Zhu, Shi-Xiang Cui, Zhen Liu, Wen-Da Gao, Miao Liu, Yong-Sheng Ji, Ji-Jia Shen
OBJECTIVE: Timely Schistosoma japonicum detection improves outcomes in schistosomiasis. Here, we established a double antibody sandwich ELISA to detect Schistosoma japonicum. METHODS: Sj29 polyclonal and monoclonal antibodies were developed and identified. A Sj29 double antibody sandwich ELISA was evaluated. RESULTS: Assay sensitivity for detecting Schistosoma japonicum circulating antigen Sj29 was 76.7% (23/30), 54.5% (18/33) and 50.0% (18/36) in patients with acute, chronic and advanced schistosomiasis...
April 12, 2017: International Journal of Infectious Diseases: IJID
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