Takatoshi Oishi, Masahiro Kashiura, Hideto Yasuda, Yuki Kishihara, Keiichiro Tominaga, Hiroyuki Tamura, Takashi Moriya
Naphazoline, a nonspecific alpha-adrenoceptor stimulant, is a potent vasoconstrictor used in nasal sprays, eye drops, and over-the-counter antiseptics. Naphazoline intoxication increases afterload by constricting the peripheral arteries, which can lead to complications including multiple organ failure. Although phentolamine, a nonselective alpha-adrenoceptor antagonist, and nicardipine, a calcium channel blocker, are used for the treatment of naphazoline intoxication, no established administration protocols currently exist...
December 24, 2023: American Journal of Emergency Medicine