Mehdi Sharifi-Rad, Nanjangud V Anil Kumar, Paolo Zucca, Elena Maria Varoni, Luciana Dini, Elisa Panzarini, Jovana Rajkovic, Patrick Valere Tsouh Fokou, Elena Azzini, Ilaria Peluso, Abhay Prakash Mishra, Manisha Nigam, Youssef El Rayess, Marc El Beyrouthy, Letizia Polito, Marcello Iriti, Natália Martins, Miquel Martorell, Anca Oana Docea, William N Setzer, Daniela Calina, William C Cho, Javad Sharifi-Rad
Oxidative stress plays an essential role in the pathogenesis of chronic diseases such as cardiovascular diseases, diabetes, neurodegenerative diseases, and cancer. Long term exposure to increased levels of pro-oxidant factors can cause structural defects at a mitochondrial DNA level, as well as functional alteration of several enzymes and cellular structures leading to aberrations in gene expression. The modern lifestyle associated with processed food, exposure to a wide range of chemicals and lack of exercise plays an important role in oxidative stress induction...
2020: Frontiers in Physiology