keyword
MENU ▼
Read by QxMD icon Read
search

Serena

keyword
https://www.readbyqxmd.com/read/29331092/deep-grey-matter-volume-loss-drives-disability-worsening-in-multiple-sclerosis
#1
Arman Eshaghi, Ferran Prados, Wallace Brownlee, Daniel R Altmann, Carmen Tur, M Jorge Cardoso, Floriana De Angelis, Steven H van de Pavert, Niamh Cawley, Nicola De Stefano, M Laura Stromillo, Marco Battaglini, Serena Ruggieri, Claudio Gasperini, Massimo Filippi, Maria A Rocca, Alex Rovira, Jaume Sastre-Garriga, Hugo Vrenken, Cyra E Leurs, Joep Killestein, Lukas Pirpamer, Christian Enzinger, Sebastien Ourselin, Claudia A M Gandini Wheeler-Kingshott, Declan Chard, Alan J Thompson, Daniel C Alexander, Frederik Barkhof, Olga Ciccarelli
OBJECTIVE: Grey matter (GM) atrophy occurs in all multiple sclerosis (MS) phenotypes. We investigated whether there is a spatiotemporal pattern of GM atrophy that is associated with faster disability accumulation in MS. METHODS: We analysed 3,604 brain high-resolution T1-weighted MRI scans from 1,417 participants: 1,214 MS patients (253 clinically-isolated syndrome[CIS], 708 relapsing-remitting[RRMS], 128 secondary-progressive[SPMS], 125 primary-progressive[PPMS]), over an average follow-up of 2...
January 13, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29330826/antibody-response-to-polyomavirus-primary-infection-high-seroprevalence-of-merkel-cell-polyomavirus-and-lymphoid-tissue-involvement
#2
Carolina Cason, Lorenzo Monasta, Nunzia Zanotta, Giuseppina Campisciano, Iva Maestri, Massimo Tommasino, Michael Pawlita, Sonia Villani, Manola Comar, Serena Delbue
Human polyomaviruses (HPyVs) asymptomatically infect the human population establishing latency in the host, and their seroprevalence can reach 90% in healthy adults. Few studies have focused on the pediatric population, and there are no reports regarding the seroprevalence of all the newly isolated HPyVs among Italian children. Therefore, we investigated the frequency of serum antibodies against 12 PyVs in 182 immunocompetent children from Northeast Italy, by means of a multiplex antibody detection system. Additionally, secondary lymphoid tissues were collected to analyze the presence of HPyV DNA sequences using a specific real-time PCRs or PCRs...
January 12, 2018: Journal of Neurovirology
https://www.readbyqxmd.com/read/29330377/phenotypic-and-functional-characterization-of-peripheral-sensory-neurons-derived-from-human-embryonic-stem-cells
#3
Abdullah Jawad Alshawaf, Serena Viventi, Wanzhi Qiu, Giovanna D'Abaco, Bryony Nayagam, Michael Erlichster, Gursharan Chana, Ian Everall, Jason Ivanusic, Efstratios Skafidas, Mirella Dottori
The dorsal root ganglia (DRG) consist of a multitude of sensory neuronal subtypes that function to relay sensory stimuli, including temperature, pressure, pain and position to the central nervous system. Our knowledge of DRG sensory neurons have been predominantly driven by animal studies and considerably less is known about the human DRG. Human embryonic stem cells (hESC) are valuable resource to help close this gap. Our previous studies reported an efficient system for deriving neural crest and DRG sensory neurons from hESC...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29327963/antemortem-diagnosis-of-coxiellosis-in-a-blue-and-gold-macaw-ara-ararauna
#4
Alison J Flanders, Justin F Rosenberg, Marjorie Bercier, Mary K Leissinger, Laura J Black, Robson F Giglio, Serena L M Craft, Whitney M Zoll, April L Childress, James F X Wellehan
A 15-year-old female blue and gold macaw ( Ara ararauna) was presented for evaluation after being found laterally recumbent, reluctant to move, and lethargic. Results of a complete blood count showed an increased number of immature heterophils with increased cytoplasmic basophilia and degranulation and the presence of a left shift. Radiographs and a computed tomography scan were performed and revealed a markedly enlarged spleen. An ultrasound-guided fine-needle aspirate of the spleen was submitted for cytologic examination and aerobic bacterial culture...
December 2017: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/29327668/impact-of-3-tesla-mri-on-interobserver-agreement-in-clinically-isolated-syndrome-a-magnims-multicentre-study
#5
Marloes Hj Hagens, Jessica Burggraaff, Iris D Kilsdonk, Serena Ruggieri, Sara Collorone, Rosa Cortese, Niamh Cawley, Emilia Sbardella, Michaela Andelova, Michael Amann, Johanna M Lieb, Patrizia Pantano, Birgit I Lissenberg-Witte, Joep Killestein, Celia Oreja-Guevara, Jens Wuerfel, Olga Ciccarelli, Claudio Gasperini, Carsten Lukas, Alex Rovira, Frederik Barkhof, Mike P Wattjes
BACKGROUND: Compared to 1.5 T, 3 T magnetic resonance imaging (MRI) increases signal-to-noise ratio leading to improved image quality. However, its clinical relevance in clinically isolated syndrome suggestive of multiple sclerosis remains uncertain. OBJECTIVES: The purpose of this study was to investigate how 3 T MRI affects the agreement between raters on lesion detection and diagnosis. METHODS: We selected 30 patients and 10 healthy controls from our ongoing prospective multicentre cohort...
January 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29327296/correction-to-dietary-intake-of-soy-and-cruciferous-vegetables-and-treatment-related-symptoms-in-chinese-american-and-non-hispanic-white-breast-cancer-survivors
#6
Sarah J O Nomura, Yi-Ting Hwang, Scarlett Lin Gomez, Teresa T Fung, Shu-Lan Yeh, Chiranjeev Dash, Laura Allen, Serena Philips, Leena Hilakivi-Clarke, Yun-Ling Zheng, Judy Huei-Yu Wang
In the original publication, the values provided for the isoflavone and glucosinolate intake variables were incorrectly labeled in Table 1. The correct values of 6.3 mg/day for isoflavone intake, and 20.4 mg/day and 50.1 mg/day for glucosinolate intake are provided in this erratum.
January 11, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29324625/comparison-of-the-ark-immunoassay-with-high-performance-liquid-chromatography-with-ultraviolet-detection-for-therapeutic-drug-monitoring-of-linezolid
#7
Simone Castoldi, Valeria Cozzi, Sara Baldelli, Serena Fucile, Emilio Clementi, Dario Cattaneo
BACKGROUND: An enzymatic immunoassay is under development by ARK Diagnostics, Inc for the quantification of plasma concentrations of linezolid (LZD). In this study, the authors aimed to assess the performance of this immunoassay using a validated high-performance liquid chromatography (HPLC) ultraviolet method as reference. METHODS: Within- and between-day in vitro inaccuracy and imprecision of the ARK LZD assay were firstly tested using spiked quality controls (QC) provided by the kit manufacturer...
February 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29324259/higher-serum-vitamin-d-levels-are-associated-with-protective-serum-cytokine-profiles-in-patients-with-ulcerative-colitis
#8
John Gubatan, Shuji Mitsuhashi, Maria Serena Longhi, Talia Zenlea, Laura Rosenberg, Simon Robson, Alan C Moss
BACKGROUND & AIMS: Vitamin D has immune modulating effects on cytokines. Serum vitamin D levels are associated with the risk of relapse in patients with ulcerative colitis (UC), through unknown mechanisms. We tested the hypothesis that this beneficial role of vitamin D on UC is mediated through anti-inflammatory serum cytokine profiles. METHODS: Serum samples from a prospective cohort of seventy UC patients in clinical remission were collected and baseline histological and endoscopic scores were recorded at enrollment...
January 8, 2018: Cytokine
https://www.readbyqxmd.com/read/29323433/electrically-driven-microengineered-bioinspired-soft-robots
#9
Su Ryon Shin, Bianca Migliori, Beatrice Miccoli, Yi-Chen Li, Pooria Mostafalu, Jungmok Seo, Serena Mandla, Alessandro Enrico, Silvia Antona, Ram Sabarish, Ting Zheng, Lorenzo Pirrami, Kaizhen Zhang, Yu Shrike Zhang, Kai-Tak Wan, Danilo Demarchi, Mehmet R Dokmeci, Ali Khademhosseini
To create life-like movements, living muscle actuator technologies have borrowed inspiration from biomimetic concepts in developing bioinspired robots. Here, the development of a bioinspired soft robotics system, with integrated self-actuating cardiac muscles on a hierarchically structured scaffold with flexible gold microelectrodes is reported. Inspired by the movement of living organisms, a batoid-fish-shaped substrate is designed and reported, which is composed of two micropatterned hydrogel layers. The first layer is a poly(ethylene glycol) hydrogel substrate, which provides a mechanically stable structure for the robot, followed by a layer of gelatin methacryloyl embedded with carbon nanotubes, which serves as a cell culture substrate, to create the actuation component for the soft body robot...
January 11, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29323295/alcohol-and-endogenous-aldehydes-damage-chromosomes-and-mutate-stem-cells
#10
Juan I Garaycoechea, Gerry P Crossan, Frédéric Langevin, Lee Mulderrig, Sandra Louzada, Fentang Yang, Guillaume Guilbaud, Naomi Park, Sophie Roerink, Serena Nik-Zainal, Michael R Stratton, Ketan J Patel
Haematopoietic stem cells renew blood. Accumulation of DNA damage in these cells promotes their decline, while misrepair of this damage initiates malignancies. Here we describe the features and mutational landscape of DNA damage caused by acetaldehyde, an endogenous and alcohol-derived metabolite. This damage results in DNA double-stranded breaks that, despite stimulating recombination repair, also cause chromosome rearrangements. We combined transplantation of single haematopoietic stem cells with whole-genome sequencing to show that this damage occurs in stem cells, leading to deletions and rearrangements that are indicative of microhomology-mediated end-joining repair...
January 11, 2018: Nature
https://www.readbyqxmd.com/read/29321072/tissue-specific-transcriptomes-of-anisakis-simplex-sensu-stricto-and-anisakis-pegreffii-reveal-potential-molecular-mechanisms-involved-in-pathogenicity
#11
Serena Cavallero, Fabrizio Lombardo, Xiaopei Su, Marco Salvemini, Cinzia Cantacessi, Stefano D'Amelio
BACKGROUND: Larval stages of the sibling species of parasitic nematodes Anisakis simplex (sensu stricto) (s.s.) (AS) and Anisakis pegreffii (AP) are responsible for a fish-borne zoonosis, known as anisakiasis, that humans aquire via the ingestion of raw or undercooked infected fish or fish-based products. These two species differ in geographical distribution, genetic background and peculiar traits involved in pathogenicity. However, thus far little is known of key molecules potentially involved in host-parasite interactions...
January 10, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29317049/autoimmunity-against-a-glycolytic-enzyme-as-a-possible-cause-for-persistent-symptoms-in-lyme-disease
#12
Paolo Maccallini, Serena Bonin, Giusto Trevisan
Some patients with a history of Borrelia burgdorferi infection develop a chronic symptomatology characterized by cognitive deficits, fatigue, and pain, despite antibiotic treatment. The pathogenic mechanism that underlines this condition, referred to as post-treatment Lyme disease syndrome (PTLDS), is currently unknown. A debate exists about whether PTLDS is due to persistent infection or to post-infectious damages in the immune system and the nervous system. We present the case of a patient with evidence of exposure to Borrelia burgdorferi sl and a long history of debilitating fatigue, cognitive abnormalities and autonomic nervous system issues...
January 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29315163/efficacy-and-safety-of-adalimumab-in-pediatric-ulcerative-colitis-a-real-life-experience-from-the-sigenp-ibd-registry
#13
Marina Aloi, Matteo Bramuzzo, Serena Arrigo, Claudio Romano, Giulia D'Arcangelo, Doriana Lacorte, Simona Gatti, Maria Teresa Illiceto, Francesca Zucconi, Dario Dilillo, Giovanna Zuin, Daniela Knafelz, Alberto Ravelli, Salvatore Cucchiara, Patrizia Alvisi
OBJECTIVES: The aim of this study was to evaluate the effectiveness and safety of adalimumab (ADA) in children with ulcerative colitis (UC) previously treated with infliximab (IFX). METHODS: Retrospective study including children with UC from a national registry who received ADA therapy. The primary endpoint was the rate of corticosteroid (CS) free remission at week 52. Secondary outcomes were: the rate of sustained clinical remission, primary non-response and loss of response at weeks 12, 30, and 52 and rate of mucosal healing (MH) and side effects at week 52...
January 6, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29314145/toward-complement-inhibition-2-0-next-generation-anti-complement-agents-for-paroxysmal-nocturnal-hemoglobinuria
#14
Antonio M Risitano, Serena Marotta
Therapeutic complement inhibition by eculizumab has revolutionized the treatment of paroxysmal nocturnal hemoglobinuria (PNH) with a major impact on its natural history. Nevertheless, emerging unmet clinical needs may benefit from the development of novel complement inhibitors. Novel strategies of complement inhibition exploit different agents targeting C5, as well as compound intercepting the complement cascade at the level of its key component C3, or even upstream at the level of components involved in complement alternative pathway initiation...
January 4, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29313801/correction-optical-control-of-pain-in-vivo-with-a-photoactive-mglu5-receptor-negative-allosteric-modulator
#15
Joan Font, Marc López-Cano, Serena Notartomaso, Pamela Scarselli, Paola Di Prieto, Roger Bresolí-Obach, Giuseppe Battaglia, Fanny Malhaire, Xavier Rovira, Juanlo Catena, Jesús Giraldo, Jean-Philippe Pin, Víctor Fernández-Dueñas, Cyril Goudet, Santi Nonell, Ferdinando Nicoletti, Amadeu Llebaria, Francisco Ciruela
No abstract text is available yet for this article.
January 8, 2018: ELife
https://www.readbyqxmd.com/read/29313679/a-pair-natural-orbitals-restricted-open-shell-configuration-interaction-pno-rocis-approach-for-calculating-x-ray-absorption-spectra-of-large-chemical-systems
#16
Dimitrios Maganas, Serena DeBeer, Frank Neese
In this work, the efficiency of first principles calculations of X-ray absorption spectra of large chemical systems is drastically improved. The approach is based on the previously developed restricted open shell configuration interaction singles (ROCIS) method and its parameterized version, based on a density functional theory (DFT) ground state determinant ROCIS/DFT. The combination of the ROCIS or DFT/ROCIS methods with the well-known machinery of the pair natural orbitals (PNOs) leads to the new PNO-ROCIS and PNO-ROCIS/DFT variants...
January 9, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29311610/interneuron-specific-signaling-evokes-distinctive-somatostatin-mediated-responses-in-adult-cortical-astrocytes
#17
Letizia Mariotti, Gabriele Losi, Annamaria Lia, Marcello Melone, Angela Chiavegato, Marta Gómez-Gonzalo, Michele Sessolo, Serena Bovetti, Angelo Forli, Micaela Zonta, Linda Maria Requie, Iacopo Marcon, Arianna Pugliese, Cécile Viollet, Bernhard Bettler, Tommaso Fellin, Fiorenzo Conti, Giorgio Carmignoto
The signaling diversity of GABAergic interneurons to post-synaptic neurons is crucial to generate the functional heterogeneity that characterizes brain circuits. Whether this diversity applies to other brain cells, such as the glial cells astrocytes, remains unexplored. Using optogenetics and two-photon functional imaging in the adult mouse neocortex, we here reveal that parvalbumin- and somatostatin-expressing interneurons, two key interneuron classes in the brain, differentially signal to astrocytes inducing weak and robust GABAB receptor-mediated Ca2+ elevations, respectively...
January 8, 2018: Nature Communications
https://www.readbyqxmd.com/read/29311574/lateralized-behavior-and-cardiac-activity-of-dogs-in-response-to-human-emotional-vocalizations
#18
Marcello Siniscalchi, Serenella d'Ingeo, Serena Fornelli, Angelo Quaranta
Over the recent years, the study of emotional functioning has become one of the central issues in dog cognition. Previous studies showed that dogs can recognize different emotions by looking at human faces and can correctly match the human emotional state with a vocalization having a negative emotional valence. However, to this day, little is known about how dogs perceive and process human non-verbal vocalizations having different emotional valence. The current research provides new insights into emotional functioning of the canine brain by studying dogs' lateralized auditory functions (to provide a first insight into the valence dimension) matched with both behavior and physiological measures of arousal (to study the arousal dimension) in response to playbacks related to the Ekman's six basic human emotions...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29311029/recurrent-biliary-acute-pancreatitis-is-frequent-in-a-real-world-setting
#19
Serena Stigliano, Flaminia Belisario, Matteo Piciucchi, Marianna Signoretti, Gianfranco Delle Fave, Gabriele Capurso
BACKGROUND: Data about recurrent acute pancreatitis (RAP) are limited. AIMS: To evaluate the rate of RAP and associated factors. METHODS: Single-centre prospective study of consecutive patients at first episode of acute pancreatitis (AP) being followed-up. RESULTS: Of 266 consecutive AP patients, (47% biliary, 15.4% alcoholic, 14.3% idiopathic) 66 (24.8%) had RAP in a mean follow-up of 42 months; 17.9% of recurrences occurred within 30 days from discharge...
December 19, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29306990/peer-support-and-the-hiv-continuum-of-care-results-from-a-multi-site-randomized-clinical-trial-in-three-urban-clinics-in-the-united-states
#20
Howard J Cabral, Kendra Davis-Plourde, Mariana Sarango, Jane Fox, Joseph Palmisano, Serena Rajabiun
Racial/ethnic minorities living with HIV and behavioral health co-morbidities are more likely to be disengaged from HIV primary care. Peer programs have been effective in HIV outreach and prevention but effectiveness of such programs for retention in care and viral suppression is understudied. Subjects (n = 348) were randomized in equal allocation to a peer navigation and education intervention versus standard clinical care at three urban clinics in the United States. The intervention group received seven structured interventions plus weekly contact to address medical and social needs...
January 6, 2018: AIDS and Behavior
keyword
keyword
96827
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"