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PET MR

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https://www.readbyqxmd.com/read/29166756/use-of-imaging-techniques-in-large-vessel-vasculitis-and-related-conditions
#1
Annibale Versari, Nicolò Pipitone, Massimiliano Casali, Francois Jamar, Giulia Pazzola
Giant Cell Arteritis (GCA) and Takayasu's arteritis (TA) are large vessel vasculitis (LVV) primarily affecting the aorta and its major branches, mainly differentiated by the onset age (>50 years GCA and <40 years TA). In addition, temporal artery involvement and polymyalgia rheumatic are typical features of GCA, but not TA. Imaging techniques are required to secure the diagnosis of large-vessel vasculitides, and to monitor the disease course. Both morphological and metabolic imaging are involved. Morphological imaging is represented mainly by Computerized Tomography (CT), CT angiography, Magnetic Resonance (MR), MR angiography, Color-Doppler Sonography (CDS) and high-resolution CDS...
November 22, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29163024/pet-mr-imaging-new-frontier-in-alzheimer-s-disease-and-other-dementias
#2
REVIEW
Xin Y Zhang, Zhen L Yang, Guang M Lu, Gui F Yang, Long J Zhang
Alzheimer's disease (AD) is the most common form of dementia; a progressive neurodegenerative disease that currently lacks an effective treatment option. Early and accurate diagnosis, in addition to quick elimination of differential diagnosis, allows us to provide timely treatments that delay the progression of AD. Imaging plays an important role for the early diagnosis of AD. The newly emerging PET/MR imaging strategies integrate the advantages of PET and MR to diagnose and monitor AD. This review introduces the development of PET/MR imaging systems, technical considerations of PET/MR imaging, special considerations of PET/MR in AD, and the system's potential clinical applications and future perspectives in AD...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29159046/imaging-of-glia-activation-in-people-with-primary-lateral-sclerosis
#3
Sabrina Paganoni, Mohamad J Alshikho, Nicole R Zürcher, Paul Cernasov, Suma Babu, Marco L Loggia, James Chan, Daniel B Chonde, David Izquierdo Garcia, Ciprian Catana, Caterina Mainero, Bruce R Rosen, Merit E Cudkowicz, Jacob M Hooker, Nazem Atassi
Background: Glia activation is thought to contribute to neuronal damage in several neurodegenerative diseases based on preclinical and human post-mortem studies, but its role in primary lateral sclerosis (PLS) is unknown. Objectives: To localize and measure glia activation in people with PLS compared to healthy controls (HC). Methods: Ten participants with PLS and ten age-matched HCs underwent simultaneous magnetic resonance (MR) and proton emission tomography (PET)...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29157849/imaging-of-chronic-concussion
#4
REVIEW
Eliana Bonfante, Roy Riascos, Octavio Arevalo
Conventional imaging findings in patients with cerebral concussion and chronic traumatic encephalopathy are absent or subtle in the majority of cases. The most common abnormalities include cerebral volume loss, enlargement of the cavum of the septum pellucidum, cerebral microhemorrhages, and white matter signal abnormalities, all of which have poor sensitivity and specificity. Advanced imaging modalities, such as diffusion tensor imaging (DTI), blood oxygen level dependent functional MR Imaging (BOLD fMRI), MR spectroscopy, perfusion imaging, positron emission tomography (PET), single photon emission computed tomography (SPECT), and magnetoencephalography detect physiologic abnormalities in symptomatic patients and, although currently in the investigation phase, may become useful in the clinical arena...
February 2018: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/29157390/practical-considerations-for-clinical-pet-mr-imaging
#5
REVIEW
Samuel Galgano, Zachary Viets, Kathryn Fowler, Lael Gore, John V Thomas, Michelle McNamara, Jonathan McConathy
Clinical PET/MR imaging is currently performed at a number of centers around the world as part of routine standard of care. This article focuses on issues and considerations for a clinical PET/MR imaging program, focusing on routine standard-of-care studies. Although local factors influence how clinical PET/MR imaging is implemented, the approaches and considerations described here intend to apply to most clinical programs. PET/MR imaging provides many more options than PET/computed tomography with diagnostic advantages for certain clinical applications but with added complexity...
January 2018: PET Clinics
https://www.readbyqxmd.com/read/29157389/improved-detection-of-small-pulmonary-nodules-through-simultaneous-mr-pet-imaging
#6
REVIEW
Fernando E Boada, Thomas Koesters, Kai Tobias Block, Hersh Chandarana
Magnetic resonance (MR)/PET scanners provide an imaging platform that enables simultaneous acquisition of MR and PET data in perfect spatial and temporal registration. This feature allows improving image quality for the MR and PET images obtained during the course of an examination. In this work the authors demonstrate the use of prospective MR-based motion tracking information for removing motion blur in MR/PET images of small pulmonary nodules. The theoretical basis for the algorithms is presented alongside clinical examples of its use...
January 2018: PET Clinics
https://www.readbyqxmd.com/read/29155635/case-248-cystic-duodenal-dystrophy-with-groove-pancreatitis
#7
Aruna R Patil, Shrivalli Nandikoor, Govindarajan Mallarajapatna, Swarna Shivakumar
History A 59-year-old man presented to the gastroenterology outpatient department with acute abdominal pain centered in the epigastrium. He had experienced similar episodes of abdominal pain in the past that had been treated with surgery. He reported multiple failed attempts at upper gastrointestinal endoscopy. Laboratory tests were performed at the time of admission and revealed a serum glutamic-oxaloacetic transaminase level of 9 U/L [0.15 μkat/L] (normal range, 5-40 U/L [0.08-0.67 μkat/L]), a serum glutamic-pyruvic transaminase level of 34 U/L [0...
December 2017: Radiology
https://www.readbyqxmd.com/read/29153465/impact-of-hybrid-pet-mr-technology-on-multiparametric-imaging-and-treatment-response-assessment-of-cervix-cancer
#8
Michaela Daniel, Piotr Andrzejewski, Alina Sturdza, Katarina Majercakova, Pascal Baltzer, Katja Pinker, Wolfgang Wadsak, Markus Mitterhauser, Richard Pötter, Petra Georg, Thomas Helbich, Dietmar Georg
BACKGROUND AND PURPOSE: Multimodal tissue characterization by combined MRI and PET has high clinical potential in the context of sub-target definition for dose painting and response assessment but its clinical exploration is yet limited. The aim of this study was to prove the potential and feasibility of hybrid PET/MRI to non-invasively measure tumor hypoxia, perfusion and microstructure at one stop in tumors of the uterine cervix during chemoradiotherapy. MATERIAL AND METHODS: Ten cervix cancer patients were subjected to simultaneous multiparametric PET/MRI with [(18)F]fluoromisonidazole ([(18)F]FMISO)...
November 15, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29136287/quantification-of-mri-visibility-and-artefacts-at-3t-of-liquid-fiducial-marker-in-a-pancreas-tissue-mimicking-phantom
#9
Sergej Schneider, Rasmus Irming Jølck, Esther Gera Cornelia Troost, Aswin Louis Hoffmann
PURPOSE: X-ray based position verification of the target volume in image-guided radiation therapy (IGRT) of patients with pancreatic ductal adenocarcinoma (PDAC) is currently performed on solid fiducial markers that are implanted under endoscopic ultrasonography. A new biodegradable liquid fiducial marker has recently been introduced. To assess its potential use for magnetic resonance imaging (MRI) guided photon or proton radiotherapy of PDAC, the MRI visibility and artefacts of this marker were quantified and compared against solid gold markers...
November 14, 2017: Medical Physics
https://www.readbyqxmd.com/read/29134288/task-relevant-brain-networks-identified-with-simultaneous-pet-mr-imaging-of-metabolism-and-connectivity
#10
Andreas Hahn, Gregor Gryglewski, Lukas Nics, Lucas Rischka, Sebastian Ganger, Helen Sigurdardottir, Chrysoula Vraka, Leo Silberbauer, Thomas Vanicek, Alexander Kautzky, Wolfgang Wadsak, Markus Mitterhauser, Markus Hartenbach, Marcus Hacker, Siegfried Kasper, Rupert Lanzenberger
Except for task-specific functional MRI, the vast majority of imaging studies assessed human brain function at resting conditions. However, tracking task-specific neuronal activity yields important insight how the brain responds to stimulation. We specifically investigated changes in glucose metabolism, functional connectivity and white matter microstructure during task performance using several recent methodological advancements. Opening the eyes and right finger tapping had elicited an increased glucose metabolism in primary visual and motor cortices, respectively...
November 13, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/29133818/searching-for-prostate-cancer-by-fully-automated-magnetic-resonance-imaging-classification-deep-learning-versus-non-deep-learning
#11
Xinggang Wang, Wei Yang, Jeffrey Weinreb, Juan Han, Qiubai Li, Xiangchuang Kong, Yongluan Yan, Zan Ke, Bo Luo, Tao Liu, Liang Wang
Prostate cancer (PCa) is a major cause of death since ancient time documented in Egyptian Ptolemaic mummy imaging. PCa detection is critical to personalized medicine and varies considerably under an MRI scan. 172 patients with 2,602 morphologic images (axial 2D T2-weighted imaging) of the prostate were obtained. A deep learning with deep convolutional neural network (DCNN) and a non-deep learning with SIFT image feature and bag-of-word (BoW), a representative method for image recognition and analysis, were used to distinguish pathologically confirmed PCa patients from prostate benign conditions (BCs) patients with prostatitis or prostate benign hyperplasia (BPH)...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29133278/imaging-for-the-detection-of-locoregional-recurrences-in-biochemical-progression-after-radical-prostatectomy-a-systematic-review
#12
REVIEW
Kristina Sandgren, Philippe Westerlinck, Joakim H Jonsson, Lennart Blomqvist, Camilla Thellenberg Karlsson, Tufve Nyholm, Piet Dirix
CONTEXT: Local and regional recurrence after radical prostatectomy (RP) can be treated using salvage radiotherapy (SRT). If the recurrence can be delineated on diagnostic imaging, this could allow for increasingly individualized SRT. OBJECTIVE: This systematic review aimed at evaluating the evidence regarding the usefulness of positron emission tomography (PET) and magnetic resonance imaging (MRI) in identifying local and regional recurrences, with the aim to further individualize the SRT treatment...
November 10, 2017: European Urology Focus
https://www.readbyqxmd.com/read/29128003/pet-mr-imaging-in-head-and-neck-cancer-current-applications-and-future-directions
#13
REVIEW
Samuel J Galgano, Ryan V Marshall, Erik H Middlebrooks, Jonathan E McConathy, Pradeep Bhambhvani
Clinical PET/MR imaging is being implemented at institutions worldwide as part of the standard-of-care imaging for select oncology patients. This article focuses on oncologic applications of PET/MR imaging in cancers of the head and neck. Although current published literature is relatively sparse, the potential benefits of a hybrid modality of PET/MR imaging are discussed along with several possible areas of research. With the increasing number of PET/MR imaging scanners in clinical use and ongoing research, the role of PET/MR imaging in the management of head and neck cancer is likely to become more evident in the near future...
February 2018: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/29127246/non-oncologic-applications-of-pet-ct-and-pet-mr-in-musculoskeletal-orthopedic-and-rheumatologic-imaging-general-considerations-techniques-and-radiopharmaceuticals
#14
Ali Gholamrezanezhad, Kyle Basques, Ali Batouli, Mojtaba Olyaie, George Matcuk, Abass Alavi, Hossein Jadvar
Positron Emission Tomography (PET) is often underutilized in the field of musculoskeletal imaging, with key reasons including the excellent performance of conventional musculoskeletal MRI, the limited spatial resolution of PET, and the lack of reimbursement for PET for non-oncologic musculoskeletal indications. However, with improvements in PET/CT and PET/MR imaging over the last decade as well as an increased understanding of the pathophysiology of musculoskeletal diseases, there is an emerging potential for PET as a primary or complementary modality in the management of rheumatologic and orthopedic patients...
November 10, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/29123008/reproducibility-of-mr-based-attenuation-maps-in-pet-mri-and-the-impact-on-pet-quantification-in-lung-cancer
#15
Anders Olin, Claes N Ladefoged, Natasha H Langer, Sune H Keller, Johan O Löfgren, Adam E Hansen, Andreas Kjær, Seppo W Langer, Barbara M Fischer, Flemming L Andersen
AIM: Quantitative positron emission tomography/magnetic resonance imaging (PET/MRI) is dependent upon reliable and reproducible MR-based attenuation correction (MR-AC). In this study we evaluated the quality of current vendor-provided thoracic MR-AC maps, and further investigated the reproducibility of these in terms of their impact on fluorodeoxyglucose (FDG)-PET quantification in patients with non-small cell lung cancer (NSCLC). MATERIAL AND METHODS: Eleven patients with inoperable NSCLC underwent two to five thoracic PET/MRI scan-rescan examinations within 22 days...
November 9, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29119237/impact-of-improved-attenuation-correction-featuring-a-bone-atlas-and-truncation-correction-on-pet-quantification-in-whole-body-pet-mr
#16
Mark Oehmigen, Maike E Lindemann, Marcel Gratz, Julian Kirchner, Verena Ruhlmann, Lale Umutlu, Jan Ole Blumhagen, Matthias Fenchel, Harald H Quick
PURPOSE: Recent studies have shown an excellent correlation between PET/MR and PET/CT hybrid imaging in detecting lesions. However, a systematic underestimation of PET quantification in PET/MR has been observed. This is attributable to two methodological challenges of MR-based attenuation correction (AC): (1) lack of bone information, and (2) truncation of the MR-based AC maps (μmaps) along the patient arms. The aim of this study was to evaluate the impact of improved AC featuring a bone atlas and truncation correction on PET quantification in whole-body PET/MR...
November 9, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29116483/pittsburgh-compound-b-pib-pet-imaging-of-meningioma-and-other-intracranial-tumors
#17
Derek R Johnson, Christopher H Hunt, Mark A Nathan, Joseph E Parisi, Bradley F Boeve, Melissa E Murray, David S Knopman, Clifford R Jack, Ronald C Petersen, Val J Lowe, Geoffrey B Johnson
Meningiomas are the most common intracranial tumors. Diagnosis by MRI is generally straightforward, but lack of imaging specificity can present a diagnostic dilemma, particularly in patients with cancer. We report our experience with meningioma identification on Pittsburgh compound B (PiB) PET/CT. Patients who underwent PiB PET/CT from 2006 to 2015 were reviewed to identify those with intracranial tumors. Tumor types were classified by MR appearance, or by pathology when available. Maximum standardized uptake value (SUVmax) measurements of tumor PiB activity were compared across tumor types...
November 8, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29116052/quantitative-performance-evaluation-of-sup-124-sup-i-pet-mri-lesion-dosimetry-in-differentiated-thyroid-cancer
#18
Roel Wierts, Walter Jentzen, Harald H Quick, Hendrik J Wisselink, Ivo N A Pooters, Joachim E Wildberger, Ken Herrmann, Gerrit J Kemerink, Walter H Backes, Felix M Mottaghy
The aim was to investigate the quantitative performance of 124I PET/MRI for pre-therapy lesion dosimetry in differentiated thyroid cancer. Phantom measurements were performed on a PET/MRI system (Biograph mMR, Siemens Healthcare) using 124I and 18F. The PET calibration factor and the influence of radiofrequency coil attenuation were determined using a cylindrical phantom homogeneously filled with radioactivity. The calibration factor was 1.00 ± 0.02 for 18F and 0.88 ± 0.02 for 124I. Near the radiofrequency surface coil an underestimation of less than 5% in radioactivity concentration was observed...
November 8, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29114177/associations-between-18-f-fdg-pet-dwi-and-dce-parameters-in-patients-with-head-and-neck-squamous-cell-carcinoma-depend-on-tumor-grading
#19
Leonard Leifels, Sandra Purz, Patrick Stumpp, Stefan Schob, Hans Jonas Meyer, Thomas Kahn, Osama Sabri, Alexey Surov
Our purpose was to analyze associations between positron emission tomography (PET), diffusion weighted imaging (DWI), and dynamic contrast-enhanced (DCE) imaging in patients with head and neck squamous cell carcinoma (HNSCC). The study involved 34 patients (9 women, 25 men, mean age: 56.7 ± 10.2 years). In all patients a simultaneous (18)F-FDG-PET/MR was performed. DWI was obtained by using of an axial EPI sequence. Minimal ADC values (ADCmin), mean ADC values (ADCmean), and maximal ADC values (ADCmax) were estimated...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29110648/prospective-study-of-11-c-methionine-pet-for-distinguishing-between-recurrent-brain-metastases-and-radiation-necrosis-%C3%A2-limitations-of-diagnostic-accuracy-and-long-term-results-of-salvage-treatment
#20
Shoji Yomo, Kazuhiro Oguchi
BACKGROUND: On conventional diagnostic imaging, the features of radiation necrosis (RN) are similar to those of local recurrence (LR) of brain metastases (BM). (11)C-methionine positron emission tomography (MET-PET) is reportedly useful for making a differential diagnosis between LR and RN. In this prospective study, we aimed to investigate the diagnostic performance of MET-PET and the long-term results of subsequent patient management. METHODS: The eligible subjects had enlarging contrast-enhanced lesions (>1 cm) on MR imaging after any form of radiotherapy for BM, suggesting LR or RN...
November 6, 2017: BMC Cancer
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