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https://www.readbyqxmd.com/read/28817956/the-role-of-intrinsic-brain-functional-connectivity-in-vulnerability-and-resilience-to-bipolar-disorder
#1
Gaelle E Doucet, Danielle S Bassett, Nailin Yao, David C Glahn, Sophia Frangou
OBJECTIVE: Bipolar disorder is a heritable disorder characterized by mood dysregulation associated with brain functional dysconnectivity. Previous research has focused on the detection of risk- and disease-associated dysconnectivity in individuals with bipolar disorder and their first-degree relatives. The present study seeks to identify adaptive brain connectivity features associated with resilience, defined here as avoidance of illness or delayed illness onset in unaffected siblings of patients with bipolar disorder...
August 18, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28817196/technical-note-quantitative-analysis-of-ivim-diffusion-mri-using-total-variation-and-huber-penalty-function
#2
Esha Baidya Kayal, Devasenathipathy Kandasamy, Kedar Khare, Jayendra Tiru Alampally, Sameer Bakhshi, Raju Sharma, Amit Mehndiratta
PURPOSE: Quantitative analysis in Intra-voxel Incoherent Motion (IVIM) imaging commonly uses voxel-wise estimation of the bi-exponential model, which might not be reliable for clinical interpretation. Improving model fitting performance and qualitative and quantitative parametric estimation, two novel methodologies are proposed here. METHODS: Five IVIM analyses methodologies: i) Bi-Exponential (BE) model, ii) Segmented BE method with 2-parameter fitting (BEseg-2), iii) Segmented BE method with 1-parameter fitting (BEseg-1), iv) BE with adaptive Total Variation Penalty function (BE+TV) and v) BE with adaptive Huber Penalty function (BE+HPF) were evaluated...
August 17, 2017: Medical Physics
https://www.readbyqxmd.com/read/28816159/consensus-guidelines-for-implementing-pencil-beam-scanning-proton-therapy-for-thoracic-malignancies-on-behalf-of-the-ptcog-thoracic-and-lymphoma-subcommittee
#3
REVIEW
Joe Y Chang, Xiaodong Zhang, Antje Knopf, Heng Li, Shinichiro Mori, Lei Dong, Hsiao-Ming Lu, Wei Liu, Shahed N Badiyan, Stephen Both, Arturs Meijers, Liyong Lin, Stella Flampouri, Zuofeng Li, Kikuo Umegaki, Charles B Simone, Xiaorong R Zhu
Pencil-beam scanning (PBS) proton therapy (PT), particularly intensity modulated PT, represents the latest advanced PT technology for treating cancers, including thoracic malignancies. On the basis of virtual clinical studies, PBS-PT appears to have great potential in its ability to tightly tailor the dose to the target while sparing critical structures, thereby reducing treatment-related toxicities, particularly for tumors in areas with complicated anatomy. However, implementing PBS-PT for moving targets has several additional technical challenges compared with intensity modulated photon radiation therapy or passive scattering PT...
September 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28814637/asymmetric-vestibular-stimulation-reveals-persistent-disruption-of-motion-perception-in-unilateral-vestibular-lesions
#4
Roberto Panichi, Mario Faralli, Rosa Bruni, Artemis Kiriakarely, Chiara Occhigrossi, Aldo Ferraresi, Adolfo M Bronstein, Vito Enrico Pettorossi
Self-motion perception was studied in patients with unilateral vestibular lesions (UVL) due to acute vestibular neuritis at 1 week, 4, 8 and 12 months after the acute episode. We assessed vestibularly-mediated self-motion perception by measuring the error in reproducing the position of a remembered visual target at the end of 4 cycles of asymmetric whole-body rotation. The oscillatory stimulus consists of a slow (0.09Hz) and a fast (0.38Hz) half cycle. A large error was present in UVL patients when the slow half cycle was delivered towards the lesion side, but minimal towards the healthy side...
August 16, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28814456/downregulation-of-early-visual-cortex-excitability-mediates-oscillopsia-suppression
#5
Hena Ahmad, R Edward Roberts, Mitesh Patel, Rhannon Lobo, Barry Seemungal, Qadeer Arshad, Adolfo Bronstein
OBJECTIVE: To identify in an observational study the neurophysiologic mechanisms that mediate adaptation to oscillopsia in patients with bilateral vestibular failure (BVF). METHODS: We directly probe the hypothesis that adaptive changes that mediate oscillopsia suppression implicate the early visual-cortex (V1/V2). Accordingly, we investigated V1/V2 excitability using transcranial magnetic stimulation (TMS) in 12 avestibular patients and 12 healthy controls. Specifically, we assessed TMS-induced phosphene thresholds at baseline and cortical excitability changes while performing a visual motion adaptation paradigm during the following conditions: baseline measures (i...
August 16, 2017: Neurology
https://www.readbyqxmd.com/read/28814008/self-aligning-exoskeleton-hip-joint-kinematic-design-with-five-revolute-three-prismatic-and-one-ball-joint
#6
Jonas Beil, Charlotte Marquardt, Tamim Asfour
Kinematic compatibility is of paramount importance in wearable robotic and exoskeleton design. Misalignments between exoskeletons and anatomical joints of the human body result in interaction forces which make wearing the exoskeleton uncomfortable and even dangerous for the human. In this paper we present a kinematically compatible design of an exoskeleton hip to reduce kinematic incompatibilities, so called macro- and micro-misalignments, between the human's and exoskeleton's joint axes, which are caused by inter-subject variability and articulation...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813978/evaluation-of-3d-printed-anatomically-scalable-transfemoral-prosthetic-knee
#7
Tyagi Ramakrishnan, Millicent Schlafly, Kyle B Reed
This case study compares a transfemoral amputee's gait while using the existing Ossur Total Knee 2000 and our novel 3D printed anatomically scalable transfemoral prosthetic knee. The anatomically scalable transfemoral prosthetic knee is 3D printed out of a carbon-fiber and nylon composite that has a gear-mesh coupling with a hard-stop weight-actuated locking mechanism aided by a cross-linked four-bar spring mechanism. This design can be scaled using anatomical dimensions of a human femur and tibia to have a unique fit for each user...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813952/comparative-performance-analysis-of-m-imu-emg-and-voice-user-interfaces-for-assistive-robots
#8
Clemente Laureiti, Francesca Cordella, Francesco Scotto di Luzio, Stefano Saccucci, Angelo Davalli, Rinaldo Sacchetti, Loredana Zollo
People with a high level of disability experience great difficulties to perform activities of daily living and resort to their residual motor functions in order to operate assistive devices. The commercially available interfaces used to control assistive manipulators are typically based on joysticks and can be used only by subjects with upper-limb residual mobilities. Many other solutions can be found in the literature, based on the use of multiple sensory systems for detecting the human motion intention and state...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813871/clinical-effectiveness-of-combined-virtual-reality-and-robot-assisted-fine-hand-motion-rehabilitation-in-subacute-stroke-patients
#9
Xianwei Huang, Fazel Naghdy, Golshah Naghdy, Haiping Du
Robot-assisted therapy is regarded as an effective and reliable method for the delivery of highly repetitive rehabilitation training in restoring motor skills after a stroke. This study focuses on the rehabilitation of fine hand motion skills due to their vital role in performing delicate activities of daily living (ADL) tasks. The proposed rehabilitation system combines an adaptive assist-as-needed (AAN) control algorithm and a Virtual Reality (VR) based rehabilitation gaming system (RGS). The developed system is described and its effectiveness is validated through clinical trials on a group of eight subacute stroke patients for a period of six weeks...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813863/comparison-of-kinematic-and-emg-parameters-between-unassisted-fixed-and-adaptive-stiffness-robotic-assisted-ankle-movements-in-post-stroke-subjects
#10
Juan C Perez-Ibarra, Adriano A G Siqueira
In this paper, we present an assist-as-needed scheme that effectively adapted the assistance provided by an ankle rehabilitation robot according to patient's participation and performance during therapeutic movements. We performed an error-based estimation of the ankle impedance as a valid measure of the patient participation. Then, we computed the amount of robotic assistance by three steps: normalization of the combined patient-robot stiffness, optimization of patientrobot interaction, and finally, adaptation of the level of the robotic assistance according to patient's performance while playing a serious game...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813862/on-the-stiffness-analysis-of-a-cable-driven-leg-exoskeleton
#11
N S S Sanjeevi, Vineet Vashista
Robotic systems are being used for gait rehabilitation of patients with neurological disorder. These devices are externally powered to apply external forces on human limbs to assist the leg motion. Patients while walking with these devices adapt their walking pattern in response to the applied forces. The efficacy of a rehabilitation paradigm thus depends on the human-robot interaction. A cable driven leg exoskeleton (CDLE) use actuated cables to apply external joint torques on human leg. Cables are lightweight and flexible but can only be pulled, thus a CDLE requires redundant cables...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813855/an-optimized-design-of-a-parallel-robot-for-gait-training
#12
Marco Maddalena, Mozafar Saadat, Alireza Rastegarpanah, Rui C V Loureiro
The guidelines for enhancing robot-assisted training for post-stroke survivors head towards increasing exercise realism and variability; in particular lower limb rehabilitation needs the patient to feel challenged to adapt his locomotion and dynamic balance capabilities to different virtual ground scenarios. This paper proposes a design for a robot whose end-effector acts as a footplate to be in permanent contact with the user's foot during practice: the structure is such that it enables the user's foot to rotate around three axis, differently from what is currently available in the research for gait training; the parallel kinematic structure and the dimensional synthesis allow a suitable range of motion and aim at limiting device mass, footprint and reaction forces on the actuators when rendering virtual ground...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813853/towards-human-knee-orthosis-interaction-based-on-adaptive-impedance-control-through-stiffness-adjustment
#13
Joana Figueiredo, Paulo Felix, Cristina P Santos, Juan C Moreno
Rehabilitation interventions involving powered, wearable lower limb orthoses that can provide high-challenging locomotor tasks for repetitive training sessions, mainly when assist-as-needed strategies, such as adaptive impedance control, are designed. In this study, the adaptive behavior was ensured by software control of the robotic stiffness involved in the human-knee orthosis interaction in function of the gait cycle and speed. To estimate the stiffness, we analyzed the interaction torque-angle characteristics with experimental data...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813841/design-and-preliminary-evaluation-of-a-multi-robotic-system-with-pelvic-and-hip-assistance-for-pediatric-gait-rehabilitation
#14
Evelyn J Park, Jiyeon Kang, Hao Su, Paul Stegall, Daniel L Miranda, Wen-Hao Hsu, Mustafa Karabas, Nathan Phipps, Sunil K Agrawal, Eugene C Goldfield, Conor J Walsh
This paper presents a modular, computationally-distributed "multi-robot" cyberphysical system designed to assist children with developmental delays in learning to walk. The system consists of two modules, each assisting a different aspect of gait: a tethered cable pelvic module with up to 6 degrees of freedom (DOF), which can modulate the motion of the pelvis in three dimensions, and a two DOF wearable hip module assisting lower limb motion, specifically hip flexion. Both modules are designed to be lightweight and minimally restrictive to the user, and the modules can operate independently or in cooperation with each other, allowing flexible system configuration to provide highly customized and adaptable assistance...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813839/timing-of-intermittent-torque-control-with-wire-driven-gait-training-robot-lifting-toe-trajectory-for-trip-avoidance
#15
Tamon Miyake, Yo Kobayashi, Masakatsu G Fujie, Shigeki Sugano
Gait training robots are useful for changing gait patterns and decreasing risk of trip. Previous research has reported that decreasing duration of the assistance or guidance of the robot is beneficial for efficient gait training. Although robotic intermittent control method for assisting joint motion has been established, the effect of the robot intervention timing on change of toe clearance is unclear. In this paper, we tested different timings of applying torque to the knee, employing the intermittent control of a gait training robot to increase toe clearance throughout the swing phase...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813835/motor-adaptation-to-lateral-pelvis-assistance-force-during-treadmill-walking-in-individuals-post-stroke
#16
Ming Wu, Chao-Jung Hsu, Janis Kim
The goal of this study was to determine how individuals post-stroke response to the lateral assistance force applied to the pelvis during treadmill walking. Ten individuals post chronic (> 6 months) stroke were recruited to participate in this study. A controlled assistance force (∼10% of body weight) was applied to the pelvis in the lateral direction toward the paretic side during stance of the paretic leg. Kinematics of the pelvis and legs were recorded. Applying pelvis assistance force facilitated weight shifting toward the paretic side, resulting in a more symmetrical gait pattern but also inducing an enlarged range of motion of the pelvis during early adaptation period...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28808639/comparison-of-cyclic-fatigue-life-of-nickel-titanium-files-an-examination-using-high-speed-camera
#17
Taha Özyürek, Neslihan Büşra Keskin, Fatma Furuncuoğlu, Uğur İnan
OBJECTIVES: To determine the actual revolutions per minute (rpm) values and compare the cyclic fatigue life of Reciproc (RPC, VDW GmbH), WaveOne (WO, Dentsply Maillefer), and TF Adaptive (TFA, Axis/SybronEndo) nickel-titanium (NiTi) file systems using high-speed camera. MATERIALS AND METHODS: Twenty RPC R25 (25/0.08), 20 WO Primary (25/0.08), and 20 TFA ML 1 (25/0.08) files were employed in the present study. The cyclic fatigue tests were performed using a dynamic cyclic fatigue testing device, which has an artificial stainless steel canal with a 60° angle of curvature and a 5-mm radius of curvature...
August 2017: Restorative Dentistry & Endodontics
https://www.readbyqxmd.com/read/28807513/second-generation-prototype-of-a-variable-stiffness-transverse-plane-adapter-for-a-lower-limb-prosthesis
#18
Corey Pew, Glenn K Klute
The prescription and fitting of a traditional lower limb prosthesis often focuses on straight walking, neglecting maneuvers such as turning and pivoting that require flexibility in the transverse plane. Current devices that allow transverse plane movement only offer a fixed stiffness and are incapable of adapting to varying daily activities. Pilot testing of a first-generation variable stiffness torsion adapter (VSTA I) showed a benefit for individuals with lower limb amputation by reducing peak transverse plane moments at the residual limb which could lead to increased comfort, but testing was limited due to excessive device height and mass...
August 11, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28807106/developmental-adaptations-of-trypanosome-motility-to-the-tsetse-fly-host-environments-unravel-a-multifaceted-in-vivo-microswimmer-system
#19
Sarah Schuster, Timothy Krüger, Ines Subota, Sina Thusek, Brice Rotureau, Andreas Beilhack, Markus Engstler
The highly motile and versatile protozoan pathogen Trypanosoma brucei undergoes a complex life cycle in the tsetse fly. Here we introduce the host insect as an expedient model environment for microswimmer research, as it allows examination of microbial motion within a diversified, secluded and yet microscopically tractable space. During their week-long journey through the different microenvironments of the fly´s interior organs, the incessantly swimming trypanosomes cross various barriers and confined surroundings, with concurrently occurring major changes of parasite cell architecture...
August 15, 2017: ELife
https://www.readbyqxmd.com/read/28805589/visual-dysfunction-in-parkinson-s-disease
#20
Richard A Armstrong
This chapter describes the visual problems likely to be encountered in Parkinson's disease (PD) and whether such signs are useful in differentiating the parkinsonian syndromes. Visual dysfunction in PD may involve visual acuity, contrast sensitivity, color discrimination, pupil reactivity, saccadic and pursuit eye movements, motion perception, visual fields, and visual processing speeds. In addition, disturbance of visuospatial orientation, facial recognition problems, rapid eye movement (REM) sleep behavior disorder, and chronic visual hallucinations may be present...
2017: International Review of Neurobiology
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