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https://www.readbyqxmd.com/read/29150860/quality-of-life-outcomes-after-subthalamic-stimulation-in-parkinson-s-disease-depends-on-age
#1
Haidar S Dafsari, Paul Reker, Lisa Stalinski, Monty Silverdale, Alexandra Rizos, Keyoumars Ashkan, Michael T Barbe, Gereon R Fink, Julian Evans, Julia Steffen, Michael Samuel, Till A Dembek, Veerle Visser-Vandewalle, Angelo Antonini, K Ray-Chaudhuri, Pablo Martinez-Martin, Lars Timmermann
OBJECTIVE: The purpose of this study was to investigate how quality of life outcome after bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) in Parkinson's disease (PD) depends on age. METHODS: In this prospective, open-label, multicenter study including 120 PD patients undergoing bilateral STN-DBS, we investigated the PDQuestionnaire-8 (PDQ-8), Unified PD Rating Scale-III, Scales for Outcomes in PD-motor examination, complications, activities of daily living, and levodopa equivalent daily dose preoperatively and at 5 months follow-up...
November 18, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29146650/benefits-and-risks-of-iron-interventions-in-children-brisc-protocol-for-a-three-arm-parallel-group-randomised-controlled-field-trial-in-bangladesh
#2
Mohammed Imrul Hasan, Sheikh Jamal Hossain, Sabine Braat, Michael John Dibley, Jane Fisher, Sally Grantham-McGregor, Fahmida Tofail, Julie A Simpson, Shams Ei Arifeen, Jena Hamadani, Beverley-Ann Biggs, Sant-Rayn Pasricha
INTRODUCTION: Anaemia is a major global health problem affecting about 43% of preschool children globally and 60% of 6-24-month-old children in rural Bangladesh, half of which is attributed to iron deficiency (ID). Although WHO recommends universal supplementation with iron or home fortification with iron-containing multiple micronutrient powders (MMPs) to children under 2 years, evidence for benefits of these interventions on childhood development (a key rationale for these interventions) and harms (especially infection) remains limited...
November 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29144107/safe-return-to-driving-following-severe-acquired-brain-injury-role-of-a-short-neuropsychological-assessment
#3
Donatella Saviola, Antonio DE Tanti, Jessica Conforti, Lucio Posteraro, Alessia Manfredini, Chiara Bagattini, Benedetta Basagni
BACKGROUND: Driving is a complex ability requiring a broad range of motor, cognitive- behavioural and visual skills that may be impaired after severe Acquired Brain Injury (sABI). Resumption of driving is perceived as a major need by patients, being closely linked to personal autonomy, work and social activities. AIM: The objective of this study was to identify a short battery of neuropsychological tests with predictive value with regard to safe return to driving after sABI...
November 16, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29144106/cognitive-reserve-as-a-variable-impacting-the-effectiveness-of-rehabilitation-on-balance-in-parkinson-s-disease
#4
Giulia Piccinini, Isabella Imbimbo, Diego Ricciardi, Daniele Coraci, Claudia Santilli, Maria R Lo Monaco, Claudia Loreti, Maria C Vulpiani, Maria C Silveri, Luca Padua
BACKGROUND: Cognitive reserve (CR) can be considered an active expression of brain resilience in response to damage. Several studies have shown the influence of CR on cognitive impairment and its relationship with cognitive function in Parkinson's disease (PD). AIM: To show if CR influences the effectiveness of balance rehabilitation in PD patients who performed a conventional rehabilitative treatment. DESIGN: Observational longitudinal study...
November 16, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29142089/motor-cognitive-and-functional-declines-contribute-to-a-single-progressive-factor-in-early-hd
#5
Scott A Schobel, Giuseppe Palermo, Peggy Auinger, Jeffrey D Long, Shiyang Ma, Omar S Khwaja, Dylan Trundell, Merit Cudkowicz, Steven Hersch, Cristina Sampaio, E Ray Dorsey, Blair R Leavitt, Karl D Kieburtz, Jeffrey J Sevigny, Douglas R Langbehn, Sarah J Tabrizi
OBJECTIVE: To identify an improved measure of clinical progression in early Huntington disease (HD) using data from prospective observational cohort studies and placebo group data from randomized double-blind clinical trials. METHODS: We studied Unified Huntington Disease Rating Scale (UHDRS) and non-UHDRS clinical measures and brain measures of progressive atrophy in 1,668 individuals with early HD followed up prospectively for up to 30 to 36 months of longitudinal clinical follow-up...
November 15, 2017: Neurology
https://www.readbyqxmd.com/read/29134630/successful-community-discharge-following-postacute-rehabilitation-for-medicare-beneficiaries-analysis-of-a-patient-centered-quality-measure
#6
Michael P Cary, Janet Prvu Bettger, Jessica M Jarvis, Kenneth J Ottenbacher, James E Graham
OBJECTIVE: To determine the sociodemographic and clinical characteristics as well as health services use associated with successful community discharge. DATA SOURCE: Inpatient Rehabilitation Facility-Patient Assessment Instrument and Medicare Provider Analysis and Review files. STUDY DESIGN: We retrospectively examined 167,664 Medicare beneficiaries discharged from inpatient rehabilitation facilities (IRFs) in 2013 to determine the sociodemographic and clinical characteristics as well as health services use associated with successful community discharge...
November 13, 2017: Health Services Research
https://www.readbyqxmd.com/read/29132071/reliability-of-clinically-feasible-dual-task-tests-expanded-timed-get-up-and-go-test-as-a-motor-task-on-young-healthy-individuals
#7
Kaori Tamura, Morgan Kocher, Liana Finer, Nathan Murata, Christopher Stickley
Dual-Task testing has been reported to have a higher sensitivity to deficits associated with concussion; however, the feasibility as a clinical or field test is questionable due to the requirements of laboratory-based equipment. With an overarching goal of exploration of clinically feasible Dual-Task testing options, the specific aims of this study were 1) to evaluate the reliability of Dual-Task testing methods using the Expanded Timed Get-Up-and-Go (ETGUG) paired with Backward Digit Recall (BDR), Serial Seven (SS), and Auditory Pure Switch Task (APST), and 2) to determine the effects of Dual-Task testing on motor and cognitive performance in healthy college-aged individuals...
November 6, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29131457/neurodevelopmental-outcome-of-hiv-exposed-but-uninfected-infants-in-the-mother-and-infants-health-study-cape-town-south-africa
#8
Priscilla E Springer, Amy L Slogrove, Barbara Laughton, Julie A Bettinger, Henriëtte H Saunders, Christopher D Molteno, Mariana Kruger
OBJECTIVES: To compare neurodevelopmental outcomes of HIV-exposed uninfected (HEU) and HIV-unexposed uninfected (HUU) infants in a peri-urban South African population. HEU infants living in Africa face unique biological and environmental risks but uncertainty remains regarding their neurodevelopmen-tal outcome. This is partly due to lack of well-matched HUU comparison groups needed to adjust for confounding factors. METHODS: This was a prospective cohort study of infants enrolled at birth from a low- risk midwife obstetric facility...
November 13, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29130805/rehabilitative-success-after-brain-trauma-by-augmenting-a-subtherapeutic-dose-of-environmental-enrichment-with-galantamine
#9
Patricia B de la Tremblaye, Jody L Wellcome, Benjamin Wells de Witt, Jeffrey P Cheng, Elizabeth R Skidmore, Corina O Bondi, Anthony E Kline
BACKGROUND: Environmental enrichment (EE) confers benefits after traumatic brain injury (TBI) when provided daily for > 6 hours, but not 2 or 4 hours, which more accurately reflects the daily amount of clinical rehabilitation. The lack of benefit with sub-therapeutic EE suggests that augmentation with galantamine (GAL), which enhances cognition after TBI, may be indicated to confer benefits. OBJECTIVE: To test the hypothesis that 2 and 4 hours of EE paired with GAL will provide benefits comparable to 24 hours of EE alone...
November 1, 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/29127484/progress-in-developing-transgenic-monkey-model-for-huntington-s-disease
#10
REVIEW
Brooke R Snyder, Anthony W S Chan
Huntington's disease (HD) is a complex neurodegenerative disorder that has no cure. Although treatments can often be given to relieve symptoms, the neuropathology associated with HD cannot be stopped or reversed. HD is characterized by degeneration of the striatum and associated pathways that leads to impairment in motor and cognitive functions as well as psychiatric disturbances. Although cell and rodent models for HD exist, longitudinal study in a transgenic HD nonhuman primate (i.e., rhesus macaque; HD monkeys) shows high similarity in its progression with human patients...
November 10, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29127079/effect-of-acupuncture-and-chinese-herbal-medicine-on-subacute-stroke-outcomes-a-single-centre-randomised-controlled-trial
#11
Jianqiao Fang, Crystal Lynn Keeler, Lifang Chen, Ruijie Ma, Chao Wang, Shouyu Xu
OBJECTIVE: To determine whether integrative medicine, combining acupuncture and Chinese herbal medicine with conventional rehabilitation during subacute stroke, is an effective comprehensive rehabilitation strategy for daily life activities, neurological deficits, motor dysfunction, cognitive impairment and depression. DESIGN: Randomised controlled trial: patients were randomly assigned to a conventional rehabilitation (CR) group or an integrative medicine rehabilitation (IMR) group with CR plus acupuncture and Chinese herbal medicine...
November 10, 2017: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
https://www.readbyqxmd.com/read/29124959/speech-therapy-in-adolescents-with-down-syndrome-in-pursuit-of-communication-as-a-fundamental-human-right
#12
Susan Rvachew, Marla Folden
PURPOSE: The achievement of speech intelligibility by persons with Down syndrome facilitates their participation in society. Denial of speech therapy services by virtue of low cognitive skills is a violation of their fundamental human rights as proclaimed in the Universal Declaration of Human Rights in general and in Article 19 in particular. Here, we describe the differential response of an adolescent with Down syndrome to three speech therapy interventions and demonstrate the use of a single subject randomisation design to identify effective treatments for children with complex communication disorders...
November 10, 2017: International Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/29123384/functional-outcomes-by-age-after-inpatient-stroke-rehabilitation-in-saudi-arabia
#13
Saad M Bindawas, Vishal Vennu, Hussam Mawajdeh, Hisham Alhaidary
Background: Among various risk factors, age has been identified as a nonmodifiable risk factor for stroke that influences functional outcomes after inpatient stroke rehabilitation in the developed world as well as in Saudi Arabia (SA). The demand for inpatient stroke rehabilitation services increases with population aging and stroke incidence; however, these services are limited in SA. Objective: To examine functional outcomes by age after inpatient stroke rehabilitation in SA...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29120916/impulsivity-in-personality-disorders-current-views-and-future-directions
#14
Catherine McHugh, Sivasankaran Balaratnasingam
PURPOSE OF REVIEW: Impulsivity is considered a trans-diagnostic feature of many mental disorders, yet our understanding of the concept and approaches to measurement have evolved significantly with advances in neuroimaging. This review will provide an overview of impulsivity as it is currently understood, its association with personality disorder and implications for treatment. RECENT FINDINGS: Impulsivity is now considered to involve failure of inhibitory control, either motor or cognitive, and deficits of the reward valuation system...
November 7, 2017: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/29119593/prediction-of-cognitive-worsening-in-de-novo-parkinson-s-disease-clinical-use-of-biomarkers
#15
Dario Arnaldi, Fabrizio De Carli, Francesco Famà, Andrea Brugnolo, Nicola Girtler, Agnese Picco, Matteo Pardini, Jennifer Accardo, Luca Proietti, Federico Massa, Matteo Bauckneht, Silvia Morbelli, Gianmario Sambuceti, Flavio Nobili
BACKGROUND: Cognitive impairment is a frequent and disabling feature of Parkinson's disease. Identifying the factors able to predict cognitive worsening since the early stage may improve disease management. The objective of this study was to define the best predictors of future cognitive worsening in a group of patients with newly diagnosed PD and to propose cutoff values potentially useful at the individual level. METHODS: Fifty-four consecutive drug-naive patients with de novo PD were prospectively evaluated by clinical and neuropsychological assessment, resting EEG, and (123) I-FP-CIT-SPECT and clinically classified into mainly motor, diffuse/malignant, and intermediate PD subtypes; they were then followed up for an average of 5 years...
November 9, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29119100/motoric-cognitive-risk-syndrome-predictor-of-dementia-and-age-related-negative-outcomes
#16
REVIEW
Jagadish K Chhetri, Piu Chan, Bruno Vellas, Matteo Cesari
Cognitive disorders represent a leading cause of disability in the aging population, of which dementia has the highest global burden. Early signs of dementia such as slow gait and memory complaints are known to present well before the overt manifestation of the disease. Motoric cognitive risk (MCR) syndrome characterized by the simultaneous presence of gait disturbances and memory complaints in older subjects has been proposed to study the close interactions between the physical and cognitive domains as well as a possible approach to identify individuals at increased risk of dementia...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29113755/early-developmental-trajectories-of-preterm-infants
#17
Maya Yaari, David Mankuta, Ayelet Harel-Gadassi, Edwa Friedlander, Benjamin Bar-Oz, Smadar Eventov-Friedman, Nimrod Maniv, David Zucker, Nurit Yirmiya
BACKGROUND AND OBJECTIVES: Preterm infants are at risk for neuro-developmental impairments and atypical developmental trajectories. The aims of this study were to delineate early developmental trajectories of preterm and full-term infants. METHODS: The cognitive, language, and motor development of 149 infants - 19 extremely preterm (EPT), 34 very preterm (VPT), 57 moderately preterm (MPT), and 39 full-term (FT) - was evaluated using Mullen Scales at 1, 4, 8, 12, and 18 months...
November 4, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29113572/effects-of-an-individual-12-week-community-located-start-to-run-program-on-physical-capacity-walking-fatigue-cognitive-function-brain-volumes-and-structures-in-persons-with-multiple-sclerosis
#18
Peter Feys, Lousin Moumdjian, Florian Van Halewyck, Inez Wens, Bert O Eijnde, Bart Van Wijmeersch, Veronica Popescu, Paul Van Asch
BACKGROUND: Exercise therapy studies in persons with multiple sclerosis (pwMS) primarily focused on motor outcomes in mid disease stage, while cognitive function and neural correlates were only limitedly addressed. OBJECTIVES: This pragmatic randomized controlled study investigated the effects of a remotely supervised community-located "start-to-run" program on physical and cognitive function, fatigue, quality of life, brain volume, and connectivity. METHOD: In all, 42 pwMS were randomized to either experimental (EXP) or waiting list control (WLC) group...
November 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29112069/neuropsychological-performance-in-african-children-with-hiv-enrolled-in-a-multi-site-anti-retroviral-clinical-trial
#19
Michael J Boivin, Linda Barlow-Mosha, Miriam Chernoff, Barbara Laughton, Bonnie Zimmer, Celeste Joyce, Mutsa Bwakura-Dangarembizi, Mmule Ratswana, Nasreen Abrahams, Lee Fairlie, Hermien Gous, Portia Kamthunzi, Katie McCarthy, Itziar Familiar-Lopez, Patrick Jean-Phillippe, Joan Coetzee, Avy Violari, Mark Cotton, Paul Palumbo
OBJECTIVE & DESIGN: Children with HIV infection (HIV+) are at neuropsychological risk, but few studies have evaluated this at multiple sites in low and middle income countries (LMICs). We compared neuropsychological outcomes at enrollment (>5 yrs age) among HIV+, HIV-uninfected perinatally-exposed (HEU), and HIV unexposed (HU) children from 4 sub-Saharan countries. METHODS: IMPAACT P1060 compared Nevirapine (NVP) versus Lopinavir/Ritonavir (LPVr)-based ART in HIV-infected children 6 to 35 months of age...
November 2, 2017: AIDS
https://www.readbyqxmd.com/read/29112063/sex-based-differences-in-neurocognitive-functioning-in-hiv-infected-young-adults
#20
Ruxandra Burlacu, Anya Umlauf, Anca Luca, Sara Gianella, Roxana Radoi, Simona M Ruta, Thomas D Marcotte, Luminita Ene, Cristian L Achim
INTRODUCTION: Sex differences in cognition of HIV positive (HIV+) patients are controversial. We aimed to investigate the relationship between cognition, HIV status, and sex, in a highly homogenous cohort of young Romanians parenterally infected during early childhood. METHODS: 250 HIV+ participants were compared to age-matched HIV negative (HIV-) controls (n = 72) in a cross-sectional study. After standardized neurocognitive, psychological testing and medical evaluation, linear regression was used to assess the effect of sex and HIV on neurocognitive outcomes...
November 2, 2017: AIDS
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