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https://www.readbyqxmd.com/read/29333611/cognitive-dysfunction-after-generalized-tonic-clonic-status-epilepticus-in-adults
#1
K N Power, A Gramstad, N E Gilhus, K O Hufthammer, B A Engelsen
OBJECTIVES: Generalized tonic-clonic status epilepticus (GTC-SE) is considered a risk for cognitive impairment. Research with standardized tools is scarce and non-conclusive. We systematically assessed short-term and long-term cognitive function after GTC-SE. MATERIALS AND METHODS: Thirty-three patients were tested after the clinical post-ictal phase of GTC-SE (timepoint 1) and again after 1 year (timepoint 2). Twenty controls were examined with the same tests...
January 14, 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29329670/motor-skill-interventions-in-children-with-developmental-coordination-disorder-a-systematic-review-and-meta-analysis
#2
REVIEW
Jane J Yu, Cindy H P Sit, Angus F Burnett
OBJECTIVES: To determine the characteristics and effectiveness of motor skill interventions in children with developmental coordination disorder (DCD) and to identify potential moderators of training effects using meta-analysis. DATA SOURCES: A search was conducted in six databases (CINAHL Plus, Cochrane Library, Embase, Eric, PsycInfo, and PubMed) for papers published between 1995 and August 2017 using search items which were grouped in three components (motor skill interventions, DCD, and age group of interest)...
January 9, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29327599/motor-skills-cognition-and-work-performance-of-people-with-severe-mental-illness
#3
Lena Lipskaya-Velikovsky, Dikla Elgerisi, Adam Easterbrook, Navah Z Ratzon
PURPOSE: Employment offers many benefits to people with mental illness, yet their employment rate is much lower than that of the general population. We investigated the effect of work-related motor skills, neurocognition, and job attitudes on the work performance of people with mental illness, comparing those working in sheltered workshops, with controls working in similar jobs. METHODS: Twenty-nine adults with severe mental illness and 27 controls matched by gender and age were enrolled into the study using convenience sampling...
January 12, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29324862/taking-two-to-tango-fmri-analysis-of-improvised-joint-action-with-physical-contact
#4
Léa A S Chauvigné, Michel Belyk, Steven Brown
Many forms of joint action involve physical coupling between the participants, such as when moving a sofa together or dancing a tango. We report the results of a novel two-person functional MRI study in which trained couple dancers engaged in bimanual contact with an experimenter standing next to the bore of the magnet, and in which the two alternated between being the leader and the follower of joint improvised movements. Leading showed a general pattern of self-orientation, being associated with brain areas involved in motor planning, navigation, sequencing, action monitoring, and error correction...
2018: PloS One
https://www.readbyqxmd.com/read/29322861/community-mobility-after-stroke-a-systematic-review
#5
Steven Wesselhoff, Timothy A Hanke, Christian C Evans
Background Stroke is the leading cause of severe disability and many survivors report long-term physical or cognitive impairments that may impact their ability to achieve community mobility (CM). PURPOSE: To determine the extent to which people with chronic stroke achieve CM compared to age-matched norms or non-neurologically impaired controls. Methods The StrokEDGE outcome measures were searched to identify validated tools that included >25% of items addressing CM. MEDLINE, CINAHL, Google Scholar, PubMed, PEDro and the Cochrane databases were searched from 2001 to 2015 with the identified outcome measures cross-referenced against search terms related to stroke and CM...
January 11, 2018: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/29321468/length-of-stay-and-functional-outcomes-among-patients-with-stroke-discharged-from-an-inpatient-rehabilitation-facility-in-saudi-arabia
#6
Saad M Bindawas, Vishal Vennu, Hussam Mawajdeh, Hisham M Alhaidary, Emad Moftah
BACKGROUND In many countries, the length of stay (LOS) for inpatient rehabilitation following stroke has gradually decreased. It is unclear whether this trend is associated with differences in functional outcomes, especially in developing countries. This study aimed to examine associations between LOS and functional outcomes among patients with stroke discharged from an inpatient rehabilitation facility in Saudi Arabia. MATERIAL AND METHODS This retrospective study included all patients (N=409) aged ≥18 years who were admitted to an inpatient rehabilitation for stroke during 2008-2014...
January 11, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29321141/efficacy-of-intensive-multidisciplinary-rehabilitation-in-parkinson-s-disease-a-randomised-controlled-study
#7
Davide Ferrazzoli, Paola Ortelli, Ilaria Zivi, Veronica Cian, Elisa Urso, Maria Felice Ghilardi, Roberto Maestri, Giuseppe Frazzitta
OBJECTIVE: To evaluate whether a 4-week multidisciplinary, aerobic, motor-cognitive and intensive rehabilitation treatment (MIRT) improves the quality of life (QoL) of patients with Parkinson's disease (PD), in the short-term and long-term period. METHODS: This is a prospective, parallel-group, single-centre, single-blind, randomised clinical trial (ClinicalTrials.gov NCT02756676). 186 patients with PD, assigned to experimental group, underwent MIRT; conversely, 48 patients, assigned to control group, did not receive rehabilitation...
January 10, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29317418/home-polygraphic-recording-with-telemedicine-monitoring-for-diagnosis-and-treatment-of-sleep-apnoea-in-stroke-hopes-study-study-protocol-for-a-single-blind-randomised-controlled-trial
#8
Stefan Thomas Kotzian, Angela Schwarzinger, Sandra Haider, Bernd Saletu, Josef Spatt, Michael Timothy Saletu
INTRODUCTION: Meta-analyses report that more than 50% of patients who had a stroke suffer from moderate to severe sleep apnoea (SA), with adherence rates to positive airway pressure (PAP) therapy of only 30%. The primary objective of this study is to determine whether PAP adherence in patients who had a stroke with obstructive sleep apnoea (OSA) can be improved by a PAP training strategy during inhospital rehabilitation combined with a telemedicine monitoring system after discharge. Further objectives are (1) to compare the validity of a non-attended level-III polygraphy with that of a level-II polysomnography (PSG) in the diagnosis of SA, (2) to compare the validity of an apnoea-hypopnoea index (AHI) yielded by the PAP device with that obtained during PSG, (3) to determine changes in nocturnal systolic blood pressure (BP) due to PAP therapy with the pulse transit time (PTT) method and (4) to assess the impact of telemonitored PAP therapy on neurorehabilitation outcome parameters...
January 9, 2018: BMJ Open
https://www.readbyqxmd.com/read/29306185/pre-stroke-employment-results-in-better-patient-reported-outcomes-after-minor-stroke-short-title-functional-outcomes-after-minor-stroke
#9
Elisabeth B Marsh, Erin Lawrence, Argye E Hillis, Karen Chen, Rebecca F Gottesman, Rafael H Llinas
OBJECTIVE: Individuals with "minor stroke" lack a dense hemiparesis or aphasia; however, commonly endorse persistent cognitive and motor problems despite low NIHSS scores. They also report problems with mood, energy, and the ability to think clearly that are less well characterized. Socioeconomic factors and stroke severity can influence patient-reported outcomes. In this study we explore patient-reported outcomes and the influence of these factors after minor stroke. PATIENTS AND METHODS: Patients returning to clinic post-stroke with an NIHSS of ≤ 4 were administered a scale to quantify problems with daily activities and resulting functional burden, along with measures of fatigue and depression...
December 27, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29304748/revisiting-the-link-between-cognitive-decline-and-masticatory-dysfunction
#10
Chia-Shu Lin
Age-related decline in cognitive functions and dementia are major challenges in geriatric healthcare. Accumulating evidence from clinical, epidemiological and animal research suggests that tooth loss may be a risk factor for the decline of cognitive functions. This issue highlights the role of the brain-stomatognathic axis in geriatric medicine. Whether input from the stomatognathic apparatus can affect the brain remains an open debate. By revisiting the evidence published in the past five years, we argue that the hypothesis regarding the association between cognitive decline and masticatory dysfunction should be carefully interpreted...
January 5, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29303891/short-term-neurodevelopmental-outcome-in-congenital-diaphragmatic-hernia-the-impact-of-extracorporeal-membrane-oxygenation-and-timing-of-repair
#11
Enrico Danzer, Casey Hoffman, Jo Ann D'Agostino, James T Connelly, Lindsay N Waqar, Marsha Gerdes, Judy Bernbaum, Natalie E Rintoul, Lisa M Herkert, William H Peranteau, Alan W Flake, N Scott Adzick, Holly L Hedrick
OBJECTIVES: The purpose of this study was to assess the need and timing of extracorporeal membrane oxygenation in relation to congenital diaphragmatic hernia repair as modifiers of short-term neurodevelopmental outcomes. DESIGN: Retrospective study. SETTING: A specialized tertiary care center. PATIENTS: Between June 2004 and February 2016, a total of 212 congenital diaphragmatic hernia survivors enrolled in our follow-up program...
January 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29298678/the-brainfit-study-efficacy-of-cognitive-training-and-exergaming-in-pediatric-cancer-survivors-a-randomized-controlled-trial
#12
Valentin Benzing, Noëmi Eggenberger, Janine Spitzhüttl, Valerie Siegwart, Manuela Pastore-Wapp, Claus Kiefer, Nedelina Slavova, Michael Grotzer, Theda Heinks, Mirko Schmidt, Achim Conzelmann, Maja Steinlin, Regula Everts, Kurt Leibundgut
BACKGROUND: Cancer survival comes at a price: pediatric cancer survivors bear a high risk for a wide range of cognitive difficulties. Therefore, interventions targeting these difficulties are required. The aim of the present clinical trial is to extend empirical evidence about efficacy of cognitive and physical training in pediatric cancer survivors. It is hypothesized that early cognitive and physical interventions affect the remediation of pediatric cancer survivors in terms of improved executive functions (primary outcome)...
January 3, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29298550/maximising-recovery-from-aphasia-with-central-and-peripheral-agraphia-the-benefit-of-sequential-treatments
#13
Pélagie M Beeson, Chelsea Bayley, Christine Shultz, Kindle Rising
Maximal recovery from acquired language impairment may require progression from one behavioural treatment protocol to the next in order to build upon residual and relearned cognitive-linguistic and sensory-motor processes. We present a five-stage treatment sequence that was initiated at one year post stroke in a woman with acquired impairments of spoken and written language. As is typical of individuals with left perisylvian damage, she demonstrated marked impairment of phonological retrieval and sublexical phonology, but she also faced additional challenges due to impaired letter shape knowledge and visual attention...
January 3, 2018: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/29288912/prediction-of-three-year-outcomes-using-the-bayley-iii-for-surgical-cardiac-and-healthy-australian-infants-at-one-year-of-age
#14
Natalie Fairbairn, Claire Galea, Alison Loughran-Fowlds, Antoinette Hodge, Nadia Badawi, Karen Walker
BACKGROUND: Previous predictive research has predominantly focussed on infants who are preterm, low birth weight, who have a specific condition or who have undergone a specific procedure. AIM: This study investigated the ability of outcomes at one year of age to predict outcomes at three years using the Bayley-III for infants who have undergone early major cardiac surgery (CS) or non-cardiac (NC) surgery and their healthy peers. STUDY DESIGN: Participants who were part of the Development After Infant Surgery (DAISy) study who had complete Bayley-III assessments at one and three years of age were included in the analyses...
December 27, 2017: Early Human Development
https://www.readbyqxmd.com/read/29287180/neurocognitive-and-physical-functioning-in-the-seveso-women-s-health-study
#15
Jennifer Ames, Marcella Warner, Paolo Brambilla, Paolo Mocarelli, William A Satariano, Brenda Eskenazi
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is neurotoxic in animals but few studies have investigated its effects on the human brain. Related dioxin-like compounds have been linked to poorer cognitive and motor function in older adults, with effects more pronounced in women, perhaps due to the loss of neuro-protective estrogen in menopause. On 10 July 1976, a chemical explosion in Seveso, Italy, resulted in one of the highest known residential exposures to TCDD. In 1996, we initiated the Seveso Women's Health Study, a retrospective cohort study of the health of the women who were newborn to 40 years old in 1976...
December 26, 2017: Environmental Research
https://www.readbyqxmd.com/read/29286928/long-term-neurodevelopment-outcome-of-caffeine-versus-aminophylline-therapy-for-apnea-of-prematurity
#16
S Khurana, M Shivakumar, G V Sujith Kumar Reddy, P Jayashree, Y Ramesh Bhat, L E S Lewis
OBJECTIVE: Methylxanthines are the most commonly prescribed drug in neonatal setups. However, Clinicians show indecision in choosing the right agent for Apnea of Prematurity in most of the developing countries. Present study aimed to compare rate of mortality and survival with normal neurodevelopment outcome at 18 to 24 months of corrected age, between Caffeine- and Aminophylline-treated infants for apnea of prematurity. METHODS: 240 infants were randomly allocated to caffeine and aminophylline for apnea of prematurity during February 2012 to January 2015...
2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29285982/effects-of-veliparib-on-microglial-activation-and-functional-outcomes-following-traumatic-brain-injury-in-the-rat-and-pig
#17
Karen Irvine, Robin Bishop, Seok Joon Won, Jianguo Xu, Katherine Hamel, Valerie Coppes, Pardeep Singh, Andrew Sondag, Eric Rome, Jayinee Basu, Giordano Santos, S Scott Panter, Raymond Swanson
The inflammation response induced by brain trauma can impair recovery. This response requires several hours to fully develop, and thus provides a clinically relevant therapeutic window of opportunity. Poly(ADP-ribose) polymerase inhibitors suppress inflammatory responses, including brain microglial activation. Here we evaluated delayed treatment with veliparib, a poly(ADP-ribose) polymerase inhibitor currently in clinical trials as a cancer therapeutic, in rats and pigs subjected to controlled cortical impact (CCI)...
December 29, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29278286/autonomic-dysfunction-in-parkinson-s-disease-a-prospective-cohort-study
#18
Aristide Merola, Alberto Romagnolo, Michela Rosso, Ritika Suri, Zoe Berndt, Simona Maule, Leonardo Lopiano, Alberto J Espay
BACKGROUND: Dysautonomia is a frequent and disabling complication of PD, with an estimated prevalence of 30-40% and a significant impact on the quality of life. OBJECTIVES: To evaluate the rate of progression of dysautonomia and, in particular, orthostatic hypotension, in a cohort of unselected PD patients, and assess the extent to which the progression of dysautonomia affects activities of daily living, health-related quality of life, and health care utilization in PD...
December 26, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29276008/altered-kinematics-of-arm-swing-in-parkinson-s-disease-patients-indicates-declines-in-gait-under-dual-task-conditions
#19
Elise I Baron, Mandy Miller Koop, Matthew C Streicher, Anson B Rosenfeldt, Jay L Alberts
OBJECTIVE: Declines in simultaneous performance of a cognitive and motor task are present in Parkinson's disease due to compromised basal ganglia function related to information processing. The aim of this project was to determine if biomechanical measures of arm swing could be used as a marker of gait function under dual-task conditions in Parkinson's disease patients. METHODS: Twenty-three patients with Parkinson's disease completed single and dual-task cognitive-motor tests while walking on a treadmill at a self-selected rate...
December 19, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29275071/very-preterm-born-children-at-early-school-age-healthcare-therapies-and-educational-provisions
#20
S van Veen, C S H Aarnoudse-Moens, J Oosterlaan, L van Sonderen, T R de Haan, A H van Kaam, A G van Wassenaer-Leemhuis
AIM: To explore changes in motor and cognitive outcomes in very preterm (VP; gestational age<30weeks) born children between ages five and six years, and to determine whether changes in these outcomes were associated with the use of healthcare therapies and educational provisions. STUDY DESIGN: Single-center observational cohort study. Five-year-old VP born children of a one-year-cohort of our neonatal follow-up program (N=90) were invited for re-assessments at age six...
December 21, 2017: Early Human Development
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