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https://www.readbyqxmd.com/read/28726034/mentally-stimulating-activities-associate-with-better-cognitive-performance-in-parkinson-disease
#1
Jeffrey L B Bohnen, Martijn L T M Müller, Jacob Haugen, Nicolaas I Bohnen
Subjects at risk of dementia benefit from participation in mentally stimulating activities, but no prior studies have investigated similar associations in Parkinson disease (PD). The aim of this study was to investigate the relationship between times spent engaging in mentally stimulating activities and cognitive functions in PD while accounting for the degree of primary neurodegenerations. PD patients (N = 41, 33 males; age 68.5 ± 7.2; Hoehn and Yahr stage 2.6 ± 0.6) completed the Community Health Activities Model Program for Seniors questionnaire, mini-mental state examination (MMSE), and [(11)C]dihydrotetrabenazine dopaminergic and [(11)C]piperidinyl propionate acetylcholinesterase PET imaging...
July 19, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28722635/early-life-inflammation-and-neurodevelopmental-outcome-in-bangladeshi-infants-growing-up-in-adversity
#2
Nona M Jiang, Fahmida Tofail, Jennie Z Ma, Rashidul Haque, Beth Kirkpatrick, Charles A Nelson, William A Petri
Exposure to profound adversity can negatively affect the neurodevelopment of children, but biologic mechanisms that underlie this association remain unknown. We sought to determine whether elevated levels of the inflammatory markers C-reactive protein (CRP) and soluble CD14 (sCD14) are associated with neurodevelopmental outcomes in Bangladeshi children. A total of 422 infant-mother pairs from an urban slum in Dhaka, Bangladesh, were enrolled at birth and followed prospectively. Inflammation was measured with sCD14, interleukin (IL)-1β, and IL-6 at 18 weeks, and CRP at 6, 18, 40, and 53 weeks...
July 17, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28719298/cognitive-outcomes-and-psychiatric-symptoms-of-retinopathy-positive-cerebral-malaria-cohort-description-and-baseline-results
#3
Rachel Brim, Sebastian Mboma, Margaret Semrud-Clikeman, Sam Kampondeni, Jed Magen, Terrie Taylor, John Langfitt
Cerebral malaria (CM) is a common cause of death and disability among children in sub-Saharan Africa. Many prior studies of neuropsychiatric morbidity have been limited by a cross-sectional design or a short duration of follow-up. Most have included subjects who may have presented with coma due to a disease process other than CM. No studies have assessed the relationship between magnetic resonance imaging (MRI) findings and long-term outcomes. The Cognitive Outcomes and Psychiatric symptoms of retinopathy-positive CM (COPS) cohort is the first large (N = 221) prospectively recruited cohort of stringently defined cases of CM and hospital-based, age-matched, non-CM controls in whom cognitive and psychiatric outcomes are assessed with standardized measures semi-annually for up to 5 years...
July 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28719076/multimodal-image-analysis-of-clinical-influences-on-preterm-brain-development
#4
Gareth Ball, Paul Aljabar, Phumza Nongena, Nigel Kennea, Nuria Gonzalez-Cinca, Shona Falconer, Andrew T M Chew, Nicholas Harper, Julia Wurie, Mary A Rutherford, Serena J Counsell, A David Edwards
Objective Premature birth is associated with numerous complex abnormalities of white and grey matter and a high incidence of long-term neurocognitive impairment. An integrated understanding of these abnormalities and their association with clinical events is lacking. The aim of this study was to identify specific patterns of abnormal cerebral development and their antenatal and postnatal antecedents. Methods In a prospective cohort of 449 infants (226 male), we performed a multi-variate and data-driven analysis combining multiple imaging modalities...
July 18, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28716072/effect-of-prenatal-exposure-to-maternal-cortisol-and-psychological-distress-on-infant-development-in-bengaluru-southern-india-a-prospective-cohort-study
#5
Anita Nath, Gudlavalleti Venkata Satyanarayana Murthy, Giridhara R Babu, Gian Carlo Di Renzo
BACKGROUND: The mental health status of a pregnant woman and its consequent impact on foetal well being is not given much importance compared to the risk imposed by obstetric complications and medical conditions. Maternal psychological distress is a major public health problem and needs timely detection and intervention to prevent any adverse pregnancy outcome. There is ample evidence from literature that justifies the association of prenatal maternal mental stress and elevated cortisol with delayed infant motor and cognitive development; evidence from India being rather limited...
July 17, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28712602/anaplerotic-therapy-in-propionic-acidemia
#6
Nicola Longo, Leisa B Price, Eduard Gappmaier, Nancy L Cantor, Sharon L Ernst, Carrie Bailey, Marzia Pasquali
BACKGROUND: Propionic acidemia is a rare metabolic disorder caused by a deficiency of propionyl- CoA carboxylase, the enzyme converting propionyl-CoA to methylmalonyl-CoA that subsequently enters the citric acid cycle as succinyl-CoA. Patients with propionic acidemia cannot metabolize propionic acid, which combines with oxaloacetate to form methylcitric acid. This, with the defective supply of succinyl-CoA, may lead to a deficiency in citric acid cycle intermediates. PURPOSE: The objective of this study was to determine whether supplements with glutamine (400mg/kg per day), citrate (7...
July 12, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/28711192/predictors-of-anxiety-in-early-stage-parkinson-s-disease-results-from-the-first-two-years-of-a-prospective-cohort-study
#7
Sonja Rutten, Peter M van der Ven, Daniel Weintraub, Gregory M Pontone, Albert F G Leentjens, Henk W Berendse, Ysbrand D van der Werf, Odile A van den Heuvel
AIM: Anxiety has a negative impact on daily functioning and quality of life in patients with Parkinson's disease (PD). This study aims at assessing which sociodemographic and clinical characteristics predict the course of anxiety in early PD. METHODS: The participants of this two-year prospective cohort study were recently diagnosed PD patients not receiving psychiatric medications or dopamine replacement therapy at baseline. Assessments were performed annually after baseline...
July 5, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28709631/neurodevelopmental-profiles-of-children-with-congenital-heart-disease-at-school-age
#8
Nadja Naef, Rabia Liamlahi, Ingrid Beck, Vera Bernet, Hitendu Dave, Walter Knirsch, Beatrice Latal
OBJECTIVES: To assess 6-year neurodevelopmental outcomes in a current cohort of children with congenital heart disease (CHD) who underwent cardiopulmonary bypass surgery (CPB), and to determine risk factors for adverse outcomes. STUDY DESIGN: Outcomes were examined in 233 prospectively enrolled children with CHD (including 64 with a recognized genetic disorder) who underwent CPB between 2004 and 2009. Follow-up assessment included standardized neurologic, motor, and cognitive tests...
July 11, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28707213/non-dominant-hand-use-increases-completion-time-on-part-b-of-the-trail-making-test-but-not-on-part-a
#9
Laura Klaming, Björn N S Vlaskamp
The Trail Making Test (TMT) is used in neuropsychological clinical practice to assess aspects of attention and executive function. The test consists of two parts (A and B) and requires drawing a trail between elements. Many patients are assessed with their non-dominant hand because of motor dysfunction that prevents them from using their dominant hand. Since drawing with the non-dominant hand is not an automatic task for many people, we explored the effect of hand use on TMT performance. The TMT was administered digitally in order to analyze new outcome measures in addition to total completion time...
July 13, 2017: Behavior Research Methods
https://www.readbyqxmd.com/read/28706500/executive-functions-do-not-mediate-prospective-relations-between-indices-of-physical-activity-and-academic-performance-the-active-smarter-kids-ask-study
#10
Katrine N Aadland, Yngvar Ommundsen, Eivind Aadland, Kolbjørn S Brønnick, Arne Lervåg, Geir K Resaland, Vegard F Moe
Changes in cognitive function induced by physical activity have been proposed as a mechanism for the link between physical activity and academic performance. The aim of this study was to investigate if executive function mediated the prospective relations between indices of physical activity and academic performance in a sample of 10-year-old Norwegian children. The study included 1,129 children participating in the Active Smarter Kids (ASK) trial, followed over 7 months. Structural equation modeling (SEM) with a latent variable of executive function (measuring inhibition, working memory, and cognitive flexibility) was used in the analyses...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28706091/predict-cp-study-protocol-of-implementation-of-comprehensive-surveillance-to-predict-outcomes-for-school-aged-children-with-cerebral-palsy
#11
Roslyn N Boyd, Peter Sw Davies, Jenny Ziviani, Stewart Trost, Lee Barber, Robert Ware, Stephen Rose, Koa Whittingham, Leanne Sakzewski, Kristie Bell, Christopher Carty, Steven Obst, Katherine Benfer, Sarah Reedman, Priya Edwards, Megan Kentish, Lisa Copeland, Kelly Weir, Camilla Davenport, Denise Brooks, Alan Coulthard, Rebecca Pelekanos, Andrea Guzzetta, Simona Fiori, Meredith Wynter, Christine Finn, Andrea Burgess, Kym Morris, John Walsh, Owen Lloyd, Jennifer A Whitty, Paul A Scuffham
OBJECTIVES: Cerebral palsy (CP) remains the world's most common childhood physical disability with total annual costs of care and lost well-being of $A3.87b. The PREDICT-CP (NHMRC 1077257 Partnership Project: Comprehensive surveillance to PREDICT outcomes for school age children with CP) study will investigate the influence of brain structure, body composition, dietary intake, oropharyngeal function, habitual physical activity, musculoskeletal development (hip status, bone health) and muscle performance on motor attainment, cognition, executive function, communication, participation, quality of life and related health resource use costs...
July 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/28704672/anthropometric-measures-at-birth-and-early-childhood-are-associated-with-neurodevelopmental-outcomes-among-bangladeshi-children-aged-2-3years
#12
Jane J Lee, Kush Kapur, Ema G Rodrigues, Md Omar Sharif Ibne Hasan, Quazi Quamruzzaman, Robert O Wright, David C Bellinger, David C Christiani, Maitreyi Mazumdar
Among a cohort of children located in rural areas of Bangladesh affected by high levels of exposure to environmental metals, we investigated the associations between anthropometric measures, growth trajectory, and neurodevelopment at age 20-40months. Our study population included mothers and their children who participated in a longitudinal birth cohort study that took in place in the Pabna and Sirajdikhan areas of Bangladesh. Anthropometric measures including weight, length, and head circumference were measured at birth, age 12months, and age 20-40months...
July 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28701989/supramodal-enhancement-of-auditory-perceptual-and-cognitive-learning-by-video-game-playing
#13
Yu-Xuan Zhang, Ding-Lan Tang, David R Moore, Sygal Amitay
Medical rehabilitation involving behavioral training can produce highly successful outcomes, but those successes are obtained at the cost of long periods of often tedious training, reducing compliance. By contrast, arcade-style video games can be entertaining and highly motivating. We examine here the impact of video game play on contiguous perceptual training. We alternated several periods of auditory pure-tone frequency discrimination (FD) with the popular spatial visual-motor game Tetris played in silence...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28698326/miyoga-a-randomised-controlled-trial-of-a-mindfulness-movement-programme-based-on-hatha-yoga-principles-for-children-with-cerebral-palsy-a-study-protocol
#14
Catherine Mak, Koa Whittingham, Ross Cunnington, Roslyn N Boyd
INTRODUCTION: Cerebral palsy (CP) is the most common childhood physical disability, with life-long impacts for 1.77 in 1000 children. Although CP is primarily a physical disability, children with CP have an increased risk of experiencing cognitive difficulties, particularly attention and executive function deficits. Impairment in cognitive abilities can lead to subsequent impairment in independent functioning, education, employment and interpersonal relationships. This paper reports the protocol of a randomised controlled trial of a novel family-centred lifestyle intervention based on mindfulness and hatha yoga principles (MiYoga)...
July 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28698150/freezing-of-gait-is-associated-with-cognitive-impairment-in-patients-with-parkinson-disease
#15
Zhiwen Yao, Yuan Shao, Xiang Han
OBJECTIVE: To explore whether the cognitive impairment is correlated with freezing of gait (FOG) in patients with Parkinson disease (PD). METHODS: A total of 186 patients with Parkinson disease (104 patients with FOG and 82 patients with no clinical history of freezing behavior) and 125 healthy individuals were selected for this study. Neuropsychological assessments, including the scales for outcomes in Parkinson disease cognition, unified Parkinson's disease rating scale, and Hamilton depression/anxiety rating scale etc...
July 8, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28698031/comparable-impediment-of-cognitive-function-in-female-and-male-rats-subsequent-to-daily-administration-of-haloperidol-after-traumatic-brain-injury
#16
Kristin E Free, Anna M Greene, Corina O Bondi, Naima Lajud, Patricia B de la Tremblaye, Anthony E Kline
Antipsychotic drugs, such as haloperidol (HAL), are prescribed in the clinic to manage traumatic brain injury (TBI)-induced agitation. While preclinical studies have consistently shown that once-daily administration of HAL hinders functional recovery after TBI in male rats, its effects in females are unknown. Hence, the objective of this study was to directly compare neurobehavioral and histological outcomes in both sexes to determine whether the reported deleterious effects of HAL extend to females. Anesthetized adult female and male rats received either a controlled cortical impact (CCI) or sham injury and then were randomly assigned to a dosing regimen of HAL (0...
July 8, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28697816/association-between-maternal-vitamin-d-status-in-pregnancy-and-neurodevelopmental-outcomes-in-childhood-results-from-the-avon-longitudinal-study-of-parents-and-children-alspac
#17
Andrea L Darling, Margaret P Rayman, Colin D Steer, Jean Golding, Susan A Lanham-New, Sarah C Bath
Seafood intake in pregnancy has been positively associated with childhood cognitive outcomes which could potentially relate to the high vitamin D content of oily fish. However, whether higher maternal vitamin D status (serum 25-hydroxyvitamin D (25(OH)D)) in pregnancy is associated with a reduced risk of offspring suboptimal neurodevelopmental outcomes is unclear. A total of 7065 mother-child pairs were studied from the Avon Longitudinal Study of Parents and Children cohort who had data for both serum total 25(OH)D concentration in pregnancy and at least one measure of offspring neurodevelopment (pre-school development at 6-42 months; 'Strengths and Difficulties Questionnaire' scores at 7 years; intelligence quotient (IQ) at 8 years; reading ability at 9 years)...
July 12, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28694613/cognitive-and-functional-outcomes-following-inpatient-rehabilitation-in-patients-with-acquired-brain-injury-a-prospective-follow-up-study
#18
Maitreyi Patil, Anupam Gupta, Meeka Khanna, Arun B Taly, Amit Soni, J Keshav Kumar, K Thennarasu
OBJECTIVES: To study the effects of cognitive retraining and inpatient rehabilitation to study the effects of cognitive retraining and inpatient rehabilitation in patients with acquired brain injury (ABI). DESIGN AND SETTING: This was a prospective follow-up study in a neurological rehabilitation department of quaternary research hospital. PATIENTS AND METHODS: Thirty patients with ABI, mean age 36.43 years (standard deviation [SD] 12.6, range 18-60), mean duration of illness 77...
July 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28691506/the-effect-of-music-therapy-on-cognitive-functions-in-patients-with-dementia-a-systematic-review-and-meta-analysis
#19
Laura Fusar-Poli, Łucja Bieleninik, Natascia Brondino, Xi-Jing Chen, Christian Gold
OBJECTIVES: The aim of the present study was to meta-analyze the effect of music therapy (MT) on cognitive functions in patients with dementia. METHOD: A systematic literature search was performed in Medline, PsycINFO, Embase, CINAHL and RILM up to 8 September 2016. We included all randomized controlled trials that compared MT with standard care, or other non-musical types of intervention, evaluating cognitive outcomes in patients with dementia. Outcomes included global cognition, complex attention, executive function, learning and memory, language, and perceptual-motor skills...
July 10, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28691167/exploring-the-link-between-visual-perception-visual-motor-integration-and-reading-in-normal-developing-and-impaired-children-using-dtvp-2
#20
Stéphanie Bellocchi, Mathilde Muneaux, Andréa Huau, Yohana Lévêque, Marianne Jover, Stéphanie Ducrot
Reading is known to be primarily a linguistic task. However, to successfully decode written words, children also need to develop good visual-perception skills. Furthermore, motor skills are implicated in letter recognition and reading acquisition. Three studies have been designed to determine the link between reading, visual perception, and visual-motor integration using the Developmental Test of Visual Perception version 2 (DTVP-2). Study 1 tests how visual perception and visual-motor integration in kindergarten predict reading outcomes in Grade 1, in typical developing children...
July 10, 2017: Dyslexia: the Journal of the British Dyslexia Association
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