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https://www.readbyqxmd.com/read/29785584/interferon-free-therapy-in-hepatitis-c-virus-hcv-monoinfected-and-hcv-hiv-coinfected-patients-effect-on-cognitive-function-fatigue-and-mental-health
#1
Felix Kleefeld, Sophie Heller, Patrick Ingiliz, Heiko Jessen, Anders Petersen, Ute Kopp, Antje Kraft, Katrin Hahn
The efficacy and safety of interferon-free therapies for hepatitis C virus (HCV) infection have been reported. Considering the accumulating evidence for a direct central nervous system infection by HCV, we aim to evaluate the effect of direct acting antivirals (DAA) therapy on cognitive function in HCV patients. We conducted a longitudinal analysis of the cognitive performance of 22 patients (8 HCV+, 14 HCV+/HIV+) who completed neuropsychological testing at baseline and at week 12 after DAA therapy. In 20 patients, we analyzed specific attention parameters derived from an experimental testing based on the Theory of Visual Attention (TVA)...
May 21, 2018: Journal of Neurovirology
https://www.readbyqxmd.com/read/29781345/sluggish-cognitive-tempo-predicts-academic-fluency-beyond-contributions-of-core-academic-skills-attention-and-motor-speed
#2
Lisa A Jacobson, E Mark Mahone
OBJECTIVE: Sluggish Cognitive Tempo (SCT) is a distinct behavioral phenotype characterized by such symptoms as being slow to complete tasks, appearing drowsy or sleepy, and lacking initiative. Subcomponents of SCT appear differentially associated with inattention symptoms and child outcomes. Much of the work in this area has examined associations between SCT symptoms and ratings of behavior; few studies have examined associations with child performance. METHOD: We examined associations between SCT and timed reading and math skills in 247 referred youth ( M age = 11...
May 1, 2018: Journal of Attention Disorders
https://www.readbyqxmd.com/read/29774475/neuropsychological-profiles-of-breast-cancer-and-brain-tumor-cohorts-in-northeast-ontario-canada
#3
Matias Mariani, Mark William Glister Collins
PURPOSE: As developments in cancer treatment have improved outcomes, research has increasingly focused on the role of cancer-related cognitive impairment (CRCI) in quality of life for cancer survivors. Impairment profiles have been heterogeneous across studies, necessitating the study of these effects across different cohorts. The purpose of this preliminary study is to compare the memory profiles of Northeast Ontario breast and CNS cancer patients, as there is no literature which exists for profiling CRCI within this largely rural region...
May 17, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29770998/maternal-depressive-symptoms-are-negatively-associated-with-child-growth-and-development-evidence-from-rural-india
#4
Phuong Hong Nguyen, Jed Friedman, Mohini Kak, Purnima Menon, Harold Alderman
Maternal depression has been suggested as a risk factor for both poor child growth and development in many low- and middle-income countries, but the validity of many studies is hindered by small sample sizes, varying cut-offs used in depression diagnostics, and incomplete control of confounding factors. This study examines the association between maternal depressive symptoms (MDSs) and child physical growth and cognitive development in Madhya Pradesh, India, where poverty, malnutrition, and poor mental health coexist...
May 17, 2018: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/29767802/sitting-together-and-reaching-to-play-start-play-protocol-for-a-multisite-randomized-controlled-efficacy-trial-on-intervention-for-infants-with-neuromotor-disorders
#5
Regina T Harbourne, Stacey C Dusing, Michele A Lobo, Sarah Westcott-McCoy, James Bovaird, Susan Sheridan, James C Galloway, Hui-Ju Chang, Lin-Ya Hsu, Natalie Koziol, Emily C Marcinowski, Iryna Babik
Background: There is limited research examining the efficacy of early physical therapy on infants with neuromotor dysfunction. In addition, most early motor interventions have not been directly linked to learning, despite the clear association between motor activity and cognition during infancy. Objective: The aim of this project is to evaluate the efficacy of Sitting Together And Reaching To Play (START-Play), an intervention designed to target sitting, reaching, and motor-based problem solving to advance global development in infants with motor delays or neuromotor dysfunction...
June 1, 2018: Physical Therapy
https://www.readbyqxmd.com/read/29767379/individual-cognitive-change-after-dbs-surgery-in-parkinson-s-disease-patients-using-reliable-change-index-methodology
#6
Thomas Foki, Daniela Hitzl, Walter Pirker, Klaus Novak, Gisela Pusswald, Johann Lehrner
Long-term therapy of Parkinson's disease (PD) with levodopa (L-DOPA) is associated with a high risk of developing motor fluctuations and dyskinesia. Deep brain stimulation (DBS) in PD patients of the subthalamic nucleus can improve these motor complications. Although the positive effect on motor symptoms has been proven, postoperative cognitive decline has been documented. To tackle the impact of PD-DBS on cognition, 18 DBS patients were compared to 25 best medically treated Parkinson's patients, 24 Mild Cognitive Impairment (MCI) patients and 12 healthy controls using the Neuropsychological Test Battery Vienna-long (NTBV-long) for cognitive outcome 12 months after first examination...
May 16, 2018: Neuropsychiatrie: Klinik, Diagnostik, Therapie und Rehabilitation
https://www.readbyqxmd.com/read/29757933/improving-physical-fitness-and-cognitive-functions-in-middle-school-students-study-protocol-for-the-chinese-childhood-health-activity-and-motor-performance-study-chinese-champs
#7
Zhixiong Zhou, Shanshan Dong, Jun Yin, Quan Fu, Hong Ren, Zenong Yin
Background : Sedentary lifestyles and their associated harmful consequences are public health concerns that impact more than half of the world's youth population in both developed and developing countries. Methods : The Chinese Childhood Health; Activity and Motor Performance Study (Chinese CHAMPS) was a cluster randomized controlled trial to modify school physical activity policies and the physical education (PE) curriculum; using teacher training and parent engagement to increase opportunities and support students' physical activity and healthy eating...
May 14, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29755513/motor-imagery-during-action-observation-of-locomotor-tasks-improves-rehabilitation-outcome-in-older-adults-after-total-hip-arthroplasty
#8
Uros Marusic, Sidney Grosprêtre, Armin Paravlic, Simon Kovač, Rado Pišot, Wolfgang Taube
This study aimed at determining whether the combination of action observation and motor imagery (AO + MI) of locomotor tasks could positively affect rehabilitation outcome after hip replacement surgery. Of initially 405 screened participants, 21 were randomly split into intervention group ( N = 10; mean age = 64 y; AO + MI of locomotor tasks: 30 min/day in the hospital, then 3×/week in their homes for two months) and control group ( N = 11, mean age = 63 y, active controls). The functional outcomes (Timed Up and Go, TUG; Four Step Square Test, FSST; and single- and dual-task gait and postural control) were measured before (PRE) and 2 months after surgery (POST)...
2018: Neural Plasticity
https://www.readbyqxmd.com/read/29754124/predictors-of-postoperative-rehabilitation-therapy-following-congenital-heart-surgery
#9
Ana Ubeda Tikkanen, Meena Nathan, Lynn A Sleeper, Marisa Flavin, Ana Lewis, Donna Nimec, John E Mayer, Pedro Del Nido
BACKGROUND: Patients with congenital heart disease are at risk of motor, cognitive, speech, and feeding difficulties after cardiac surgery. Rehabilitation therapy could improve functional outcomes in this population if applied in the acute postcardiac surgical in-hospital stay. However, information on the types of acute postcardiac surgery therapy needs in children is scarce. Our goal was to describe rehabilitation therapy following congenital heart surgery and pre/intraoperative factors associated with need for therapy...
May 12, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29753346/clinical-outcome-assessments-use-of-normative-data-in-a-pediatric-rare-disease
#10
Dawn Phillips, Beth Leiro
Pediatric rare diseases present unique challenges in clinical trial design and in selection of clinical outcome assessments (COAs) used to support claims in medical product labeling. COAs that discriminate level of function relative to a normative sample are particularly important in the pediatric rare disease setting because the literature is often void of natural history data. Pediatric rare disease clinical trials will often include a wide age distribution. Gross and fine motor skills, communication, cognition, and independence in activities of daily living vary by age, and it may be difficult to distinguish between treatment effect and change due to developmental maturation...
May 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29751966/outcomes-in-nursing-home-patients-with-traumatic-brain-injury
#11
Stephanie N Lueckel, Cyrus M Kosar, Joan M Teno, Sean F Monaghan, Daithi S Heffernan, William G Cioffi, Kali S Thomas
BACKGROUND: Traumatic brain injury is a leading cause of death and disability in the United States. In survivors, traumatic brain injury remains a leading contributor to long-term disability and results in many patients being admitted to skilled nursing facilities for postacute care. Despite this very large population of traumatic brain injury patients, very little is known about the long-term outcomes of traumatic brain injury survivors, including rates of discharge to home or risk of death in long-term nursing facilities...
May 9, 2018: Surgery
https://www.readbyqxmd.com/read/29751371/status-epilepticus-associated-with-acute-encephalitis-long-term-follow-up-of-functional-and-cognitive-outcomes-in-72-patients
#12
Weibi Chen, Yingying Su, Mengdi Jiang, Gang Liu, Fei Tian, Guoping Ren
BACKGROUND: Continued care in patients with encephalitis and prolonged status epilepticus (SE) is controversial. Limited data is available on the functional and cognitive outcomes. METHODS: In a prospective cohort study from 2007 to 2016, patients with acute encephalitis and SE were reviewed. Long-term outcomes including motor disability (modified Rankin Scale, mRS), daily living skills (activities of daily living, ADL), cognitive ability (modified Telephone Interview for Cognitive Status, TICS-M) and epilepsy sequelae, were evaluated in those survivors at 12-month follow-up...
May 11, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29745347/febrile-infection-related-epilepsy-syndrome-fires-an-overview-of-treatment-and-recent-patents
#13
Kam Lun E Lun Hon, Alexander K C Leung, Alcy R Torres
BACKGROUND: New-onset refractory status epilepticus (NORSE) refers to a clinical presentation in a patient without active epilepsy or other existing relevant neurological disorder, with new onset of refractory status epilepticus in the absence of a clear acute or active structural, metabolic, or toxic cause. Febrile infection-related epilepsy syndrome (FIRES) is a subset of NORSE that requires a febrile infection between 24 hours and 2 weeks prior to the onset of refractory status epilepticus, with or without fever at the onset of status epilepticus, and with no restriction to the age of the patient...
May 8, 2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/29740302/improved-volitional-recall-of-motor-imagery-related-brain-activation-patterns-using-real-time-functional-mri-based-neurofeedback
#14
Epifanio Bagarinao, Akihiro Yoshida, Mika Ueno, Kazunori Terabe, Shohei Kato, Haruo Isoda, Toshiharu Nakai
Motor imagery (MI), a covert cognitive process where an action is mentally simulated but not actually performed, could be used as an effective neurorehabilitation tool for motor function improvement or recovery. Recent approaches employing brain-computer/brain-machine interfaces to provide online feedback of the MI during rehabilitation training have promising rehabilitation outcomes. In this study, we examined whether participants could volitionally recall MI-related brain activation patterns when guided using neurofeedback (NF) during training...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29739443/cognition-and-bimanual-performance-in-children-with-unilateral-cerebral-palsy-protocol-for-a-multicentre-cross-sectional-study
#15
Brian Hoare, Michael Ditchfield, Megan Thorley, Margaret Wallen, Jenny Bracken, Adrienne Harvey, Catherine Elliott, Iona Novak, Ali Crichton
BACKGROUND: Motor outcomes of children with unilateral cerebral palsy are clearly documented and well understood, yet few studies describe the cognitive functioning in this population, and the associations between the two is poorly understood. Using two hands together in daily life involves complex motor and cognitive processes. Impairment in either domain may contribute to difficulties with bimanual performance. Research is yet to derive whether, and how, cognition affects a child's ability to use their two hands to perform bimanual tasks...
May 8, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29738911/a-comprehensive-evaluation-of-increasing-temporal-resolution-with-multiband-accelerated-protocols-and-effects-on-statistical-outcome-measures-in-fmri
#16
Lysia Demetriou, Oliwia S Kowalczyk, Gabriella Tyson, Thomas Bello, Rexford D Newbould, Matthew B Wall
Accelerated functional Magnetic Resonance Imaging (fMRI) with 'multiband' protocols is now relatively widespread. These protocols can be used to dramatically reduce the repetition time (TR) and produce a time-series sampled at a higher temporal resolution, which may produce benefits in the statistical methods typically used to analyse fMRI data. We tested the effects of higher temporal resolutions for fMRI on statistical outcome measures in a comprehensive manner on two different MRI scanner platforms. Spatial resolution was maintained at a constant of 3 mm isotropic voxels, and an in-plane acceleration factor of 2 was used for all experiments...
May 5, 2018: NeuroImage
https://www.readbyqxmd.com/read/29738744/a-systematic-review-with-meta-analysis-of-mindful-exercises-on-rehabilitative-outcomes-among-post-stroke-patients
#17
REVIEW
Liye Zou, Jeffer Eidi Sasaki, Nan Zeng, Chaoyi Wang, Li Sun
OBJECTIVE: To critically evaluate the rehabilitative effects of mindful exercises for post-stroke patients. DATA SOURCES: Six databases (PubMed, Physiotherapy Evidence Database, Cochrane Library, Web of Science, Wanfang, and CNKI) and reference lists of relevant articles were searched. STUDY SELECTION: Randomized controlled trials (RCTs) on the effects of mindful exercises on rehabilitative outcomes such as sensorimotor function, gait speed, leg strength, aerobic endurance, cognitive function, and overall motor function)...
May 5, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29735513/a-unifying-theory-for-cognitive-abnormalities-in-functional-neurological-disorders-fibromyalgia-and-chronic-fatigue-syndrome-systematic-review
#18
REVIEW
Tiago Teodoro, Mark J Edwards, Jeremy D Isaacs
BACKGROUND: Functional cognitive disorder (FCD) describes cognitive dysfunction in the absence of an organic cause. It is increasingly prevalent in healthcare settings yet its key neuropsychological features have not been reported in large patient cohorts. We hypothesised that cognitive profiles in fibromyalgia (FM), chronic fatigue syndrome (CFS) and functional neurological disorders (FNDs) would provide a template for characterising FCD. METHODS: We conducted a systematic review of studies with cognition-related outcomes in FM, CFS and FND...
May 7, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29734144/long-term-neurodevelopmental-and-respiratory-outcome-after-intrauterine-therapy-for-fetal-thoracic-abnormalities
#19
Ruben S G M Witlox, Enrico Lopriore, Monique Rijken, Frans J C M Klumper, Dick Oepkes, Jeanine M M van Klink
INTRODUCTION: The aim of this study is to evaluate long-term neurodevelopmental and respiratory outcome after fetal therapy for fetal pleural effusion, congenital cystic adenomatoid malformation, and bronchopulmonary sequestration. METHODS: Children ≥18 months of age underwent an assessment of neurologic, motor, and cognitive development. Medical records were reviewed to determine respiratory outcome. Behavioral outcome was assessed using the Child Behavioral Checklist...
May 7, 2018: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/29730660/perinatal-outcome-and-long-term-neurodevelopment-after-intracranial-haemorrhage-due-to-fetal-and-neonatal-alloimmune-thrombocytopenia
#20
Dian Winkelhorst, Marije M Kamphuis, Sylke J Steggerda, Monique Rijken, Dick Oepkes, Enrico Lopriore, Jeanine M M van Klink
OBJECTIVES: To evaluate the perinatal and long-term neurodevelopmental outcome in a cohort of children with intracranial haemorrhage (ICH) due to fetal and neonatal alloimmune thrombocytopenia (FNAIT) and to clearly outline the burden of this disease. SUBJECTS AND METHODS: We performed an observational cohort study and included all consecutive cases of ICH caused by FNAIT from 1993 to 2015 at Leiden University Medical Centre. Neurological, motor, and cognitive development were assessed at a minimum age of 1 year...
May 4, 2018: Fetal Diagnosis and Therapy
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