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https://www.readbyqxmd.com/read/29196052/ferulic-acid-loaded-nanostructured-lipid-carriers-a-promising-nanoformulation-against-the-ischemic-neural-injuries
#1
Parichehr Hassanzadeh, Elham Arbabi, Fatemeh Atyabi, Rassoul Dinarvand
AIMS: Treatment of the ischemic stroke has remained a major healthcare challenge. The phenolic compound, ferulic acid (FA), has shown promising antioxidant and neuroprotective effects, however, low bioavailability may negatively affect its efficiency. This, prompted us to incorporate FA into the nanostructured lipid carriers (FA-NLCs) and evaluate its therapeutic potential in in vitro and in vivo models of ischemic stroke. MAIN METHODS: FA-NLCs were prepared by high-pressure homogenization followed by physicochemical characterization, evaluation of the bioactivity of FA-NLCs in oxygen-glucose deprivation (OGD) and global cerebral ischemia/reperfusion (I/R) injury and implication of phosphatidylinositol 3-kinase (PI3K) pathway in this regard...
November 28, 2017: Life Sciences
https://www.readbyqxmd.com/read/29190147/when-normal-scores-don-t-equate-to-independence-recalibrating-ratings-of-neurobehavioural-disability-from-the-st-andrew-s-swansea-neurobehavioural-outcome-scale-to-reflect-context-dependent-support
#2
Nick Alderman, Claire Williams, Rodger Ll Wood
PRIMARY OBJECTIVE: Context is critical to the interpretation of measurement instruments that capture acquired brain injury (ABI) outcomes. Ratings reflect behaviours and abilities observed in a particular setting; it cannot be assumed that results are generalizable beyond these. This study explored the utility of a method to convey the impact of context-dependent support given on ratings of neurobehavioural disability (NBD) using the St Andrews-Swansea Neurobehavioural Outcome Scale (SASNOS)...
November 30, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29173065/neurobehavioural-effects-of-lactobacillus-rhamnosus-gg-alone-and-in-combination-with-prebiotics-polydextrose-and-galactooligosaccharide-in-male-rats-exposed-to-early-life-stress
#3
Karen-Anne McVey Neufeld, Siobhain M O'Mahony, Alan E Hoban, Rosaline V Waworuntu, Brian M Berg, Timothy G Dinan, John F Cryan
Early life is a period of significant brain development when the brain is at its most plastic and vulnerable. Stressful episodes during this window of development have long-lasting effects on the central nervous system. Rodent maternal separation (MS) is a reliable model of early-life stress and induces alterations in both physiology and behaviour. Intriguingly, the gut microbiota of MS offspring differ from that of non-separated offspring, suggesting a mechanistic role for the microbiota-gut-brain axis. Hence, we tested whether dietary factors known to affect the gut microbiota alter the neurobehavioural effects of MS...
November 27, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29124633/an-update-of-the-worldwide-integrated-assessment-wia-on-systemic-insecticides-part-2-impacts-on-organisms-and-ecosystems
#4
Lennard Pisa, Dave Goulson, En-Cheng Yang, David Gibbons, Francisco Sánchez-Bayo, Edward Mitchell, Alexandre Aebi, Jeroen van der Sluijs, Chris J K MacQuarrie, Chiara Giorio, Elizabeth Yim Long, Melanie McField, Maarten Bijleveld van Lexmond, Jean-Marc Bonmatin
New information on the lethal and sublethal effects of neonicotinoids and fipronil on organisms is presented in this review, complementing the previous Worldwide Integrated Assessment (WIA) in 2015. The high toxicity of these systemic insecticides to invertebrates has been confirmed and expanded to include more species and compounds. Most of the recent research has focused on bees and the sublethal and ecological impacts these insecticides have on pollinators. Toxic effects on other invertebrate taxa also covered predatory and parasitoid natural enemies and aquatic arthropods...
November 9, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29108742/gene-expression-analysis-reveals-chronic-low-level-exposure-to-the-pesticide-diazinon-affects-psychological-disorders-gene-sets-in-the-adult-rat
#5
Claire Y Savy, Ann E Fitchett, Peter G Blain, Christopher M Morris, Sarah J Judge
Chronic low level exposure to organophosphate (OPs) pesticides in adulthood has been linked to adverse neurobehavioural deficits and psychological disorder symptoms, although this remains a contentious issue. The OP-induced biological changes that could underlie these effects are unclear. We assessed gene expression changes following chronic low level exposure to diazinon, a pesticide with a high dietary exposure risk. Adult male rats were orally exposed to diazinon (0, 1, 2mg/kg, 5days a week for 12 weeks)...
November 3, 2017: Toxicology
https://www.readbyqxmd.com/read/29053771/the-cerebellum-in-alzheimer-s-disease-evaluating-its-role-in-cognitive-decline
#6
Heidi I L Jacobs, David A Hopkins, Helen C Mayrhofer, Emiliano Bruner, Fred W van Leeuwen, Wijnand Raaijmakers, Jeremy D Schmahmann
The cerebellum has long been regarded as essential only for the coordination of voluntary motor activity and motor learning. Anatomical, clinical and neuroimaging studies have led to a paradigm shift in the understanding of the cerebellar role in nervous system function, demonstrating that the cerebellum appears integral also to the modulation of cognition and emotion. The search to understand the cerebellar contribution to cognitive processing has increased interest in exploring the role of the cerebellum in neurodegenerative and neuropsychiatric disorders...
July 28, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29027013/a-systematic-review-of-maternal-antidepressant-use-in-pregnancy-and-short-and-long-term-offspring-s-outcomes
#7
REVIEW
Stephanie L Prady, Inna Hanlon, Lorna K Fraser, Antonina Mikocka-Walus
The relative safety of antidepressants during pregnancy has received substantial attention, but most syntheses fail to account for mental illness effects. We aimed to evaluate the literature comparing low birth weight (LBW) and neurodevelopmental and neurobehavioural outcomes for children whose mothers took antidepressants in pregnancy compared to those whose mothers had common mental disorders, or symptoms, but who did not take antidepressants during pregnancy. A systematic review was conducted searching PubMed, MEDLINE, PsycINFO and Embase in January 2015...
October 12, 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/28993495/sleep-research-goes-wild-new-methods-and-approaches-to-investigate-the-ecology-evolution-and-functions-of-sleep
#8
REVIEW
Niels C Rattenborg, Horacio O de la Iglesia, Bart Kempenaers, John A Lesku, Peter Meerlo, Madeleine F Scriba
Despite being a prominent aspect of animal life, sleep and its functions remain poorly understood. As with any biological process, the functions of sleep can only be fully understood when examined in the ecological context in which they evolved. Owing to technological constraints, until recently, sleep has primarily been examined in the artificial laboratory environment. However, new tools are enabling researchers to study sleep behaviour and neurophysiology in the wild. Here, we summarize the various methods that have enabled sleep researchers to go wild, their strengths and weaknesses, and the discoveries resulting from these first steps outside the laboratory...
November 19, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28969320/isoflurane-exposure-for-three-hours-triggers-apoptotic-cell-death-in-neonatal-macaque-brain
#9
K K Noguchi, S A Johnson, G A Dissen, L D Martin, F M Manzella, K J Schenning, J W Olney, A M Brambrink
Background: Retrospective clinical studies suggest there is a risk for neurodevelopmental impairment following early childhood exposure to anaesthesia. In the developing animal brain, including those of non-human primates (NHPs), anaesthetics induce apoptotic cell death. We previously reported that a 5 h isoflurane (ISO) exposure in infant NHPs increases apoptosis 13-fold compared with control animals. However, the majority of paediatric surgeries requiring anaesthesia are of shorter durations...
September 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28969107/intracarotid-sodium-nitroprusside-on-fifth-post-ischemic-stroke-day-in-middle-cerebral-artery-occlusion-rat-model
#10
Vinod Kumar Tewari, Vivek Bhosale, Rakesh Shukla, Hari Kishan Das Gupta, Sheeba
INTRODUCTION: Ischemic stroke at later stages (>4.5 hour) have very few treatment options left. In those cases Nitric Oxide (NO) may provide promising results. NO is active in signaling pathways. Sodium Nitroprusside (SNP), a NO donor was tested earlier in rat Middle Cerebral Artery Occlusion (MCAO) model in early stages (5-60 minutes) and found useful but in delayed stroke cases (60-120 minutes) found useless. This was due to local inducible Nitric Oxide Synthase Enzyme (iNOS) and superoxide (causes destructive effect) formation which was skipped...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28951450/top-down-modulation-of-auditory-motor-integration-during-speech-production-the-role-of-working-memory
#11
Zhiqiang Guo, Xiuqin Wu, Weifeng Li, Jeffery A Jones, Nan Yan, Stanley Sheft, Peng Liu, Hanjun Liu
Although working memory (WM) is considered as an emergent property of the speech perception and production systems, the role of WM in sensorimotor integration during speech processing is largely unknown. We conducted two event-related potential experiments with female and male young adults to investigate the contribution of WM to the neurobehavioural processing of altered auditory feedback during vocal production. A delayed match-to-sample task that required participants to indicate whether the pitch feedback perturbations they heard during vocalizations in test and sample sequences matched, elicited significantly larger vocal compensations, larger N1 responses in the left middle and superior temporal gyrus, and smaller P2 responses in the left middle and superior temporal gyrus, inferior parietal lobule, somatosensory cortex, right inferior frontal gyrus, and insula compared with a control task that did not require memory retention of the sequence of pitch perturbations...
October 25, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28934247/the-extent-of-intrauterine-growth-restriction-determines-the-severity-of-cerebral-injury-and-neurobehavioural-deficits-in-rodents
#12
Crystal A Ruff, Stuart D Faulkner, Prakasham Rumajogee, Stephanie Beldick, Warren Foltz, Jennifer Corrigan, Alfred Basilious, Shangjun Jiang, Shanojan Thiyagalingam, Jerome Y Yager, Michael G Fehlings
BACKGROUND: Cerebral Palsy (CP) is the most common physical pediatric neurodevelopmental disorder and spastic diplegic injury is its most frequent subtype. CP results in substantial neuromotor and cognitive impairments that have significant socioeconomic impact. Despite this, its underlying pathophysiological mechanisms and etiology remain incompletely understood. Furthermore, there is a need for clinically relevant injury models, which a) reflect the heterogeneity of the condition and b) can be used to evaluate new translational therapies...
2017: PloS One
https://www.readbyqxmd.com/read/28854169/a-somatic-mutation-in-erythro-myeloid-progenitors-causes-neurodegenerative-disease
#13
Elvira Mass, Christian E Jacome-Galarza, Thomas Blank, Tomi Lazarov, Benjamin H Durham, Neval Ozkaya, Alessandro Pastore, Marius Schwabenland, Young Rock Chung, Marc K Rosenblum, Marco Prinz, Omar Abdel-Wahab, Frederic Geissmann
The pathophysiology of neurodegenerative diseases is poorly understood and there are few therapeutic options. Neurodegenerative diseases are characterized by progressive neuronal dysfunction and loss, and chronic glial activation. Whether microglial activation, which is generally viewed as a secondary process, is harmful or protective in neurodegeneration remains unclear. Late-onset neurodegenerative disease observed in patients with histiocytoses, which are clonal myeloid diseases associated with somatic mutations in the RAS-MEK-ERK pathway such as BRAF(V600E), suggests a possible role of somatic mutations in myeloid cells in neurodegeneration...
September 21, 2017: Nature
https://www.readbyqxmd.com/read/28833840/genetic-disorders-and-neurobehavioural-phenotypes
#14
EDITORIAL
S Huijbregts, A Jansen
No abstract text is available yet for this article.
September 2017: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/28802139/analysis-of-neurobehavioural-data-by-chemometric-methods-in-ecotoxicological-studies
#15
Cristian Gómez-Canela, Eva Prats, Romà Tauler, Demetrio Raldúa
Incorporation of chemometric tools in behavioural data management workflows allows for the early identification of most relevant endpoints complementarily to statistical confirmatory approaches. In this work, the effects of two model neurotoxicants, chlorpyrifos (CPF) and nicotine, exposures on behavioural profiles of adult zebrafish at three different times (2, 6 and 24h) were evaluated using open field test (OFT) paradigm experiments. Two chemometric methods like Principal Component Analysis (PCA) and Analysis of Variance-Simultaneous Component Analysis (ASCA) have been used to interpret the changes observed in the obtained behavioural data...
August 9, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28796376/neuropsychiatric-adverse-events-of-antiepileptic-drugs-in-brain-tumour-related-epilepsy-an-italian-multicentre-prospective-observational-study
#16
C Bedetti, M Romoli, M Maschio, C Di Bonaventura, E Nardi Cesarini, P Eusebi, S Siliquini, S Dispenza, P Calabresi, C Costa
BACKGROUND AND PURPOSE: We assessed the prevalence and magnitude of neuropsychiatric adverse events (NPAEs) associated with antiepileptic drugs (AEDs) among patients with brain tumour-related epilepsy (BTRE). METHODS: This observational, prospective, multicentre study enrolled 259 patients with BTRE after neurosurgery. All patients received AED monotherapy. Efficacy was assessed through clinical diaries, whereas NPAEs were collected using the Neuropsychiatric Inventory Test-12 questionnaire at baseline and after 5 months...
August 10, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28782143/dynamics-of-cerebral-responses-to-sustained-attention-performance-during-one-night-of-sleep-deprivation
#17
Yuanqiang Zhu, Yibin Xi, Ningbo Fei, Yuchen Liu, Xinxin Zhang, Lin Liu, Ziliang Xu, Jinbo Sun, Xuejuan Yang, Hong Yin, Jie Tian, Wei Qin
Total sleep deprivation (TSD) is increasingly common in modern society bringing various neurobehavioural effects. Dynamic changes of behaviour performances during TSD have been reported extensively, while the cerebral activation underlying such changes have not been elucidated clearly. This study aimed to investigate dynamic changes in cerebral responses to the fastest and slowest psychomotor vigilance task (PVT) trials during TSD. Thirty-six healthy subjects with intermediate chronotype performed the PVT while undergoing functional magnetic resonance imaging every 2 h from 22:00 hours on the first day to 06:00 hours on the second day (i...
August 6, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28762872/the-role-of-the-smart-and-whim-in-behavioural-assessment-of-disorders-of-consciousness-clinical-utility-and-scope-for-a-symbiotic-relationship
#18
Ann-Marie Morrissey, Helen Gill-Thwaites, Barbara Wilson, Rachel Leonard, Lindsay McLellan, Amy Pundole, Agnes Shiel
As the prevalence and incidence of disorders of consciousness (DoC) increase, researchers and clinicians are tasked with developing best practice assessment techniques. Neurobehavioural assessment remains the most clinically available method of measuring consciousness. Neuroimaging and other physiological measurements are demonstrating promise in supporting this assessment but many of these techniques require further research and are not widely available in sub-acute and long-term care settings. No study to date has explored in-depth complementary use of multiple neurobehavioural assessments in aiding beside assessment of consciousness...
August 1, 2017: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/28743991/altered-visual-cortical-processing-in-a-mouse-model-of-mecp2-duplication-syndrome
#19
Dinghong Zhang, Bin Yu, Jing Liu, Weiqian Jiang, Taorong Xie, Ran Zhang, Dali Tong, Zilong Qiu, Haishan Yao
As an epigenetic modulator of gene expression, Methyl-CpG binding protein 2 (MeCP2) is essential for normal neurological function. Dysfunction of MeCP2 is associated with a variety of neurological disorders. MECP2 gene duplication in human causes neuropsychiatric symptoms such as mental retardation and autism. MeCP2 overexpression in mice results in neurobehavioural disorders, dendritic abnormalities, and synaptic defects. However, how gain of MeCP2 function influences cortical processing of sensory information remains unclear...
July 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28710219/comparison-of-propofol-and-dexmedetomidine-infused-overnight-to-treat-hyperactive-and-mixed-icu-delirium-a-protocol-for-the-basel-prodex-clinical-trial
#20
Alexa Hollinger, Katrin Ledergerber, Stefanie von Felten, Raoul Sutter, Stephan Rüegg, Lukas Gantner, Sibylle Zimmermann, Andrea Blum, Luzius A Steiner, Stephan Marsch, Martin Siegemund
BACKGROUND/OBJECTIVES: Delirium is a neurobehavioural disturbance that frequently develops particularly in the intensive care unit (ICU) population. It was first described more than half a century ago, where it was already discovered as a state that might come along with serious complications such as prolonged ICU and hospital stay, reduced quality of life and increased mortality. However, in most cases, there is still lack of proof for causal relationship. Its presence frequently remains unrecognised due to suggested predominance of the hypoactive form...
July 13, 2017: BMJ Open
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