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https://www.readbyqxmd.com/read/28025035/resveratrol-suppresses-neuroinflammation-in-the-experimental-paradigm-of-autism-spectrum-disorders
#1
Ranjana Bhandari, Anurag Kuhad
BACKGROUND: Neuronal dysfunction caused by neuroinflammation triggered by the stimulation of matrix metalloproteinases and the subsequent release of pro-inflammatory cytokines, as a result of oxidative stress and mitochondrial dysfunction, is one of the probable mechanisms involved in the pathogenesis of autism spectrum disorders (ASD). The aim of the present study was to explore the ameliorative potential of resveratrol on neuroinflammation in the experimental paradigm of neuroinflammatory model of ASD in rats...
December 23, 2016: Neurochemistry International
https://www.readbyqxmd.com/read/27974137/health-effects-associated-with-measured-levels-of-contaminants-in-the-arctic
#2
Pál Weihe, Fróði Debes, Jónrit Halling, Maria Skaalum Petersen, Gina Muckle, Jon Øyvind Odland, Alexey Dudarev, Pierre Ayotte, Éric Dewailly, Philippe Grandjean, Eva Bonefeld-Jørgensen
The Human Health Assessment Group has over the past decade recommended that effect studies be conducted in the circumpolar area. Such studies examine the association between contaminant exposure in the Arctic populations and health effects. Because foetuses and young children are the most vulnerable, effect studies are often prospective child cohort studies. The emphasis in this article is on a description of the effects associated with contaminant exposure in the Arctic. The main topics addressed are neurobehavioural, immunological, reproductive, cardiovascular, endocrine and carcinogenic effect...
2016: International Journal of Circumpolar Health
https://www.readbyqxmd.com/read/27922243/late-diagnosed-phenylketonuria-in-an-eight-year-old-boy-with-dyslexia-and-attention-deficit-hyperactivity-disorder
#3
Yılmaz Yıldız, Ali Dursun, Ayşegül Tokatlı, Turgay Coşkun, Hatice Serap Sivri
Phenylketonuria, previously a common cause of severe intellectual disability, is a metabolic disorder now promptly diagnosed and effectively treated thanks to newborn screening programs. Here, we report a male patient presenting with dyslexia and attention-deficit hyperactivity disorder, who was diagnosed with mild phenylketonuria at eight years of age. Earlier recognition and treatment before the establishment of irreversible brain damage would have resulted in better neurobehavioural outcomes. Classical phenylketonuria and milder phenotypes of phenylalanine hydroxylase deficiency need to be considered in the differential diagnosis of all cognitive and behavioural problems of unknown cause...
2016: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/27920084/caffeine-consumption-during-pregnancy-and-adhd-at-the-age-of-11%C3%A2-years-a-birth-cohort-study
#4
Bianca Del-Ponte, Iná S Santos, Luciana Tovo-Rodrigues, Luciana Anselmi, Tiago N Munhoz, Alicia Matijasevich
OBJECTIVE: Studies evaluating caffeine intake during pregnancy and long-term outcomes, such as the child's neurobehaviour, are still scarce and their results are inconsistent. The objective of the present study was to evaluate the association between maternal consumption of caffeine during pregnancy and attention deficit hyperactivity disorder (ADHD) at the age of 11 years. METHODOLOGY: All children born in the city of Pelotas, Brazil, during the year 2004, were selected for a cohort study...
December 5, 2016: BMJ Open
https://www.readbyqxmd.com/read/27908630/non-linear-dose-response-of-aluminium-hydroxide-adjuvant-particles-selective-low-dose-neurotoxicity
#5
Guillemette Crépeaux, Housam Eidi, Marie-Odile David, Yasmine Baba-Amer, Eleni Tzavara, Bruno Giros, François-Jérôme Authier, Christopher Exley, Christopher A Shaw, Josette Cadusseau, Romain K Gherardi
Aluminium (Al) oxyhydroxide (Alhydrogel(®)), the main adjuvant licensed for human and animal vaccines, consists of primary nanoparticles that spontaneously agglomerate. Concerns about its safety emerged following recognition of its unexpectedly long-lasting biopersistence within immune cells in some individuals, and reports of chronic fatigue syndrome, cognitive dysfunction, myalgia, dysautonomia and autoimmune/inflammatory features temporally linked to multiple Al-containing vaccine administrations. Mouse experiments have documented its capture and slow transportation by monocyte-lineage cells from the injected muscle to lymphoid organs and eventually the brain...
January 15, 2017: Toxicology
https://www.readbyqxmd.com/read/27891609/role-of-trpm7-in-cerebral-ischaemia-and-hypoxia
#6
Hong-Shuo Sun
Transient receptor potential melastatin 7 (TRPM7) channel, a calcium-permeable non-selective divalent cation channel, is broadly expressed in various cells and tissues, including the brain. TRPM7 is thought to be coupled to the metabolic state and regulate calcium homeostasis in the cell. TRPM7 takes part in a wide range of cell biology processes that affect cell growth and proliferation, as well as in embryonic development and skeleton formation. TRPM7 plays a significant role in ischaemic and hypoxic brain injury and neuronal cell death...
November 27, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27889232/l-methionine-and-silymarin-a-comparison-of-prophylactic-protective-capabilities-in-acetaminophen-induced-injuries-of-the-liver-kidney-and-cerebral-cortex
#7
Olakunle J Onaolapo, Moses A Adekola, Taiwo O Azeez, Karimat Salami, Adejoke Y Onaolapo
We compared the relative protective abilities of silymarin and l-methionine pre-treatment in acetaminophen overdose injuries of the liver, kidney and cerebral cortex by assessing behaviours, antioxidant status, tissue histological changes and biochemical parameters of hepatic/renal function. Rats were divided into six groups of ten each; animals in five of these groups were pre-treated with oral distilled water, silymarin (25mg/kg) or l-methionine (2.5, 5 and 10mg/kg body weight) for 14days; and then administered intraperitoneal (i...
January 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27878417/neurobehavioural-evaluation-of-resveratrol-in-murine-models-of-anxiety-and-schizophrenia
#8
Mohammed Garba Magaji, Loretta Oghenekome Iniaghe, Mutiat Abolarin, Opeyemi Isa Abdullahi, Rabiu Abdusalam Magaji
Resveratrol, a caloric restriction mimetic, is a naturally occurring polyphenolic compound with antioxidant and anti-inflammatory properties. Oxidative stress has been implicated in the etiology of a number of neuropsychiatric disorders including generalized anxiety and schizophrenia. This study investigated the anxiolytic and antipsychotic potentials of resveratrol in murine models of anxiety and schizophrenia. Mice were pretreated with resveratrol (200 and 400 mg/kg) in 1% carboxymethyl cellulose for 14 days and subjected to behavioural tests on the 15th day...
November 22, 2016: Metabolic Brain Disease
https://www.readbyqxmd.com/read/27857130/early-life-exposure-to-edcs-role-in-childhood-obesity-and-neurodevelopment
#9
REVIEW
Joseph M Braun
Endocrine-disrupting chemicals (EDCs) might increase the risk of childhood diseases by disrupting hormone-mediated processes that are critical for growth and development during gestation, infancy and childhood. The fetus, infant and child might have enhanced sensitivity to environmental stressors such as EDCs due to their rapid development and increased exposure to some EDCs as a consequence of development-specific behaviour, anatomy and physiology. In this Review, I discuss epidemiological studies examining the relationship between early-life exposure to bisphenol A (BPA), phthalates, triclosan and perfluoroalkyl substances (PFAS) with childhood neurobehavioural disorders and obesity...
November 18, 2016: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/27834333/effect-of-lamotrigine-levetiracetam-topiramate-on-neurobehavioural-parameters-oxidative-stress-in-comparison-with-valproate-in-rats
#10
Sudhir Chandra Sarangi, Ashish Kumar Kakkar, Ritesh Kumar, Yogendra Kumar Gupta
BACKGROUND & OBJECTIVES: Though newer antiepileptic drugs are considered safer than conventional antiepileptics, the effects of lamotrigine, levetiracetam and topiramate on neurobehavioural functions are yet to be established. This study evaluated neurobehavioural parameters and oxidative stress markers in brain tissue of rats treated with lamotrigine, levetiracetam and topiramate compared to sodium valproate . METHODS: Five groups of male Wistar rats were treated respectively with normal saline (control), sodium valproate (370 mg/kg), lamotrigine (50 mg/kg), levetiracetam (310 mg/kg) and topiramate (100 mg/kg) for 45 days...
July 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27812507/gene-expression-in-the-mouse-brain-following-early-pregnancy-exposure-to-ethanol
#11
Christine R Zhang, Suyinn Chong
Exposure to alcohol during early embryonic or fetal development has been linked with a variety of adverse outcomes, the most common of which are structural and functional abnormalities of the central nervous system [1]. Behavioural and cognitive deficits reported in individuals exposed to alcohol in utero include intellectual impairment, learning and memory difficulties, diminished executive functioning, attention problems, poor motor function and hyperactivity [2]. The economic and social costs of these outcomes are substantial and profound [3], [4]...
December 2016: Genomics Data
https://www.readbyqxmd.com/read/27810782/effect-of-l-pglu-1-benzyl-l-his-l-pro-nh2-against-in-vitro-and-in-vivo-models-of-cerebral-ischemia-and-associated-neurological-disorders
#12
Satyendra K Rajput, Arun K Sharma, Chhuttan L Meena, Aditya B Pant, Rahul Jain, Shyam S Sharma
Central nervous system plays a vital role in regulation of most of biological functions which are abnormally affected in various disorders including cerebral ischemia, Alzheimer's and Parkinson's (AD and PD) worldwide. Cerebral stroke is an extremely fatal and one of the least comprehensible neurological disorders due to limited availability of prospective clinical approaches and therapeutics. Since, some endogenous peptides like thyrotropin-releasing hormone have shown substantial neuroprotective potential, hence present study evaluates the newer thyrotropin-releasing hormone (TRH) analogue L-pGlu-(1-benzyl)-l-His-l-Pro-NH2 for its neuroprotective effects against oxygen glucose deprivation (OGD), glutamate and H2O2 induced injury in pheochromocytoma cell lines (PC-12 cells) and in-vivo ischemic injury in mice...
December 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27778335/neurobehaviour-at-term-in-infants-born-moderately-and-late-preterm-is-associated-with-cognition-at-2-years
#13
Mijna Hadders-Algra
No abstract text is available yet for this article.
February 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/27778080/richtwerte-f%C3%A3-r-toluol-und-gesundheitliche-bewertung-von-c7-c8-alkylbenzolen-in-der-innenraumluft-mitteilung-des-ausschusses-f%C3%A3-r-innenraumrichtwerte
#14
(no author information available yet)
The German Committee on Indoor Guide Values issues indoor air guide values to protect public health. For health evaluation of inhaled toluene a number of valid studies in humans is available. Toluene is a neurotoxic substance and the guide values are based on deficits in neurobehavioural tests observed at workers with chronic exposure of 337 mg toluene/m³. For the derivation of guide values the assumed continuous exposure is considered by a factor of 4.2, the interindividual variability by a factor of 10 and the elevated respiratory rate in children as compared to adults by a factor of 2...
November 2016: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/27775148/neurobehaviour-at-term-equivalent-age-and-neurodevelopmental-outcomes-at-2-years-in-infants-born-moderate-to-late-preterm
#15
Alicia J Spittle, Jennifer M Walsh, Cody Potter, Emma Mcinnes, Joy E Olsen, Katherine J Lee, Peter J Anderson, Lex W Doyle, Jeanie L Y Cheong
AIM: To examine the association between newborn neurobehavioural assessments and neurodevelopmental outcomes at 2 years in infants born moderate-to-late preterm (MLPT). METHOD: Two-hundred and one infants born MLPT (born 32-36(+6) wks' gestation) were assessed with the Hammersmith Neonatal Neurological Examination (HNNE) and NICU Network Neurobehavioral Scale (NNNS), with suboptimal performance defined as scores lower than the 10th centile. Development was assessed at 2 years corrected age with the Bayley Scales of Infant and Toddler Development 3rd Edition, with delay defined as scores less than 1 standard deviation (SD) below the mean...
February 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/27744650/household-interventions-for-preventing-domestic-lead-exposure-in-children
#16
REVIEW
Barbara Nussbaumer-Streit, Berlinda Yeoh, Ursula Griebler, Lisa M Pfadenhauer, Laura K Busert, Stefan K Lhachimi, Szimonetta Lohner, Gerald Gartlehner
BACKGROUND: Lead poisoning is associated with physical, cognitive and neurobehavioural impairment in children, and trials have tested many household interventions to prevent lead exposure. This is an update of the original review, first published in 2008. OBJECTIVES: To assess the effects of household interventions for preventing or reducing lead exposure in children, as measured by improvements in cognitive and neurobehavioural development, reductions in blood lead levels and reductions in household dust lead levels...
October 16, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27737812/solvent-neurotoxicity-in-vehicle-collision-repair-workers-in-new-zealand
#17
Samuel Keer, Bill Glass, Bradley Prezant, David McLean, Neil Pearce, Elizabeth Harding, Diana Echeverria, James McGlothlin, Duncan R Babbage, Jeroen Douwes
OBJECTIVES: To assess whether solvent use and workplace practices in the vehicle collision repair industry are associated with symptoms of neurotoxicity in spray painters and panel beaters (auto body repair workers). METHODS: Neurobehavioural symptoms were assessed using a cross-sectional study design in 370 vehicle collision repair and 211 reference workers using the EUROQUEST questionnaire. Full-shift airborne solvent levels were measured in a subset (n=92) of collision repair workers...
October 11, 2016: Neurotoxicology
https://www.readbyqxmd.com/read/27725106/latent-toxoplasmosis-is-associated-with-neurocognitive-impairment-in-young-adults-with-and-without-chronic-hiv-infection
#18
L Ene, T D Marcotte, A Umlauf, C Grancea, A Temereanca, A Bharti, C L Achim, S Letendre, S M Ruta
We evaluated the impact of latent toxoplasmosis (LT) on neurocognitive (NC) and neurobehavioural functioning in young adults with and without chronic HIV infection, using a standardised NC test battery, self-reported Beck Depression Inventory, Frontal System Behavior Scale, MINI-International Neuropsychiatric Interview and risk-assessment battery. 194 young adults (median age 24years, 48.2% males) with chronic HIV infection (HIV+) since childhood and 51 HIV seronegative (HIV-) participants were included. HIV+ individuals had good current immunological status (median CD4: 479 cells/μl) despite a low CD4 nadir (median: 93 cells/μl)...
October 15, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27720132/sex-specific-influence-on-the-relationship-between-maternal-exposures-to-persistent-chemicals-and-birth-outcomes
#19
Anna Carita Callan, Andrea Lee Hinwood, Jane Heyworth, Duong Trong Phi, Jon Ø Odland
Prenatal exposure to persistent pollutants has been associated with adverse birth outcomes, although few studies have investigated the influence of the sex of the infant. Sex specific differences have been associated with neurobehavioural impacts from environmental exposures with limited and contrary findings in relation to persistent pollutants. This study investigated the relationships between maternal exposure to a range of metals, polychlorinated biphenyls and pesticides measured in biological samples and birth outcomes with a specific focus on the sex of the infant...
September 28, 2016: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/27679680/exercising-control-over-bipolar-disorder
#20
Gin S Malhi, Yulisha Byrow
Following extensive research exercise has emerged as an effective treatment for major depressive disorder, and it is now a recognised therapy alongside other interventions. In contrast, there is a paucity of research examining the therapeutic effects of exercise for those with bipolar disorder. Given that dysfunctional reward processing is central to bipolar disorder, research suggests that exercise can perhaps be framed as a reward-related event that may have the potential to precipitate a manic episode. The behavioural activation system (BAS) is a neurobehavioural system that is associated with responding to reward and provides an appropriate framework to theoretically examine and better understand the effects of exercise treatment on bipolar disorder...
November 2016: Evidence-based Mental Health
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