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https://www.readbyqxmd.com/read/29436856/chondroitinase-abc-for-neurological-recovery-after-acute-brain-injury-systematic-review-and-meta-analyses-of-preclinical-studies
#1
Chan Hee Koh, Savva Pronin, Mark Hughes
OBJECTIVES: Damage to critical brain regions causes deficits in important neurological functions. Chondroitinase ABC (ChABC) has been shown to promote neuroplasticity and may ameliorate neurological deficits caused by disease or trauma. This systematic review identifies and evaluates preclinical studies of ChABC as a treatment for acute brain injury. METHODS: Four databases were searched for studies relating to ChABC and brain or brain injuries. Controlled studies in mammals with acute brain injuries treated with ChABC were included in meta-analyses of neurobehavioural outcomes...
February 13, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29431110/the-personal-genome-project-canada-findings-from-whole-genome-sequences-of-the-inaugural-56-participants
#2
Miriam S Reuter, Susan Walker, Bhooma Thiruvahindrapuram, Joe Whitney, Iris Cohn, Neal Sondheimer, Ryan K C Yuen, Brett Trost, Tara A Paton, Sergio L Pereira, Jo-Anne Herbrick, Richard F Wintle, Daniele Merico, Jennifer Howe, Jeffrey R MacDonald, Chao Lu, Thomas Nalpathamkalam, Wilson W L Sung, Zhuozhi Wang, Rohan V Patel, Giovanna Pellecchia, John Wei, Lisa J Strug, Sherilyn Bell, Barbara Kellam, Melanie M Mahtani, Anne S Bassett, Yvonne Bombard, Rosanna Weksberg, Cheryl Shuman, Ronald D Cohn, Dimitri J Stavropoulos, Sarah Bowdin, Matthew R Hildebrandt, Wei Wei, Asli Romm, Peter Pasceri, James Ellis, Peter Ray, M Stephen Meyn, Nasim Monfared, S Mohsen Hosseini, Ann M Joseph-George, Fred W Keeley, Ryan A Cook, Marc Fiume, Hin C Lee, Christian R Marshall, Jill Davies, Allison Hazell, Janet A Buchanan, Michael J Szego, Stephen W Scherer
BACKGROUND: The Personal Genome Project Canada is a comprehensive public data resource that integrates whole genome sequencing data and health information. We describe genomic variation identified in the initial recruitment cohort of 56 volunteers. METHODS: Volunteers were screened for eligibility and provided informed consent for open data sharing. Using blood DNA, we performed whole genome sequencing and identified all possible classes of DNA variants. A genetic counsellor explained the implication of the results to each participant...
February 5, 2018: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/29419423/neurobehavioural-symptoms-and-acute-pesticide-poisoning-a-cross-sectional-study-among-male-pesticide-applicators-selected-from-three-commercial-farming-systems-in-ethiopia
#3
Beyene Negatu, Roel Vermeulen, Yalemtshay Mekonnen, Hans Kromhout
OBJECTIVE: To estimate prevalence of acute pesticide poisoning (APP) and its association with neurobehavioural symptoms in Ethiopian pesticide applicators. METHODS: We performed a cross-sectional survey among 256 pesticide applicators from small-scale irrigated farms, a large-scale open farm and large-scale greenhouses. APP was ascertained using a modified WHO case definition, and neurobehavioural symptoms were collected with a standardised questionnaire (Q16). Exposure to pesticides was estimated using detailed exposure algorithms specifically developed for Ethiopian farms...
February 1, 2018: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29402402/effects-of-strategic-early-morning-caffeine-gum-administration-on-association-between-salivary-alpha-amylase-and-neurobehavioural-performance-during-50%C3%A2-h-of-sleep-deprivation
#4
Maja Pajcin, Jason M White, Siobhan Banks, Jill Dorrian, Gemma M Paech, Crystal L Grant, Kayla Johnson, Katie Tooley, Eugene Aidman, Justin Fidock, Gary H Kamimori, Chris B Della Vedova
Self-assessment is the most common method for monitoring performance and safety in the workplace. However, discrepancies between subjective and objective measures have increased interest in physiological assessment of performance. In a double-blind placebo-controlled study, 23 healthy adults were randomly assigned to either a placebo (n = 11; 5 F, 6 M) or caffeine condition (n = 12; 4 F, 8 M) while undergoing 50 h (i.e. two days) of total sleep deprivation. In previous work, higher salivary alpha-amylase (sAA) levels were associated with improved psychomotor vigilance and simulated driving performance in the placebo condition...
February 2, 2018: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29400374/the-role-of-4d-us-in-evaluation-of-fetal-movements-and-facial-expressions-and-their-relationship-with-fetal-neurobehaviour
#5
REVIEW
Mihaela Grigore, Dumitru Gafitanu, Demetra Socolov, AnaMaria Grigore, Georgiana Nemeti, Romeo Micu
The introduction of four-dimensional (4D) ultrasonography (US) allows the study of fetal movements and facial expressions in real time. The possibility of evaluating fetal movements has led to the study of fetal neurobehaviour, which has been for a long period of time a mystery for physicians. The study of fetal activity in utero could differentiate between normal and abnormal behavioural patterns, thus making possible the early recognition of fetal brain impairment. Facial expressions observed with 4D US represent a marker for neurobehaviour and at the same time could enhance fetal-maternal bonding...
February 4, 2018: Medical Ultrasonography
https://www.readbyqxmd.com/read/29396173/the-neuropsychology-of-basal-ganglia
#6
REVIEW
Daria Riva, Matilde Taddei, Sara Bulgheroni
Basal ganglia are subcortical structures specialized at very early age, functionally different according to the right or left side. They are part of complex distributed network composed by parallel segregated loops where specific information are processed and open loops where different information are integrated. These loops are connected to specialized cortical areas thus entering into distributed processing of higher order cognitive functions and behaviours. Lesion or malfunction of basal ganglia nuclei cause deficits in different neuropsychological functions and neurobehavioural diseases, such Autism Spectrum Disorder, Attention Deficit/Hyperactivity Disorder, Tourette syndrome, etc...
January 12, 2018: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29382895/incubation-temperature-affects-the-expression-of-young-precocial-birds-fear-related-behaviours-and-neuroendocrine-correlates
#7
Aline Bertin, Ludovic Calandreau, Maryse Meurisse, Marion Georgelin, Rupert Palme, Sophie Lumineau, Cécilia Houdelier, Anne-Sophie Darmaillacq, Ludovic Dickel, Violaine Colson, Fabien Cornilleau, Christophe Rat, Joel Delaveau, Cécile Arnould
The influence of embryonic microclimate on the behavioural development of birds remains unexplored. In this study, we experimentally tested whether chronic exposure to suboptimal temperatures engendered plasticity in the expression of fear-related behaviours and in the expression of the corticotropin-releasing factor in the brains of domestic chicks (Gallus g. domesticus). We compared the neurobehavioural phenotypes of a control group of chicks incubated in an optimal thermal environment (37.8 °C) with those of a group of experimental chicks exposed chronically in ovo to suboptimal temperatures (27...
January 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29366823/data-driven-modelling-of-social-forces-and-collective-behaviour-in-zebrafish
#8
Adam K Zienkiewicz, Fabrizio Ladu, David A W Barton, Maurizio Porfiri, Mario Di Bernardo
Zebrafish are rapidly emerging as a powerful model organism in hypothesis-driven studies targeting a number of functional and dysfunctional processes. Mathematical models of zebrafish behaviour can inform the design of experiments, through the unprecedented ability to perform pilot trials on a computer. At the same time, in-silico experiments could help refining the analysis of real data, by enabling the systematic investigation of key neurobehavioural factors. Here, we establish a data-driven model of zebrafish social interaction...
January 20, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29364001/perceived-personality-change-after-traumatic-brain-injury-ii-comparing-participant-and-informant-perspectives
#9
Rodger A Weddell, Rodger Ll Wood
OBJECTIVE: The objective of this paper was to correlate informant personality change (PC) judgements following moderate-severe traumatic brain injury with quantitative neurobehavioural measures and to contrast the neurobehavioural correlates of informant and participant judgements of PC. PARTICIPANTS: Informant-participant pairs were recruited from a medico-legal clinic passing effort tests (N = 31) and a National Health Service clinic (N = 40). MEASURES: Participants were assessed on Wechsler tests of general ability, tests of executive functioning (Zoo Map and Fluency) and emotional distress (Beck Depression Inventory-FastScreen, Hospital Anxiety and Depression Scale and State-Trait Anger Expression Inventory-II)...
January 24, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29360998/concussion-microvascular-injury-and-early-tauopathy-in-young-athletes-after-impact-head-injury-and-an-impact-concussion-mouse-model
#10
Chad A Tagge, Andrew M Fisher, Olga V Minaeva, Amanda Gaudreau-Balderrama, Juliet A Moncaster, Xiao-Lei Zhang, Mark W Wojnarowicz, Noel Casey, Haiyan Lu, Olga N Kokiko-Cochran, Sudad Saman, Maria Ericsson, Kristen D Onos, Ronel Veksler, Vladimir V Senatorov, Asami Kondo, Xiao Z Zhou, Omid Miry, Linnea R Vose, Katisha R Gopaul, Chirag Upreti, Christopher J Nowinski, Robert C Cantu, Victor E Alvarez, Audrey M Hildebrandt, Erich S Franz, Janusz Konrad, James A Hamilton, Ning Hua, Yorghos Tripodis, Andrew T Anderson, Gareth R Howell, Daniela Kaufer, Garth F Hall, Kun P Lu, Richard M Ransohoff, Robin O Cleveland, Neil W Kowall, Thor D Stein, Bruce T Lamb, Bertrand R Huber, William C Moss, Alon Friedman, Patric K Stanton, Ann C McKee, Lee E Goldstein
The mechanisms underpinning concussion, traumatic brain injury, and chronic traumatic encephalopathy, and the relationships between these disorders, are poorly understood. We examined post-mortem brains from teenage athletes in the acute-subacute period after mild closed-head impact injury and found astrocytosis, myelinated axonopathy, microvascular injury, perivascular neuroinflammation, and phosphorylated tau protein pathology. To investigate causal mechanisms, we developed a mouse model of lateral closed-head impact injury that uses momentum transfer to induce traumatic head acceleration...
January 18, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29339966/acute-diesel-exhaust-exposure-and-postural-stability-a-controlled-crossover-experiment
#11
Jason Curran, Rachel Cliff, Nadine Sinnen, Michael Koehle, Chris Carlsten
Recent epidemiological evidence connects ambient air pollutants to adverse neurobehavioural effects in adults. In animal models, subchronic controlled exposures to diesel exhaust (DE) have also showed evidence of neuroinflammation. Evidence suggests that DE not only affects outcomes commonly associated with cognitive dysfunction, but also balance impairment. We conducted a controlled human exposure experiment with 28 healthy subjects (average age = 28 years (SD = 7.1; range = 21-49); and 40% female) who were exposed to two conditions, filtered air (FA) and DE (300 μg PM2...
2018: Journal of Occupational Medicine and Toxicology
https://www.readbyqxmd.com/read/29321841/reversed-gender-ratio-of-autism-spectrum-disorder-in-smith-magenis-syndrome
#12
Heidi Elisabeth Nag, Ann Nordgren, Britt-Marie Anderlid, Terje Nærland
Background: A substantial amount of research shows a higher rate of autistic type of problems in males compared to females. The 4:1 male to female ratio is one of the most consistent findings in autism spectrum disorder (ASD).Lately, the interest in studying ASD in genetic disorders has increased, and research has shown a higher prevalence of ASD in some genetic disorders than in the general population.Smith-Magenis syndrome (SMS) is a rare and complex genetic syndrome caused by an interstitial deletion of chromosome 17p11...
2018: Molecular Autism
https://www.readbyqxmd.com/read/29317348/paediatric-in-hospital-cardiac-arrest-factors-associated-with-survival-and-neurobehavioural-outcome-one-year-later
#13
Kathleen Meert, Russell Telford, Richard Holubkov, Beth S Slomine, James R Christensen, John Berger, George Ofori-Amanfo, Christopher J L Newth, J Michael Dean, Frank W Moler
OBJECTIVE: To investigate clinical characteristics associated with 12-month survival and neurobehavioural function among children recruited to the Therapeutic Hypothermia after Paediatric Cardiac Arrest In-Hospital trial. METHODS: Children (n = 329) with in-hospital cardiac arrest who received chest compressions for ≥2 min, were comatose, and required mechanical ventilation after return of circulation were included. Neurobehavioural function was assessed using the Vineland Adaptive Behaviour Scales, second edition (VABS-II) at baseline (reflecting pre-arrest status) and 12 months post-arrest...
January 6, 2018: Resuscitation
https://www.readbyqxmd.com/read/29306822/celecoxib-a-cyclooxygenase-2-inhibitor-offers-chemoprevention-against-reproductive-and-neurobehavioural-abnormalities-induced-by-atrazine-in-male-wistar-rats
#14
O E Kale, T O Oyesola, F S Raji
The cyclooxygenase-2/prostanoid pathway (COX-2) serves as a potential therapeutic target in various pathological conditions. Thus, the modulatory effect of celecoxib (CXB), a COX-2 inhibitor, in atrazine-induced toxicity was investigated. Five groups (n = 6 rats per group) of adult male Wistar rats received corn oil (2 ml/kg), atrazine (ATZ, 300 mg/kg) and CXB (5.7 mg/kg) respectively and their combinations via the oral route. Results obtained showed reduced (p < 0.05) sperm motility (25.8%) and counts (27...
December 30, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29305927/neurobehavioural-outcomes-in-children-after-in-hospital-cardiac-arrest
#15
Beth S Slomine, Faye S Silverstein, James R Christensen, Richard Holubkov, Russell Telford, J Michael Dean, Frank W Moler
AIM: Children who remain comatose after in-hospital cardiac arrest (IH-CA) resuscitation are at risk for poor neurological outcome. We report results of detailed neurobehavioural testing in paediatric IH-CA survivors, initially comatose after return of circulation, and enrolled in THAPCA-IH, a clinical trial that evaluated two targeted temperature management interventions (hypothermia, 33.0 °C or normothermia, 36.8 °C; NCT00880087). METHODS: Children, aged 2 days to <18 years, were enrolled in THAPCA-IH from 2009-2015; primary trial outcome (survival with favorable neurobehavioural outcome) did not differ between groups...
January 3, 2018: Resuscitation
https://www.readbyqxmd.com/read/29288974/jobelyn%C3%A2-attenuates-inflammatory-responses-and-neurobehavioural-deficits-associated-with-complete-freund-adjuvant-induced-arthritis-in-mice
#16
Osarume Omorogbe, Abayomi M Ajayi, Benneth Ben-Azu, Ejiroghene E Oghwere, Adaeze Adebesin, Adegbuyi O Aderibigbe, Olajuwon Okubena, Solomon Umukoro
Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects the physical and psychosocial wellbeing of the patients and a major cause of work disability. Current drugs for its treatment only provide palliative effect, as cure for the disease still remains elusive. Jobelyn® (JB), a potent anti-oxidant and anti-inflammatory dietary supplement obtained from Sorghum bicolor, has been claimed to relieve arthritic pain. Thus, this study was designed to evaluate its effect on inflammatory and biochemical changes as well as neurobehavioural deficits associated with complete Freund-adjuvant (CFA)-induced arthritis in mice...
December 27, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29284109/morin-hydrate-mitigates-rapid-eye-movement-sleep-deprivation-induced-neurobehavioural-impairments-and-loss-of-viable-neurons-in-the-hippocampus-of-mice
#17
Elizabeth T Olonode, Adegbuyi O Aderibigbe, Olusegun A Adeoluwa, Anthony T Eduviere, Benneth Ben-Azu
Rapid eye movement sleep deprivation distorts the body's homeostasis and results in oxidative breakdown which may be responsible for a variety of neurological disorders. Some naturally occurring compounds of plant origin with antioxidant and neuroprotective properties are known to attenuate the detrimental effects of REM sleep deprivation. Morin hydrate, a flavonoid from Mulberry has demonstrated antioxidant and neuroprotective activities but its effect in sleep disturbed mice is unknown. The study was designed to explore the neuroprotective effect of Morin hydrate on 48 hr...
December 25, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29196052/ferulic-acid-loaded-nanostructured-lipid-carriers-a-promising-nanoformulation-against-the-ischemic-neural-injuries
#18
Parichehr Hassanzadeh, Elham Arbabi, Fatemeh Atyabi, Rassoul Dinarvand
AIMS: Treatment of the ischemic stroke has remained a major healthcare challenge. The phenolic compound, ferulic acid (FA), has shown promising antioxidant and neuroprotective effects, however, low bioavailability may negatively affect its efficiency. This, prompted us to incorporate FA into the nanostructured lipid carriers (FA-NLCs) and evaluate its therapeutic potential in in vitro and in vivo models of ischemic stroke. MAIN METHODS: FA-NLCs were prepared by high-pressure homogenization followed by physicochemical characterization, evaluation of the bioactivity of FA-NLCs in oxygen-glucose deprivation (OGD) and global cerebral ischemia/reperfusion (I/R) injury and implication of phosphatidylinositol 3-kinase (PI3K) pathway in this regard...
November 28, 2017: Life Sciences
https://www.readbyqxmd.com/read/29190147/when-normal-scores-don-t-equate-to-independence-recalibrating-ratings-of-neurobehavioural-disability-from-the-st-andrew-s-swansea-neurobehavioural-outcome-scale-to-reflect-context-dependent-support
#19
Nick Alderman, Claire Williams, Rodger Ll Wood
PRIMARY OBJECTIVE: Context is critical to the interpretation of measurement instruments that capture acquired brain injury (ABI) outcomes. Ratings reflect behaviours and abilities observed in a particular setting; it cannot be assumed that results are generalizable beyond these. This study explored the utility of a method to convey the impact of context-dependent support given on ratings of neurobehavioural disability (NBD) using the St Andrews-Swansea Neurobehavioural Outcome Scale (SASNOS)...
2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29173065/neurobehavioural-effects-of-lactobacillus-rhamnosus-gg-alone-and-in-combination-with-prebiotics-polydextrose-and-galactooligosaccharide-in-male-rats-exposed-to-early-life-stress
#20
Karen-Anne McVey Neufeld, Siobhain M O'Mahony, Alan E Hoban, Rosaline V Waworuntu, Brian M Berg, Timothy G Dinan, John F Cryan
Early life is a period of significant brain development when the brain is at its most plastic and vulnerable. Stressful episodes during this window of development have long-lasting effects on the central nervous system. Rodent maternal separation (MS) is a reliable model of early-life stress and induces alterations in both physiology and behaviour. Intriguingly, the gut microbiota of MS offspring differ from that of non-separated offspring, suggesting a mechanistic role for the microbiota-gut-brain axis. Hence, we tested whether dietary factors known to affect the gut microbiota alter the neurobehavioural effects of MS...
November 27, 2017: Nutritional Neuroscience
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