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https://www.readbyqxmd.com/read/27908630/non-linear-dose-response-of-aluminium-hydroxide-adjuvant-particles-selective-low-dose-neurotoxicity
#1
Guillemette Crépeaux, Housam Eidi, Marie-Odile David, Yasmine Baba-Amer, Eleni Tzavara, Bruno Giros, François-Jérôme Authier, Christopher Exley, Christopher A Shaw, Josette Cadusseau, Romain K Gherardi
Aluminium (Al) oxyhydroxide (Alhydrogel(®)), the main adjuvant licensed for human and animal vaccines, consists of primary nanoparticles that spontaneously agglomerate. Concerns about its safety emerged following recognition of its unexpectedly long-lasting biopersistence within immune cells in some individuals, and reports of chronic fatigue syndrome, cognitive dysfunction, myalgia, dysautonomia and autoimmune/inflammatory features temporally linked to multiple Al-containing vaccine administrations. Mouse experiments have documented its capture and slow transportation by monocyte-lineage cells from the injected muscle to lymphoid organs and eventually the brain...
November 28, 2016: Toxicology
https://www.readbyqxmd.com/read/27891609/role-of-trpm7-in-cerebral-ischaemia-and-hypoxia
#2
Hong-Shuo Sun
Transient receptor potential melastatin 7 (TRPM7) channel, a calcium-permeable non-selective divalent cation channel, is broadly expressed in various cells and tissues, including the brain. TRPM7 is thought to be coupled to the metabolic state and regulate calcium homeostasis in the cell. TRPM7 takes part in a wide range of cell biology processes that affect cell growth and proliferation, as well as in embryonic development and skeleton formation. TRPM7 plays a significant role in ischaemic and hypoxic brain injury and neuronal cell death...
November 27, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27889232/l-methionine-and-silymarin-a-comparison-of-prophylactic-protective-capabilities-in-acetaminophen-induced-injuries-of-the-liver-kidney-and-cerebral-cortex
#3
Olakunle J Onaolapo, Moses A Adekola, Taiwo O Azeez, Karimat Salami, Adejoke Y Onaolapo
We compared the relative protective abilities of silymarin and l-methionine pre-treatment in acetaminophen overdose injuries of the liver, kidney and cerebral cortex by assessing behaviours, antioxidant status, tissue histological changes and biochemical parameters of hepatic/renal function. Rats were divided into six groups of ten each; animals in five of these groups were pre-treated with oral distilled water, silymarin (25mg/kg) or l-methionine (2.5, 5 and 10mg/kg body weight) for 14days; and then administered intraperitoneal (i...
November 23, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27878417/neurobehavioural-evaluation-of-resveratrol-in-murine-models-of-anxiety-and-schizophrenia
#4
Mohammed Garba Magaji, Loretta Oghenekome Iniaghe, Mutiat Abolarin, Opeyemi Isa Abdullahi, Rabiu Abdusalam Magaji
Resveratrol, a caloric restriction mimetic, is a naturally occurring polyphenolic compound with antioxidant and anti-inflammatory properties. Oxidative stress has been implicated in the etiology of a number of neuropsychiatric disorders including generalized anxiety and schizophrenia. This study investigated the anxiolytic and antipsychotic potentials of resveratrol in murine models of anxiety and schizophrenia. Mice were pretreated with resveratrol (200 and 400 mg/kg) in 1% carboxymethyl cellulose for 14 days and subjected to behavioural tests on the 15th day...
November 22, 2016: Metabolic Brain Disease
https://www.readbyqxmd.com/read/27857130/early-life-exposure-to-edcs-role-in-childhood-obesity-and-neurodevelopment
#5
REVIEW
Joseph M Braun
Endocrine-disrupting chemicals (EDCs) might increase the risk of childhood diseases by disrupting hormone-mediated processes that are critical for growth and development during gestation, infancy and childhood. The fetus, infant and child might have enhanced sensitivity to environmental stressors such as EDCs due to their rapid development and increased exposure to some EDCs as a consequence of development-specific behaviour, anatomy and physiology. In this Review, I discuss epidemiological studies examining the relationship between early-life exposure to bisphenol A (BPA), phthalates, triclosan and perfluoroalkyl substances (PFAS) with childhood neurobehavioural disorders and obesity...
November 18, 2016: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/27834333/effect-of-lamotrigine-levetiracetam-topiramate-on-neurobehavioural-parameters-oxidative-stress-in-comparison-with-valproate-in-rats
#6
Sudhir Chandra Sarangi, Ashish Kumar Kakkar, Ritesh Kumar, Yogendra Kumar Gupta
BACKGROUND & OBJECTIVES: Though newer antiepileptic drugs are considered safer than conventional antiepileptics, the effects of lamotrigine, levetiracetam and topiramate on neurobehavioural functions are yet to be established. This study evaluated neurobehavioural parameters and oxidative stress markers in brain tissue of rats treated with lamotrigine, levetiracetam and topiramate compared to sodium valproate . METHODS: Five groups of male Wistar rats were treated respectively with normal saline (control), sodium valproate (370 mg/kg), lamotrigine (50 mg/kg), levetiracetam (310 mg/kg) and topiramate (100 mg/kg) for 45 days...
July 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27812507/gene-expression-in-the-mouse-brain-following-early-pregnancy-exposure-to-ethanol
#7
Christine R Zhang, Suyinn Chong
Exposure to alcohol during early embryonic or fetal development has been linked with a variety of adverse outcomes, the most common of which are structural and functional abnormalities of the central nervous system [1]. Behavioural and cognitive deficits reported in individuals exposed to alcohol in utero include intellectual impairment, learning and memory difficulties, diminished executive functioning, attention problems, poor motor function and hyperactivity [2]. The economic and social costs of these outcomes are substantial and profound [3], [4]...
December 2016: Genomics Data
https://www.readbyqxmd.com/read/27810782/effect-of-l-pglu-1-benzyl-l-his-l-pro-nh2-against-in-vitro-and-in-vivo-models-of-cerebral-ischemia-and-associated-neurological-disorders
#8
Satyendra K Rajput, Arun K Sharma, Chhuttan L Meena, Aditya B Pant, Rahul Jain, Shyam S Sharma
Central nervous system plays a vital role in regulation of most of biological functions which are abnormally affected in various disorders including cerebral ischemia, Alzheimer's and Parkinson's (AD and PD) worldwide. Cerebral stroke is an extremely fatal and one of the least comprehensible neurological disorders due to limited availability of prospective clinical approaches and therapeutics. Since, some endogenous peptides like thyrotropin-releasing hormone have shown substantial neuroprotective potential, hence present study evaluates the newer thyrotropin-releasing hormone (TRH) analogue L-pGlu-(1-benzyl)-l-His-l-Pro-NH2 for its neuroprotective effects against oxygen glucose deprivation (OGD), glutamate and H2O2 induced injury in pheochromocytoma cell lines (PC-12 cells) and in-vivo ischemic injury in mice...
October 27, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27778335/neurobehaviour-at-term-in-infants-born-moderately-and-late-preterm-is-associated-with-cognition-at-2-years
#9
Mijna Hadders-Algra
No abstract text is available yet for this article.
October 25, 2016: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/27778080/richtwerte-f%C3%A3-r-toluol-und-gesundheitliche-bewertung-von-c7-c8-alkylbenzolen-in-der-innenraumluft-mitteilung-des-ausschusses-f%C3%A3-r-innenraumrichtwerte
#10
(no author information available yet)
The German Committee on Indoor Guide Values issues indoor air guide values to protect public health. For health evaluation of inhaled toluene a number of valid studies in humans is available. Toluene is a neurotoxic substance and the guide values are based on deficits in neurobehavioural tests observed at workers with chronic exposure of 337 mg toluene/m³. For the derivation of guide values the assumed continuous exposure is considered by a factor of 4.2, the interindividual variability by a factor of 10 and the elevated respiratory rate in children as compared to adults by a factor of 2...
November 2016: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/27775148/neurobehaviour-at-term-equivalent-age-and-neurodevelopmental-outcomes-at-2-years-in-infants-born-moderate-to-late-preterm
#11
Alicia J Spittle, Jennifer M Walsh, Cody Potter, Emma Mcinnes, Joy E Olsen, Katherine J Lee, Peter J Anderson, Lex W Doyle, Jeanie L Y Cheong
AIM: To examine the association between newborn neurobehavioural assessments and neurodevelopmental outcomes at 2 years in infants born moderate-to-late preterm (MLPT). METHOD: Two-hundred and one infants born MLPT (born 32-36(+6) wks' gestation) were assessed with the Hammersmith Neonatal Neurological Examination (HNNE) and NICU Network Neurobehavioral Scale (NNNS), with suboptimal performance defined as scores lower than the 10th centile. Development was assessed at 2 years corrected age with the Bayley Scales of Infant and Toddler Development 3rd Edition, with delay defined as scores less than 1 standard deviation (SD) below the mean...
October 24, 2016: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/27744650/household-interventions-for-preventing-domestic-lead-exposure-in-children
#12
REVIEW
Barbara Nussbaumer-Streit, Berlinda Yeoh, Ursula Griebler, Lisa M Pfadenhauer, Laura K Busert, Stefan K Lhachimi, Szimonetta Lohner, Gerald Gartlehner
BACKGROUND: Lead poisoning is associated with physical, cognitive and neurobehavioural impairment in children, and trials have tested many household interventions to prevent lead exposure. This is an update of the original review, first published in 2008. OBJECTIVES: To assess the effects of household interventions for preventing or reducing lead exposure in children, as measured by improvements in cognitive and neurobehavioural development, reductions in blood lead levels and reductions in household dust lead levels...
October 16, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27737812/solvent-neurotoxicity-in-vehicle-collision-repair-workers-in-new-zealand
#13
Samuel Keer, Bill Glass, Bradley Prezant, David McLean, Neil Pearce, Elizabeth Harding, Diana Echeverria, James McGlothlin, Duncan R Babbage, Jeroen Douwes
OBJECTIVES: To assess whether solvent use and workplace practices in the vehicle collision repair industry are associated with symptoms of neurotoxicity in spray painters and panel beaters (auto body repair workers). METHODS: Neurobehavioural symptoms were assessed using a cross-sectional study design in 370 vehicle collision repair and 211 reference workers using the EUROQUEST questionnaire. Full-shift airborne solvent levels were measured in a subset (n=92) of collision repair workers...
October 11, 2016: Neurotoxicology
https://www.readbyqxmd.com/read/27725106/latent-toxoplasmosis-is-associated-with-neurocognitive-impairment-in-young-adults-with-and-without-chronic-hiv-infection
#14
L Ene, T D Marcotte, A Umlauf, C Grancea, A Temereanca, A Bharti, C L Achim, S Letendre, S M Ruta
We evaluated the impact of latent toxoplasmosis (LT) on neurocognitive (NC) and neurobehavioural functioning in young adults with and without chronic HIV infection, using a standardised NC test battery, self-reported Beck Depression Inventory, Frontal System Behavior Scale, MINI-International Neuropsychiatric Interview and risk-assessment battery. 194 young adults (median age 24years, 48.2% males) with chronic HIV infection (HIV+) since childhood and 51 HIV seronegative (HIV-) participants were included. HIV+ individuals had good current immunological status (median CD4: 479 cells/μl) despite a low CD4 nadir (median: 93 cells/μl)...
October 15, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27720132/sex-specific-influence-on-the-relationship-between-maternal-exposures-to-persistent-chemicals-and-birth-outcomes
#15
Anna Carita Callan, Andrea Lee Hinwood, Jane Heyworth, Duong Trong Phi, Jon Ø Odland
Prenatal exposure to persistent pollutants has been associated with adverse birth outcomes, although few studies have investigated the influence of the sex of the infant. Sex specific differences have been associated with neurobehavioural impacts from environmental exposures with limited and contrary findings in relation to persistent pollutants. This study investigated the relationships between maternal exposure to a range of metals, polychlorinated biphenyls and pesticides measured in biological samples and birth outcomes with a specific focus on the sex of the infant...
September 28, 2016: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/27679680/exercising-control-over-bipolar-disorder
#16
Gin S Malhi, Yulisha Byrow
Following extensive research exercise has emerged as an effective treatment for major depressive disorder, and it is now a recognised therapy alongside other interventions. In contrast, there is a paucity of research examining the therapeutic effects of exercise for those with bipolar disorder. Given that dysfunctional reward processing is central to bipolar disorder, research suggests that exercise can perhaps be framed as a reward-related event that may have the potential to precipitate a manic episode. The behavioural activation system (BAS) is a neurobehavioural system that is associated with responding to reward and provides an appropriate framework to theoretically examine and better understand the effects of exercise treatment on bipolar disorder...
September 27, 2016: Evidence-based Mental Health
https://www.readbyqxmd.com/read/27678088/neurobehavioural-sequelae-of-social-deprivation-in-rodents-revisited-modelling-social-adversity-for-developmental-neuropsychiatric-disorders
#17
T W Robbins
The significance of investigating effects of deprivation of social experience in rodents is reviewed in the context of the review by Robbins et al. (1996) in the Journal of Psychopharmacology (10: 39-47). The early development of the paradigm by which rats were reared post-weaning in social isolation is described and compared with other early experience manipulations. The specification of the neural and behavioural phenotype of the isolate is brought up-to-date, focusing on changes in motivation and cognitive function, as well as on contrasting changes in the dopamine and serotonin systems, and in cortical (including hippocampal) structure and function...
November 2016: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/27671123/concussion-and-its-neurobehavioural-sequelae
#18
Silvana Riggio, Andy Jagoda
A concussion results from a force to the brain that results in a transient loss of connectivity within the brain. Sport psychiatrists are increasingly called to be part of the concussion team and need to be prepared to manage issues related to concussion and its behavioural sequelae. Objectively, the best evidence available suggests that deficits in attention and/or in balance are the most reliable objective findings that a concussion has occurred. Prognosis after a concussion is generally very good, although a sub-set of patients that are yet well defined seem pre-disposed to delayed recovery...
September 27, 2016: International Review of Psychiatry
https://www.readbyqxmd.com/read/27668457/sleep-quality-chronotype-and-social-jetlag-differentially-associate-with-symptoms-of-attention-deficit-hyperactivity-disorder-in-adults
#19
Niall M McGowan, Bogdan I Voinescu, Andrew N Coogan
Attention deficit hyperactivity disorder (ADHD) is a common neurobehavioural disorder which has been associated with sleep and circadian rhythm disturbances. Numerous studies have linked evening circadian typology with traits and behaviours associated with the disorder, although a precise reason for this relationship has not been clarified. The current study examines ADHD symptoms, impulsivity, cognitive failures, sleep quality and chronotype in a cohort of healthy young adults (N = 396). Results show significant, small magnitude associations between mid-point of sleep on free days, social jetlag (SJL) and ADHD symptoms and impulsivity, although not with cognitive failures...
2016: Chronobiology International
https://www.readbyqxmd.com/read/27658980/leukoencephalopathy-and-long-term-neurobehavioural-neurocognitive-and-brain-imaging-outcomes-in-survivors-of-childhood-acute-lymphoblastic-leukaemia-treated-with-chemotherapy-a-longitudinal-analysis
#20
Yin Ting Cheung, Noah D Sabin, Wilburn E Reddick, Deepa Bhojwani, Wei Liu, Tara M Brinkman, John O Glass, Scott N Hwang, Deokumar Srivastava, Ching-Hon Pui, Leslie L Robison, Melissa M Hudson, Kevin R Krull
BACKGROUND: Leukoencephalopathy is observed in some children undergoing chemotherapy for acute lymphoblastic leukaemia, although its effects on long-term outcomes is unknown. This study examines the associations between acute leukoencephalopathy and neurobehavioural, neurocognitive, and brain white matter imaging outcomes in long-term survivors of childhood acute lymphoblastic leukaemia treated with chemotherapy without cranial radiation. METHODS: In this longitudinal analysis, we used data of children with acute lymphoblastic leukaemia at St Jude Children's Research Hospital (Memphis, TN, USA) who had been treated between June 1, 2000, and Oct 31, 2010...
October 2016: Lancet Haematology
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