keyword
MENU ▼
Read by QxMD icon Read
search

neurobehavioural

keyword
https://www.readbyqxmd.com/read/29901413/melatonin-as-a-treatment-after-traumatic-brain-injury-a-systematic-review-and-meta-analysis-of-the-pre-clinical-and-clinical-literature
#1
Karen Barlow, Michael M J Esser, Myra Veidt, Roslyn Boyd
Traumatic brain injury is common and yet effective treatments of the secondary brain injury are scarce. Melatonin is a potent, non-selective neuroprotective and anti-inflammatory agent that is showing promising results in neonatal brain injury. The aim of this study was to systematically evaluate the pre-clinical and clinical literature for the effectiveness of Melatonin to improve outcome after TBI. Using the systematic review protocol for animal intervention studies (SYRCLE) and Cochrane methodology for clinical studies, a search of English articles was performed...
June 14, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29887685/improvement-of-2-vessel-occlusion-cerebral-ischaemia-reperfusion-induced-corticostriatal-electrolyte-and-redox-imbalance-lactic-acidosis-and-modified-acetylcholinesterase-activity-by-kolaviron-correlates-with-reduction-in-neurobehavioural-deficits
#2
Afolabi Clement Akinmoladun, Ibrahim Olabayode Saliu, Boyede Dele Olowookere, Olubukola Benedicta Ojo, Mary Tolulope Olaleye, Ebenezer Olatunde Farombi, Afolabi Akintunde Akindahunsi
Background: Disruption of electrolyte, redox and neurochemical homeostasis alongside cellular energy crisis is a hallmark of cerebral ischaemia and reperfusion injury. Purpose: This study investigated the effect of kolaviron (KV) on cortical and striatal cation imbalance, oxidative stress and neurochemical disturbances as well as neurobehavioural deficits in animals subjected to bilateral common carotid artery occlusion (BCCAO)-induced ischaemia/reperfusion injury...
April 2018: Annals of Neurosciences
https://www.readbyqxmd.com/read/29868772/brain-bioenergetics-during-resting-wakefulness-are-related-to-neurobehavioural-deficits-in-severe-obstructive-sleep-apnea-a-31p-magnetic-resonance-spectroscopy-study
#3
Angela L D'Rozario, Delwyn J Bartlett, Keith K H Wong, Toos Sach, Qiao Yang, Ronald R Grunstein, Caroline D Rae
Study Objectives: Obstructive sleep apnea (OSA) is a well-established cause of impaired daytime functioning. However, there is a complex inter-individual variability in neurobehavioural performance in OSA patients. We previously reported compromised brain bioenergetics during apneic sleep in severe OSA. In this study, we investigate whether brain bioenergetics during resting wakefulness are related to neurobehavioural performance. Methods: Patients attended the sleep laboratory in the evening and were kept awake over-night...
June 1, 2018: Sleep
https://www.readbyqxmd.com/read/29868603/impaired-neurobehavioural-performance-in-untreated-obstructive-sleep-apnea-patients-using-a-novel-standardised-test-battery
#4
Angela L D'Rozario, Clarice J Field, Camilla M Hoyos, Sharon L Naismith, George C Dungan, Keith K H Wong, Ronald R Grunstein, Delwyn J Bartlett
Objective/Background: Although polysomnography (PSG) is the gold-standard measure for assessing disease severity in obstructive sleep apnea (OSA), it has limited value in identifying individuals experiencing significant neurobehavioural dysfunction. This study used a brief and novel computerised test battery to examine neurobehavioural function in adults with and without OSA. Patients/Methods: 204 patients with untreated OSA [age 49.3 (12.5) years; body mass index, [BMI] 33...
2018: Frontiers in Surgery
https://www.readbyqxmd.com/read/29864411/lixisenatide-ameliorates-cerebral-ischemia-reperfusion-injury-via-glp-1-receptor-dependent-independent-pathways
#5
Rania G Abdel-Latif, Gehan H Heeba, Ashraf Taye, Mohamed M A Khalifa
Ischemic stroke is a major cause of neurological damage and brain dysfunction with consequent strong cerebral oxidative imbalance, inflammatory and apoptotic responses. Lixisenatide is a new potent glucagon-like peptide -1 (GLP-1) analogue that has been used clinically in the treatment of type II diabetes. Recent studies suggested the beneficial central effects of GLP-1-based therapies on different neurodegenerative diseases. This study aimed to investigate the ameliorative effect of lixisenatide in global cerebral ischemia-reperfusion (I/R) rat model and elaborate the underline mechanisms that could mediate the proposed activity...
June 1, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29862505/global-development-and-adaptive-behaviour-in-children-with-early-onset-epilepsy-a-population-based-case-control-study
#6
Colin Reilly, Patricia Atkinson, Ayesha Memon, Chloe Jones, Lyvia Dabydeen, Krishna B Das, Christopher Gillberg, Brian G R Neville, J Matthew Mahoney, Rod C Scott
AIM: There are limited population-based data on global development and adaptive behaviour in children with early-onset epilepsy. The aims of this study were: (1) to identify the prevalence of deficits in global development and adaptive behaviour experienced by children with early-onset epilepsy; (2) to identify factors associated with such deficits; and (3) to compare the relationship between measures of neurodevelopment in the group with epilepsy to a group without epilepsy who had other neurological or neurodevelopmental difficulties...
June 3, 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29808510/caffeine-dosing-strategies-to-optimize-alertness-during-sleep-loss
#7
Francisco G Vital-Lopez, Sridhar Ramakrishnan, Tracy J Doty, Thomas J Balkin, Jaques Reifman
Sleep loss, which affects about one-third of the US population, can severely impair physical and neurobehavioural performance. Although caffeine, the most widely used stimulant in the world, can mitigate these effects, currently there are no tools to guide the timing and amount of caffeine consumption to optimize its benefits. In this work, we provide an optimization algorithm, suited for mobile computing platforms, to determine when and how much caffeine to consume, so as to safely maximize neurobehavioural performance at the desired time of the day, under any sleep-loss condition...
May 28, 2018: Journal of Sleep Research
https://www.readbyqxmd.com/read/29782960/the-acute-and-residual-effects-of-escalating-analgesic-range-doses-of-ketamine-on-driving-performance-a-simulator-study
#8
Amie C Hayley, Maja Green, Luke A Downey, Con K K Stough, Michael Keane, Brook Shiferaw, Panagiota Kostakis, Yahya Shehabi
Ketamine hydrochloride elicits potent psychotomimetic and neurobehavioural effects which make it incompatible with driving; however, the direct effect on driving performance is yet to be assessed. Using an open label, within-subjects protocol, 15 males and 5 females (mean age = 30.8 years) were administered three fixed, stepwise increasing sub-anaesthetic doses of intravenous (IV) ketamine solution [(i) 8 mg/h IV infusion plus 30 mg bolus, (ii) 12 mg/h IV infusion and (iii) 20 mg/h infusion]. Whole blood ketamine and norketamine concentrations were determined at each treatment step and at 2 h post-infusion...
May 18, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29735386/neurobehavioural-outcome-in-6-18-year-old-children-after-trauma-in-pregnancy-case-control-study
#9
B J van der Knoop, K J Oostrom, I A Zonnenberg, M M van Weissenbruch, R J Vermeulen, J I P de Vries
BACKGROUND: Maternal trauma complicates pregnancy in approximately 7%. Long-term development of children exposed to maternal trauma is unknown. AIM: To determine neurobehavioural outcome of children (6-18 years) born after maternal trauma in pregnancy compared to a matched control group. STUDY DESIGN: Case-control study performed at a tertiary medical centre. SUBJECTS: All consecutive children born after maternal hospitalization for trauma during pregnancy between 1995 and 2005...
April 12, 2018: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29724871/anteromedial-thalamic-infarct-a-rare-presentation
#10
Syed H Shabbir, Faryal Nadeem, Daniel Labovitz
We report a rare presentation of an anteromedial thalamic infarct in a 50-year-old woman with acute onset left eye ptosis, vertical gaze paresis and confusion. MRI identified an acute left anteromedial thalamic infarct with a severe left P1 stenosis. Thalamic infarcts are associated with marked neurobehavioural disturbances with dominant thalamic lesions causing language deficits, verbal perseveration, memory disturbances, abulia and disorientation. Ocular movement deficits can also be present and typically accompany paramedian lesions...
May 2, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29660377/apathy-following-traumatic-brain-injury-a-review
#11
Andrew Worthington, Rodger Ll Wood
Apathy is a common problem after traumatic brain injury (TBI) and can have a major impact on cognitive function, psychosocial outcome and engagement in rehabilitation. For scientists and clinicians it remains one of the least understood aspects of brain-behaviour relationships encompassing disturbances of cognition, motivation, emotion and action, and is variously an indication of organic brain disease or psychiatric disorder. Apathy can be both sign and symptom and has been proposed as a diagnosis in its own right as well as a secondary feature of other conditions...
April 13, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29603802/paediatric-antiepileptic-polytherapy-systematic-review-of-efficacy-and-neurobehavioural-effects-and-a-tertiary-centre-experience
#12
D Plevin, J Jureidini, S Howell, N Smith
AIM: This paper presents the prevalence of antiepileptic polytherapy at a single tertiary institution and systematically reviews the evidence base for its efficacy and neurobehavioural safety in children. METHOD: Prevalence of antiepileptic polypharmacy was determined from pharmacy dispensing records at a paediatric tertiary hospital and neurobehavioural comorbidities quantified through casenote review; comparison is made with studies evaluating the neurobehavioural safety of antiepileptic polytherapy, identified via systematic literature review...
March 30, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29601846/burden-of-caregiving-after-a-child-s-in-hospital-cardiac-arrest
#13
Kathleen Meert, Beth S Slomine, James R Christensen, Russell Telford, Richard Holubkov, J Michael Dean, Frank W Moler
OBJECTIVE: To describe caregiver burden among those whose children survive in-hospital cardiac arrest and have high risk of neurologic disability, and explore factors associated with burden during the first year post-arrest. METHODS: The study is a secondary analysis of the Therapeutic Hypothermia after Paediatric Cardiac Arrest In-Hospital (THAPCA-IH) trial. 329 children who had an in-hospital cardiac arrest, chest compressions for >2 min, and mechanical ventilation after return of circulation were recruited to THAPCA-IH...
March 27, 2018: Resuscitation
https://www.readbyqxmd.com/read/29595192/blockade-of-the-swelling-induced-chloride-current-attenuates-the-mouse-neonatal-hypoxic-ischemic-brain-injury-in-vivo
#14
Raymond Wong, Ahmed Abussaud, Joseph Wh Leung, Bao-Feng Xu, Fei-Ya Li, Sammen Huang, Nai-Hong Chen, Guan-Lei Wang, Zhong-Ping Feng, Hong-Shuo Sun
Activation of swelling-induced Cl- current (ICl,swell ) during neonatal hypoxia-ischemia (HI) may induce brain damage. Hypoxic-ischemic brain injury causes chronic neurological morbidity in neonates as well as acute mortality. In this study, we investigated the role of ICl,swell in hypoxic-ischemic brain injury using a selective blocker, 4-(2-butyl-6,7-dichloro-2-cyclopentylindan-1-on-5-yl) oxybutyric acid (DCPIB). In primary cultured cortical neurons perfusion of a 30% hypotonic solution activated ICl,swell , which was completely blocked by the application of DCPIB (10 μmol/L)...
May 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29569083/attention-deficit-hyperactivity-disorder-children-exhibit-an-impaired-accommodative-response
#15
Beatriz Redondo, Jesús Vera, Rubén Molina, José Antonio García, Miriam Ouadi, Antonio Muñoz-Hoyos, Raimundo Jiménez
PURPOSE: Attention-deficit/hyperactivity disorder (ADHD) is one of the most common paediatric neurobehavioural disorders causing multiple functional impairments in children. Based on the relationship between the neural system that controls attention and ocular dynamics, the present study compares the magnitude and variability of accommodation between a group of non-medicated ADHD children and an age-matched control group. METHODS: The magnitude and variability of the accommodative response were objectively measured in 36 children using the WAM-5500 autorefractometer for 90 consecutive seconds at three static viewing distances (500, 40, and 20 cm)...
May 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29559228/sensory-aspects-of-tourette-syndrome
#16
REVIEW
Joanna H Cox, Stefano Seri, Andrea E Cavanna
Motor and vocal tics have long been recognised as the core features of Tourette syndrome (TS). However, patients' first-person accounts have consistently reported that these involuntary motor manifestations have specific sensory correlates. These sensory symptoms are often described as feelings of mounting inner tension ("premonitory urges") and are transiently relieved by tic expression. Multimodal hypersensitivity to external stimuli, perceived as triggers and/or exacerbating factors for specific tic symptoms, is also commonly reported by patients with TS...
May 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29549603/low-grade-neuroinflammation-due-to-chronic-sleep-deprivation-results-in-anxiety-and-learning-and-memory-impairments
#17
Shaffi Manchanda, Harpal Singh, Taranjeet Kaur, Gurcharan Kaur
Chronic sleep loss/fragmentation prevalent in the current 24/7 society is associated with irreversible consequences on health and overall wellbeing. Various studies have well documented the ill effects of acute sleep loss on cognitive functions of individuals; however, the underlying mechanism behind the chronic sleep loss is yet to be explored. The present study was aimed to investigate whether chronic sleep deprivation (CSD) triggers anxiety-like behaviour and memory decline in male Wistar rats. Rats were sleep deprived by placing them over slowly rotating drum (2 rpm) for 18 h (between 4 pm and 10 am) followed by 6 h of recovery sleep for 21 consecutive days...
March 16, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29524570/calpeptin-is-neuroprotective-against-acrylamide-induced-neuropathy-in-rats
#18
Benyu Su, Qiangdong Guan, Miaomiao Wang, Ning Liu, Xiaomin Wei, Shue Wang, Xiwei Yang, Wenchong Jiang, Mengmeng Xu, Sufang Yu
The aim of this study is to explore the potent neuroprotective effect of calpeptin (CP) on neuron damage induced by acrylamide (ACR) and its mechanism. Behavioural indicators such as hind limb splay, rota-rod performance, and gait analysis were assessed weekly to evaluate neurobehavioural changes after ACR and/or CP administration. The histopathological alterations and the changes of μ-calpain, m-calpain, microtubule-associated protein 2 (MAP2), and α-tubulin and β-tubulin protein levels in spinal cord were determined...
May 1, 2018: Toxicology
https://www.readbyqxmd.com/read/29498298/deconstructing-autism-from-unitary-syndrome-to-contributory-developmental-endophenotypes
#19
John N Constantino
A recent generation of family studies has revealed that autism can be predicted from an array of neurobehavioural susceptibilities that are appreciable before the syndrome is diagnosed, and that each may be traceable to partially-independent sets of genetic variation. Some of these liabilities are not necessarily specific to ASD-those that are non-specific could account for a significant share of the 'missing heritability' of autism, would (by definition) contribute to pleiotropy, and relate to so-called 'co-morbidities', which are inappropriately named if they actually contribute to (or exacerbate) the severity of autism itself...
February 2018: International Review of Psychiatry
https://www.readbyqxmd.com/read/29483352/assessing-the-continuum-between-temperament-and-affective-illness-psychiatric-and-mathematical-perspectives
#20
REVIEW
William Sulis
Temperament of healthy people and mental illnesses, particularly affective disorders, have been conjectured to lie along a continuum of neurobehavioural regulation. Understanding the nature of this continuum may better inform the construction of taxonomies for both categories of behaviour. Both temperament and mental illness refer to patterns of behaviour that manifest over long time scales (weeks to years) and they appear to share many underlying neuroregulatory systems. This continuum is discussed from the perspectives of nonlinear dynamical systems theory, neurobiology and psychiatry as applied to understanding such multiscale time-series behaviour...
April 19, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
keyword
keyword
96814
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"