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https://www.readbyqxmd.com/read/28650335/development-of-ad-like-symptoms-following-co-administration-of-alcl3-and-d-gal-in-rats-a-neurochemical-biochemical-and-behavioural-study
#1
Laraib Liaquat, Saara Ahmad, Sadia Sadir, Zehra Batool, Saima Khaliq, Saiqa Tabassum, Shaista Emad, Syeda Madiha, Sidrah Shahzad, Saida Haider
Alzheimer's disease (AD) is an age-related neurodegenerative disorder associated with neurochemical and neurobehavioural alterations. Aluminium (Al) is considered as a contributing factor in the etiology of several neurodegenerative disorders like AD. D-galactose (D-gal) is a physiological nutrient but over supply induces some neurochemical and biochemical changes that exacerbate natural aging process. In this study, we aimed to develop AD animal model by co-administration of Al and D-gal in rats. Male albino Wistar rats were intraperitoneally injected with AlCl3 and D-gal at a dose of 150mg/kg and 300mg/kg respectively for one week...
March 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28630378/randomised-controlled-trial-of-the-efficacy-of-a-blue-enriched-light-intervention-to-improve-alertness-and-performance-in-night-shift-workers
#2
Tracey L Sletten, Suzanne Ftouni, Christian L Nicholas, Michelle Magee, Ronald R Grunstein, Sally Ferguson, David J Kennaway, Darren O'Brien, Steven W Lockley, Shantha M W Rajaratnam
OBJECTIVES: Night workers often experience high levels of sleepiness due to misalignment of the sleep-wake cycle from the circadian pacemaker, in addition to acute and chronic sleep loss. Exposure to light, in particular short wavelength light, can improve alertness and neurobehavioural performance. This randomised controlled trial examined the efficacy of blue-enriched polychromatic light to improve alertness and neurobehavioural performance in night workers. DESIGN: Participants were 71 night shift workers (42 males; 32...
June 19, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28612134/ketamine-induced-behavioural-and-brain-oxidative-changes-in-mice-an-assessment-of-possible-beneficial-effects-of-zinc-as-mono-or-adjunct-therapy
#3
Olakunle James Onaolapo, Olayemi Quyyom Ademakinwa, Temitayo Opeyemi Olalekan, Adejoke Yetunde Onaolapo
RATIONALE: We studied the influence of zinc, haloperidol or olanzapine on neurobehaviour (open-field, radial arm maze and elevated plus maze) and brain antioxidant status in vehicle- or ketamine-treated mice, with the aim of ascertaining the potentials of zinc in counteracting ketamine's effects. OBJECTIVES: Experiment 1 assessed the effects of zinc in healthy animals and the relative degrees of modulation of ketamine's effects by zinc, haloperidol or olanzapine, respectively...
June 14, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28607558/hashimoto-s-encephalopathy-presenting-with-unusual-behavioural-disturbances-in-an-adolescent-girl
#4
Murugan Selvaraj Karthik, Kulothungan Nandhini, Viswanath Subashini, Ramasamy Balakrishnan
Hashimoto's encephalopathy (HE) is a rare autoimmune disorder with neurological and neuropsychiatric manifestations and elevated titres of anti-thyroid antibodies. Here we are reporting a case of HE in a 19-year-old girl who presented with seizure-like episodes, confusion, and behavioural disturbances with catatonic symptoms such as posturing, echopraxia, echolalia, and ambivalence. Patient did not respond to antipsychotics and anticonvulsants. On further investigation, patient was found to have high serum anti-TPO antibodies of about 1261 U/mL with euthyroid status, which supported a suspicion of HE...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28596566/high-dose-maternal-folic-acid-supplementation-before-conception-impairs-reversal-learning-in-offspring-mice
#5
Kristin S Henzel, Devon P Ryan, Susanne Schröder, Marco Weiergräber, Dan Ehninger
Maternal folic acid (FA) supplementation prior to and during gestation is recommended for the prevention of neural tube closure defects in the developing embryo. Prior studies, however, suggested that excessive FA supplementation during gestation can be associated with toxic effects on the developing organism. Here, we address whether maternal dietary folic acid supplementation at 40 mg/kg chow (FD), restricted to a period prior to conception, affects neurobehavioural development in the offspring generation...
June 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28595097/neuropredictors-of-oromotor-feeding-impairment-in-12month-old-children
#6
Katherine Sanchez, Angela T Morgan, Justine M Slattery, Joy E Olsen, Katherine J Lee, Peter J Anderson, Deanne K Thompson, Lex W Doyle, Jeanie L Y Cheong, Alicia J Spittle
BACKGROUND: Feeding impairment is prevalent in children with neurodevelopmental issues. Neuroimaging and neurobehavioural outcomes at term are predictive of later neuromotor impairment, but it is unknown whether they predict feeding impairment. AIMS: To determine whether neurobehavior and brain magnetic resonance imaging (MRI) at term predict oromotor feeding at 12months in preterm and term-born children. STUDY DESIGN: Prospective cohort study...
June 5, 2017: Early Human Development
https://www.readbyqxmd.com/read/28511367/neurobehavioural-changes-in-a-hemiparkinsonian-rat-model-induced-by-rotenone
#7
REVIEW
Sukala Puthuparambil Maniyath, Narayanan Solaiappan, Muthusamy Rathinasamy
INTRODUCTION: Rotenone, a mitochondrial complex I inhibitor is used as a neurotoxin agent to reproduce the neuropathological, and behavioural feature of Parkinson's Disease (PD) in rat. Due to acute and chronic exposure of rotenone with various doses through different routes of administration, mortality is being reported. Low dose takes a longer duration to produce PD symptoms in animals. This present study was designed to create hemiparkinsonian 'partial' lesion model by rotenone at a single moderate dose in two sites of striatum in albino rats and also to assess its toxicity by behavioural parameters and by microscopic study...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28498556/adaptive-and-maladaptive-functioning-in-kleefstra-syndrome-compared-to-other-rare-genetic-disorders-with-intellectual-disabilities
#8
Karlijn Vermeulen, Anneke de Boer, Joost G E Janzing, David A Koolen, Charlotte W Ockeloen, Marjolein H Willemsen, Floor M Verhoef, Patricia A M van Deurzen, Linde van Dongen, Hans van Bokhoven, Jos I M Egger, Wouter G Staal, Tjitske Kleefstra
Detailed neurobehavioural profiles are of major value for specific clinical management, but have remained underexposed in the population with intellectual disabilities (ID). This was traditionally classified based on IQ level only. Rapid advances in genetics enable etiology based stratification in the majority of patients, which reduces clinical heterogeneity. This paper illustrates that specific profiles can be obtained for rare syndromes with ID. Our main aim was to study (mal)adaptive functioning in Kleefstra Syndrome (KS) by comparing and contrasting our findings to three other subgroups: Koolen-de Vries Syndrome, GATAD2B-related syndrome, and a mixed control group of individuals with ID...
May 12, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28488395/shorter-duration-of-non-rapid-eye-movement-sleep-slow-waves-in-epha4-knockout-mice
#9
Marlène Freyburger, Gaétan Poirier, Julie Carrier, Valérie Mongrain
Slow waves occurring during non-rapid eye movement sleep have been associated with neurobehavioural performance and memory. In addition, the duration of previous wakefulness and sleep impacts characteristics of these slow waves. However, molecular mechanisms regulating the dynamics of slow-wave characteristics remain poorly understood. The EphA4 receptor regulates glutamatergic transmission and synaptic plasticity, which have both been linked to sleep slow waves. To investigate if EphA4 regulates slow-wave characteristics during non-rapid eye movement sleep, we compared individual parameters of slow waves between EphA4 knockout mice and wild-type littermates under baseline conditions and after a 6-h sleep deprivation...
May 10, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28482003/coenzyme-q10-reduces-sevoflurane-induced-cognitive-deficiency-in-young-mice
#10
G Xu, H Lu, Y Dong, D Shapoval, S G Soriano, X Liu, Y Zhang, Z Xie
Background.: Anaesthesia can induce cognitive deficiency in young rodents and monkeys. Mitochondrial dysfunction contributes to the anaesthesia-induced neurotoxicity and neurobehavioural deficits. We therefore assessed the effects of the mitochondrial energy enhancer coenzyme Q 10 (CoQ 10 ) on anaesthesia-induced cognitive deficiency in young mice to investigate the role of mitochondrial dysfunction. Methods.: Young mice ( n =134) were randomly assigned into the following four groups: control plus corn oil vehicle (60% oxygen); 3% sevoflurane [2 h daily on postnatal day (P) 6, 7, and 8] plus vehicle; CoQ 10 (50 mg kg -1 ) plus vehicle; or 3% sevoflurane plus CoQ 10 plus vehicle...
May 7, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28481889/abnormal-neurobehaviour-and-impaired-memory-function-as-a-consequence-of-toxocara-canis-as-well-as-toxocara-cati-induced-neurotoxocarosis
#11
Elisabeth Janecek, Patrick Waindok, Marion Bankstahl, Christina Strube
BACKGROUND: Neuroinvasive larvae of the worldwide occurring zoonotic roundworms Toxocara canis and T. cati may induce neurotoxocarosis (NT) in humans, provoking a variety of symptoms including cognitive deficits as well as neurological dysfunctions. An association with neuropsychological disorders has been discussed. Similar symptoms have been described in T. canis-infected mice, whereas data on T. cati-induced NT are rare. Therefore, it was aimed to obtain insights into the impact on neurobehaviour as well as progression of neurological symptoms and behavioural alterations during the course of NT directly comparing T...
May 8, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28452420/neurobehavioural-and-cognitive-development-in-infants-born-to-mothers-with-eating-disorders
#12
M Barona, E Taborelli, F Corfield, S Pawlby, A Easter, U Schmidt, J Treasure, N Micali
INTRODUCTION: Although recent research has focused on the effects of maternal eating disorders (EDs) on children, little is known about the effect of maternal EDs on neurobiological outcomes in newborns and infants. This study is the first to investigate neurobehavioural regulation and cognitive development in newborns and infants of mothers with EDs. METHODS: Women with an active and past ED and healthy controls were recruited to a prospective longitudinal study during their first trimester or second trimester of pregnancy...
April 28, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28449646/when-is-the-use-of-pacifiers-justifiable-in-the-baby-friendly-hospital-initiative-context-a-clinician-s-guide
#13
Welma Lubbe, Wilma Ten Ham-Baloyi
BACKGROUND: The use of pacifiers is an ancient practice, but often becomes a point of debate when parents and professionals aim to protect and promote breastfeeding as most appropriately for nurturing infants. We discuss the current literature available on pacifier use to enable critical decision-making regarding justifiable use of pacifiers, especially in the Baby-Friendly Hospital Initiative context, and we provide practical guidelines for clinicians. DISCUSSION: Suck-swallow-breathe coordination is an important skill that every newborn must acquire for feeding success...
April 27, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28436072/real-time-individualization-of-the-unified-model-of-performance
#14
Jianbo Liu, Sridhar Ramakrishnan, Srinivas Laxminarayan, Thomas J Balkin, Jaques Reifman
Existing mathematical models for predicting neurobehavioural performance are not suited for mobile computing platforms because they cannot adapt model parameters automatically in real time to reflect individual differences in the effects of sleep loss. We used an extended Kalman filter to develop a computationally efficient algorithm that continually adapts the parameters of the recently developed Unified Model of Performance (UMP) to an individual. The algorithm accomplishes this in real time as new performance data for the individual become available...
April 24, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28426381/hyperbaric-oxygen-for-experimental-intracerebral-haemorrhage-systematic-review-and-stratified-meta-analysis
#15
Han-Jin Cui, Hao-Yu He, A-Li Yang, Hua-Jun Zhou, Tao Tang, Jie-Kun Luo
OBJECTIVE: Hyperbaric oxygen (HBO) is widely used in treating various neurological diseases. However, HBO for treatment of intracerebral haemorrhage (ICH) remains controversial, in either animal or clinical studies. Therefore, we conducted this systematic review and meta-analysis on studies describing the efficacy of HBO in animal models of ICH. METHODS: Studies were identified by searching mainstream databases through November 2015. The efficacy of HBO in animal models of ICH was assessed by changes in the brain water content (BWC), neurobehavioural outcome (NO) or both...
2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28385478/quantitative-electroencephalogram-measures-in-adult-obstructive-sleep-apnea-potential-biomarkers-of-neurobehavioural-functioning
#16
REVIEW
Angela L D'Rozario, Nathan E Cross, Andrew Vakulin, Delwyn J Bartlett, Keith K H Wong, David Wang, Ronald R Grunstein
Obstructive sleep apnea (OSA) results in significantly impaired cognitive functioning and increased daytime sleepiness in some patients leading to increased risk of motor vehicle and workplace accidents and reduced productivity. Clinicians often face difficulty in identifying which patients are at risk of neurobehavioural dysfunction due to wide inter-individual variability, and disparity between symptoms and conventional metrics of disease severity such as the apnea hypopnea index. Quantitative electroencephalogram (EEG) measures are determinants of awake neurobehavioural function in healthy subjects...
October 19, 2016: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/28383632/measuring-change-in-symptoms-of-neurobehavioural-disability-responsiveness-of-the-st-andrew-s-swansea-neurobehavioural-outcome-scale
#17
Nick Alderman, Claire Williams, Caroline Knight, Rodger Ll Wood
Objective: Neurobehavioural disability (NBD) after acquired brain injury (ABI) is often associated with poor outcome. The "St Andrew's-Swansea Neurobehavioural Outcome Scale" (SASNOS) was developed to measure NBD in a range of applications. Two of the "holy trinity" of psychometric properties, reliability and validity, have been comprehensively mapped, but the extent to which SASNOS meets the third, responsiveness, has not been investigated. Demonstrating responsiveness is essential in instruments employed in repeated measurement scenarios to confirm their ability to discriminate real change from error...
April 5, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28381599/identifying-genes-for-neurobehavioural-traits-in-rodents-progress-and-pitfalls
#18
REVIEW
Amelie Baud, Jonathan Flint
Identifying genes and pathways that contribute to differences in neurobehavioural traits is a key goal in psychiatric research. Despite considerable success in identifying quantitative trait loci (QTLs) associated with behaviour in laboratory rodents, pinpointing the causal variants and genes is more challenging. For a long time, the main obstacle was the size of QTLs, which could encompass tens if not hundreds of genes. However, recent studies have exploited mouse and rat resources that allow mapping of phenotypes to narrow intervals, encompassing only a few genes...
April 1, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28379220/long-term-consumption-of-fermented-rooibos-herbal-tea-offers-neuroprotection-against-ischemic-brain-injury-in-rats
#19
Olusiji Akinrinmade, Sylvester Omoruyi, Daneel Dietrich, Okobi Ekpo
Stroke is the second leading cause of death worldwide, affecting about 240 people a day in South Africa and leaving survivors with residual disabilities. At the moment, there is no clinically approved neuroprotective product for stroke but the consumption of plant polyphenols has been suggested to offer some protection against stroke. In this study, we investigated the effects of long-term consumption of fermented rooibos herbal tea (FRHT) on ischemia/reperfusion (I/R)-induced brain injury in adult male Wistar rats...
2017: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/28377299/some-properties-of-an-adjusting-magnitude-schedule-of-reinforcement-implications-for-models-of-choice
#20
C M Bradshaw
Rats were trained under a discrete-trials adjusting-magnitude schedule in which a response on lever A delivered either a larger or a smaller reinforcer (qA1 and qA2) with equal probability, while a response on B delivered a reinforcer whose size qB was adjusted according to the rats' choices. When A was preferred in a given block of trials, qB was increased in the following block; when B was preferred, qB was reduced in the following block. The oscillating changes in qB, analysed by the Fourier transform, could be described by a power spectrum with a dominant period of about 50 trial blocks...
April 2, 2017: Behavioural Processes
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