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https://www.readbyqxmd.com/read/28204778/a-randomized-controlled-trial-to-evaluate-the-role-of-brief-delay-in-cord-clamping-in-preterm-neonates-34-36-weeks-on-short-term-neurobehavioural-outcome
#1
Vikram Datta, Aditi Kumar, Reena Yadav
No abstract text is available yet for this article.
February 15, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/28186121/astrocyte-deletion-of-bmal1-alters-daily-locomotor-activity-and-cognitive-functions-via-gaba-signalling
#2
Olga Barca-Mayo, Meritxell Pons-Espinal, Philipp Follert, Andrea Armirotti, Luca Berdondini, Davide De Pietri Tonelli
Circadian rhythms are controlled by a network of clock neurons in the central pacemaker, the suprachiasmatic nucleus (SCN). Core clock genes, such as Bmal1, are expressed in SCN neurons and in other brain cells, such as astrocytes. However, the role of astrocytic clock genes in controlling rhythmic behaviour is unknown. Here we show that ablation of Bmal1 in GLAST-positive astrocytes alters circadian locomotor behaviour and cognition in mice. Specifically, deletion of astrocytic Bmal1 has an impact on the neuronal clock through GABA signalling...
February 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/28167858/relationship-between-lead-exposure-and-mild-cognitive-impairment
#3
C Fenga, S Gangemi, A Alibrandi, C Costa, E Micali
INTRODUCTION: Since it is still controversial whether-low-to moderate long-term lead below current threshold values causes neurobehavioural deficits in adults. METHODS: Forty lead-exposed workers subjects with a mean blood lead (PbB) level of 56.4 μg/dL and 40 non-lead-exposed aged matched subjects (PbB: 15.4 μg/dL) with the same socio-economic background were investigated. Participants were administered a neuropsychological tests consisting of BAMT (Branches Alternate Movements Task), FT (Finger Tapping Speed), DS (Digit Span) POMS (Profile of Mood States)...
December 2016: Journal of Preventive Medicine and Hygiene
https://www.readbyqxmd.com/read/28167839/new-murine-niemann-pick-type-c-models-bearing-a-pseudoexon-generating-mutation-recapitulate-the-main-neurobehavioural-and-molecular-features-of-the-disease
#4
Marta Gómez-Grau, Júlia Albaigès, Josefina Casas, Carme Auladell, Mara Dierssen, Lluïsa Vilageliu, Daniel Grinberg
Niemann-Pick disease type C (NPC) is a rare neurovisceral disease caused mainly by mutations in the NPC1 gene. This autosomal recessive lysosomal disorder is characterised by the defective lysosomal secretion of cholesterol and sphingolipids. No effective therapy exists for the disease. We previously described a deep intronic point mutation (c.1554-1009 G > A) in NPC1 that generated a pseudoexon, which could be corrected at the cellular level using antisense oligonucleotides. Here, we describe the generation of two mouse models bearing this mutation, one in homozygosity and the other in compound heterozygosity with the c...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28164996/personality-and-augmenting-reducing-a-r-in-auditory-event-related-potentials-erps-during-emotional-visual-stimulation
#5
Vilfredo De Pascalis, Francesca Fracasso, Philip J Corr
An auditory augmenting/reducing ERP paradigm recorded for 5 intensity tones with emotional visual stimulation was used, for the first time, to test predictions derived from the revised Reinforcement Sensitivity Theory (rRST) of personality with respect to two major factors: behavioral inhibition system (BIS), fight/flight/freeze system (FFFS). Higher BIS and FFFS scores were negatively correlated with N1/P2 slopes at central sites (C3, Cz, C4). Conditional process analysis revealed that the BIS was a mediator of the association between the N1/P2 slope and the FFFS scores...
February 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28160687/social-attention-in-children-with-epilepsy
#6
Judith Lunn, Tim Donovan, Damien Litchfield, Charlie Lewis, Robert Davies, Trevor Crawford
Children with epilepsy may be vulnerable to impaired social attention given the increased risk of neurobehavioural comorbidities. Social attentional orienting and the potential modulatory role of attentional control on the perceptual processing of gaze and emotion cues have not been examined in childhood onset epilepsies. Social attention mechanisms were investigated in patients with epilepsy (n=25) aged 8-18years old and performance compared to healthy controls (n=30). Dynamic gaze and emotion facial stimuli were integrated into an antisaccade eye-tracking paradigm...
February 1, 2017: Brain and Cognition
https://www.readbyqxmd.com/read/28160302/autism-spectrum-disorder-and-other-neurobehavioural-comorbidities-in-rare-disorders-of-the-ras-mapk-pathway
#7
Shruti Garg, Ami Brooks, Amy Burns, Emma Burkitt-Wright, Bronwyn Kerr, Susan Huson, Richard Emsley, Jonathan Green
AIM: To investigate the cognitive and behavioural phenotype in rare disorders of the Ras/MAPK pathway, namely Noonan, cardiofaciocutaneous (CFC), and Costello syndromes, particularly prevalence of autism spectrum disorder (ASD) and attention-deficit-hyperactivity disorder (ADHD). METHOD: Fifty children were recruited over 10 months through the regional genetics service and advertisements. A range of parent, child, and observational measures were administered including Autism Diagnostic Interview-Revised and Autism Diagnostic Observation Scale...
February 4, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28156141/factors-influencing-mother-child-communication-about-fathers-with-neurobehavioural-sequelae-after-brain-injury
#8
Shiho Takanashi, Mariko Sakka, Iori Sato, Shu Watanabe, Shota Tanaka, Ayumi Ooshio, Nobuhito Saito, Kiyoko Kamibeppu
OBJECTIVE: The present study clarified factors related to mother-child communication openness when fathers suffer neurobehavioural sequelae after stroke or traumatic brain injury. RESEARCH DESIGN: A cross-sectional study using self-report anonymous questionnaires was conducted. METHODS AND PROCEDURES: Forty-one mothers with 6-22-year-old children participated. The questionnaire examined personal factors (mother's psychological distress), social/family factors (family support functioning), illness-related factors (father's time at home and neurobehavioural sequelae severity) and mother's perceived level of open communication...
February 3, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28106136/long-term-exposure-to-835%C3%A2-mhz-rf-emf-induces-hyperactivity-autophagy-and-demyelination-in-the-cortical-neurons-of-mice
#9
Ju Hwan Kim, Da-Hyeon Yu, Yang Hoon Huh, Eun Ho Lee, Hyung-Gun Kim, Hak Rim Kim
Radiofrequency electromagnetic field (RF-EMF) is used globally in conjunction with mobile communications. There are public concerns of the perceived deleterious biological consequences of RF-EMF exposure. This study assessed neuronal effects of RF-EMF on the cerebral cortex of the mouse brain as a proxy for cranial exposure during mobile phone use. C57BL/6 mice were exposed to 835 MHz RF-EMF at a specific absorption rate (SAR) of 4.0 W/kg for 5 hours/day during 12 weeks. The aim was to examine activation of autophagy pathway in the cerebral cortex, a brain region that is located relatively externally...
January 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28103833/prevalence-of-attention-deficit-hyperactivity-disorder-among-children-and-adolescents-in-china-a-systematic-review-and-meta-analysis
#10
Tingting Wang, Kaihua Liu, Zhanzhan Li, Yang Xu, Yuan Liu, Wenpei Shi, Lizhang Chen
BACKGROUND: Attention deficit/hyperactivity disorder (ADHD), the most common childhood neurobehavioural disorder, can produce a series of negative effects on children, adolescents, and even adults as well as place a serious economic burden on families and society. However, the prevalence of ADHD is not well understood in China. The goal of this study was to estimate the pooled prevalence of ADHD among children and adolescents in China using a systematic review and meta-analysis. METHODS: A systematic literature search was conducted in PubMed, Web of Science, MEDLINE, CNKI, Wanfang, Weipu and CBM databases, and relevant articles published from inception to March 1, 2016, that provided the prevalence of ADHD among children and adolescents in China were reviewed...
January 19, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28103649/amlodipine-an-l-type-calcium-channel-blocker-protects-against-chlorpromazine-induced-neurobehavioural-deficits-in-mice
#11
Oluwafemi E Kale, Olufunsho Awodele, Temitope O Ogundare, Martins Ekor
The present study investigated the modulatory and chemopreventive benefit of amlodipine (AML), a dihydropyridine calcium channel antagonist, against neurobehavioural abnormalities (NAs) associated with chlorpromazine (CPZ) toxicity in mice. Adult mice were divided into five groups of 6 animals/group. Group 1 (control) was administered saline (10 ml/kg i.p.). Group 2 received CPZ (2 mg/kg i.p.). Groups 3 and 4 received bromocriptine (BMC, 2.5 mg/kg s.c.) and AML (1 mg/kg s.c.) respectively while group 5 received their combination...
January 19, 2017: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/28025035/resveratrol-suppresses-neuroinflammation-in-the-experimental-paradigm-of-autism-spectrum-disorders
#12
Ranjana Bhandari, Anurag Kuhad
BACKGROUND: Neuronal dysfunction caused by neuroinflammation triggered by the stimulation of matrix metalloproteinases and the subsequent release of pro-inflammatory cytokines, as a result of oxidative stress and mitochondrial dysfunction, is one of the probable mechanisms involved in the pathogenesis of autism spectrum disorders (ASD). The aim of the present study was to explore the ameliorative potential of resveratrol on neuroinflammation in the experimental paradigm of neuroinflammatory model of ASD in rats...
February 2017: Neurochemistry International
https://www.readbyqxmd.com/read/27974137/health-effects-associated-with-measured-levels-of-contaminants-in-the-arctic
#13
Pál Weihe, Fróði Debes, Jónrit Halling, Maria Skaalum Petersen, Gina Muckle, Jon Øyvind Odland, Alexey Dudarev, Pierre Ayotte, Éric Dewailly, Philippe Grandjean, Eva Bonefeld-Jørgensen
The Human Health Assessment Group has over the past decade recommended that effect studies be conducted in the circumpolar area. Such studies examine the association between contaminant exposure in the Arctic populations and health effects. Because foetuses and young children are the most vulnerable, effect studies are often prospective child cohort studies. The emphasis in this article is on a description of the effects associated with contaminant exposure in the Arctic. The main topics addressed are neurobehavioural, immunological, reproductive, cardiovascular, endocrine and carcinogenic effect...
2016: International Journal of Circumpolar Health
https://www.readbyqxmd.com/read/27922243/late-diagnosed-phenylketonuria-in-an-eight-year-old-boy-with-dyslexia-and-attention-deficit-hyperactivity-disorder
#14
Yılmaz Yıldız, Ali Dursun, Ayşegül Tokatlı, Turgay Coşkun, Hatice Serap Sivri
Phenylketonuria, previously a common cause of severe intellectual disability, is a metabolic disorder now promptly diagnosed and effectively treated thanks to newborn screening programs. Here, we report a male patient presenting with dyslexia and attention-deficit hyperactivity disorder, who was diagnosed with mild phenylketonuria at eight years of age. Earlier recognition and treatment before the establishment of irreversible brain damage would have resulted in better neurobehavioural outcomes. Classical phenylketonuria and milder phenotypes of phenylalanine hydroxylase deficiency need to be considered in the differential diagnosis of all cognitive and behavioural problems of unknown cause...
2016: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/27920084/caffeine-consumption-during-pregnancy-and-adhd-at-the-age-of-11%C3%A2-years-a-birth-cohort-study
#15
Bianca Del-Ponte, Iná S Santos, Luciana Tovo-Rodrigues, Luciana Anselmi, Tiago N Munhoz, Alicia Matijasevich
OBJECTIVE: Studies evaluating caffeine intake during pregnancy and long-term outcomes, such as the child's neurobehaviour, are still scarce and their results are inconsistent. The objective of the present study was to evaluate the association between maternal consumption of caffeine during pregnancy and attention deficit hyperactivity disorder (ADHD) at the age of 11 years. METHODOLOGY: All children born in the city of Pelotas, Brazil, during the year 2004, were selected for a cohort study...
December 5, 2016: BMJ Open
https://www.readbyqxmd.com/read/27908630/non-linear-dose-response-of-aluminium-hydroxide-adjuvant-particles-selective-low-dose-neurotoxicity
#16
Guillemette Crépeaux, Housam Eidi, Marie-Odile David, Yasmine Baba-Amer, Eleni Tzavara, Bruno Giros, François-Jérôme Authier, Christopher Exley, Christopher A Shaw, Josette Cadusseau, Romain K Gherardi
Aluminium (Al) oxyhydroxide (Alhydrogel(®)), the main adjuvant licensed for human and animal vaccines, consists of primary nanoparticles that spontaneously agglomerate. Concerns about its safety emerged following recognition of its unexpectedly long-lasting biopersistence within immune cells in some individuals, and reports of chronic fatigue syndrome, cognitive dysfunction, myalgia, dysautonomia and autoimmune/inflammatory features temporally linked to multiple Al-containing vaccine administrations. Mouse experiments have documented its capture and slow transportation by monocyte-lineage cells from the injected muscle to lymphoid organs and eventually the brain...
January 15, 2017: Toxicology
https://www.readbyqxmd.com/read/27891609/role-of-trpm7-in-cerebral-ischaemia-and-hypoxia
#17
Hong-Shuo Sun
Transient receptor potential melastatin 7 (TRPM7) channel, a calcium-permeable non-selective divalent cation channel, is broadly expressed in various cells and tissues, including the brain. TRPM7 is thought to be coupled to the metabolic state and regulate calcium homeostasis in the cell. TRPM7 takes part in a wide range of cell biology processes that affect cell growth and proliferation, as well as in embryonic development and skeleton formation. TRPM7 plays a significant role in ischaemic and hypoxic brain injury and neuronal cell death...
November 27, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27889232/l-methionine-and-silymarin-a-comparison-of-prophylactic-protective-capabilities-in-acetaminophen-induced-injuries-of-the-liver-kidney-and-cerebral-cortex
#18
COMPARATIVE STUDY
Olakunle J Onaolapo, Moses A Adekola, Taiwo O Azeez, Karimat Salami, Adejoke Y Onaolapo
We compared the relative protective abilities of silymarin and l-methionine pre-treatment in acetaminophen overdose injuries of the liver, kidney and cerebral cortex by assessing behaviours, antioxidant status, tissue histological changes and biochemical parameters of hepatic/renal function. Rats were divided into six groups of ten each; animals in five of these groups were pre-treated with oral distilled water, silymarin (25mg/kg) or l-methionine (2.5, 5 and 10mg/kg body weight) for 14days; and then administered intraperitoneal (i...
January 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27878417/neurobehavioural-evaluation-of-resveratrol-in-murine-models-of-anxiety-and-schizophrenia
#19
Mohammed Garba Magaji, Loretta Oghenekome Iniaghe, Mutiat Abolarin, Opeyemi Isa Abdullahi, Rabiu Abdusalam Magaji
Resveratrol, a caloric restriction mimetic, is a naturally occurring polyphenolic compound with antioxidant and anti-inflammatory properties. Oxidative stress has been implicated in the etiology of a number of neuropsychiatric disorders including generalized anxiety and schizophrenia. This study investigated the anxiolytic and antipsychotic potentials of resveratrol in murine models of anxiety and schizophrenia. Mice were pretreated with resveratrol (200 and 400 mg/kg) in 1% carboxymethyl cellulose for 14 days and subjected to behavioural tests on the 15th day...
November 22, 2016: Metabolic Brain Disease
https://www.readbyqxmd.com/read/27857130/early-life-exposure-to-edcs-role-in-childhood-obesity-and-neurodevelopment
#20
REVIEW
Joseph M Braun
Endocrine-disrupting chemicals (EDCs) might increase the risk of childhood diseases by disrupting hormone-mediated processes that are critical for growth and development during gestation, infancy and childhood. The fetus, infant and child might have enhanced sensitivity to environmental stressors such as EDCs due to their rapid development and increased exposure to some EDCs as a consequence of development-specific behaviour, anatomy and physiology. In this Review, I discuss epidemiological studies examining the relationship between early-life exposure to bisphenol A (BPA), phthalates, triclosan and perfluoroalkyl substances (PFAS) with childhood neurobehavioural disorders and obesity...
March 2017: Nature Reviews. Endocrinology
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