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https://www.readbyqxmd.com/read/28426381/hyperbaric-oxygen-for-experimental-intracerebral-haemorrhage-systematic-review-and-stratified-meta-analysis
#1
Han-Jin Cui, Hao-Yu He, A-Li Yang, Hua-Jun Zhou, Tao Tang, Jie-Kun Luo
OBJECTIVE: Hyperbaric oxygen (HBO) is widely used in treating various neurological diseases. However, HBO for treatment of intracerebral haemorrhage (ICH) remains controversial, in either animal or clinical studies. Therefore, we conducted this systematic review and meta-analysis on studies describing the efficacy of HBO in animal models of ICH. METHODS: Studies were identified by searching mainstream databases through November 2015. The efficacy of HBO in animal models of ICH was assessed by changes in the brain water content (BWC), neurobehavioural outcome (NO) or both...
2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28385478/quantitative-electroencephalogram-measures-in-adult-obstructive-sleep-apnea-potential-biomarkers-of-neurobehavioural-functioning
#2
REVIEW
Angela L D'Rozario, Nathan E Cross, Andrew Vakulin, Delwyn J Bartlett, Keith K H Wong, David Wang, Ronald R Grunstein
Obstructive sleep apnea (OSA) results in significantly impaired cognitive functioning and increased daytime sleepiness in some patients leading to increased risk of motor vehicle and workplace accidents and reduced productivity. Clinicians often face difficulty in identifying which patients are at risk of neurobehavioural dysfunction due to wide inter-individual variability, and disparity between symptoms and conventional metrics of disease severity such as the apnea hypopnea index. Quantitative electroencephalogram (EEG) measures are determinants of awake neurobehavioural function in healthy subjects...
October 19, 2016: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/28383632/measuring-change-in-symptoms-of-neurobehavioural-disability-responsiveness-of-the-st-andrew-s-swansea-neurobehavioural-outcome-scale
#3
Nick Alderman, Claire Williams, Caroline Knight, Rodger Ll Wood
Objective: Neurobehavioural disability (NBD) after acquired brain injury (ABI) is often associated with poor outcome. The "St Andrew's-Swansea Neurobehavioural Outcome Scale" (SASNOS) was developed to measure NBD in a range of applications. Two of the "holy trinity" of psychometric properties, reliability and validity, have been comprehensively mapped, but the extent to which SASNOS meets the third, responsiveness, has not been investigated. Demonstrating responsiveness is essential in instruments employed in repeated measurement scenarios to confirm their ability to discriminate real change from error...
April 5, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28381599/identifying-genes-for-neurobehavioural-traits-in-rodents-progress-and-pitfalls
#4
REVIEW
Amelie Baud, Jonathan Flint
Identifying genes and pathways that contribute to differences in neurobehavioural traits is a key goal in psychiatric research. Despite considerable success in identifying quantitative trait loci (QTLs) associated with behaviour in laboratory rodents, pinpointing the causal variants and genes is more challenging. For a long time, the main obstacle was the size of QTLs, which could encompass tens if not hundreds of genes. However, recent studies have exploited mouse and rat resources that allow mapping of phenotypes to narrow intervals, encompassing only a few genes...
April 1, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28379220/long-term-consumption-of-fermented-rooibos-herbal-tea-offers-neuroprotection-against-ischemic-brain-injury-in-rats
#5
Olusiji Akinrinmade, Sylvester Omoruyi, Daneel Dietrich, Okobi Ekpo
Stroke is the second leading cause of death worldwide, affecting about 240 people a day in South Africa and leaving survivors with residual disabilities. At the moment, there is no clinically approved neuroprotective product for stroke but the consumption of plant polyphenols has been suggested to offer some protection against stroke. In this study, we investigated the effects of long-term consumption of fermented rooibos herbal tea (FRHT) on ischemia/reperfusion (I/R)-induced brain injury in adult male Wistar rats...
2017: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/28377299/some-properties-of-an-adjusting-magnitude-schedule-of-reinforcement-implications-for-models-of-choice
#6
C M Bradshaw
Rats were trained under a discrete-trials adjusting-magnitude schedule in which a response on lever A delivered either a larger or a smaller reinforcer (qA1 and qA2) with equal probability, while a response on B delivered a reinforcer whose size qB was adjusted according to the rats' choices. When A was preferred in a given block of trials, qB was increased in the following block; when B was preferred, qB was reduced in the following block. The oscillating changes in qB, analysed by the Fourier transform, could be described by a power spectrum with a dominant period of about 50 trial blocks...
April 2, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28347572/the-effect-of-nefopam-on-lactation-after-caesarean-section-a-single-blind-randomised-trial
#7
N E Baka, F Vial, G Iohom, P Guerci, C Hubert, M Rouabah, H Bouaziz
BACKGROUND: Nefopam is a centrally acting analgesic which has a theoretical risk of stopping lactation due to its anticholinergic and dopaminergic effects. The aim of this study was to evaluate the effect of nefopam on lactation and to investigate potential adverse effects on newborns. METHODS: Seventy-two women, scheduled to undergo a caesarean delivery under spinal anaesthesia and wanting to breastfeed, were randomised to one of two groups: nefopam (20mg, six hourly) or paracetamol (1g, six hourly)...
February 20, 2017: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/28333406/survey-of-neurodevelopmental-allied-health-teams-in-australian-and-new-zealand-neonatal-nurseries-staff-profile-and-standardised-neurobehavioural-neurological-assessment
#8
Leesa G Allinson, Lex W Doyle, Linda Denehy, Alicia J Spittle
AIMS: The primary aim of this study was to establish how many neonatal nurseries in Australia and New Zealand had a neurodevelopmental allied health team, to ascertain the disciplines involved, their qualifications and experience. The secondary aim was to evaluate which standardised neurobehavioural/neurological assessments were currently being implemented, and the existing practice in relation to their use. METHODS: A descriptive cross-sectional survey, sampling 179 eligible public and private hospital neonatal intensive care units (NICUs) and special care nurseries (SCNs) throughout Australia and New Zealand, was purpose-developed and administered electronically from the 5th April to 23rd July 2013...
March 23, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28321581/neurobehavioural-toxicity-of-iron-oxide-nanoparticles-in-mice
#9
Vasanth Dhakshinamoorthy, Vijayprakash Manickam, Ekambaram Perumal
Iron oxide nanoparticles (Fe2O3-NPs) are widely used in various biomedical applications, extremely in neurotheranostics. Simultaneously, Fe2O3-NP usage is of alarming concern, as its exposure to living systems causes deleterious effects due to its redox potential. However, study on the neurobehavioural impacts of Fe2O3-NPs is very limited. In this regard, adult male mice were intraperitoneally administered with Fe2O3-NPs (25 and 50 mg/kg body weight) once a week for 4 weeks. A significant change in locomotor behaviour and spatial memory was observed in Fe2O3-NP-treated animals...
March 20, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28281492/comorbidities-of-epilepsy
#10
REVIEW
H V Srinivas, Urvashi Shah
In epilepsy management, control of seizures is the prime objective. However, the quality of life is affected by comorbid conditions that include the neurological, neuropsychiatric, and neurobehavioural disorders. These are not only reactive processes to a chronic condition but also have a bidirectional relationship, sharing common underlying pathogenesis. This article besides addressing these issues also explores the therapeutic management. A systematic search of PubMed from Jan 2006 to August 2016 was undertaken using the terms "comorbidities" and "epilepsy...
2017: Neurology India
https://www.readbyqxmd.com/read/28272498/the-differential-binding-of-antipsychotic-drugs-to-the-abc-transporter-p-glycoprotein-predicts-cannabinoid-antipsychotic-drug-interactions
#11
Natalia I Brzozowska, Erik J de Tonnerre, Kong M Li, Xiao Suo Wang, Aurelie A Boucher, Paul D Callaghan, Michael Kuligowski, Alex Wong, Jonathon C Arnold
Cannabis use increases rates of psychotic relapse and treatment failure in schizophrenia patients. Clinical studies suggest that cannabis use reduces the efficacy of antipsychotic drugs, however there has been no direct demonstration of this in a controlled study. The present study demonstrates that exposure to the principal phytocannabinoid, Δ(9)-tetrahydrocannabinol (THC), reverses the neurobehavioural effects of the antipsychotic drug risperidone in mice. THC exposure did not influence D2 and 5-HT2A receptor binding, the major targets of antipsychotic action, however lowered the brain concentrations of risperidone and its active metabolite, 9-hydroxy risperidone...
March 8, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28228044/withaferin-a-protects-against-spinal-cord-injury-by-inhibiting-apoptosis-and-inflammation-in-mice
#12
Xianlei Yan, Guangxiang Huang, Quan Liu, Jiemin Zheng, Hongmou Chen, Qidan Huang, Jiakang Chen, Heqing Huang
CONTEXT: Withaferin A (WFA) exhibits diverse pharmaceutical applications on human diseases, including rheumatoid arthritis, cancers and microbial infection. OBJECTIVE: We evaluated the neuroprotective role of WFA using a mouse model of spinal cord injury (SCI). MATERIALS AND METHODS: BALB/c mice were administrated 10 mg/kg of WFA. Gene expression was measured by real-time PCR, western blot and immunohistochemistry. Cell morphology and apoptosis were determined by H&E staining and TUNEL assay...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28224614/neurobehavioural-vulnerability-and-autistic-traits-in-rasopathies
#13
Yves Sznajer
No abstract text is available yet for this article.
February 22, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28204778/a-randomized-controlled-trial-to-evaluate-the-role-of-brief-delay-in-cord-clamping-in-preterm-neonates-34-36-weeks-on-short-term-neurobehavioural-outcome
#14
Vikram Datta, Aditi Kumar, Reena Yadav
No abstract text is available yet for this article.
February 15, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/28186121/astrocyte-deletion-of-bmal1-alters-daily-locomotor-activity-and-cognitive-functions-via-gaba-signalling
#15
Olga Barca-Mayo, Meritxell Pons-Espinal, Philipp Follert, Andrea Armirotti, Luca Berdondini, Davide De Pietri Tonelli
Circadian rhythms are controlled by a network of clock neurons in the central pacemaker, the suprachiasmatic nucleus (SCN). Core clock genes, such as Bmal1, are expressed in SCN neurons and in other brain cells, such as astrocytes. However, the role of astrocytic clock genes in controlling rhythmic behaviour is unknown. Here we show that ablation of Bmal1 in GLAST-positive astrocytes alters circadian locomotor behaviour and cognition in mice. Specifically, deletion of astrocytic Bmal1 has an impact on the neuronal clock through GABA signalling...
February 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/28167858/relationship-between-lead-exposure-and-mild-cognitive-impairment
#16
C Fenga, S Gangemi, A Alibrandi, C Costa, E Micali
INTRODUCTION: Since it is still controversial whether-low-to moderate long-term lead below current threshold values causes neurobehavioural deficits in adults. METHODS: Forty lead-exposed workers subjects with a mean blood lead (PbB) level of 56.4 μg/dL and 40 non-lead-exposed aged matched subjects (PbB: 15.4 μg/dL) with the same socio-economic background were investigated. Participants were administered a neuropsychological tests consisting of BAMT (Branches Alternate Movements Task), FT (Finger Tapping Speed), DS (Digit Span) POMS (Profile of Mood States)...
December 2016: Journal of Preventive Medicine and Hygiene
https://www.readbyqxmd.com/read/28167839/new-murine-niemann-pick-type-c-models-bearing-a-pseudoexon-generating-mutation-recapitulate-the-main-neurobehavioural-and-molecular-features-of-the-disease
#17
Marta Gómez-Grau, Júlia Albaigès, Josefina Casas, Carme Auladell, Mara Dierssen, Lluïsa Vilageliu, Daniel Grinberg
Niemann-Pick disease type C (NPC) is a rare neurovisceral disease caused mainly by mutations in the NPC1 gene. This autosomal recessive lysosomal disorder is characterised by the defective lysosomal secretion of cholesterol and sphingolipids. No effective therapy exists for the disease. We previously described a deep intronic point mutation (c.1554-1009 G > A) in NPC1 that generated a pseudoexon, which could be corrected at the cellular level using antisense oligonucleotides. Here, we describe the generation of two mouse models bearing this mutation, one in homozygosity and the other in compound heterozygosity with the c...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28164996/personality-and-augmenting-reducing-a-r-in-auditory-event-related-potentials-erps-during-emotional-visual-stimulation
#18
Vilfredo De Pascalis, Francesca Fracasso, Philip J Corr
An auditory augmenting/reducing ERP paradigm recorded for 5 intensity tones with emotional visual stimulation was used, for the first time, to test predictions derived from the revised Reinforcement Sensitivity Theory (rRST) of personality with respect to two major factors: behavioral inhibition system (BIS), fight/flight/freeze system (FFFS). Higher BIS and FFFS scores were negatively correlated with N1/P2 slopes at central sites (C3, Cz, C4). Conditional process analysis revealed that the BIS was a mediator of the association between the N1/P2 slope and the FFFS scores...
February 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28160687/social-attention-in-children-with-epilepsy
#19
Judith Lunn, Tim Donovan, Damien Litchfield, Charlie Lewis, Robert Davies, Trevor Crawford
Children with epilepsy may be vulnerable to impaired social attention given the increased risk of neurobehavioural comorbidities. Social attentional orienting and the potential modulatory role of attentional control on the perceptual processing of gaze and emotion cues have not been examined in childhood onset epilepsies. Social attention mechanisms were investigated in patients with epilepsy (n=25) aged 8-18years old and performance compared to healthy controls (n=30). Dynamic gaze and emotion facial stimuli were integrated into an antisaccade eye-tracking paradigm...
April 2017: Brain and Cognition
https://www.readbyqxmd.com/read/28160302/autism-spectrum-disorder-and-other-neurobehavioural-comorbidities-in-rare-disorders-of-the-ras-mapk-pathway
#20
Shruti Garg, Ami Brooks, Amy Burns, Emma Burkitt-Wright, Bronwyn Kerr, Susan Huson, Richard Emsley, Jonathan Green
AIM: To investigate the cognitive and behavioural phenotype in rare disorders of the Ras/MAPK pathway, namely Noonan, cardiofaciocutaneous (CFC), and Costello syndromes, particularly prevalence of autism spectrum disorder (ASD) and attention-deficit-hyperactivity disorder (ADHD). METHOD: Fifty children were recruited over 10 months through the regional genetics service and advertisements. A range of parent, child, and observational measures were administered including Autism Diagnostic Interview-Revised and Autism Diagnostic Observation Scale...
February 4, 2017: Developmental Medicine and Child Neurology
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