keyword
MENU ▼
Read by QxMD icon Read
search

Fungal cell wall inhibitor

keyword
https://www.readbyqxmd.com/read/29311246/candida-albicans-%C3%AE-glucan-containing-particles-increase-ho-1-expression-in-oral-keratinocytes-via-ros-p38mapk-nrf2-pathway
#1
Yoko Ishida, Kouji Ohta, Takako Naruse, Hiroki Kato, Akiko Fukui, Hideo Shigeishi, Hiromi Nishi, Kei Tobiume, Masaaki Takechi
Oral keratinocytes provide the first line of host defense against oral candidiasis. We speculated that interactions of fungal cell wall components with oral keratinocytes regulate stress response against Candida infection, and examined the expression of genes induced by heat-killed Candida albicans in oral immortalized keratinocytes using a cDNA microarray technique. Of 24,000 genes revealed by that analysis, we focused on HO-1, a stress-inducible gene, as its expression was increased by both heat-killed as well as live C...
January 8, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29205129/dissimilar-pigment-regulation-in-serpula-lacrymans-and-paxillus-involutus-during-inter-kingdom-interactions
#2
James P Tauber, Ramses Gallegos-Monterrosa, Ákos T Kovács, Ekaterina Shelest, Dirk Hoffmeister
Production of basidiomycete atromentin-derived pigments like variegatic acid (pulvinic acid-type) and involutin (diarylcyclopentenone) from the brown-rotter Serpula lacrymans and the ectomycorrhiza-forming Paxillus involutus, respectively, is induced by complex nutrition, and in the case of S. lacrymans, bacteria. Pigmentation in S. lacrymans was stimulated by 13 different bacteria and cell-wall-damaging enzymes (lytic enzymes and proteases), but not by lysozyme or mechanical damage. The use of protease inhibitors with Bacillus subtilis or heat-killed bacteria during co-culturing with S...
December 5, 2017: Microbiology
https://www.readbyqxmd.com/read/29193198/the-dna-methyltransferase-inhibitor-5-aza-2-deoxycytidine-affects-humicola-grisea-enzyme-activities-and-the-glucose-mediated-gene-repression
#3
João Heitor C Manfrão-Netto, Thiago M Mello-de-Sousa, Astrid R Mach-Aigner, Robert L Mach, Marcio J Poças-Fonseca
Humicola grisea var. thermoidea (Hgvt) is a thermophilic ascomycete that produces lignocellulolytic enzymes and it is proposed for the conversion of agricultural residues into useful byproducts. Drugs that inhibit the DNA methyltransferases (DNMTs) activity are employed in epigenetic studies but nothing is known about a possible effect on the production of fungal enzymes. We evaluated the effect of 5-aza-2'-deoxycytidine (5-Aza; a chemical inhibitor of DNMTs activity) on the secreted enzyme activity and on the transcription of cellulase and xylanase genes from Hgvt grown in agricultural residues and in glucose...
November 28, 2017: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/29167801/breaking-the-bad-bacillus-blocks-fungal-virulence-factors
#4
COMMENT
François L Mayer, James W Kronstad
Fungal pathogens rely on the production of specific virulence factors during infection. Inhibiting such factors generally results in reduced fungal pathogenicity. Most studies in the past have focused on understanding the molecular mechanisms of fungal virulence factor expression during mono-culture, or during interaction with the host. However, a potentially important, second type of interaction has been less well studied thus far - the interplay of fungal pathogens of humans with other microbes found in their natural habitat...
October 30, 2017: Microbial Cell
https://www.readbyqxmd.com/read/29164827/inhibitors-against-fungal-cell-wall-remodelling-enzymes
#5
Pedro Merino, Ignacio Delso, Jessika Valero-Gonzalez, Fernando Gomollon-Bel, Jorge Castro-Lopez, Wenxia Fang, Iva Navratilova, Daan M F van Aalten, Tomas Tejero, Ramon Hurtado-Guerrero
Fungal beta-1,3-glucan glucanosyltransferases are glucan-remodeling enzymes that play important roles in cell wall integrity, and are essential for the viability of pathogenic fungi/yeasts. As such, they are considered possible drug targets, although inhibitors of this class of enzymes have not yet been reported. Here, we report a multidisciplinary approach, based on a structure-guided design using a highly conserved transglycosylase from Sacharomyces cerevisiae, that leads to carbohydrate derivatives with high affinity for Aspergillus fumigatus Gel4...
November 22, 2017: ChemMedChem
https://www.readbyqxmd.com/read/29112179/green-ultrasound-versus-conventional-synthesis-and-characterization-of-specific-task-pyridinium-ionic-liquid-hydrazones-tethering-fluorinated-counter-anions-novel-inhibitors-of-fungal-ergosterol-biosynthesis
#6
Nadjet Rezki, Salsabeel A Al-Sodies, Sheikh Shreaz, Rayees Ahmad Shiekh, Mouslim Messali, Vaseem Raja, Mohamed R Aouad
A series of specific task ionic liquids (ILs) based on a pyridiniumhydrazone scaffold in combination with hexafluorophosphate (PF₆(-)), tetrafluoroboron (BF₄(-)) and/or trifluoroacetate (CF₃COO(-)) counter anion, were designed and characterized by IR, NMR and mass spectrometry. The reactions were conducted under both conventional and green ultrasound procedures. The antifungal potential of the synthesized compounds 2-25 was investigated against 40 strains of Candida (four standard and 36 clinical isolates)...
November 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29063476/fungal-%C3%AE-glucan-activates-the-nlrp3-inflammasome-in-human-bronchial-epithelial-cells-through-ros-production
#7
Yanhua Huang, Meng Hua, Xuefan Cui
The nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3) inflammasome has developed as an important bridge between innate immune and infection recently, and has the ability to drive proteolytic procaspase-1 into bioactive caspase-1, then responsible for proteolytic processing of inflammatory cytokines IL-1β and IL-18. Fungal β-glucan, a major component of fungal cell wall, triggers inflammatory response in multiple immune cells, but rarely described in epithelial cells. Also, the relationship between fungal β-glucan and NLRP3 inflammasome is not clear yet...
October 23, 2017: Inflammation
https://www.readbyqxmd.com/read/28981444/central-mediators-of-the-zymosan-induced-febrile-response
#8
Amanda Leite Bastos-Pereira, Daniel Fraga, Arturo Alejandro Dreifuss, Aleksander Roberto Zampronio
BACKGROUND: Zymosan is a fungal cell wall protein-carbohydrate complex that is known to activate inflammatory pathways through the Toll-like receptors and is commonly used to induce fever. Nevertheless, the central mediators that are involved in the zymosan-induced febrile response are only partially known. METHODS: The present study evaluated the participation of prostaglandins, substance P, endothelin-1 (ET-1), and endogenous opioids (eOPs) in the zymosan-induced febrile response by using inhibitors and antagonists in male Wistar rats...
November 27, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28968565/long-range-molecular-dynamics-study-of-interactions-of-the-eukaryotic-glucosamine-6-phosphate-synthase-with-fructose-6-phosphate-and-udp-glcnac
#9
Aleksandra Miszkiel, Marek Wojciechowski
Glucosamine-6-phosphate synthase (EC 2.6.1.16) is responsible for catalysis of the first and practically irreversible step in hexosamine metabolism. The final product of this pathway, uridine 5' diphospho N-acetyl-d-glucosamine (UDP-GlcNAc), is an essential substrate for assembly of bacterial and fungal cell walls. Moreover, the enzyme is involved in phenomenon of hexosamine induced insulin resistance in type II diabetes, which makes of it a potential target for anti-fungal, anti-bacterial and anti-diabetic therapy...
September 18, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28890395/the-antifungal-arsenal-alternative-drugs-and-future-targets
#10
Nathan P Wiederhold
Clinically available antifungals for the treatment of invasive fungal infections primarily target either ergosterol in the fungal cell membrane or 1,3-β-D-glucan in the fungal cell wall. These classes include the polyene amphotericin B, the triazoles, and the echinocandins. Although newer antifungals and improved formulations of others have advanced our ability to treat patients with invasive mycoses, these drugs are often limited by toxicities, drug interactions, and the need for intravenous administration...
September 7, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28791666/clinical-pharmacokinetics-and-pharmacodynamics-of-micafungin
#11
REVIEW
Roeland E Wasmann, Eline W Muilwijk, David M Burger, Paul E Verweij, Catherijne A Knibbe, Roger J Brüggemann
Micafungin is a selective inhibitor of the synthesis of fungal 1,3-β-D-glucan, an essential component of the fungal cell wall. It is available as a powder for infusion only and is registered for the treatment of invasive and esophageal candidiasis in addition to prophylaxis of Candida infections in both adults and children. Average exposure after a single intravenous 100 mg dose in healthy adults is 133 mg h/L. Both exposure and maximum plasma concentration show linear dose proportional pharmacokinetics (PK) over a 0...
August 8, 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/28783748/heat-shock-protein-90-localizes-to-the-surface-and-augments-virulence-factors-of-cryptococcus-neoformans
#12
Sharanya Chatterjee, Utpal Tatu
BACKGROUND: Thermotolerance is an essential attribute for pathogenesis of Cryptococcus as exemplified by the fact that only two species in the genus, which can grow at 37°C, are human pathogens. Species which have other virulence factors including capsule formation and melanisation, but lack the ability to propagate at 37°C are not pathogenic. In another related fungal pathogen, Candida albicans, heat shock protein 90 has been implicated to be a central player in commanding pathogenicity by governing yeast to hyphal transition and drug resistance...
August 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28611248/the-aspergillus-fumigatus-crza-transcription-factor-activates-chitin-synthase-gene-expression-during-the-caspofungin-paradoxical-effect
#13
Laure Nicolas Annick Ries, Marina Campos Rocha, Patrícia Alves de Castro, Rafael Silva-Rocha, Roberto Nascimento Silva, Fernanda Zanolli Freitas, Leandro José de Assis, Maria Célia Bertolini, Iran Malavazi, Gustavo H Goldman
Aspergillus fumigatus is an opportunistic fungal pathogen that causes invasive aspergillosis (IA), a life-threatening disease in immunocompromised humans. The echinocandin caspofungin, adopted as a second-line therapy in combating IA, is a β-1,3-glucan synthase inhibitor, which, when used in high concentrations, reverts the anticipated A. fumigatus growth inhibition, a phenomenon called the "caspofungin paradoxical effect" (CPE). The CPE has been widely associated with increased chitin content in the cell wall due to a compensatory upregulation of chitin synthase-encoding genes...
June 13, 2017: MBio
https://www.readbyqxmd.com/read/28579986/hiv-aspartic-peptidase-inhibitors-modulate-surface-molecules-and-enzyme-activities-involved-with-physiopathological-events-in-fonsecaea-pedrosoi
#14
Vanila F Palmeira, Daniela S Alviano, Lys A Braga-Silva, Fátima R V Goulart, Marcela Q Granato, Sonia Rozental, Celuta S Alviano, André L S Santos, Lucimar F Kneipp
Fonsecaea pedrosoi is the main etiological agent of chromoblastomycosis, a recalcitrant disease that is extremely difficult to treat. Therefore, new chemotherapeutics to combat this fungal infection are urgently needed. Although aspartic peptidase inhibitors (PIs) currently used in the treatment of human immunodeficiency virus (HIV) have shown anti-F. pedrosoi activity their exact mechanisms of action have not been elucidated. In the present study, we have investigated the effects of four HIV-PIs on crucial virulence attributes expressed by F...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28469160/differential-roles-for-six-p-type-calcium-atpases-in-sustaining-intracellular-ca-2-homeostasis-asexual-cycle-and-environmental-fitness-of-beauveria-bassiana
#15
Jie Wang, Xiao-Guan Zhu, Sheng-Hua Ying, Ming-Guang Feng
A global insight into the roles of multiple P-type calcium ATPase (CA) pumps in sustaining the life of a filamentous fungal pathogen is lacking. Here we elucidated the functions of five CA pumps (Eca1, Spf1 and PmcA/B/C) following previous characterization of Pmr1 in Beauveria bassiana, a fungal insect pathogen. The fungal CA pumps interacted at transcriptional level, at which singular deletions of five CA genes depressed eca1 expression by 76-98% and deletion of spf1 resulted in drastic upregulation of four CA genes by 36-50-fold...
May 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28250363/resistance-of-aspergillus-fumigatus-to-micafungin-is-increased-by-exogenous-%C3%AE-glucan
#16
Takashi Toyoshima, Ken-Ichi Ishibashi, Daisuke Yamanaka, Yoshiyuki Adachi, Naohito Ohno
Aspergillus species are ubiquitous in the environment and Aspergillus fumigatus can cause life-threatening infections in immunocompromised patients. β-1,3-/1,6-glucan is a major fungal cell wall polysaccharide that has various biological effects on the infected host, but little is known about the influence of β-glucan on the fungus itself. In a previous study, we demonstrated that the cell wall β-glucan content could be increased in Aspergillus spp. by addition of β-glucan to the culture medium. In this study, we investigated the influence of β-glucan on the susceptibility of A...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/28137806/preclinical-pharmacokinetics-and-pharmacodynamic-target-of-scy-078-a-first-in-class-orally-active-antifungal-glucan-synthesis-inhibitor-in-murine-models-of-disseminated-candidiasis
#17
Stephen A Wring, Ryan Randolph, SeongHee Park, George Abruzzo, Qing Chen, Amy Flattery, Graig Garrett, Michael Peel, Russell Outcalt, Kendall Powell, Michelle Trucksis, David Angulo, Katyna Borroto-Esoda
SCY-078 (MK-3118) is a novel, semisynthetic derivative of enfumafungin and represents the first compound of the triterpene class of antifungals. SCY-078 exhibits potent inhibition of β-(1,3)-d-glucan synthesis, an essential cell wall component of many pathogenic fungi, including Candida spp. and Aspergillus spp. SCY-078 is currently in phase 2 clinical development for the treatment of invasive fungal diseases. In vitro disposition studies to assess solubility, intestinal permeability, and metabolic stability were predictive of good oral bioavailability...
April 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28119468/candida-albicans-chitin-increases-arginase-1-activity-in-human-macrophages-with-an-impact-on-macrophage-antimicrobial-functions
#18
Jeanette Wagener, Donna M MacCallum, Gordon D Brown, Neil A R Gow
The opportunistic human fungal pathogen Candida albicans can cause a variety of diseases, ranging from superficial mucosal infections to life-threatening systemic infections. Phagocytic cells of the innate immune response, such as neutrophils and macrophages, are important first-line responders to an infection and generate reactive oxygen and nitrogen species as part of their protective antimicrobial response. During an infection, host cells generate nitric oxide through the enzyme inducible nitric oxide synthase (iNOS) to kill the invading pathogen...
January 24, 2017: MBio
https://www.readbyqxmd.com/read/28079053/molecular-evidence-for-the-involvement-of-a-polygalacturonase-inhibiting-protein-ghpgip1-in-enhanced-resistance-to-verticillium-and-fusarium-wilts-in-cotton
#19
Nana Liu, Xueyan Zhang, Yun Sun, Ping Wang, Xiancai Li, Yakun Pei, Fuguang Li, Yuxia Hou
Polygalacturonase-inhibiting protein (PGIP), belonging to a group of plant defence proteins, specifically inhibits endopolygalacturonases secreted by pathogens. Herein, we showed that purified GhPGIP1 is a functional inhibitor of Verticillium dahliae and Fusarium oxysporum f. sp. vasinfectum, the two fungal pathogens causing cotton wilt. Transcription of GhPGIP1 was increased in cotton upon infection, wounding, and treatment with defence hormone and H2O2. Resistance by GhPGIP1 was examined by its virus-induced gene silencing in cotton and overexpression in Arabidopsis...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28060864/a-major-facilitator-superfamily-transporter-mediated-resistance-to-oxidative-stress-and-fungicides-requires-yap1-skn7-and-map-kinases-in-the-citrus-fungal-pathogen-alternaria-alternata
#20
Li-Hung Chen, Hsieh-Chin Tsai, Pei-Ling Yu, Kuang-Ren Chung
Major Facilitator Superfamily (MFS) transporters play an important role in multidrug resistance in fungi. We report an AaMFS19 gene encoding a MFS transporter required for cellular resistance to oxidative stress and fungicides in the phytopathogenic fungus Alternaria alternata. AaMFS19, containing 12 transmembrane domains, displays activity toward a broad range of substrates. Fungal mutants lacking AaMFS19 display profound hypersensitivities to cumyl hydroperoxide, potassium superoxide, many singlet oxygen-generating compounds (eosin Y, rose Bengal, hematoporphyrin, methylene blue, and cercosporin), and the cell wall biosynthesis inhibitor, Congo red...
2017: PloS One
keyword
keyword
96807
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"