Hye-Min Jeon, Xun Jin, Joong-Seob Lee, Se-Yeong Oh, Young-Woo Sohn, Hyo-Jung Park, Kyeung Min Joo, Woong-Yang Park, Do-Hyun Nam, Ronald A DePinho, Lynda Chin, Hyunggee Kim
Cellular origins and genetic factors governing the genesis and maintenance of glioblastomas (GBM) are not well understood. Here, we report a pathogenetic role of the developmental regulator Id4 (inhibitor of differentiation 4) in GBM. In primary murine Ink4a/Arf(-/-) astrocytes, and human glioma cells, we provide evidence that enforced Id4 can drive malignant transformation by stimulating increased cyclin E to produce a hyperproliferative profile and by increased Jagged1 expression with Notch1 activation to drive astrocytes into a neural stem-like cell state...
August 1, 2008: Genes & Development