Manisha Dass, Mohinder Kaur, Simran Aittan, Pratibha Sharma, Sachin Punia, Rajagopalan Muthumohan, Divya Anthwal, Rakesh K Gupta, Gargi Mahajan, Pooja Kumari, Neera Sharma, Rajesh S Taneja, Lokesh K Sharma, Ritu Shree, Jaya S Tyagi, Vivek Lal, Sagarika Haldar
In view of WHO's "End-TB" strategy, we developed a non-invasive, urine-based ELISA, targeting 2 Mycobacterium tuberculosis antigens namely MPT51 and MPT64 for extrapulmonary TB (EPTB) diagnosis. Suspected EPTB patients (n = 137) [Pleural TB, Abdominal TB and Tuberculous meningitis] were categorized in "Definite" EPTB (n = 10) [Xpert-MTB/RIF and/or culture-positive], "Probable" EPTB (n = 77) and "Non-EPTB" (n = 50) groups using defined composite reference standards. ROC-curves were generated using ELISA results of "Definite" EPTB and "Non-EPTB" groups for both antigens independently and cut-off values were selected to provide 86...
May 5, 2023: Diagnostic Microbiology and Infectious Disease