keyword
https://read.qxmd.com/read/37291728/urinary-metabolite-profile-predicting-the-progression-of-chronic-kidney-disease
#21
JOURNAL ARTICLE
Yaerim Kim, Jueun Lee, Mi Sun Kang, Jeongin Song, Seong Geun Kim, Semin Cho, Hyuk Huh, Soojin Lee, Sehoon Park, Hyung Ah Jo, Seung Hee Yang, Jin Hyuk Paek, Woo Yeong Park, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Geum-Sook Hwang, Dong Ki Kim
BACKGROUND: Since chronic kidney disease (CKD) is caused by genetic and environmental factors, biomarker development through metabolomic analysis, which reflects gene-derived downstream effects and host adaptation to the environment, is warranted. METHODS: We measured the metabolites in urine samples collected from 789 patients at the time of kidney biopsy and from urine samples from 147 healthy subjects using nuclear magnetic resonance (NMR). The composite outcome was defined as a 30% decline in estimated glomerular filtration rate (eGFR), doubling of serum creatinine levels, or end-stage kidney disease...
June 9, 2023: Kidney360
https://read.qxmd.com/read/37271414/metabolomic-profile-of-the-healthy-eating-index-2015-in-the-multi-ethnic-study-of-atherosclerosis
#22
JOURNAL ARTICLE
Meghana D Gadgil, Alexis C Wood, Ibrahim Karaman, Goncalo Graça, Ioanna Tzoulaki, Victor W Zhong, Philip Greenland, Alka M Kanaya, David M Herrington
INTRODUCTION: Poor diet quality is a risk factor for type 2 diabetes and cardiovascular disease. However, knowledge of metabolites marking adherence to Dietary Guidelines for Americans (2015 version; DGA-15) are limited. The goal was to determine a pattern of metabolites associated with the Healthy Eating Index-2015 (HEI-2015), which measures adherence to the DGA. METHODS: The analysis examined 3557 adult men and women from the longitudinal cohort Multi-Ethnic Study of Atherosclerosis (MESA), without known cardiovascular disease and with complete dietary data...
June 2, 2023: Journal of Nutrition
https://read.qxmd.com/read/37224073/-corrigendum-to-betaine-ameliorates-high-glucose-induced-oxidative-stress-in-granulosa-cells
#23
JOURNAL ARTICLE
Mohammad Hussein Abnosi, Mohammad Reza Tabandeh, Fatmeh Mosavi-Aroo
CONTEXT: In diabetes, abnormalities of granulosa cells (GCs) and steroidogenesis are associated with hyperglycaemia-induced oxidative stress. Betaine has beneficial effect in experimental model of diabetes by reducing oxidative stress, inflammation, and apoptosis. AIMS: In this study we investigate the effects of betaine to prevent oxidative stress in GCs induced by high glucose and improve steroidogenesis. METHODS: Primary GCs, isolated from ovarian follicles of C57BL/6 mice were cultured in 5mM (control) and 30mM (hyperglycaemia) of glucose and in presence of 5mM of betaine for 24h...
May 2023: Reproduction, Fertility, and Development
https://read.qxmd.com/read/37203331/betaine-homocysteine-methyltransferase-promotes-adipocyte-commitment-and-insulin-resistance-via-p38-mapk-smad-signaling
#24
JOURNAL ARTICLE
Chuchu Liu, Yao Zhang, Yanping Wang, Ning Wang, Junting Xu, Xingxing Liang, Jie Xiong, Sijia Lu, Peihui Zhou, Junli Liu, Suzhen Chen
OBJECTIVE: Betaine-homocysteine methyltransferase (Bhmt) belongs to the family of methyltransferases and is involved in the one-carbon metabolic cycle, which is associated with the risk of diabetes and adiposity. This study aimed to explore whether Bhmt participated in the development of obesity or its associated diabetes, as well as the mechanism involved. METHODS: The expression levels of Bhmt were examined in stromal vascular fraction cells and mature adipocytes in obesity and nonobesity...
June 2023: Obesity
https://read.qxmd.com/read/37198607/healthy-nordic-diet-and-associations-with-plasma-concentrations-of-metabolites-in-the-choline-oxidation-pathway-a-cross-sectional-study-from-northern-sweden
#25
JOURNAL ARTICLE
André Hesselink, Anna Winkvist, Bernt Lindahl, Per M Ueland, Jörn Schneede, Ingegerd Johansson, Therese Karlsson
BACKGROUND: The choline oxidation pathway and metabolites involved have been linked to diseases including cardiovascular disease, type 2 diabetes and cancer. A healthy Nordic diet is a recently defined dietary pattern associated with decreased risk for these diseases. Our aim was to explore associations between adherence to a healthy Nordic diet and plasma concentrations of metabolites of the choline oxidation pathway. METHODS: The Healthy Nordic Food Index (HNFI) and Baltic Sea Diet Score (BSDS) were applied to cross-sectional data (n = 969) from the Västerbotten Intervention Programme in Northern Sweden to score adherence to a healthy Nordic diet...
May 17, 2023: Nutrition Journal
https://read.qxmd.com/read/37025407/distribution-characteristics-of-oral-microbiota-and-its-relationship-with-intestinal-microbiota-in-patients-with-type-2-diabetes-mellitus
#26
JOURNAL ARTICLE
Xiao-Jing Guo, Shi-Xuan Dai, Jin-di Lou, Xu-Xiang Ma, Xiao-Juan Hu, Li-Ping Tu, Ji Cui, Hao Lu, Tao Jiang, Jia-Tuo Xu
INTRODUCTION: Type 2 diabetes mellitus (T2DM) has a high incidence rate globally, increasing the burden of death, disability, and the economy worldwide. Previous studies have found that the compositions of oral and intestinal microbiota changed respectively in T2DM; whether the changes were associated or interacted between the two sites and whether there were some associations between T2DM and the ectopic colonization of oral microbiota in the gut still need to be identified. RESEARCH DESIGN AND METHODS: We performed a cross-sectional observational study; 183 diabetes and 74 controls were enrolled...
2023: Frontiers in Endocrinology
https://read.qxmd.com/read/36940486/betaine-ameliorates-high-glucose-induced-oxidative-stress-in-granulosa-cells
#27
JOURNAL ARTICLE
Mohammad Hussein Abnosi, Mohammad Reza Tabandeh, Fatmeh Mosavi-Aroo
CONTEXT: In diabetes, abnormalities of granulosa cells (GCs) and steroidogenesis are associated with hyperglycaemia-induced oxidative stress. Betaine has beneficial effect in experimental model of diabetes by reducing oxidative stress, inflammation, and apoptosis. AIMS: In this study we investigate the effects of betaine to prevent oxidative stress in GCs induced by high glucose and improve steroidogenesis. METHODS: Primary GCs, isolated from ovarian follicles of C57BL/6 mice were cultured in 5mM (control) and 30mM (hyperglycaemia) of glucose and in presence of 5mM of betaine for 24h...
March 2023: Reproduction, Fertility, and Development
https://read.qxmd.com/read/36874557/trimethylamine-n-oxide-and-related-metabolites-in-the-serum-and-risk-of-type-2-diabetes-in-the-chinese-population-a-case-control-study
#28
JOURNAL ARTICLE
Shenghong Qi, Lan Liu, Shulan He, Liqun Wang, Jiangping Li, Xian Sun
BACKGROUND: Trimethylamine N-oxide (TMAO) and its precursors have an association with type 2 diabetes mellitus (T2DM); however, the evidence is unclear. The current study examined the association of serial measures of serum TMAO and related metabolite concentrations with the risk of T2DM. METHODS: Our study was designed as a community case-control study with 300 participants (150 T2DM and 150 non-T2DM). We examined the association of serum concentrations of TMAO and its related metabolites [trimethylamine, choline, betaine, and L-carnitine] using UPLC-MS/MS...
2023: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/36809274/mapping-the-metabolic-reprogramming-induced-by-sodium-glucose-cotransporter-2-inhibition
#29
JOURNAL ARTICLE
Aviram Kogot-Levin, Yael Riahi, Ifat Abramovich, Ofri Mosenzon, Bella Agranovich, Liat Kadosh, Rachel Ben-Haroush Schyr, Doron Kleiman, Liad Hinden, Erol Cerasi, Danny Ben-Zvi, Ernesto Bernal-Mizrachi, Joseph Tam, Eyal Gottlieb, Gil Leibowitz
Diabetes is associated with increased risk for kidney disease, heart failure, and mortality. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) prevent these adverse outcomes; however, the mechanisms involved are not clear. We generated a roadmap of the metabolic alterations that occur in different organs in diabetes and in response to SGLT2i. In vivo metabolic labeling with 13C-glucose in normoglycemic and diabetic mice treated with or without dapagliflozin, followed by metabolomics and metabolic flux analyses, showed that, in diabetes, glycolysis and glucose oxidation are impaired in the kidney, liver, and heart...
April 10, 2023: JCI Insight
https://read.qxmd.com/read/36803209/a-generalized-covariate-adjusted-top-scoring-pair-algorithm-with-applications-to-diabetic-kidney-disease-stage-classification-in-the-chronic-renal-insufficiency-cohort-cric-study
#30
JOURNAL ARTICLE
Brian Kwan, Tobias Fuhrer, Daniel Montemayor, Jeffery C Fink, Jiang He, Chi-Yuan Hsu, Karen Messer, Robert G Nelson, Minya Pu, Ana C Ricardo, Hernan Rincon-Choles, Vallabh O Shah, Hongping Ye, Jing Zhang, Kumar Sharma, Loki Natarajan
BACKGROUND: The growing amount of high dimensional biomolecular data has spawned new statistical and computational models for risk prediction and disease classification. Yet, many of these methods do not yield biologically interpretable models, despite offering high classification accuracy. An exception, the top-scoring pair (TSP) algorithm derives parameter-free, biologically interpretable single pair decision rules that are accurate and robust in disease classification. However, standard TSP methods do not accommodate covariates that could heavily influence feature selection for the top-scoring pair...
February 20, 2023: BMC Bioinformatics
https://read.qxmd.com/read/36791500/hepatic-oleate-regulates-one-carbon-metabolism-during-high-carbohydrate-feeding
#31
JOURNAL ARTICLE
James M Ntambi, Xueqing Liu, Maggie S Burhans, Ahmed ALjohani, Ebru Selin Selen, Mugagga Kalyesubula, Fariba Assadi-Porter
Obesity is a major risk factor for type 2 diabetes, coronary heart disease, and strok. These diseases are associated with profound alterations in gene expression in metabolic tissues. Epigenetic-mediated regulation of gene expression is one mechanism through which environmental factors, such as diet, modify gene expression and disease predisposition. However, epigenetic control of gene expression in obesity and insulin resistance is not fully characterized. We discovered that liver-specific stearoyl-CoA desaturase-1 (Scd1) knockout mice (LKO) fed a high-carbohydrate low-fat diet exhibit dramatic changes in hepatic gene expression and metabolites of the folate cycle and one-carbon metabolism respectively for the synthesis of S-adenosylmethionine (SAM)...
April 9, 2023: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/36676988/comparative-insights-into-four-major-legume-sprouts-efficacies-for-diabetes-management-and-its-complications-untargeted-versus-targeted-nmr-biochemometrics-approach
#32
JOURNAL ARTICLE
Mohamed A Farag, Asmaa F Aboul Naser, Ahmed Zayed, Mohamed G Sharaf El-Dine
Interest in the consumption of seed sprouts is gradually increasing as functional foods in the modern Western diet owing to their several nutritional and health benefits. The present study aims to investigate four major legume sprouts derived from faba bean ( Vicia faba L.), lentil ( Lens esculenta L.), chickpea ( Cicer arietinum L.), and fenugreek ( Trigonella foenum-greacum L.) for their antidiabetic activity and mitigation of associated complications, i.e., oxidative stress, liver dysfunction, and lipid metabolism, compared with glibenclamide...
December 31, 2022: Metabolites
https://read.qxmd.com/read/36541189/crosslinked-zwitterionic-microcapsules-to-overcome-gastrointestinal-barriers-for-oral-insulin-delivery
#33
JOURNAL ARTICLE
Yuhong Ma, Qihang Li, Jingru Yang, Yuan Cheng, Caihua Li, Changshun Zhao, Wei Chen, Dechun Huang, Hongliang Qian
Oral insulin delivery has been extensively considered to achieve great patient compliance and convenience as well as favourable glucose homeostasis. However, its application is highly limited by the low insulin bioavailability owing to gastrointestinal barriers. Herein, we developed crosslinked zwitterionic microcapsules (CB-MCs@INS) based on a carboxyl betaine (CB)-modified poly(acryloyl carbonate- co -caprolactone) copolymer via the combination of microfluidics and UV-crosslinking to improve oral insulin delivery...
December 21, 2022: Biomaterials Science
https://read.qxmd.com/read/36474545/postprandial-metabolome-following-a-low-glycaemic-index-meal-challenge-test-a-narrative-review
#34
REVIEW
Zhi Ch'ng Lau, Barakatun Nisak Mohd Yusof, Faridah Abas, Norasyikin Abd Wahab, Wan Zul Haikal Wan Zukiman, Amin Ismail
The Identifying the dynamic metabolome of the individual in response to a particular stimulus using a metabolomic approach is an emerging research area. Measuring the postprandial metabolite response utilising a meal-challenge test (MCT) provides information beyond the fasting state, which is especially important since human beings spend most of their time in the postprandial state. This is pertinent as an excessive rise in postprandial glycaemia is common in individuals with type 2 diabetes mellitus (T2DM), which puts them at a high risk of developing cardiovascular disease (CVD)...
October 2022: Malaysian Journal of Medical Sciences: MJMS
https://read.qxmd.com/read/36235580/high-folate-perturbed-one-carbon-metabolism-and-gestational-diabetes-mellitus
#35
REVIEW
Jessica M Williamson, Anya L Arthurs, Melanie D Smith, Claire T Roberts, Tanja Jankovic-Karasoulos
Folate is a dietary micronutrient essential to one-carbon metabolism. The World Health Organisation recommends folic acid (FA) supplementation pre-conception and in early pregnancy to reduce the risk of fetal neural tube defects (NTDs). Subsequently, many countries (~92) have mandatory FA fortification policies, as well as recommendations for periconceptional FA supplementation. Mandatory fortification initiatives have been largely successful in reducing the incidence of NTDs. However, humans have limited capacity to incorporate FA into the one-carbon metabolic pathway, resulting in the increasingly ubiquitous presence of circulating unmetabolised folic acid (uFA)...
September 22, 2022: Nutrients
https://read.qxmd.com/read/36220981/association-between-methyl-donor-nutrients-and-metabolic-health-status-in-overweight-and-obese-adolescents
#36
JOURNAL ARTICLE
Donya Poursalehi, Keyhan Lotfi, Saeideh Mirzaei, Ali Asadi, Masoumeh Akhlaghi, Parvane Saneei
Limited evidence is available regarding the association of methyl donor nutrients and adolescents' metabolic health. Therefore, we investigated the relation between a combination of methyl donor nutrients and metabolic health status of overweight and obese Iranian adolescents. In this cross-sectional study, 203 overweight/obese adolescents were included, using a multistage cluster random-sampling method. Dietary intakes were assessed by a validated food frequency questionnaire. Methyl donor nutrient score (MDNS) was constructed based on deciles of vitamins B2, B6, B9, B12, methionine, choline and betaine...
October 11, 2022: Scientific Reports
https://read.qxmd.com/read/36183068/interactions-of-cdkal1-rs7747752-polymorphism-and-serum-levels-of-l-carnitine-and-choline-are-related-to-increased-risk-of-gestational-diabetes-mellitus
#37
JOURNAL ARTICLE
Hui Wang, Jing Li, Jinnan Liu, Junhong Leng, Weiqin Li, Zhijie Yu, Claudia H T Tam, Gang Hu, Ronald C W Ma, Zhongze Fang, Ying Wang, Xilin Yang
BACKGROUND: Interactions between genetic, metabolic, and environmental factors lead to gestational diabetes mellitus (GDM). We aimed to examine interactive effects of cyclin-dependent kinase 5 regulatory subunit-associated protein1-like 1(CDKAL1) rs7747752 polymorphism with low serum levels of L-carnitine, choline, and betaine for GDM. METHODS: A nested case-control study of 207 GDM women and their one-to-one, age-matched controls was organized from a prospective cohort of pregnant women in Tianjin, China...
October 1, 2022: Genes & Nutrition
https://read.qxmd.com/read/36087182/betaine-protects-against-sodium-arsenite-induced-diabetes-and-hepatotoxicity-in-mice
#38
JOURNAL ARTICLE
Parian Pourmoafi Esfahani, Masoud Mahdavinia, Layasadat Khorsandi, Mohsen Rezaei, Hojatolla Nikravesh, Mohammad Javad Khodayar
Epidemiological evidence has associated chronic exposure to inorganic arsenic with an increased occurrence of glucose intolerance and diabetes mellitus. Furthermore, inorganic arsenic induces oxidative stress in organs such as the liver. Betaine, as a methyl donor, plays a pivotal role in homocysteine metabolism. Betaine has antioxidant and anti-inflammatory properties. Therefore, the aim of this study was to evaluate the effects of betaine against sodium arsenite-induced diabetes and hepatotoxicity in mice...
September 10, 2022: Environmental Science and Pollution Research International
https://read.qxmd.com/read/36060961/distinct-impacts-of-fat-and-fructose-on-the-liver-muscle-and-adipose-tissue-metabolome-an-integrated-view
#39
JOURNAL ARTICLE
Maria João Meneses, Inês Sousa-Lima, Ivana Jarak, João F Raposo, Marco G Alves, Maria Paula Macedo
OBJECTIVE: In the last years, changes in dietary habits have contributed to the increasing prevalence of metabolic disorders, such as non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM). The differential burden of lipids and fructose on distinct organs needs to be unveiled. Herein, we hypothesized that high-fat and high-fructose diets differentially affect the metabolome of insulin-sensitive organs such as the liver, muscle, and different adipose tissue depots...
2022: Frontiers in Endocrinology
https://read.qxmd.com/read/36014850/impaired-amino-acid-metabolism-and-its-correlation-with-diabetic-kidney-disease-progression-in-type-2-diabetes-mellitus
#40
JOURNAL ARTICLE
Huanhuan Zhu, Mengqiu Bai, Xishao Xie, Junni Wang, Chunhua Weng, Huifen Dai, Jianghua Chen, Fei Han, Weiqiang Lin
BACKGROUND: Metabolomics is useful in elucidating the progression of diabetes; however, the follow-up changes in metabolomics among health, diabetes mellitus, and diabetic kidney disease (DKD) have not been reported. This study was aimed to reveal metabolomic signatures in diabetes development and progression. METHODS: In this cross-sectional study, we compared healthy (n = 30), type 2 diabetes mellitus (T2DM) (n = 30), and DKD (n = 30) subjects with the goal of identifying gradual altering metabolites...
August 15, 2022: Nutrients
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