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Intravascular ultrasound and carotid artery and atherosclerosis

Alexander Maier, Patricia Plaza-Heck, Fabian Meixner, Felix Guenther, Beat A Kaufmann, Mara Kramer, Timo Heidt, Andreas Zirlik, Ingo Hilgendorf, Jochen Reinöhl, Peter Stachon, Peter Bronsert, Ralf Birkemeyer, Irene Neudorfer, Karlheinz Peter, Christoph Bode, Constantin von Zur Mühlen
BACKGROUND AND AIMS: Activated platelets are amongst the most attractive imaging targets in atherosclerosis due to their important role in early processes of atherogenesis and thrombus formation. We developed a molecular intravascular ultrasound (IVUS) approach to detect activated platelets ex vivo on the surface of human plaques, using an IVUS system applied in clinical routine. METHODS: Human carotid endarterectomy specimens were obtained directly from the operating room and exposed to artificial arterial flow conditions for incubation with the contrast agent...
December 2017: Atherosclerosis
Oliver Faust, U Rajendra Acharya, Vidya K Sudarshan, Ru San Tan, Chai Hong Yeong, Filippo Molinari, Kwan Hoong Ng
The diagnosis of Coronary Artery Disease (CAD), Myocardial Infarction (MI) and carotid atherosclerosis is of paramount importance, as these cardiovascular diseases may cause medical complications and large number of death. Ultrasound (US) is a widely used imaging modality, as it captures moving images and image features correlate well with results obtained from other imaging methods. Furthermore, US does not use ionizing radiation and it is economical when compared to other imaging modalities. However, reading US images takes time and the relationship between image and tissue composition is complex...
January 2017: Physica Medica: PM
Johan W Verjans, Eric A Osborn, Giovanni J Ughi, Marcella A Calfon Press, Ehsan Hamidi, Antonios P Antoniadis, Michail I Papafaklis, Mark F Conrad, Peter Libby, Peter H Stone, Richard P Cambria, Guillermo J Tearney, Farouc A Jaffer
OBJECTIVES: This study sought to determine whether indocyanine green (ICG)-enhanced near-infrared fluorescence (NIRF) imaging can illuminate high-risk histologic plaque features of human carotid atherosclerosis, and in coronary atheroma of living swine, using intravascular NIRF-optical coherence tomography (OCT) imaging. BACKGROUND: New translatable imaging approaches are needed to identify high-risk biological signatures of atheroma. ICG is a U.S. Food and Drug Administration-approved NIRF imaging agent that experimentally targets plaque macrophages and lipid in areas of enhanced endothelial permeability...
September 2016: JACC. Cardiovascular Imaging
Jung-Sun Kim, Sungha Park, Ping Yan, Barrett W Jeffers, César Cerezo
Aims: To investigate the relationship between visit-to-visit blood pressure variability (BPV) and the progression of both carotid and coronary artery disease (CAD). Methods and results: Data from two cardiovascular endpoint studies [Norvasc for Regression of Manifest Atherosclerotic Lesions by Intravascular Sonographic Evaluation (NORMALISE) and Prospective Randomized Evaluation of the Vascular Effects of Norvasc Trial (PREVENT)] were analysed separately. Systolic BPV was assessed as within-subject standard deviation of systolic BP across visits from 12-weeks onwards...
April 1, 2017: European Heart Journal. Cardiovascular Pharmacotherapy
Tadashi Araki, Nobutaka Ikeda, Devarshi Shukla, Narendra D Londhe, Vimal K Shrivastava, Sumit K Banchhor, Luca Saba, Andrew Nicolaides, Shoaib Shafique, John R Laird, Jasjit S Suri
Interventional cardiologists have a deep interest in risk stratification prior to stenting and percutaneous coronary intervention (PCI) procedures. Intravascular ultrasound (IVUS) is most commonly adapted for screening, but current tools lack the ability for risk stratification based on grayscale plaque morphology. Our hypothesis is based on the genetic makeup of the atherosclerosis disease, that there is evidence of a link between coronary atherosclerosis disease and carotid plaque built up. This novel idea is explored in this study for coronary risk assessment and its classification of patients between high risk and low risk...
February 2016: Computer Methods and Programs in Biomedicine
Adelina Curaj, Zhuojun Wu, Stanley Fokong, Elisa A Liehn, Christian Weber, Alexandrina Burlacu, Twan Lammers, Marc van Zandvoort, Fabian Kiessling
OBJECTIVE: Cardiovascular interventions induce damage to the vessel wall making antithrombotic therapy inevitable until complete endothelial recovery. Without a method to accurately determine the endothelial status, many patients undergo prolonged anticoagulation therapy, denying them any invasive medical procedures, such as surgical operations and dental interventions. Therefore, we aim to introduce molecular ultrasound imaging of the vascular cell adhesion molecule (VCAM)-1 using targeted poly-n-butylcyanoacrylate microbubbles (MB(VCAM-1)) as an easy accessible method to monitor accurately the reendothelialization of vessels...
June 2015: Arteriosclerosis, Thrombosis, and Vascular Biology
T Araki, N Ikeda, F Molinari, N Dey, S Acharjee, L Saba, J S Suri
AIM: Establishing relationship between coronary calcium volumes from Intravascular Ultrasound (IVUS) and automated carotid intima-media thickness (cIMT) helps in understanding the genetic nature of atherosclerosis disease. In this research, we have quantified the detected calcium from IVUS video frames and associated a relationship between coronary calcium volumes computed and automated cIMT from B-mode ultrasound. METHODS: Coronary calcium volume is computed from IVUS and auto cIMTs are computed using B-mode ultrasound...
August 2014: International Angiology: a Journal of the International Union of Angiology
Ani Manichaikul, Stephen S Rich, Heather Perry, Joseph Yeboah, Michelle Law, Molly Davis, Matthew Parker, Michael Ragosta, Jessica J Connelly, Coleen A McNamara, Angela M Taylor
AIMS: We previously identified association between the ID3 SNP rs11574 and carotid intima-media thickness in the Diabetes Heart Study, a predominantly White diabetic population. The nonsynonymous SNP rs11574 results in an amino acid substitution in the C-terminal region of ID3, attenuating the dominant negative function of ID3 as an inhibitor of basic HLH factor E12-mediated transcription. In the current investigation, we characterize the association between the functionally significant polymorphism in ID3, rs11574, with human coronary pathology...
2014: PloS One
Younes Majdouline, Jacques Ohayon, Zahra Keshavarz-Motamed, Marie-Hélène Roy Cardinal, Damien Garcia, Louise Allard, Sophie Lerouge, Frédéric Arsenault, Gilles Soulez, Guy Cloutier
This work explores the potential of shear strain elastograms to identify vulnerable atherosclerotic plaques. The Lagrangian speckle model estimator (LSME) elasticity imaging method was further developed to estimate shear strain elasticity (SSE). Three polyvinyl alcohol cryogel vessel phantoms were imaged with an intravascular ultrasound (IVUS) scanner. The estimated SSE maps were validated against finite-element results. Atherosclerosis was induced in carotid arteries of eight Sinclair mini-pigs using a combination of surgical techniques, diabetes and a high-fat diet...
May 2014: Ultrasound in Medicine & Biology
Konstantinos Toutouzas, Andreas Synetos, Charalampia Nikolaou, Konstantinos Stathogiannis, Eleftherios Tsiamis, Christodoulos Stefanadis
Atherosclerosis and its consequences are the most rapidly growing vascular pathology, with myocardial infarction and ischemic cerebrovascular accident to remain a major cause of premature morbidity and death. In order to detect the morphological and functional characteristics of the vulnerable plaques, new imaging modalities have been developed. Intravascular thermography (IVT) is an invasive method, which provides information on the identification of the high-risk atheromatic plaques in coronary arteries. However, the invasive character of IVT excludes the method from primary prevention...
December 2012: Cardiovascular Diagnosis and Therapy
Wojciech Witkiewicz, Piotr Klimeczek, Wojciech Iwanowski, Bernadetta Pasicka, Bartosz Dołega-Kozierowski, Stanisław Drelichowski, Krzysztof Dyś, Urszula Zaleska-Dorobisz
One of the most common causes of stroke is carotid atherosclerosis, stroke affects about 60 thousand Polish people each year and about 27% of them die within a year. About 72%-86% are ischemic strokes, whereas intracerebral or subarachnoid haemorrhages account for about 9-18% of strokes. Stroke is the third most common cause of death worldwide, after heart disease and cancer, and the most often cause of chronic disability in people over 40. Carotid atherosclerosis is one of the most important stroke risk factors...
2013: Przegla̧d Lekarski
T Kovarnik, A Kral, H Skalicka, L Skalicka, O Dostal, L Kralik, P Martasek, M Aschermann, J Horak, A Linhart, A Wahle, M Sonka
The prediction of coronary vessel involvement by means of noninvasive tests is one of the fundamental objectives of preventive cardiology. This review describes the current possibilities of coronary vessel involvement prediction by means of ultrasonographic examination of carotid arteries, analysis of polymorphisms in the genes encoding enzymes responsible for production of nitric oxide and carbon monoxide and assessment of levels of certain proinflammatory cytokines. In the presented work these noninvasive markers are correlated with the extent of coronary vessel involvement as assessed by coronary angiography, intravascular ultrasound and virtual histology (Fig...
2013: Bratislavské Lekárske Listy
Tomas Kovarnik, Ales Kral, Hana Skalicka, Gary S Mintz, Lubomir Kralik, Martin Chval, Jan Horak, Lenka Skalicka, Milan Sonka, Andreas Wahle, Richard W Downe, Jana Uhrova, Hana Benakova, Lenka Cernohousova, Pavel Martasek, Jan Belohlavek, Michael Aschermann, Ales Linhart
OBJECTIVE: Prediction of coronary atherosclerosis in patients with stable angina based on non-invasive examinations. METHODS: Pro-inflammatory markers, heme oxygenase-1 (HO-1) polymorphism, lipid levels, Framingham risk score (FRS), and carotid ultrasound were analyzed and compared to grayscale and virtual histology intravascular ultrasound (VH-IVUS). RESULTS: A total of 101 patients were included, and genetic analysis was performed on 81 patients (80...
January 2013: Journal of Invasive Cardiology
Gilles Soulez, Sophie Lerouge, Louise Allard, Philippe Roméo, Shijie Qi, Hélène Héon, Jean-Claude Tardif, Guy Cloutier
PURPOSE: To compare the creation of carotid atherosclerotic plaque after stenosis creation with absorbable or permanent suture in a diabetic dyslipidemic swine model. MATERIALS AND METHODS: A high-cholesterol diet was fed to 15 Sinclair pigs. Diabetes was induced by intraarterial injection of streptozotocin. Stenosis creation in carotid arteries was performed with an absorbable or a permanent suture assigned randomly on both sides. After 20 weeks, Doppler ultrasound (US), angiography, and intravascular US examinations were performed before sacrifice...
December 2012: Journal of Vascular and Interventional Radiology: JVIR
Jinwei Tian, Sining Hu, Yanli Sun, Huai Yu, Xue Han, Wen Cheng, Xiang Ban, Shaosong Zhang, Bo Yu, Ik-Kyung Jang
OBJECTIVES: To serially investigate the relationship between vasa vasorum (VV) proliferation and plaque progression in vivo, and the effects of atorvastatin on VV and atherosclerosis as assessed by contrast-enhanced ultrasound (CEUS) and intravascular ultrasound (IVUS) imaging. METHODS: Carotid atherosclerosis was induced in rabbits with a high-cholesterol diet for 20 weeks and balloon injury. At week 16, following the imaging of the right common carotid arteries by CEUS and IVUS, 20 rabbits were randomised into a control or atorvastatin group (2 mg/kg/day)...
January 2013: Heart: Official Journal of the British Cardiac Society
Antti Kivelä, Juha Hartikainen, Seppo Ylä-Herttuala
BACKGROUND: Neointimal formation in atherosclerosis has been subject for intense research. However, good animal models mimicking asymmetrical lesion formation in human subjects have been difficult to establish. The aim of this study was to develop a model which would lead to the formation of eccentric lesions under macroscopically intact non-denuded endothelium. METHODS: We have developed a new collar model where we placed two cushions or dots inside the collar...
October 17, 2012: BMC Cardiovascular Disorders
Chris L de Korte, Hendrik H G Hansen, Anton F W van der Steen
Cardiovascular disease is a leading cause of death in the Western world. Therefore, detection and quantification of atherosclerotic disease is of paramount importance to monitor treatment and possible prevention of acute events. Vascular ultrasound is an excellent technique to assess the geometry of vessel walls and plaques. The high temporal as well as spatial resolution allows quantification of luminal area and plaque size and volume. While carotid arteries can be imaged non-invasively, scanning of coronary arteries requires invasive intravascular catheters...
August 6, 2011: Interface Focus
Satheesh Balakrishnan Nair, Rayaz Malik, Rajdeep S Khattar
Ultrasound measurement of carotid intima-media thickness (IMT) has become a valuable tool for detecting and monitoring progression of atherosclerosis and recently published recommendations provide guidance for proper standardisation of these measurements. Important determinants of carotid IMT include age, gender, systolic blood pressure, diabetes mellitus and serum cholesterol levels. Many studies have shown carotid IMT to correlate with the severity of coronary atherosclerosis assessed by CT coronary calcification scores, coronary angiography and intravascular ultrasound...
December 2012: Postgraduate Medical Journal
Yoshiki Matsuo, Takuro Takumi, Verghese Mathew, Woo-Young Chung, Gregory W Barsness, Charanjit S Rihal, Rajiv Gulati, Eric T McCue, David R Holmes, Eric Eeckhout, Ryan J Lennon, Lilach O Lerman, Amir Lerman
BACKGROUND: Few studies have examined plaque characteristics among multiple arterial beds in vivo. The purpose of this study was to compare the plaque morphology and arterial remodeling between coronary and peripheral arteries using gray-scale and radiofrequency intravascular ultrasound (IVUS) at clinical presentation. METHODS AND RESULTS: IVUS imaging was performed in 68 patients with coronary and 93 with peripheral artery lesions (29 carotid, 50 renal, and 14 iliac arteries)...
August 2012: Atherosclerosis
Jinwei Tian, Sining Hu, Yanli Sun, Xiang Ban, Huai Yu, Nana Dong, Jian Wu, Bo Yu
This study aim was to develop a new model of atherosclerosis by FeCl(3)-induced injury to right common carotid arteries (CCAs) of rabbits. Right CCAs were induced in male New Zealand White rabbits (n = 15) by combination of a cholesterol-rich diet and FeCl(3)-induced injury to arterial walls. The right and left CCAs were evaluated by histology and in vivo intravascular ultrasound (IVUS) and optical coherence tomography (OCT) examinations of 24 hours (n = 3), 8 weeks (n = 6), and 12 weeks (n = 6) after injury...
2012: Journal of Biomedicine & Biotechnology
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