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https://www.readbyqxmd.com/read/29349807/possible-role-of-plasmacytoid-dendritic-cells-in-pityriasis-lichenoides
#1
M Karouni, J Abou Rahal, M Kurban, A G Kibbi, O Abbas
BACKGROUND: Plasmacytoid dendritic cells (pDCs) and their product, type I interferons (IFNs), have been implicated in the pathogenesis of several skin disorders characterized by an interface dermatitis (ID) pattern, such as lichen planus (LP). A type I IFN signature has previously been documented in pityriasis lichenoides (PL). Although pDCs are known to be the main source and most potent producers of local type I IFNs, their role in PL has not been investigated. AIM: To investigate the role of pDCs in PL...
January 19, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29335741/methotrexate-treatment-for-pityriasis-rubra-pilaris-a-case-series-and-literature-review
#2
Lukas Koch, Clemens Schöffl, Werner Aberer, Cesare Massone
Treatment recommendations for pityriasis rubra pilaris (PRP) are based solely on case reports and small case series, as to-date no randomized controlled trials are available. We present here a case series of 3 patients and a literature review of 28 studies treating a total of 116 patients, with the aim of providing data regarding efficacy and safety of methotrexate in the treatment of PRP. Methotrexate was effective in our patients; the review showed an overall response rate of 65.5% with complete clearing in 23...
January 16, 2018: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29315771/pityriasis-lichenoides-long-term-follow-up-study
#3
Julie B Zang, Sarah J Coates, Jing Huang, Eric C Vonderheid, Bernard A Cohen
BACKGROUND/OBJECTIVES: Pityriasis lichenoides is an uncommon papulosquamous disorder of unknown etiology. The objective of this study was to review the clinical features and treatment responses of individuals with pityriasis lichenoides seen at a tertiary referral center. METHODS: Seventy-five patients diagnosed with pityriasis lichenoides between 1997 and 2013 were reviewed, and 46 had long-term follow-up via telephone interviews. RESULTS: Fifty (67%) patients were diagnosed with pityriasis lichenoides chronica, 22 (29%) with pityriasis lichenoides et varioliformis acuta, and 3 (4%) with mixed pityriasis lichenoides chronica and pityriasis lichenoides et varioliformis acuta features...
January 9, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29310979/malassezia-species-in-students-from-universities-of-sabzevar-northeastern-iran
#4
H Moallaei, M J Namazi, J P Bouchara, S Pourhammed
BACKGROUND: Malassezia species, usually part of normal human skin microbiota, may also cause cutaneous infections, mainly pityriasis versicolor (PV) which may rapidly spread in crowded communities, particularly in students' dormitories and sport leisure centers. OBJECTIVE: Few studies have been conducted on PV in students in the Middle East. The present study was designed to determine prevalence of Malassezia species and related diseases in students from city of Sabzevar, Northeast Iran...
January 5, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29302927/a-review-on-pityriasis-rubra-pilaris
#5
REVIEW
Dingyuan Wang, Vanessa Cui-Lian Chong, Wei-Sheng Chong, Hazel H Oon
Pityriasis rubra pilaris (PRP) is an idiopathic, papulosquamous inflammatory dermatosis. It is characterized by hyperkeratotic follicular papules coalescing into orange-red scaly plaques, islands of sparing, and palmoplantar keratoderma. PRP can be subdivided into six clinical subtypes according to Griffiths' classification, based on age of onset, disease extent, prognosis, and other associated features. The sixth subtype of PRP occurs in individuals affected by HIV infection, and retroviral screening in all de novo cases of PRP is advised...
January 4, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29301808/skin-and-coeliac-disease-a-lot-to-think-about-a-case-series
#6
Sara O Vaz, Catarina Franco, Patrícia Santos, Raquel Amaral
Coeliac disease (CD) is an autoimmune disease, characterised by a permanent sensitivity to gluten. It is being progressively recognised as a multisystemic disease, with multiple extraintestinal manifestations. Skin conditions (eg, dermatitis herpetiformis) are an example of its manifestations; however, its underlying mechanisms are still not well understood. This article presents three cases of uncommon skin conditions in patients with a history of CD. Two of them concern linear IgA bullous dermatosis and erythema nodosum, which have been described in the literature as having potential associations with CD, though only a few cases were reported...
January 4, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29290415/-pityriasis-rubra-pilaris
#7
S Quenan, E Laffitte
Pityriasis rubra pilaris is a rare heterogeneous dermatosis associating three clinical signs to different degrees: follicular corneal papules, reddish-orange palmoplantar keratoderma and erythematosquamous lesions that may in some cases be very extensive, interspersed with patches of healthy skin. The aetiology is unclear, and in most cases, the trigger factors consist of trauma or infection, probably in subjects with an existing predisposition. In other cases, the condition is associated with immunological disorders or, in familial cases, genetic keratinisation abnormalities similar to ichthyosis...
December 28, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29276879/unilateral-pityriasis-rosea-in-a-child-a-rare-clinical-presentation
#8
Atiye Oğrum
Oğrum A. Unilateral pityriasis rosea in a child: A rare clinical presentation. Turk J Pediatr 2017; 59: 214-216. Pityriasis rosea is a common papulosquamous disorder with occasional variations in lesion morphology, distribution, number and course of disease. The lesions are classically arranged with their long axes parallel to the Langer`s lines of cleavage and typically affect the trunk and the proximal extremities. Variations in the distribution of pityriasis rosea include inversus, localized, and unilateral forms...
2017: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/29260902/correction-to-el-housiny-et%C3%A2-al-fluconazole-loaded-solid-lipid-nanoparticles-topical-gel-for-treatment-of-pityriasis-versicolor-formulation-and-clinical-study
#9
(no author information available yet)
No abstract text is available yet for this article.
December 20, 2017: Drug Delivery
https://www.readbyqxmd.com/read/29249261/atrophying-pityriasis-versicolor
#10
F Allegue, C Fachal, D González-Vilas, A Zulaica
No abstract text is available yet for this article.
December 14, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29247481/pityriasis-rubra-pilaris-algorithms-for-diagnosis-and-treatment
#11
REVIEW
S Roenneberg, T Biedermann
Pityriasis rubra pilaris (PRP) is a rare inflammatory skin disease that affects men and women of all ages and also children. The clinical appearance of PRP is highly variable, as is the individual prognosis. Therefore, stratifying PRP into six disease subtypes represents a first step to personalized medicine for this rare inflammatory skin disease. The next step should be to associate specific therapeutic strategies with these subtypes of PRP. However, no randomized, controlled trials on the treatment of PRP have been performed...
December 15, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29240866/pityriasis-folliculorum-response-to-topical-ivermectin
#12
Kavita Darji, Nicole M Burkemper
<p>Pityriasis folliculorum has been described as a dry type of rosacea with extensive proliferation of Demodex folliculorum in pilosebaceous follicles of the skin. This skin condition is frequently difficult to manage, with various treatment options showing mixed efficacy. Oral ivermectin, a macrocyclic lactone parasiticide with anti-inflammatory and anti-parasitic effects, is one of the leading treatment modalities for demodicosis. Topical ivermectin has recently been FDA approved as therapy for rosacea...
December 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29239242/fluconazole-loaded-solid-lipid-nanoparticles-topical-gel-for-treatment-of-pityriasis-versicolor-formulation-and-clinical-study
#13
Shaimaa El-Housiny, Maii Atef Shams Eldeen, Yasmina Ahmed El-Attar, Hoda A Salem, Dalia Attia, Ehab R Bendas, Mohamed A El-Nabarawi
Solid lipid nanoparticles (SLNs) are very potential formulations for topical delivery of antifungal drugs. Hence, the purpose of this research was to formulate the well-known antifungal agent Fluconazole (FLZ)-loaded SLNs topical gel to improve its efficiency for treatment of Pityriasis Versicolor (PV). FLZ-SLNs were prepared by modified high shear homogenization and ultrasonication method using different concentration of solid lipid (Compritol 888 ATO, Precirol ATO5) and surfactant (Cremophor RH40, Poloxamer 407)...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29222811/association-of-hla-dqb1-03-03-with-pityriasis-rosea-in-chinese-patients
#14
L-Y Fu, C-C Xu, X-D Zheng, G Chen, J Zhu, P-G Wang
BACKGROUND: The association of human leucocyte antigen (HLA) with a variety of diseases has been described, especially with various autoimmune diseases. However, there are few studies on the association between HLA and pityriasis rosea (PR). AIM: To investigate the relevance of HLA II alleles with the development of PR. METHODS: Typing for HLA-DRB1, HLA-DQA1 and HLA-DQB1 typing was performed in 55 patients with PR and 90 healthy controls (HCs), using sequence-based typing (SBT) and PCR with sequence-specific primers (PCR-SSP), respectively...
December 8, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29221609/pitiryasis-lichenoides-et-varioliformis-aacuta-associated-with-human-herpesvirus-7
#15
M Costa-Silva, A Calistru, J Sobrinho-Simões, C Lisboa, F Azevedo
Pityriasis lichenoides et varioliformis acuta and pityriasis lichenoides chronica represent 2 ends of a disease spectrum of unknown etiology. Herein we describe 2 cases of pityriasis lichenoides et varioliformis acuta, in which human herpesvirus 7 DNA was detected in skin samples by polymerase chain reaction methodology, an association not previously described. This report may support the involvement of viral infection in the etiopathogeny of this disease.
December 5, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29213272/host-responses-to-malassezia-spp-in-the-mammalian-skin
#16
REVIEW
Florian Sparber, Salomé LeibundGut-Landmann
The skin of mammalian organisms is home for a myriad of microbes. Many of these commensals are thought to have beneficial effects on the host by critically contributing to immune homeostasis. Consequently, dysbiosis can have detrimental effects for the host that may manifest with inflammatory diseases at the barrier tissue. Besides bacteria, fungi make an important contribution to the microbiota and among these, the yeast Malassezia widely dominates in most areas of the skin in healthy individuals. There is accumulating evidence that Malassezia spp...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29210716/relationship-between-pityriasis-lichenoides-and-mycosis-fungoides-a-clinicopathological-immunohistochemical-and-molecular-study
#17
Hiba Zaaroura, Dvora Sahar, Tova Bick, Reuven Bergman
BACKGROUND: Several cases of pityriasis lichenoides (PL) have been reported to evolve into mycosis fungoides (MF). OBJECTIVE: To elucidate clues to this progression. METHODS: Fifty-eight patients with PL between 2000 and 2013 (follow-up: 3-16 years, average: 8.3). RESULTS: A total of 3 (5.2%) of the 58 patients with PL developed MF after 3-11 years of prolonged clinical course. Papules and small plaques characterized PLs, and patches and larger plaques subsequent MFs...
November 22, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29198426/luliconazole-a-new-antifungal-against-candida-species-isolated-from-different-sources
#18
S Taghipour, N Kiasat, S Shafiei, M Halvaeezadeh, A Rezaei-Matehkolaei, A Zarei Mahmoudabadi
OBJECTIVE: Luliconazole is an inhibitor for sterol 14-α-demethylase in fungal cells with a broad-spectrum antifungal activity against dermatophytes, Candida albicans, Malassezia species, dematiaceous and hyaline hyphomycetes. Furthermore, luliconazole has been clinically used for the treatment of pityriasis versicolor, dermatophytosis, onychomycosis, cutaneous and mucocutaneous candidiasis. In the present study, we aimed to evaluate in vitro antifungal activity of luliconazole against several strains of Candida species recovered from different clinical materials...
November 29, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29184428/management-of-refractory-pityriasis-rubra-pilaris-challenges-and-solutions
#19
REVIEW
Gaia Moretta, Erika V De Luca, Alessandro Di Stefani
Pityriasis rubra pilaris (PRP) is a rare chronic inflammatory papulosquamous skin disease. Its clinical presentation and evolution is very variable. The most frequent clinical features are follicular papules, progressing to yellow-orange erythroderma with round small areas of normal skin and the well-demarcated palmoplantar keratoderma. Actually, six different types of PRP have been described based on clinical characteristics, age of onset, and prognosis. The pathogenesis is still unknown, and treatment can be challenging...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29182459/recurrent-pityriasis-rosea-a-case-report
#20
Ang Li, Ping Li, Yanqiong Li, Wenfei Li
Pityriasis rosea is a papulosquamous skin disorder that occurs most commonly between the ages of 10 and 35 years. Recurrent pityriasis rosea is rare. We report a patient suffering from recurrent pityriasis rosea, whose etiology may be related to either vaccine-induced stimulation of the immune system, or some rare vaccine component(influenza A [H1N1] vaccine, hepatitis B vaccine). We believe that such a case is unique and it has not been reported previously. The patient was successfully treated with a combination of oral cetirizine, a topical steroid cream, and narrowband-ultraviolet B phototherapy...
November 28, 2017: Human Vaccines & Immunotherapeutics
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