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https://www.readbyqxmd.com/read/27896859/paraneoplastic-pityriasis-rubra-pilaris-case-report-and-literature-review
#1
E Bar-Ilan, A Gat, E Sprecher, T Zeeli
Pityriasis rubra pilaris (PRP; MIM 173200) is an uncommon papulosquamous inflammatory dermatosis. Only a few cases of PRP associated with an underlying malignancy have been documented. We investigated a 59-year-old patient presenting with a fulminant form of PRP recalcitrant to systemic retinoid therapy, in whom the skin disease heralded a diagnosis of cholangiocarcinoma. We searched the MEDLINE database to find articles reporting on similar associations of PRP with malignancies. We identified 10 studies linking PRP and malignancies, but an association between PRP and cholangiocarcinoma has not yet been reported...
November 29, 2016: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27885419/ketoconazole-inhibits-malassezia-furfur-morphogenesis-in-vitro-under-filamentation-optimized-conditions
#2
Sirida Youngchim, Joshua D Nosanchuk, Siriporn Chongkae, Nongnuch Vanittanokom
Malassezia furfur, a constituent of the normal human skin flora, is an etiological agent of pityriasis versicolor, which represents one of the most common human skin diseases. Under certain conditions, both exogenous and endogenous, the fungus can transition from a yeast form to a pathogenic mycelial form. To develop a standardized medium for reproducible production of the mycelial form of M. furfur to develop and optimize susceptibility testing for this pathogen, we examined and characterized variables, including kojic acid and glycine concentration, agar percentage, and pH, to generate a chemically defined minimal medium on which specific inoculums of M...
November 24, 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27874201/follicular-psoriasis-differentiation-from-pityriasis-rubra-pilaris-an-illustrative-case-and-review-of-the-literature
#3
Cuong V Nguyen, Ronda S Farah, Sheilagh M Maguiness, Daniel D Miller
The follicular presentation of psoriasis is a well-described but uncommon variant. In some cases, follicular psoriasis may clinically and histopathologically mimic pityriasis rubra pilaris. There are several reports discussing the resemblance of widespread follicular psoriasis in children to pityriasis rubra pilaris. We describe a case of follicular psoriasis in a 16-year-old black girl with acrally distributed follicular hyperkeratotic papules with associated keratoderma of her plantar surfaces resembling pityriasis rubra pilaris...
November 22, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27867741/pityriasis-rubra-pilaris-like-eruption-following-insulin-therapy-initiation
#4
Talel Badri, Anissa Zaouak, Ghozlane Lakhoua, Wafaa Koubaa, Sami Fennich, Ahmed Zaiem
Pityriasis rubra pilaris (PRP) is a chronic disorder of keratinization of unclear pathogenesis. PRP-like eruptions induced by drugs have rarely been described. A previously healthy 29-year-old man presented with a generalized, rapidly spreading, erythematosquamous dermatosis, that started three days after initiation of subcutaneous insulin therapy for diabetes mellitus type 1. Clinical and histopathological features were consistent with a PRP-like eruption, possibly due to insulin therapy. The patient was switched to insulin analogue therapy and a complete healing of all lesions was achieved after two months...
October 2016: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/27862745/infliximab-induced-cutaneous-eruption-resembling-pityriasis-rubra-pilaris-in-a-patient-with-takayasu-s-arteritis
#5
Andac Salman, Yaman Sonmez, Hulya Sahin, Ali Ugur Unal, Haner Direskeneli, Leyla Cinel, Tulin Ergun
No abstract text is available yet for this article.
November 12, 2016: Dermatologic Therapy
https://www.readbyqxmd.com/read/27862158/the-role-of-interleukin-22-in-pityriasis-rosea
#6
S Al Mokadem, S Ghonemy, A Zidan, G Abd El Aleem
BACKGROUND: Pityriasis rosea (PR) is an exanthematous disease related to reactivation of human herpes virus (HHV) types 6 and 7. The pathogenesis and cytokine profile of PR are still poorly understood.There is a large amount of evidence indicating a viral aetiology for PR. AIM: To measure the serum level of interleukin (IL)-22, a cytokine expressed by T helper (Th)17 cells in patients with PR to explore the possible association of IL-22 with the pathogenesis of the disease...
November 11, 2016: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27828657/pityriasis-amiantacea-a-study-of-seven-cases
#7
Gustavo Moreira Amorim, Nurimar Conceição Fernandes
Pityriasis amiantacea was first described in 1832. The disease may be secondary to any skin condition that primarily affects the scalp, including seborrheic dermatitis. Its pathogenesis remains uncertain. We aim to analyze the epidemiological and clinical profiles of patients with pityriasis amiantacea to better understand treatment responses. We identified seven cases of pityriasis amiantacea and a female predominance in a sample of 63 pediatric patients with seborrheic dermatitis followed for an average of 20...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/27816291/atrophying-pityriasis-versicolor-as-an-idiosyncratic-t%C3%A2-cell-mediated-response-to-malassezia-a-case-series
#8
Jonathan Michael Stephen Levy, Cynthia Magro
BACKGROUND: Atrophying pityriasis versicolor (PV), first described in 1971, is a rare variant in which lesions appear atrophic. OBJECTIVE: We sought to determine the pathophysiology of atrophying PV. METHODS: A retrospective chart review identified 6 cases of atrophying PV. In all cases, routine light microscopy, an elastic tissue stain, and immunohistochemical assessment for the expression of CD3, CD4, CD8, GATA3 and CXCR3 was performed. RESULTS: All cases demonstrated hyperkeratosis with intracorneal infiltration by pathogenic hyphal forms as well as epidermal attenuation and papillary dermal elastolysis...
November 2, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27805921/c-cbl-e3-ubiquitin-ligase-expression-increases-across-the-spectrum-of-benign-and-malignant-t-cell-skin-diseases
#9
Katrin A Salva, Margo J Reeder, Rita Lloyd, Gary S Wood
Prolonged survival of lesional T cells plays a central role in the pathogenesis of T-cell-mediated dermatoses. We have recently shown that the ubiquitin ligase c-CBL is highly expressed in cutaneous T-cell lymphoma (CTCL) and that its knockdown increases activation-induced cell death, a key pathway for T-cell apoptosis. Here, we extend our work on c-CBL expression in malignant T cells to their nonneoplastic counterparts in benign inflammatory dermatoses. Immunohistochemical staining with anti-c-CBL antibody was performed on lesional biopsies from a total of 65 patients with atopic dermatitis, allergic contact dermatitis, pityriasis rosea, psoriasis vulgaris, lichen planus, mycosis fungoides (MF)/Sézary syndrome (SS) as well as on tonsil tissue from 5 individuals and on 5 human CTCL cell lines...
October 31, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27766674/cutaneous-metastasis-of-inflammatory-breast-carcinoma-mimicking-an-erythema-annulare-centrifugum-a-sign-of-locally-recurrent-cancer
#10
V Sabater, F Ferrando, A Morera, L Palomar
Erythema annulare centrifugum (EAC) is a clinical reaction pattern that includes lupus erythematosus, spongiotic dermatitis (particularly pityriasis rosea), pseudolymphoma and cutaneous B-cell lymphoma. However, it can be the result of cutaneous metastasis by an internal carcinoma. We present the case of a 38-year-old woman with bilateral inflammatory breast cancer following multimodal therapy. After chemotherapy, the patient developed EAC on her back, clinically suspect of subacute cutaneous lupus erythematosus...
October 20, 2016: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27760266/pityriasis-rubra-pilaris-type-v-as-an-autoinflammatory-disease-by-card14-mutations
#11
Takuya Takeichi, Kazumitsu Sugiura, Toshifumi Nomura, Taiko Sakamoto, Yasushi Ogawa, Naoki Oiso, Yuko Futei, Aki Fujisaki, Akiko Koizumi, Yumi Aoyama, Kimiko Nakajima, Yutaka Hatano, Kei Hayashi, Akemi Ishida-Yamamoto, Sakuhei Fujiwara, Shigetoshi Sano, Keiji Iwatsuki, Akira Kawada, Yasushi Suga, Hiroshi Shimizu, John A McGrath, Masashi Akiyama
Importance: We found CARD14 mutations (2 de novo novel mutations and another previously reported mutation) in 3 of 3 patients with pityriasis rubra pilaris (PRP) type V, but not in patients with PRP of other types. Our findings, combined with the published literature, suggest that type V PRP, both familial and sporadic, can be caused by CARD14 mutations. Detailed clinical observation revealed that all 3 patients displayed unique patchy macular brown hyperpigmentation. Objective: To further determine how often patients with PRP have pathogenic mutations in CARD14 and to elucidate which clinical subtype of PRP is caused by CARD14 mutations...
October 19, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27746631/pityriasis-lichenoides-like-mycosis-fungoides-clinical-and-histologic-features-and-response-to-phototherapy
#12
Min Soo Jang, Dong Young Kang, Jong Bin Park, Joon Hee Kim, Kwi Ae Park, Hark Rim, Kee Suck Suh
BACKGROUND: Pityriasis lichenoides (PL)-like skin lesions rarely appear as a specific manifestation of mycosis fungoides (MF). OBJECTIVE: We investigated the clinicopathological features, immunophenotypes, and treatments of PL-like MF. METHODS: This study included 15 patients with PL-like lesions selected from a population of 316 patients diagnosed with MF at one institution. RESULTS: The patients were between 4 and 59 years of age...
October 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27739122/efficacy-of-ustekinumab-after-failure-of-infliximab-ct-p13-in-a-hla-cw6-positive-patient-affected-by-pityriasis-rubra-pilaris-monitoring-with-reflectance-confocal-microscopy-rcm-and-optical-coherence-tomography-oct
#13
LETTER
A Paganelli, S Ciardo, G Odorici, G Pellacani, A Conti
No abstract text is available yet for this article.
October 14, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27730050/is-a-treatment-for-pityriasis-rosea-really-needed
#14
Giulia Ciccarese, Francesco Drago
No abstract text is available yet for this article.
September 2016: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/27706476/successful-treatment-of-refractory-pityriasis-rubra-pilaris-with-secukinumab
#15
Daniel Schuster, Andrea Pfister-Wartha, Leena Bruckner-Tuderman, Christoph M Schempp
No abstract text is available yet for this article.
November 1, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27663203/epidemiology-and-fungal-species-distribution-of-superficial-mycoses-in-northeast-brazil
#16
W P Silva-Rocha, M F de Azevedo, G M Chaves
OBJECTIVE: Dermatomycoses are superficial fungal infections which affect the skin, hair and nails of humans and animals. Male and female patients of all ages are affected by this condition. The main etiological agents of dermatomycoses are the dermatophytes fungi of the genera Trichophyton, Microsporum and Epidermophyton, while the main yeasts belong to the genera Candida, Malassezia and Trichosporon. The variation in the distribution of dermatomycoses worldwide justify the conduction of epidemiological studies in order to contribute for the better understanding of patterns of mycological cutaneous infections...
September 20, 2016: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/27648387/dermoscopy-as-a-useful-supportive-tool-for-the-diagnosis-of-pityriasis-amiantacea-like-tinea-capitis
#17
Enzo Errichetti, Giuseppe Stinco
Clinical distinction between pityriasis amiantacea-like tinea capitis and pityriasis amiantacea due to noninfectious inflammatory diseases is a troublesome task, with a significant likelihood of diagnostic errors/delays and prescription of inappropriate therapies. We report a case of pityriasis amiantacea-like tinea capitis with its dermoscopic findings in order to highlight the usefulness of dermoscopy in improving the recognition of such a condition.
July 2016: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/27648382/pityriasis-rosea-in-pregnancy-report-of-a-spousal-occurrence-and-craniosynostosis-in-the-healthy-newborn
#18
REVIEW
Tiffany Y Loh, Philip R Cohen
BACKGROUND: Pityriasis rosea is a papulosquamous disease. It may occur during pregnancy; in this setting, it has occasionally been associated with adverse outcomes. PURPOSE: A woman who developed pityriasis rosea at the beginning of her eighth week of gestation is described. The outcomes in newborns delivered by pregnant women who developed pityriasis rosea during gestation are summarized. METHOD: A 28-year-old woman developed pityriasis rosea during her eighth week of pregnancy...
July 2016: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/27638444/phototherapy-in-children-considerations-and-indications
#19
Cary S Crall, Jillian F Rork, Sophia Delano, Jennifer T Huang
Phototherapy can be a safe and effective treatment for various skin diseases in children. Special considerations governing the use of this treatment modality in pediatric populations include patient, family, and facility-based factors that are oriented around heightened concerns with regard to safety and tolerability of treatment. Although phototherapy has been found to be effective in a wide range of dermatologic conditions affecting pediatric populations, including psoriasis, atopic dermatitis, pityriasis lichenoides, cutaneous T-cell lymphoma, and vitiligo, there is need for additional research on other conditions in which phototherapy has shown promise...
September 2016: Clinics in Dermatology
https://www.readbyqxmd.com/read/27617521/successful-treatment-of-pityriasis-lichenoides-chronica-with-narrow-band-ultraviolet-b-therapy-in-a-patient-with-keratitis-ichthyosis-deafness-syndrome-a-case-report
#20
Andac Salman, Dilek Seckin Gencosmanoglu, Ayse Deniz Yucelten, Nursel Elcioglu, Gabriele Richard, Cuyan Demirkesen
Keratitis-ichthyosis-deafness (KID) syndrome is a rare genodermatosis causing ichthyosis-like skin lesions, keratitis, and deafness. Herein, we report a patient with this rare syndrome in association with pityriasis lichenoides chronica, which was succesfully treated with narrow-band ultraviolet B phototherapy despite our concerns regarding the increased risk of squamous cell carcinoma, hyperpyrexia, and keratitis.
May 15, 2016: Dermatology Online Journal
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