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Laurence Canaple, Aline Gréchez-Cassiau, Franck Delaunay, Ouria Dkhissi-Benyahya, Jacques Samarut
Most living organisms show circadian rhythms in physiology and behavior. These oscillations are generated by endogenous circadian clocks, present in virtually all cells where they control key biological processes. To study peripheral clocks in vivo, we developed an original model, the Rev-Luc mouse to follow noninvasively and longitudinally Rev-Luc oscillations in peripheral clocks using in vivo bioluminescence imaging. We found in vitro and in vivo a robust diurnal rhythm of Rev-Luc, mainly in liver, intestine, kidney and adipose tissues...
May 26, 2018: Cellular and Molecular Life Sciences: CMLS
Shigenobu Shibata, Akiko Furutani
Circadian clock system has been widely maintained in many spices from prokaryote to mammals. "Circadian" means "approximately day" in Latin, thus circadian rhythm means about 24 hour rhythms. The earth revolves once every 24 hours, and our circadian system has been developed for adjusting to this 24 hour cycles, to get sun light information for getting their foods or for alive in birds or mammals. We have two different circadian systems so-called main oscillator located in the suprachiasmatic nucleus (SCN) of the hypothalamus, and local oscillator located in the various peripheral organ tissues such as liver, kidney and skeletal muscle...
2018: Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
Katsutaka Oishi, Tatsuya Konishi, Chiaki Hashimoto, Saori Yamamoto, Yoshinori Takahashi, Yasuhiko Shiina
Chrononutrition is the science of nutrition based on chronobiology. Numerous epidemiological studies have shown that fish oil (FO) reduces the risk of cardiovascular events through various actions such as lowering triglycerides. The present study aimed to determine the time of day when the hypertriglyceridemia-decreasing ability of FO is optimal in mice. A high-fructose diet (HFrD) that induces hyperlipidemia in mice was replaced with the same diet containing 4% FO (HFrD-4% FO) at different times of the day for 2 weeks as described below...
February 2018: Journal of Nutritional Biochemistry
Jonathan D Johnston, José M Ordovás, Frank A Scheer, Fred W Turek
Chrononutrition is an emerging discipline that builds on the intimate relation between endogenous circadian (24-h) rhythms and metabolism. Circadian regulation of metabolic function can be observed from the level of intracellular biochemistry to whole-organism physiology and even postprandial responses. Recent work has elucidated the metabolic roles of circadian clocks in key metabolic tissues, including liver, pancreas, white adipose, and skeletal muscle. For example, tissue-specific clock disruption in a single peripheral organ can cause obesity or disruption of whole-organism glucose homeostasis...
March 2016: Advances in Nutrition
Yu Tahara, Shigenobu Shibata
The circadian clock system consists of a central clock located in the suprachiasmatic nucleus in the hypothalamus and peripheral clocks in peripheral tissues. Peripheral clocks in the liver have fundamental roles in maintaining liver homeostasis, including the regulation of energy metabolism and the expression of enzymes controlling the absorption and metabolism of xenobiotics. Over the past two decades, research has investigated the molecular mechanisms linking circadian clock genes with the regulation of hepatic physiological functions, using global clock-gene-knockout mice, or mice with liver-specific knockout of clock genes or clock-controlled genes...
April 2016: Nature Reviews. Gastroenterology & Hepatology
J Laermans, I Depoortere
Although obesity is considered to result from an imbalance between energy uptake and energy expenditure, the strategy of dietary changes and physical exercise has failed to tackle the global obesity epidemic. In search of alternative and more adequate treatment options, research has aimed at further unravelling the mechanisms underlying this excessive weight gain. While numerous studies are focusing on the neuroendocrine alterations that occur after bariatric Roux-en-Y gastric bypass surgery, an increasing amount of chronobiological studies have started to raise awareness concerning the pivotal role of the circadian system in the development and exacerbation of obesity...
February 2016: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
Hiroaki Oda
Well-regulated eating habits are said to be important for health. A major breakthrough was the discovery of the negative regulatory feedback for transcription via the binding of Clock/Bmal1 to E-box, which forms the basis of biological clocks. Well-regulated eating habits normalize the liver clock gene, the rhythm of CYP7A1 gene, and blood cholesterol levels through insulin secretion. Moreover, well-regulated eating habits actively contribute to better lipid metabolism such as obesity, even if animals ingest a high-fat diet...
2015: Journal of Nutritional Science and Vitaminology
Yoko Watanabe, Isao Saito, Ikuyo Henmi, Kana Yoshimura, Kotatsu Maruyama, Kanako Yamauchi, Tatsuhiro Matsuo, Tadahiro Kato, Takeshi Tanigawa, Taro Kishida, Yasuhiko Asada
OBJECTIVE: Despite the fact that the total energy intake of Japanese people has decreased, the percentage of obese people has increased. This suggests that the timing of meals is related to obesity. The purpose of the study was to investigate the relationship between the timing of meals and obesity, based on analyses of physical measurements, serum biochemical markers, nutrient intake, and lifestyle factors in the context of Chrononutrition. PARTICIPANTS AND METHODS: We analyzed data derived from 766 residents of Toon City (286 males and 480 females) aged 30 to 79 years who underwent detailed medical examinations between 2011 and 2013...
2014: Journal of Rural Medicine: JRM
Hideaki Oike, Katsutaka Oishi, Masuko Kobori
Circadian clocks that comprise clock genes exist throughout the body and control daily physiological events. The central clock that dominates activity rhythms is entrained by light/dark cycles, whereas peripheral clocks regulating local metabolic rhythms are determined by feeding/fasting cycles. Nutrients reset peripheral circadian clocks and the local clock genes control downstream metabolic processes. Metabolic states also affect the clockworks in feedback manners. Because the circadian system organizes whole energy homeostasis, including food intake, fat accumulation, and caloric expenditure, the disruption of circadian clocks leads to metabolic disorders...
2014: Current Nutrition Reports
M Garrido, M P Terrón, A B Rodríguez
Free radicals and oxidative stress have been recognized as important factors in the biology of aging and in many age-associated degenerative diseases. Antioxidant systems deteriorate during aging. It is, thus, considered that one way to reduce the rate of aging and the risk of chronic disease is to avoid the formation of free radicals and reduce oxidative stress by strengthening antioxidant defences. Phytochemicals present in fruits, vegetables, grains, and other foodstuffs have been linked to reducing the risk of major oxidative stress-induced diseases...
2013: Oxidative Medicine and Cellular Longevity
Yasushi Tanaka
No abstract text is available yet for this article.
April 10, 2013: Nihon Naika Gakkai Zasshi. the Journal of the Japanese Society of Internal Medicine
Sertac Arslanoglu, Enrico Bertino, Margherita Nicocia, Guido E Moro
BACKGROUND: Organization of the sleep states and a normal sleep pattern in the neonatal period and early infancy is essential for brain development and plasticity. The establishment of a consolidated circadian sleep-wake cycle occurs between 1 and 4 months of life in term infants. This period may be even longer for preterm infants who are exposed to relentless interventions in neonatal intensive care units. The sleep should be respected and protected. OBJECTIVE AND METHODS: Human milk (HM) contains bioactive sleep-promoting components, and recent evidence shows that some of these components show circadian oscillations...
January 2012: Journal of Perinatal Medicine
R Bravo, S Matito, J Cubero, S D Paredes, L Franco, M Rivero, A B Rodríguez, C Barriga
Melatonin and serotonin rhythms, which exhibit a close association with the endogenous circadian component of sleep, are attenuated with increasing age. This decrease seems to be linked to sleep alterations in the elderly. Chrononutrition is a field of chronobiology that establishes the principle of consuming foodstuffs at times of the day when they are more useful for health, improving, therefore, biorhythms and physical performance. Our aim was to analyze whether the consumption of cereals enriched with tryptophan, the precursor of both serotonin and melatonin, may help in the reconsolidation of the sleep/wake cycle and counteract depression and anxiety in 35 middle-aged/elderly (aged 55-75 year) volunteers in a simple blind assay...
August 2013: Age (2005-)
M A Zulet, I Bondia-Pons, I Abete, R de la Iglesia, P López-Legarrea, L Forga, S Navas-Carretero, J A Martínez
INTRODUCTION: The high prevalence of metabolic syndrome (MS) in Spain requires additional efforts for prevention and treatment. OBJECTIVE: The study RESMENA-S aims to improve clinical criteria and biomarkers associated with MS though an integral therapy approach. METHODS: The study is a randomized prospective parallel design in which is expected to participate a total of 100 individuals. The RESMENA-S group (n = 50) is a personalized weight loss (30% energy restriction) diet, with a macronutrient distribution (carbohydrate / fat / protein) of 40/30/30, high meal frequency (7 / day), low glycemic index/load and high antioxidant capacity as well as a high adherence to the Mediterranean diet...
January 2011: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Hideo Kato, Kiyoka Kuninobu, Aiko Saito, Kanae Ideguchi, Yuka Nishida, Haruka Kato
No abstract text is available yet for this article.
March 2011: Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
Shigenobu Shibata, Akiko Hirao
No abstract text is available yet for this article.
March 2011: Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
Javier Cubero, Belen Chanclón, Soledad Sánchez, Montserrat Rivero, Ana Beatriz Rodríguez, Carmen Barriga
The present study evaluated whether the administration of cereals enriched with nutrients that are facilitators of sleep could help improve the sleep of infants who had sleep disorders at night time. Thirty infants aged 8-16 months with sleep disorders involving at least three nocturnal waking episodes took part in the study. They were given a night-time 'sleep facilitating cereal' product containing 225 mg tryptophan, 5.3 mg adenosine-5'-P, and 6.3 mg uridine-5'-P per 100 g of product. These cereals were given in a double-blind procedure lasting 5 weeks, with ingestion of the cereal between 18:00 and 06:00...
December 2009: Nutritional Neuroscience
Sara Aparicio, Celia Garau, Susana Esteban, María C Nicolau, Montserrat Rivero, Rubén V Rial
Three different lactation experiments have been tested in a double blind procedure for 3 weeks, to improve sleep-wake patterns in infants. In a control experiment, standard infant commercial milk (1.5% tryptophan) was administered without changes during the day. In a second control (inverse), enriched milk (3.4% tryptophan) was given during light-time (06.00-18.00h), and standard commercial milk during night-time (18.00-06.00h). During the experimental week, the infants received standard milk during light-time and tryptophan enriched milk during night-time...
June 2007: Nutritional Neuroscience
Javier Cubero, D Narciso, Pilar Terrón, Ruben Rial, Susana Esteban, Montserrat Rivero, H Parvez, Ana B Rodríguez, Carmen Barriga
UNLABELLED: Some 30% of pre-weaning infants present problems of sleep during the night, especially those who are bottle-fed. The solution is for them to be breast-fed for as long as possible, or, if this is not possible, for the formula milk to reproduce breast-milk's natural circadian variations in the concentrations of tryptophan and those nucleotides which have a beneficial effect in consolidating the circadian sleep-wake cycle. OBJECTIVE: To study in pre-weaning infants the effect on nocturnal sleep of the administration of formula milk dissociated into its day/night components...
August 2007: Neuro Endocrinology Letters
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