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https://read.qxmd.com/read/38484117/nutritional-composition-and-therapeutic-potential-of-pineapple-peel-a-comprehensive-review
#1
JOURNAL ARTICLE
Arshad Farid, Mahrukh Mehraj, Susmita Das, Fathima Feroz, Ab Waheed Wani, S Q Dar, Sanjeev Kumar, Atif Khurshid Wani
Pineapple (Ananas comosus), the succulent and vibrant tropical fruit, is a symbol of exoticism and sweetness. The pineapple peel, often considered as waste, has garnered attention for its potential applications. The pineapple peel is rich in essential nutrients, including calcium, potassium, vitamin C, carbohydrates, dietary fiber, and water, making it beneficial for the digestive system, weight management, and overall balanced nutrition. It contains significant amounts of sugars such as sucrose, glucose, and fructose, along with citric acid as the predominant organic acid...
March 14, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38479983/in-depth-multiomic-characterization-of-the-effects-of-obesity-in-high-fat-diet-fed-mice
#2
JOURNAL ARTICLE
Boping Li, Juanjuan Chen, Xiaobin Ou, Xiuli Liu, Zaoxu Xu, Xuesong Xiang, Yan Yang, Qi Wang
High-fat diet (HFD)-fed mice have been widely used in the clinical investigation of obesity. However, the long-term effect of HFD on gut microbiota and metabolites, plasma and liver metabolomics, colonic and liver transcriptomics remain largely unknown. In this study, 6-week-old C57BL/6J male mice fed with HFD for 14 weeks showed increased obesity-related indexes including alanine aminotransferase, aspartate aminotransferase, total cholesterol, total triglyceride, free fatty acids, lipopolysaccharides, IL-6, and TNFα...
March 13, 2024: FEBS Open Bio
https://read.qxmd.com/read/38475720/tracing-vitamins-on-the-long-non-coding-lane-of-the-transcriptome-vitamin-regulation-of-lncrnas
#3
REVIEW
Fatemeh Yazarlou, Fatemeh Alizadeh, Leonard Lipovich, Roberta Giordo, Soudeh Ghafouri-Fard
A major revelation of genome-scale biological studies in the post-genomic era has been that two-thirds of human genes do not encode proteins. The majority of non-coding RNA transcripts in humans are long non-coding RNA (lncRNA) molecules, non-protein-coding regulatory transcripts with sizes greater than 500 nucleotides. LncRNAs are involved in nearly every aspect of cellular physiology, playing fundamental regulatory roles both in normal cells and in disease. As result, they are functionally linked to multiple human diseases, from cancer to autoimmune, inflammatory, and neurological disorders...
March 12, 2024: Genes & Nutrition
https://read.qxmd.com/read/38474883/risk-of-excess-maternal-folic-acid-supplementation-in-offspring
#4
REVIEW
Xiguang Xu, Ziyu Zhang, Yu Lin, Hehuang Xie
Folate, also known as vitamin B9, facilitates the transfer of methyl groups among molecules, which is crucial for amino acid metabolism and nucleotide synthesis. Adequate maternal folate supplementation has been widely acknowledged for its pivotal role in promoting cell proliferation and preventing neural tube defects. However, in the post-fortification era, there has been a rising concern regarding an excess maternal intake of folic acid (FA), the synthetic form of folate. In this review, we focused on recent advancements in understanding the influence of excess maternal FA intake on offspring...
March 6, 2024: Nutrients
https://read.qxmd.com/read/38418937/transcription-factor-encoding-gene-osc1-regulates-leaf-sheath-color-through-anthocyanidin-metabolism-in-oryza-rufipogon-and-oryza-sativa
#5
JOURNAL ARTICLE
Liqun Jiang, Shuwei Lyu, Hang Yu, Jing Zhang, Bingrui Sun, Qing Liu, Xingxue Mao, Pingli Chen, Dajian Pan, Wenfeng Chen, Zhilan Fan, Chen Li
Carbohydrates, proteins, lipids, minerals and vitamins are nutrient substances commonly seen in rice grains, but anthocyanidin, with benefit for plant growth and animal health, exists mainly in the common wild rice but hardly in the cultivated rice. To screen the rice germplasm with high intensity of anthocyanidins and identify the variations, we used metabolomics technique and detected significant different accumulation of anthocyanidins in common wild rice (Oryza rufipogon, with purple leaf sheath) and cultivated rice (Oryza sativa, with green leaf sheath)...
February 28, 2024: BMC Plant Biology
https://read.qxmd.com/read/38404006/one-carbon-metabolism-nutrients-impact-the-interplay-between-dna-methylation-and-gene-expression-in-liver-enhancing-protein-synthesis-in-atlantic-salmon
#6
JOURNAL ARTICLE
Takaya Saito, Marit Espe, Vibeke Vikeså, Christoph Bock, Tårn H Thomsen, Anne-Catrin Adam, Jorge M O Fernandes, Kaja H Skjaerven
Supplementation of one-carbon (1C) metabolism micronutrients, which include B-vitamins and methionine, is essential for the healthy growth and development of Atlantic salmon ( Salmo salar ). However, the recent shift towards non-fish meal diets in salmon aquaculture has led to the need for reassessments of recommended micronutrient levels. Despite the importance of 1C metabolism in growth performance and various cellular regulations, the molecular mechanisms affected by these dietary alterations are less understood...
December 2024: Epigenetics: Official Journal of the DNA Methylation Society
https://read.qxmd.com/read/38401163/plant-iron-status-regulates-ammonium-use-efficiency-through-protein-n-glycosylation
#7
JOURNAL ARTICLE
Guangjie Li, Lin Zhang, Jinlin Wu, Zhaoyue Wang, Meng Wang, Herbert J Kronzucker, Weiming Shi
Improving nitrogen-use efficiency (NUE) is an important path toward enhancing crop yield and alleviating the environmental impacts of fertilizer use. Ammonium (NH4+) is the energetically preferred inorganic N source for plants. The interaction of NH4+ with other nutrients is a chief determinant of ammonium-use efficiency (AUE) and of the tipping point toward ammonium toxicity, but these interactions have remained ill-defined. Here, we report that iron (Fe) accumulation is a critical factor determining AUE and have identified a substance that can enhance AUE by manipulating Fe availability...
February 24, 2024: Plant Physiology
https://read.qxmd.com/read/38398891/ancestry-specific-polygenic-risk-score-dietary-patterns-physical-activity-and-cardiovascular-disease
#8
JOURNAL ARTICLE
Dale Hardy, Jane Garvin, Tesfaye Mersha
It is unknown whether the impact of high diet quality and physical activity depends on the level of polygenic risk score (PRS) in different ancestries. Our cross-sectional study utilized de-identified data from 1987-2010 for self-reported European Americans (n = 6575) and African Americans (n = 1606). The high-risk PRS increased ASCVD risk by 59% (Risk Ratio (RR) = 1.59; 95% Confidence Interval:1.16-2.17) in the highest tertile for African Americans and by 15% (RR = 1.15; 1.13-1.30) and 18% (RR = 1.18; 1.04-1...
February 19, 2024: Nutrients
https://read.qxmd.com/read/38397099/from-the-friend-to-the-foe-enterococcus-faecalis-diverse-impact-on-the-human-immune-system
#9
REVIEW
Agnieszka Daca, Tomasz Jarzembowski
Enterococcus faecalis is a bacterium which accompanies us from the first days of our life. As a commensal it produces vitamins, metabolizes nutrients, and maintains intestinal pH. All of that happens in exchange for a niche to inhabit. It is not surprising then, that the bacterium was and is used as an element of many probiotics and its positive impact on the human immune system and the body in general is hard to ignore. This bacterium has also a dark side though. The plasticity and relative ease with which one acquires virulence traits, and the ability to hide from or even deceive and use the immune system to spread throughout the body make E...
February 19, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38363439/uncovering-potentially-therapeutic-phytochemicals-in-silico-analysis-and-biological-assessment-of-south-chinese-red-dragon-fruit-hylocereus-polyrhizus
#10
JOURNAL ARTICLE
Ali Asghar, Lin Huichun, Qiao Fang, Naveed Ahmad Khan, Muhammad Shahid, Wang Rui, Wang Jun
Red dragon fruit is gaining popularity globally due to its nutritional value and bioactive components. The study aimed to assess the phytochemical, nutritional composition, antioxidant, antibacterial, and cytotoxic properties of extracts from the South Chinese red dragon fruit peel, flesh, and seeds. Extract fractions with increasing polarity (ethyl acetate<acetone<ethanol<methanol) were prepared. Significant amounts of nutritional components (minerals, protein, sugars, vitamins, fatty acids) were found in all parts of the fruit...
February 16, 2024: Plant Foods for Human Nutrition
https://read.qxmd.com/read/38362517/dietary-fibre-effects-and-the-interplay-with-exogenous-carbohydrases-in-poultry-nutrition
#11
REVIEW
Michael R Bedford, Birger Svihus, Aaron J Cowieson
A comprehensive understanding of the role of dietary fibre in non-ruminant animal production is elusive. Equivocal and conflated definitions of fibre coupled with significant analytical complexity, interact with poorly defined host and microbiome relationships. Dietary fibre is known to influence gut development, feed intake and passage rate, nutrient absorption, microbiome taxonomy and function, gut pH, endogenous nutrient loss, environmental sustainability, animal welfare and more. Whilst significant gaps persist in our understanding of fibre in non-ruminant animal production, there is substantial interest in optimizing the fibre fraction of feed to induce high value phenotypes such as improved welfare, live performance and to reduce the environmental footprint of animal production systems...
March 2024: Animal Nutrition
https://read.qxmd.com/read/38353331/therapeutic-potential-of-tocotrienols-as-chemosensitizers-in-cancer-therapy
#12
REVIEW
Bethsebie Lalduhsaki Sailo, Suravi Chauhan, Mangala Hegde, Sosmitha Girisa, Mohammed S Alqahtani, Mohamed Abbas, Arul Goel, Gautam Sethi, Ajaikumar B Kunnumakkara
Chemoresistance is the adaptation of cancer cells against therapeutic agents. When exhibited by cancer cells, chemoresistance helps them to avoid apoptosis, cause relapse, and metastasize, making it challenging for chemotherapeutic agents to treat cancer. Various strategies like dosage modification of drugs, nanoparticle-based delivery of chemotherapeutics, antibody-drug conjugates, and so on are being used to target and reverse chemoresistance, one among such is combination therapy. It uses the combination of two or more therapeutic agents to reverse multidrug resistance and improve the effects of chemotherapy...
February 14, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38339178/calcium-phosphorus-and-vitamin-d-levels-in-a-series-of-cystic-fibrosis-patients-a-cross-sectional-study
#13
JOURNAL ARTICLE
Marlene Fabiola Escobedo-Monge, Marianela Marcos-Temprano, Joaquín Parodi-Román, María Antonieta Escobedo-Monge, Carmen Alonso-Vicente, María Carmen Torres-Hinojal, José Manuel Marugán-Miguelsanz
Cystic fibrosis (CF) is a monogenic disease with different types of mutations that mainly affect the respiratory-digestive system. Calcium (Ca), phosphorus (P), and vitamin D (Vit-D) are essential nutrients for maintaining adequate growth and development, as well as key components in crucial metabolic pathways. Proper diagnosis, treatment, and response are decisive components of precision medicine. Therefore, we conducted a cross-sectional study to evaluate Ca, P, and Vit-D levels along with health and nutritional indicators, regarding their non-skeletal functions, in a series of CF patients...
February 5, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38338979/metabonomics-and-transcriptomic-analysis-of-free-fatty-acid-synthesis-in-seedless-and-tenera-oil-palm
#14
JOURNAL ARTICLE
Lu Wei, Cheng Yang, Jerome Jeyakumar John Martin, Rui Li, Lixia Zhou, Shuanghong Cheng, Hongxing Cao, Xiaoyu Liu
Oil palm, a tropical woody oil crop, is widely used in food, cosmetics, and pharmaceuticals due to its high production efficiency and economic value. Palm oil is rich in free fatty acids, polyphenols, vitamin E, and other nutrients, which are beneficial for human health when consumed appropriately. Therefore, investigating the dynamic changes in free fatty acid content at different stages of development and hypothesizing the influence of regulatory genes on free fatty acid metabolism is crucial for improving palm oil quality and accelerating industry growth...
January 30, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38337681/serum-25-hydroxyvitamin-d-is-inversely-associated-with-nasopharyngeal-carcinoma-a-hospital-based-matched-case-control-study-in-malaysia
#15
JOURNAL ARTICLE
Vaidehi Ulaganathan, Munn Sann Lye, Su Peng Loh, Yoke Yeow Yap, Mirnalini Kandiah, Digsha Augundhooa, Tanima Bhattacharya, Ebtesam Al-Olayan, Chuanyi Wang
Serum 25(OH)D deficiency consistently demonstrated molecular mechanisms through which chronic inflammation is associated with the risk of nasopharyngeal carcinoma (NPC). This study aimed to determine the association between serum 25(OH)D and NPC. A matched case-control study was conducted at two local hospitals. A total of 300 histologically confirmed NPC cases were matched with controls for age, gender, and ethnicity, and assessed for vitamin D status and other nutritional factors. Mean Vitamin D concentration was significantly lower among cases compared to controls (63...
January 30, 2024: Nutrients
https://read.qxmd.com/read/38337625/the-roles-of-micrornas-in-asthma-and-emerging-insights-into-the-effects-of-vitamin-d-3-supplementation
#16
REVIEW
Adrián Hernández-Díazcouder, Rodrigo Romero-Nava, Blanca E Del-Río-Navarro, Fausto Sánchez-Muñoz, Carlos A Guzmán-Martín, Nayely Reyes-Noriega, Octavio Rodríguez-Cortés, José J Leija-Martínez, Juan Manuel Vélez-Reséndiz, Santiago Villafaña, Enrique Hong, Fengyang Huang
Asthma is one of the most common chronic non-communicable diseases worldwide, characterized by variable airflow limitation secondary to airway narrowing, airway wall thickening, and increased mucus resulting from chronic inflammation and airway remodeling. Current epidemiological studies reported that hypovitaminosis D is frequent in patients with asthma and is associated with worsening the disease and that supplementation with vitamin D3 improves asthma symptoms. However, despite several advances in the field, the molecular mechanisms of asthma have yet to be comprehensively understood...
January 24, 2024: Nutrients
https://read.qxmd.com/read/38296498/-prevention-and-treatment-of-cancer-with-vitamin-a-and-its-derivatives-cell-differentiation-and-proliferation
#17
JOURNAL ARTICLE
Noriko Takahashi
Normal differentiation and proliferation of cells are essential for maintaining homeostasis. Following the successful completion of whole genome sequencing, protein modification has been attracted increasing attention in order to understand the roles of protein diversification in protein function and to elucidate molecular targets in mechanisms of signal transduction. Vitamin A is an essential nutrient for health maintenance. It is present as β-carotene in green and yellow vegetables and retinyl ester in animal products and absorbed into the body from the intestines...
2024: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://read.qxmd.com/read/38279228/modulation-of-the-gut-microbiota-by-nutrition-and-its-relationship-to-epigenetics
#18
REVIEW
Katarzyna Ferenc, Aneta Sokal-Dembowska, Kacper Helma, Elżbieta Motyka, Sara Jarmakiewicz-Czaja, Rafał Filip
The intestinal microbiota is a community of microorganisms inhabiting the human intestines, potentially influencing both physiological and pathophysiological processes in the human body. Existing evidence suggests that nutrients can influence the modulation of the gut microbiota. However, there is still limited evidence regarding the effects of vitamin and mineral supplementation on the human gut microbiota through epigenetic modification. It is plausible that maintaining an adequate dietary intake of vitamin D, iron, fibre, zinc and magnesium may have a beneficial effect on alleviating inflammation in the body, reducing oxidative stress, and improving the condition of the intestinal microbiota through various epigenetic mechanisms...
January 19, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38270702/vitamin-d-and-potential-effects-on-cancers-a-review
#19
REVIEW
Pouria Sobhi, Mohammad Bahrami, Faraz Mahdizadeh, Aliakbar Fazaeli, Ghader Babaei, Lotfollah Rezagholizadeh
Cancer is characterized by the abnormal and uncontrollable division and growth of cells that can infiltrate tissues and alter normal physiological function, which will become crucial and life-threatening if left untreated. Cancer can be a result of genetics, such as mutations or environmental causes, including smoking, lack of physical activity, as well as nutritional imbalance in the body. Vitamin D is one of the foremost nutrients that play a crucial role in a variety of biochemical pathways, and it is an important key factor in several diseases...
January 25, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38257081/human-nutrition-research-in-the-data-era-results-of-11-reports-on-the-effects-of-a-multiple-micronutrient-intervention-study
#20
REVIEW
Jim Kaput, Jacqueline Pontes Monteiro
Large datasets have been used in molecular and genetic research for decades, but only a few studies have included nutrition and lifestyle factors. Our team conducted an n-of-1 intervention with 12 vitamins and five minerals in 9- to 13-year-old Brazilian children and teens with poor healthy-eating indices. A unique feature of the experimental design was the inclusion of a replication arm. Twenty-six types of data were acquired including clinical measures, whole-genome mapping, whole-exome sequencing, and proteomic and a variety of metabolomic measurements over two years...
January 5, 2024: Nutrients
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