keyword
https://read.qxmd.com/read/37978103/new-perspective-on-the-interaction-behavior-between-riboflavin-and-%C3%AE-lactoglobulin-%C3%AE-casein-complex-by-biophysical-techniques
#21
JOURNAL ARTICLE
Farzaneh Samandar, Sara Malek-Mohammadi, Zahra Aram, Farangis Rastin, Shakiba Tolou-Shikhzadeh-Yazdi, Zeinab Amiri-Tehranizadeh, Mohammad Reza Saberi, Jamshidkhan Chamani
Riboflavin (RF) is a vitamin that only exists in plants and microorganisms and must be procured externally by humans. On the other hand, there are two major allergic factors in cow's milk, including β-lactoglobulin (βLG) and β-casein (βCN), while their allergic properties can be eliminated by binding to micronutrients. In this regard, we examined the binding process of RF to βLG and βCN in the binary and ternary systems by different spectroscopies such as zeta potential, electric conductivity, and molecular modeling...
November 17, 2023: Cell Biochemistry and Biophysics
https://read.qxmd.com/read/37964873/from-seeds-to-survival-rates-investigating-linum-usitatissimum-s-potential-against-ovarian-cancer-through-network-pharmacology
#22
JOURNAL ARTICLE
Mohammed Monirul Islam, Nagaraja Sreeharsha, Fahad M Alshabrmi, Afzal Haq Asif, Bandar Aldhubiab, Md Khalid Anwer, Rajendiran Krishnasamy, Abdur Rehman
Ovarian cancer is a malignant tumor that primarily forms in the ovaries. It often goes undetected until it has spread to the pelvis and abdomen, making it more challenging to treat and often fatal. Historically, natural products and their structural analogues have played a pivotal role in pharmacotherapy, especially for cancer. Numerous studies have demonstrated the therapeutic potential of Linum usitatissimum against ovarian cancer, but the specific molecular mechanisms remain elusive. This study combines data mining, network pharmacology, and molecular docking analysis to pioneer an innovative approach for ovarian cancer treatment by identifying potent phytochemicals...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/37958826/molecular-mechanism-biomarkers-predict-diagnosis-in-schizophrenia-and-schizoaffective-psychosis-with-implications-for-treatment
#23
JOURNAL ARTICLE
Stephanie Fryar-Williams, Graeme Tucker, Jörg Strobel, Yichao Huang, Peter Clements
Diagnostic uncertainty and relapse rates in schizophrenia and schizoaffective disorder are relatively high, indicating the potential involvement of other pathological mechanisms that could serve as diagnostic indicators to be targeted for adjunctive treatment. This study aimed to seek objective evidence of methylenetetrahydrofolate reductase MTHFR C677T genotype-related bio markers in blood and urine. Vitamin and mineral cofactors related to methylation and indolamine-catecholamine metabolism were investigated...
October 31, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37948935/study-of-relations-between-chemical-colour-and-fluorescence-properties-of-raw-and-dried-meat-powders-of-cow-and-yak-bos-grunniens
#24
JOURNAL ARTICLE
Zh E Ozbekova, A A Abdyldaev, A A Kulmyrzaev
Gluteus medius, Longissimus thoracis, and Semitendinosus muscles from the cow and yak (Bos grunniens) reared in the Kyrgyz Republic were dried by convective (hot air) drying and freeze drying. The dried muscles were grinded into fine powders and along with raw muscles were evaluated for water activity (aW ), chemical composition (moisture, fat, protein), colour characteristics (L, a, and b values), fluorescence of intrinsic fluorophores (tryptophan, vitamin A, and riboflavin). Processing of measured data tables using common components and specific weights analysis (CCSWA) showed close relations among the chemical, colour, and fluorescence data...
November 4, 2023: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://read.qxmd.com/read/37934564/elucidating-multiple-electron-transfer-pathways-for-metavanadate-bioreduction-by-actinomycetic-streptomyces-microflavus
#25
JOURNAL ARTICLE
Shixiang Wang, Baogang Zhang, Yangmei Fei, Huan Liu, Yi Zhao, Huaming Guo
While microbial reduction has gained widespread recognition for efficiently remediating environments polluted by toxic metavanadate [V(V)], the pool of identified V(V)-reducing strains remains rather limited, with the vast majority belonging to bacteria and fungi. This study is among the first to confirm the V(V) reduction capability of Streptomyces microflavus , a representative member of ubiquitous actinomycetes in environment. A V(V) removal efficiency of 91.0 ± 4.35% was achieved during 12 days of operation, with a maximum specific growth rate of 0...
November 7, 2023: Environmental Science & Technology
https://read.qxmd.com/read/37894974/molecular-mechanisms-provide-a-landscape-for-biomarker-selection-for-schizophrenia-and-schizoaffective-psychosis
#26
REVIEW
Stephanie Fryar-Williams, Jörg Strobel, Peter Clements
Research evaluating the role of the 5,10-methylenetetrahydrofolate reductase ( MTHFR C677T ) gene in schizophrenia has not yet provided an extended understanding of the proximal pathways contributing to the 5-10-methylenetetrahydrofolate reductase (MTHFR) enzyme's activity and the distal pathways being affected by its activity. This review investigates these pathways, describing mechanisms relevant to riboflavin availability, trace mineral interactions, and the 5-methyltetrahydrofolate (5-MTHF) product of the MTHFR enzyme...
October 18, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37880581/b-vitamins-related-vitamers-and-metabolites-in-patients-with-quiescent-inflammatory-bowel-disease-and-chronic-fatigue-treated-with-high-dose-oral-thiamine
#27
RANDOMIZED CONTROLLED TRIAL
Palle Bager, Christian Lodberg Hvas, Mette Mejlby Hansen, Per Ueland, Jens Frederik Dahlerup
BACKGROUND: High doses of oral thiamine improve clinical fatigue scores in patients with quiescent inflammatory bowel disease (IBD) and chronic fatigue. In this study we analysed plasma samples obtained in a randomised clinical trial and aimed compare levels of vitamins B1, B2, B3 and B6, and their related vitamers and metabolites in patients with IBD, with or without chronic fatigue and with or without effect of high dose oral thiamine for chronic fatigue. METHODS: Blood samples from patients with fatigue were drawn prior and after thiamine exposure and only once for patients without fatigue...
October 25, 2023: Molecular Medicine
https://read.qxmd.com/read/37859806/collagen-crosslinking-impacts-stromal-wound-healing-and-haze-formation-in-a-rabbit-phototherapeutic-keratectomy-model
#28
JOURNAL ARTICLE
Bret A Moore, Iman Jalilian, Soohyun Kim, Makiko Mizutani, Madison Mukai, Connor Chang, Alec M Entringer, Kamesh Dhamodaran, Vijay Krishna Raghunathan, Leandro B C Teixeira, Christopher J Murphy, Sara M Thomasy
PURPOSE: The purpose of this study was to evaluate the elastic modulus, keratocyte-fibroblast-myocyte transformation, and haze formation of the corneal stroma following combined phototherapeutic keratectomy (PTK) and epithelium-off UV-A/riboflavin corneal collagen crosslinking (CXL) using an in vivo rabbit model. METHODS: Rabbits underwent PTK and CXL, PTK only, or CXL 35 days before PTK. Rebound tonometry, Fourier-domain optical coherence tomography, and ultrasound pachymetry were performed on days 7, 14, 21, 42, 70, and 90 post-operatively...
2023: Molecular Vision
https://read.qxmd.com/read/37852799/alkyne-oxidation-by-a-vitamin-b2-based-photocatalytic-system-with-both-h-2-o-and-o-2-as-the-oxygen-source
#29
JOURNAL ARTICLE
Duyi Shen, Fubi Zhong, Ting Ren, Linghui Li, Zihan Li, Junzhong Yin, Peiwei Gong, Fanjun Zhang, Chengwei Lv, Mianran Chao
The employment of readily available photocatalysts and green oxygen atom sources is recognized as a promising strategy to develop sustainable catalysis for oxidation reactions. We herein reported a sacrificial reagent-free system consisting of riboflavin tetraacetate (RFT), an ester of natural vitamin B2 as the photocatalyst, and Sc(OTf)3 and NaCl as the cocatalysts for alkyne oxidation under blue light or even sunlight irradiation to produce 1,2-diketone in which the oxygen atoms were from both water and molecular oxygen, respectively...
October 18, 2023: Journal of Organic Chemistry
https://read.qxmd.com/read/37850116/compositional-profiling-and-molecular-docking-studies-of-eucalyptus-polybrachtea-essential-oil-against-mucormycosis-and-aspergillosis
#30
JOURNAL ARTICLE
Arun Dev Sharma, Inderjeet Kaur, Amrita Chauhan
Essential oil (EO) from Eucalyptus polybrachtea is used as complementary and traditional medicine worldwide. The present study aimed at compositional profiling of EO and molecular docking of EO's bioactive compound 1,8 cineole against fungal enzymes involved in the riboflavin synthesis pathway, namely riboflavin synthase (RS), riboflavin biosynthesis protein RibD domain-containing protein (RibD), and 3,4-dihydroxy-2-butanone 4-phosphate synthase (DBPS) as apposite sites for drug designing against aspergillosis and mucormycosis, and in vitro confirmation...
2023: Biotechnologia
https://read.qxmd.com/read/37839053/a-novel-eco-friendly-polymeric-photosensitizer-based-on-chitosan-and-flavin-mononucleotide
#31
JOURNAL ARTICLE
Julieta Sacchetto, Eduardo Gutierrez, Guillermo F Reta, Eduardo Gatica, Sandra Miskoski, María P Montaña, José Natera, Walter A Massad
Flavin mononucleotide (FMN) is a dye belonging to the flavin family. These dyes produce photosensitized degradation of organic compounds via reaction with the excited states of the dye or with reactive oxygen species photogenerated from the triplet of the dye. This article presents a new polymeric dye (FMN-CS) composed of the photosensitizer FMN covalently bonded to chitosan polysaccharide (CS). FMN-CS obtained has a molecular weight of 230 × 103  g mol-1 and a deacetylation degree of 74...
October 15, 2023: Photochemical & Photobiological Sciences
https://read.qxmd.com/read/37835762/molecular-characteristics-and-polymorphisms-of-buffalo-bubalus-bubalis-abcg2-gene-and-its-role-in-milk-fat-synthesis
#32
JOURNAL ARTICLE
Fangting Zhou, Xinyang Fan, Xiaoqi Xu, Zhuoran Li, Lihua Qiu, Yongwang Miao
The ATP-binding cassette subfamily G member 2 ( ABCG2 ) serves crucial roles in secreting riboflavin and biotin vitamins into the milk of cattle, mice, and humans, as well as in the transportation of xenotoxic and cytostatic drugs across the plasma membrane. However, the specific role of the ABCG2 gene in water buffaloes ( Bubalus bubalis ), especially its effect on milk fat synthesis in buffalo mammary epithelial cells (BuMECs), remains inadequately understood. In this study, the full-length CDS of the buffalo ABCG2 gene was isolated and identified from the mammary gland in buffaloes...
October 9, 2023: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/37811763/exploring-therapeutic-targets-and-drug-candidates-for-obesity-a-combined-network-pharmacology-bioinformatics-approach
#33
JOURNAL ARTICLE
Bandar Aloufi, Fahad M Alshabrmi, Nagaraja Sreeharsha, Abdur Rehman
The remarkably high prevalence of obesity in Saudi Arabia reflects a global epidemic demanding urgent attention due to its associated health risks. The integration of traditional medicine, a vital cultural aspect, involves the use of medicinal plants to address various diseases, including obesity. This research merges network pharmacology (NP) and bioinformatics to innovate obesity treatment by identifying effective phytochemicals from native plants in the Taif valley. Focusing on six indigenous plants- Senna alexandrina, Capsicum annuum, Zingiber officinale, Curcuma longa, Trigonella foenum-graecum, and Foeniculum vulgare -we conducted preliminary screenings for potential bioactive compounds...
October 9, 2023: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/37762532/transcriptomic-and-metabolomic-analyses-reveal-the-key-genes-related-to-shade-tolerance-in-soybean
#34
JOURNAL ARTICLE
Aohua Jiang, Jiaqi Liu, Weiran Gao, Ronghan Ma, Jijun Zhang, Xiaochun Zhang, Chengzhang Du, Zelin Yi, Xiaomei Fang, Jian Zhang
Soybean ( Glycine max ) is an important crop, rich in proteins, vegetable oils and several other phytochemicals, which is often affected by light during growth. However, the specific regulatory mechanisms of leaf development under shade conditions have yet to be understood. In this study, the transcriptome and metabolome sequencing of leaves from the shade-tolerant soybean 'Nanxiadou 25' under natural light (ND1) and 50% shade rate (SHND1) were carried out, respectively. A total of 265 differentially expressed genes (DEGs) were identified, including 144 down-regulated and 121 up-regulated genes...
September 18, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37756065/a-single-cell-atlas-of-an-early-mongolian-sheep-embryo
#35
JOURNAL ARTICLE
Tingyi He, Wenrui Guo, Guang Yang, Hong Su, Aolei Dou, Lu Chen, Teng Ma, Jie Su, Moning Liu, Budeng Su, Wangmei Qi, Haijun Li, Wei Mao, Xiumei Wang, Xihe Li, Yanyan Yang, Yongli Song, Guifang Cao
Cell types have been established during organogenesis based on early mouse embryos. However, our understanding of cell types and molecular mechanisms in the early embryo development of Mongolian sheep has been hampered. This study presents the first comprehensive single-cell transcriptomic characterization at E16 in Ujumqin sheep and Hulunbuir short-tailed sheep. Thirteen major cell types were identified at E16 in Ujumqin sheep, and eight major cell types were identified at E16 in Hulunbuir short-tailed sheep...
August 28, 2023: Veterinary Sciences
https://read.qxmd.com/read/37686117/role-of-bacteria-derived-flavins-in-plant-growth-promotion-and-phytochemical-accumulation-in-leafy-vegetables
#36
JOURNAL ARTICLE
Nivethika Ajeethan, Svetlana N Yurgel, Lord Abbey
Sinorhizobium meliloti 1021 bacteria secretes a considerable amount of flavins (FLs) and can form a nitrogen-fixing symbiosis with legumes. This strain is also associated with non-legume plants. However, its role in plant growth promotion (PGP) of non-legumes is not well understood. The present study evaluated the growth and development of lettuce ( Lactuca sativa ) and kale ( Brassica oleracea var. acephala) plants inoculated with S. meliloti 1021 (FL+ ) and its mutant 1021Δ ribBA , with a limited ability to secrete FLs (FL- )...
August 28, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37686049/complete-de-novo-assembly-of-wolbachia-endosymbiont-of-frankliniella-intonsa
#37
JOURNAL ARTICLE
Zhijun Zhang, Jiahui Zhang, Qizhang Chen, Jianyun He, Xiaowei Li, Yunsheng Wang, Yaobin Lu
As an endosymbiont, Wolbachia exerts significant effects on the host, including on reproduction, immunity, and metabolism. However, the study of Wolbachia in Thysanopteran insects, such as flower thrips Frankliniella intonsa , remains limited. Here, we assembled a gap-free looped genome assembly of Wolbachia strain w FI in a length of 1,463,884 bp (GC content 33.80%), using Nanopore long reads and Illumina short reads. The annotation of w FI identified a total of 1838 protein-coding genes (including 85 pseudogenes), 3 ribosomal RNAs (rRNAs), 35 transfer RNAs (tRNAs), and 1 transfer-messenger RNA (tmRNA)...
August 26, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37678046/a-metal-complex-based-chemosensor-for-the-detection-of-riboflavin-and-folate
#38
JOURNAL ARTICLE
Haobo Xie, Mingu Zhou, Xiaorui Cui, Chao Li, Yongjun Wu, Xinjuan Luo, Mao-Sen Yuan
The vitamins of riboflavin and folate are necessary nutrients for maintaining the proper functioning of human body. Riboflavin and folate deficiency will cause nerve damage, leading to peripheral neuritis, depression, tongue inflammation and other diseases. The sensitive detection of riboflavin and folate keeps its significance for patients and food quality control. In this study, a quinoline-pyridine-combined chemosensor (HQ-TPE) modified by tetraphenylethene was developed. After chelating Cd2+ , the chemosensor exhibited high selectivity and sensitivity for riboflavin and folate...
September 1, 2023: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://read.qxmd.com/read/37639511/facile-strategy-to-output-fluorescein-from-nucleic-acid-interactions
#39
JOURNAL ARTICLE
Yeojin Kim, Sarah Jang, Chuljoo Chang, Ki Tae Kim
Biomolecular operations, which involve the conversion of molecular signals or interactions into specific functional outputs, are fundamental to the field of biology and serve as the important foundation for the design of diagnostic and therapeutic systems. To maximize their functionalities and broaden their applicability, it is crucial to develop novel outputs and facile chemical transformation methods. With this aim, in this study, we present a straightforward method for converting nucleic acid signals into fluorescein outputs that exhibit a wide range of functionalities...
August 28, 2023: Bioconjugate Chemistry
https://read.qxmd.com/read/37629702/in-silico-analysis-of-the-effect-of-hydrastis-canadensis-on-controlling-breast-cancer
#40
JOURNAL ARTICLE
Hima Vyshnavi Am, Sathianarayanan Sankaran, Krishnan Namboori Pk, Baskar Venkidasamy, Abdurahman Hajinur Hirad, Abdullah A Alarfaj, Ramachandran Vinayagam
Background and Objectives: Breast cancer is a significant type of cancer among women worldwide. Studies have reported the anti-carcinogenic activity of Hydrastis Canadensis (Goldenseal) in cancer cell lines. Hydrastis Canadensis could help eliminate toxic substances due to its anti-cancer, anti-inflammatory, and other properties. The design phase includes the identification of potential and effective molecules through modern computational techniques. Objective: This work aims to study Hydrastis Canadensis's effect in controlling hormone-independent breast cancer through in-silico analysis...
August 2, 2023: Medicina
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