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Riboflavin molecular

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https://www.readbyqxmd.com/read/29760960/biochemical-and-molecular-screening-of-varieties-of-chili-plants-that-are-resistant-against-fusarium-wilt-infection
#1
Sobiya Shafique, Shazia Shafique, Aqeel Ahmad
Pakistan holds the position of top chilies producers. So Capsicum annuum L. production in Pakistan should be promoted by combating against diseases. The only solution is to cultivate resistant varieties. Presently six chili varieties were treated with Fusarium oxysporum Schlecht. and screened for the most resistant and the most susceptible varieties. Representative varieties were evaluated for their biochemical and transcriptional profiles to discover the bases of antifungal-resistance. Results concluded that the most resistant variety was "Dandicut" and the most susceptible was "Ghotki"...
April 2018: European Journal of Microbiology & Immunology
https://www.readbyqxmd.com/read/29736707/validation-and-development-of-an-escherichia-coli-riboflavin-pathway-phenotypic-screen-hit-as-a-small-molecule-ligand-of-the-flavin-mononucleotide-riboswitch
#2
Carl J Balibar, Artjohn Villafania, Christopher M Barbieri, Nick Murgolo, Terry Roemer, Hao Wang, John A Howe
A riboflavin biosynthesis pathway-specific phenotypic screen using a library of compounds, all with unspecified antibiotic activity, identified one small molecule later named ribocil, for which intrinsic antibacterial activity against Escherichia coli was completely suppressed by addition of exogenous riboflavin to the bacterial growth medium. The ability of riboflavin to suppress the activity of ribocil, and further demonstration that ribocil inhibited riboflavin synthesis (IC50  = 0.3 μM), supported that a component of the riboflavin synthesis pathway was the molecular target...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29660128/multi-factors-accelerated-aging-of-neutral-pudding-packed-in-retort-pouches-determined-by-instrumental-and-fluorescence-techniques
#3
Anne-Laure Moufle, Julie Jamet, Romdhane Karoui
BACKGROUND: Accelerated shelf life tests have been conducted on very few shelf-stable products. The aim of this study was to reproduce quality changes occurring in neutral pudding packed in retort pouches over a one-year storage period at room temperature in approximately 100 days. The influence of headspace volume, packaging permeability, combination of packaging permeability and light, iron and copper on the quality changes of pudding throughout storage was investigated at the molecular and macroscopic scales...
April 16, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29606427/%C3%AE-and-%C3%AE-casein-aggregation-induced-by-riboflavin-sensitized-photo-oxidation-occurs-via-di-tyrosine-cross-links-and-is-oxygen-concentration-dependent
#4
E Fuentes-Lemus, E Silva, F Leinisch, E Dorta, L G Lorentzen, M J Davies, C López-Alarcón
Type I photo-oxidation generates Trp-(TrpN) and Tyr-derived (TyrO) radicals in proteins which can dimerize producing cross-links, or alternatively react with O2 . It was therefore hypothesized that the O2 concentration may have a significant effect on dye-photosensitized reactions. We studied photo-oxidation of α- and β-caseins induced by riboflavin (RF), a photosensitizing vitamin present in milk, under aerobic and anaerobic conditions. Triplet-state RF induced oxidative modifications on both caseins, and significant levels of cross-links...
August 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29577824/cavitating-leukoencephalopathy-with-posterior-predominance-caused-by-a-deletion-in-the-apopt1-gene-in-an-indian-boy
#5
Suvasini Sharma, Preeti Singh, Erika Fernandez-Vizarra, Massimo Zeviani, Marjo S Van der Knaap, Ravindra Kumar Saran
A 5-year-old Indian boy presented with subacute onset regression of milestones associated with seizures and spasticity. The symptoms started after an attack of measles. The magnetic resonance imaging (MRI) of the brain showed cavitating leukodystrophy with posterior predominance. Molecular analysis of the APOPT1 gene, a recently described gene associated with mitochondrial leukodystrophy, showed the patient to be homozygous for a 12.82-kilobase deletion, including coding exon 3. Deletion of exon 3 produces a frameshift, predicting the translation of a truncated protein (p...
January 1, 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29576618/effects-of-collagen-cross-linking-on-the-keratoconus-metabolic-network
#6
Rabab Sharif, Henrik Sejersen, Garrett Frank, Jesper Hjortdal, Dimitrios Karamichos
PURPOSE: Keratoconus (KC) is a multifactorial, ectatic corneal disease. Metabolic changes in the corneal stroma with alterations in collagen fibril stability, oxidative stress, and urea cycle, have previously been reported as key players in KC pathobiology. Recently, corneal collagen cross-linking (CXL) has been introduced as a treatment that can address the progressive nature of KC. While the treatment has been successful in the early days, it is not without clinical ramifications. In this study, we investigated the alterations in KC metabolic profiles due to CXL...
March 26, 2018: Eye
https://www.readbyqxmd.com/read/29576276/liquid-chromatography-with-alkylammonium-formate-ionic-liquid-mobile-phases-and-fluorescence-detection
#7
Neil D Danielson, Fotouh R Mansour, Ling Zhou, Casey V Connell, Erin M Dotlich, Justin N Gibler, Blake E Norman, Shau Grossman, Wenjun Wei, Ying Zhang
Fluorescence detection of various pharmaceuticals and the amino acid tryptophan (low molecular weight organic compounds) as well as the enzyme lactate dehydrogenase LDH (high molar mass compound) has been studied in aqueous solutions using alkyl ammonium formate ionic liquids as the primary solvent component. It was expected that the high viscosity of such ionic liquid-water mixtures would enhance fluorescence. Pharmaceuticals such as riboflavin and naproxen showed no such enhancement in the presence of ethylammonium formate (EAF) or isopropylammonium formate (IPAF) but the fluorescence of warfarin was substantially enhanced by a factor of 4 with 80% EAF and a factor of 7 with 70% IPAF...
March 14, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29475473/inkjet-printing-based-photo-induced-electron-transfer-reaction-on-parchment-paper-using-riboflavin-as-a-photosensitizer
#8
Annie Agnes Suganya Samson, Jungmi Lee, Joon Myong Song
In this study, we report the photo-induced electron transfer (PET) on parchment paper using riboflavin as a photo inducer and ultraviolet lamp (362 nm) as the light source. To this end, a conventional inkjet printer equipped with 4 cartridges was used. Parchment paper was found to be a favorable substrate due to its insignificant self-absorption while assisting efficient sample interaction. Upon UV-irradiation, riboflavin generated superoxide anion radical (O2 -· ) and it was available to interact with superoxide dismutase present on the same spot...
July 5, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29463319/performance-of-arma-chinensis-reared-on-an-artificial-diet-formulated-using-transcriptomic-methods
#9
D Y Zou, T A Coudron, L S Zhang, X S Gu, W H Xu, X L Liu, H H Wu
An artificial diet formulated for continuous rearing of the predator Arma chinensis was inferior to natural prey when evaluated using life history parameters. A transcriptome analysis identified differentially expressed genes in diet-fed and prey-fed A. chinensis that were suggestive of molecular mechanisms underlying the nutritive impact of the artificial diet. Changes in the diet formulation were made based on the transcriptome analysis and tested using life history parameters. The quantity of pig liver, chicken egg, tuna fish, biotin, nicotinamide, vitamin B6, thiamine, riboflavin, vitamin C, L-glutamine, and sucrose was reduced, and wheat germ oil, calcium pantothenate and folic acid were increased...
February 21, 2018: Bulletin of Entomological Research
https://www.readbyqxmd.com/read/29458205/developing-a-stable-aqueous-enteric-coating-formulation-with-hydroxypropyl-methylcellulose-acetate-succinate-hpmcas-mf-and-colloidal-silicon-dioxide-as-anti-tacking-agent
#10
Tanvi M Deshpande, Anisul Quadir, Sakae Obara, Ahmed Ibrahim, Stephen W Hoag
The purpose of this study was to use statistical design of experiments to develop a stable aqueous enteric coating formulation containing stabilizing excipients, such as polyethylene glycol that can minimize hydroxypropyl methylcellulose acetate succinate aggregation and minimize spray-nozzle clogging at elevated processing temperatures. The mechanisms of stabilization (i.e. charge stabilization and molecular interactions) were studied by performing zeta potential and FTIR studies. Electrostatic stabilization by sodium lauryl sulfate and hydrogen bonding by polyethylene glycol provided dispersion stability and yielded a stable aqueous coating formulation that prevented spray-nozzle clogging...
May 5, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29428966/slc52a3-expression-is-activated-by-nf-%C3%AE%C2%BAb-p65-rel-b-and-serves-as-a-prognostic-biomarker-in-esophageal-cancer
#11
Lin Long, Xiao-Xiao Pang, Fei Lei, Jia-Sheng Zhang, Wei Wang, Lian-Di Liao, Xiu-E Xu, Jian-Zhong He, Jian-Yi Wu, Zhi-Yong Wu, Li-Dong Wang, De-Chen Lin, En-Min Li, Li-Yan Xu
The human riboflavin transporter-3 (encoded by SLC52A3) plays a prominent role in riboflavin absorption. Interestingly, abnormal expression patterns of SLC52A3 in multiple types of human cancers have been recently noted. However, the molecular mechanisms underlying its dysregulation remain unclear. In this study, we find that SLC52A3 has two transcript variants that differ in the transcriptional start site, and encode different proteins: SLC52A3a and SLC52A3b. Importantly, aberrant expressions of SLC52A3 are associated with stepwise development of esophageal squamous cell carcinoma (ESCC) as well as the survival rates of ESCC patients...
February 10, 2018: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29408383/evaluation-of-synergistic-antimicrobial-effect-of-vitamins-a-b1-b2-b6-b12-c-d-e-and-k-with-antibiotics-against-resistant-bacterial-strains
#12
Shakeel Shahzad, M Adnan Ashraf, M Sajid, Aqeel Shahzad, Azhar Rafique, M Shahid Mahmood
BACKGROUND & OBJECTIVES: Multiple drug resistant super bugs of Acinetobacter baumannii and methicillin-resistant Staphylococcus aureus (MRSA) are becoming challenge for healthcare professionals. In this study, vitamins were evaluated for synergistic activity with the antibiotics. METHODS: Synergistic effect between antibiotic and stock solutions of vitamins is evaluated by using Kirby-Bauer disc diffusion assay. Distilled water and propylene glycol were used as solvent for water soluble vitamins and fat-soluble vitamins respectively...
February 2, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29398590/surface-enhanced-raman-scattering-sers-of-riboflavin-on-nanostructured-ag-surfaces-the-role-of-excitation-wavelength-plasmon-resonance-and-molecular-resonance
#13
Martin Šubr, Anna Kuzminova, Ondřej Kylián, Marek Procházka
Optimization of surface-enhanced Raman scattering (SERS)-based sensors for (bio)analytical applications has received much attention in recent years. For optimum sensitivity, both the nanostructure fabrication process and the choice of the excitation wavelength used with respect to the specific analyte studied are of crucial importance. In this contribution, detailed SERS intensity profiles were measured using gradient nanostructures with the localized surface-plasmon resonance (LSPR) condition varying across the sample length and using riboflavin as the model biomolecule...
May 15, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29393543/mucosal-associated-invariant-t-cell-receptor-recognition-of-small-molecules-presented-by-mr1
#14
REVIEW
Wael Awad, Jérôme Le Nours, Lars Kjer-Nielsen, James McCluskey, Jamie Rossjohn
The major histocompatibility complex (MHC) class-I related molecule MR1 is a monomorphic and evolutionary conserved antigen (Ag)-presenting molecule that shares the overall architecture of MHC-I and CD1 proteins. However, in contrast to MHC-I and the CD1 family that present peptides and lipids, respectively, MR1 specifically presents small organic molecules. During microbial infection of mammalian cells, MR1 captures and presents vitamin B precursors, derived from the microbial biosynthesis of riboflavin, on the surface of antigen-presenting cells...
February 2, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29338178/dna-damage-and-apoptosis-induction-in-cancer-cells-by-chemically-engineered-thiolated-riboflavin-gold-nanoassembly
#15
Abhishek Sau, Sulagna Sanyal, Kallol Bera, Sabyasachi Sen, Amrit Krishna Mitra, Uttam Pal, Prabal Kumar Chakraborty, Sayantan Ganguly, Biswarup Satpati, Chandrima Das, Samita Basu
Herein we have engineered a smart nuclear targeting thiol-modified riboflavin-gold nano assembly, RfS@AuNPs, which accumulates selectively in the nucleus without any nuclear-targeting peptides (NLS/RGD) and shows photophysically in vitro DNA intercalation. A theoretical model using Molecular Dynamics has been developed to probe the mechanism of formation and stability as well as dynamics of the RfS@AuNPs in aqueous solution and within the DNA microenvironment. The RfS@AuNPs facilitate the binucleated cell formation that is reflected in the significant increase of DNA damage marker, γ-H2AX as well as the arrest of most of the HeLa cells at the pre-G1 phase indicating cell death...
February 7, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29322794/integrated-analysis-of-the-rna-seq-data-of-liver-hepatocellular-carcinoma
#16
H Xue, L Luo, Y T Yao, L L Wei, S P Deng, X L Huang
The present study aimed to explore the genetic changes involved in the liver hepatocellular carcinoma (HCC) development. The RNA-Seq data of 212 HCC tissue samples and 50 normal tissue samples were downloaded using TCGA-Assembler. A total of 4 subgroups were obtained, and 4167, 6279, 5379, and 2548 DEGs were screened in group 1, group 2, group 3, and group 4, respectively. Enrichment analysis found that cell cycle, metabolism, and translation related terms were the most significantly changed functions and pathways...
2018: Neoplasma
https://www.readbyqxmd.com/read/29299926/hydrophilic-multitemplate-molecularly-imprinted-biopolymers-based-on-a-green-synthesis-strategy-for-determination-of-b-family-vitamins
#17
Abbas Ostovan, Mehrorang Ghaedi, Maryam Arabi, Qian Yang, Jinhua Li, Lingxin Chen
A novel green synthesis strategy was proposed for preparation of multitemplate molecularly imprinted biopolymers (mt-MIBP) in aqueous media with less consumption of organic solvents, which were subsequently used as sorbents of ultrasound-assisted dispersive solid-phase extraction (d-SPE) for simultaneous recognition and efficient separation of B-family vitamins in juice samples, followed by high performance liquid chromatography (HPLC) determination. The obtained mt-MIBP was fully characterized by SEM, FT-IR, TEM, and BET...
January 31, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29277443/priming-plant-resistance-by-activation-of-redox-sensitive-genes
#18
REVIEW
Carmen González-Bosch
Priming by natural compounds is an interesting alternative for sustainable agriculture, which also contributes to explore the molecular mechanisms associated with stress tolerance. Although hosts and stress types eventually determine the mode of action of plant-priming agents, it highlights that many of them act on redox signalling. These include vitamins thiamine, riboflavin and quercetin; organic acids like pipecolic, azelaic and hexanoic; volatile organic compounds such as methyl jasmonate; cell wall components like chitosans and oligogalacturonides; H2 O2 , etc...
December 24, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29242757/differential-gene-transcription-of-extracellular-matrix-components-in-response-to-in-vivo-corneal-crosslinking-cxl-in-rabbit-corneas
#19
Sabine Kling, Arthur Hammer, Emilio A Torres Netto, Farhad Hafezi
Purpose: We studied changes in gene transcription after corneal crosslinking (CXL) in the rabbit cornea in vivo and identified potential molecular signaling pathways. Methods: A total of 15 corneas of eight male New-Zealand-White rabbits were de-epithelialized and equally divided into five groups. Group 1 served as an untreated control. Groups 2 to 5 were soaked with 0.1% riboflavin for 20 minutes, which in Groups 3 to 5 was followed by UV-A irradiation at a fluence of 5...
December 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29212059/on-the-nature-of-solvatochromic-effect-the-riboflavin-absorption-spectrum-as-a-case-study
#20
Isabella Daidone, Andrea Amadei, Massimiliano Aschi, Laura Zanetti-Polzi
We present here the calculation of the absorption spectrum of riboflavin in acetonitrile and dimethyl sulfoxide using a hybrid quantum/classical approach, namely the perturbed matrix method, based on quantum mechanical calculations and molecular dynamics simulations. The calculated spectra are compared to the absorption spectrum of riboflavin previously calculated in water and to the experimental spectra obtained in all three solvents. The experimentally observed variations in the absorption spectra upon change of the solvent environment are well reproduced by the calculated spectra...
March 5, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
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