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Cancer breast margin surgery

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https://www.readbyqxmd.com/read/27906044/high-mammographic-breast-density-predicts-locoregional-recurrence-after-modified-radical-mastectomy-for-invasive-breast-cancer-a-case-control-study
#1
Yu-Sen Huang, Jenny Ling-Yu Chen, Chiun-Sheng Huang, Sung-Hsin Kuo, Fu-Shan Jaw, Yao-Hui Tseng, Wei-Chun Ko, Yeun-Chung Chang
BACKGROUND: We aimed to evaluate the influence of mammographic breast density at diagnosis on the risk of cancer recurrence and survival outcomes in patients with invasive breast cancer after modified radical mastectomy. METHODS: This case-control study included 121 case-control pairs of women diagnosed with invasive breast cancer between 2004 and 2009, and who had undergone modified radical mastectomy and had mammographic breast density measured before or at diagnosis...
December 1, 2016: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/27901301/how-wide-should-margins-be-for-phyllodes-tumors-of-the-breast
#2
Rosemarie Tremblay-LeMay, Jean-Charles Hogue, Louise Provencher, Brigitte Poirier, Éric Poirier, Sophie Laberge, Caroline Diorio, Christine Desbiens
The surgical management of phyllodes tumors (PTs) is still controversial. Some studies have suggested surgical margins ≥1 cm, but recent studies suggested that negative margins could be appropriate regardless of their width. To evaluate recurrence rates of PTs following surgery according to margins. Retrospective study of women who attended a tertiary breast cancer reference center between 1998 and 2010: 142 patients with a PT diagnosis, either at minimally invasive breast biopsy or at surgery, were identified...
November 30, 2016: Breast Journal
https://www.readbyqxmd.com/read/27900632/breast-conserving-surgery-alone-for-ductal-carcinoma-in-situ-factors-associated-with-increased-risk-of-local-recurrence
#3
Alessandra Mele, Pritesh Mehta, Priscilla J Slanetz, Alexander Brook, Abram Recht, Ranjna Sharma
PURPOSE: This retrospective study was aimed at identifying clinicopathologic characteristics associated with an increased risk for ipsilateral local recurrence (LR) in patients with ductal carcinoma in situ (DCIS) treated with wide local excision (WLE) alone without radiotherapy (RT). METHODS: All patients with DCIS treated with WLE alone at the Beth Israel Deaconess Medical Center, Boston, MA, USA, between the years 2000 and 2010 were identified. We collected data on demographics, parity, personal or family history of breast cancer, exogenous hormone use, tobacco use, comorbidities, genetic mutation carrier status, imaging interval, and tumor-specific characteristics...
November 29, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27894703/over-surgery-in-breast-cancer
#4
Fiona MacNeill, Andreas Karakatsanis
Breast surgery remains the original and most effective 'targeted' therapy: excision of early cancer is curative and for more advanced disease surgery improves local disease control. However in well intentioned pursuit of cure and local disease control, some cancers are over-treated resulting in major physical and emotional morbidity. Less breast surgery is safe, as evidenced by steady reductions in mortality and local recurrence; earlier diagnosis and widespread use of systemic therapies and radiotherapy have allowed more conservative surgery...
November 25, 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27885679/clinical-auditing-as-an-instrument-for-quality-improvement-in-breast-cancer-care-in-the-netherlands-the-national-nabon-breast-cancer-audit
#5
Annelotte C M van Bommel, Pauline E R Spronk, Marie-Jeanne T F D Vrancken Peeters, Agnes Jager, Marc Lobbes, John H Maduro, Marc A M Mureau, Kay Schreuder, Carolien H Smorenburg, Janneke Verloop, Pieter J Westenend, Michel W J M Wouters, Sabine Siesling, Vivianne C G Tjan-Heijnen, Thijs van Dalen
BACKGROUND: In 2011, the NABON Breast Cancer Audit (NBCA) was instituted as a nation-wide audit to address quality of breast cancer care and guideline adherence in the Netherlands. The development of the NBCA and the results of 4 years of auditing are described. METHODS: Clinical and pathological characteristics of patients diagnosed with invasive breast cancer or in situ carcinoma (DCIS) and information regarding diagnosis and treatment are collected in all hospitals (n = 92) in the Netherlands...
November 25, 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27882469/influence-of-the-sso-astro-margin-reexcision-guidelines-on-costs-associated-with-breast-conserving-surgery
#6
C R Baliski, R E Pataky
BACKGROUND: The reported reexcision rates vary significantly for patients with invasive breast cancer undergoing breast-conserving surgery (BCS). This variability is a function of both the positive pathologic margin rate and the interpretation of an adequate pathologic margin. The influence of the SSO/ASTRO margin guidelines on reexcision rates and the potential cost savings is of interest from both quality and health economics perspectives. METHODS: A retrospective analysis of all patients undergoing BCS during a 3-year period (January 1, 2010-December 31, 2012) was performed...
November 23, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27872528/evaluation-of-surgical-outcomes-of-oncoplasty-breast-surgery-in-locally-advanced-breast-cancer-and-comparison-with-conventional-breast-conservation-surgery
#7
Ashutosh Chauhan, Mala Mathur Sharma, Kishore Kumar
The purpose of this study was to compare early oncologic outcomes of oncoplastic breast surgery and conventional breast conservation surgery in patients of locally advanced breast cancer. A single-center, prospective, non-randomized study enrolled select cases of locally advanced breast cancer (TNM T3/T4, N0/1/2) who after neoadjuvant chemotherapy, were considered for breast conservation surgery with oncoplasty techniques. The specimen volume resected, the mean margins and mean closest margin obtained were noted...
December 2016: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27867721/wide-field-optical-coherence-micro-elastography-for-intraoperative-assessment-of-human-breast-cancer-margins
#8
Wes M Allen, Lixin Chin, Philip Wijesinghe, Rodney W Kirk, Bruce Latham, David D Sampson, Christobel M Saunders, Brendan F Kennedy
Incomplete excision of malignant tissue is a major issue in breast-conserving surgery, with typically 20 - 30% of cases requiring a second surgical procedure arising from postoperative detection of an involved margin. We report advances in the development of a new intraoperative tool, optical coherence micro-elastography, for the assessment of tumor margins on the micro-scale. We demonstrate an important step by conducting whole specimen imaging in intraoperative time frames with a wide-field scanning system acquiring mosaicked elastograms with overall dimensions of ~50 × 50 mm, large enough to image an entire face of most lumpectomy specimens...
October 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27861746/effect-of-hospital-volume-on-processes-of-breast-cancer-care-a-national-cancer-data-base-study
#9
Tina W F Yen, Liliana E Pezzin, Jianing Li, Rodney Sparapani, Purushuttom W Laud, Ann B Nattinger
BACKGROUND: The purpose of this study was to examine variations in delivery of several breast cancer processes of care that are correlated with lower mortality and disease recurrence, and to determine the extent to which hospital volume explains this variation. METHODS: Women who were diagnosed with stage I-III unilateral breast cancer between 2007 and 2011 were identified within the National Cancer Database. Multiple logistic regression models were developed to determine whether hospital volume was independently associated with each of 10 individual process of care measures addressing diagnosis and treatment, and 2 composite measures assessing appropriateness of systemic treatment (chemotherapy and hormonal therapy) and locoregional treatment (margin status and radiation therapy)...
November 8, 2016: Cancer
https://www.readbyqxmd.com/read/27857263/the-marginprobe%C3%A2-system-an-innovative-approach-to-reduce-the-incidence-of-positive-margins-found-after-lumpectomy
#10
Sowsina Gola, Susan Doyle-Lindrud
The goal of lumpectomy surgery for breast cancer is to completely remove the tumor and have clear margins, reducing the rates of local recurrence. The MarginProbe® System is a new device that can detect microscopic tumor cells at or close to the margin of the surgical resection intraoperatively, providing the surgeon with the ability to re-excise tissue at the time of surgery, reducing the need for a second surgery to obtain clear margins.
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December 1, 2016: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/27842504/epcam-as-multi-tumour-target-for-near-infrared-fluorescence-guided-surgery
#11
P B A A van Driel, M C Boonstra, H A J M Prevoo, M van de Giessen, T J A Snoeks, Q R J G Tummers, S Keereweer, R A Cordfunke, A Fish, J D H van Eendenburg, B P F Lelieveldt, J Dijkstra, C J H van de Velde, P J K Kuppen, A L Vahrmeijer, C W G M Löwik, C F M Sier
BACKGROUND: Evaluation of resection margins during cancer surgery can be challenging, often resulting in incomplete tumour removal. Fluorescence-guided surgery (FGS) aims to aid the surgeon to visualize tumours and resection margins during surgery. FGS relies on a clinically applicable imaging system in combination with a specific tumour-targeting contrast agent. In this study EpCAM (epithelial cell adhesion molecule) is evaluated as target for FGS in combination with the novel Artemis imaging system...
November 14, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27813225/the-value-of-preoperative-lesion-dedicated-ultrasound-of-breast-cancer-before-conserving-surgery-for-optimizing-margins
#12
Dilek Kösehan, Cenap Dener, Kayıhan Akın, Alper Bozkurt, İsmail Bilgiç, Banu Cakir
To investigate the effect of US performed immediately before breast conserving surgery (BCS) by radiologist accompanied by the surgeon. All patients scheduled for BCS in the last year (group 1, n = 46) were evaluated with US immediately before surgery. About 108 patients (group 2) who were treated with BCS before the study were included as the control group. Tumor size and localization, the distances between tumor-skin and tumor-pectoralis muscle fascia were noted. Re-excision rate due to positive margins was significantly lower in group 1...
November 3, 2016: Breast Journal
https://www.readbyqxmd.com/read/27810132/breast-cancer-recurrence-following-radioguided-seed-localization-and-standard-wire-localization-of-nonpalpable-invasive-and-in-situ-breast-cancers-5-year-follow-up-from-a-randomized-controlled-trial
#13
Filgen Fung, Sylvie D Cornacchi, Michael Reedijk, Nicole Hodgson, Charlie H Goldsmith, David McCready, Gabriela Gohla, Colm Boylan, Peter J Lovrics
BACKGROUND: This study compared 5-year breast cancer (BC) recurrence rates in patients randomized to radioguided seed localization (RSL) or wire localization (WL) for non-palpable BC undergoing breast conserving surgery. METHODS: Chart review of follow-up visits and surveillance imaging was conducted. Data collected included patient and tumour factors, adjuvant therapies and BC recurrence (local recurrence (LR), regional recurrence (RR), and distant metastasis (DM))...
October 20, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27803595/reoperation-costs-in-attempted-breast-conserving-surgery-a-decision-analysis
#14
R E Pataky, C R Baliski
BACKGROUND: Breast-conserving surgery (bcs) is the preferred surgical approach for most patients with early-stage breast cancer. Frequently, concerns arise about the pathologic margin status, resulting in an average reoperation rate of 23% in Canada. No consensus has been reached about the ideal reoperation rate, although 10% has been suggested as a target. Upon undergoing reoperation, many patients choose mastectomy and breast reconstruction, which add to the morbidity and cost of patient care...
October 2016: Current Oncology
https://www.readbyqxmd.com/read/27797262/impact-of-using-intra-operative-ultrasound-guided-breast-conserving-surgery-on-positive-margin-and-re-excision-rates-in-breast-cancer-cases-with-current-sso-astro-guidelines
#15
Somchai Thanasitthichai, Arkom Chaiwerawattana, Oradee Phadhana-Anake
PURPOSE: To review the impact of using intra-operative ultrasound guided breast conserving surgery with frozen sections on nal pathological margin outcome with the current guidelines set forth by the Society of Surgical Oncology (SSO) and the American Society of Surgical Oncology (ASTRO). MATERIALS AND METHODS: A retrospective review including all cases of intra-operative ultrasound guided breast conserving surgery was performed at the National Cancer Institute Thailand between 2013 and 2016...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27788951/magnetic-resonance-image-guided-radiation-therapy-for-external-beam-accelerated-partial-breast-irradiation-evaluation-of-delivered-dose-and-intrafractional-cavity-motion
#16
Sahaja Acharya, Benjamin W Fischer-Valuck, Thomas R Mazur, Austen Curcuru, Karl Sona, Rojano Kashani, Olga Green, Laura Ochoa, Sasa Mutic, Imran Zoberi, H Harold Li, Maria A Thomas
PURPOSE: To use magnetic resonance image guided radiation therapy (MR-IGRT) for accelerated partial-breast irradiation (APBI) to (1) determine intrafractional motion of the breast surgical cavity; and (2) assess delivered dose versus planned dose. METHODS AND MATERIALS: Thirty women with breast cancer (stages 0-I) who underwent breast-conserving surgery were enrolled in a prospective registry evaluating APBI using a 0.35-T MR-IGRT system. Clinical target volume was defined as the surgical cavity plus a 1-cm margin (excluding chest wall, pectoral muscles, and 5 mm from skin)...
November 15, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27784760/magnetic-resonance-imaging-of-breast-cancer-does-the-time-interval-between-biopsy-and-mri-influence-mri-pathology-discordance-in-lesion-sizing
#17
Simone Mennella, Francesco Paparo, Matteo Revelli, Paola Baccini, Lucia Secondini, Stella Barbagallo, Daniele Friedman, Alessandro Garlaschi
BACKGROUND: Breast magnetic resonance imaging (MRI) is more accurate than ultrasound and mammography in estimating local extension of both invasive breast cancer and ductal carcinoma in situ (DCIS) and it is part of a breast cancer patient's preoperative management. PURPOSE: To verify if time interval between breast biopsy and preoperative MRI, lesion margins, and biopsy technique can influence tumor sizing on MRI. MATERIAL AND METHODS: By a database search, we retrospectively identified all women with a newly diagnosed, biopsy-proven, primary breast cancer who underwent MRI before surgery...
October 26, 2016: Acta Radiologica
https://www.readbyqxmd.com/read/27775259/major-clinical-research-advances-in-gynecologic-cancer-in-2015
#18
REVIEW
Dong Hoon Suh, Miseon Kim, Hak Jae Kim, Kyung Hun Lee, Jae Weon Kim
In 2015, fourteen topics were selected as major research advances in gynecologic oncology. For ovarian cancer, high-level evidence for annual screening with multimodal strategy which could reduce ovarian cancer deaths was reported. The best preventive strategies with current status of evidence level were also summarized. Final report of chemotherapy or upfront surgery (CHORUS) trial of neoadjuvant chemotherapy in advanced stage ovarian cancer and individualized therapy based on gene characteristics followed...
November 2016: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27756411/intraoperative-indocyanine-green-fluorescence-guidance-for-excision-of-nonpalpable-breast-cancer
#19
Jintao Liu, Wenbin Guo, Meng Tong
BACKGROUND: Different techniques have been used for the guidance of nonpalpable breast cancer (NBC), but none of them has yet achieved perfect results. The aim of this study was to evaluate the feasibility of indocyanine green (ICG) fluorescence-guided nonpalpable breast cancer lesion excision (IFNLE), to introduce an alternative technique. METHODS: The data about 56 patients with preoperatively diagnosed NBCs operated with the help of intraoperative IFNLE between November of 2010 and September of 2014 were retrospectively analyzed...
October 18, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27743848/impact-of-chemotherapy-on-medium-term-physical-function-and-activity-of-older-breast-cancer-survivors-and-associated-biomarkers
#20
Martine Extermann, Christiaan Leeuwenburgh, Laila Samiian, Marina Sehovic, Jinze Xu, Christopher Cubitt, Paul B Jacobsen, Marco Pahor, Stephen R Grobmyer, Todd M Manini
OBJECTIVE: Chemotherapy is less often prescribed in older individuals due to concerns about post-treatment morbidity and quality of life. We evaluated the physical performance of breast cancer survivors treated with and without adjuvant chemotherapy. MATERIALS AND METHODS: We conducted a case-control study in 56 estrogen receptor positive breast cancer survivors (BCS) on adjuvant aromatase inhibitors 1-2years after definitive surgery. Cases had received adjuvant chemotherapy (n=27; age 70...
October 13, 2016: Journal of Geriatric Oncology
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