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https://www.readbyqxmd.com/read/29774313/echoes-from-the-40-th-annual-san-antonio-breast-cancer-symposium-2017
#1
Bekir Kuru
The Annual San Antonio Symposium was held on 5-9, December, 2017 in San Antonio, Texas, USA (1). As expected, many new studies were presented for the first time at the sessions. The unofficial opening lecture in my point of view was given on locoregional recurrence by Monica Morrow from MSKCC, New York. As always, Morrow's lecture on "Challenges in the surgical management of locoregional recurrence" attracted great interest. The other prominent conferences were given on "Individualizing Management of the Axillary Nodes" by Tari A...
April 2018: European Journal of Breast Health
https://www.readbyqxmd.com/read/29761001/multiscale-nonlinear-microscopy-and-widefield-white-light-imaging-enables-rapid-histological-imaging-of-surgical-specimen-margins
#2
Michael G Giacomelli, Tadayuki Yoshitake, Lucas C Cahill, Hilde Vardeh, Liza M Quintana, Beverly E Faulkner-Jones, Jeff Brooker, James L Connolly, James G Fujimoto
The ability to histologically assess surgical specimens in real-time is a long-standing challenge in cancer surgery, including applications such as breast conserving therapy (BCT). Up to 40% of women treated with BCT for breast cancer require a repeat surgery due to postoperative histological findings of close or positive surgical margins using conventional formalin fixed paraffin embedded histology. Imaging technologies such as nonlinear microscopy (NLM), combined with exogenous fluorophores can rapidly provide virtual H&E imaging of surgical specimens without requiring microtome sectioning, facilitating intraoperative assessment of margin status...
May 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29759643/oncoplastic-breast-surgery-for-the-management-of-ductal-carcinoma-in-situ-dcis-is-it-oncologically-safe-a-retrospective-cohort-analysis
#3
Francesca De Lorenzi, Julien Di Bella, Patrick Maisonneuve, Nicole Rotmensz, Giovanni Corso, Roberto Orecchia, Marco Colleoni, Giovanni Mazzarol, Mario Rietjens, Pietro Loschi, Stefano Marcelli, Paolo Veronesi, Viviana Galimberti
BACKGROUND: Few data exist in literature regarding oncoplastic surgery (ONC) and ductal carcinoma in situ (DCIS). The role of ONC in the treatment of DCIS has not been elucidated yet: no case-control study has yet been published on the issue and no long-term oncologic results are reported. METHODS: Using the European Institute of Oncology (IEO) institutional breast cancer data base we investigated the oncologic safety of ONC for DCIS comparing a consecutive series of 44 patients who have underwent ONC followed by external irradiation for DCIS (Group A-study group) with 375 patients who received conservation alone followed by external irradiation for DCIS (Group B control group) in the same period...
April 24, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29748884/predictors-of-residual-disease-after-breast-conservation-surgery
#4
Lisa J Findlay-Shirras, Oussama Outbih, Charlene N Muzyka, Katie Galloway, Pamela C Hebbard, Maged Nashed
INTRODUCTION: Breast-conserving therapy is the standard of care for early-stage breast cancer. In the era of multimodality therapy, the debate on the value of revision surgery for compromised margins continues, and high re-excision rates persist despite updated guidelines. Our study sought to identify the local re-excision rate for compromised margins after lumpectomy, and identify predictors of residual disease at re-excision. METHODS: This population-based retrospective cohort study included women with breast cancer who underwent a lumpectomy between 2009 and 2012 in Manitoba, with close (≤ 2 mm) or positive margins that led to re-excision...
May 10, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29740104/setup-errors-and-effectiveness-of-optical-laser-3d-surface-imaging-system-sentinel-in-postoperative-radiotherapy-of-breast-cancer
#5
Xiaobo Wei, Mengjiao Liu, Yun Ding, Qilin Li, Changhai Cheng, Xian Zong, Wenming Yin, Jie Chen, Wendong Gu
Breast-conserving surgery (BCS) plus postoperative radiotherapy has become the standard treatment for early-stage breast cancer. The aim of this study was to compare the setup accuracy of optical surface imaging by the Sentinel system with cone-beam computerized tomography (CBCT) imaging currently used in our clinic for patients received BCS. Two optical surface scans were acquired before and immediately after couch movement correction. The correlation between the setup errors as determined by the initial optical surface scan and CBCT was analyzed...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29733019/prognostic-factors-of-treatment-failure-for-early-breast-cancer-after-breast-conserving-surgery
#6
Mohammad Aldaqaf, Eugen Bratucu
Introduction: Breast cancer is the most common cancer in women in developed Western countries and is becoming even more significant in many developing countries. Breast conserving surgery (BCS) has become the gold standard for patients with early breast cancer (EBC) (Stage I, II) with an appropriate patient selection. Important risk factors for treatment failure, include margin status, age, tumour multicentricity and use of radiotherapy and adjuvant hormone therapy. AIM: To establish the prognostic variables for ipsilateral breast tumour recurrence (IBTR) in EBC after BCS and the survival rate...
March 2018: Chirurgia
https://www.readbyqxmd.com/read/29731404/tumor-resection-margin-definitions-in-breast-conserving-surgery-systematic-review-and-meta-analysis-of-the-current-literature
#7
REVIEW
Susan G Brouwer de Koning, Marie-Jeanne T F D Vrancken Peeters, Katarzyna Jóźwiak, Patrick A Bhairosing, Theo J M Ruers
Worldwide, various guidelines recommend what constitutes an adequate margin of excision for invasive breast cancer or for ductal carcinoma-in-situ (DCIS). We evaluated the use of different tumor resection margin guidelines and investigated their impact on positive margin rates (PMR) and reoperation rates (RR). Thirteen guidelines reporting on the extent of a positive margin were reviewed along with 31 studies, published between 2011 and 2016, reporting on a well-defined PMR. Studies were categorized according to the margin definition...
April 13, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29721467/practical-consensus-recommendations-for-tumor-margins-and-breast-conservative-surgery
#8
R Sarin, S P Somsekhar, R Kumar, Gupta Pawan, Jain Sumeet, Jindal Pramoj, Zamre Vaishali, Pasha Firoz, P M Parikh, S Aggarwal, R Koul
My suggestion: There is no difference in survival of breast cancer patients treated with either mastectomy or with breast conservation therapy combined with external beam radiotherapy. A positive margin (s) is an important factor contributing to the increased risk of local recurrence. However, in published literature, there is a lack of consensus on the definition of acceptable margin (s). As a result decision process about need for re-excision after positive margins remains uncrear.
April 2018: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/29709338/omitting-radiotherapy-in-women-%C3%A2-65-years-with-low-risk-early-breast-cancer-after-breast-conserving-surgery-and-adjuvant-endocrine-therapy-is-safe
#9
Åsa Wickberg, Göran Liljegren, Fredrika Killander, Henrik Lindman, Judith Bjöhle, Michael Carlberg, Carl Blomqvist, Johan Ahlgren, Kenneth Villman
PURPOSE: The aim of this study was to verify if radiotherapy (RT) safely can be omitted in older women treated for estrogen-receptor positive early breast cancer with breast-conserving surgery (BCS) and endocrine therapy (ET). PATIENTS AND METHODS: Eligibility criteria were: consecutive patients with age ≥65 years, BCS + sentinel node biopsy, clear margins, unifocal T1N0M0 breast cancer tumor, Elston-Ellis histological grade 1 or 2 and estrogen receptor-positive tumor...
April 13, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29695348/quality-of-life-results-for-accelerated-partial-breast-irradiation-with-interstitial-brachytherapy-versus-whole-breast-irradiation-in-early-breast-cancer-after-breast-conserving-surgery-gec-estro-5-year-results-of-a-randomised-phase-3-trial
#10
Rebekka Schäfer, Vratislav Strnad, Csaba Polgár, Wolfgang Uter, Guido Hildebrandt, Oliver J Ott, Daniela Kauer-Dorner, Hellen Knauerhase, Tibor Major, Jaroslaw Lyczek, Jose Luis Guinot, Jürgen Dunst, Cristina Gutierrez Miguelez, Pavel Slampa, Michael Allgäuer, Kristina Lössl, György Kovács, Arnt-René Fischedick, Rainer Fietkau, Alexandra Resch, Anna Kulik, Leo Arribas, Peter Niehoff, Ferran Guedea, Annika Schlamann, Christine Gall, Bülent Polat
BACKGROUND: Previous results from the GEC-ESTRO trial showed that accelerated partial breast irradiation (APBI) using multicatheter brachytherapy in the treatment of early breast cancer after breast-conserving surgery was non-inferior to whole-breast irradiation in terms of local control and overall survival. Here, we present 5-year results of patient-reported quality of life. METHODS: We did this randomised controlled phase 3 trial at 16 hospitals and medical centres in seven European countries...
April 20, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29694313/paget-s-disease-of-the-male-breast-case-report-and-a-point-of-view-from-actual-literature
#11
M Vergine, A Musella, E Gulotta, F Frusone, Alberto De Luca, F Maceli, A Libia, P Benedetti Panici, M Monti
INTRODUCTION: Paget disease of the nipple in man is a very rare breast cancer, and there are not standard procedures or guidelines. In any cases, a Paget's disease could hide an invasive ductal breast cancer. CASE DESCRIPTION: We report the case of a 77-years old man affected by Alzheimer's disease, who presented to our attention because of an ulcerated palpable mass in the right nipple. A biopsy of the lesion showed "intra-epidermic proliferation of epitelioid cells, associated with linfo-plasmacellular infiltration of superficial dermis, compatible with Paget's disease (pTis)"...
March 2018: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29690864/radiogenic-angiosarcoma-of-the-breast-case-report-and-systematic-review-of-the-literature
#12
Askin Dogan, Peter Kern, Beate Schultheis, Günther Häusler, Günther A Rezniczek, Clemens B Tempfer
BACKGROUND: Radiogenic angiosarcoma of the breast (RASB) is a rare late sequela of local irradiation of the breast or chest wall after breast cancer. The prognosis of women with RASB is poor and there is no standardized therapy for this type of malignancy. CASE PRESENTATION: We present the case of a 54 year old woman with RASB (poorly differentiated angiosarcoma of the left breast; pT1, pNX, M0, L0, V0) and a history of invasive-ductal cancer of the left breast (pT1b, G2, pN0, ER positive, PR positive, HER-2/neu negative) treated in July 2012 with breast-conserving surgery, adjuvant chemotherapy with 6 cycles of epirubicin and cyclophosphamide, adjuvant irradiation of the left breast with 50 Gray, and adjuvant endocrine therapy with an aromatase inhibitor...
April 24, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29678525/close-margins-less-than-2-mm-are-not-associated-with-higher-risks-of-10-year-local-recurrence-and-breast-cancer-mortality-compared-with-negative-margins-in-women-treated-with-breast-conserving-therapy
#13
Susan Tyler, Pauline T Truong, Mary Lesperance, Alan Nichol, Chris Baliski, Rebecca Warburton, Scott Tyldesley
PURPOSE: The 2014 Society of Surgical Oncology-American Society for Radiation Oncology consensus suggested "no ink on tumor" is a sufficient surgical margin for invasive breast cancer treated with breast-conserving surgery (BCS). Whether close margins <2 mm are associated with inferior outcomes remains controversial. This study evaluated 10-year outcomes by margin status in a population-based cohort treated with BCS and adjuvant radiation therapy (RT). METHODS AND MATERIALS: The subjects were 10,863 women with invasive cancer categorized as pT1 to T3, any N, and M0 referred from 2001 to 2011, an era in which the institutional policy was to re-excise close or positive margins, except in select cases...
March 13, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29662528/oncoplastic-surgery-for-the-conservative-treatment-of-breast-cancer-in-per%C3%A3%C2%BA-s-national-cancer-institute
#14
Gonzalo Javier Ziegler Rodriguez, Marcelo Diaz Chavez, Gabriela Guadalupe Calderon Valencia, Jose Manuel Cotrina Concha, Milko Raphael Garces Castre, Raul Mantilla
Background: Oncoplastic surgery for breast cancer (OPS) has been a surgical trend for the past 25 years. In 2012, OPS has been introduced as the standard treatment for a selected group of patients at the National Cancer Institute of Peru (INEN). The aim of this study is to describe our findings. Methods: This is a retrospective and descriptive study that identified demographics, tumour-pathologic features and includes patients solely treated since diagnosis until late follow-up at INEN...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29615195/discussion-of-routine-shave-margins-are-not-necessary-in-early-stage-breast-cancer-treated-with-breast-conserving-surgery
#15
Nathalie Johnson
No abstract text is available yet for this article.
March 20, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29605247/breast-reconstruction-after-breast-conservation-therapy-for-breast-cancer
#16
Filip E F Thiessen, Wiebren A A Tjalma, Thierry Tondu
Conservative breast surgery followed by irradiation, often referred to as Breast conserving therapy (BCT), has replaced modified radical mastectomy for the treatment of early stage invasive breast cancer and ductal carcinoma in situ (DCIS). About 10% to 40% of the patients treated with BCT have poor cosmetic outcome results. Small tumours in large breasts can be successfully treated by lumpectomy and radiotherapy, with good cosmetic outcome. However when the tumour breast ratio is higher, the cosmetic outcome can be very disappointing...
March 27, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29595699/severe-bilateral-isolated-coronary-ostial-lesions-as-a-rare-manifestation-of-radiation-induced-cardiac-disease-a-case-report
#17
Metesh Nalin Acharya, Mohammad El-Diasty, Bastian Schmack, Alexander Weymann, Ashham Mansur, Aron-Frederik Popov
RATIONALE: With advances in contemporary radiotherapy techniques, and as cancer survival improves, severe isolated coronary ostial disease may develop many years following mediastinal radiotherapy, even in the absence of classical cardiovascular risk factors. PATIENT CONCERNS: We describe the case of a 73-year-old woman with previous chest radiotherapy for breast cancer who underwent coronary artery bypass graft surgery for severe bilateral coronary ostial lesions...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29594217/treatment-constraints-for-single-dose-external-beam-preoperative-partial-breast-irradiation-in-early-stage-breast-cancer
#18
Ramona K Charaghvandi, Sua Yoo, Bram van Asselen, Anna Rodrigues, Desirée H J G van den Bongard, Janet K Horton
Background: Following breast-conserving surgery and post-operative 3D-conformal accelerated partial breast irradiation (APBI), suboptimal cosmetic results have been reported. Preoperative radiation delivery to the intact tumor enables better target visualization and treatment volume reduction. Single dose preoperative APBI has the potential to improve toxicity profiles, reduce treatment burden and enable in vivo exploration of breast cancer radiogenomics. Purpose: Develop practical guidelines for single dose external beam preoperative APBI...
October 2017: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29588107/proof-of-concept-study-of-3-d-printed-mold-guided-breast-conserving-surgery-in-breast-cancer-patients
#19
Nanyan Rao, Kai Chen, Qihua Yang, Jinmin Niu
PURPOSE: In this proof-of-concept study, we proposed 3-D-printed mold-guided breast-conserving surgery (BCS) in breast cancer patients. PATIENTS AND METHODS: Pathologically confirmed and eligible breast cancer patients received magnetic resonance imaging examinations before BCS. The information on the shape, size, and location of the tumor relative to the nipple was extracted and analyzed. We used a 3-D printing technique to produce a mold to guide BCS for breast cancer patients...
February 20, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29582632/accuracy-of-specimen-radiography-in-assessing-complete-local-excision-with-breast-conservation-surgery
#20
Saira Naz, Imrana Masroor, Shaista Afzal, Waseem Mirza, Sehrish Butt, Zafar Sajjad, Anwar Ahmad
Objective: The aim of this study was to evaluate the accuracy of “X- ray examination of surgically resected specimen‘‘ in assessing complete local excision (CLE). Materials and Methods: In this retrospective cross sectional study, data were collected for all female breast cancer cases who underwent breast-conserving surgery after needle localization of mammographically visible disease. Males, patients with mammographically invisible disease and cases with benign or inconclusive histopathology, those undergoing modified radical mastectomy and individuals with dense breast parenchyma were excluded...
March 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
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