keyword
MENU ▼
Read by QxMD icon Read
search

Feedforward Inhibition

keyword
https://www.readbyqxmd.com/read/27913590/control-of-spike-transfer-at-hippocampal-mossy-fiber-synapses-in-vivo-by-gabaa-and-gabab-receptor-mediated-inhibition
#1
Stefano Zucca, Marilena Griguoli, Meryl Malézieux, Noëlle Grosjean, Mario Carta, Christophe Mulle
: Despite extensive studies in hippocampal slices and incentive from computational theories, the synaptic mechanisms underlying information transfer at mossy fiber (mf) connections between the dentate gyrus (DG) and CA3 neurons in vivo are still elusive. Here we used an optogenetic approach in mice to selectively target and control the activity of DG granule cells (GCs) while performing whole cell and juxtacellular recordings of CA3 neurons in vivo In CA3 pyramidal cells (PCs), mf-CA3 synaptic responses consisted predominantly of an inhibitory postsynaptic potential (IPSP) at low stimulation frequency (0...
December 2, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27911754/cortical-control-of-spatial-resolution-by-vip-interneurons
#2
Inbal Ayzenshtat, Mahesh Miikael Karnani, Jesse Jackson, Rafael Yuste
: Neuronal tuning, defined by the degree of selectivity to a specific stimulus, is a hallmark of cortical computation. Understanding the role of GABAergic interneurons in shaping cortical tuning is now possible with the ability to manipulate interneuron classes selectively. Here, we show that interneurons expressing vasoactive intestinal polypeptide (VIP(+)) regulate the spatial frequency (SF) tuning of pyramidal neurons in mouse visual cortex. Using two-photon calcium imaging and optogenetic manipulations of VIP(+) cell activity, we found that activating VIP(+) cells elicited a stronger network response to stimuli of higher SFs, whereas suppressing VIP(+) cells resulted in a network response shift toward lower SFs...
November 9, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27909103/habenula-induced-inhibition-of-midbrain-dopamine-neurons-is-diminished-by-lesions-of-the-rostromedial-tegmental-nucleus
#3
P Leon Brown, Heather Palacorolla, Dana Brady, Katelyn Riegger, Greg I Elmer, Paul D Shepard
: Neurons in the lateral habenula (LHb) are transiently activated by aversive events and have been implicated in associative learning. Functional changes associated with tonic and phasic activation of the LHb are often attributed to a corresponding inhibition of midbrain dopamine (DA) neurons. Activation of GABAergic neurons in the rostromedial tegmental nucleus (RMTg), a region that receives dense projections from the LHb and projects strongly to midbrain monoaminergic nuclei, is believed to underlie the transient inhibition of DA neurons attributed to activation of the LHb...
December 1, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27815363/stage-specific-timing-of-the-microrna-regulation-of-lin-28-by-the-heterochronic-gene-lin-14-in-caenorhabditis-elegans
#4
Jennifer Tsialikas, Mitchell A Romens, Allison Abbott, Eric G Moss
In normal development, the order and synchrony of diverse developmental events must be explicitly controlled. In the nematode Caenorhabditis elegans, the timing of larval events is regulated by hierarchy of proteins and microRNAs known as the heterochronic pathway. These regulators are organized in feedforward and feedback interactions to form a robust mechanism for specifying the timing and execution of cell fates at successive stages. One member of this pathway is the RNA binding protein LIN-28, which promotes pluripotency and cell fate decisions in successive stages...
November 4, 2016: Genetics
https://www.readbyqxmd.com/read/27796298/spontaneous-emergence-of-fast-attractor-dynamics-in-a-model-of-developing-primary-visual-cortex
#5
Thomas Miconi, Jeffrey L McKinstry, Gerald M Edelman
Recent evidence suggests that neurons in primary sensory cortex arrange into competitive groups, representing stimuli by their joint activity rather than as independent feature analysers. A possible explanation for these results is that sensory cortex implements attractor dynamics, although this proposal remains controversial. Here we report that fast attractor dynamics emerge naturally in a computational model of a patch of primary visual cortex endowed with realistic plasticity (at both feedforward and lateral synapses) and mutual inhibition...
October 31, 2016: Nature Communications
https://www.readbyqxmd.com/read/27774490/implications-of-visual-attention-phenomena-for-models-of-preferential-choice
#6
Timothy L Mullett, Neil Stewart
We use computational modeling to examine the ability of evidence accumulation models to produce the reaction time (RT) distributions and attentional biases found in behavioral and eye-tracking research. We focus on simulating RTs and attention in binary choice with particular emphasis on whether different models can predict the late onset bias (LOB), commonly found in eye movements during choice (sometimes called the gaze cascade). The first finding is that this bias is predicted by models even when attention is entirely random and independent of the choice process...
October 2016: Decision (Washington)
https://www.readbyqxmd.com/read/27741229/theta-gamma-coding-meets-communication-through-coherence-neuronal-oscillatory-multiplexing-theories-reconciled
#7
Douglas McLelland, Rufin VanRullen
Several theories have been advanced to explain how cross-frequency coupling, the interaction of neuronal oscillations at different frequencies, could enable item multiplexing in neural systems. The communication-through-coherence theory proposes that phase-matching of gamma oscillations between areas enables selective processing of a single item at a time, and a later refinement of the theory includes a theta-frequency oscillation that provides a periodic reset of the system. Alternatively, the theta-gamma neural code theory proposes that a sequence of items is processed, one per gamma cycle, and that this sequence is repeated or updated across theta cycles...
October 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/27725086/an-excitatory-cortical-feedback-loop-gates-retinal-wave-transmission-in-rodent-thalamus
#8
Yasunobu Murata, Matthew T Colonnese
Spontaneous retinal waves are critical for the development of receptive fields in visual thalamus (LGN) and cortex (VC). Despite a detailed understanding of the circuit specializations in retina that generate waves, whether central circuit specializations also exist to control their propagation through visual pathways of the brain is unknown. Here we identify a developmentally transient, corticothalamic amplification of retinal drive to thalamus as a mechanism for retinal wave transmission in the infant rat brain...
October 11, 2016: ELife
https://www.readbyqxmd.com/read/27693625/a-neural-mechanism-of-dynamic-gating-of-task-relevant-information-by-top-down-influence-in-primary-visual-cortex
#9
Akikazu Kamiyama, Kazuhisa Fujita, Yoshiki Kashimori
Visual recognition involves bidirectional information flow, which consists of bottom-up information coding from retina and top-down information coding from higher visual areas. Recent studies have demonstrated the involvement of early visual areas such as primary visual area (V1) in recognition and memory formation. V1 neurons are not passive transformers of sensory inputs but work as adaptive processor, changing their function according to behavioral context. Top-down signals affect tuning property of V1 neurons and contribute to the gating of sensory information relevant to behavior...
September 28, 2016: Bio Systems
https://www.readbyqxmd.com/read/27669144/recruitment-of-inhibition-and-excitation-across-mouse-visual-cortex-depends-on-the-hierarchy-of-interconnecting-areas
#10
Rinaldo David D'Souza, Andrew Max Meier, Pawan Bista, Quanxin Wang, Andreas Burkhalter
Diverse features of sensory stimuli are selectively processed in distinct brain areas. The relative recruitment of inhibitory and excitatory neurons within an area controls the gain of neurons for appropriate stimulus coding. We examined how such a balance of inhibition and excitation is differentially recruited across multiple levels of a cortical hierarchy by mapping the locations and strengths of synaptic inputs to pyramidal and parvalbumin (PV)-expressing neurons in feedforward and feedback pathways interconnecting primary (V1) and two higher visual areas...
September 26, 2016: ELife
https://www.readbyqxmd.com/read/27629713/the-role-of-striatal-feedforward-inhibition-in-the-maintenance-of-absence-seizures
#11
Takafumi Arakaki, Séverine Mahon, Stéphane Charpier, Arthur Leblois, David Hansel
UNLABELLED: Absence seizures are characterized by brief interruptions of conscious experience accompanied by oscillations of activity synchronized across many brain areas. Although the dynamics of the thalamocortical circuits are traditionally thought to underlie absence seizures, converging experimental evidence supports the key involvement of the basal ganglia (BG). In this theoretical work, we argue that the BG are essential for the maintenance of absence seizures. To this end, we combine analytical calculations with numerical simulations to investigate a computational model of the BG-thalamo-cortical network...
September 14, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27625669/analysis-of-network-topologies-underlying-ethylene-growth-response-kinetics
#12
Aaron M Prescott, Forest W McCollough, Bryan L Eldreth, Brad M Binder, Steven M Abel
Most models for ethylene signaling involve a linear pathway. However, measurements of seedling growth kinetics when ethylene is applied and removed have resulted in more complex network models that include coherent feedforward, negative feedback, and positive feedback motifs. The dynamical responses of the proposed networks have not been explored in a quantitative manner. Here, we explore (i) whether any of the proposed models are capable of producing growth-response behaviors consistent with experimental observations and (ii) what mechanistic roles various parts of the network topologies play in ethylene signaling...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27605614/inhibitory-gating-of-basolateral-amygdala-inputs-to-the-prefrontal-cortex
#13
Laura M McGarry, Adam G Carter
UNLABELLED: Interactions between the prefrontal cortex (PFC) and basolateral amygdala (BLA) regulate emotional behaviors. However, a circuit-level understanding of functional connections between these brain regions remains incomplete. The BLA sends prominent glutamatergic projections to the PFC, but the overall influence of these inputs is predominantly inhibitory. Here we combine targeted recordings and optogenetics to examine the synaptic underpinnings of this inhibition in the mouse infralimbic PFC...
September 7, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27602585/human-cytomegalovirus-encoded-chemokine-receptor-us28-activates-the-hif-1%C3%AE-pkm2-axis-in-glioblastoma-cells
#14
Raymond H de Wit, Azra Mujić-Delić, Jeffrey R van Senten, Alberto Fraile-Ramos, Marco Siderius, Martine J Smit
The human cytomegalovirus (HCMV) encoded chemokine receptor US28 promotes tumorigenesis through activation of various proliferative and angiogenic signaling pathways. Upon infection, US28 displays constitutive activity and signals in a G protein-dependent manner, hijacking the host's cellular machinery. In tumor cells, the hypoxia inducible factor-1α/pyruvate kinase M2 (HIF-1α/PKM2) axis plays an important role by supporting proliferation, angiogenesis and reprogramming of energy metabolism. In this study we show that US28 signaling results in activation of the HIF-1α/PKM2 feedforward loop in fibroblasts and glioblastoma cells...
September 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27596931/a-hierarchy-of-timescales-explains-distinct-effects-of-local-inhibition-of-primary-visual-cortex-and-frontal-eye-fields
#15
Luca Cocchi, Martin V Sale, Leonardo L Gollo, Peter T Bell, Vinh T Nguyen, Andrew Zalesky, Michael Breakspear, Jason B Mattingley
Within the primate visual system, areas at lower levels of the cortical hierarchy process basic visual features, whereas those at higher levels, such as the frontal eye fields (FEF), are thought to modulate sensory processes via feedback connections. Despite these functional exchanges during perception, there is little shared activity between early and late visual regions at rest. How interactions emerge between regions encompassing distinct levels of the visual hierarchy remains unknown. Here we combined neuroimaging, non-invasive cortical stimulation and computational modelling to characterize changes in functional interactions across widespread neural networks before and after local inhibition of primary visual cortex or FEF...
2016: ELife
https://www.readbyqxmd.com/read/27556956/rtp801-amplifies-nox-4-dependent-oxidative-stress-induced-by-cigarette-smoke
#16
Daniel Hernández-Saavedra, Linda Sanders, Mario J Perez, Beata Kosmider, Lynelle P Smith, John D Mitchell, Toshinori Yoshida, Rubin M Tuder
Tobacco smoke (TS) causes chronic obstructive pulmonary disease including, chronic bronchitis, emphysema and asthma. Rtp801, an inhibitor of mTORC1, is induced by oxidative stress triggered by TS. Its upregulation drives lung susceptibility to TS injury by means of enhancing inflammation and alveolar destruction. We postulated that Rtp801 is not only increased by reactive oxygen species (ROS) in TS, but it is instrumental in creating a feedforward process leading to amplification of endogenous ROS generation...
August 24, 2016: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/27517089/lsps-optogenetics-to-improve-synaptic-connectivity-mapping-unmasking-the-role-of-basket-cell-mediated-feedforward-inhibition
#17
Julia Brill, Joanna Mattis, Karl Deisseroth, John R Huguenard
Neocortical pyramidal cells (PYRs) receive synaptic inputs from many types of GABAergic interneurons. Connections between parvalbumin (PV)-positive, fast-spiking interneurons ("PV cells") and PYRs are characterized by perisomatic synapses and high-amplitude, short-latency IPSCs. Here, we present novel methods to study the functional influence of PV cells on layer 5 PYRs using optogenetics combined with laser-scanning photostimulation (LSPS). First, we examined the strength and spatial distribution of PV-to-PYR inputs...
July 2016: ENeuro
https://www.readbyqxmd.com/read/27511004/gabab-receptors-tune-cortical-feedback-to-the-olfactory-bulb
#18
Camille Mazo, Gabriel Lepousez, Antoine Nissant, Matthew T Valley, Pierre-Marie Lledo
UNLABELLED: Sensory perception emerges from the confluence of sensory inputs that encode the composition of external environment and top-down feedback that conveys information from higher brain centers. In olfaction, sensory input activity is initially processed in the olfactory bulb (OB), serving as the first central relay before being transferred to the olfactory cortex. In addition, the OB receives dense connectivity from feedback projections, so the OB has the capacity to implement a wide array of sensory neuronal computation...
August 10, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27503008/fragile-x-mental-retardation-protein-knockdown-in-the-developing-xenopus-tadpole-optic-tectum-results-in-enhanced-feedforward-inhibition-and-behavioral-deficits
#19
Torrey L S Truszkowski, Eric J James, Mashfiq Hasan, Tyler J Wishard, Zhenyu Liu, Kara G Pratt, Hollis T Cline, Carlos D Aizenman
BACKGROUND: Fragile X Syndrome is the leading monogenetic cause of autism and most common form of intellectual disability. Previous studies have implicated changes in dendritic spine architecture as the primary result of loss of Fragile X Mental Retardation Protein (FMRP), but recent work has shown that neural proliferation is decreased and cell death is increased with either loss of FMRP or overexpression of FMRP. The purpose of this study was to investigate the effects of loss of FMRP on behavior and cellular activity...
August 8, 2016: Neural Development
https://www.readbyqxmd.com/read/27427462/multimodal-and-site-specific-plasticity-of-amygdala-parvalbumin-interneurons-after-fear-learning
#20
Elizabeth K Lucas, Anita M Jegarl, Hirofumi Morishita, Roger L Clem
Stimulus processing in fear conditioning is constrained by parvalbumin interneurons (PV-INs) through inhibition of principal excitatory neurons. However, the contributions of PV-IN microcircuits to input gating and long-term plasticity in the fear system remain unknown. Here we interrogate synaptic connections between afferent pathways, PV-INs, and principal excitatory neurons in the basolateral amygdala. We find that subnuclei of this region are populated two functionally distinct PV-IN networks. PV-INs in the lateral (LA), but not the basal (BA), amygdala possess complex dendritic arborizations, receive potent excitatory drive, and mediate feedforward inhibition onto principal neurons...
August 3, 2016: Neuron
keyword
keyword
96761
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"