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Feedforward Inhibition

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https://www.readbyqxmd.com/read/29779874/a-gabaergic-feedback-shapes-dopaminergic-input-on-the-drosophila-mushroom-body-to-promote-appetitive-long-term-memory
#1
Alice Pavlowsky, Johann Schor, Pierre-Yves Plaçais, Thomas Preat
Memory consolidation is a crucial step for long-term memory (LTM) storage. However, we still lack a clear picture of how memory consolidation is regulated at the neuronal circuit level. Here, we took advantage of the well-described anatomy of the Drosophila olfactory memory center, the mushroom body (MB), to address this question in the context of appetitive LTM. The MB lobes, which are made by the fascicled axons of the MB intrinsic neurons, are organized into discrete anatomical modules, each covered by the terminals of a defined type of dopaminergic neuron (DAN) and the dendrites of a corresponding type of MB output neuron (MBON)...
May 9, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29755493/dynamic-modeling-of-indole-glucosinolate-hydrolysis-and-its-impact-on-auxin-signaling
#2
Daniel Vik, Namiko Mitarai, Nikolai Wulff, Barbara A Halkier, Meike Burow
Plants release chemicals to deter attackers. Arabidopsis thaliana relies on multiple defense compounds, including indol-3-ylmethyl glucosinolate (I3G), which upon hydrolysis initiated by myrosinase enzymes releases a multitude of bioactive compounds, among others, indole-3-acetonitrile and indole-3-acetoisothiocyanate. The highly unstable isothiocyanate rapidly reacts with other molecules. One of the products, indole-3-carbinol, was reported to inhibit auxin signaling through binding to the TIR1 auxin receptor...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29754904/feedforward-inhibition-conveys-time-varying-stimulus-information-in-a-collision-detection-circuit
#3
Hongxia Wang, Richard B Dewell, Ying Zhu, Fabrizio Gabbiani
Feedforward inhibition is ubiquitous as a motif in the organization of neuronal circuits. During sensory information processing, it is traditionally thought to sharpen the responses and temporal tuning of feedforward excitation onto principal neurons. As it often exhibits complex time-varying activation properties, feedforward inhibition could also convey information used by single neurons to implement dendritic computations on sensory stimulus variables. We investigated this possibility in a collision-detecting neuron of the locust optic lobe that receives both feedforward excitation and inhibition...
May 4, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29720550/short-term-plasticity-combines-with-excitation-inhibition-balance-to-expand-cerebellar-purkinje-cell-dynamic-range
#4
Anais Grangeray-Vilmint, Antoine M Valera, Arvind Kumar, Philippe Isope
The balance between excitation (E) and inhibition (I) in neuronal networks controls the firing rate of principal cells through simple network organization, such as feedforward inhibitory circuits. Here, we demonstrate in male mice, that at the granule cell (GrC)-molecular layer interneuron (MLI)-Purkinje cell (PC) pathway of the mouse cerebellar cortex, E/I balance is dynamically controlled by short-term dynamics during bursts of stimuli, shaping cerebellar output. Using a combination of electrophysiological recordings, optogenetic stimulation and modeling, we describe the wide range of bidirectional changes in PC discharge triggered by GrC bursts, from robust excitation to complete inhibition...
May 2, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29682603/feedforward-inhibition-allows-input-summation-to-vary-in-recurrent-cortical-networks
#5
Mark H Histed
Brain computations depend on how neurons transform inputs to spike outputs. Here, to understand input-output transformations in cortical networks, we recorded spiking responses from visual cortex (V1) of awake mice of either sex while pairing sensory stimuli with optogenetic perturbation of excitatory and parvalbumin-positive inhibitory neurons. We found that V1 neurons' average responses were primarily additive (linear). We used a recurrent cortical network model to determine whether these data, as well as past observations of nonlinearity, could be described by a common circuit architecture...
January 2018: ENeuro
https://www.readbyqxmd.com/read/29678876/rapid-disinhibition-by-adjustment-of-pv-intrinsic-excitability-during-whisker-map-plasticity-in-mouse-s1
#6
Melanie A Gainey, Joseph W Aman, Daniel E Feldman
Rapid plasticity of layer (L) 2/3 inhibitory circuits is an early step in sensory cortical map plasticity, but its cellular basis is unclear. We show that, in mice of either sex, 1 day whisker deprivation drives rapid loss of L4-evoked feedforward inhibition and more modest loss of feedforward excitation in L2/3 pyramidal (PYR) cells, increasing E-I conductance ratio. Rapid disinhibition was due to reduced L4-evoked spiking by L2/3 parvalbumin (PV) interneurons, caused by reduced PV intrinsic excitability. This included elevated PV spike threshold, associated with an increase in low-threshold, voltage activated delayed rectifier (presumed Kv1) and A-type potassium currents...
April 20, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29662216/cortical-drive-and-thalamic-feed-forward-inhibition-control-thalamic-output-synchrony-during-absence-seizures
#7
Cian McCafferty, François David, Marcello Venzi, Magor L Lőrincz, Francis Delicata, Zoe Atherton, Gregorio Recchia, Gergely Orban, Régis C Lambert, Giuseppe Di Giovanni, Nathalie Leresche, Vincenzo Crunelli
Behaviorally and pathologically relevant cortico-thalamo-cortical oscillations are driven by diverse interacting cell-intrinsic and synaptic processes. However, the mechanism that gives rise to the paroxysmal oscillations of absence seizures (ASs) remains unknown. Here we report that, during ASs in behaving animals, cortico-thalamic excitation drives thalamic firing by preferentially eliciting tonic rather than T-type Ca 2+ channel (T-channel)-dependent burst firing in thalamocortical (TC) neurons and by temporally framing thalamic output via feedforward reticular thalamic (NRT)-to-TC neuron inhibition...
May 2018: Nature Neuroscience
https://www.readbyqxmd.com/read/29656873/vision-and-locomotion-shape-the-interactions-between-neuron-types-in-mouse-visual-cortex
#8
Mario Dipoppa, Adam Ranson, Michael Krumin, Marius Pachitariu, Matteo Carandini, Kenneth D Harris
Cortical computation arises from the interaction of multiple neuronal types, including pyramidal (Pyr) cells and interneurons expressing Sst, Vip, or Pvalb. To study the circuit underlying such interactions, we imaged these four types of cells in mouse primary visual cortex (V1). Our recordings in darkness were consistent with a "disinhibitory" model in which locomotion activates Vip cells, thus inhibiting Sst cells and disinhibiting Pyr cells. However, the disinhibitory model failed when visual stimuli were present: locomotion increased Sst cell responses to large stimuli and Vip cell responses to small stimuli...
April 11, 2018: Neuron
https://www.readbyqxmd.com/read/29613856/tnf-driven-adaptive-response-mediates-resistance-to-egfr-inhibition-in-lung-cancer
#9
Ke Gong, Gao Guo, David E Gerber, Boning Gao, Michael Peyton, Chun Huang, John D Minna, Kimmo J Hatanpaa, Kemp Kernstine, Ling Cai, Yang Xie, Hong Zhu, Farjana Fattah, Shanrong Zhang, Masaya Takahashi, Bipasha Mukherjee, Sandeep Burma, Jonathan Dowell, Kathryn Dao, Vassiliki A Papadimitrakopoulou, Victor Olivas, Trever G Bivona, Dawen Zhao, Amyn A Habib
Although aberrant Epidermal Growth Factor Receptor (EGFR) signaling is widespread in cancer, EGFR inhibition is effective only in a subset of NSCLC (non-small cell lung cancer) with EGFR activating mutations. A majority of NSCLCs express EGFR wild type (EGFRwt) and do not respond to EGFR inhibition. Tumor necrosis factor (TNF) is a major mediator of inflammation-induced cancer. We find that a rapid increase in TNF level is a universal adaptive response to EGFR inhibition in NSCLC regardless of EGFR status. EGFR signaling actively suppresses TNF mRNA levels by inducing expression of miR-21 resulting in decreased TNF mRNA stability...
April 3, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29572241/contact-dependent-growth-inhibition-induces-high-levels-of-antibiotic-tolerant-persister-cells-in-clonal-bacterial-populations
#10
Anirban Ghosh, Özden Baltekin, Marcus Wäneskog, Dina Elkhalifa, Disa L Hammarlöf, Johan Elf, Sanna Koskiniemi
Bacterial populations can use bet-hedging strategies to cope with rapidly changing environments. One example is non-growing cells in clonal bacterial populations that are able to persist antibiotic treatment. Previous studies suggest that persisters arise in bacterial populations either stochastically through variation in levels of global signalling molecules between individual cells, or in response to various stresses. Here, we show that toxins used in contact-dependent growth inhibition (CDI) create persisters upon direct contact with cells lacking sufficient levels of CdiI immunity protein, which would otherwise bind to and neutralize toxin activity...
March 23, 2018: EMBO Journal
https://www.readbyqxmd.com/read/29570626/angiotensin-ii-induced-mesangial-cell-damaged-is-preceded-by-cell-membrane-permeabilization-due-to-upregulation-of-non-selective-channels
#11
Gonzalo I Gómez, Paola Fernández, Victoria Velarde, Juan C Sáez
Connexin43 (Cx43), pannexin1 (Panx1) and P2X₇ receptor (P2X₇R) are expressed in kidneys and are known to constitute a feedforward mechanism leading to inflammation in other tissues. However, the possible functional relationship between these membrane channels and their role in damaged renal cells remain unknown. In the present work, we found that MES-13 cells, from a cell line derived from mesangial cells, stimulated with angiotensin II (AngII) developed oxidative stress (OS, thiobarbituric acid reactive species (TBARS) and generated pro-inflammatory cytokines (ELISA; IL-1β and TNF-α)...
March 23, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29551963/cannabinoid-receptors-modulate-excitation-of-an-olfactory-bulb-local-circuit-by-cortical-feedback
#12
Frederic Pouille, Nathan E Schoppa
Recent studies have provided evidence that corticofugal feedback (CFF) from the olfactory cortex to the olfactory bulb (OB) can significantly impact the state of excitation of output mitral cells (MCs) and tufted cells (TCs) and also modulate neural synchrony. Interpreting these effects however has been complicated by the large number of cell targets of CFF axons in the bulb. Within the granule cell layer (GCL) alone, CFF axons target both GABAergic granule cells (GCs) as well as GABAergic deep short-axon cells (dSACs) that inhibit GCs...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29547764/feedforward-motor-control-in-developmental-dyslexia-and-developmental-coordination-disorder-does-comorbidity-matter
#13
Fabien Cignetti, Marianne Vaugoyeau, Aurelie Fontan, Marianne Jover, Marie-Odile Livet, Catherine Hugonenq, Frédérique Audic, Brigitte Chabrol, Christine Assaiante
BACKGROUND AND AIM: Feedforward and online controls are two facets of predictive motor control from internal models, which is suspected to be impaired in learning disorders. We examined whether the feedforward component is affected in children (8-12 years) with developmental dyslexia (DD) and/or with developmental coordination disorder (DCD) compared to typically developing (TD) children. METHODS: Children underwent a bimanual unloading paradigm during which a load supported to one arm, the postural arm, was either unexpectedly unloaded by a computer or voluntary unloaded by the subject with the other arm...
May 2018: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29529016/dentate-granule-cell-recruitment-of-feedforward-inhibition-governs-engram-maintenance-and-remote-memory-generalization
#14
Nannan Guo, Marta E Soden, Charlotte Herber, Michael TaeWoo Kim, Antoine Besnard, Paoyan Lin, Xiang Ma, Constance L Cepko, Larry S Zweifel, Amar Sahay
Memories become less precise and generalized over time as memory traces reorganize in hippocampal-cortical networks. Increased time-dependent loss of memory precision is characterized by an overgeneralization of fear in individuals with post-traumatic stress disorder (PTSD) or age-related cognitive impairments. In the hippocampal dentate gyrus (DG), memories are thought to be encoded by so-called 'engram-bearing' dentate granule cells (eDGCs). Here we show, using rodents, that contextual fear conditioning increases connectivity between eDGCs and inhibitory interneurons (INs) in the downstream hippocampal CA3 region...
May 2018: Nature Medicine
https://www.readbyqxmd.com/read/29505572/a-computational-model-for-how-cells-choose-temporal-or-spatial-sensing-during-chemotaxis
#15
Rui Zhen Tan, Keng-Hwee Chiam
Cell size is thought to play an important role in choosing between temporal and spatial sensing in chemotaxis. Large cells are thought to use spatial sensing due to large chemical difference at its ends whereas small cells are incapable of spatial sensing due to rapid homogenization of proteins within the cell. However, small cells have been found to polarize and large cells like sperm cells undergo temporal sensing. Thus, it remains an open question what exactly governs spatial versus temporal sensing. Here, we identify the factors that determines sensing choices through mathematical modeling of chemotactic circuits...
March 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29453207/hippocampal-ripple-oscillations-and-inhibition-first-network-models-frequency-dynamics-and-response-to-gaba-modulators
#16
José R Donoso, Dietmar Schmitz, Nikolaus Maier, Richard Kempter
Hippocampal ripples are involved in memory consolidation, but the mechanisms underlying their generation remain unclear. Models relying on interneuron networks in the CA1 region disagree on the predominant source of excitation to interneurons: either "direct," via the Schaffer collaterals that provide feedforward input from CA3 to CA1, or "indirect," via the local pyramidal cells in CA1, which are embedded in a recurrent excitatory-inhibitory network. Here, we used physiologically constrained computational models of basket-cell networks to investigate how they respond to different conditions of transient, noisy excitation...
March 21, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29425490/fast-spiking-interneurons-supply-feedforward-control-of-bursting-calcium-and-plasticity-for-efficient-learning
#17
Scott F Owen, Joshua D Berke, Anatol C Kreitzer
Fast-spiking interneurons (FSIs) are a prominent class of forebrain GABAergic cells implicated in two seemingly independent network functions: gain control and network plasticity. Little is known, however, about how these roles interact. Here, we use a combination of cell-type-specific ablation, optogenetics, electrophysiology, imaging, and behavior to describe a unified mechanism by which striatal FSIs control burst firing, calcium influx, and synaptic plasticity in neighboring medium spiny projection neurons (MSNs)...
February 8, 2018: Cell
https://www.readbyqxmd.com/read/29420933/precisely-timed-nicotinic-activation-drives-sst-inhibition-in-neocortical-circuits
#18
Joanna Urban-Ciecko, Jean-Sebastien Jouhanneau, Stephanie E Myal, James F A Poulet, Alison L Barth
Sleep, waking, locomotion, and attention are associated with cell-type-specific changes in neocortical activity. The effect of brain state on circuit output requires understanding of how neuromodulators influence specific neuronal classes and their synapses, with normal patterns of neuromodulator release from endogenous sources. We investigated the state-dependent modulation of a ubiquitous feedforward inhibitory motif in mouse sensory cortex, local pyramidal (Pyr) inputs onto somatostatin (SST)-expressing interneurons...
February 7, 2018: Neuron
https://www.readbyqxmd.com/read/29363544/tumor-stroma-il1%C3%AE-irak4-feedforward-circuitry-drives-tumor-fibrosis-chemoresistance-and-poor-prognosis-in-pancreatic-cancer
#19
Daoxiang Zhang, Lin Li, Hongmei Jiang, Qiong Li, Andrea Wang-Gillam, Jinsheng Yu, Richard Head, Jingxia Liu, Marianna B Ruzinova, Kian-Huat Lim
Targeting the desmoplastic stroma of pancreatic ductal adenocarcinoma (PDAC) holds promise to augment the effect of chemotherapy, but success in the clinic has thus far been limited. Preclinical mouse models suggest that near-depletion of cancer-associated fibroblasts (CAF) carries a risk of accelerating PDAC progression, underscoring the need to concurrently target key signaling mechanisms that drive the malignant attributes of both CAF and PDAC cells. We previously reported that inhibition of IL1 receptor-associated kinase 4 (IRAK4) suppresses NFκB activity and promotes response to chemotherapy in PDAC cells...
April 1, 2018: Cancer Research
https://www.readbyqxmd.com/read/29346766/cell-type-specificity-of-callosally-evoked-excitation-and-feedforward-inhibition-in-the-prefrontal-cortex
#20
Paul G Anastasiades, Joseph J Marlin, Adam G Carter
Excitation and inhibition are highly specific in the cortex, with distinct synaptic connections made onto subtypes of projection neurons. The functional consequences of this selective connectivity depend on both synaptic strength and the intrinsic properties of targeted neurons but remain poorly understood. Here, we examine responses to callosal inputs at cortico-cortical (CC) and cortico-thalamic (CT) neurons in layer 5 of mouse prelimbic prefrontal cortex (PFC). We find callosally evoked excitation and feedforward inhibition are much stronger at CT neurons compared to neighboring CC neurons...
January 16, 2018: Cell Reports
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