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Parkinsons bike

C Duchesne, F Gheysen, A Bore, G Albouy, A Nadeau, M E Robillard, F Bobeuf, A L Lafontaine, O Lungu, L Bherer, J Doyon
BACKGROUND: Aerobic exercise training (AET) has been shown to provide general health benefits, and to improve motor behaviours in particular, in individuals with Parkinson's disease (PD). However, the influence of AET on their motor learning capacities, as well as the change in neural substrates mediating this effect remains to be explored. OBJECTIVE: In the current study, we employed functional Magnetic Resonance Imaging (fMRI) to assess the effect of a 3-month AET program on the neural correlates of implicit motor sequence learning (MSL)...
2016: NeuroImage: Clinical
Hassan Mohammadi-Abdar, Angela L Ridgel, Fred M Discenzo, Kenneth A Loparo
Recent studies in rehabilitation of Parkinson's disease (PD) have shown that cycling on a tandem bike at a high pedaling rate can reduce the symptoms of the disease. In this research, a smart motorized bicycle has been designed and built for assisting Parkinson's patients with exercise to improve motor function. The exercise bike can accurately control the rider's experience at an accelerated pedaling rate while capturing real-time test data. Here, the design and development of the electronics and hardware as well as the software and control algorithms are presented...
June 2016: IEEE/ASME Transactions on Mechatronics
Hassan Mohammadi Abdar, Angela Ridgel, Fred Discenzo, Robert Phillips, Benjamin Walter, Kenneth Loparo
To assess and validate the Smart Exercise Bike designed for Parkinson's Disease (PD) rehabilitation, forty-seven individuals with PD were randomly assigned to either the static or dynamic cycling group, and completed three sessions of exercise. Heart rate, cadence and power data were captured and recorded for each patient during exercise. Motor function for each subject was assessed with the UPDRS Motor III test before and after the three exercise sessions to evaluate the effect of exercise on functional abilities...
March 31, 2016: IEEE Transactions on Neural Systems and Rehabilitation Engineering
Fiona J Sorrell, Marta Szklarz, Kamal R Abdul Azeez, Jon M Elkins, Stefan Knapp
The highly diverse Numb-associated kinase (NAK) family has been linked to broad cellular functions including receptor-mediated endocytosis, Notch pathway modulation, osteoblast differentiation, and dendrite morphogenesis. Consequently, NAK kinases play a key role in a diverse range of diseases from Parkinson's and prostate cancer to HIV. Due to the plasticity of this kinase family, NAK kinases are often inhibited by approved or investigational drugs and have been associated with side effects, but they are also potential drug targets...
March 1, 2016: Structure
Madeleine E Hackney, Ho Lim Lee, Jessica Battisto, Bruce Crosson, Keith M McGregor
Parkinson's disease is a neurodegenerative disorder that has received considerable attention in allopathic medicine over the past decades. However, it is clear that, to date, pharmacological and surgical interventions do not fully address symptoms of PD and patients' quality of life. As both an alternative therapy and as an adjuvant to conventional approaches, several types of rhythmic movement (e.g., movement strategies, dance, tandem biking, and Tai Chi) have shown improvements to motor symptoms, lower limb control, and postural stability in people with PD (1-6)...
2015: Frontiers in Neurology
C Duchesne, O Lungu, A Nadeau, M E Robillard, A Boré, F Bobeuf, A L Lafontaine, F Gheysen, L Bherer, J Doyon
BACKGROUND: Aerobic exercise training (AET) has been shown to provide health benefits in individuals with Parkinson's disease (PD). However, it is yet unknown to what extent AET also improves cognitive and procedural learning capacities, which ensure an optimal daily functioning. OBJECTIVE: In the current study, we assessed the effects of a 3-month AET program on executive functions (EF), implicit motor sequence learning (MSL) capacity, as well as on different health-related outcome indicators...
October 2015: Brain and Cognition
Ken-Ichi Fujimoto
I asked about the usage of alternative medicine to 300 outpatients with Parkinson's disease. 163 patients (54.3%) had experience with health appliance and 128 patients (42.7%) had experience with supplements. There is no health appliance or supplement whose efficacy for Parkinson's disease is approved publicly. Most of the patients understood it but some patients who purchased the goods believed to be effective in Parkinson's disease. In addition some patients feel affected because the purchase price is abnormally high...
2013: Rinshō Shinkeigaku, Clinical Neurology
Margaret Schenkman, Deborah A Hall, Anna E Barón, Robert S Schwartz, Pamela Mettler, Wendy M Kohrt
BACKGROUND: Exercise confers short-term benefits for individuals with Parkinson disease (PD). OBJECTIVE: The purpose of the study was to compare short- and long-term responses among 2 supervised exercise programs and a home-based control exercise program. DESIGN: The 16-month randomized controlled exercise intervention investigated 3 exercise approaches: flexibility/balance/function exercise (FBF), supervised aerobic exercise (AE), and home-based exercise (control)...
November 2012: Physical Therapy
Angela L Ridgel, Corey A Peacock, Emily J Fickes, Chul-Ho Kim
OBJECTIVES: To develop a rapid cadence cycling intervention (active-assisted cycling [AAC]) using a motorized bike and to examine physiological perimeters during these sessions in individuals with Parkinson's disease (PD). A secondary goal was to examine whether a single session of AAC at a high cadence would promote improvements in tremor and bradykinesia similar to the on medication state. DESIGN: Before-after pilot trial with cross-over. SETTING: University research laboratory...
November 2012: Archives of Physical Medicine and Rehabilitation
Jay L Alberts, Susan M Linder, Amanda L Penko, Mark J Lowe, Micheal Phillips
Forced exercise has resulted in neuroprotective effects and improved motor function in animal studies. These promising results have not yet been translated fully to humans with Parkinson's disease (PD), as traditional exercise interventions have not yielded global improvements in function. A novel forced exercise intervention is described that has resulted in improved motor function and central nervous system function in PD patients.
October 2011: Exercise and Sport Sciences Reviews
Evan L Thacker, Honglei Chen, Alpa V Patel, Marjorie L McCullough, Eugenia E Calle, Michael J Thun, Michael A Schwarzschild, Alberto Ascherio
The purpose of this study was to investigate associations between recreational physical activity and Parkinson's disease (PD) risk. We prospectively followed 143,325 participants in the Cancer Prevention Study II Nutrition Cohort from 1992 to 2001 (mean age at baseline = 63). Recreational physical activity was estimated at baseline from the reported number of hours per week on average spent performing light intensity activities (walking, dancing) and moderate to vigorous intensity activities (jogging/running, lap swimming, tennis/racquetball, bicycling/stationary bike, aerobics/calisthenics)...
January 2008: Movement Disorders: Official Journal of the Movement Disorder Society
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