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pcks9 and LDL-C

Muharrem Akin, Thomas Skripuletz, L Christian Napp, Dominik Berliner, Ibrahim Akin, Arash Haghikia, Elvan Akin, Johann Bauersachs
Statins are the most widely prescribed drugs to reduce serum low density lipoprotein cholesterol (LDL-C) by inhibiting 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase. LDL-C reduction is associated with a decreased risk of atherosclerotic cardiovascular disease (ASCVD), including cardiovascular disease (CVD) and stroke. Statins reduce LDL-C by 30 to 40%, and the combination with other lipid-lowering agents such as ezetimibe leads to a further reduction by 20 to 25%. However, even the combination of these two agents might not be sufficient in high risk patients to require aggressive LDL-C reduction...
July 27, 2016: Cardiovascular & Hematological Agents in Medicinal Chemistry
Leslie J Donato, Amy K Saenger, Laura J Train, Katrina E Kotzer, Susan A Lagerstedt, Jean M Hornseth, Ananda Basu, Jeffrey L Winters, Linnea M Baudhuin
OBJECTIVE: Familial hypercholesterolemia (FH) can be due to mutations in LDLR, PCSK9, and APOB. In phenotypically defined patients, a subset remains unresponsive to lipid-lowering therapies and requires low density-lipoprotein (LDL) apheresis treatment. In this pilot study, we examined the genotype/phenotype relationship in patients with dyslipidemia undergoing routine LDL apheresis. DESIGN: LDLR, APOB, and PCKS9 were analyzed for disease-causing mutations in seven patients undergoing routine LDL apheresis...
October 2014: Journal of Clinical Apheresis
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