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pneumococcal vaccine adverse effect

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https://www.readbyqxmd.com/read/27887596/effectiveness-immunogenicity-and-safety-of-23-valent-pneumococcal-polysaccharide-vaccine-revaccinations-in-the-elderly-a-systematic-review
#1
Cornelius Remschmidt, Thomas Harder, Ole Wichmann, Christian Bogdan, Gerhard Falkenhorst
BACKGROUND: In many industrialized countries routine vaccination with the 23-valent pneumococcal polysaccharide vaccine (PPSV-23) is recommended to prevent pneumococcal disease in the elderly. However, vaccine-induced immunity wanes after a few years, and there are controversies around revaccination with PPSV-23. Here, we systematically assessed the effectiveness and safety of PPSV-23 revaccination. METHOD: We conducted a systematic literature review in MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials from inception to June 2015...
November 25, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27876197/vaccination-of-special-populations-protecting-the-vulnerable
#2
REVIEW
Mark Doherty, Ruprecht Schmidt-Ott, Jose Ignacio Santos, Lawrence R Stanberry, Annika M Hofstetter, Susan L Rosenthal, Anthony L Cunningham
One of the strategic objectives of the 2011-2020 Global Vaccine Action Plan is for the benefits of immunisation to be equitably extended to all people. This approach encompasses special groups at increased risk of vaccine-preventable diseases, such as preterm infants and pregnant women, as well as those with chronic and immune-compromising medical conditions or at increased risk of disease due to immunosenescence. Despite demonstrations of effectiveness and safety, vaccine uptake in these special groups is frequently lower than expected, even in developed countries with vaccination strategies in place...
November 18, 2016: Vaccine
https://www.readbyqxmd.com/read/27780630/effect-of-tdap-when-administered-before-with-or-after-the-13-valent-pneumococcal-conjugate-vaccine-coadministered-with-the-quadrivalent-meningococcal-conjugate-vaccine-in-adults-a-randomised-controlled-trial
#3
M Tashani, M Alfelali, O Barasheed, A S Alqahtani, L Heron, M Wong, H Rashid, R Booy
Sequential or co-administration of vaccines has potential to alter the immune response to any of the antigens. Existing literature suggests that prior immunisation of tetanus/diphtheria-containing vaccines can either enhance or suppress immune response to conjugate pneumococcal or meningococcal vaccines. We examined this interaction among adult Australian travellers before attending the Hajj pilgrimage 2014. We also investigated tolerability of these vaccines separately and concomitantly. We randomly assigned each participant to one of three vaccination schedules...
October 22, 2016: Vaccine
https://www.readbyqxmd.com/read/27753887/ish-nia-os-02-attenuation-of-hypertension-by-less-invasive-intranasal-vaccination-against-angiotensin-ii-type-1-receptor-in-spontaneously-hypertensive-rats
#4
Tatsuhiko Azegami, Yoshikazu Yuki, Kaori Hayashi, Mari Nakamura, Akihito Hishikawa, Hiroshi Kiyono, Hiroshi Itoh
OBJECTIVE: Previous studies have shown that injectable vaccines against renin-angiotensin system may be effective for the treatment of hypertension, but these injectable vaccines often cause local skin reactions and soreness at the injection site. The aim of this study was to develop a new non-injectable vaccine against angiotensin II type 1 receptor (AT1R) and examine its effect on blood pressure. DESIGN AND METHOD: The peptide, seven-amino-acid sequence from second extracellular loop of rat AT1R was synthesized and then conjugated with pneumococcal surface protein A (PspA) as a carrier protein for the nasal vaccination...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27648207/influenza-and-pneumococcal-vaccination-in-hematological-malignancies-a-systematic-review-of-efficacy-effectiveness-and-safety
#5
REVIEW
Giuseppe La Torre, Alice Mannocci, Vittoria Colamesta, Valeria D'Egidio, Cristina Sestili, Antonietta Spadea
BACKGROUND: The risk of getting influenza and pneumococcal disease is higher in cancer patients, and serum antibody levels tend to be lower in patients with hematological malignancy. OBJECTIVE: To assess flu and pneumococcal vaccinations efficacy, effectiveness, and safety in onco-hematological patients. METHODS: Two systematic reviews and possible meta-analysis were conducted to summarize the results of all primary study in the scientific literature about the flu and pneumococcal vaccine in onco-hematological patients...
2016: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/27643233/ish-nia-os-02-attenuation-of-hypertension-by-less-invasive-intranasal-vaccination-against-angiotensin-ii-type-1-receptor-in-spontaneously-hypertensive-rats
#6
Tatsuhiko Azegami, Yoshikazu Yuki, Kaori Hayashi, Mari Nakamura, Akihito Hishikawa, Hiroshi Kiyono, Hiroshi Itoh
OBJECTIVE: Previous studies have shown that injectable vaccines against renin-angiotensin system may be effective for the treatment of hypertension, but these injectable vaccines often cause local skin reactions and soreness at the injection site. The aim of this study was to develop a new non-injectable vaccine against angiotensin II type 1 receptor (AT1R) and examine its effect on blood pressure. DESIGN AND METHOD: The peptide, seven-amino-acid sequence from second extracellular loop of rat AT1R was synthesized and then conjugated with pneumococcal surface protein A (PspA) as a carrier protein for the nasal vaccination...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27605588/distance-to-health-services-modifies-the-effect-of-an-11-valent-pneumococcal-vaccine-on-pneumonia-risk-among-children-less-than-2-years-of-age-in-bohol-philippines
#7
Elisabeth Dowling Root, Marilla Lucero, Hanna Nohynek, Rebecca Stubbs, Veronica Tallo, Socorro P Lupisan, Diozele M Sanvictores, Leilani T Nillos, Eric A F Simões
BACKGROUND: Both vaccine trials and surveillance studies typically use passive surveillance systems to monitor study outcomes, which may lead to under-reporting of study outcomes in areas with poor access to care. This detection bias can have an adverse effect on conventional estimates of pneumonia risk derived from vaccine trials. METHODS: We conducted a secondary analysis of a randomized, placebo-controlled, double-blind vaccine trial that examined the efficacy of an 11-valent pneumococcal vaccine (PCV) among children less than 2 years of age in Bohol, Philippines...
September 7, 2016: International Journal of Epidemiology
https://www.readbyqxmd.com/read/27576076/optimizing-seroprotection-against-pneumococcus-in-children-with-nephrotic-syndrome-using-the-13-valent-pneumococcal-conjugate-vaccine
#8
Laure F Pittet, Klara M Posfay-Barbe, Hassib Chehade, Christoph Rudin, Alexandra Wilhelm-Bals, Maria Rodriguez, Claire-Anne Siegrist, Paloma Parvex
BACKGROUND: Infections are among the main life-threatening complications in patients with nephrotic syndrome (NS), in particular with Streptococcus pneumoniae, the first cause of bacterial peritonitis and sepsis in these patients. This study aims to evaluate the baseline seroprotection of NS patients against S. pneumoniae, and immunize them with the 13-valent pneumococcal conjugate vaccine (PCV13) regardless of disease activity and previous immunization history, in order to evaluate the immunogenicity, safety profile, and effect of NS treatment on vaccine responses...
September 22, 2016: Vaccine
https://www.readbyqxmd.com/read/27541270/effects-of-prophylactic-ibuprofen-and-paracetamol-administration-on-the-immunogenicity-and-reactogenicity-of-the-10-valent-pneumococcal-non-typeable-haemophilus-influenzae-protein-d-conjugated-vaccine-phid-cv-co-administered-with-dtpa-combined-vaccines-in-children
#9
Oana Falup-Pecurariu, Sorin C Man, Mihai L Neamtu, Gratiana Chicin, Ginel Baciu, Carmen Pitic, Alexandra C Cara, Andrea E Neculau, Marin Burlea, Ileana L Brinza, Cristina N Schnell, Valentina Sas, Valeriu V Lupu, Nancy François, Kristien Swinnen, Dorota Borys
Prophylactic paracetamol administration impacts vaccine immune response; this study ( www.clinicaltrials.gov : NCT01235949) is the first to assess PHiD-CV immunogenicity following prophylactic ibuprofen administration. In this phase IV, multicenter, open-label, randomized, controlled, non-inferiority study in Romania (November 2010-December 2012), healthy infants were randomized 3:3:3:1:1:1 to prophylactically receive immediate, delayed or no ibuprofen (IIBU, DIBU, NIBU) or paracetamol (IPARA, DPARA, NPARA) after each of three primary doses (PHiD-CV at age three/four/five months co-administered with DTPa-HBV-IPV/Hib at three/five and DTPa-IPV/Hib at four months) or booster dose (PHiD-CV and DTPa-HBV-IPV/Hib; 12-15 months)...
August 19, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27155493/immunogenicity-and-safety-of-a-second-administration-of-13-valent-pneumococcal-conjugate-vaccine-5-years-after-initial-vaccination-in-adults-50-years-and-older
#10
Robert W Frenck, Anne Fiquet, Alejandra Gurtman, Martin van Cleeff, Matthew Davis, John Rubino, William Smith, Vani Sundaraiyer, Mohinder Sidhu, Emilio A Emini, William C Gruber, Daniel A Scott, Beate Schmoele-Thoma
BACKGROUND: Vaccination effectively reduces invasive disease and pneumonia caused by Streptococcus pneumoniae. However, waning antibody titers and the ability of revaccination to boost titers in older adults have been concerns. A study to describe antibody persistence after vaccination with 13-valent pneumococcal conjugate vaccine (PCV13) and response to revaccination 5 years after the initial dose was conducted. METHODS: Pneumococcal vaccine-naive subjects aged 50-59 years were randomized and vaccinated with PCV13 plus trivalent inactivated influenza vaccine concomitantly or 1 month apart, then revaccinated with PCV13 five years later...
June 24, 2016: Vaccine
https://www.readbyqxmd.com/read/27149114/safety-and-immunogenicity-of-a-single-dose-23-valent-pneumococcal-polysaccharide-vaccine-in-russian-subjects
#11
Karen Ciprero, Kirill A Zykov, Nikolay I Briko, Tulin Shekar, Tina M Sterling, Elizaveta Bitieva, Jon E Stek, Luwy Musey
: Pneumococcal infection is a major cause of pneumonia, bacteremia, and meningitis. Incidence of pneumococcal disease (PD) varies worldwide. The 23-valent pneumococcal polysaccharide vaccine (PPV23) displays an acceptable safety profile and has been demonstrated cost-effective in reducing burden of PD. METHODS: Approximately 100 subjects from the Russian Federation who were either 2 to 49 y of age with increased risk for PD or ≥50 years of age were enrolled into the study (NCT01734239) to receive a single dose of PPV23 administered intramuscularly...
August 2, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27093162/a-randomized-prospective-study-of-pediatric-patients-with-community-acquired-pneumonia-treated-with-ceftaroline-versus-ceftriaxone
#12
Christopher R Cannavino, Agnes Nemeth, Bartosz Korczowski, John S Bradley, Tanya O'Neal, Alena Jandourek, H David Friedland, Sheldon L Kaplan
BACKGROUND: Community-acquired bacterial pneumonia (CABP) remains a major infection among children, despite the use of pneumococcal vaccination. Ceftaroline fosamil is a broad-spectrum cephalosporin antibiotic with activity against many bacteria, including Streptococcus pneumoniae (both penicillin-nonsusceptible and multidrug-resistant strains) and Staphylococcus aureus (including methicillin-resistant S. aureus). This article describes the safety, tolerability, and effectiveness of ceftaroline fosamil in the treatment of pediatric patients hospitalized with CABP, from a randomized, active-controlled, observer-blinded clinical study (registration number NCT01530763)...
July 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/26793041/onset-of-frozen-shoulder-following-pneumococcal-and-influenza-vaccinations
#13
Zeina M Saleh, Sami Faruqui, Abdullah Foad
OBJECTIVE: Adhesive capsulitis has been suggested as an adverse effect of vaccine administration into the shoulder area. The purpose of this case series is to report 3 cases of acute onset of adhesive capsulitis following pneumococcal and influenza vaccines. CLINICAL FEATURES: Patients reported painful shoulder and limited motion following routine vaccination. After clinical examination, a diagnosis of adhesive capsulitis was noted. INTERVENTION AND OUTCOME: All 3 patients were treated conservatively with physical therapy (active ranges of motion and active-assisted motion), nonsteroidal anti-inflammatory drugs, and activity modification with eventual resolution of symptoms...
December 2015: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/26760593/management-of-sickle-cell-disease-recommendations-from-the-2014-expert-panel-report
#14
Barbara P Yawn, Joylene John-Sowah
Family physicians are the primary and sometimes only health care resource for families affected by sickle cell disease. Recently published guidelines provide important recommendations for health maintenance, acute care, and monitoring of disease-modifying therapy in persons with this condition. This overview highlights some of the most important clinical activities that can and should be carried out in the community care setting. Children with sickle cell anemia should receive prophylactic penicillin from birth through at least five years of age, and all persons with sickle cell disease require vaccination to prevent invasive pneumococcal disease...
December 15, 2015: American Family Physician
https://www.readbyqxmd.com/read/26725745/influenza-and-pneumococcal-vaccine-coverage-in-584-patients-taking-biological-therapy-for-chronic-inflammatory-joint-a-retrospective-study
#15
Olivier Brocq, Emilie Acquacalda, Frédéric Berthier, Christine Albert, Gilles Bolla, Elodie Millasseau, Claire Destombe, Johanna Azulay, Caroline Asquier, Amélie Florent, Sylvie Le Seaux, Liana Euller-Ziegler
OBJECTIVES: To evaluate influenza and pneumococcal vaccine coverage in patients taking biological therapy for chronic inflammatory joint disease and to identify factors associated with the decision to administer these two vaccines. METHODS: Retrospective cross-sectional questionnaire study of a cohort of 584 patients taking biological therapy for chronic inflammatory joint disease (rheumatoid arthritis or spondyloarthritis). We studied the influenza and pneumococcal vaccine coverage rates, information about these vaccines given to patients by the primary-care physician and rheumatologist, and reasons for not administering the vaccines...
March 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/26717361/opsonic-and-antibody-responses-to-pneumococcal-polysaccharide-in-rheumatoid-arthritis-patients-receiving-golimumab-plus-methotrexate
#16
RANDOMIZED CONTROLLED TRIAL
Kiyoshi Migita, Yukihiro Akeda, Manabu Akazawa, Shigeto Tohma, Fuminori Hirano, Haruko Ideguchi, Ryutaro Matsumura, Eiichi Suematsu, Tomoya Miyamura, Shunsuke Mori, Takahiro Fukui, Yasumori Izumi, Nozomi Iwanaga, Yuka Jiuchi, Hideko Kozuru, Hiroshi Tsutani, Kouichirou Saisyo, Takao Yamanaka, Shiro Ohshima, Naoya Mori, Akinori Matsumori, Kiyoki Kitagawa, Koichiro Takahi, Tetsuo Ozawa, Norikazu Hamada, Kyoichi Nakajima, Hideaki Nagai, Norio Tamura, Yasuo Suenaga, Masaharu Kawabata, Toshihiro Matsui, Hiroshi Furukawa, Kenji Kawakami, Kazunori Oishi, Kazunori Oish
Vaccination against Streptococcus pneumoniae is recommended for rheumatoid arthritis (RA) patients receiving immunosuppressive treatments. The objective of this study was to evaluate the humoral response to 23-valent pneumococcal polysaccharide vaccination (PPSV23) in RA patients receiving methotrexate (MTX) alone or in combination with a tumor necrosis factor inhibitor, golimumab (GOM).PPSV23 was given to 114 RA patients, who were classified into three groups: RA control (n = 35), MTX alone (n = 55), and GOM + MTX (n = 24)...
December 2015: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26653668/effect-of-abatacept-on-the-immunogenicity-of-23-valent-pneumococcal-polysaccharide-vaccination-ppsv23-in-rheumatoid-arthritis-patients
#17
RANDOMIZED CONTROLLED TRIAL
Kiyoshi Migita, Yukihiro Akeda, Manabu Akazawa, Shigeto Tohma, Fuminori Hirano, Haruko Ideguchi, Hideko Kozuru, Yuka Jiuchi, Ryutaro Matsumura, Eiichi Suematsu, Tomoya Miyamura, Shunsuke Mori, Takahiro Fukui, Yasumori Izumi, Nozomi Iwanaga, Hiroshi Tsutani, Kouichirou Saisyo, Takao Yamanaka, Shiro Ohshima, Naoya Mori, Akinori Matsumori, Koichiro Takahi, Shigeru Yoshizawa, Yojiro Kawabe, Yasuo Suenaga, Tetsuo Ozawa, Norikazu Hamada, Yasuhiro Komiya, Toshihiro Matsui, Hiroshi Furukawa, Kazunori Oishi
INTRODUCTION: Patients with rheumatoid arthritis (RA) treated with abatacept (ABT) are at increased risk for vaccine-preventable infections. The aim of the present study is to evaluate the humoral response to 23-valent pneumococcal polysaccharide (PPSV23) vaccination in RA patients receiving ABT. METHODS: The immunogenicity study was nested within a randomized, double-blind placebo-controlled study, designed to evaluate the efficacy of the PPSV23. PPSV23 was given to 111 RA patients, who were classified into three groups: RA control (n = 35), methotrexate (MTX) alone (n = 55), and ABT (n = 21)...
2015: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/26651864/effects-of-staffing-and-regional-location-on-influenza-and-pneumococcal-vaccination-rates-in-nursing-home-residents
#18
Erin L Miller, Gregory L Alexander, Richard W Madsen
Vaccinations reduce the risk of hospitalizations and adverse health outcomes in older adult populations, which has led to initiatives such as the Healthy People 2010 goal to vaccinate 90% of all nursing home residents. The current analysis looked at the percentage of residents who received vaccinations in 15,653 nursing homes in the United States and relationships of vaccination to staffing intensity and regional location. Overall, approximately 75% of facilities reached the optimum 90% vaccination levels for long-term residents, but less than 50% reached this goal for short-term residents...
February 2016: Journal of Gerontological Nursing
https://www.readbyqxmd.com/read/26618243/reactogenicity-safety-and-immunogenicity-of-a-protein-based-pneumococcal-vaccine-in-gambian-children-aged-2-4-years-a-phase-ii-randomized-study
#19
A Odutola, M O Ota, E O Ogundare, M Antonio, P Owiafe, A Worwui, B Greenwood, M Alderson, M Traskine, V Verlant, K Dobbelaere, D Borys
Pneumococcal conjugate vaccines (PCVs) have been successful in preventing invasive pneumococcal disease but effectiveness has been challenged by replacement of vaccine serotypes with non-vaccine serotypes. Vaccines targeting common pneumococcal protein(s) found in most/all pneumococci may overcome this limitation. This phase II study assessed safety and immunogenicity of a new protein-based pneumococcal vaccine containing polysaccharide conjugates of 10 pneumococcal serotypes combined with pneumolysin toxoid(dPly) and pneumococcal histidine triad protein D(PhtD) (PHiD-CV/dPly/PhtD-30) in African children...
2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/26615171/vaccine-hesitancy-causes-consequences-and-a-call-to-action
#20
Daniel A Salmon, Matthew Z Dudley, Jason M Glanz, Saad B Omer
Vaccine hesitancy reflects concerns about the decision to vaccinate oneself or one's children. There is a broad range of factors contributing to vaccine hesitancy, including the compulsory nature of vaccines, their coincidental temporal relationships to adverse health outcomes, unfamiliarity with vaccine-preventable diseases, and lack of trust in corporations and public health agencies. Although vaccination is a norm in the U.S. and the majority of parents vaccinate their children, many do so amid concerns...
November 27, 2015: Vaccine
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