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https://www.readbyqxmd.com/read/28520952/defining-optimal-health-range-for-thyroid-function-based-on-the-risk-of-cardiovascular-disease
#1
L Chaker, T I M Korevaar, D Rizopoulos, T-H Collet, H Völzke, A Hofman, N Rodondi, A R Cappola, R P Peeters, O H Franco
Context: Reference ranges of thyroid stimulating hormone (TSH) and free thyroxine (FT4) are defined by their distribution in apparently healthy populations, (2.5th and 97.5th percentiles) irrespective of disease risk and used as cut-offs for defining and clinically managing thyroid dysfunction. Objective: To provide a proof of concept in defining thyroid function optimal health ranges based on cardiovascular disease (CVD) mortality risk. Design and Participants: 9,233 participants from the Rotterdam Study (mean age 65...
May 17, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28500826/serum-kisspeptin-concentrations-are-negatively-correlated-with-body-mass-index-in-adolescents-with-anorexia-nervosa-and-amenorrhea
#2
Flora Bacopoulou, George I Lambrou, Maria-Evangelia Rodanaki, Evgenia Stergioti, Vasiliki Efthymiou, Efthymios Deligeoroglou, Sophia I Markantonis
OBJECTIVE: To measure, for the first time, serum kisspeptin concentrations in adolescent females with anorexia nervosa (AN) and associated amenorrhea, and investigate potential correlations of kisspeptin with anthropometric, bone and hormonal data. DESIGN: Setting: University Adolescent Medicine Center. PARTICIPANTS: Females aged 12-20 years with typical or atypical AN (based on DSM-5 diagnostic criteria) and controls. INTERVENTIONS: Measurement of body mass index (BMI), whole body/lumbar spine bone mineral density and serum concentrations of kisspeptin, follicle stimulating hormone, luteinizing hormone (LH), prolactin (PRL), thyroid stimulating hormone (TSH), free thyroxine, triiodothyronine, estradiol (E2), 17-hydroxyprogesterone...
January 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28494633/comparison-of-in-clinic-point-of-care-and-reference-laboratory-total-thyroxine-immunoassays-for-diagnosis-and-post-treatment-monitoring-of-hyperthyroid-cats
#3
Mark E Peterson, Mark Rishniw, Graham E Bilbrough, Kate B Cote
Objectives The Catalyst One Chemistry Analyzer (IDEXX Laboratories) is a point-of-care instrument that can measure total thyroxine (TT4) by immunoassay. The aims of this study were to evaluate the analytic performance of the Catalyst TT4 assay in feline sera and to examine agreement of the Catalyst TT4 results with those measured by immunoassay at a veterinary reference laboratory. Methods Assay precision, reproducibility and linearity were evaluated for the Catalyst TT4 assay. For method comparison, TT4 concentrations in serum samples from 157 cats (127 hyperthyroid, 30 radioiodine-treated cats) were analyzed by both in-clinic and reference laboratory methods...
May 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28489513/thyroid-function-during-early-life-and-dental-development
#4
S Vucic, T I M Korevaar, B Dhamo, V W V Jaddoe, R P Peeters, E B Wolvius, E M Ongkosuwito
Children with low levels of thyroid hormones (hypothyroidism) have delayed tooth eruption, enamel hypoplasia, micrognathia, and anterior open bite, whereas children with hyperthyroidism may suffer from accelerated tooth eruption, maxillary, and mandibular osteoporosis. However, it is still unknown whether thyroid function variations within the normal or subclinical range also have an impact on hard dental tissues in healthy children. The objective of this study was, therefore, to investigate the association between thyroid function from the fetal period until early childhood and dental development at school age...
May 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28488362/impaired-swim-bladder-inflation-in-early-life-stage-fathead-minnows-exposed-to-a-deiodinase-inhibitor-iopanoic-acid
#5
Jenna E Cavallin, Gerald T Ankley, Brett R Blackwell, Chad A Blanksma, Kellie A Fay, Kathleen M Jensen, Michael D Kahl, Dries Knapen, Patricia A Kosian, Shane Poole, Eric C Randolph, Anthony L Schroeder, Lucia Vergauwen, Daniel L Villeneuve
Inflation of the posterior and/or anterior swim bladder are processes previously demonstrated to be thyroid-hormone regulated. We investigated whether inhibition of deiodinases, which convert thyroxine (T4) to the more biologically-active form, 3,5,3'-triiodothyronine (T3), would impact swim bladder inflation. Two experiments were conducted using a model deiodinase inhibitor, iopanoic acid (IOP). First, fathead minnow embryos were exposed to 0.6, 1.9, or 6.0 mg/L or control water until 6 days post-fertilization (dpf) at which time posterior swim bladder inflation was assessed...
May 10, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28486021/variations-in-serum-free-thyroxin-concentration-within-normal-ranges-predict-the-incidence-of-metabolic-syndrome-in-non-obese-adults-a-cohort-study
#6
Ladan Mehran, Atieh Amouzegar, Mahmood Bakhtiyari, Mohammad Ali Mansournia, Parnian Kheirkhah Rahimabad, Maryam Tohidi, Fereidoun Azizi
BACKGROUND: The association of changes in thyroid hormone values overtime with the incidence of metabolic syndrome (MetS) has not yet been evaluated. This study, for the first time, assessed the effect of thyroid hormone variations in the subclinical and euthyroid range on the incidence of MetS and its components over a 10 year follow-up in an adult population. METHODS: Data were analyzed from the prospective population-based Tehran Thyroid Study. Of 5786 randomly selected subjects, aged ≥20 years, after excluding subjects with MetS (1403), TSH>10 or <0...
May 9, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28482002/thyroid-function-tests-in-the-reference-range-and-fracture-individual-participant-analysis-of-prospective-cohorts
#7
Carole E Aubert, Carmen Floriani, Douglas C Bauer, Bruno R da Costa, Daniel Segna, Manuel R Blum, Tinh-Hai Collet, Howard A Fink, Anne R Cappola, Lamprini Syrogiannouli, Robin P Peeters, Bjørn O Åsvold, Wendy Pj den Elzen, Robert N Luben, Alexandra P Bremner, Apostolos Gogakos, Richard Eastell, Patricia M Kearney, Mari Hoff, Erin Le Blanc, Graziano Ceresini, Fernando Rivadeneira, André G Uitterlinden, Kay-Tee Khaw, Arnulf Langhammer, David J Stott, Rudi Gj Westendorp, Luigi Ferrucci, Graham R Williams, Jacobijn Gussekloo, John P Walsh, Drahomir Aujesky, Nicolas Rodondi
Context: Hyperthyroidism is associated with increased fracture risk, but it is not clear if lower TSH and higher free thyroxine (FT4) in euthyroid individuals are associated with fracture risk. Objective: To evaluate the association of TSH and FT4 with incident fractures in euthyroid individuals. Design: Individual participant data analysis. Setting: Thirteen prospective cohort studies with baseline examinations between 1981 and 2002...
May 5, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28472343/maturation-in-serum-thyroid-function-parameters-over-childhood-and-puberty-results-of-a-longitudinal-study
#8
Peter N Taylor, Adrian Sayers, Onyebuchi Okosieme, Gautam Das, Mohd S Draman, Arshiya Tabasum, Hussam Abusahmin, Mohammad Rahman, Kirsty Stevenson, Alix Groom, Kate Northstone, Wolf Woltersdorf, Andrew Taylor, Susan Ring, John H Lazarus, John W Gregory, Aled Rees, Nicholas Timpson, Colin M Dayan
Context: Serum thyroid hormone levels differ between children and adults, but have not been studied longitudinally in the same individuals through childhood. Objective: To assess changes in thyroid stimulating hormone (TSH) and thyroid hormone levels over childhood and their inter-relationships. Design: Cohort study. Setting: The Avon Longitudinal Study of Parents and Children a population-based birth cohort. Participants: 4,442 children who had thyroid function measured at age 7, and 1,263 children who had thyroid function measured at age 15...
May 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28468867/medication-errors-by-caregivers-at-home-in-neonates-discharged-from-the-neonatal-intensive-care-unit
#9
Ritanshu Solanki, Nivedita Mondal, Thulasingam Mahalakshmy, Vishnu Bhat
OBJECTIVE: To determine the frequency of medication errors by caregivers at home in neonates discharged from the neonatal intensive care unit and to identify the associated risk factors. METHODS: A descriptive, cross-sectional study was conducted in the High Risk Newborn Follow-up Clinic of our institute, on a sample of 166 children, <3 months old. The medications prescribed (syrup preparations of vitamin D, multivitamins, calcium, iron and levetiracetam, tablet L-thyroxine and ursodeoxycholic acid and human milk fortifier powder) were noted from the discharge summary...
May 3, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28468766/regorafenib-induced-hypothyroidism-and-cancer-related-fatigue-is-there-a-potential-link
#10
Fabiana Pani, Matteo Massidda, Valeria Pusceddu, Marco Puzzoni, Elena Massa, Clelia Madeddu, Mario Scartozzi, Stefano Mariotti
OBJECTIVE: Thyroid dysfunction has been reported during Regorafenib (Reg) administration, but no detailed study is presently available. DESIGN: Prospective, observational cohort study. Patients with documented metastatic colorectal cancer and progression of disease during or within 3 months after the last standard therapy, with no evidence and history of previous thyroid disease were enrolled. METHODS: Twenty-five consecutive patients were evaluated before and 8-50 weeks after initiating Reg therapy by monthly clinical, ultrasound and laboratory (thyrotropin [TSH], free thyroxine [fT4], antithyroglobulin [TgAb] and antithyroid peroxidase [TPOAb]) evaluation...
May 3, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28467477/waterborne-exposure-to-bps-causes-thyroid-endocrine-disruption-in-zebrafish-larvae
#11
Dan-Hua Zhang, En-Xiang Zhou, Zhu-Lin Yang
Bisphenol S (BPS) is widely used as a raw material in industry, resulting in its ubiquitous distribution in natural environment, including the aqueous environment. However, the effect of BPS on the thyroid endocrine system is largely unknown. In this study, zebrafish (Danio rerio) embryos were exposed to BPS at 1, 3, 10, and 30 μg/L, from 2 h post-fertilization (hpf) to 168hpf. Bioconcentration of BPS and whole-body thyroid hormones (THs), thyroid-stimulating hormone (TSH) concentrations as well as transcriptional profiling of key genes related to the hypothalamic-pituitary-thyroid (HPT) axis were examined...
2017: PloS One
https://www.readbyqxmd.com/read/28450957/iodine-131-therapy-alters-the-immune-inflammatory-responses-in-the-thyroids-of-patients-with-graves-disease
#12
Wenhua Du, Qingyu Dong, Xiaoting Lu, Xiaomeng Liu, Yueli Wang, Wenxia Li, Zhenyu Pan, Qian Gong, Cuige Liang, Guanqi Gao
The aim of the present study was to evaluate the serum levels of interleukin-6 (IL-6), CXC chemokine ligand-10 (CXCL-10) and intercellular adhesion molecule-l (ICAM-1) in patients with Graves' disease (GD) following iodine-131 ((131)I) therapy. A total of 30 patients with GD participated in the present study. Serum cytokine levels were measured with ELISA, and correlation analyses were performed. Serum levels of IL-6, CXCL-10 and ICAM-1 were significantly higher in patients with GD prior to treatment than those in the control subjects (P<0...
March 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28448064/changes-in-thyroid-hormone-concentrations-during-neonatal-extracorporeal-membrane-oxygenation
#13
L Leeuwen, A F J van Heijst, J van Rosmalen, Y B de Rijke, L W J E Beurskens, D Tibboel, E L T van den Akker, H IJsselstijn
OBJECTIVE: Thyroid hormone concentrations can be disturbed during critical illness. Our aim was to determine changes in thyroid hormone concentrations during neonatal extracorporeal membrane oxygenation (ECMO). STUDY DESIGN: We included 21 ECMO-treated neonates. Age-specific s.d. scores (SDS) of free and total thyroxine (FT4; TT4), reverse and total triiodothyronine (rT3; TT3), thyroid-stimulating hormone (TSH) and thyroxine-binding globulin (TBG) were determined at six fixed time-points...
April 27, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28439924/prevalence-and-predictors-of-thyroid-functional-abnormalities-in-newly-diagnosed-al-amyloidosis
#14
E Muchtar, D S Dean, A Dispenzieri, D Dingli, F K Buadi, M Q Lacy, S R Hayman, P Kapoor, N Leung, S Russell, J A Lust, Yi Lin, R Warsame, W Gonsalves, T V Kourelis, R S Go, R Chakraborty, S Zeldenrust, R A Kyle, S Vincent Rajkumar, S K Kumar, M A Gertz
BACKGROUND: Data on the effect of systemic immunoglobulin light chain amyloidosis (AL amyloidosis) on thyroid function are limited. OBJECTIVE: To assess the prevalence of hypothyroidism in AL amyloidosis patients and determine its predictors. METHODS: 1142 newly diagnosed AL amyloidosis patients were grouped based on the thyroid-stimulating hormone (TSH) measurement at diagnosis: hypothyroid group (TSH above upper normal reference; >5 mIU L(-1) ; n = 217, 19% of study participants) and euthyroid group (n = 925, 81%)...
April 24, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28438338/effects-of-polychlorinated-biphenyls-on-metamorphosis-of-a-marine-fish-japanese-flounder-paralichthys-olivaceus-in-relation-to-thyroid-disruption
#15
Yifei Dong, Xiaona Zhang, Hua Tian, Xiang Li, Wei Wang, Shaoguo Ru
This study examined the influence of environmental concentrations of Aroclor 1254 (10, 100, and 1000ng/L) on metamorphosis of Paralichthys olivaceus, and analyzed the mechanisms in relation to thyroid disruption. Results showed that 100 and 1000ng/L Aroclor 1254 delayed metamorphosis and that 1000ng/L Aroclor 1254 caused abnormal morphology. Thyroxine and triiodothyronine levels in the control group were significantly elevated at metamorphic climax, but treatment with 100 and 1000ng/L delayed the increase in thyroid hormones (THs) and retarded metamorphic processes...
April 21, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28433882/hypothyroidism-following-allogeneic-hematopoietic-stem-cell-transplantation-for-acute-myeloid-leukemia
#16
Michael Medinger, Deborah Zeiter, Dominik Heim, Jörg Halter, Sabine Gerull, André Tichelli, Jakob Passweg, Nicole Nigro
BACKGROUND: Hypothyroidism may complicate allogeneic hematopoietic stem cell transplantation (allo-HSCT); we therefore analyzed risk factors in this study. PATIENTS AND METHODS: We studied 229 patients with acute myeloid leukemia (AML) who underwent an allo-HSCT between 2003 and 2013 with different conditioning regimens (myeloablative, reduced-intensity, chemotherapy-based, or total body irradiation-based). Thyroid-stimulating hormone (TSH) and free thyroxine levels (fT4) were available in 104 patients before and after allo-HSCT...
April 13, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28432797/effects-of-levothyroxine-administration-and-withdrawal-on-the-hypothalamic-pituitary-thyroid-axis-in-euthyroid-dogs
#17
V Ziglioli, D L Panciera, G C Troy, W E Monroe, K M Boes, K R Refsal
BACKGROUND: Chronic supplementation can suppress the hypothalamic-pituitary-thyroid axis (HPTA) and make it difficult to assess thyroid function after withdrawal of levothyroxine. OBJECTIVES: To determine whether the HPTA is suppressed after levothyroxine administration in euthyroid dogs and the time required for resolution of any suppression. ANIMALS: Twenty-eight healthy euthyroid dogs. METHODS: A prospective, randomized study administering levothyroxine to euthyroid dogs for 8 weeks (group 1) or 16 weeks (group 2)...
May 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28429223/sex-related-characteristics-of-systemic-hormonal-homeostasis-in-rats-with-sarcoma-c-45-cells-transplanted-to-the-lung
#18
M B Kozlova, E M Frantsiyants, L K Trepitaki, I V Kaplieva, Yu A Pogorelova, G Z Sergostyants, T G Airapetova, A V Chubaryan
Sex-related systemic status of pituitary and thyroid hormones and cortisol was studied in rats on days 7 and 14 after transplantation of sarcoma C-45 cells into the lung. Females demonstrated slower development of the tumor process (49.0±10.7 vs. 32.0±3.9 days in males). Injection of tumor cells causes similar disorders in the levels of ACTH, thyrotropic hormone, and prolactin in males and females and opposite disorders in the thyroid and glucocorticoid homeostasis associated in males (in contrast to females) with reduction of cortisol level (by 1...
April 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28428677/hypothyroidism-in-pediatric-population-bosnian-and-herzegovinian-situation
#19
Edo Hasanbegovic, Snijezana Hasanbegovic, Edin Begic
INTRODUCTION: Thyroid gland diseases in children are in second place by frequency among all endocrine disorders. When interpreting the results of the thyroid function assessment it should be taken into account the significant differences in the concentrations of TSH, thyroid hormones, thyroid binding proteins and calcitonin among children of different ages. GOAL: To present the age and sex structure of the patients diagnosed with hypothyroidism, evaluate diagnostic methods for making diagnosis, evaluation of etiology of hypothyroidism, with special review of the therapeutic modality...
February 2017: Medical Archives
https://www.readbyqxmd.com/read/28419021/clinical-toxicity-of-acute-overdoses-with-l-thyroxin-in-children
#20
Ayse Betul Ergul, Yasemin Altuner Torun, Mahmut Can Serbetci, Alper Ozcan, Veysel Nijat Bas
OBJECTIVES: L-Thyroxine ingestion is rarely seen in children; here, we report our experience of it. This study describes the clinical characteristics and laboratory findings of acute L-thyroxine ingestion in children. METHODS: This retrospective study enrolled patients treated for L-thyroxine ingestion at Kayseri Teaching Hospital between September 2013 and September 2016. Clinical characteristics and laboratory findings are described. Ethical approval was not obtained because the study was retrospective...
April 18, 2017: Pediatric Emergency Care
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