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https://www.readbyqxmd.com/read/27906195/congenital-hypothyroidism-with-delayed-thyroid-stimulating-hormone-elevation-in-premature-infants-born-at-less-than-30-weeks-gestation
#1
D C Kaluarachchi, T T Colaizy, L M Pesce, M Tansey, J M Klein
OBJECTIVE: Congenital hypothyroidism (CH) with delayed thyroid-stimulating hormone (TSH) elevation is a common form of thyroid dysfunction among premature infants. Routine newborn screening (NBS) may miss infants with CH with delayed TSH elevation. The objective of the study is to determine the prevalence of CH with delayed TSH elevation in premature infants and to identify associated risk factors. STUDY DESIGN: Retrospective analysis of serum thyroid function screening (TFS) at day of life 30 in premature infants <30 weeks gestation, admitted to University of Iowa Neonatal Intensive Care Unit between 1 July 2012 to 30 June 2015...
December 1, 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27905199/high-prevalence-of-anti-tsh-receptor-antibody-in-fibromyalgia-syndrome
#2
Kenya Nishioka, Toyoyoshi Uchida, Chie Usui, Ryota Tanaka, Takashi Matsushima, Yoshifuji Matsumoto, Ikuro Nakamura, Kusuki Nishioka, Nobutaka Hattori
AIM: Fibromyalgia syndrome (FMS) is defined as chronic widespread pain that cannot be accounted for by any other medical disorder. Our aim was to explore the prevalence of thyroid autoimmunity in patients with FMS. METHODS: For determining thyroid function in 207 FMS patients, we tested for the titers of free tri-iodothyronine, free thyroxine, thyroid-stimulating hormone (TSH), anti-thyroid peroxidase antibody (TPOAb), anti-thyroglobulin antibody (TgAb) and anti-TSH receptor antibody (TRAb)...
November 30, 2016: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/27884522/exposure-to-phthalates-in-children-aged-5-7years-associations-with-thyroid-function-and-insulin-like-growth-factors
#3
Wei Wu, Feng Zhou, Yue Wang, Yong Ning, Jian-Ye Yang, Yi-Kai Zhou
This study aimed to evaluate the associations between phthalate concentrations and thyroid function in preschool children. We collected demographic data and biological samples from 216 children aged 5-7years. We calculated urinary concentrations of eight mono-phthalate metabolites (mPAEs) separately for children from urban and rural areas and investigated their associations with thyroid function and growth hormones. mPAE concentrations were higher in children from the urban area than in those from the rural area, and most mPAEs were positively associated with free triiodothyronine and free thyroxine...
November 21, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27883023/a-comparison-of-the-performance-of-molecularly-imprinted-polymer-nanoparticles-for-small-molecule-targets-and-antibodies-in-the-elisa-format
#4
Katarzyna Smolinska-Kempisty, Antonio Guerreiro, Francesco Canfarotta, César Cáceres, Michael J Whitcombe, Sergey Piletsky
Here we show that molecularly imprinted polymer nanoparticles, prepared in aqueous media by solid phase synthesis with immobilised L-thyroxine, glucosamine, fumonisin B2 or biotin as template, can demonstrate comparable or better performance to commercially produced antibodies in enzyme-linked competitive assays. Imprinted nanoparticles-based assays showed detection limits in the pM range and polymer-coated microplates are stable to storage at room temperature for at least 1 month. No response to analyte was detected in control experiments with nanoparticles imprinted with an unrelated template (trypsin) but prepared with the same polymer composition...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27862717/prenatal-diagnosis-and-successful-intrauterine-treatment-of-severe-congenital-hypothyroidism-associated-with-fetal-goiter
#5
Vladimír Ferianec, Peter Papcun, František Grochal, Katarína Schenková, Michaela Bártová
Congenital hypothyroidism with fetal goiter is a rare condition associated with severe, but possibly preventable, intrauterine and postnatal complications. Ultrasound examination after 20 weeks of pregnancy enables prenatal diagnosis and early treatment. Due to limited transplacental transport of thyroid hormones, direct intrauterine treatment is needed. So far, only a few reports of fetal goitrous hypothyroidism have been published and no consensus on adequate management exists. We present a case of severe fetal goitrous hypothyroidism diagnosed at 23 gestational weeks treated by sequential intra-amniotic administration of L-thyroxin...
November 12, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27862211/the-effects-of-intra-hippocampal-l-thyroxine-infusion-on-long-term-potentiation-and-long-term-depression-a-possible-role-for-the-%C3%AE-v%C3%AE-3-integrin-receptor
#6
Soner Bitiktaş, Burak Tan, Şehrazat Kavraal, Marwa Yousef, Yeliz Bayar, Nurcan Dursun, Cem Süer
Although the effects of long-term experimental dysthyroidism on long-term potentiation (LTP) and long-term depression (LTD) have been documented, the relationship between LTP/LTD and acute administration of L-thyroxine (T4) has not been described. Here, we investigated the effects of intra-hippocampal administration of T4 on synaptic plasticity in the dentate gyrus of the hippocampal formation. After a 15-minute baseline recording, LTP and LTD were induced by application of high- and low-frequency stimulation protocols, respectively...
November 10, 2016: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27855294/evidence-for-the-vitamin-d-hypothesis-the-nhanes-iii-extended-mortality-follow-up
#7
Ahmad H Daraghmeh, Monica L Bertoia, Mazen O Al-Qadi, Abdulrahman M Abdulbaki, Mary B Roberts, Charles B Eaton
BACKGROUND AND AIMS: Emerging evidence suggests that low levels of vitamin D may be an important risk factor for multiple chronic diseases and mortality, but the evidence is mixed. Vitamin D levels are associated with sun exposure, diet, and metabolic status. One potential explanation for the lack of consistent findings amongst various studies is that low vitamin levels may be associated with poor diets or other risk factors that we were not adequately controlled for in different analyses...
April 9, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27848196/tablet-and-oral-liquid-l-thyroxine-formulation-in-the-treatment-of-na%C3%A3-ve-hypothyroid-patients-with-helicobacter-pylori-infection
#8
Danilo Ribichini, Giulia Fiorini, Andrea Repaci, Valentina Castelli, Luigi Gatta, Dino Vaira, Renato Pasquali
To compare the clinical efficacy of tablet and oral liquid L-thyroxine (LT4) formulation in naïve hypothyroid subjects with Helicobacter pylori infection. Forty-seven adult naïve hypothyroid subjects with dyspeptic symptoms were investigated with upper endoscopy and divided into: 28 patients with Helicobacter pylori infection (Group A); 15 patients without gastric alterations (group B); 4 patients with autoimmune gastritis were excluded from the study. Subjects were randomly treated with a same dose of LT4 tablet (TAB) or oral liquid formulation (SOL), for 9 months on group A and 6 months on group B...
November 15, 2016: Endocrine
https://www.readbyqxmd.com/read/27832672/tumor-necrosis-factor-%C3%AE-is-inversely-related-to-free-thyroxine-in-euthyroid-subjects-without-diabetes
#9
L J N van Tienhoven-Wind, R P F Dullaart
Lower thyroid functional status within the euthyroid range may confer increased atherosclerosis susceptibility, as evidenced by increased intima media thickness and coronary artery calcification. Associations of lower thyroid functional status with pro-atherogenic (inflammatory) biomarkers may also extend into the euthyroid range. Here we established relationships of plasma tumor necrosis factor-α (TNF-α) with thyroid stimulating hormone (TSH) and free thyroxine (free T4) in euthyroid subjects with and without Type 2 diabetes mellitus (T2DM)...
November 10, 2016: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/27825413/risk-factors-of-lymphnode-metastasis-in-patients-with-thyroid-br-papillary-carcinoma-associated-with-graves-disease
#10
Yong Xie, Yue-Wu Liu, Meng-Yi Wang, Wen-Ze Wang, Hong-Feng Liu, Xiao-Yi Li, Wei-Sheng Gao
Objective To summarize the characteristics of lymph node metastasis in patients with papillary thyroid carcinoma accompanied with Graves disease,and to provide evidence for clinical treatment. Methods Totally 98 patients with papillary thyroid carcinoma and Graves disease who had been treated in Peking Union Medical College Hospital from January 2004 to December 2013 were divided into the lymph node metastasis positive group (n=34) and lymph node metastasis negative group (n=64). The general information,blood biochemical results,pathological results,and prognoses were compared between these two groups...
October 10, 2016: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/27824612/effects-of-altered-thyroid-states-on-oxidative-stress-parameters-in-rats
#11
Sehkar Oktay, Lebriz Uslu, Nesrin Emekli
BACKGROUND: Thyroid hormones are effective on oxidant-antioxidant balance by leading basal metabolic rate. In this study, the effects of altered thyroid states on low density lipoprotein (LDL) oxidation and oxidative stress parameters were investigated in an experimental animal model. METHODS: Thirty female Wistar Albino rats were equally divided into 3 groups as follows: control group; hypothyroid group (methimazole (75 mg/100 g was added to diet); hyperthyroid group [L-thyroxine (0...
November 8, 2016: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27818781/subclinical-hypothyroidism-is-an-independent-predictor-of-adverse-cardiovascular-outcomes-in-patients-with-acute-decompensated-heart-failure
#12
Tomohiro Hayashi, Takuya Hasegawa, Hideaki Kanzaki, Akira Funada, Makoto Amaki, Hiroyuki Takahama, Takahiro Ohara, Yasuo Sugano, Satoshi Yasuda, Hisao Ogawa, Toshihisa Anzai
AIMS: Altered thyroid hormone metabolism characterized by a low triiodothyronine (T3), so-called low-T3 syndrome, is a common finding in patients with severe systemic diseases. Additionally, subclinical thyroid dysfunction, defined as abnormal thyroid stimulating hormone (TSH) and normal thyroxine (T4), causes left ventricular dysfunction. Our objective was to identify the prevalence and prognostic impact of low-T3 syndrome and subclinical thyroid dysfunction in patients with acute decompensated heart failure (ADHF)...
September 2016: ESC Heart Failure
https://www.readbyqxmd.com/read/27818216/estimation-of-iodine-nutrition-and-thyroid-function-status-in-late-gestation-pregnant-women-in-the-united-states-development-and-application-of-a-population-based-pregnancy-model
#13
A Lumen, N I George
Previously, a deterministic biologically-based dose-response (BBDR) pregnancy model was developed to evaluate moderate thyroid axis disturbances with and without thyroid-active chemical exposure in a near-term pregnant woman and fetus. In the current study, the existing BBDR model was adapted to include a wider functional range of iodine nutrition, including more severe iodine deficiency conditions, and to incorporate empirically the effects of homeostatic mechanisms. The extended model was further developed into a population-based model and was constructed using a Monte Carlo-based probabilistic framework...
November 3, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/27816062/using-hashimoto-thyroiditis-as-gold-standard-to-determine-the-upper-limit-value-of-thyroid-stimulating-hormone-in-a-chinese-cohort
#14
Yu Li, Dong-Ning Chen, Jing Cui, Zhong Xin, Guang-Ran Yang, Ming-Jia Niu, Jin-Kui Yang
BACKGROUND: Subclinical hypothyroidism, commonly caused by Hashimoto thyroiditis (HT), is a risk factor for cardiovascular diseases. This disorder is defined as merely having elevated serum thyroid stimulating hormone (TSH) levels. However, the upper limit of reference range for TSH is debated recently. This study was to determine the cutoff value for the upper normal limit of TSH in a cohort using the prevalence of Hashimoto thyroiditis as "gold" calibration standard. METHODS: The research population was medical staff of 2856 individuals who took part in health examination annually...
November 6, 2016: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/27809356/the-effect-of-growth-hormone-replacement-on-the-thyroid-axis-in-patients-with-hypopituitarism-in-vivo-and-ex-vivo-studies
#15
Nigel Glynn, Helena Kenny, Leah Quisenberry, David J Halsall, Paul Cook, Tommy Kyaw Tun, John H McDermott, Diarmuid Smith, Christopher J Thompson, Donal J O'Gorman, Anita Boelen, Joaquin Lado-Abeal, Amar Agha
OBJECTIVE: Alterations in the hypothalamo-pituitary-thyroid axis have been reported following growth hormone (GH) replacement. The aim was examine the relationship between changes in serum concentration of thyroid hormones and deiodinase activity in subcutaneous adipose tissue, before and after GH replacement. DESIGN: A prospective, observational study of patients receiving GH replacement as part of routine clinical care. PATIENTS: Twenty adult hypopituitary men...
November 3, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27793418/omega-3-fatty-acids-decreases-oxidative-stress-tumor-necrosis-factor-alpha-and-interleukin-1-beta-in-hyperthyroidism-induced-hepatic-dysfunction-rat-model
#16
Asmaa M S Gomaa, Ebtihal A Abd El-Aziz
Hyperthyroidism is associated with abnormalities of the liver. Omega-3 polyunsaturated fatty acids, especially their long-chain forms: eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have beneficial health effects. The objectives of the present study were to assess hyperthyroidism-induced hepatic dysfunction in adult male rats and to evaluate the ameliorative effects of omega-3 on hyperthyroidism-induced hepatic dysfunction and the underlying mechanisms. Twenty four adult male rats were randomly divided into three equal groups; control group which received water for 6 weeks, hyperthyroid group which received L-thyroxine orally for 6 weeks and hyperthyroid omega-3 treated group which received L-thyroxine for 2 weeks and then co-treated with L-thyroxine and omega-3 oral compound containing 18% of EPA and 12% of DHA for 4 weeks...
December 2016: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/27793066/potential-influence-of-selenium-copper-zinc-and-cadmium-on-l-thyroxine-substitution-in-patients-with-hashimoto-thyroiditis-and-hypothyroidism
#17
Z Rasic-Milutinovic, D Jovanovic, G Bogdanovic, J Trifunovic, J Mutic
Background: Besides genetic factors, it is known that some trace elements, as Selenium, Copper, and Zinc are essential for thyroid gland fuction and thyroid hormone metabolism. Moreover, there were some metals effect that suggested patterns associated with overt thyroid disease. Aim of study: Hashimoto thyroiditis (HT), chronic autoimune inflamation of thyroid gland with cosequtive hipothyroidism, is common disease in Serbia, and we thought it is worthwile to explore potential effects of essential and toxic metals and metalloides on thyroid function and ability to restore euthyroid status of them...
October 28, 2016: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/27786042/no-effect-of-the-thr92ala-polymorphism-of-deiodinase-2-on-thyroid-hormone-parameters-health-related-quality-of-life-and-cognitive-functioning-in-a-large-population-based-cohort-study
#18
Hanneke J C M Wouters, Hannah Constance Mathilde van Loon, Melanie M Van der Klauw, Martin F Elderson, Sandra N Slagter, Anneke C Muller Kobold, Ido P Kema, Thera P Links, Jana V van Vliet-Ostaptchouk, Bruce H R Wolffenbuttel
INTRODUCTION: The presence of Thr92Ala polymorphism of deiodinase-2 (D2) may have several effects. It may influence its enzymatic function, is associated with increased expression of genes involved in oxidative stress in brain tissue, and may predict favorable response to combination levothyroxine (LT4) plus triiodothyronine (T3) therapy. We hypothesized that homozygous carriers of the D2-92Ala allele have different thyroid hormone parameters, and reduced health-related quality of life (HR-QoL) and cognitive functioning...
October 27, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27780123/life-cycle-exposure-to-bde-47-results-in-thyroid-endocrine-disruption-to-adults-and-offsprings-of-zebrafish-danio-rerio
#19
Xuesong Zhao, Xin Ren, Baixiang Ren, Zhouying Luo, Rong Zhu
2,2,4',4'-Tetrabromodi-phenyl ether (BDE-47) is predominantly concentrated in humans and wildlife and disturbs thyroid hormone homeostasis. The purpose of this study was to characterize the thyroid endocrine disruption induced by life-cycle exposure to BDE-47 in adults and offspring of zebrafish (Danio rerio). We exposed zebrafish embryos at the blastula stage to different concentrations of BDE-47 (1, 5, and 10μg/L). Exposure duration was 180days until fish reached adulthood. In F0 larvae, exposure decreased survival and increased malformations at 4 dpf...
December 2016: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27766119/study-of-optimal-replacement-of-thyroxine-in-the-elderly-sorted-results-from-the-feasibility-randomised-controlled-trial
#20
Salman Razvi, Lorna Ingoe, Vicky Ryan, Simon H S Pearce, Scott Wilkes
BACKGROUND: Hypothyroidism is a common condition, particularly in the older population. Thyroid hormone requirements change with age and serum TSH levels also alter, especially in older patients. However, in practice laboratory reference ranges for thyroid function are not age-specific and treatment in older patients aims to achieve a similar target thyroid function level as younger age groups. METHODS: A dual centre, single blind, randomised controlled trial was conducted to determine the feasibility of a future definitive RCT in hypothyroid individuals aged 80 years or older who were treated with levothyroxine...
2016: Thyroid Research
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