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https://www.readbyqxmd.com/read/29778126/is-parenteral-levothyroxine-therapy-safe-in-intractable-hypothyroidism
#1
Hande Peynirci, Bengur Taskiran, Erdinc Erturk, Pınar Sisman, Canan Ersoy
CASE: A 32-year old woman was admitted to the hospital due to intractable hypothyroidism refractory to high dose of oral l-thyroxine therapy. She underwent total thyroidectomy and radioactive iodine therapy due to papillary thyroid cancer. After excluding poor adherence to therapy and malabsorption, levothyroxine absorption test was performed. No response was detected. Transient neurologic symptoms developed during the test. She developed 3 attacks consisting of neurologic symptoms during high dose administration...
June 2018: Journal of the National Medical Association
https://www.readbyqxmd.com/read/29778090/massive-pericardial-effusion-without-cardiac-tamponade-due-to-subclinical-hypothyroidism-hashimoto-s-disease
#2
Panteleimon E Papakonstantinou, Nikolaos Gourniezakis, Christos Skiadas, Alexandros Patrianakos, Achilleas Gikas
CONTEXT: Hypothyroidism is a significant cause of pericardial effusion. However, large pericardial effusions due to hypothyroidism are extremely rare. Hormone replacement therapy is the cornerstone of treatment for hypothyroidism and regular follow-up of patients after initiation of the therapy is indicated. Herein, the case of a 70-year-old woman with a massive pericardial effusion due to Hashimoto's disease is presented. ISSUES: A 70-year-old female from a rural village on the island of Crete, Greece, was admitted to our hospital due to a urinary tract infection...
May 2018: Rural and Remote Health
https://www.readbyqxmd.com/read/29777516/irisin-levels-increase-after-treatment-in-patients-with-newly-diagnosed-hashimoto-thyroiditis
#3
Z A Uc, S Gorar, S Mizrak, S Gullu
PURPOSE: Irisin is a newly identified myokine secreted by skeletal muscle and has significant effects on body metabolism. Thyroidal functional state has a profound influence on the metabolism of human body. Therefore, the aim of this study was to investigate the possible changes in serum irisin concentrations before and after treatment in hypothyroid subjects. METHODS: The study included 26 patients with overt hypothyroidism due to Hashimoto thyroiditis and 19 healthy subjects...
May 18, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29767680/propensity-for-adverse-pregnancy-outcomes-in-african-american-women-may-be-explained-by-low-energy-expenditure-in-early-pregnancy
#4
Jasper Most, L Anne Gilmore, Abby D Altazan, Marshall St Amant, Robbie A Beyl, Eric Ravussin, Leanne M Redman
Background: African-American (AA) women have poorer pregnancy outcomes and studies in nonpregnant women suggest a different etiology of weight gain in AA compared with white women. We hypothesized that physiologic factors such as low energy expenditure and physical activity would be present in AA compared with white women in pregnancy. Objective: We aimed to identify physiologic risk factors for disordered energy balance in AA and white women early in pregnancy...
May 14, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29766681/evaluation-of-thyroid-hormone-levels-and-urinary-iodine-concentrations-in-koreans-based-on-the-data-from-korea-national-health-and-nutrition-examination-survey-vi-2013-to-2015
#5
REVIEW
Jae Hoon Chung
No nationwide data have been published about thyroid hormone levels and urinary iodine concentrations (UICs) in Korea. The Korea Centers for Disease Control and Prevention and the Korean Thyroid Association established a project to evaluate the nationwide thyroid hormone profile and UICs in healthy Koreans as part of the Korea National Health and Nutrition Examination Survey (KNHANES) VI (2013 to 2015), a nationwide, cross-sectional survey of the Korean population that enrolled 7,061 individuals who were weighted to represent the entire Korean population...
May 4, 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29761770/-combination-therapy-of-thyroxine-and-triiodothyronine-in-hypothyroid-patients
#6
Birte Nygaard, Michael E Røder, Jesper Karmisholt, Jette Kolding Kristensen
Decreased quality of life is described more often in hypothyroid patients, who are treated with a synthetic form of thyroxine (L-T4), than in euthyroid controls. A combination of L-T4 and a synthetic form of triiodothyronine (L-T3) has been suggested; however, previous meta-analyses on unselected patients did not find any effect. Recent studies demonstrate, that the overall hypothalamic-pituitary-thyroid-tissue homeostasis could be more complex than previously suggested. Polymorphisms in deiodinase and thyroid hormone transporter genes could theoretically explain, why a minor subgroup of hypothyroid patients seem to have an effect of L-T4/L-T3 combination therapy...
May 7, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29760914/gas-stunning-with-co-2-affected-meat-color-lipid-peroxidation-oxidative-stress-and-gene-expression-of-mitogen-activated-protein-kinases-glutathione-s-transferases-and-cu-zn-superoxide-dismutase-in-the-skeletal-muscles-of-broilers
#7
Lei Xu, Haijun Zhang, Hongyuan Yue, Shugeng Wu, Haiming Yang, Zhiyue Wang, Guanghai Qi
Background: Meat color and lipid peroxidation are important traits related to meat quality. CO2 concentration is a critical factor that can affect meat quality in the commercial use of gas stunning (GS). However, the effect and mechanism of CO2 stunning on meat color and lipid peroxidation during long-term storage remain poorly studied. We aimed to study the effects of GS methods, especially CO2 concentration, on meat color and meat lipid peroxidation in broilers during long-term storage at 4 °C and to explore the potential mechanism of meat color change via lipid peroxidation and the inner lipid peroxide scavenging system...
2018: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/29755326/transient-hypothyroidism-during-lactation-arrests-myelination-in-the-anterior-commissure-of-rats-a-magnetic-resonance-image-and-electron-microscope-study
#8
Federico S Lucia, Jesús Pacheco-Torres, Susana González-Granero, Santiago Canals, María-Jesús Obregón, José M García-Verdugo, Pere Berbel
Thyroid hormone deficiency at early postnatal ages affects the cytoarchitecture and function of neocortical and telencephalic limbic areas, leading to impaired associative memory and in a wide spectrum of neurological and mental diseases. Neocortical areas project interhemispheric axons mostly through the corpus callosum and to a lesser extent through the anterior commissure (AC), while limbic areas mostly project through the AC and hippocampal commissures. Functional magnetic resonance data from children with late diagnosed congenital hypothyroidism and abnormal verbal memory processing, suggest altered ipsilateral and contralateral telencephalic connections...
2018: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/29754056/nitric-oxide-is-involved-in-the-hypothyroidism-with-significant-morphology-changes-in-female-wistar-rats-induced-by-chronic-exposure-to-high-water-iodine-from-potassium-iodate
#9
Shengzhong Rong, Yanhui Gao, Yanmei Yang, Hanwen Shao, Akinkunmi Paul Okekunle, Chunpeng Lv, Yang Du, Hongna Sun, Yuting Jiang, Gottfried M Darko, Dianjun Sun
Epidemiological studies indicated that chronic exposure to high water iodine is associated with primary hypothyroidism (PH) and subclinical hypothyroidism (SCH). However, the mechanism is not well understood. In this study, we explored whether chronic exposure to high water iodine from potassium iodate (KIO3 ) can induce hypothyroidism in addition to determining if nitric oxide (NO) is involved in the pathogenesis. 96 female Wistar rats were divided into six groups: control, I1000μg/L , I3000μg/L , I6000μg/L , N-nitro-L-arginine methylester (L-NAME) and L-NAME+I6000μg/L ...
May 3, 2018: Chemosphere
https://www.readbyqxmd.com/read/29751674/comparative-analysis-of-zearalenone-effects-on-thyroid-receptor-alpha-tr%C3%AE-and-beta-tr%C3%AE-expression-in-rat-primary-cerebellar-cell-cultures
#10
David Sandor Kiss, Eniko Ioja, Istvan Toth, Zoltan Barany, Gergely Jocsak, Tibor Bartha, Tamas L Horvath, Attila Zsarnovszky
Thyroid receptors play an important role in postnatal brain development. Zearalenone (ZEN), a major mycotoxin of Fusarium fungi, is well known to cause serious health problems in animals and humans through various mechanisms, including the physiological pathways of thyroid hormone (TH). In the present study, we aimed to investigate the expression of thyroid receptors α (TRα) and β (TRβ) in primary cerebellar neurons in the presence or absence of glia and following ZEN treatment, using quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and Western blot...
May 11, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29742907/new-interfaces-of-thyroid-hormone-actions-with-blood-coagulation-and-thrombosis
#11
Paul J Davis, Shaker A Mousa, Geraldine P Schechter
Substantial clinical evidence indicates hyperthyroidism enhances coagulation and increases the risk of thrombosis. In vitro and clinical evidence implicate multiple mechanisms for this risk. Genomic actions of thyroid hormone as 3,5,3'-triiodo-L-thyronine (T3 ) via a nuclear thyroid hormone receptor have been implicated, but recent evidence shows that nongenomic mechanisms initiated at the receptor for L-thyroxine (T4 ) on platelet integrin αvβ3 are prothrombotic. The T4 -initiated mechanisms involve platelet activation and, in addition, cellular production of cytokines and chemokines such as CX3CL1 with procoagulatory activities...
January 1, 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29742817/effects-of-thyroid-dysfunction-on-reproductive-hormones-in-female-rats
#12
Juan Liu, Meng Guo, Xusong Hu, Xuechun Weng, Ye Tian, Kaili Xu, Dai Heng, Wenbo Liu, Yu Ding, Yanzhou Yang, Cheng Zhang
Thyroid hormones (THs) play a critical role in the development of ovarian cells. Although the effects of THs on female reproduction are of great interest, the mechanism remains unclear. We investigated the effects of TH dysregulation on reproductive hormones in rats. Propylthiouracil (PTU) and L-thyroxine were administered to rats to induce hypo- and hyper-thyroidism, respectively, and the reproductive hormone profiles were analyzed by radioimmunoassay. Ovarian histology was evaluated with H&E staining, and gene protein level or mRNA content was analyzed by western blotting or RT-PCR...
May 10, 2018: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/29737233/excessive-iodine-intake-and-subclinical-hypothyroidism-in-children-and-adolescents-aged-6-19-years-results-of-the-sixth-korean-national-health-and-nutrition-examination-survey-knhanes-2013-2015
#13
Min Jae Kang, Il Tae Hwang, Hye Rim Chung
BACKGROUND: Iodine is an important element for the thyroid hormone production, and its deficiency or excessive intake is associated with various thyroid diseases. Little is known about the association between iodine status and thyroid function among children and adolescents living in iodine-rich areas, therefore, we analyzed this association using data from a nationwide survey. METHODS: From the Korea National Health and Nutrition Examination Surveys (KNHANES) VI (2013-2015) data, 1288 subjects (711 male) aged 6-19 years who underwent urinary iodine concentration (UIC) test and 1000 subjects (564 male) aged 10-19 years who underwent thyroid function test were included in this study...
May 8, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29736988/use-of-basal-and-trh-stimulated-plasma-growth-hormone-concentrations-to-differentiate-between-primary-hypothyroidism-and-nonthyroidal-illness-in-dogs
#14
Tera Pijnacker, Hans S Kooistra, Cathelijne F Vermeulen, Merel van der Vinne, Marrit Prins, Sara Galac, Jan A Mol
BACKGROUND: A low plasma total thyroxine (TT4 ) concentration in combination with a plasma TSH concentration within reference range does not distinguish between hypothyroidism and nonthyroidal illness (NTI) in dogs. Hypothyroidism is associated with TSH-releasing hormone (TRH)-induced increased release of growth hormone (GH). HYPOTHESIS: Basal and TRH-induced plasma GH concentrations can be used to distinguish hypothyroid dogs from NTI dogs. ANIMALS: Twenty-one dogs with signs consistent with hypothyroidism, a low plasma TT4 concentration, and a plasma TSH concentration within reference interval...
May 7, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29733970/thyroxine-binding-globulin-deficiency-due-to-a-novel-serpina7-mutation-clinical-characterization-analysis-of-x-chromosome-inactivation-pattern-and-protein-structural-modeling
#15
Cristiane Jeyce Gomes Lima, Andressa Aby Faraj Linhares Maciel, Matheus de Oliveira Andrade, Vinicius Santos da Cunha, Juliana Forte Mazzeu, Lucas Bleicher, Francisco de Assis Rocha Neves, Adriana Lofrano-Porto
OBJECTIVE: Thyroxine-binding globulin (TBG) is the major human thyroid hormone transport protein, encoded by the SERPINA7 gene (Xq22.2). We aim to investigate the molecular basis of partial TBG deficiency (TBG-PD) in a female, by evaluating the X-chromosome inactivation pattern as well as the mutant protein structural modeling. DESIGN AND METHODS: Sequencing of the coding region of the SERPINA7 gene was performed in a female with a TBG-PD phenotype and her first-degree relatives...
May 4, 2018: Gene
https://www.readbyqxmd.com/read/29721936/overexpression-of-type-3-iodothyronine-deiodinase-reduces-cone-death-in-the-leber-congenital-amaurosis-model-mice
#16
Fan Yang, Hongwei Ma, Sanford L Boye, William W Hauswirth, Xi-Qin Ding
Leber congenital amaurosis (LCA) is a devastating pediatric retinal degenerative disease, accounting for 20% of blindness in children attending schools for the blind. Mutations in the RPE65 gene, which encodes the retinal pigment epithelium-specific isomerohydrolase RPE65, account for 16% of all LCA cases. Recent findings have linked cone photoreceptor viability to thyroid hormone (TH) signaling. TH signaling regulates cell proliferation, differentiation, and metabolism. At the cellular level, TH action is regulated by the two iodothyronine deiodinases, DIO2 and DIO3...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29721776/formation-of-lamellar-bodies-in-rat-liver-mitochondria-in-hyperthyroidism
#17
Natalya I Venediktova, Lubov L Pavlik, Natalia V Belosludtseva, Natalya V Khmil, Svetlana V Murzaeva, Galina D Mironova
In the present work, ultrastructural changes of rat liver mitochondria in hyperthyroidism were studied. Hyperthyroidism was induced in male Wistar rats by daily administration of 100 μg thyroxin per 100 g body weight for 5 days. The level of triiodothyronine and thyroxine increased 3- and 4-fold, respectively, in comparison with the same parameters in the control group, indicating the development of hyperthyroidism in experimental animals. It was found that under this experimental pathology 58% of the mitochondria are swollen, with their matrix enlightened, as compared to the control...
May 3, 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29720960/increased-requirement-of-replacement-doses-of-levothyroxine-caused-by-liver-cirrhosis
#18
Salvatore Benvenga, Giovanni Capodicasa, Sarah Perelli, Silvia Martina Ferrari, Poupak Fallahi, Alessandro Antonelli
Background: Since hypothyroidism is a fairly common dysfunction, levothyroxine (L-T4) is one of the most prescribed medications. Approximately 70% of the administered L-T4 dose is absorbed. The absorption process takes place in the small intestine. Some disorders of the digestive system and some medicines, supplements, and drinks cause L-T4 malabsorption, resulting in failure of serum TSH to be normal. Only rarely liver cirrhosis is mentioned as causing L-T4 malabsorption. Case report: In this study, we report increased requirement of daily doses of l-thyroxine in two patients with the atrophic variant of Hashimoto's thyroiditis and liver cirrhosis...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29717686/supplementing-sow-diets-with-palm-oil-during-late-gestation-and-lactation-effects-on-milk-production-sow-hormonal-profiles-and-growth-and-development-of-her-offspring
#19
J Laws, D T Juniper, I J Lean, E Amusquivar, E Herrera, P F Dodds, L Clarke
The supplementing of sow diets with lipids during pregnancy and lactation has been shown to reduce sow condition loss and improve piglet performance. The aim of this study was to determine the effects of supplemental palm oil (PO) on sow performance, plasma metabolites and hormones, milk profiles and pre-weaning piglet development. A commercial sow ration (C) or an experimental diet supplemented with 10% extra energy in the form of PO, were provided from day 90 of gestation until weaning (24 to 28 days postpartum) in two groups of eight multiparous sows...
May 2, 2018: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29717202/double-domain-polyethylenimine-based-nanoparticles-for-integrin-receptor-mediated-delivery-of-plasmid-dna
#20
Hossein Sadeghpour, Bahman Khalvati, Elaheh Entezar-Almahdi, Narjes Savadi, Samira Hossaini Alhashemi, Mohammad Raoufi, Ali Dehshahri
The objective of the present study is to conjugate L-thyroxine PEI derivative onto another PEI to compensate the amine content of the whole structure which has been utilized for the ligand conjugation. Since αv β3 integrin receptors are over-expressed on cancer cells and there is binding site for L-thyroxine on these receptors, PEI conjugation by L-thyroxine along with restoring the PEI amine content might be an efficient strategy for targeted delivery using polymeric nanoparticles. The results demonstrated the ability of the PEI conjugate in the formation of nanoparticles with the size of around 210 nm with higher buffering capacity...
May 1, 2018: Scientific Reports
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