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https://www.readbyqxmd.com/read/28101489/correction-of-hypothyroidism-leads-to-change-in-lean-body-mass-without-altering-insulin-resistance
#1
Sangeetha Sirigiri, Suresh Vaikkakara, Alok Sachan, P V L N Srinivasarao, Sunil Epuri, Sailaja Anantarapu, Arun Mukka, Srinivasa Rao Chokkapu, Ashok Venkatanarasu, Ravi Poojari
BACKGROUND: Hypothyroidism is associated with insulin resistance, dyslipidemia, and abnormal body composition. This study assessed changes in body composition and insulin resistance after thyroxine (T4) replacement in overt hypothyroidism. METHODS: In this prospective longitudinal study carried out in a tertiary care center, adult nondiabetic patients with overt hypothyroidism were rendered euthyroid on T4. Anthropometry including skinfold thickness (SFT) at the triceps and subscapularis was recorded...
December 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/28101488/thyroid-function-and-high-sensitivity-c-reactive-protein-in-cross-sectional-results-from-the-brazilian-longitudinal-study-of-adult-health-elsa-brasil-effect-of-adiposity-and-insulin-resistance
#2
Érique José F Peixoto de Miranda, Márcio Sommer Bittencourt, Itamar S Santos, Paulo A Lotufo, Isabela M Benseñor
BACKGROUND: Subclinical hypothyroidism (SCH) is associated with an increased cardiovascular risk, but little information is available about its association with high-sensitivity C-reactive protein (hs-CRP). OBJECTIVES: This study aims to analyze the association between SCH and hs-CRP using baseline data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). METHODS: The study has a cross-sectional design. We included subjects with normal thyroid function (thyroid-stimulating hormone, TSH, 0...
December 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/28077136/increased-leptin-adiponectin-ratio-relates-to-low-normal-thyroid-function-in-metabolic-syndrome
#3
Lynnda J N van Tienhoven-Wind, Robin P F Dullaart
BACKGROUND: Low-normal thyroid function within the euthyroid range may contribute to increased atherosclerosis susceptibility. The leptin/adiponectin (L/A) ratio is associated with cardiovascular disease and reflects adipose tissue dysfunction. Relationships of the L/A ratio with low-normal thyroid function are unknown. METHODS: Relationships of thyroid stimulating hormone (TSH) and free thyroxine (free T4) with leptin, adiponectin and the L/A ratio in euthyroid subjects were documented in 67 fasting subjects with metabolic syndrome (Mets) and 86 euthyroid subjects without MetS (TSH and free T4 levels within the institutional reference range)...
January 11, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28076316/changes-of-thyroid-hormonal-status-in-patients-receiving-ketogenic-diet-due-to-intractable-epilepsy
#4
Engin Kose, Orkide Guzel, Korcan Demir, Nur Arslan
BACKGROUND: Ketogenic diet (KD), which is high in fat and low in carbohydrates, mimics the metabolic state of starvation and is used therapeutically for pharmacoresistant epilepsy. It is known that generation of triiodothyronine (T3) from thyroxine (T4) decreases during fasting periods. The aim of this study was to evaluate the thyroid function of children receiving KD for at least 1 year due to drug-resistant epilepsy. METHODS: A total of 120 patients [63 males, 52...
January 11, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28070054/-van-wyk-grumbach-syndrome-a-case-report-and-%C3%A2-literature-review
#5
Ping Jin, Qin Zhang, Zhaohui Mo, Fan Yang, Yanhong Xie
Van Wyk-Grumbach syndrome (VWGS) is a rare complication of prolonged untreated juvenile hypothyroidism characterized by precocious puberty and enlarged multicystic ovaries. A 13-year-old girl visited our outpatient clinic due to menstrual irregularities. She had precocious puberty, pituitary hyperplasia and multiple cystic ovaries in addition to clinical signs of severe congenital hypothyroidism. After the initiation of L-thyroxine therapy, the symptoms were alleviated in a short time. This rare syndrome is easy to be misdiagnosed as pituitary and ovarian tumor...
December 28, 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28058547/effect-of-thyroid-remnant-volume-on-the-risk-of-hypothyroidism-after-hemithyroidectomy-a-prospective-study
#6
Brian Hung-Hin Lang, Carlos K H Wong, Kai Pun Wong, Kelvin Ka-Wan Chu, Tony W H Shek
BACKGROUND: Hypothyroidism is a common sequel after a hemithyroidectomy. Although various risk factors leading to hypothyroidism have been reported, the effect of the contralateral lobe's volume has been understudied. This study aimed to examine the association between the preoperative contralateral lobe's volume and the risk of postoperative hypothyroidism. METHODS: During a 2-year period, 150 eligible patients undergoing a hemithyroidectomy were evaluated. The volume of the contralateral nonexcised lobe was estimated preoperatively by independent assessors on ultrasonography using the following formula: width (in cm) × depth (in cm) × length (in cm) × (π/6), adjusted for the body surface area (BSA)...
January 5, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28055088/myxedema-psychosis-in-a-patient-with-undiagnosed-hashimoto-thyroiditis
#7
Matthew M Mavroson, Nirav Patel, Eleonora Akker
Myxedema psychosis is uncommon in patients with primary hypothyroidism. Most often, this disease state can be found in patients with Hashimoto thyroiditis or after total thyroidectomy. Chronic hypothyroidism can lead to an insidious onset of psychiatric symptoms in patients, such as dementia, delirium, psychosis, hallucinations, and coma. A 31-year-old man with an unremarkable medical history was brought to the psychiatric emergency department for new-onset aggression, paranoid behavior, and hallucinations for 4 days...
January 1, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/28052998/dissecting-thyroid-hormone-transport-and-metabolism-in-dendritic-cells
#8
Nicolás Gigena, Vanina A Alamino, María Del Mar Montesinos, Magalí Nazar, Ruy A Louzada, Simone M Wajner, Ana L Maia, Ana M Masini-Repiso, Denise P Carvalho, Graciela A Cremaschi, Claudia G Pellizas
We reported thyroid hormone (TH) receptor expression in murine dendritic cells (DCs) and 3,5,3'-triiodothyronine (T3)-dependent stimulation of DC maturation and ability to develop a Th1-type adaptive response. Moreover, an increased DC capacity to promote antigen-specific cytotoxic T-cell activity, exploited in a DC-based antitumor vaccination protocol, was revealed. However, putative effects of the main circulating TH, l-thyroxine (T4) and the mechanisms of TH transport and metabolism at DC level, crucial events for TH action at target cell level, were not known...
February 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28052518/effects-of-enzymatically-treated-artemisia-annua-l-on-growth-performance-and-some-blood-parameters-of-broilers-exposed-to-heat-stress
#9
Xiaoli Wan, Luyi Jiang, Haoran Zhong, Yufang Lu, Lili Zhang, Tian Wang
To evaluate the effects of enzymatically treated Artemisia annua L. (EA) on growth performance and some blood parameters of broilers exposed to heat stress (HS), 320 22-day-old Arbor Acres male broilers were randomly allotted into five groups with eight replicates of eight birds each. Broilers in the control group were housed at 22 ± 1°C and fed the basal diet. Broilers in the HS, HS-EA0.75 , HS-EA1.00 and HS-EA1.25 groups were reared under HS (34 ± 1°C for 8 h/day and 22 ± 1°C for 16 h/day), and fed basal diet with 0, 0...
January 4, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28018461/hashimoto-thyroiditis-with-an-unusual-presentation-of-cardiac-tamponade-in-noonan-syndrome
#10
Mi Ji Lee, Byung Young Kim, Jae Sook Ma, Young Earl Choi, Young Ok Kim, Hwa Jin Cho, Chan Jong Kim
Noonan syndrome is an autosomal dominant, multisystem disorder. Autoimmune thyroiditis with hypothyroidism is an infrequent feature in patients with Noonan syndrome. A 16-year-old boy was admitted because of chest discomfort and dyspnea; an echocardiogram revealed pericardial effusion. Additional investigations led to a diagnosis of severe hypothyroidism due to Hashimoto thyroiditis. The patient was treated with L-thyroxine at 0.15 mg daily. However, during admission, he developed symptoms of cardiac tamponade...
November 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/28012382/a-validated-lc-ms-ms-method-for-thyroid-hormone-determination-in-sea-lamprey-petromyzon-marinus-plasma-gill-kidney-and-liver
#11
Ugo Bussy, Yu-Wen Chung-Davidson, Ke Li, Skye D Fissette, Ethan G Buchinger, Weiming Li
A UPLC-MS/MS method was developed to provide a reproducible, sensitive and quantitative assay to determine thyroid hormones in sea lamprey tissues and plasma. l-Thyroxine (T4) and its two triiodo-thyronine isomers have been simultaneously quantified and validated for plasma, gill, liver, and kidney matrices. Multiple sample preparation techniques were investigated to achieve optimal sample matrix digestion and clean-up. Enzymatic digestion followed by protein precipitation was selected to process the samples...
January 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28008862/subclinical-hypothyroidism-in-children-may-lead-to-dyslipidemia-and-increased-carotid-intima-media-thickness
#12
Edip Ünal, Alper Akın, Ruken Yıldırım, Vasfiye Demir, İsmail Yıldız, Yusuf Kenan Haspolat
OBJECTIVE: Subclinical hypothyroidism (SH) is defined as elevated serum thyroid stimulating hormone (TSH) level with normal range of free thyroxine (fT4). There are very few studies in the literature reporting on the effect of SH on lipid metabolism and carotid intima-media thickness (CIMT) in children. METHODS: The study included 38 children diagnosed with SH and a control group comprising 38 healthy, euthyroid children. Subclinical hypothyroidism was diagnosed based on elevated TSH level (4...
December 23, 2016: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28006665/alteration-of-thyroid-hormone-concentrations-in-juvenile-chinook-salmon-oncorhynchus-tshawytscha-exposed-to-polybrominated-diphenyl-ethers-bde-47-and-bde-99
#13
Mary R Arkoosh, Ahna L Van Gaest, Stacy A Strickland, Greg P Hutchinson, Alex B Krupkin, Joseph P Dietrich
Polybrominated diphenyl ethers (PBDEs) have been used as flame-retardants in consumer products and are currently detected in salmon globally. The two most predominant PBDE congeners found in salmon are BDE-47 (2,2',4,4'-tetrabromodiphenyl ether) and BDE-99 (2,2',4,4',5-pentabromodiphenyl ether). In the present study, groups of juvenile Pacific Chinook salmon were fed five environmentally relevant concentrations of either BDE-47 (0.3-552 ng total PBDEs/g food), BDE-99 (0.3-580 ng total PBDEs/g food), or nearly equal mixtures of both congeners (0...
December 8, 2016: Chemosphere
https://www.readbyqxmd.com/read/27974077/urinary-iodine-concentration-identifies-pregnant-women-as-iodine-deficient-yet-school-aged-children-as-iodine-sufficient-in-rural-niger
#14
Sonja Y Hess, Césaire T Ouédraogo, Rebecca R Young, Ibrahim F Bamba, Sara Stinca, Michael B Zimmermann, K Ryan Wessells
OBJECTIVE: To assess iodine status among pregnant women in rural Zinder, Niger and to compare their status with the iodine status of school-aged children from the same households. DESIGN: Seventy-three villages in the catchment area of sixteen health centres were randomly selected to participate in the cross-sectional survey. SETTING: Salt iodization is mandatory in Niger, requiring 20-60 ppm iodine at the retail level. SUBJECTS: A spot urine sample was collected from randomly selected pregnant women (n 662) and one school-aged child from the same household (n 373)...
December 15, 2016: Public Health Nutrition
https://www.readbyqxmd.com/read/27972159/subclinical-hypothyroidism-in-pediatric-population-treated-with-l-thyroxine-a-retrospective-observational-analysis-on-2001-2014-administrative-data
#15
N A Greggio, S Calabria, A Pedrini, E Rossi
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27966590/gait-patterns-associated-with-thyroid-function-the-rotterdam-study
#16
Arjola Bano, Layal Chaker, Sirwan K L Darweesh, Tim I M Korevaar, Francesco U S Mattace-Raso, Abbas Dehghan, Oscar H Franco, Jos N van der Geest, M Arfan Ikram, Robin P Peeters
Gait is an important health indicator and poor gait is strongly associated with disability and risk of falls. Thyroid dysfunction is suggested as a potential determinant of gait deterioration, but this has not been explored in a population-based study. We therefore investigated the association of thyroid function with gait patterns in 2645 participants from the Rotterdam Study with data available on TSH (thyroid-stimulating hormone), FT4 (free thyroxine) and gait, without known thyroid disease or dementia. The primary outcome was Global gait (standardized Z-score), while secondary outcomes included gait domains (Rhythm, Variability, Phases, Pace, Base of support, Tandem, Turning) and velocity...
December 14, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27959899/effects-of-in-utero-thyroxine-exposure-on-murine-cranial-suture-growth
#17
R Nicole Howie, Emily L Durham, Laurel Black, Grace Bennfors, Trish E Parsons, Mohammed E Elsalanty, Jack C Yu, Seth M Weinberg, James J Cray
Large scale surveillance studies, case studies, as well as cohort studies have identified the influence of thyroid hormones on calvarial growth and development. Surveillance data suggests maternal thyroid disorders (hyperthyroidism, hypothyroidism with pharmacological replacement, and Maternal Graves Disease) are linked to as much as a 2.5 fold increased risk for craniosynostosis. Craniosynostosis is the premature fusion of one or more calvarial growth sites (sutures) prior to the completion of brain expansion...
2016: PloS One
https://www.readbyqxmd.com/read/27933173/a-rare-case-of-gestational-thyrotoxicosis-as-a-cause-of-acute-myocardial-infarction
#18
Varalaxmi Bhavani Nannaka, Dmitry Lvovsky
: Angina pectoris in pregnancy is unusual and Prinzmetal's angina is much rarer. It accounts for 2% of all cases of angina. It is caused by vasospasm, but the mechanism of spasm is unknown but has been linked with hyperthyroidism in some studies. Patients with thyrotoxicosis-induced acute myocardial infarction are unusual and almost all reported cases have been associated with Graves' disease. Human chorionic gonadotropin hormone-induced hyperthyroidism occurs in about 1.4% of pregnant women, mostly when hCG levels are above 70-80 000 IU/L...
2016: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/27929713/postoperative-thyroglobulin-and-neck-ultrasound-in-the-risk-re-stratification-and-decision-to-perform-131-i-ablation
#19
Antonio Matrone, Carla Gambale, Paolo Piaggi, David Viola, Carlotta Giani, Laura Agate, Valeria Bottici, Francesca Bianchi, Gabriele Materazzi, Paolo Vitti, Eleonora Molinaro, Rossella Elisei
CONTEXT: For many years, total thyroidectomy (TTx) and radioiodine remnant ablation (RRA) represented the initial treatment of differentiated thyroid cancer (DTC). There is currently much debate surrounding the clinical impact of RRA, particularly in low (LR) and intermediate (IR) risk DTC. OBJECTIVE: To evaluate the role of postoperative High-Sensitive Thyroglobulin on L-thyroxine (LT4-HSTg) and postoperative neck ultrasound (nUS) in risk re-stratification and decision to perform RRA...
December 8, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27923249/thyroid-function-in-human-obesity-underlying-mechanisms
#20
L C Fontenelle, M M Feitosa, J S Severo, T E C Freitas, J B S Morais, F L Torres-Leal, G S Henriques, D do Nascimento Marreiro
Obesity is associated with several metabolic and endocrine disorders; and changes in plasma concentrations, secretion patterns, and clearance of various hormones are observed in obese patients. In this context, recent research has shown that overweight can influence the function of the thyroid gland, usually leading to increased thyrotropin concentrations and changes in the ratio between the hormones triiodothyronine and thyroxine, though within the normal range. The etiology of these changes is still unclear; however, several mechanisms have been proposed including the adaptive process to increase energy expenditure, hyperleptinemia, changes in the activity of deiodinases, the presence of thyroid hormones resistance, chronic low-grade inflammation, and insulin resistance...
December 2016: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
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