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https://www.readbyqxmd.com/read/29327786/differential-effects-of-experimental-hyperthyroidism-on-declined-immunity-of-broiler-chicken
#1
M S Khilji, M A Sandhu, M S Yousaf, A A Saeed, H U Rehman, H Zaneb, M A Rashid
Thyroid hormones (THs) are involved in the development of lymphoid organs and regulation of immune function in birds. However, their role as an immune-modulator in the hyperthyroid state is still debatable. To explore the interrelationship of thyroxine (T4 ) and the immune system, chicks were divided into three groups. Group I was comprised of control birds, who received the basal diet while group II and III were given diets supplemented with 5 μg and 10 μg thyroxine/kg feed, respectively, from 15 to 28 days of age...
January 12, 2018: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29325045/mean-high-dose-l-thyroxine-treatment-is-efficient-and-safe-to-achieve-a-normal-iq-in-young-adult-patients-with-congenital-hypothyroidism
#2
Paulina Aleksander, Michaela Brückner-Spieler, Anne-Marie Stöhr, Erwin Lankes, Peter Kühnen, Dirk Schnabel, Andrea Ernert, Walter Stäblein, Maria E Craig, Oliver Blankenstein, Annette Grüters, Heiko Krude
Context: The optimal levothyroxine (LT4) dose required to treat congenital hypothyroidism (CH) remains unclear, with a debate if higher starting doses (>10µg/kg) are necessary and safe for normal Intelligence Quotient (IQ). Objective: To examine the psychomotor, metabolic and quality of life outcome in patients with CH treated with a mean high initial LT4 dose. Design, settings, participants: A cross- sectional cohort study of CH patients identified in the Berlin newborn screening programme from 1979-2003...
January 9, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29321381/association-between-genetic-polymorphism-and-levothyroxine-bioavailability-in-hypothyroid-patients
#3
Merve Arici, Ezgi Oztas, Fatih Yanar, Nihat Aksakal, Beyza Ozcinar, Gul Ozhan
Thyroid hormones play a vital role in the human body for growth and differentiation, regulation of energy metabolism, and physiological function. Hypothyroidism is a common endocrine disorder, which generally results from diminished normal circulating concentrations of serum thyroxine (fT4) and triiodothyronine (fT3). The primary choice in hypothyroidism treatment is oral administration of levothyroxine (L-T4), a synthetic T4 hormone, as approximately 100-125 μg/day. Generally, dose adjustment is made by trial and error approach...
January 11, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29319368/association-of-increased-eomesodermin-bcl6-and-granzyme-b-expression-with-major-clinical-manifestations-of-hashimoto-s-thyroiditis-an-observational-study
#4
Mario Štefanić, Stana Tokić, Mirjana Suver Stević, Ljubica Glavaš-Obrovac
PURPOSE: Studies of cytotoxic T cells and their respective lineage master regulators have been limited in Hashimoto's thyroiditis (HT). It is unclear whether their transcriptomes are changed in HT patients and how these changes are associated with the thyroid damage, major clinical manifestations, and disease progression. METHODS: We explored the gene expression patterns of selected transcription factors [eomesodermin (EOMES), BACH2, BCL6, TCF1] and cytolytic molecules [granzyme B (GZMB)] in peripheral blood (PB) T cells of 10 healthy controls and 30 HT patients of various subtypes (hypothyroid, untreated HT; L-thyroxine (T4)-treated HT, and spontaneously euthyroid HT) using real-time quantitative PCR...
January 10, 2018: Immunological Investigations
https://www.readbyqxmd.com/read/29316865/effects-of-thyroid-stimulating-hormone-on-peripheral-thyroid-hormone-metabolism-and-serum-lipids
#5
Carolien M Beukhof, Elske Theresia Massolt, Theo J Visser, Tim Korevaar, Marco Medici, Wouter W de Herder, Jeanine Roeters van Lennep, Monique Mulder, Yolanda B de Rijke, Christoph Reiners, Frederik A Verburg, Robin Peeters
BACKGROUND: Subclinical hypothyroidism is associated with dyslipidemia and atherosclerosis. Whether part of these effects are mediated via direct effects of TSH on peripheral TH metabolism and/or concentrations of serum lipids is not clear. OBJECTIVE: To examine whether thyroid stimulating hormone (TSH) has direct effects on peripheral thyroid hormone (TH) metabolism and serum lipids. METHODS: We retrospectively analyzed 82 patients with differentiated thyroid cancer...
January 9, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29314156/simultaneous-quantification-of-t4-t3-rt3-3-5-t2-and-3-3-t2-in-larval-zebrafish-danio-rerio-as-a-model-to-study-exposure-to-polychlorinated-biphenyls
#6
Xiaopeng Chen, Kyla M Walter, Galen W Miller, Pamela J Lein, Birgit Puschner
Environmental toxicants that interfere with thyroid hormone (TH) signaling can impact growth and development in animals and humans. Zebrafish represent a model to study chemically-induced TH disruption, prompting the need for sensitive detection of THs. Simultaneous quantification of 3,3',5-triiodo-L-thyronine (T3), thyroxine (T4), 3,3',5'-triiodo-L-thyronine (rT3), 3,5-diiodo-L-thyronine (3,5-T2), and 3,3'-diiodo-L-thyronine (3,3'-T2) in zebrafish larvae was achieved by ultra-performance liquid chromatography-tandem mass spectrometry in positive ion mode...
January 3, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29310665/a-patient-specific-treatment-model-for-graves-hyperthyroidism
#7
Balamurugan Pandiyan, Stephen J Merrill, Flavia Di Bari, Alessandro Antonelli, Salvatore Benvenga
BACKGROUND: Graves' is disease an autoimmune disorder of the thyroid gland caused by circulating anti-thyroid receptor antibodies (TRAb) in the serum. TRAb mimics the action of thyroid stimulating hormone (TSH) and stimulates the thyroid hormone receptor (TSHR), which results in hyperthyroidism (overactive thyroid gland) and goiter. Methimazole (MMI) is used for hyperthyroidism treatment for patients with Graves' disease. METHODS: We have developed a model using a system of ordinary differential equations for hyperthyroidism treatment with MMI...
January 9, 2018: Theoretical Biology & Medical Modelling
https://www.readbyqxmd.com/read/29306458/impact-of-subclinical-hypothyroidism-on-clinical-outcomes-following-percutaneous-coronary-intervention
#8
Yonggu Lee, Young-Hyo Lim, Jeong-Hun Shin, Jinkyu Park, Jinho Shin
BACKGROUND: Similar to overt hypothyroidism, subclinical hypothyroidism (SCH) has been reported to increase the risk of cardiovascular disease. However, the influence of SCH on clinical outcomes following percutaneous coronary intervention (PCI) remains unclear. METHODS: We performed a prospective cohort study. SCH was defined as a thyroid-stimulating hormone (TSH) level ≥4.5mIU/l and a normal level of free thyroxine (FT4). A composite event was defined as the combination of cardiac death, non-fatal myocardial infarction (MI) and repeat revascularization...
February 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29306024/organophosphate-triesters-and-selected-metabolites-enhance-binding-of-thyroxine-to-human-transthyretin-in-vitro
#9
Katie L Hill, Timo Hamers, Jorke H Kamstra, William G Willmore, Robert J Letcher
The toxicological properties of organophosphate (OP) triesters that are used as flame retardants and plasticizers are currently not well understood, though increasing evidence suggests they can affect the thyroid system. Perturbation of thyroid hormone (TH) transport is one mechanism of action that may affect thyroid function. The present study applied an in vitro competitive protein binding assay with thyroxine (T4) and human transthyretin (hTTR) to determine the potential for the OP triesters, TDCIPP (tris(1,3-dichloro-2-propyl) phosphate), TBOEP (tris(butoxyethyl) phosphate), TEP (triethyl phosphate), TPHP (triphenyl phosphate), p-OH-TPHP (para-hydroxy triphenyl phosphate), and the OP diester DPHP (diphenyl phosphate), to competitively displace T4 from hTTR...
January 3, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29304184/cardiac-ischemia-reperfusion-injury-is-inversely-affected-by-thyroid-hormones-excess-or-deficiency-in-male-wistar-rats
#10
Fernando A C Seara, Leonardo Maciel, Raiana A Q Barbosa, Nayana C Rodrigues, Anderson L B Silveira, Michelle P Marassi, Adriana B Carvalho, José Hamilton M Nascimento, Emerson L Olivares
AIM: Thyroid dysfunctions can increase the risk of myocardial ischemia and infarction. However, the repercussions on cardiac ischemia/reperfusion (IR) injury remain unclear so far. We report here the effects of hypothyroidism and thyrotoxicosis in the susceptibility to IR injury in isolated rat hearts compared to euthyroid condition and the potential role of antioxidant enzymes. METHODS: Hypothyroidism and thyrotoxicosis were induced by administration of methimazole (MMZ, 300 mg/L) and thyroxine (T4, 12 mg/L), respectively in drinking water for 35 days...
2018: PloS One
https://www.readbyqxmd.com/read/29303614/red-palm-oil-supplementation-does-not-increase-blood-glucose-or-serum-lipids-levels-in-wistar-rats-with-different-thyroid-status
#11
H Rauchová, M Vokurková, S Pavelka, I Vaněčková, N Tribulová, T Soukup
Red palm oil (RPO) is a rich natural source of antioxidant vitamins, namely carotenes, tocopherols and tocotrienols. However, it contains approximately 50 % saturated fatty acids the regular consumption of which could negatively modify lipid profile. The aim of our study was to test whether 7 weeks of RPO supplementation (1 g/kg body weight/day) would affect blood glucose and lipid metabolism in adult male Wistar rats with altered thyroid status. We induced hypothyroidism and hyperthyroidism in rats by oral administration of either methimazole or mixture of thyroid hormones...
January 5, 2018: Physiological Research
https://www.readbyqxmd.com/read/29301248/differences-in-the-plasma-proteome-of-patients-with-hypothyroidism-before-and-after-thyroid-hormone-replacement-a-proteomic-analysis
#12
Assim A Alfadda, Hicham Benabdelkamel, Afshan Masood, Anwar A Jammah, Aishah A Ekhzaimy
Thyroid hormone is a potent stimulator of metabolism, playing a critical role in regulating energy expenditure and in key physiological mechanisms, such as growth and development. Although administration of thyroid hormone in the form of levo thyroxine (l-thyroxine) has been used to treat hypothyroidism for many years, the precise molecular basis of its physiological actions remains uncertain. Our objective was to define the changes in circulating protein levels that characterize alterations in thyroid hormone status...
January 1, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29289659/elevated-aggressive-behavior-in-male-mice-with-thyroid-specific-prkar1a-and-global-epac1-gene-deletion
#13
Kathryn L G Russart, Danielle Huk, Randy J Nelson, Lawrence S Kirschner
Alterations in circulating thyroid hormone concentrations are associated with several psychological and behavioral disorders. In humans, behavioral disorders such as anxiety, depression, and attention-deficit hyperactivity disorder can be associated with thyroid disease. The Tpo-Cre;Prkar1aflox/flox;Epac1-/- (R1A-Epac1KO) mice, originally bred to investigate the role of exchange protein directly activated by cAMP (Epac1) in follicular thyroid cancer, displayed self-mutilating and aggressive behaviors during casual observation...
December 28, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/29289388/l-thyroxine-responsive-drop-attacks-in-childhood-benign-hereditary-chorea-a-case-report
#14
Tadashi Shiohama, Hirofumi Ohashi, Kenji Shimizu, Katsunori Fujii, Daiju Oba, Tomozumi Takatani, Mitsuhiro Kato, Naoki Shimojo
Benign hereditary chorea (BHC) is a rare autosomal dominant disease that is characterized by non-progressive chorea with early-childhood-onset, congenital hypothyroidism, and neonatal respiratory distress. Although tetrabenazine and levodopa are partly effective for chorea and drop attacks in some patients, there is no standard treatment option. We herein describe a childhood case of BHC that presented with l-thyroxine-responsive drop attacks. A genetic analysis revealed an interstitial deletion that included two enhancer regions of NKX2-1, providing genetic confirmation of BHC...
December 27, 2017: Brain & Development
https://www.readbyqxmd.com/read/29285454/hypothyroidism-and-depression-are-cytokines-the-link
#15
Parimal S Tayde, Nikhil M Bhagwat, Pragya Sharma, Bharat Sharma, Pradip P Dalwadi, Ashutosh Sonawane, Alka Subramanyam, Manoj Chadha, Premlata K Varthakavi
Context: Primary hypothyroidism has been thought of as an inflammatory condition characterized by raised levels of cytokines such as C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α). Depression is also well known to occur in hypothyroidism. Depression is also characterized by elevated inflammatory cytokines. We planned to study whether cytokines play an important part in linking these two conditions. Objectives: (1) To know the prevalence of depression in overt hypothyroidism due to autoimmune thyroid disease...
November 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29283575/in-vitro-and-in-silico-competitive-binding-of-brominated-polyphenyl-ether-contaminants-with-human-and-gull-thyroid-hormone-transport-proteins
#16
Katie L Hill, Åse-Karen Mortensen, Daniel Teclechiel, William G Willmore, Ingebrigt Sylte, Bjorn M Jenssen, Robert J Letcher
Tetradecabromo-1,4-diphenoxybenzene (TeDB-DiPhOBz) is a highly brominated additive flame retardant (FR). Debrominated photodegradates of TeDB-DiPhOBz are hydroxylated in vitro in liver microsomal assays based on herring gulls (Larus argentatus), including one metabolite identified as 4"-OH-2,2',2",4-tetrabromo-DiPhOBz. Chemically related methoxylated tetra- to hexabromo-DiPhOBzs are known contaminants in herring gulls. Collectively, nothing is currently known about biological effects of these polybrominated (PB) DiPhOBz-based compounds...
December 28, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29273014/-hypothyroidism-screening-during-first-trimester-of-pregnancy
#17
María Castillo Lara, Ángel Vilar Sánchez, Consuelo Cañavate Solano, Estefanía Soto Pazos, María Iglesias Álvarez, Carmen González Macías, Carmen Ayala Ortega, Luis Javier Moreno Corral, Juan Jesús Fernández Alba
BACKGROUND: Subclinical hypothyroidism is defined as an elevated thyroid-stimulating hormone level with a normal thyroxin level without signs or symptoms of hypothyroidism. Although it is well accepted that overt hypothyroidism has a deleterious impact on pregnancy, recent studies indicate that subclinical hypothyroidism may affect maternal and fetal health. Studies suggest an association between miscarriage and preterm delivery in euthyroid women positive for anti-peroxidase antibodies and/or anti-thyroglobulin antibodies...
December 22, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29262478/-clinical-characteristics-of-thyroid-hormone-resistance-syndrome-in-two-cases-with-different-subtypes
#18
H Sun, X L Chen, T Chen, H Y Wu, R R Xie, F Y Wang, X Y Wang, L Q Chen
Objective: To analyze the clinical characteristics of children with two types of thyroid hormone resistance (RTH) syndrome, and to detect the variants of thyroid hormone receptor alpha(TRα) and TRβ gene in children. Method: Two children with RTH were reported in regard to clinical manifestation, laboratory examination and genetic variants. Some related reports in literature were reviewed. Result: Case 1 was a girl, 10 years old, with thyroid enlargement for several days and without thyrotoxicosis. Laboratory work-up revealed that free thyroxine (FT(4)) was 65...
December 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29261514/association-of-prothrombotic-adipokine-plasminogen-activator-inhibitor-1-with-tsh-in-metabolic-syndrome-a-case-control-study
#19
Ashok Kumar Ahirwar, Archana Singh, Anju Jain, Kirti Kaim, Shilpa Bhardwaj, Surajeet Kumar Patra, Binita Goswami, M K Bhatnagar, Jayashree Bhattacharjee
Background Metabolic syndrome (MetS) involves a cluster of cardiovascular risk factors, including abnormal lipids, insulin resistance and hypertension. The aim of the present study is to investigate associations between thyroid profile and the pro-thrombotic mediator, plasminogen activator inhibitor-1 (PAI-1), in MetS and identify associated biochemical markers. Materials and methods The present study was a case control study and consisted of 50 diagnosed cases of MetS and 50 healthy volunteers as controls...
December 20, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29260382/the-interplay-between-epithelial-mesenchymal-transition-emt-and-the-thyroid-hormones-%C3%AE-v%C3%AE-3-axis-in-ovarian-cancer
#20
Chen Weingarten, Yonatan Jenudi, Rami Yair Tshuva, Dotan Moskovich, Adi Alfandari, Aleck Hercbergs, Paul J Davis, Martin Ellis, Osnat Ashur-Fabian
Ovarian cancer is a highly metastatic disease. The metastatic potential is enhanced by epithelial to mesenchymal transition (EMT) in which αvβ3 integrin plays a role. Thyroid hormones (L-thyroxine, T4, and 3,5,3'-triiodo-L-thyronine, T3) bind this integrin, and we hypothesized that the thyroid hormone-αvβ3 axis may be involved in EMT activity in ovarian cancer. The transcription (mRNA), protein abundance (westerns), and protein localization (fluorescence microscopy) of several EMT markers were studied in ovarian cancer cells (OVCAR-3, A2780, and SKOV-3) treated with 1 nM T3 or 100 nM T4 for 1-24 h...
December 19, 2017: Hormones & Cancer
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