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https://www.readbyqxmd.com/read/28804925/relationship-between-total-homocysteine-folic-acid-and-thyroid-hormones-in-hypothyroid-dogs
#1
M Gołyński, K Lutnicki, W Krumrych, M Szczepanik, M Gołyńska, P Wilkołek, Ł Adamek, Ł Sitkowski, Ł Kurek
BACKGROUND: Both elevated homocysteine and decreased folic acid concentrations are observed in human patients with hypothyroidism and can influence the development of numerous secondary disorders. OBJECTIVES: The aim of the study was to assess total homocysteine concentration in serum and to examine its relationship with the concentration of folic acid and thyroid hormones (tT4 and fT4). ANIMALS: Ten healthy and 19 hypothyroid client-owned dogs...
August 14, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28804715/former-very-preterm-infants-show-alterations-in-thyroid-function-at-a-preschool-age
#2
Anna Posod, Irena Odri Komazec, Ulrike Pupp Peglow, Dagmar Meraner, Elke Griesmaier, Ursula Kiechl-Kohlendorfer
Preterm birth is frequently associated with altered thyroid hormone levels in the newborn period. Recent data suggest a role of prematurity independent of birth size also in childhood thyroid dysfunction. Whether the high-risk population of former very preterm infants (VPI) is particularly susceptible to thyroid hormone alterations is currently unknown. The aim of the present study was to assess whether former VPI display changes in thyroid hormone status in comparison to term-born controls at a preschool age...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28796641/the-effect-of-thyroid-dysfunction-on-nesfatin-1-and-adiponectin-levels-in-rats
#3
Emine Atıcı, Rasim Mogulkoc, Abdulkerim Kasım Baltacı, Esma Menevse
Background Changes in thyroid hormone concentrations may affect adiponectin concentrations through various mechanisms. A molecule released primarily from the fat cells adiposities; adiponectin has important effects on the regulation of body weight. Aim The present study aimed to explore the effects of experimental thyroid dysfunction and its treatment on nesfatin-1 and adiponectin levels in rats. Methods The study included 40 adult male Sprague-Dawley rats which were grouped as follows: (1) control; (2) hypothyroidism [hypothyroidism was induced by intraperitoneal injection of 10 mg/kg/day propylthiouracil (PTU) for 3 weeks]; (3) hypothyroidism + thyroxine group [after hypothyroidism was induced by 2-week PTU injection, they were treated with high-dose L-thyroxine (1...
August 10, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28794850/dual-control-of-pituitary-thyroid-stimulating-hormone-secretion-by-thyroxine-and-triiodothyronine-in-athyreotic-patients
#4
Rudolf Hoermann, John E M Midgley, Johannes W Dietrich, Rolf Larisch
BACKGROUND: Patient responses to levothyroxine (LT4) monotherapy vary considerably. We sought to differentiate contributions of FT4 and FT3 in controlling pituitary thyroid stimulating hormone (TSH) secretion. METHODS: We retrospectively assessed the relationships between TSH and thyroid hormones in 319 patients with thyroid carcinoma through 2914 visits on various LT4 doses during follow-up for 5.5 years (median, IQR 4.2, 6.9). We also associated patient complaints with the relationships...
June 2017: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28791308/recovery-following-thyroxine-treatment-withdrawal-but-not-propylthiouracil-averts-in-vivo-and-ex-vivo-thyroxine-provoked-cardiac-complications-in-adult-fvb-n-mice
#5
Nancy S Saad, Steven J Repas, Kyle Floyd, Paul M L Janssen, Mohammad T Elnakish
Persistent cardiovascular pathology has been described in hyperthyroid patients even with effective antithyroid treatment. Here, we studied the effect of a well-known antithyroid drug, propylthiouracil (PTU; 20 mg/kg/day), on thyroxine (T4; 500 µg/kg/day)-induced increase in blood pressure (BP), cardiac hypertrophy, and altered responses of the contractile myocardium both in vivo and ex vivo after 2 weeks of treatment. Furthermore, the potential recovery through 2 weeks of T4 treatment discontinuation was also investigated...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28775130/occupational-pesticide-exposure-and-subclinical-hypothyroidism-among-male-pesticide-applicators
#6
Catherine C Lerro, Laura E Beane Freeman, Curt T DellaValle, Muhammad G Kibriya, Briseis Aschebrook-Kilfoy, Farzana Jasmine, Stella Koutros, Christine G Parks, Dale P Sandler, Michael C R Alavanja, Jonathan N Hofmann, Mary H Ward
OBJECTIVES: Animal studies suggest that exposure to pesticides may alter thyroid function; however, few epidemiologic studies have examined this association. We evaluated the relationship between individual pesticides and thyroid function in 679 men enrolled in a substudy of the Agricultural Health Study, a cohort of licensed pesticide applicators. METHODS: Self-reported lifetime pesticide use was obtained at cohort enrolment (1993-1997). Intensity-weighted lifetime days were computed for 33 pesticides, which adjusts cumulative days of pesticide use for factors that modify exposure (eg, use of personal protective equipment)...
August 3, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28772162/acute-exposure-to-tris-2-butoxyethyl-phosphate-tboep-affects-growth-and-development-of-embryo-larval-zebrafish
#7
Yiran Liu, Ding Wu, Qinglong Xu, Liqin Yu, Chunsheng Liu, Jianghua Wang
Tris (2-butoxyethyl) phosphate (TBOEP), is used as a flame retardant worldwide. It is an additive in materials and can be easily discharged into the surrounding environment. There is evidence linking TBOEP exposure to abnormal development and growth in zebrafish embryos/larvae. Here, using zebrafish embryo as a model, we investigated toxicological effects on developing zebrafish (Danio rerio) caused by TBOEP at concentrations of 0, 20, 200, 1000, 2000μg/L starting from 2h post-fertilization (hpf). Our findings revealed that TBOEP exposure caused developmental toxicity, such as malformation, growth delay and decreased heart rate in zebrafish larvae...
July 27, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28770411/effect-of-iodine-nutrition-on-pregnancy-outcomes-in-an-iodine-sufficient-area-in-china
#8
Yue Xiao, Huakun Sun, Chenyan Li, Yongze Li, Shiqiao Peng, Chenling Fan, Weiping Teng, Zhongyan Shan
Many studies focused on the association between thyroid disease and pregnancy outcomes. The present study explored the effect of iodine nutrition during the first trimester on pregnancy outcomes. One thousand five hundred sixty-nine pregnant, euthyroid women at ≤12 weeks of gestation in an iodine-sufficient area in China were recruited. According to the World Health Organization (WHO) criteria for iodine nutrition during pregnancy, participants were divided into four groups: adequate iodine (median urinary iodine concentration (UIC), 150-249 μg/L), mild deficiency (UIC, 100-150 μg/L), moderate and severe deficiency (UIC, <100 μg/L), and more than adequate and excessive (UIC, ≥250 μg/L) groups...
August 2, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28768996/functional-expression-of-organic-ion-transporters-in-astrocytes-and-their-potential-as-a-drug-target-in-the-treatment-of-central-nervous-system-diseases
#9
Tomomi Furihata, Naohiko Anzai
It has become widely acknowledged that astrocytes play essential roles in maintaining physiological central nervous system (CNS) activities. Astrocytes fulfill their roles partly through the manipulation of their plasma membrane transporter functions, and therefore these transporters have been regarded as promising drug targets for various CNS diseases. A representative example is excitatory amino acid transporter 2 (EAAT2), which works as a critical regulator of excitatory signal transduction through its glutamate uptake activity at the tripartite synapse...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28767416/effect-of-subclinical-hypothyroidism-on-the-skeletal-system-and-improvement-with-short-term-thyroxine-therapy
#10
Cuixia Gao, Yu Wang, Tingting Li, Jing Huang, Limin Tian
The purpose of the study was to observe changes in the skeletal system of rats with subclinical hypothyroidism (SCH) and to determine whether L-thyroxine (L-T4) administration suppresses those changes. Sixty male Wistar rats were randomly divided into control, SCH, and SCH+T4 groups. SCH was induced in rats by administration of methimazole (MMI), and rats in the SCH+T4 group were treated with L-T4 after 45 days of MMI administration. The SCH group had higher thyroid-stimulating hormone (TSH) level than the control and SCH+T4 groups...
July 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/28763935/parental-exposure-to-microcystin-lr-induced-thyroid-endocrine-disruption-in-zebrafish-offspring-a-transgenerational-toxicity
#11
Houcheng Cheng, Wei Yan, Qin Wu, Chunsheng Liu, Xiuying Gong, Tien-Chieh Hung, Guangyu Li
Microcystin-LR is the most poisonous and commonly encountered hepatotoxin produced by cyanobacteria in an aquatic ecosystem, and it may cause thyroid dysfunction in fish. The present study aimed to reveal the effects of transgenerational toxicity of MCLR on the thyroid endocrine system under sub-chronic exposure conditions. Adult zebrafish (F0) were exposed to environmentally relevant concentrations (1, 5 and 25 μg/L) of MCLR for 45 days. The produced F1 embryos were then tested without further MCLR treatment...
July 25, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28751735/aggregated-transthyretin-is-specifically-packaged-into-placental-nano-vesicles-in-preeclampsia
#12
Mancy Tong, Shi-Bin Cheng, Qi Chen, Joana DeSousa, Peter R Stone, Joanna L James, Lawrence W Chamley, Surendra Sharma
In preeclampsia, the serum levels of transthyretin, a carrier protein for thyroxine, are elevated. Transthyretin isolated from preeclamptic serum is also aggregated and can induce preeclampsia-like symptoms in pregnant IL10(-/-) mice. Using western blotting, immunofluorescence, ELISA and qRT-PCR, we investigated the production of transthyretin by preeclamptic placentae and whether transthyretin is carried into the maternal circulation via placental extracellular vesicles. Both total and aggregated transthyretin were present in higher levels in preeclamptic placentae compared to normotensive placentae (p < 0...
July 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28750055/longer-sleep-is-associated-with-lower-bmi-and-favorable-metabolic-profiles-in-uk-adults-findings-from-the-national-diet-and-nutrition-survey
#13
Gregory D M Potter, Janet E Cade, Laura J Hardie
Ever more evidence associates short sleep with increased risk of metabolic diseases such as obesity, which may be related to a predisposition to non-homeostatic eating. Few studies have concurrently determined associations between sleep duration and objective measures of metabolic health as well as sleep duration and diet, however. We therefore analyzed associations between sleep duration, diet and metabolic health markers in UK adults, assessing associations between sleep duration and 1) adiposity, 2) selected metabolic health markers and 3) diet, using National Diet and Nutrition Survey data...
2017: PloS One
https://www.readbyqxmd.com/read/28748990/-clinical-features-of-patients-with-basedow-graves-disease-seen-at-a-university-hospital
#14
Alejandra Lanas, Patricia Díaz, Daniela Eugenin, Franco González, Pía Cid, Francisco Cordero, Verónica Araya, Claudio Liberman, Marcela Barberan, Patricio Gac, Neil Saldías, Pedro Pineda
BACKGROUND: Basedow Graves disease (BGD) is the leading cause of hyperthyroidism. The characteristics of patients seen at a university hospital may differ from those described in the general population. AIM: To describe the clinical features of patients with BGD seen at a university hospital. MATERIAL AND METHODS: Review of medical records of all patients seen at our hospital between 2009 and 2014 with the diagnosis of thyrotoxicosis, hyperthyroidism or BGD...
April 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28747386/the-association-of-autoimmune-thyroid-disease-aitd-with-psoriatic-disease-a-prospective-cohort-study-systematic-review-and-meta-analysis
#15
Samer R Khan, Arjola Bano, Marlies Wakkee, Tim Korevaar, Oscar Franco, Tamar Nijsten, Robin P Peeters, L Chaker
Objective Autoimmune thyroid disease (AITD) and psoriatic disease share auto-immunological components. Few studies have investigated the link between both, yielding inconclusive results. Design We assessed the association of AITD with psoriatic disease in a prospective cohort study, and performed a systematic review and meta-analysis. Methods 8,214 participants of the Rotterdam Study (RS) with thyroid peroxidase antibodies (TPO-Abs), thyroid stimulating hormone (TSH) and/or free thyroxine (FT4) measurements and information on psoriatic disease were included...
July 26, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28741453/no-effect-of-levothyroxine-and-levothyroxine-induced-subclinical-thyrotoxicosis-on-the-pharmacokinetics-of-sorafenib-in-healthy-male-subjects
#16
Funan Huang, Antoinette Ajavon-Hartmann, Erya Huang, John Lettieri, Rong Liu, Carol Pena, Matthias Berse
<b>Background</b>: Patients receiving the multikinase inhibitor sorafenib for locally recurrent or metastatic, progressive, differentiated thyroid carcinoma (DTC) refractory to radioactive iodine often receive concomitant levothyroxine for thyroid-stimulating hormone (TSH) suppression. In the phase 3 DTC trial (DECISION), sorafenib exposure was ~2-fold higher than that observed in other cancers. We assessed sorafenib pharmacokinetics without and with concomitant levothyroxine to examine whether a levothyroxine interaction or levothyroxine-induced subclinical thyrotoxicosis results in increased sorafenib exposure in DTC patients...
July 25, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28736927/pituitary-thyroid-axis-development-during-the-larval-juvenile-transition-in-the-pejerrey-odontesthes-bonariensis
#17
T Chalde, L A Miranda
The morphological development of the thyroid gland of pejerrey Odontesthes bonariensis during larval-juvenile transition was studied and related to whole-body concentrations of thyroxine (T4 ) and tri-iodothyronine (T3 ). A complementary (c)DNA fragment of the thyroid-stimulating hormone β-subunit (tshb) was sequenced and transcript levels quantified during this period. Follicles with eosinophilic and T4 -immunoreactive colloids were detected at hatching together with tshb transcript levels and whole-body concentrations of T4 and T3 hormones...
July 23, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/28727687/hippocampus-dependent-memory-and-allele-specific-gene-expression-in-adult-offspring-of-alcohol-consuming-dams-after-neonatal-treatment-with-thyroxin-or-metformin
#18
E Tunc-Ozcan, S L Wert, P H Lim, A Ferreira, E E Redei
Fetal alcohol spectrum disorder (FASD), the result of fetal alcohol exposure (FAE), affects 2-11% of children worldwide, with no effective treatments. Hippocampus-based learning and memory deficits are key symptoms of FASD. Our previous studies show hypothyroxinemia and hyperglycemia of the alcohol-consuming pregnant rat, which likely affects fetal neurodevelopment. We administered vehicle, thyroxine (T4) or metformin to neonatal rats post FAE and rats were tested in the hippocampus-dependent contextual fear-conditioning paradigm in adulthood...
July 20, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28725979/effect-of-weight-loss-after-bariatric-surgery-on-thyroid-stimulating-hormone-levels-in-patients-with-morbid-obesity-and-normal-thyroid-function
#19
João Sérgio Neves, Sofia Castro Oliveira, Pedro Souteiro, Jorge Pedro, Daniela Magalhães, Vanessa Guerreiro, Rita Bettencourt-Silva, Maria Manuel Costa, Ana Cristina Santos, Joana Queirós, Ana Varela, Paula Freitas, Davide Carvalho
BACKGROUND: Several studies have reported that morbid obesity is associated with increased thyroid-stimulating hormone (TSH) levels. However, it is not clear what is the impact of bariatric surgery on postoperative thyroid function. The aim of this study was to evaluate the effect of weight loss after bariatric surgery on TSH levels in euthyroid patients with morbid obesity. METHODS: We performed a retrospective observational study of 949 euthyroid patients (86...
July 19, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28721126/the-thyroid-gland-in-postmenopausal-women-physiology-and-diseases
#20
REVIEW
Małgorzata Gietka-Czernel
The incidence of most thyroid diseases: hypothyroidism, nodular goitre, and cancer is highest among postmenopausal and elderly women. The diagnosis of thyroid dysfunction in this group of patients is difficult because the symptoms can be nonspecific or common with menopausal and ageing complaints. In the interpretation of thyroid function tests the physiological changes in secretion and metabolism of thyrotropin (TSH) and thyroid hormones must be considered, as well as the influence of comorbidities. Unrecognised thyroid dysfunction leads to increased: cardiovascular risk, bone fractures, cognitive impairment, depression, and mortality...
June 2017: Przeglad Menopauzalny, Menopause Review
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