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https://www.readbyqxmd.com/read/27718637/new-levothyroxine-formulation-meeting-95-105-specification-over-the-whole-shelf-life-results-from-two-pharmacokinetic-trials
#1
Ulrike Gottwald-Hostalek, Wolfgang Uhl, Peter Wolna, George J Kahaly
OBJECTIVE: Small levothyroxine (L-T4) dose changes can lead to significant clinical effects. To ensure thyroid hormone levels are safely maintained, authorities are increasingly adopting stricter potency specifications for L-T4, the most stringent of these being 95-105% of the labeled dose over the whole shelf-life. Levothyroxine sodium (Euthyrox®, Eutirox®, Lévothyrox®) has been reformulated, and two studies performed to ensure bioequivalence to the currently marketed formulation and dosage form proportionality of the new formulation...
October 8, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/18578649/high-altitude-pulmonary-edema-down-syndrome-and-obstructive-sleep-apneas
#2
Jean-Paul Richalet, Cécile Chenivesse, Philippe Larmignat, Laurent Meille
A 24-year-old adult with a Down syndrome was admitted in December 2006 at the Moutiers hospital in the French Alps for an acute inaugural episode of high altitude pulmonary edema (HAPE) that occurred in the early morning of day 3 after his arrival to La Plagne (2000 m). This patient presented an interventricular septal defect operated on at the age of 7, a hypothyroidism controlled by 50 microg levothyrox, a state of obesity (BMI 37.8 kg/m(2)), and obstructive sleep apneas with a mean of 42 obstructive apneas or hypopneas per hour, treated with continuous positive airway pressure (CPAP)...
2008: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/16829476/-central-hypothyroidism-associated-with-bexarotene-therapy
#3
C Martin, K Bach-Ngohou, B Perrin, D Masson
We report the case of a patient with cutaneous T-cell lymphoma treated by bexaroten Targretin, a synthetic retinoid analog with specific affinity for retinoid X receptor. The treatment induced mixed hyperlipidemia and severe central hypothyroidism characterized by reduced TSH and thyroxine serum levels. Only the pituitary thyreotrope function was affected. Targretin therapy can be maintained. Adverse drug events may be managed by fenofibrate Lipanthyl for dyslipidemia and high dose L-thyroxin Lévothyrox requiring serum free thyroxin level measurement for central hypothyroidism...
July 2006: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/3911524/-clinical-trial-of-levothyrox-50-in-the-treatment-of-hypothyroidism
#4
F Ben Khalifa, N Ben Abdallah, S Sellami, K el Ach, S Jedidi, H Ben Ayed
No abstract text is available yet for this article.
August 1985: La Tunisie Médicale
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