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https://www.readbyqxmd.com/read/28106904/planned-early-delivery-versus-expectant-management-for-hypertensive-disorders-from-34-weeks-gestation-to-term
#1
REVIEW
Catherine Cluver, Natalia Novikova, Corine M Koopmans, Helen M West
BACKGROUND: Hypertensive disorders in pregnancy are significant contributors to maternal and perinatal morbidity and mortality. These disorders include well-controlled chronic hypertension, gestational hypertension (pregnancy-induced hypertension) and mild pre-eclampsia. The definitive treatment for these disorders is planned early delivery and the alternative is to manage the pregnancy expectantly if severe uncontrolled hypertension is not present, with close maternal and fetal monitoring...
January 15, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28099980/challenges-faced-in-translating-the-benefits-of-surfactant-replacement-therapy-to-a-resource-limited-setting
#2
N Hamilton, Helen Trotman
Aim To determine the challenges, if any, in translating the benefits of surfactant replacement therapy (SRT) to a resource-limited setting. Method This was a retrospective descriptive study comparing the outcome of 75 cases who received surfactant and 69 controls who did not at the University Hospital of the West Indies during the period 2001 to 2011. Descriptive analyses were performed. Statistical significance was taken at the level p < 0.05. Results Only 13% of neonates with respiratory distress syndrome received surfactant therapy...
January 18, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28069378/role-of-n-glycosylation-on-zika-virus-e-protein-secretion-viral-assembly-and-infectivity
#3
M Mossenta, S Marchese, M Poggianella, J L Slon Campos, O R Burrone
Zika virus has rapidly spread reaching a global distribution pattern similar to that of dengue virus, and has been associated with serious neurological and developmental pathologies, like congenital malformation during pregnancy and Guillain-Barré syndrome. Sequence analysis of different clinical and laboratory isolates has shown the existence of mutants with loss of the conserved N-glycosylation motif on domain I of protein E that is common to all flaviviruses. We found that loss of E N-linked glycosylation leads to compromised expression and secretion of E ectodomain from mammalian cells...
January 6, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28065618/pathological-features-and-clinical-behavior-of-lynch-syndrome-associated-ovarian-cancer
#4
N A J Ryan, D G Evans, K Green, E J Crosbie
OBJECTIVE: Lynch syndrome (LS) is an inherited tumor predisposition condition caused by mutations in the mismatch repair (MMR) genes. Mutation carriers are at increased risk of various malignancies, including ovarian cancer (OC). Relatively little is known about the pathological features and clinical behavior of LS associated OC. METHODS: We analyzed the data of 1047 proven MMR mutated individuals from a prospectively maintained database at a large referral center for genomic medicine in the North West of England...
January 5, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28063258/eating-attitudes-and-its-relationship-with-nutritional-status-a-micro-level-study-on-a-group-of-adolescent-girls-in-the-city-of-howrah-west-bengal
#5
Nadira Mallick, Susmita Mukhopadhyay, Subha Ray
BACKGROUND: To assess the relationship between eating attitudes and nutritional status. METHODS: This cross-sectional study was conducted among 400 adolescent girls (258 aged 14-17 years and 142 aged 18-21 years) from the city of Howrah, West Bengal. Eating attitude was measured using eating distress syndrome (EDS) questionnaire. Nutritional status was assessed using body mass index, waist-hip ratio (WHR) and body fat percentage (BF%). RESULTS: Participants with disordered eating attitudes revealed significantly higher values for body mass index (BMI), WHR and BF% than those with normal eating attitudes (p≤0...
January 7, 2017: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/28061903/detection-of-west-nile-virus-in-six-mosquito-species-in-synchrony-with-seroconversion-among-sentinel-chickens-in-india
#6
Siraj A Khan, Purvita Chowdhury, Parveena Choudhury, Prafulla Dutta
BACKGROUND: West Nile virus (WNV) is a zoonotic flavivirus maintained in mosquito-bird transmission cycle. Although humans are accidental hosts, fatal outcomes following WNV infection have been reported from India. Studies have identified WNV as an important etiological agent causing acute encephalitis syndrome in Assam, Northeast India. While circulation of WNV is evident, the role of vectors and avian hosts involved in the transmission remains unclear. In this study we identified local mosquito species for evidence of WNV infection along with seroconversion among sentinel chickens...
January 7, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28053010/mutations-in-gabrb3-from-febrile-seizures-to-epileptic-encephalopathies
#7
Rikke S Møller, Thomas V Wuttke, Ingo Helbig, Carla Marini, Katrine M Johannesen, Eva H Brilstra, Ulvi Vaher, Ingo Borggraefe, Inga Talvik, Tiina Talvik, Gerhard Kluger, Laurence L Francois, Gaetan Lesca, Julitta de Bellescize, Susanne Blichfeldt, Nicolas Chatron, Nils Holert, Julia Jacobs, Marielle Swinkels, Cornelia Betzler, Steffen Syrbe, Marina Nikanorova, Candace T Myers, Line H G Larsen, Sabina Vejzovic, Manuela Pendziwiat, Sarah von Spiczak, Sarah Hopkins, Holly Dubbs, Yuan Mang, Konstantin Mukhin, Hans Holthausen, Koen L van Gassen, Hans A Dahl, Niels Tommerup, Heather C Mefford, Guido Rubboli, Renzo Guerrini, Johannes R Lemke, Holger Lerche, Hiltrud Muhle, Snezana Maljevic
OBJECTIVE: To examine the role of mutations in GABRB3 encoding the β3 subunit of the GABAA receptor in individual patients with epilepsy with regard to causality, the spectrum of genetic variants, their pathophysiology, and associated phenotypes. METHODS: We performed massive parallel sequencing of GABRB3 in 416 patients with a range of epileptic encephalopathies and childhood-onset epilepsies and recruited additional patients with epilepsy with GABRB3 mutations from other research and diagnostic programs...
January 4, 2017: Neurology
https://www.readbyqxmd.com/read/28031324/overweight-and-obese-but-not-normal-weight-women-with-pcos-are-at-increased-risk-of-type-2-diabetes-mellitus-a-prospective-population-based-cohort-study
#8
M-M E Ollila, S West, S Keinänen-Kiukaanniemi, J Jokelainen, J Auvinen, K Puukka, A Ruokonen, M-R Järvelin, J S Tapanainen, S Franks, T T Piltonen, L C Morin-Papunen
STUDY QUESTION: What are the respective roles of polycystic ovary syndrome (PCOS), long-term weight gain and obesity for the development of prediabetes or Type 2 diabetes mellitus (T2DM) by age 46 years? SUMMARY ANSWER: The risk of T2DM in women with PCOS is mainly due to overweight and obesity, although these two factors have a synergistic effect on the development of T2DM. WHAT IS KNOWN ALREADY: PCOS is associated with an increased risk of prediabetes and T2DM...
December 28, 2016: Human Reproduction
https://www.readbyqxmd.com/read/28028820/risk-factors-for-mortality-in-patients-with-anti-nmda-receptor-encephalitis
#9
X Chi, W Wang, C Huang, M Wu, L Zhang, J Li, D Zhou
OBJECTIVE: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe autoimmune disorder with a mortality of 5%-7%, but few studies have focused on the predictors of death in this disease. In this study, we aim to investigate predictors and causes of death in patients with anti-NMDAR encephalitis. METHODS: In this cohort study, patients with anti-NMDAR encephalitis were enrolled at the West China Hospital of Sichuan University between June 2011 and October 2015...
December 27, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28027587/analysis-of-surgical-interruption-of-the-enterohepatic-circulation-as-a-treatment-for-pediatric-cholestasis
#10
Kasper S Wang, Greg Tiao, Lee M Bass, Paula M Hertel, Douglas Mogul, Nanda Kerkar, Matthew Clifton, Colleen Azen, Laura Bull, Philip Rosenthal, Dylan Stewart, Riccardo Superina, Ronen Arnon, Molly Bozic, Mary L Brandt, Patrick A Dillon, Annie Fecteau, Kishore Iyer, Binita Kamath, Saul Karpen, Frederick Karrer, Kathleen M Loomes, Cara Mack, Peter Mattei, Alexander Miethke, Kyle Soltys, Yumirle P Turmelle, Karen West, Jessica Zagory, Cat Goodhue, Benjamin L Shneider
: To evaluate the efficacy of non-transplant surgery for pediatric cholestasis, 58 clinically diagnosed children, including 20 Alagille syndrome (ALGS), 16 Familial Intrahepatic Cholestasis-1 (FIC1), 18 Bile Salt Export Pump (BSEP) disease, & 4 others with low γ-glutamyl transpeptidase disease (levels <100 U/L), were identified across 14 Childhood Liver Disease Research Network (ChiLDReN) centers. Data were collected retrospectively from individuals who collectively had 39 partial external biliary diversions (PEBD), 11 ileal exclusions (IE) and 7 gallbladder-to-colon diversion (GBC)...
December 27, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28012878/viral-posterior-uveitis
#11
REVIEW
Joanne H Lee, Aniruddha Agarwal, Padmamalini Mahendradas, Cecilia S Lee, Vishali Gupta, Carlos E Pavesio, Rupesh Agrawal
The causes of posterior uveitis can be divided into infectious, autoimmune, or masquerade syndromes. Viral infections. a significant cause of sight-threatening ocular diseases in the posterior segment,, include human herpesviruses, measles, rubella, and arboviruses such as dengue, West Nile, and chikungunya virus. Viral posterior uveitis may occur as an isolated ocular disease in congenital or acquired infections or as part of a systemic viral illness. Many viruses remain latent in the infected host with a risk of reactivation that depends on various factors, including virulence and host immunity, age, and comorbidities...
December 21, 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28011231/metabolic-syndrome-and-occupation-any-association-prevalence-among-auto-technicians-and-school-teachers-in-south-west-nigeria
#12
Adeseye A Akintunde, Taiwo W Oloyede
AIMS: To determine occupational association with metabolic syndrome among auto technicians and school teachers. METHODS: One hundred and sixty six subjects were selected for this study. Clinical data was obtained while laboratory investigations including plasma glucose and lipid profile were performed. Statistical analysis was done with SPSS 20.0. P<0.05 was taken as statistically significant. RESULTS: School teachers had significantly higher mean total cholesterol and LDL-cholesterol compared to auto technicians...
December 14, 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28006043/health-care-resource-use-in-patients-with-and-without-22q11-2-deletion-syndrome-undergoing-sphincter-pharyngoplasty-for-velopharyngeal-insufficiency
#13
Darrell T Wright, Shaun A Nguyen, Ronald J Teufel, David R White
Importance: The use of health care resources in patients with velopharyngeal insufficiency undergoing sphincter pharyngoplasty is unknown. Objectives: To examine the use of health care resources by patients with velopharyngeal insufficiency who have undergone sphincter pharyngoplasty and investigate whether patients with 22q11.2 deletion syndrome (22qDS) had a longer length of stay, increased cost of admission, and higher number of complications. Design, Setting, and Participants: Using data from the Kids' Inpatient Database for January 1 to December 31, 2012, we retrospectively analyzed all patients undergoing pharyngoplasty for velopharyngeal insufficiency...
December 22, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28005049/-hormonal-treatment-in-west-syndrome
#14
E D Belousova, I V Shulyakova, T G Okhapkina
West syndrome is one of the most well-known epileptic encephalopathies, a catastrophic epilepsy syndrome with onset in the first year of life. Prognosis of this condition depends on the etiology and adequate treatment. The authors review the hormonal treatment of West syndrome. Adrenocorticotrophic hormone (ACTH) is used in USA and its synthetic analogue tetracosactide is used in Europe. Both of the drugs are not registered in the Russian Federation. The data on the efficacy of corticosteroids, including prednisolone, are contradictory...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28000331/exploring-the-potential-role-of-the-advanced-nurse-practitioner-within-a-care-path-for-patients-with-chronic-fatigue-syndrome
#15
Hannah Ryckeghem, Liesbeth Delesie, Els Tobback, Stefaan Lievens, Dirk Vogelaers, An Mariman
AIMS: To explore the experiences and expectations of patients with chronic fatigue syndrome and general practitioners to develop the potential role of an advanced nurse practitioner at the diagnostic care path of abnormal fatigue developed for regional transmural implementation in the Belgian provinces of East and West Flanders. BACKGROUND: Patients with chronic fatigue syndrome experience an incapacitating chronic fatigue that is present for at least 6 months. Since many uncertainties exist about the causes and progression of the disease, patients have to cope with disbelief and scepticism...
December 21, 2016: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/27994368/efficacy-and-tolerability-of-the-modified-atkins-diet-in-young-children-with-refractory-epilepsy-indian-experience
#16
Ranju Mehta, Shaiphali Goel, Suvasini Sharma, Puneet Jain, Sharmila B Mukherjee, Satinder Aneja
BACKGROUND: The modified Atkins diet (MAD) has been used predominantly in older children, adolescents, and adults. There is a paucity of data on the use of the MAD in refractory epilepsy in young children. OBJECTIVES: This study was planned to evaluate the efficacy and tolerability of the MAD in refractory epilepsy in young children. METHODS: This study recruited children aged 9 months to 3 years with refractory seizures. Children received MAD for 6-month with the on-going anticonvulsant medications being continued unchanged...
October 2016: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/27994096/paediatric-rheumatology-clinic-population-in-southeast-asia-are-we-different
#17
Thaschawee Arkachaisri, Swee-Ping Tang, Tassalapa Daengsuwan, Gun Phongsamart, Soamarat Vilaiyuk, Sirirat Charuvanij, Sook Fun Hoh, Justin Hung Tiong Tan, Lena Das, Elizabeth Ang, Wendy Lim, Yiong Huak Chan, Christine B Bernal
OBJECTIVES: To examine the descriptive epidemiology of the patient population referred to paediatric rheumatology centres (PRCs) in Southeast Asia (SEA) and to compare the frequency of conditions encountered with other PRC populations. METHODS: A web-based Registry for Childhood Onset Paediatric Rheumatic Diseases was established in 2009 and seven PRCs in four SEA countries, where paediatric rheumatologists are available, participated in a prospective 24 month data collection (43 months for Singapore)...
December 19, 2016: Rheumatology
https://www.readbyqxmd.com/read/27990674/nationwide-survey-of-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-in-children-in-the-united-states
#18
Yusuke Okubo, Kotaro Nochioka, Marcia A Testa
Although Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are serious, life-threatening reactions to drug therapies, no efforts have been made to investigate the comprehensive change in epidemiology with respect to age, sex, and race and ethnicity in children. The risk of death was 0.3% to 1.5%, and the highest hospitalization rates were in children 15 to 19 years of age, boys, and black children. The highest proportions of hospitalizations were children with very low household income, those with private insurance, and those treated at large urban teaching hospitals in the West...
December 19, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27938434/early-detection-of-west-nile-virus-in-france-quantitative-assessment-of-syndromic-surveillance-system-using-nervous-signs-in-horses
#19
C Faverjon, F Vial, M G Andersson, S Lecollinet, A Leblond
West Nile virus (WNV) is a growing public health concern in Europe and there is a need to develop more efficient early detection systems. Nervous signs in horses are considered to be an early indicator of WNV and, using them in a syndromic surveillance system, might be relevant. In our study, we assessed whether or not data collected by the passive French surveillance system for the surveillance of equine diseases can be used routinely for the detection of WNV. We tested several pre-processing methods and detection algorithms based on regression...
December 12, 2016: Epidemiology and Infection
https://www.readbyqxmd.com/read/27929218/emerging-vector-borne-diseases
#20
Mark K Huntington, Jay Allison, Dilip Nair
Several mosquito-borne viral infections have recently emerged in North America; West Nile virus is the most common in the United States. Although West Nile virus generally causes a self-limited, flulike febrile illness, a serious neuroinvasive form may occur. Dengue is the most common vector-borne viral disease worldwide, and it has been a significant public health threat in the United States since 2009. Known as breakbone fever for its severe myalgias and arthralgias, dengue may cause a hemorrhagic syndrome...
October 1, 2016: American Family Physician
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