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https://www.readbyqxmd.com/read/29142097/fast-oscillation-dynamics-during-hypsarrhythmia-as-a-localization-biomarker
#1
Min-Jee Kim, Mi-Sun Yum, Hye-Ryun Yeh, Tae-Sung Ko
Hypsarrhythmia in West syndrome, although hard to define, is characterized by chaotic and disorganized electrical activity of the brain and is often regarded as a generalized EEG pattern without any localization value. Using event-related spectral perturbation (ERSP), we tried to determine the brain dynamics during hypsarrhythmia. Routine 1-h scalp EEGs were retrieved from 31 patients with infantile spasms and 20 age-matched controls. Using the EEGLAB toolbox of MATLAB 2015b, the ERSPs of fast oscillations (FOs; 20-100 Hz) of selected channels were analyzed and compared among groups according to their MRI lesions...
November 15, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29141310/-analysis-of-gene-mutation-of-early-onset-epileptic-spasm-with-unknown-reason
#2
X Yang, G Pan, W H Li, L M Zhang, B B Wu, H J Wang, P Zhang, S Z Zhou
Objective: To summarize the gene mutation of early onset epileptic spasm with unknown reason. Method: In this prospective study, data of patients with early onset epileptic spasm with unknown reason were collected from neurological department of Children's Hospital of Fudan University between March 2016 and December 2016. Patients with known disorders such as infection, metabolic, structural, immunological problems and known genetic mutations were excluded. Patients with genetic disease that can be diagnosed by clinical manifestations and phenotypic characteristics were also excluded...
November 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29138586/association-between-metabolic-syndrome-and-sensorineural-hearing-loss-a-cross-sectional-study-of-11-114-participants
#3
Javad Aghazadeh-Attari, Behnam Mansorian, Mohammad Mirza-Aghazadeh-Attari, Jamal Ahmadzadeh, Iraj Mohebbi
Background/objectives: Hearing loss (HL) is associated with certain diseases and affects health, resulting in a low quality of life. Some components of the metabolic syndrome (MetS) coincide with the risk factors for sensorineural hearing loss (SNHL). To date, very few studies have examined the link between MetS and HL. The aim of the current study was to try to understand the potential association between MetS and HL. Methods: Using Iranian health surveys of professional drivers, we enrolled 11,114 individuals aged 20-60 years, whose main job is to operate a motor vehicle...
2017: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/29131802/acute-and-one-year-clinical-outcomes-following-implantation-of-bioresorbable-vascular-scaffolds-the-absorb-uk-registry
#4
Andreas Baumbach, Azfar Zaman, Nick Ej West, Peter O'Kane, Mohaned Egred, Thomas Johnson, Stephen Wheatcroft, Bowles Ruth, Adam de Belder, Georgious Bouras, Alexandra Lansky, Jonathan Hill, Anthony Mathur, Mark A de Belder, Adrian Banning
AIMS: The aim was to monitor practice patterns and outcomes in patients treated with Absorb bioresorbable vascular scaffolds (BVS) during the early phase of usage in the UK. METHODS AND RESULTS: A total of 1005 patients with de-novo coronary lesions were treated using careful implantation techniques at 24 centers. Follow-up at one year was obtained in 99%. An independent clinical event committee and angiographic corelab adjudicated all events. Patient age was 52 years and 46% presented with acute coronary syndromes...
November 14, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29126048/lennox-gastaut-syndrome-in-adulthood-long-term-clinical-follow-up-of-38-patients-and-analysis-of-their-recorded-seizures
#5
Aglaia Vignoli, Gaia Oggioni, Giovanni De Maria, Angela Peron, Miriam Nella Savini, Elena Zambrelli, Valentina Chiesa, Francesca La Briola, Katherine Turner, Maria Paola Canevini
Lennox-Gastaut syndrome (LGS) is a severe epileptic encephalopathy with childhood onset that usually continues through adolescence and into adulthood. In the long term, patients with this condition still have intractable seizures, intellectual disability, behavioral problems, and physical comorbidities. The aim of this study was to describe the clinical and EEG characteristics of a group of adults with Lennox-Gastaut syndrome. We identified 38 (22 females, 16 males) patients with LGS older than age 18years at their last evaluation, with mean age of 43...
November 7, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29118054/vitamin-d-status-in-chronic-fatigue-syndrome-myalgic-encephalomyelitis-a-cohort-study-from-the-north-west-of-england
#6
Kate E Earl, Giorgos K Sakellariou, Melanie Sinclair, Manuel Fenech, Fiona Croden, Daniel J Owens, Jonathan Tang, Alastair Miller, Clare Lawton, Louise Dye, Graeme L Close, William D Fraser, Anne McArdle, Michael B J Beadsworth
OBJECTIVE: Severe vitamin D deficiency is a recognised cause of skeletal muscle fatigue and myopathy. The aim of this study was to examine whether chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is associated with altered circulating vitamin D metabolites. DESIGN: Cohort study. SETTING: UK university hospital, recruiting from April 2014 to April 2015. PARTICIPANTS: Ninety-two patients with CFS/ME and 94 age-matched healthy controls (HCs)...
November 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/29096625/frequency-patterns-of-core-constipation-symptoms-among-the-asian-adults-a-systematic-review
#7
Abdul Wahab Patimah, Yeong Yeh Lee, Mohd Yusoff Dariah
BACKGROUND: In clinical practice, assessment of constipation depends on reliability, consistency and frequency of several commonly reported or core symptoms. It is not known if frequency patterns of constipation symptoms in adults are different between the West and the East. This review aimed to describe core constipation symptoms and their frequency patterns among the Asian adults. METHODS: Articles published in PubMed, MEDLINE, CINAHL and Science Direct from 2005 to 2015 were searched systematically...
November 2, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29062978/interneuronopathies-and-their-role-in-early-life-epilepsies-and-neurodevelopmental-disorders
#8
Anna-Maria Katsarou, Solomon L Moshé, Aristea S Galanopoulou
GABAergic interneurons control the neural circuitry and network activity in the brain. The advances in genetics have identified genes that control the development, maturation and integration of GABAergic interneurons and implicated them in the pathogenesis of epileptic encephalopathies or neurodevelopmental disorders. For example, mutations of the Aristaless-Related homeobox X-linked gene (ARX) may result in defective GABAergic interneuronal migration in infants with epileptic encephalopathies like West syndrome (WS), Ohtahara syndrome or X-linked lissencephaly with abnormal genitalia (XLAG)...
September 2017: Epilepsia open
https://www.readbyqxmd.com/read/29053119/-peptidergic-nootropic-therapy-in-cerebral-palsy-associated-with-epilepsy
#9
A A Kholin, N N Zavadenko, E S Il Ina, L M Kolpakchi, I D Fedonyuk, R C Bembeeva, E S Esipova
AIM: To assess the efficacy and safety of сortexin in the treatment of children with cerebral palsy (CP) combined with epilepsy. MATERIAL AND METHODS: Eighty-four patients (55 boys and 29 girls), aged from 1 to 11 years, with CP combined with epilepsy received cortexin together with antiepileptic drugs (AEDs). Cortexin was administered in doses of 5-10 mg depending on the patient's age and body weight intramuscularly during hospitalization. RESULTS AND CONCLUSION: Cortexin as add-on to AEDs reduced for more than two times the number of seizures, along with improvement of motor function, in 31 (36...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29050398/delineating-sptan1-associated-phenotypes-from-isolated-epilepsy-to-encephalopathy-with-progressive-brain-atrophy
#10
Steffen Syrbe, Frederike L Harms, Elena Parrini, Martino Montomoli, Ulrike Mütze, Katherine L Helbig, Tilman Polster, Beate Albrecht, Ulrich Bernbeck, Ellen van Binsbergen, Saskia Biskup, Lydie Burglen, Jonas Denecke, Bénédicte Heron, Henrike O Heyne, Georg F Hoffmann, Frauke Hornemann, Takeshi Matsushige, Ryuki Matsuura, Mitsuhiro Kato, G Christoph Korenke, Alma Kuechler, Constanze Lämmer, Andreas Merkenschlager, Cyril Mignot, Susanne Ruf, Mitsuko Nakashima, Hirotomo Saitsu, Hannah Stamberger, Tiziana Pisano, Jun Tohyama, Sarah Weckhuysen, Wendy Werckx, Julia Wickert, Francesco Mari, Nienke E Verbeek, Rikke S Møller, Bobby Koeleman, Naomichi Matsumoto, William B Dobyns, Domenica Battaglia, Johannes R Lemke, Kerstin Kutsche, Renzo Guerrini
De novo in-frame deletions and duplications in the SPTAN1 gene, encoding the non-erythrocyte αII spectrin, have been associated with severe West syndrome with hypomyelination and pontocerebellar atrophy. We aimed at comprehensively delineating the phenotypic spectrum associated with SPTAN1 mutations. Using different molecular genetic techniques, we identified 20 patients with a pathogenic or likely pathogenic SPTAN1 variant and reviewed their clinical, genetic and imaging data. SPTAN1 de novo alterations included seven unique missense variants and nine in-frame deletions/duplications of which 12 were novel...
September 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29037205/vildagliptin-ameliorates-pulmonary-fibrosis-in-lipopolysaccharide-induced-lung-injury-by-inhibiting-endothelial-to-mesenchymal-transition
#11
Toshio Suzuki, Yuji Tada, Santhi Gladson, Rintaro Nishimura, Iwao Shimomura, Satoshi Karasawa, Koichiro Tatsumi, James West
BACKGROUND: Pulmonary fibrosis is a late manifestation of acute respiratory distress syndrome (ARDS). Sepsis is a major cause of ARDS, and its pathogenesis includes endotoxin-induced vascular injury. Recently, endothelial-to-mesenchymal transition (EndMT) was shown to play an important role in pulmonary fibrosis. On the other hand, dipeptidyl peptidase (DPP)-4 was reported to improve vascular dysfunction in an experimental sepsis model, although whether DPP-4 affects EndMT and fibrosis initiation during lipopolysaccharide (LPS)-induced lung injury is unclear...
October 16, 2017: Respiratory Research
https://www.readbyqxmd.com/read/29026089/a-large-scale-hearing-loss-screen-reveals-an-extensive-unexplored-genetic-landscape-for-auditory-dysfunction
#12
Michael R Bowl, Michelle M Simon, Neil J Ingham, Simon Greenaway, Luis Santos, Heather Cater, Sarah Taylor, Jeremy Mason, Natalja Kurbatova, Selina Pearson, Lynette R Bower, Dave A Clary, Hamid Meziane, Patrick Reilly, Osamu Minowa, Lois Kelsey, Glauco P Tocchini-Valentini, Xiang Gao, Allan Bradley, William C Skarnes, Mark Moore, Arthur L Beaudet, Monica J Justice, John Seavitt, Mary E Dickinson, Wolfgang Wurst, Martin Hrabe de Angelis, Yann Herault, Shigeharu Wakana, Lauryl M J Nutter, Ann M Flenniken, Colin McKerlie, Stephen A Murray, Karen L Svenson, Robert E Braun, David B West, K C Kent Lloyd, David J Adams, Jacqui White, Natasha Karp, Paul Flicek, Damian Smedley, Terrence F Meehan, Helen E Parkinson, Lydia M Teboul, Sara Wells, Karen P Steel, Ann-Marie Mallon, Steve D M Brown
The developmental and physiological complexity of the auditory system is likely reflected in the underlying set of genes involved in auditory function. In humans, over 150 non-syndromic loci have been identified, and there are more than 400 human genetic syndromes with a hearing loss component. Over 100 non-syndromic hearing loss genes have been identified in mouse and human, but we remain ignorant of the full extent of the genetic landscape involved in auditory dysfunction. As part of the International Mouse Phenotyping Consortium, we undertook a hearing loss screen in a cohort of 3006 mouse knockout strains...
October 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/29019977/neurobiology-domains-to-the-rescue-for-rett-syndrome
#13
Anne E West
No abstract text is available yet for this article.
October 11, 2017: Nature
https://www.readbyqxmd.com/read/28980935/lactobacillus-acidophilus-versus-placebo-in-the-symptomatic-treatment-of-irritable-bowel-syndrome-the-lapibss-randomized-trial
#14
S Sadrin, S R Sennoune, B Gout, S Marque, J Moreau, J Grillasca, O Pons, J M Maixent
Irritable bowel syndrome is a chronic functional gastrointestinal disorder characterized by abdominal pain/discomfort and altered bowel habits. The use of Lactobacilli as probiotics during irritable bowel syndrome is based on their interesting mechanisms of action and their excellent safety profile but little is known about their clinical efficacy due to the lack of adequately designed clinical trials. The current clinical trial protocol aims to determine the effects of a mixture of Lactobacillus acidophilus NCFM and LAFTI L10 as probiotics to improve irritable bowel syndrome symptoms (LAPIBSS)...
September 30, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28980750/computer-vision-syndrome-and-ergonomic-practices-among-undergraduate-university-students
#15
Lizette Mowatt, Carron Gordon, Arvind Babu Rajendra Santosh, Thaon Jones
AIM: To determine the prevalence of computer vision syndrome (CVS) and ergonomic practices among students in the Faculty of Medical Sciences at The University of the West Indies (UWI), Jamaica. METHOD: A cross-sectional study was done with a self-administered questionnaire. RESULTS: Four hundred and nine students participated; 78% were females. The mean age was 21.6 years. Neck pain (75.1%), eye strain (67%), shoulder pain (65.5%) and eye burn (61...
October 5, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28979009/scrub-typhus-an-emerging-threat
#16
Sayantani Chakraborty, Nilendu Sarma
Scrub typhus is caused by Orientia tsutsugamushi (formerly Rickettsia) and is transmitted to humans by an arthropod vector of the Trombiculidae family (Leptotrombidium deliense and L. akamushi). It is the most common re-emerging Rickettsial infection in India and many other South East Asian countries. In fact, scrub typhus is confined geographically to the Asia Pacific region, a billion people are at risk and nearly a million cases are reported every year. Scrub typhus appears particularly to be distributed in the tsutsugamushi triangle which is distributed over a very wide area of 13 million km(2) bound by Japan in the east, through China, the Philippines, tropical Australia in the south, and west through India, Pakistan, possibly to Tibet to Afghanistan, and southern parts of the USSR in the north...
September 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28973655/clinical-and-molecular-features-of-renal-and-pheochromocytoma-paraganglioma-tumor-association-syndrome-raptas-case-series-and-literature-review
#17
Ruth T Casey, Anne Y Warren, Jose Ezequiel Martin, Benjamin G Challis, Eleanor Rattenberry, James Whitworth, Katrina A Andrews, Thomas Roberts, Graeme R Clark, Hannah West, Philip S Smith, France M Docquier, Fay Rodger, Vicki Murray, Helen L Simpson, Yvonne Wallis, Olivier Giger, Maxine Tran, Susan Tomkins, Grant D Stewart, Soo-Mi Park, Emma R Woodward, Eamonn R Maher
Context: The co-occurrence of pheochromocytoma (PC) and renal tumors was linked to the inherited familial cancer syndrome von Hippel-Lindau (VHL) disease more than six decades ago. Subsequently, other shared genetic causes of predisposition to renal tumors and to PC, paraganglioma (PGL), or head and neck paraganglioma (HNPGL) have been described, but case series of non-VHL-related cases of renal tumor and pheochromocytoma/paraganglioma tumor association syndrome (RAPTAS) are rare. Objective: To determine the clinical and molecular features of non-VHL RAPTAS by literature review and characterization of a case series...
November 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28961572/food-therapy-in-sinosphere-asia
#18
Natural Hoi Sing Chu, Chu Kion Yao, Victoria Ping Yi Tan
Traditional Chinese Food Therapy has long been an integral part of dietary practices in Sinosphere Asia. This therapy is defined by the classification of foods into cooling (Yin) and heaty (Yang) and the manipulation of dietary intake of these foods as a therapeutic strategy for chronic diseases. Both functional dyspepsia (FD) and irritable bowel syndrome (IBS) are chronic, functional gut disorders widely prevalent in Sinosphere Asia. Diet is increasingly recognized as a symptom trigger in FD and IBS, and the evidence suggesting the utility of diet therapies as front-line management is growing, particularly in the West...
September 28, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28944419/brugada-syndrome-revealed-by-intestinal-shigellosis-in-a-patient-from-benin-at-the-university-hospital-of-saint-etienne
#19
Y T Aba, A Fresard, A Gagneux-Brunon, M F Lutz, C Cazorla, F Lucht, E Botelho-Nevers, E Bissagnene, A Da Costa
This paper is about a Brugada syndrome (BS) of accidental discovery in a patient from Benin during an intestinal shigellosis episode in the infectiology department of university hospital of Saint-Etienne, France. Authors establish a link between these two diseases. After a literature's review, they underline that BS is under-diagnosed in Africa. Furthermore, they highlight socio-cultural characteristics of sudden deaths in West Africa including BS.
October 2017: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/28943297/transcriptome-analysis-of-kuruma-shrimp-marsupenaeus-japonicus-hepatopancreas-in-response-to-white-spot-syndrome-virus-wssv-under-experimental-infection
#20
Shengping Zhong, Yong Mao, Jun Wang, Min Liu, Man Zhang, Yongquan Su
Kuruma shrimp (Marsupenaeus japonicus) is one of the most valuable crustacean species in capture fisheries and mariculture in the Indo-West Pacific. White spot syndrome virus (WSSV) is a highly virulent pathogen which has seriously threatened Kuruma shrimp aquaculture sector. However, little information is available in relation to underlying mechanisms of host-virus interaction in Kuruma shrimp. In this study, we performed a transcriptome analysis from the hepatopancreas of Kuruma shrimp challenged by WSSV, using Illumina-based RNA-Seq...
September 21, 2017: Fish & Shellfish Immunology
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