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Metaanalysis brain

Vanessa D Arriola, Jeffrey W Rozelle
Traumatic brain injury (TBI) is commonly defined by Menon et al. as an "alteration of the brain function, or other evidence of brain pathology, caused by an external force." TBI can be caused by penetrating trauma to the head in which the magnitude of the injury is dependent on the magnitude of the forces that are applied to the head. The consequences of TBI can range from minimal to severe disability and even death. The major objectives of this systematic review are to survey the current literature on Operation Enduring Freedom (OEF) and Operation Iraqi Freedom (OIF) Hispanic veterans with TBI...
2016: Behavioral Sciences
Cho-Yi Chen, Ryan W Logan, Tianzhou Ma, David A Lewis, George C Tseng, Etienne Sibille, Colleen A McClung
With aging, significant changes in circadian rhythms occur, including a shift in phase toward a "morning" chronotype and a loss of rhythmicity in circulating hormones. However, the effects of aging on molecular rhythms in the human brain have remained elusive. Here, we used a previously described time-of-death analysis to identify transcripts throughout the genome that have a significant circadian rhythm in expression in the human prefrontal cortex [Brodmann's area 11 (BA11) and BA47]. Expression levels were determined by microarray analysis in 146 individuals...
January 5, 2016: Proceedings of the National Academy of Sciences of the United States of America
Barbara Bennani-Baiti, Stefan Toegel, Helmut Viernstein, Ernst Urban, Christian R Noe, Idriss M Bennani-Baiti
Endothelial cells are often present at inflammation sites. This is the case of endothelial cells of the blood-brain barrier (BBB) of patients afflicted with neurodegenerative disorders such as Alzheimer's, Parkinson's, or multiple sclerosis, as well as in cases of bacterial meningitis, trauma, or tumor-associated ischemia. Inflammation is a known modulator of gene expression through the activation of transcription factors, mostly NF-κB. RLIP76 (a.k.a. RALBP1), an ATP-dependent transporter of electrophile-glutathione conjugates, modulates BBB permeability through the regulation of tight junction function, cell adhesion, and exocytosis...
2015: PloS One
Farbod Sedaghat-Hamedani, Elham Kayvanpour, Lutz Frankenstein, Derliz Mereles, Ali Amr, Sebastian Buss, Andreas Keller, Evangelos Giannitsis, Katrin Jensen, Hugo A Katus, Benjamin Meder
BACKGROUND: Biomarkers are well established for diagnosis of myocardial infarction [cardiac troponins, high-sensitivity cardiac troponins (hs-cTn)], exclusion of acute and chronic heart failure [B-type natriuretic peptide (BNP), N-terminal proBNP (NT-proBNP)] and venous thromboembolism (d-dimers). Several studies have demonstrated acute increases in cardiac biomarkers and altered cardiac function after strenuous sports that can pretend a cardiovascular emergency and interfere with state-of-the-art clinical assessment...
October 2015: Clinical Chemistry
T L Richards, T J Grabowski, P Boord, K Yagle, M Askren, Z Mestre, P Robinson, O Welker, D Gulliford, W Nagy, V Berninger
Based on comprehensive testing and educational history, children in grades 4-9 (on average 12 years) were diagnosed with dysgraphia (persisting handwriting impairment) or dyslexia (persisting word spelling/reading impairment) or as typical writers and readers (controls). The dysgraphia group (n = 14) and dyslexia group (n = 17) were each compared to the control group (n = 9) and to each other in separate analyses. Four brain region seed points (left occipital temporal gyrus, supramarginal gyrus, precuneus, and inferior frontal gyrus) were used in these analyses which were shown in a metaanalysis to be related to written word production on four indicators of white matter integrity and fMRI functional connectivity for four tasks (self-guided mind wandering during resting state, writing letter that follows a visually displayed letter in alphabet, writing missing letter to create a correctly spelled real word, and planning for composing after scanning on topic specified by researcher)...
2015: NeuroImage: Clinical
James J DiNicolantonio, Tian Hu, Carl J Lavie, James H O'Keefe, Sripal Bangalore
BACKGROUND: Angiotensin-converting enzyme (ACE) inhibitors are highly effective at improving prognosis in a variety of disease states such as hypertension, cardiovascular disease, systolic heart failure, and acute coronary syndrome. Although these medications have been used in clinical practice for decades, not all ACE inhibitors are equal, as agents within this class vary in lipophilicity, tissue-ACE binding, antioxidant properties, antiinflammatory properties, bradykinin site selectivity, and duration of action...
2014: Ochsner Journal
Laura C Erickson, Elizabeth Heeg, Josef P Rauschecker, Peter E Turkeltaub
The brain improves speech processing through the integration of audiovisual (AV) signals. Situations involving AV speech integration may be crudely dichotomized into those where auditory and visual inputs contain (1) equivalent, complementary signals (validating AV speech) or (2) inconsistent, different signals (conflicting AV speech). This simple framework may allow the systematic examination of broad commonalities and differences between AV neural processes engaged by various experimental paradigms frequently used to study AV speech integration...
November 2014: Human Brain Mapping
David Stacey, Ainhoa Bilbao, Matthieu Maroteaux, Tianye Jia, Alanna C Easton, Sophie Longueville, Charlotte Nymberg, Tobias Banaschewski, Gareth J Barker, Christian Büchel, Fabiana Carvalho, Patricia J Conrod, Sylvane Desrivières, Mira Fauth-Bühler, Alberto Fernandez-Medarde, Herta Flor, Jürgen Gallinat, Hugh Garavan, Arun L W Bokde, Andreas Heinz, Bernd Ittermann, Mark Lathrop, Claire Lawrence, Eva Loth, Anbarasu Lourdusamy, Karl F Mann, Jean-Luc Martinot, Frauke Nees, Miklós Palkovits, Tomas Paus, Zdenka Pausova, Marcella Rietschel, Barbara Ruggeri, Eugenio Santos, Michael N Smolka, Oliver Staehlin, Marjo-Riitta Jarvelin, Paul Elliott, Wolfgang H Sommer, Manuel Mameli, Christian P Müller, Rainer Spanagel, Jean-Antoine Girault, Gunter Schumann
The firing of mesolimbic dopamine neurons is important for drug-induced reinforcement, although underlying genetic factors remain poorly understood. In a recent genome-wide association metaanalysis of alcohol intake, we identified a suggestive association of SNP rs26907 in the ras-specific guanine-nucleotide releasing factor 2 (RASGRF2) gene, encoding a protein that mediates Ca(2+)-dependent activation of the ERK pathway. We performed functional characterization of this gene in relation to alcohol-related phenotypes and mesolimbic dopamine function in both mice and adolescent humans...
December 18, 2012: Proceedings of the National Academy of Sciences of the United States of America
Jae-Jin Song, Dirk De Ridder, Paul Van de Heyning, Sven Vanneste
UNLABELLED: In tinnitus, PET and other functional imaging modalities have shown functional changes not only in the auditory cortex but also in nonauditory regions such as the limbic, frontal, and parietal areas. Nonetheless, disparities in task dimension among studies, low statistical power due to small sample size, and the intrinsic uncertainty of a modality that measures activity indirectly limit the comprehensive understanding of the results from PET studies. These difficulties prompted us to undertake a metaanalysis of PET studies on tinnitus using a coordinate-based technique (activation-likelihood estimation) to retrieve the most consistent activation areas across different task dimensions and to compare the results with those from other imaging modalities...
October 2012: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Trygve E Bakken, J Cooper Roddey, Srdjan Djurovic, Natacha Akshoomoff, David G Amaral, Cinnamon S Bloss, B J Casey, Linda Chang, Thomas M Ernst, Jeffrey R Gruen, Terry L Jernigan, Walter E Kaufmann, Tal Kenet, David N Kennedy, Joshua M Kuperman, Sarah S Murray, Elizabeth R Sowell, Lars M Rimol, Morten Mattingsdal, Ingrid Melle, Ingrid Agartz, Ole A Andreassen, Nicholas J Schork, Anders M Dale, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R Jack, William Jagust, John Q Trojanowki, Arthur W Toga, Laurel Beckett, Robert C Green, Andrew J Saykin, John Morris, Enchi Liu, Tom Montine, Anthony Gamst, Ronald G Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Danielle Harvey, John Kornak, Anders Dale, Matthew Bernstein, Joel Felmlee, Nick Fox, Paul Thompson, Norbert Schuff, Gene Alexander, Charles DeCarli, Dan Bandy, Robert A Koeppe, Norm Foster, Eric M Reiman, Kewei Chen, Chet Mathis, Nigel J Cairns, Lisa Taylor-Reinwald, J Q Trojanowki, Les Shaw, Virginia M Y Lee, Magdalena Korecka, Karen Crawford, Scott Neu, Tatiana M Foroud, Steven Potkin, Li Shen, Zaven Kachaturian, Richard Frank, Peter J Snyder, Susan Molchan, Jeffrey Kaye, Joseph Quinn, Betty Lind, Sara Dolen, Lon S Schneider, Sonia Pawluczyk, Bryan M Spann, James Brewer, Helen Vanderswag, Judith L Heidebrink, Joanne L Lord, Kris Johnson, Rachelle S Doody, Javier Villanueva-Meyer, Munir Chowdhury, Yaakov Stern, Lawrence S Honig, Karen L Bell, John C Morris, Beau Ances, Maria Carroll, Sue Leon, Mark A Mintun, Stacy Schneider, Daniel Marson, Randall Griffith, David Clark, Hillel Grossman, Effie Mitsis, Aliza Romirowsky, Leyla deToledo-Morrell, Raj C Shah, Ranjan Duara, Daniel Varon, Peggy Roberts, Marilyn Albert, Chiadi Onyike, Stephanie Kielb, Henry Rusinek, Mony J de Leon, Lidia Glodzik, Susan De Santi, P Murali Doraiswamy, Jeffrey R Petrella, R Edward Coleman, Steven E Arnold, Jason H Karlawish, David Wolk, Charles D Smith, Greg Jicha, Peter Hardy, Oscar L Lopez, MaryAnn Oakley, Donna M Simpson, Anton P Porsteinsson, Bonnie S Goldstein, Kim Martin, Kelly M Makino, M Saleem Ismail, Connie Brand, Ruth A Mulnard, Gaby Thai, Catherine Mc-Adams-Ortiz, Kyle Womack, Dana Mathews, Mary Quiceno, Ramon Diaz-Arrastia, Richard King, Myron Weiner, Kristen Martin-Cook, Michael DeVous, Allan I Levey, James J Lah, Janet S Cellar, Jeffrey M Burns, Heather S Anderson, Russell H Swerdlow, Liana Apostolova, Po H Lu, George Bartzokis, Daniel H S Silverman, Neill R Graff-Radford, Francine Parfitt, Heather Johnson, Martin R Farlow, Ann Marie Hake, Brandy R Matthews, Scott Herring, Christopher H van Dyck, Richard E Carson, Martha G MacAvoy, Howard Chertkow, Howard Bergman, Chris Hosein, Sandra Black, Bojana Stefanovic, Curtis Caldwell, Ging-Yuek, Robin Hsiung, Howard Feldman, Benita Mudge, Michele Assaly, Andrew Kertesz, John Rogers, Dick Trost, Charles Bernick, Donna Munic, Diana Kerwin, Marek-Marsel Mesulam, Kristina Lipowski, Chuang-Kuo Wu, Nancy Johnson, Carl Sadowsky, Walter Martinez, Teresa Villena, Raymond Scott Turner, Kathleen Johnson, Brigid Reynolds, Reisa A Sperling, Keith A Johnson, Gad Marshall, Meghan Frey, Jerome Yesavage, Joy L Taylor, Barton Lane, Allyson Rosen, Jared Tinklenberg, Marwan Sabbagh, Christine Belden, Sandra Jacobson, Neil Kowall, Ronald Killiany, Andrew E Budson, Alexander Norbash, Patricia Lynn Johnson, Thomas O Obisesan, Saba Wolday, Salome K Bwayo, Alan Lerner, Leon Hudson, Paula Ogrocki, Evan Fletcher, Owen Carmichael, John Olichney, Smita Kittur, Michael Borrie, T-Y Lee, Rob Bartha, Sterling Johnson, Sanjay Asthana, Cynthia M Carlsson, Steven G Potkin, Adrian Preda, Dana Nguyen, Pierre Tariot, Adam Fleisher, Stephanie Reeder, Vernice Bates, Horacio Capote, Michelle Rainka, Douglas W Scharre, Maria Kataki, Earl A Zimmerman, Dzintra Celmins, Alice D Brown, Godfrey D Pearlson, Karen Blank, Karen Anderson, Robert B Santulli, Eben S Schwartz, Kaycee M Sink, Jeff D Williamson, Pradeep Garg, Franklin Watkins, Brian R Ott, Henry Querfurth, Geoffrey Tremont, Stephen Salloway, Paul Malloy, Stephen Correia, Howard J Rosen, Bruce L Miller, Jacobo Mintzer, Crystal Flynn Longmire, Kenneth Spicer, Elizabether Finger, Irina Rachinsky, Dick Drost, Terry Jernigan, Connor McCabe, Ellen Grant, Thomas Ernst, Josh Kuperman, Yoon Chung, Sarah Murray, Cinnamon Bloss, Burcu Darst, Lexi Pritchett, Ashley Saito, David Amaral, Mishaela DiNino, Bella Eyngorina, Elizabeth Sowell, Suzanne Houston, Lindsay Soderberg, Walter Kaufmann, Peter van Zijl, Hilda Rizzo-Busack, Mohsin Javid, Natasha Mehta, Erika Ruberry, Alisa Powers, Bruce Rosen, Nitzah Gebhard, Holly Manigan, Jean Frazier, David Kennedy, Lauren Yakutis, Michael Hill, Jeffrey Gruen, Joan Bosson-Heenan, Heatherly Carlson
Visual cortical surface area varies two- to threefold between human individuals, is highly heritable, and has been correlated with visual acuity and visual perception. However, it is still largely unknown what specific genetic and environmental factors contribute to normal variation in the area of visual cortex. To identify SNPs associated with the proportional surface area of visual cortex, we performed a genome-wide association study followed by replication in two independent cohorts. We identified one SNP (rs6116869) that replicated in both cohorts and had genome-wide significant association (P(combined) = 3...
March 6, 2012: Proceedings of the National Academy of Sciences of the United States of America
Vincent Dunet, Christine Rossier, Alfred Buck, Roger Stupp, John O Prior
UNLABELLED: For the past decade, PET with (18)F-fluoro-ethyl-tyrosine ((18)F-FET) has been used in the evaluation of patients with primary brain tumors (PBTs), but so far series have reported only a limited number of patients. The purpose of this systematic review and metaanalysis was to assess the diagnostic performance of (18)F-FET PET in patients with suspicion of PBT. METHODS: We examined studies published in the literature using MEDLINE and EMBASE databases...
February 2012: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Nicolaas I Bohnen, David S W Djang, Karl Herholz, Yoshimi Anzai, Satoshi Minoshima
Imaging that can detect pathophysiologic change in the brain holds great promise for diagnostic assessment of patients with Alzheimer disease (AD) and dementia. Although a previous metaanalysis centering on literature from 1990 to 2000 showed a summary accuracy of 86% for (18)F-FDG PET for AD diagnosis, the clinical value was considered uncertain because of methodologic shortcomings. Review of the recent literature since 2000 demonstrates that the evidence for (18)F-FDG PET in assessment of dementia has increased with new studies that include autopsy confirmation, wide-diagnostic-spectrum recruitment in primary care settings, historical and prospective cohort studies, and multicenter data analyses...
January 2012: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
G V Nedugov
The author has undertaken the systematic search for the description of isolated and serial cases of spontaneous redistribution of acute intracranial subdural hematomas with their mandatory computed and magneto-resonance neurovisualization. Based on the results of the search and metaanalysis of statistical data, it is concluded that acute intracranial subdural are likely to undergo any possible dislocation over the surface of the large hemispheres of the brain as well as downward transtentorial and spinal migration...
September 2011: Sudebno-meditsinskaia Ekspertiza
Samuel J Maiser, Alexandros L Georgiadis, M Fareed K Suri, Gabriela Vazquez, Kamakshi Lakshminarayan, Adnan I Qureshi
OBJECTIVE: To assess the efficacy of intravenous recombinant tissue plasminogen activator administered after 3 h following onset of ischaemic stroke. BACKGROUND: Some recent data indicate that treatment with intravenous recombinant tissue plasminogen activator may be beneficial even when administered to ischaemic stroke patients beyond 3 h from symptom onset. METHODS: We searched the medical literature using the MEDLINE, BIOSIS, and Cochrane databases for pertinent publications from 1966 to 2008 using the keywords 'alteplase', 'tissue plasminogen activator', and 'stroke'...
February 2011: International Journal of Stroke: Official Journal of the International Stroke Society
Per-Olof Grände, Karen-Lise Welling, Vagn Eskesen, Bertil Romner
A Cochrane metaanalysis and a study performed on children have recently confirmed that therapeutic hypothermia does not improve outcome after severe traumatic brain injury (TBI). TBI is not comparable to a short episode of global ischemia, where therapeutic hypothermia has been shown to improve outcome. The difference may be explained by the fact that hypothermia-induced stress after a traumatic brain injury reduces cerebral perfusion in the penumbra zone, where local circulation is already reduced. Thus, to date there is no indication for therapeutic hypothermia in TBI patients...
May 10, 2010: Ugeskrift for Laeger
Kaori Miyamoto, Motoko Shiozaki, Masahiro Shibata, Masato Koike, Yasuo Uchiyama, Takahiro Gotow
Tocopherols and tocotrienols constitute the vitamin E family. Although alpha-tocotrienol is the most neuroprotective form of vitamin E proved to be effective against stroke, alpha-tocopherol is the most abundant in nature and is used most often for disease prevention/treatment. A recent metaanalysis of human studies suggested that alpha-tocopherol supplementation increases all-cause mortality. Therefore, we investigated the effects of alpha-tocopherol ( approximately 44 mg/kg body weight; equivalent to 2,600 mg/human/day) on the central nervous system (CNS) of stroke-prone spontaneously hypertensive rats (SHRSP)...
February 2009: Journal of Neuroscience Research
Erwin Stolz, Francesca Cioli, Jens Allendoerfer, Tibo Gerriets, Massimo Del Sette, Manfred Kaps
BACKGROUND AND PURPOSE: Prediction of short- and long-term prognosis is an important issue in acute stroke care. This metaanalysis explores the prognostic value of initial bed-side transcranial ultrasound in acute stroke. METHODS: All studies prospectively applying TCCS or TCD within 24 hours of symptom onset in acute stroke, with a minimal cohort size of 20 patients, and reporting clinical outcome variables in relation to the vascular findings were included into this metaanalysis...
December 2008: Stroke; a Journal of Cerebral Circulation
Marco D Sorani, Geoffrey T Manley
OBJECTIVE: Brain edema can increase intracranial pressure (ICP), potentially leading to ischemia, herniation, and death. Edema and elevated ICP are often treated with osmotic agents to remove water from brain tissue. Mannitol is the osmotic diuretic most commonly used in the intensive care unit; however, despite its clinical importance, treatment protocols vary from center to center, and the dose-response relationship is not understood. The goal of this metaanalysis was to aggregate and analyze data from studies in which authors have described the dose-response relationship between mannitol and ICP...
January 2008: Journal of Neurosurgery
Andrew F Shorr, William L Jackson, John H Sherner, Lisa K Moores
BACKGROUND: Venous thromboembolism (VTE) remains a major cause of morbidity following stroke. The optimal form of pharmacologic prophylaxis following stroke is unknown. METHODS: We identified randomized trials comparing unfractionated heparin (UFH) to low-molecular-weight heparin (LMWH) for VTE prevention in ischemic stroke patients. We focused on the risk for VTE, pulmonary embolism (PE), bleeding, and mortality as a function of the type of agent used for prophylaxis...
January 2008: Chest
David J Samson, Jerome Seidenfeld, George R Simon, Andrew T Turrisi, Claudia Bonnell, Kathleen M Ziegler, Naomi Aronson et al.
PURPOSES: This systematic review addressed the following key questions on managing small cell lung cancer (SCLC): the sequence, timing, and dosing characteristics of primary thoracic radiotherapy (TRTx) for limited-stage disease; primary TRTx for extensive-stage disease; effect of prophylactic cranial irradiation (PCI); positron emission tomography (PET) for staging; treatment of mixed histology tumors; surgery; and second-line and subsequent-line treatment for relapsed/progressive disease...
September 2007: Chest
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