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https://www.readbyqxmd.com/read/28421932/learning-disability-nurse-numbers-heading-in-the-wrong-direction
#1
(no author information available yet)
The UK's record on supporting people with learning disabilities is patchy to say the least. For decades people were housed in inappropriate institutions where abuse was rife, and attempts to improve their lives by delivering better services in the community have come up short because they have not been afforded sufficient priority.
April 19, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28419609/band-aids-for-buchnera-and-b-vitamins-for-all
#2
Jacob A Russell, Kerry M Oliver, Allison K Hansen
Evolution lacks foresight, and hence, key adaptations may produce major challenges over the long run. The natural world is rife with examples of long-term 'side effects' associated with quick-fix tinkering, including blind spots in vertebrate eyes. An important question is how nature compensates for imperfections once evolution has set a course. The symbioses associated with sap-feeding insects present a fascinating opportunity to address this issue. On one hand, the substantial diversity and biomass of sap-feeding insects are largely due to ancient acquisitions of nutrient-provisioning bacterial symbionts...
April 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28400787/silicification-in-grasses-variation-between-different-cell-types
#3
REVIEW
Santosh Kumar, Milan Soukup, Rivka Elbaum
Plants take up silicon as mono-silicic acid, which is released to soil by the weathering of silicate minerals. Silicic acid can be taken up by plant roots passively or actively, and later it is deposited in its polymerized form as amorphous hydrated silica. Major silica depositions in grasses occur in root endodermis, leaf epidermal cells, and outer epidermal cells of inflorescence bracts. Debates are rife about the mechanism of silica deposition, and two contrasting scenarios are often proposed to explain it...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28366126/prescriptions-filled-following-an-opioid-related-hospitalization
#4
Ellen Herbst, Tauheed Zaman, Tessa Rife
No abstract text is available yet for this article.
April 1, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28355975/the-potential-of-collective-intelligence-in-emergency-medicine
#5
Juliane E Kämmer, Wolf E Hautz, Stefan M Herzog, Olga Kunina-Habenicht, Ralf H J M Kurvers
BACKGROUND: Evidence suggests that pooling multiple independent diagnoses can improve diagnostic accuracy in well-defined tasks. We investigated whether this is also the case for diagnostics in emergency medicine, an ill-defined task environment where diagnostic errors are rife. METHODS: A computer simulation study was conducted based on empirical data from 2 published experimental studies. In the computer experiments, 285 medical students independently diagnosed 6 simulated patients arriving at the emergency room with dyspnea...
March 1, 2017: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/28337689/managing-chronic-pain-in-primary-care-it-really-does-take-a-village
#6
Karen Seal, William Becker, Jennifer Tighe, Yongmei Li, Tessa Rife
Some healthcare systems are relieving primary care providers (PCPs) of "the burden" of managing chronic pain and opioid prescribing, instead offloading chronic pain management to pain specialists. Last year the Centers for Disease Control and Prevention recommended a biopsychosocial approach to pain management that discourages opioid use and promotes exercise therapy, cognitive behavioral therapy and non-opioid medications as first-line patient-centered, multi-modal treatments best delivered by an interdisciplinary team...
March 23, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28336175/the-academic-industrial-complex-navigating-the-translational-and-cultural-divide
#7
REVIEW
Stephen Freedman, Kevin Mullane
In general, the fruits of academic discoveries can only be realized through joint efforts with industry. However, the poor reproducibility of much academic research has damaged credibility and jeopardized translational efforts that could benefit patients. Meanwhile, journals are rife with articles bemoaning the limited productivity and increasing costs of the biopharmaceutical industry and its resultant predilection for mergers and reorganizations while decreasing internal research efforts. The ensuing disarray and uncertainty has created tremendous opportunities for academia and industry to form even closer ties, and to embrace new operational and financial models to their joint benefit...
March 20, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28242753/sequencing-errors-rife-in-genome-databases
#8
(no author information available yet)
Low-frequency genetic variants in cancer genome datasets are often simply artifacts of DNA damage introduced by routine sample preparation, not tumor-driving mutations. A new algorithm found that around three quarters of all the samples in The Cancer Genome Atlas contain large numbers of these sequencing errors.
February 27, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28235883/ethical-questions-identified-in-a-study-of-local-and-expatriate-responders-perspectives-of-vulnerability-in-the-2010-haiti-earthquake
#9
Evelyne Durocher, Ryoa Chung, Christiane Rochon, Jean-Hugues Henrys, Catherine Olivier, Matthew Hunt
BACKGROUND: Situations of disaster that prompt international humanitarian responses are rife with ethical tensions. The 2010 Haiti earthquake caused great destruction and prompted a massive humanitarian response. The widespread needs experienced by the population and the scale of the response inevitably rendered priority-setting difficult, and gave rise to ethical challenges. PURPOSE: This paper presents four ethical questions identified in the analysis of a study on vulnerability and equity in the humanitarian response to the 2010 Haiti earthquake...
February 24, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/28211601/biogeography-of-nodulated-legumes-and-their-nitrogen-fixing-symbionts
#10
REVIEW
Janet I Sprent, Julie Ardley, Euan K James
Contents I. II. III. IV. V. VI. VII. VIII. References SUMMARY: In the last decade, analyses of both molecular and morphological characters, including nodulation, have led to major changes in our understanding of legume taxonomy. In parallel there has been an explosion in the number of genera and species of rhizobia known to nodulate legumes. No attempt has been made to link these two sets of data or to consider them in a biogeographical context. This review aims to do this by relating the data to the evolution of the two partners: it highlights both longitudinal and latitudinal trends and considers these in relation to the location of major land masses over geological time...
February 17, 2017: New Phytologist
https://www.readbyqxmd.com/read/28125645/gbs-based-deconvolution-of-the-surviving-north-american-collection-of-cold-hardy-kiwifruit-actinidia-spp-germplasm
#11
Arthur T O Melo, Robert S Guthrie, Iago Hale
Plant germplasm collections can be invaluable resources to plant breeders, provided they are well-characterized. After 140 years of acquisition and curation efforts by a wide and largely non-coordinated array of private and institutional actors, the current US collection of cold-hardy kiwifruit (Actinidia spp.) is rife with misclassifications, misnomers, and mix-ups. To facilitate the systematic improvement and resource-efficient curation of these species of long-recognized horticultural potential, we used genotyping-by-sequencing (GBS) data to deconvolute this historic collection...
2017: PloS One
https://www.readbyqxmd.com/read/28094017/predictive-markers-guide-differentiation-to-improve-graft-outcome-in-clinical-translation-of-hesc-based-therapy-for-parkinson-s-disease
#12
Agnete Kirkeby, Sara Nolbrant, Katarina Tiklova, Andreas Heuer, Nigel Kee, Tiago Cardoso, Daniella Rylander Ottosson, Mariah J Lelos, Pedro Rifes, Stephen B Dunnett, Shane Grealish, Thomas Perlmann, Malin Parmar
Stem cell treatments for neurodegenerative diseases are expected to reach clinical trials soon. Most of the approaches currently under development involve transplantation of immature progenitors that subsequently undergo phenotypic and functional maturation in vivo, and predicting the long-term graft outcome already at the progenitor stage remains a challenge. Here, we took an unbiased approach to identify predictive markers expressed in dopamine neuron progenitors that correlate with graft outcome in an animal model of Parkinson's disease through gene expression analysis of >30 batches of grafted human embryonic stem cell (hESC)-derived progenitors...
January 5, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28080206/gut-microbes-manuscript-type-commentary-and-views-submission-probiotics-d-lactic-acidosis-oxidative-stress-and-strain-specificity
#13
Luis Vitetta, Samantha Coulson, Michael Thomsen, Tony Nguyen, Sean Hall
The existence of an implicit living microscopic world, composed primarily of bacteria, has been known for centuries. The exact mechanisms that govern the contribution of bacteria to human health and disease have only recently become the subject of intense research efforts. Within this very evident shift in paradigms, the rational design of probiotic formulations has led to the creation of an industry that seeks to progress the engineering of probiotic bacteria that produce metabolites that may enhance human host health and prevent disease...
January 12, 2017: Gut Microbes
https://www.readbyqxmd.com/read/27958238/telemedicine-and-biomedical-care-in-africa-prospects-and-challenges
#14
REVIEW
I J Okoroafor, F N Chukwuneke, N Ifebunandu, T C Onyeka, C O Ekwueme, K K Agwuna
The use of information and communication technology for health care delivery, particularly in poor settings where access to medical services is inadequate, holds promise in expanding health care access. In rural or impoverished environment, where disease is prevalent, doctors are scarce, and health care infrastructure is inadequate, telemedicine holds a good prospect in improving the health conditions of the people. However, telemedical practice in Africa cannot be without challenges because some aspects are often difficult to implement in underdeveloped settings where ignorance and poverty are rife...
January 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/27919399/a-literature-review-for-large-scale-health-information-system-project-planning-implementation-and-evaluation
#15
REVIEW
Judith Sligo, Robin Gauld, Vaughan Roberts, Luis Villa
Information technology is perceived as a potential panacea for healthcare organisations to manage pressure to improve services in the face of increased demand. However, the implementation and evaluation of health information systems (HIS) is plagued with problems and implementation shortcomings and failures are rife. HIS implementation is complex and relies on organisational, structural, technological, and human factors to be successful. It also requires reflective, nuanced, multidimensional evaluation to provide ongoing feedback to ensure success...
January 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/27903869/within-group-behavioural-consequences-of-between-group-conflict-a-prospective-review
#16
REVIEW
Andrew N Radford, Bonaventura Majolo, Filippo Aureli
Conflict is rife in group-living species and exerts a powerful selective force. Group members face a variety of threats from extra-group conspecifics, from individuals looking for reproductive opportunities to rival groups seeking resources. Theory predicts that such between-group conflict should influence within-group behaviour. However, compared with the extensive literature on the consequences of within-group conflict, relatively little research has considered the behavioural impacts of between-group conflict...
November 30, 2016: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/27897750/i-know-how-tb-patients-feel
#17
Mel Burden
During 2010-11 I spent 6 months working in a rural South African hospital, where drug-resistant tuberculosis (TB) was rife. I was diagnosed with TB 10 months after my return to the UK.
November 16, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27856180/sometimes-scientists-get-the-flu-wrong%C3%A2
#18
Matteo Marcantonio, Emily L Pascoe, Frédéric Baldacchino
In an international research environment, accurate communication is vital. However, the scientific literature does not always utilise consistent terminology and the misuse of some expressions in epidemiology is rife. We encourage the correct terms to be used appropriately to avoid confusion between scientists, policy makers, and members of the public.
January 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/27816921/is-rif-rife
#19
EDITORIAL
J L H Hans Evers
No abstract text is available yet for this article.
November 5, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27769243/the-potential-for-non-adaptive-origins-of-evolutionary-innovations-in-central-carbon-metabolism
#20
Sayed-Rzgar Hosseini, Andreas Wagner
BACKGROUND: Biological systems are rife with examples of pre-adaptations or exaptations. They range from the molecular scale - lens crystallins, which originated from metabolic enzymes - to the macroscopic scale, such as feathers used in flying, which originally served thermal insulation or waterproofing. An important class of exaptations are novel and useful traits with non-adaptive origins. Whether such origins could be frequent cannot be answered with individual examples, because it is a question about a biological system's potential for exaptation...
October 21, 2016: BMC Systems Biology
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