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https://www.readbyqxmd.com/read/28094017/predictive-markers-guide-differentiation-to-improve-graft-outcome-in-clinical-translation-of-hesc-based-therapy-for-parkinson-s-disease
#1
Agnete Kirkeby, Sara Nolbrant, Katarina Tiklova, Andreas Heuer, Nigel Kee, Tiago Cardoso, Daniella Rylander Ottosson, Mariah J Lelos, Pedro Rifes, Stephen B Dunnett, Shane Grealish, Thomas Perlmann, Malin Parmar
Stem cell treatments for neurodegenerative diseases are expected to reach clinical trials soon. Most of the approaches currently under development involve transplantation of immature progenitors that subsequently undergo phenotypic and functional maturation in vivo, and predicting the long-term graft outcome already at the progenitor stage remains a challenge. Here, we took an unbiased approach to identify predictive markers expressed in dopamine neuron progenitors that correlate with graft outcome in an animal model of Parkinson's disease through gene expression analysis of >30 batches of grafted human embryonic stem cell (hESC)-derived progenitors...
January 5, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28080206/probiotics-d-lactic-acidosis-oxidative-stress-and-strain-specificity
#2
Luis Vitetta, Samantha Coulson, Michael Thomsen, Tony Nguyen, Sean Hall
1. The existence of an implicit living microscopic world, composed primarily of bacteria, has been known for centuries. The exact mechanisms that govern the contribution of bacteria to human health and disease have only recently become the subject of intense research efforts. Within this very evident shift in paradigms, the rational design of probiotic formulations has led to the creation of an industry that seeks to progress the engineering of probiotic bacteria that produce metabolites that may enhance human host health and prevent disease...
January 12, 2017: Gut Microbes
https://www.readbyqxmd.com/read/27958238/telemedicine-and-biomedical-care-in-africa-prospects-and-challenges
#3
REVIEW
I J Okoroafor, F N Chukwuneke, N Ifebunandu, T C Onyeka, C O Ekwueme, K K Agwuna
The use of information and communication technology for health care delivery, particularly in poor settings where access to medical services is inadequate, holds promise in expanding health care access. In rural or impoverished environment, where disease is prevalent, doctors are scarce, and health care infrastructure is inadequate, telemedicine holds a good prospect in improving the health conditions of the people. However, telemedical practice in Africa cannot be without challenges because some aspects are often difficult to implement in underdeveloped settings where ignorance and poverty are rife...
January 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/27919399/a-literature-review-for-large-scale-health-information-system-project-planning-implementation-and-evaluation
#4
REVIEW
Judith Sligo, Robin Gauld, Vaughan Roberts, Luis Villa
Information technology is perceived as a potential panacea for healthcare organisations to manage pressure to improve services in the face of increased demand. However, the implementation and evaluation of health information systems (HIS) is plagued with problems and implementation shortcomings and failures are rife. HIS implementation is complex and relies on organisational, structural, technological, and human factors to be successful. It also requires reflective, nuanced, multidimensional evaluation to provide ongoing feedback to ensure success...
January 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/27903869/within-group-behavioural-consequences-of-between-group-conflict-a-prospective-review
#5
REVIEW
Andrew N Radford, Bonaventura Majolo, Filippo Aureli
Conflict is rife in group-living species and exerts a powerful selective force. Group members face a variety of threats from extra-group conspecifics, from individuals looking for reproductive opportunities to rival groups seeking resources. Theory predicts that such between-group conflict should influence within-group behaviour. However, compared with the extensive literature on the consequences of within-group conflict, relatively little research has considered the behavioural impacts of between-group conflict...
November 30, 2016: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/27897750/i-know-how-tb-patients-feel
#6
Mel Burden
During 2010-11 I spent 6 months working in a rural South African hospital, where drug-resistant tuberculosis (TB) was rife. I was diagnosed with TB 10 months after my return to the UK.
November 16, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27856180/sometimes-scientists-get-the-flu-wrong%C3%A2
#7
Matteo Marcantonio, Emily L Pascoe, Frédéric Baldacchino
In an international research environment, accurate communication is vital. However, the scientific literature does not always utilise consistent terminology and the misuse of some expressions in epidemiology is rife. We encourage the correct terms to be used appropriately to avoid confusion between scientists, policy makers, and members of the public.
January 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/27816921/is-rif-rife
#8
EDITORIAL
J L H Hans Evers
No abstract text is available yet for this article.
November 5, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27769243/the-potential-for-non-adaptive-origins-of-evolutionary-innovations-in-central-carbon-metabolism
#9
Sayed-Rzgar Hosseini, Andreas Wagner
BACKGROUND: Biological systems are rife with examples of pre-adaptations or exaptations. They range from the molecular scale - lens crystallins, which originated from metabolic enzymes - to the macroscopic scale, such as feathers used in flying, which originally served thermal insulation or waterproofing. An important class of exaptations are novel and useful traits with non-adaptive origins. Whether such origins could be frequent cannot be answered with individual examples, because it is a question about a biological system's potential for exaptation...
October 21, 2016: BMC Systems Biology
https://www.readbyqxmd.com/read/27733348/corruption-in-healthcare-is-rife-worldwide-finds-report
#10
Deborah Cohen, Michael Petkov
No abstract text is available yet for this article.
October 12, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27682352/primary-aldosteronism-in-the-primary-care-clinic-rife-or-rare
#11
James Brian Byrd
ARR = aldosterone-to-renin ratio MR = mineralocorticoid receptor PA = primary aldosteronism.
November 2016: Endocrine Practice
https://www.readbyqxmd.com/read/27673737/the-reinforcement-of-ableism-normality-the-medical-model-of-disability-and-humanism-in-applied-behavior-analysis-and-asd
#12
Eric Shyman
The field of educating individuals with Autism Spectrum Disorder has ever been rife with controversy regarding issues ranging from etiology and causation to effective intervention and education options. One such basis for controversy has been between humanism, and humanistic philosophical concepts, and its fundamental differences with behaviorism, and behavioristic philosophical concepts. These differences have long been debated, and the belief that the two orientations are generally mutually exclusive has been largely maintained...
October 2016: Intellectual and Developmental Disabilities
https://www.readbyqxmd.com/read/27620914/correction-for-rife-et-al-evolution-of-neuroadaptation-in-the-periphery-and-purifying-selection-in-the-brain-contribute-to-compartmentalization-of-simian-immunodeficiency-virus-siv-in-the-brains-of-rhesus-macaques-with-siv-associated-encephalitis
#13
Brittany D Rife, David J Nolan, Susanna L Lamers, Patrick Autissier, Tricia Burdo, Kenneth C Williams, Marco Salemi
No abstract text is available yet for this article.
October 1, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27612168/characteristics-of-bicycle-crashes-in-an-adolescent-population-in-flanders-belgium
#14
Jef Vanparijs, Luc Int Panis, Romain Meeusen, Bas de Geus
INTRODUCTION: In regions where transportation is mainly motorized, air pollution and traffic congestion are rife. Active transportation such as cycling might be a solution but safety is a major concern. An efficient science based safety policy is needed. The aim of this paper is to analyze in depth the bicycle crash causes and characteristics in an adolescent population (14-18 yr). METHODS: By using questionnaires for self-reported bicycle crashes, bicycle crash data were collected from insurance companies (January 2014-June 2015) and from schools (November 2013-March 2014)...
December 2016: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/27562449/interventions-to-prevent-child-marriage-among-young-people-in-low-and-middle-income-countries-a-systematic-review-of-the-published-and-gray-literature
#15
REVIEW
Amanda M Kalamar, Susan Lee-Rife, Michelle J Hindin
Child marriage, defined as marriage before the age of 18 years, is a human rights violation that can have lasting adverse educational and economic impacts. The objective of this review was to identify high-quality interventions and evaluations to decease child marriage in low- and middle-income countries. PubMed, Embase, PsycInfo, CINAHL Plus, Popline, and the Cochrane Databases were searched without language limitations for articles published through November 2015. Gray literature was searched by hand. Reference tracing was used, as well as the unpacking of systematic reviews...
September 2016: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/27543146/preliminary-report-on-osteochondrosis-in-cattle-in-the-north-western-parts-of-south-africa
#16
Leon Prozesky, Johan Neser, Heinz Meissner, Kenneth Botha, Lubbe Jacobs, Craig Shepstone, Hannes Viljoen, Hinner Köster, Chris De Brouwer, Jan Van Zyl, Gerjan Van der Veen
The north-western part of South Africa, in particular, is well known for mineral imbalances. Aphosphorosis, resulting in rickets and osteomalacia, received a lot of attention at the turn of the nineteenth century (1882-1912). This was followed in 1997 by research on Vryburg hepatosis, another area-specific mineral imbalance-related disease in young calves reared on manganese-rich soil derived from the weathering of dolomitic (carbonate) rock formations. In 1982, a totally new syndrome (osteochondrosis) manifested in, amongst others, areas in South Africa where aphosphorosis was rife...
July 27, 2016: Onderstepoort Journal of Veterinary Research
https://www.readbyqxmd.com/read/27540113/during-hcv-and-hcv-hiv-infection-elevated-plasma-autotaxin-is-associated-with-lpa-and-markers-of-immune-activation-that-normalize-during-ifn-free-hcv-therapy
#17
Lenche Kostadinova, Carey Shive, Chelsey Judge, Elizabeth Zebrowski, Anita Compan, Kelsey Rife, Amy Hirsch, Yngve Falck-Ytter, Dannie Schlatzer, Xiaolin Li, Mark Chance, Benigno Rodriguez, Daniel L Popkin, Donald D Anthony
BACKGROUND:  Immune activation predicts morbidity during HCV and HIV infection, though mechanisms underlying immune activation are unclear. Plasma autotaxin and its enzymatic product, lysophosphatidic-acid (LPA), are elevated during HCV infection, and LPA activates immunocytes, but whether this contributes to immune activation is unknown. METHODS:  We evaluated plasma autotaxin, IL-6, sCD14, sCD163, and Mac2-Binding Protein (Mac2BP) during HCV, HIV and HCV-HIV infection, and in uninfected controls, before and after HIV ART and IFN-free HCV therapy...
August 17, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27512822/reasoning-versus-association-in-animal-cognition-current-controversies-and-possible-ways-forward
#18
Tom Beckers, Jan De Houwer, Dominic Michael Dwyer
The study of animal cognition is rife with controversy, and among the most long-standing and most intensely debated controversies in the field is the question of the extent to which the behavior of nonhuman animals can be fully understood on the basis of purely associative principles, or whether some behaviors exhibited by animals necessitate the assumption of inferential capacities in animals that defy an associative explanation. Remarkably, the continuing debate on the topic seems to be spawning little genuine progress in terms of substantial accumulation of new, generally accepted insights...
August 2016: Journal of Comparative Psychology
https://www.readbyqxmd.com/read/27498603/right-to-property-inheritance-and-contract-and-persons-with-mental-illness
#19
Dinesh Bhugra, Soumitra Pathare, Rajlaxmi Joshi, Renuka Nardodkar, Julio Torales, Edgardo Juan L Tolentino, Rubens Dantas, Antonio Ventriglio
Discrimination against people with mental illness is rife across the globe. Among different types of discrimination is the policy in many countries where persons with mental illness are forbidden to inherit property, and they are not able to enter into a contract in a large number of countries. Using various databases, legislations dealing with law of contract, law of succession/inheritance, and law relating to testamentary capacity (wills) of all UN Member states (193 countries) were studied. With respect to federal countries, the laws of the most populous state as a representative state in the respective country were studied...
August 2016: International Review of Psychiatry
https://www.readbyqxmd.com/read/27492247/within-and-beyond-the-communal-turn-to-informed-consent-in-industry-sponsored-pharmacogenetics-research-merits-and-challenges-of-community-advisory-boards
#20
REVIEW
Hojjat Soofi, Evert van Leeuwen
The one-size-fits-all paradigm of drug development fails to address inter-individual variability in drug response. Pharmacogenetics research aims at studying the role of genotypic differences in drug response. Recently, the pharmaceutical industry has shown interest to embed pharmacogenetics studies in the process of drug development. Nevertheless, population-based and commercial aspects of such future-oriented studies pose challenges for individually based informed consent (IC). As an exemplar of the communal turn to IC procedures, community advisory boards (CABs) have been integrated into different types of medical research...
October 2016: Journal of Community Genetics
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