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JOURNAL ARTICLE
Hiroaki Horiyama, Waka Fujimoto, Keisuke Kojiro, Takafumi Itoh, Hiromu Kajita, Yuzo Furuta
A method to more easily separate vascular bundles and parenchyma was investigated for the purpose of proposing a sustainable and advanced utilization of oil palm trunk (OPT). In addition, particleboard made from vascular bundles was produced as one of the effective ways to utilize the obtained vascular bundles. The following results were obtained. A Zephyr rolling equipment was used for separation, and it was found that the vascular bundles could be easily separated with the veneer in a dry state. SEM observations showed that the vascular bundles could be separated while maintaining the tissue structure...
October 3, 2023: Bioresources and Bioprocessing
#2
JOURNAL ARTICLE
Zixiang Li, Rufeng Ye, Qian He, Jiashuo Lu, Yanting Sun, Xiujian Sun, Siyuan Tang, Shuyang Hu, Jingrui Chai, Linghui Kong, Xiaoning Liu, Jing Chen, Yun Fang, Yingjie Lan, Qiong Xie, Jinggen Liu, Liming Shao, Wei Fu, Yujun Wang, Wei Li
Research into kappa opioid receptor (KOR) agonists with attenuated central-nervous-system side effects is a critical focus for developing productive and safe analgesics. Herein, a series of ortho -substituted N -cyclopropylmethyl-7α-phenyl-6,14- endo ethano-tetrahydronorthebaines were designed, synthesized, and subjected to bioassays. Compound 7a exhibited high subtype selectivity and potent agonistic activity toward KOR (KOR, K i = 3.9 nM, MOR/KOR = 270, DOR/KOR = 1075; [35 S]GTPγS binding, EC50 = 3...
April 22, 2024: Journal of Medicinal Chemistry
#3
Myongin Oh, Maximilian Shen, Ruibin Liu, Lidiya Stavitskaya, Jana Shen
Opioids are small-molecule agonists of µ -opioid receptor ( µ OR), while reversal agents such as naloxone are antagonists of mOR. Here we developed machine learning models to classify the intrinsic activities of ligands at the human µ OR. We first manually curated a database of 983 small molecules with measured E max values at the human µ OR. Analysis of the chemical space allowed identification of dominant scaffolds and structurally similar agonists and antagonists. Decision tree models and directed message passing neural networks (MPNNs) were then trained to classify agonistic and antagonistic ligands...
April 10, 2024: bioRxiv
#4
JOURNAL ARTICLE
J Mor, S K Sharma
Only limited enhancement in room-temperature ionic-conductivity for poly(ethylene oxide), PEO, based electrolytes is possible due to coupling between ionic-conductivity and segmental relaxation. In the present study, we have achieved ionic-conductivity of 1.07 × 10-3 and 6.20 × 10-4 S cm-1 at 313 and 298 K, respectively, by adding 45 wt% of succinonitrile (SN) in PEO having low LiTFSI loading (Li : EO = 1 : 20). This enhancement in the ionic-conductivity is attributed to faster ion transport (diffusion coefficient, D = 3...
April 19, 2024: Physical Chemistry Chemical Physics: PCCP
#5
JOURNAL ARTICLE
Efrat Bucris, Victoria Indenbaum, Tal Levin, Yara Kanaaneh, Keren Friedman, Tatyana Kushnir, Rivka Sheffer, Michal Savion, Matanelle Salama, Noa Di-Castro, Kozita Labay, Maya Butera, Baraah Shihada, Zohar Mor, Yaniv Lustig, Neta S Zuckerman
Between late 2023 and early 2024, two measles outbreaks occurred in Israel, each caused by importation of measles virus strains of respective B3 and D8 genotypes. In this study, we validate transmission pathways uncovered by epidemiological investigations using a rapid molecular approach, based on complete measles virus genomes. The presented findings support this rapid molecular approach in complementing conventional contact tracing and highlight its potential for informing public health interventions.
April 2024: Euro Surveillance
#6
JOURNAL ARTICLE
Caroline M Nievergelt, Adam X Maihofer, Elizabeth G Atkinson, Chia-Yen Chen, Karmel W Choi, Jonathan R I Coleman, Nikolaos P Daskalakis, Laramie E Duncan, Renato Polimanti, Cindy Aaronson, Ananda B Amstadter, Soren B Andersen, Ole A Andreassen, Paul A Arbisi, Allison E Ashley-Koch, S Bryn Austin, Esmina Avdibegoviç, Dragan Babić, Silviu-Alin Bacanu, Dewleen G Baker, Anthony Batzler, Jean C Beckham, Sintia Belangero, Corina Benjet, Carisa Bergner, Linda M Bierer, Joanna M Biernacka, Laura J Bierut, Jonathan I Bisson, Marco P Boks, Elizabeth A Bolger, Amber Brandolino, Gerome Breen, Rodrigo Affonseca Bressan, Richard A Bryant, Angela C Bustamante, Jonas Bybjerg-Grauholm, Marie Bækvad-Hansen, Anders D Børglum, Sigrid Børte, Leah Cahn, Joseph R Calabrese, Jose Miguel Caldas-de-Almeida, Chris Chatzinakos, Sheraz Cheema, Sean A P Clouston, Lucía Colodro-Conde, Brandon J Coombes, Carlos S Cruz-Fuentes, Anders M Dale, Shareefa Dalvie, Lea K Davis, Jürgen Deckert, Douglas L Delahanty, Michelle F Dennis, Frank Desarnaud, Christopher P DiPietro, Seth G Disner, Anna R Docherty, Katharina Domschke, Grete Dyb, Alma Džubur Kulenović, Howard J Edenberg, Alexandra Evans, Chiara Fabbri, Negar Fani, Lindsay A Farrer, Adriana Feder, Norah C Feeny, Janine D Flory, David Forbes, Carol E Franz, Sandro Galea, Melanie E Garrett, Bizu Gelaye, Joel Gelernter, Elbert Geuze, Charles F Gillespie, Slavina B Goleva, Scott D Gordon, Aferdita Goçi, Lana Ruvolo Grasser, Camila Guindalini, Magali Haas, Saskia Hagenaars, Michael A Hauser, Andrew C Heath, Sian M J Hemmings, Victor Hesselbrock, Ian B Hickie, Kelleigh Hogan, David Michael Hougaard, Hailiang Huang, Laura M Huckins, Kristian Hveem, Miro Jakovljević, Arash Javanbakht, Gregory D Jenkins, Jessica Johnson, Ian Jones, Tanja Jovanovic, Karen-Inge Karstoft, Milissa L Kaufman, James L Kennedy, Ronald C Kessler, Alaptagin Khan, Nathan A Kimbrel, Anthony P King, Nastassja Koen, Roman Kotov, Henry R Kranzler, Kristi Krebs, William S Kremen, Pei-Fen Kuan, Bruce R Lawford, Lauren A M Lebois, Kelli Lehto, Daniel F Levey, Catrin Lewis, Israel Liberzon, Sarah D Linnstaedt, Mark W Logue, Adriana Lori, Yi Lu, Benjamin J Luft, Michelle K Lupton, Jurjen J Luykx, Iouri Makotkine, Jessica L Maples-Keller, Shelby Marchese, Charles Marmar, Nicholas G Martin, Gabriela A Martínez-Levy, Kerrie McAloney, Alexander McFarlane, Katie A McLaughlin, Samuel A McLean, Sarah E Medland, Divya Mehta, Jacquelyn Meyers, Vasiliki Michopoulos, Elizabeth A Mikita, Lili Milani, William Milberg, Mark W Miller, Rajendra A Morey, Charles Phillip Morris, Ole Mors, Preben Bo Mortensen, Mary S Mufford, Elliot C Nelson, Merete Nordentoft, Sonya B Norman, Nicole R Nugent, Meaghan O'Donnell, Holly K Orcutt, Pedro M Pan, Matthew S Panizzon, Gita A Pathak, Edward S Peters, Alan L Peterson, Matthew Peverill, Robert H Pietrzak, Melissa A Polusny, Bernice Porjesz, Abigail Powers, Xue-Jun Qin, Andrew Ratanatharathorn, Victoria B Risbrough, Andrea L Roberts, Alex O Rothbaum, Barbara O Rothbaum, Peter Roy-Byrne, Kenneth J Ruggiero, Ariane Rung, Heiko Runz, Bart P F Rutten, Stacey Saenz de Viteri, Giovanni Abrahão Salum, Laura Sampson, Sixto E Sanchez, Marcos Santoro, Carina Seah, Soraya Seedat, Julia S Seng, Andrey Shabalin, Christina M Sheerin, Derrick Silove, Alicia K Smith, Jordan W Smoller, Scott R Sponheim, Dan J Stein, Synne Stensland, Jennifer S Stevens, Jennifer A Sumner, Martin H Teicher, Wesley K Thompson, Arun K Tiwari, Edward Trapido, Monica Uddin, Robert J Ursano, Unnur Valdimarsdóttir, Miranda Van Hooff, Eric Vermetten, Christiaan H Vinkers, Joanne Voisey, Yunpeng Wang, Zhewu Wang, Monika Waszczuk, Heike Weber, Frank R Wendt, Thomas Werge, Michelle A Williams, Douglas E Williamson, Bendik S Winsvold, Sherry Winternitz, Christiane Wolf, Erika J Wolf, Yan Xia, Ying Xiong, Rachel Yehuda, Keith A Young, Ross McD Young, Clement C Zai, Gwyneth C Zai, Mark Zervas, Hongyu Zhao, Lori A Zoellner, John-Anker Zwart, Terri deRoon-Cassini, Sanne J H van Rooij, Leigh L van den Heuvel, Murray B Stein, Kerry J Ressler, Karestan C Koenen
Post-traumatic stress disorder (PTSD) genetics are characterized by lower discoverability than most other psychiatric disorders. The contribution to biological understanding from previous genetic studies has thus been limited. We performed a multi-ancestry meta-analysis of genome-wide association studies across 1,222,882 individuals of European ancestry (137,136 cases) and 58,051 admixed individuals with African and Native American ancestry (13,624 cases). We identified 95 genome-wide significant loci (80 new)...
April 18, 2024: Nature Genetics
#7
JOURNAL ARTICLE
Chryso Th Pallari, Souzana Achilleos, Annalisa Quattrocchi, John Gabel, Elena Critselis, Maria Athanasiadou, Mohammad Reza Rahmanian Haghighi, Stefania Papatheodorou, Tianyu Liu, Andreas Artemiou, Jose M Rodriguez-Llanes, Catherine M Bennett, Claudia Zimmermann, Eva Schernhammer, Natalia Bustos Sierra, Reindert Ekelson, Jackeline Lobato, Laylla Macedo, Laust Hvas Mortensen, Julia Critchley, Lucy Goldsmith, Gleb Denissov, Nolwenn Le Meur, Levan Kandelaki, Kostas Athanasakis, Binyamin Binyaminy, Tamar Maor, Fabrizio Stracci, Giuseppe Ambrosio, Kairat Davletov, Nataliya Glushkova, Cyndy Martial, Marie Chan Sun, Terje P Hagen, Mario Chong, Manuel Barron, Błażej Łyszczarz, Ivan Erzen, Pedro Arcos Gonzalez, Bo Burström, Nataliia Pidmurniak, Olesia Verstiuk, Qian Huang, Antonis Polemitis, Andreas Charalambous, Christiana A Demetriou
INTRODUCTION: To examine the impact of the COVID-19 pandemic on mortality, we estimated excess all-cause mortality in 24 countries for 2020 and 2021, overall and stratified by sex and age. METHODS: Total, age-specific and sex-specific weekly all-cause mortality was collected for 2015-2021 and excess mortality for 2020 and 2021 was calculated by comparing weekly 2020 and 2021 age-standardised mortality rates against expected mortality, estimated based on historical data (2015-2019), accounting for seasonality, and long-term and short-term trends...
April 18, 2024: BMJ Global Health
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JOURNAL ARTICLE
Edna J Santos, Hamid I Akbarali, Eric W Bow, Dana R Chambers, Eugene S Gutman, Arthur E Jacobson, Minho Kang, Young K Lee, Joshua A Lutz, Kenner C Rice, Agnieszka Sulima, S Stevens Negus
Low efficacy mu opioid receptor (MOR) agonists may serve as novel candidate analgesics with improved safety relative to high-efficacy opioids. This study used a recently validated assay of pain-depressed behavior in mice to evaluate a novel series of MOR-selective C9-substituted phenylmorphan opioids with graded MOR efficacies. Intraperitoneal injection of dilute lactic acid (IP acid) served as a noxious stimulus to depress locomotor activity by mice in an activity chamber composed of two compartments connected by an obstructed door...
April 18, 2024: Journal of Pharmacology and Experimental Therapeutics
#9
JOURNAL ARTICLE
Comparison of flanged polypropylene scleral intraocular lens fixation with scleral sutured fixation.
Shani Levy-Neuman, Liat Mendel, Asaf Achiron, Amir Bukelman, Tamir Weinberg, Haggay Avizemer, Mor Shlezinger, Arie L Marcovich, Guy Kleinmann
OBJECTIVE: To compare the outcome of 2 intraocular lens (IOL) scleral fixation techniques: double-flanged polypropylene and Hoffman scleral pocket. METHODS: Retrospective case series of all patients who underwent IOL scleral fixation by either the flange (flange group) or Hoffman scleral pocket (Hoffman group) techniques at the Kaplan Medical Center and the Edith Wolfson Medical Center. RESULTS: A total of 140 patients were included (63 flange, 77 Hoffman)...
April 15, 2024: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
#10
EDITORIAL
Mor-Li Hartman, Mohammed S Razzaque
No abstract text is available yet for this article.
2024: Frontiers in Endocrinology
#11
JOURNAL ARTICLE
Fukai Feng, Chaoqun Ma, Sumei Han, Xiao Ma, Caihong He, Huaifang Zhang, Wenbin Cao, Xiangmin Meng, Jing Xia, Lijie Zhu, Yahui Tian, Qi Wang, Qinbai Yun, Qipeng Lu
Constructing amorphous/intermetallic (A/IMC) heterophase structures by breaking the highly ordered IMC phase with disordered amorphous phase is an effective way to improve the electrocatalytic performance of noble metal-based IMC electrocatalysts because of the optimized electronic structure and abundant heterophase boundaries as active sites. In this study, we report the synthesis of ultrathin A/IMC PtPbBi nanosheets (NSs) for boosting hydrogen evolution reaction (HER) and alcohol oxidation reactions. The resulting A/IMC PtPbBi NSs exhibit a remarkably low overpotential of only 25 mV at 10 mA cm-2 for the HER in an acidic electrolyte, together with outstanding stability for 100 h...
April 15, 2024: Angewandte Chemie
#12
JOURNAL ARTICLE
Adi Barak, Mor Safyon, Liron Ben-Ezra
In this qualitative study we explore the concept of ideological meaning-making, with a focus on political radicalization and its relation to the process of meaning-making. Through interviews with 33 individuals who experienced the loss of a close family member in the Israeli-Palestinian conflict and subsequently became politically radicalized, four key themes emerged: preliminary decision, zoom out, mission, and radicalized self. Participants initially stabilize their beliefs through a preliminary ideological decision, followed by adopting a broader perspective (zoom out) that encompasses the political context...
April 15, 2024: Death Studies
#13
JOURNAL ARTICLE
Steffany Villaseñor, Mor Grinstein
Two-photon microscopy has emerged as a potent tool for evaluating deep tissue cells and characterizing the alignment of the extracellular matrix (ECM) in various biological systems. This technique relies on nonlinear light-matter interactions to detect two distinct signals: the second harmonic generated (SHG) diffusion signal, which facilitates the visualization of collagen fibers and their orientation, and the near-infrared excitation signal for imaging ultraviolet excited autofluorescence. SHG imaging proves especially effective in visualizing collagen fibers due to the non-centrosymmetric crystalline structure of fibrillar collagen I...
March 29, 2024: Journal of Visualized Experiments: JoVE
#14
JOURNAL ARTICLE
Nataliia Konstantinova, Eliana Mor, Eline Verhelst, Jonah Nolf, Kenzo Vereecken, Feng Wang, Daniel Van Damme, Bert De Rybel, Matouš Glanc
The molecular mechanisms guiding oriented cell divisions in the root vascular tissues of Arabidopsis thaliana are still poorly characterised. By overlapping bulk and single-cell transcriptomic datasets, we unveiled TETRASPANIN1 (TET1) as a putative regulator in this process. TET1 is expressed in root vascular cells, and loss-of-function mutants contain fewer vascular cell files. We further generated and characterised a CRISPR deletion mutant and showed, unlike previously described mutants, that the full knock out is additionally missing endodermal cells in a stochastic way...
2024: Physiologia Plantarum
#15
JOURNAL ARTICLE
Junhua Li, Chao Wu, Zhen Wang, Haoyan Meng, Qi Zhang, Ying Tang, Anqi Zou, Yiming Zhang, Haoyin Zhong, Shibo Xi, Junmin Xue, Xiaopeng Wang, Jiagang Wu
The anodic methanol oxidation reaction (MOR) plays a crucial role in coupling with the cathodic hydrogen evolution reaction (HER) and enables the sustainable production of the high-valued formate. Nickel-based hydroxide (Ni(OH)2) as MOR electrocatalyst has attracted enormous attention. However, the key factor determining the intrinsic catalytic activity remains unknown, which significantly hinders the further development of Ni(OH)2 electrocatalyst. Here, we found that the dx2-y2 electronic state within antibonding bands plays a decisive role in the whole MOR process...
April 15, 2024: Angewandte Chemie
#16
JOURNAL ARTICLE
Ofer Reiter, Mor Miodovnik, Emily Avitan-Hersh, Nadav Astman, Nir Nathanson, Ayelet Rishpon, Aviv Barzilai, Alon Scope
INTRODUCTION: Early detection may lead to reduced morbidity and mortality from melanoma. This study aims to establish guidelines for selecting patients suitable for digital monitoring of skin lesions. METHODS: A literature review was conducted, followed by consensus among experts appointed by the Israeli Dermatology Association. RESULTS: Two effective methods for early melanoma diagnosis were identified: Total-body photography (TBP) and digital dermoscopy...
April 2024: Harefuah
#17
JOURNAL ARTICLE
Nadine Hochrainer, Pawel Serafin, Sara D'Ingiullo, Adriano Mollica, Sebastian Granica, Marek Brytan, Patrycja Kleczkowska, Mariana Spetea
Diverse chemical and pharmacological strategies are currently being explored to minimize the unwanted side effects of currently used opioid analgesics while achieving effective pain relief. The use of multitarget ligands with activity at more than one receptor represents a promising therapeutic approach. We recently reported a bifunctional peptide-based hybrid LENART01 combining dermorphin and ranatensin pharmacophores, which displays activity to the mu-opioid receptor (MOR) and dopamine D2 receptor (D2R) in rat brains and spinal cords...
April 3, 2024: International Journal of Molecular Sciences
#18
JOURNAL ARTICLE
Rashid Hameed, Muhammad Tahir, Safeer Abbas, Haseeb Ullah Sheikh, Syed Minhaj Saleem Kazmi, Muhammad Junaid Munir
The recycling of construction and demolition waste (CDW) for the extraction of recycled concrete aggregates (RCAs) to be used to produce recycled aggregate concrete (RAC) is widely acknowledged internationally. However, CDW not only contains concrete debris but may also contain burnt clay bricks. The recycling of such CDW without the segregation of different components would result in recycled aggregates having different proportions of concrete and brick aggregates. The utilization of these aggregates in concrete requires a detailed investigation of their mechanical and durability properties...
March 29, 2024: Materials
#19
JOURNAL ARTICLE
Juris Grinins, Guntis Sosins, Prans Brazdausks, Janis Zicans
In this study, silver birch ( Betula pendula ) and Scots pine ( Pinus sylvestris ) wood planks (1000 × 100 × 25 mm) were thermally modified in pilot-scale equipment. Research extended our knowledge of the thermal modification (TM) process in a closed system under nitrogen pressure, as well as how process parameters affect the chemical composition and mechanical strength of wood. Various TM regimes were selected-maximum temperature (150-180 °C), modification time (30-180 min), and initial nitrogen pressure (3-6 bar)...
March 22, 2024: Materials
#20
JOURNAL ARTICLE
Masoumeh Tavakoli-Yaraki, Aida Abbasi, Fatemeh Nejat Pishkenari, Saeed Baranipour, Alireza Jahangirifard, Seyed Bashir Mirtajani, Zahra Noorani Mejareh, Mohammad Amin Vaezi, Jila Yavarian, Bahare Abdollahi, Talat Mokhtari-Azad, Vahid Salimi
BACKGROUND: This study aims to explore the potential of utilizing the expression levels of cannabinoid receptor 2 (CB2), μ-opioid receptor (MOR), MCP-1, IL-17, IFN-γ, and osteopontin as predictors for the severity of SARS-CoV-2 infection. The overarching goal is to delineate the pathogenic mechanisms associated with SARS-CoV-2. METHODS: Using quantitative Real-time PCR, we analyzed the gene expression levels of CB2 and MOR in nasopharynx specimens obtained from patients diagnosed with SARS-CoV-2 infection, with 46 individuals classified as having severe symptoms and 46 as non-severe...
April 12, 2024: BMC Infectious Diseases
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