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https://www.readbyqxmd.com/read/28442223/diurnal-cortisol-after-early-institutional-care-age-matters
#1
Jessica E Flannery, Laurel J Gabard-Durnam, Mor Shapiro, Bonnie Goff, Christina Caldera, Jennifer Louie, Dylan G Gee, Eva H Telzer, Kathryn L Humphreys, Daniel S Lumian, Nim Tottenham
Several studies have shown that young children who have experienced early caregiving adversity (e.g. previously institutionalization (PI)) exhibit flattened diurnal cortisol slopes; however, less is known about how these patterns might differ between children and adolescents, since the transition between childhood and adolescence is a time of purported plasticity in the hypothalamic-pituitary-adrenal (HPA) axis. PI youth experience a massive improvement in caregiving environment once adopted into families; therefore we anticipated that a developmental increase in HPA axis plasticity during adolescence might additionally allow for an enhanced enrichment effect by the adoptive family...
March 21, 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/28434249/pulmonary-tuberculosis-is-associated-with-biomass-fuel-use-among-rural-women-in-pakistan-an-age-and-residence-matched-case-control-study
#2
Unaib Rabbani, Ambreen Sahito, Asaad Ahmed Nafees, Ambreen Kazi, Zafar Fatmi
Facility-based, age- and residential area-matched case-control study was conducted in Sindh, Pakistan to determine association between biomass fuel use for cooking and pulmonary tuberculosis (TB). Cases were women with pulmonary TB, and controls were those suffering from other diseases. Current users of biomass fuel were at higher risk of pulmonary TB (adjusted matched odds ratio [mOR] = 3.0; 95% CI = 1.1-4.9) compared with nonusers. In comparison with former biomass users (women not using biomass for >10 years), recent biomass users (women who switched from biomass to nonbiomass ≤10 years ago), and current (lifetime) users were at a higher risk in a dose-response manner (adjusted mOR = 2...
April 2017: Asia-Pacific Journal of Public Health
https://www.readbyqxmd.com/read/28432564/unintended-pregnancy-and-contraceptive-use-among-women-veterans-the-ecuun-study
#3
Sonya Borrero, Lisa S Callegari, Xinhua Zhao, Maria K Mor, Florentina E Sileanu, Galen Switzer, Susan Zickmund, Donna L Washington, Laurie C Zephyrin, E Bimla Schwarz
BACKGROUND: Little is known about contraceptive care for the growing population of women veterans who receive care in the Veterans Administration (VA) healthcare system. OBJECTIVE: To determine rates of contraceptive use, unmet need for prescription contraception, and unintended pregnancy among reproductive-aged women veterans. DESIGN AND PARTICIPANTS: We conducted a cross-sectional, telephone-based survey with a national sample of 2302 women veterans aged 18-44 years who had received primary care in the VA within the prior 12 months...
April 21, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28432086/comparing-two-regimens-of-in-travaginal-misoprostol-with-intravaginal-gemeprost-for-second-trimesterpregnancy-termination-a-randomised-controlled-trial
#4
Daniel Seow Choon Koh, Esther Pei Jing Ang, Jurja Chua Coyuco, Hua Zhen Teo, Xiaoling Huang, Xing Wei, Mor Jack Ng, Serene Liqing Lim, Kok Hian Tan
AIM: To compare the efficacy and safety of intravaginal misoprostol 200 µg, 400 µg and gemeprost regimens for second-trimester termination of pregnancy (TOP). METHODS: A three-armed randomised controlled trial (Clinical Trial Certificate 1100015) where 116 women undergoing second-trimester TOP were given intravaginal misoprostol 200 µg (n=37), misoprostol 400 µg (n=40) or gemeprost 1 mg (n=39) at 4-hour intervals until abortion occurred with a maximum of five doses...
April 21, 2017: Journal of Family Planning and Reproductive Health Care
https://www.readbyqxmd.com/read/28428838/a-national-strategic-plan-for-reducing-the-burden-of-sexually-transmitted-infections-in-israel-by-the-year-2025
#5
Daniel Chemtob, Dan Gandacu, Zohar Mor, Itamar Grotto, Emilia Anis, Elliot Rosenberg
BACKGROUND: There is on ongoing debate in the literature regarding the real burden of STIs (sexually transmitted infections) in Western countries and the proper strategies needed to estimate and to prevent them. Our purpose is to present an evidence-based national strategic plan for STI prevention in Israel through assessing the current burden of illness, leading international preventive strategies, and practical policymaking experience. METHODS: Epidemiologic and health policy data on STIs were analyzed from various sources: a) systematic national surveillance data for the years 2002-2014; b) the international scientific literature (published between 2002-16; keywords: Sexually Transmitted Diseases (STD) (or STI) AND prevention AND intervention AND gonorrhea OR chlamydia OR syphilis; c) internal Ministry of Health (MOH) analyses and reports, and d) expert opinion...
2017: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/28422066/diabetogenic-effects-of-ochratoxin-a-in-female-rats
#6
Firdevs Mor, Omur Sengul, Senay Topsakal, Mehmet Akif Kilic, Ozlem Ozmen
In this study, the diabetogenic effects of long term Ochratoxin A (OTA) administration in rats were investigated, and its role in the etiology of diabetes mellitus (DM) was examined utilizing 42 female Wistar rats for these purposes. The rats were divided into three different study and control groups according to the duration of the OTA administration. The rats received 45 μg OTA daily in their feed for 6, 9 and 24 weeks, respectively. Three control groups were also used for the same time periods. Blood and pancreatic tissue samples were collected during the necropsy at the end of the 6, 9 and 24 weeks...
April 19, 2017: Toxins
https://www.readbyqxmd.com/read/28419414/association-between-aggressive-care-and-bereaved-families-evaluation-of-end-of-life-care-for-veterans-with-non-small-cell-lung-cancer-who-died-in-veterans-affairs-facilities
#7
Mary Ersek, Susan C Miller, Todd H Wagner, Joshua M Thorpe, Dawn Smith, Cari R Levy, Risha Gidwani, Katherine Faricy-Anderson, Karl A Lorenz, Bruce Kinosian, Vincent Mor
BACKGROUND: To the authors' knowledge, little is known regarding the relationship between patients' and families' satisfaction with aggressive end-of-life care. Herein, the authors examined the associations between episodes of aggressive care (ie, chemotherapy, mechanical ventilation, acute hospitalizations, and intensive care unit admissions) within the last 30 days of life and families' evaluations of end-of-life care among patients with non-small cell lung cancer (NSCLC). METHODS: A total of 847 patients with NSCLC (34% of whom were aged <65 years) who died in a nursing home or intensive care, acute care, or hospice/palliative care (HPC) unit at 1 of 128 Veterans Affairs Medical Centers between 2010 and 2012 were examined...
April 17, 2017: Cancer
https://www.readbyqxmd.com/read/28419202/genomic-characterization-of-usa300-mrsa-to-evaluate-intraclass-transmission-and-recurrence-of-ssti-among-high-risk-military-trainees
#8
Eugene V Millar, Gregory K Rice, Emad M Elassal, Carey D Schlett, Jason W Bennett, Cassie L Redden, Deepika Mor, Natasha N Law, David R Tribble, Theron Hamilton, Michael W Ellis, Kimberly A Bishop-Lilly
Background.: Military trainees are at increased risk for methicillin-resistant Staphylococcus aureus (MRSA) skin and soft tissue infection (SSTI). Whole genome sequencing (WGS) can refine our understanding of MRSA transmission and microevolution in congregate settings. Methods.: We conducted a prospective case-control study of SSTI among US Army Infantry trainees at Fort Benning, GA from July 2012-December 2014. We identified clusters of USA300 MRSA SSTI within select training classes and performed WGS on clinical isolates...
April 17, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28418589/a-distinct-cutaneous-microbiota-pofile-in-autoimmune-bullous-disease-patients
#9
Mor Miodovnik, Axel Künstner, Ewan A Langan, Detlef Zillikens, Regine Gläser, Eli Sprecher, John F Baines, Enno Schmidt, Saleh M Ibrahim
Bullous Pemphigoid (BP) is the most common autoimmune blistering disease in Europe. As both the incidence of the disease and the relative proportion of the elderly population continue to rise, it represents a significant medical burden. Whereas some progress has been achieved in defining genetic risk factors for autoimmune blistering diseases, no environmental agent has been conclusively identified. Emerging evidence suggests that host immunity may influence the skin microbiota while the latter modulates cutaneous immunity...
April 18, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28415063/neuron-restrictive-silencer-factor-mediated-downregulation-of-%C3%AE-opioid-receptor-contributes-to-the-reduced-morphine-analgesia-in-bone-cancer-pain
#10
Chao Zhu, Jun Tang, Tan Ding, Lei Chen, Wei Wang, Xiao-Peng Mei, Xiao-Tao He, Wen Wang, Li-Dong Zhang, Yu-Lin Dong, Zhuo-Jing Luo
Bone cancer pain has been reported to have unique mechanisms and is resistant to morphine treatment. Recent studies have indicated that neuron-restrictive silencer factor (NRSF) plays a crucial role in modulating the expression of the μ-opioid receptor (MOR) gene. The present study elucidates the regulatory mechanisms of MOR and its ability to affect bone cancer pain. Using a sarcoma-inoculated murine model, pain behaviors that represent continuous or breakthrough pain were evaluated. Expression of NRSF in the dorsal root ganglion (DRG) and spinal dorsal horn was quantified at the transcriptional and translational levels, respectively...
May 2017: Pain
https://www.readbyqxmd.com/read/28412431/3d-morphological-changes-in-lv-and-rv-during-lvad-ramp-studies
#11
Karima Addetia, Nir Uriel, Francesco Maffessanti, Gabriel Sayer, Sirtaz Adatya, Gene H Kim, Nitasha Sarswat, Savitri Fedson, Diego Medvedofsky, Eric Kruse, Keith Collins, Daniel Rodgers, Takayoshi Ota, Valluvan Jeevanandam, Victor Mor-Avi, Daniel Burkhoff, Roberto M Lang
OBJECTIVES: The purpose of this study was to investigate the differential impact of the 2 most commonly available left ventricular assist device (LVAD) types on the right (RV) and left (LV) ventricles using 3-dimensional (3D) echocardiography-based analysis of ventricular morphology. BACKGROUND: LVADs have emerged as common therapy for advanced heart failure. Recent data suggest that the heart responds differently to speed settings in the 2 main devices available (HeartMate II [HMII], St Jude Medical, Pleasanton, California, and HVAD, HeartWare International, Framingham, Massachusetts)...
April 7, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28407740/mu-opioid-receptor-and-delta-opioid-receptor-differentially-regulate-microglial-inflammatory-response-to-control-proopiomelanocortin-neuronal-apoptosis-in-the-hypothalamus-effects-of-neonatal-alcohol
#12
Pallavi Shrivastava, Miguel A Cabrera, Lucy G Chastain, Nadka I Boyadjieva, Shaima Jabbar, Tina Franklin, Dipak K Sarkar
BACKGROUND: Opioid receptors are known to control neurotransmission of various peptidergic neurons, but their potential role in regulation of microglia and neuronal cell communications is unknown. We investigated the role of mu-opioid receptors (MOR) and delta-opioid receptors (DOR) on microglia in the regulation of apoptosis in proopiomelanocortin (POMC) neurons induced by neonatal ethanol in the hypothalamus. METHODS: Neonatal rat pups were fed a milk formula containing ethanol or control diets between postnatal days 2-6...
April 14, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28404542/immediate-mood-scaler-tracking-symptoms-of-depression-and-anxiety-using-a-novel-mobile-mood-scale
#13
Mor Nahum, Thomas M Van Vleet, Vikaas S Sohal, Julie J Mirzabekov, Vikram R Rao, Deanna L Wallace, Morgan B Lee, Heather Dawes, Alit Stark-Inbar, Joshua Thomas Jordan, Bruno Biagianti, Michael Merzenich, Edward F Chang
BACKGROUND: Mood disorders are dynamic disorders characterized by multimodal symptoms. Clinical assessment of symptoms is currently limited to relatively sparse, routine clinic visits, requiring retrospective recollection of symptoms present in the weeks preceding the visit. Novel advances in mobile tools now support ecological momentary assessment of mood, conducted frequently using mobile devices, outside the clinical setting. Such mood assessment may help circumvent problems associated with infrequent reporting and better characterize the dynamic presentation of mood symptoms, informing the delivery of novel treatment options...
April 12, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28401841/positive-valence-bias-and-parent-child-relationship-security-moderate-the-association-between-early-institutional-caregiving-and-internalizing-symptoms
#14
Michelle R Vantieghem, Laurel Gabard-Durnam, Bonnie Goff, Jessica Flannery, Kathryn L Humphreys, Eva H Telzer, Christina Caldera, Jennifer Y Louie, Mor Shapiro, Niall Bolger, Nim Tottenham
Institutional caregiving is associated with significant deviations from species-expected caregiving, altering the normative sequence of attachment formation and placing children at risk for long-term emotional difficulties. However, little is known about factors that can promote resilience following early institutional caregiving. In the current study, we investigated how adaptations in affective processing (i.e., positive valence bias) and family-level protective factors (i.e., secure parent-child relationships) moderate risk for internalizing symptoms in previously institutionalized (PI) youth...
May 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28399457/cumulative-pain-related-stress-and-developmental-outcomes-among-low-risk-preterm-infants-at-one-year-corrected-age
#15
Iris Morag, Ifat Rotem, Mor Frisch, Israel Hendler, Michal J Simchen, Leah Leibovitz, Ayala Maayan-Metzger, Tzipora Strauss
BACKGROUND: Extensive exposure of preterm infants to pain-related stress (PRS) at a time of physiological immaturity and rapid brain development may contribute to altered neurodevelopment. OBJECTIVE: To examine the relationship between early PRS and neurodevelopmental outcomes among low-risk very preterm infants at the age of one year corrected age (CA). METHODS: Participants included 107 infants born <32weeks gestational age (GA) and monitored prospectively at 12...
April 8, 2017: Early Human Development
https://www.readbyqxmd.com/read/28395219/synthesis-and-biological-evaluation-of-morpholine-substituted-diphenylpyrimidine-derivatives-mor-dppys-as-potent-egfr-t790m-inhibitors-with-improved-activity-toward-the-gefitinib-resistant-non-small-cell-lung-cancers-nsclc
#16
Zhendong Song, Shanshan Huang, Haiqing Yu, Yu Jiang, Changyuan Wang, Qiang Meng, Xiaohong Shu, Hunjun Sun, Kexin Liu, Yanxia Li, Xiaodong Ma
Potential new EGFR(T790M) inhibitors comprised of structurally modified diphenylpyrimidine derivatives bearing a morpholine functionality (Mor-DPPYs) were used to improve the activity and selectivity of gefitinib-resistant non-small cell lung cancer (NSCLC) treatment. This led to the identification of inhibitor 10c, which displayed high activity against EGFR(T790M/L858R) kinase (IC50 = 0.71 nM) and repressed H1975 cell replication harboring EGFR(T790M) mutations at a concentration of 0.037 μM. Inhibitor 10c demonstrated high selectivity (SI = 631...
April 2, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28394580/expanding-the-genetic-code-of-a-photoautotrophic-organism
#17
Yonatan Chemla, Mor Friedman, Mathias Heltberg, Anna Bakhrat, Elad Nagar, Rakefet Schwarz, Mogens Høgh Jensen, Lital Alfonta
The photoautotrophic freshwater cyanobacterium Synechococcus elongatus is widely used as a chassis for biotechnological applications as well as a photosynthetic bacterial model. In this study, a method for expanding the genetic code of this cyanobacterium has been established, thereby allowing the incorporation of unnatural amino acids into proteins. This was achieved through UAG stop codon suppression, using an archaeal pyrrolysyl orthogonal translation system. We demonstrate incorporation of unnatural amino acids into green fluorescent protein with 20 ± 3...
April 12, 2017: Biochemistry
https://www.readbyqxmd.com/read/28394447/mu-opioid-receptor-signaling-in-the-nucleus-accumbens-shell-increases-responsiveness-of-satiety-modulated-lateral-hypothalamus-neurons
#18
Shashank Tandon, Kristen A Keefe, Sharif A Taha
Opioid signaling in the nucleus accumbens shell (sNAcc) has been implicated in hedonic feeding and binge-eating behavior. The sNAcc projects to the lateral hypothalamus (LH), and this pathway has been suggested to modulate palatability-driven feeding behavior. In this study, we investigated the effects of sNAcc mu opioid receptor stimulation on firing rates of LH neurons in previously sated rats. Neural firing in the LH was recorded while food-deprived rats performed an operant task to obtain sweetened Intralipid (a 4% fat emulsion containing 5% sucrose) before and after bilateral sNAcc infusion of either a mu opioid receptor (MOR) agonist, [D-Ala2, N-MePhe4, Gly-ol]-enkephalin (DAMGO), or a saline control solution...
April 10, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28394408/effect-of-clostridium-difficile-prevalence-in-hospitals-and-nursing-homes-on-risk-of-infection
#19
Nina R Joyce, Eleftherios Mylonakis, Vincent Mor
OBJECTIVES: To assess the effect of facility Clostridium difficile infection (CDI) prevalence on risk of healthcare facility (HFC) acquired CDI. DESIGN: Retrospective cohort study. SETTING: Medicare fee-for-service (FFS) claims and skilled nursing facility (SNF) Minimum Data Set 3.0 assessments. PARTICIPANTS: Medicare beneficiaries with 90 days or more of no contact with a HCF before a hospital admission without a CDI diagnosis...
April 10, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28394178/a-role-of-metastable-regions-and-their-connectivity-in-the-inactivation-of-a-redox-regulated-chaperone-and-its-inter-chaperone-crosstalk
#20
Oded Rimon, Ohad Suss, Mor Goldenberg, Rosi Fassler, Ohad Yogev, Hadar Amartely, Guy Propper, Assaf Friedler, Dana Reichmann
AIMS: A recently discovered group of conditionally disordered chaperones share a very unique feature; they need to lose structure to become active as chaperones. This activation mechanism makes these chaperones particularly suited to respond to protein-unfolding stress conditions, such as oxidative unfolding. However, the role of this disorder in stress-related activation, chaperone function, and the crosstalk with other chaperone systems is not yet clear. Here, we focus on one of the members of the conditionally disordered chaperones, a thiol-redox switch of the bacterial proteostasis system, Hsp33...
April 10, 2017: Antioxidants & Redox Signaling
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