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https://www.readbyqxmd.com/read/28537715/facile-synthesis-of-cu-nicu-electrocatalysts-integrating-alloy-core-shell-and-one-dimensional-structures-for-efficient-methanol-oxidation-reaction
#1
Dengfeng Wu, Wei Zhang, Daojian Cheng
The design and development of low-cost Pt-free, high-active and durable noble-metal-free electrocatalysts for methanol electrooxidation is highly desirable but remains a challenge. Herein, unique Cu/NiCu nanowires (NWs) integrating alloy, core-shell and one-dimensional structures are prepared by a facile one-pot strategy. It is found that Ni-Cu surface alloying structure can effectively change the charge distribution of atomic configuration, core-shell structure can be optimally the usage of Ni and Cu, and one-dimensional structure can effectively enhance the charge transfer between electrode surface and active sites, making the prepared NWs as promising electrocatalysts...
May 24, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28533609/gait-abnormalities-in-patients-with-chronic-ankle-instability-can-improve-following-a-non-invasive-biomechanical-therapy-a-retrospective-analysis
#2
Shay Tenenbaum, Ofir Chechik, Jason Bariteau, Nathan Bruck, Yiftah Beer, Mazen Falah, Ganit Segal, Amit Mor, Avi Elbaz
[Purpose] The purpose of this study was to evaluate the changes in gait patterns and clinical outcomes of patients with chronic ankle instability (CAI) following treatment with a home-based non-invasive biomechanical device. [Subjects and Methods] Thirty-three patients with CAI were compared with 43 healthy controls. Patients underwent a spatiotemporal gait assessment before and three months following treatment. Clinical evaluation was recorded with SF-36 Health Survey and the Foot and Ankle Outcome Score (FAOS)...
April 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28532262/trial-of-vaginal-delivery-for-twins-is-it-safe-a-single-center-experience
#3
Dana Sadeh-Mestechkin, Yair Daykan, Mor Bostan, Ofer Markovitch, Gil Shechter-Maor, Tal Biron-Shental
PURPOSE: This study assessed our hospital protocol of vaginal delivery for twins and evaluated whether trial of vaginal delivery (unless contraindicated) was as safe as elective cesarean. Risk factors leading to failed trial of labor (TOL) were characterized to improve our ability to advise patients and select cases for TOL. METHODS: This retrospective, cohort study included women >32 weeks gestation, with twin A in cephalic presentation and no contraindications for vaginal delivery...
May 22, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28532217/integration-of-bacterial-small-rnas-in-regulatory-networks
#4
Mor Nitzan, Rotem Rehani, Hanah Margalit
Small RNAs (sRNAs) are central regulators of gene expression in bacteria, controlling target genes posttranscriptionally by base pairing with their mRNAs. sRNAs are involved in many cellular processes and have unique regulatory characteristics. In this review, we discuss the properties of regulation by sRNAs and how it differs from and combines with transcriptional regulation. We describe the global characteristics of the sRNA-target networks in bacteria using graph-theoretic approaches and review the local integration of sRNAs in mixed regulatory circuits, including feed-forward loops and their combinations, feedback loops, and circuits made of an sRNA and another regulator, both derived from the same transcript...
May 22, 2017: Annual Review of Biophysics
https://www.readbyqxmd.com/read/28530484/in%C3%A2-vivo-geometry-of-the-kissing-stent-and-covered-endovascular-reconstruction-of-the-aortic-bifurcation-configurations-in-aortoiliac-occlusive-disease
#5
Erik Groot Jebbink, Thijs G Ter Mors, Cornelis H Slump, Robert H Geelkerken, Suzanne Holewijn, Michel Mpj Reijnen
Objectives Various configurations of kissing stent (KS) configurations exist and patency rates vary. In response the covered endovascular reconstruction of the aortic bifurcation configuration was designed to minimize mismatch and improve outcome. The aim of the current study is to compare geometrical mismatch of kissing stent with the covered endovascular reconstruction of the aortic bifurcation configuration in vivo. Methods Post-operative computed tomographic data and patient demographics from 11 covered endovascular reconstruction of the aortic bifurcation and 11 matched kissing stent patients were included...
January 1, 2017: Vascular
https://www.readbyqxmd.com/read/28530309/-monitoring-units-in-departments-of-internal-medicine-frequency-impact-and-satisfaction
#6
David Raveh-Brawer, Tanya Itzekson, Ruth Henshke-Bar-Meir, Noa Sylvetsky, Reuven Friedmann, Ranana Siegman, Tanya Mor, Moshe Hersch, Amos M Yinnon, Shoshana Zevin
BACKGROUND: Due to increasing numbers of elderly, seriously ill patients and shortage of ICU beds, many hospitals have established monitoring units (MU) in their medical departments. OBJECTIVES: (1) To assess the national prevalence of MUs in medical departments; (2) to determine the outcome of consecutively admitted MU patients; (3) to evaluate patient/ family satisfaction with care. METHODS: The case control study included all 123 patients hospitalized in the MU during a 5-month period, compared with two control groups: (1) 123 patients admitted to medical departments, matched at a ratio of 1:1 by gender, age±10 years and mechanical ventilation; (2) all 52 medical patients treated in the ICU...
January 2017: Harefuah
https://www.readbyqxmd.com/read/28529734/differential-regulation-of-mouse-and-human-mu-opioid-receptor-gene-depends-on-the-single-stranded-dna-structure-of-its-promoter-and-%C3%AE-complex-protein-1
#7
Dong-Sun Lee, Ping-Yee Law, Wei Ln, Horace H Loh, Kyu Young Song, Hack Sun Choi
The Mu opioid receptor (MOR) mediates various functions of opioid-induced analgesia, euphoria and respiratory depression, and is a major target of opioid analgesics. Understanding of MOR gene expression among species is important for understanding its analgesic function in humans. In the current study, the polypyrimidine/polypurine (PPy/u) region, a key element of MOR gene expression, was compared in humans and mice. The mouse PPy/u element is highly homologous to its human element (84%), and the mouse MOR (mMOR) reporter drives luciferase activity 35-fold more effectively than the human MOR (hMOR) reporter...
May 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28526864/a-broad-spectrum-bactericidal-lipopeptide-with-anti-biofilm-properties
#8
Ohad Meir, Fadia Zaknoon, Uri Cogan, Amram Mor
Previous studies of the oligoacyllysyl (OAK) series acyl-lysyl-lysyl-aminoacyl-lysine-amide, suggested their utility towards generating robust linear lipopeptide-like alternatives to antibiotics, although to date, none exhibited potent broad-spectrum bactericidal activity. To follow up on this premise, we produced a new analog (C14KKc12K) and investigated its properties in various media. Mechanistic studies suggest that C14KKc12K uses a non-specific membrane-disruptive mode of action for rapidly reducing viability of Gram-negative bacteria (GNB) similarly to polymyxin B (PMB), a cyclic lipopeptide used as last resort antibiotic...
May 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28521884/influence-of-direct-oral-anticoagulants-on%C3%A2-rates-of-oral-anticoagulation-for-atrial%C3%A2-fibrillation
#9
Lucas N Marzec, Jingyan Wang, Nilay D Shah, Paul S Chan, Henry H Ting, Kensey L Gosch, Jonathan C Hsu, Thomas M Maddox
BACKGROUND: Oral anticoagulation (OAC) with warfarin is underused for atrial fibrillation (AF). The availability of direct oral anticoagulants (DOACs) may improve overall OAC rates in AF patients, but a large-scale evaluation of their effects has not been conducted. OBJECTIVES: This study assessed the effect of DOAC availability on overall OAC rates for nonvalvular AF. METHODS: Between April 1, 2008 and September 30, 2014, we identified 655,000 patients with nonvalvular AF and a CHA2DS2-VASc score of >1 in the National Cardiovascular Data Registry PINNACLE registry...
May 23, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28515842/casein-protein-supplementation-in-trained-men-and-women-morning-versus-evening
#10
Jose Antonio, Anya Ellerbroek, Corey Peacock, Tobin Silver
The purpose of this investigation was to determine the effects of casein supplementation (54 grams) in the morning (Casein-MOR) or evening (Casein-EVE) (90 minutes or less prior to sleep) on measures of body composition and exercise performance in trained men and women. Twenty-six healthy men and women who had been training regularly for greater than 12 months completed this 8-week study (mean±SD; Casein-MOR group [n=14, seven male, seven female]: 30.0±8.2 yr; 170.7±9.5 cm; 70.9±13.9 kg. Casein-EVE group [n=12, nine male, three female]: 28...
2017: International Journal of Exercise Science
https://www.readbyqxmd.com/read/28512665/involvement-of-%C3%A2%C2%B5-opioid-receptors-and-%C3%AE%C2%BA-opioid-receptors-in-itch-related-scratching-behaviour-of-imiquimod-induced-psoriasis-like-dermatitis-in-mice
#11
Nobuaki Takahashi, Mitsutoshi Tominaga, Ryohei Kosaka, Yayoi Kamata, Yoshie Umehara, Hironori Matsuda, Azumi Sakaguchi, Hideoki Ogawa, Kenji Takamori
The pathogenesis of psoriatic itch is poorly understood. The aim of this study was to investigate the involvement of opioid receptors in scratching behaviour of imiquimod-induced psoriasis-like dermatitis model mice. Topical application of 5% imiquimod cream to the rostral back skin of mice induced antihistamine-resistant scratching behaviour. The expression of µ-opioid receptor (MOR) protein increased in the epidermis, dorsal root ganglia (DRG) and spinal cord of imiquimod-treated mice. In contrast, the expression of κ-opioid receptor (KOR) protein decreased in the DRG and spinal cord of imiquimod-treated mice, and was undetectable in the epidermis of both groups...
May 17, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28508174/preclinical-comparison-of-mechanistically-different-antiseizure-antinociceptive-and-or-antidepressant-drugs-in-a-battery-of-rodent-models-of-nociceptive-and-neuropathic-pain
#12
Misty D Smith, Jose H Woodhead, Laura J Handy, Timothy H Pruess, Fabiola Vanegas, Erin Grussendorf, Joel Grussendorf, Karen White, Karolina K Bulaj, Reisa K Krumin, Megan Hunt, Karen S Wilcox
The series of experiments herein evaluated prototype drugs representing different mechanisms of antiseizure, antinociceptive or antidepressant action in a battery of preclinical pain models in adult male CF#1 mice (formalin, writhing, and tail flick) and Sprague Dawley rats partial sciatic nerve ligation (PSNL). In the formalin assay, phenytoin (PHT, 6 mg/kg), sodium valproate (VPA, 300 mg/kg), amitriptyline (AMI, 7.5 and 15 mg/kg), gabapentin (GBP, 30 and 70 mg/kg), tiagabine (TGB, 5 and 15 mg/kg), and acetominophen (APAP, 250 and 500 mg/kg) reduced both phases of the formalin response to ≤ 25% of vehicle-treated mice...
May 15, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28503008/a-new-model-order-reduction-strategy-adapted-to-nonlinear-problems-in-earthquake-engineering
#13
Franz Bamer, Abbas Kazemi Amiri, Christian Bucher
Earthquake dynamic response analysis of large complex structures, especially in the presence of nonlinearities, usually turns out to be computationally expensive. In this paper, the methodical developments of a new model order reduction strategy (MOR) based on the proper orthogonal decomposition (POD) method as well as its practical applicability to a realistic building structure are presented. The seismic performance of the building structure, a medical complex, is to be improved by means of base isolation realized by frictional pendulum bearings...
April 10, 2017: Earthquake Engineering & Structural Dynamics
https://www.readbyqxmd.com/read/28501425/the-effects-of-kratom-on-restraint-stress-induced-analgesia-and-its-mechanisms-of-action
#14
José Luis Vázquez López, Lorenz Schild, Thomas Günther, Stefan Schulz, Hartmud Neurath, Axel Becker
ETHNOPHARMACOLOGICAL RELEVANCE: Mitragyna speciosa and its extracts are called kratom (dried leaves, extract). They contain several alkaloids with an affinity for different opioid receptors. They are used in traditional medicine for the treatment of different diseases, as a substitute by opiate addicts, and to mitigate opioid withdrawal symptoms. Apart from their medical properties, they are used to enhance physical endurance and as a means of overcoming stress. PURPOSE: The aim of this study was to determine the mechanisms underlying the effects of kratom on restraint-stress-induced analgesia which occurs during or following exposure to a stressful or fearful stimulus...
May 10, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28493819/the-choice-of-freely-preferred-cadence-by-trained-nonprofessional-cyclists-may-not-be-characterized-by-mechanical-efficiency
#15
Yitzhak Weinstein, Ron Mor-Unikowski, Shachar Nice, Shraga Hocherman, Omri Inbar
BACKGROUND: Most cycling studies involve professional cyclists. Because training may affect riding style, it is of interest to determine the physiological basis for the personal choice of cycling cadence in nonprofessional cyclists. METHODS: Eleven nonprofessional (5.2±1.7-year-riding experience) male road cyclists, aged 35.0±11.0 years, underwent four separate laboratory test sessions. The first two sessions included habituation, anthropometry, V˙O2max,$\dot V{{\text{O}}_{\text{2}}}{\text{max}},$ and lactate threshold (LaTH) measurements...
May 11, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28492502/caregiver-supervision-practices-and-risk-of-childhood-unintentional-injury-mortality-in-bangladesh
#16
Khaula Khatlani, Olakunle Alonge, Aminur Rahman, Dewan Md Emdadul Hoque, Al-Amin Bhuiyan, Priyanka Agrawal, Fazlur Rahman
Unintentional injury-related mortality rate, including drowning among children under five, is disproportionately higher in low- and middle-income countries. The evidence links lapse of supervision with childhood unintentional injury deaths. We determined the relationship between caregiver supervision and unintentional injury mortality among children under five in rural Bangladesh. We conducted a nested, matched, case-control study within the cohort of a large-scale drowning prevention project in Bangladesh, "SOLID-Saving of Children's Lives from Drowning"...
May 11, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28489362/atropisomerism-and-conformational-equilibria-impact-on-pi3k%C3%AE-inhibition-of-2-6-amino-9h-purin-9-yl-methyl-5-methyl-3-o-tolyl-quinazolin-4-3h-one-ic87114-and-its-conformationally-restricted-analogs
#17
Alessio Lodola, Serena Bertolini, Matteo Biagetti, Silvia Capacchi, Fabrizio Facchinetti, Paola Maria Gallo, Alice Pappani, Marco Mor, Daniele Pala, Silvia Rivara, Filippo Visentini, Mauro Corsi, Anna Maria Capelli
IC87114 [compound 1, (2-((6-amino-9H-purin-9-yl)methyl)-5-methyl-3-(o-tolyl)quinazolin-4(3H)-one)] is a potent PI3K inhibitor selective for the δ isoform. As predicted by molecular modeling calculations, rotation around the bond connecting the quinazolin-4(3H)-one nucleus to the o-tolyl is sterically hampered, which leads to separable conformers with axial chirality (i.e., atropisomers). After verifying that the aS and aR isomers of compound 1 do not interconvert in solution, we investigated how biological activity is influenced by axial chirality and conformational equilibrium...
May 15, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28483436/individualized-music-program-is-associated-with-improved-outcomes-for-u-s-nursing-home-residents-with-dementia
#18
Kali S Thomas, Rosa Baier, Cyrus Kosar, Jessica Ogarek, Alissa Trepman, Vincent Mor
OBJECTIVES: The objective of this study was to compare resident outcomes before and after implementation of an individualized music program, MUSIC & MEMORY (M&M), designed to address the behavioral and psychological symptoms associated with dementia (BPSD). SETTING: 98 nursing homes trained in the M&M program during 2013 and 98 matched-pair comparisons. PARTICIPANTS: Long-stay residents with Alzheimer's disease and related dementias (ADRD) residing in M&M participating facilities (N = 12,905) and comparison facilities (N = 12,811) during 2012-2013...
April 14, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28482956/tuberculosis-in-migrants-in-low-incidence-countries-epidemiology-and-intervention-entry-points
#19
K Lönnroth, Z Mor, C Erkens, J Bruchfeld, R R Nathavitharana, M J van der Werf, C Lange
As tuberculosis (TB) rates continue to decline in native populations in most low TB incidence countries, the proportion of TB patients born outside their country of residence ('foreign-born') increases. Some low-incidence countries have experienced a substantial increase in TB rates related to recent increases in the number of asylum seekers and other migrants from TB-endemic countries. However, average TB rates among the foreign-born in low-incidence countries declined moderately in 2009-2015. TB in foreign-born individuals is commonly the result of reactivation of latent infection with Mycobacterium tuberculosis acquired outside the host country...
June 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28481602/a-national-evaluation-of-homeless-and-nonhomeless-veterans-experiences-with-primary-care
#20
Audrey L Jones, Leslie R M Hausmann, Gretchen L Haas, Maria K Mor, John P Cashy, James H Schaefer, Adam J Gordon
Persons who are homeless, particularly those with mental health and/or substance use disorders (MHSUDs), often do not access or receive continuous primary care services. In addition, negative experiences with primary care might contribute to homeless persons' avoidance and early termination of MHSUD treatment. The patient-centered medical home (PCMH) model aims to address care fragmentation and improve patient experiences. How homeless persons with MHSUDs experience care within PCMHs is unknown. This study compared the primary care experiences of homeless and nonhomeless veterans with MHSUDs receiving care in the Veterans Health Administration's medical home environment, called Patient Aligned Care Teams...
May 2017: Psychological Services
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