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https://www.readbyqxmd.com/read/28213494/plc%C3%AE%C2%B51-regulates-sdf-1%C3%AE-induced-lymphocyte-adhesion-and-migration-to-sites-of-inflammation
#1
Marianne Strazza, Inbar Azoulay-Alfaguter, Michael Peled, Alan V Smrcka, Edward Y Skolnik, Shekhar Srivastava, Adam Mor
Regulation of integrins is critical for lymphocyte adhesion to endothelium and migration throughout the body. Inside-out signaling to integrins is mediated by the small GTPase Ras-proximate-1 (Rap1). Using an RNA-mediated interference screen, we identified phospholipase Cε 1 (PLCε1) as a crucial regulator of stromal cell-derived factor 1 alpha (SDF-1α)-induced Rap1 activation. We have shown that SDF-1α-induced activation of Rap1 is transient in comparison with the sustained level following cross-linking of the antigen receptor...
February 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28209408/household-air-pollution-from-various-types-of-rural-kitchens-and-its-exposure-assessment
#2
Maninder Kaur Sidhu, Khaiwal Ravindra, Suman Mor, Siby John
Exposure to household air pollutants has become a leading environmental health risk in developing countries. Considering this, real-time temporal variation in fine particulate matter (PM2.5) and carbon monoxide (CO) concentrations were measured in various types of rural household kitchens. Observed average concentrations of PM2.5, CO, percent relative humidity (%RH) and temperature (T) in five different kitchen types were 549.6μg/m(3), 4.2ppm, 70.2% and 20°C respectively. Highest CO and PM2.5 concentration were found in household performing cooking in indoor kitchens (CO: 9...
February 13, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28204957/insights-into-the-role-of-opioid-receptors-in-the-gi-tract-experimental-evidence-and-therapeutic-relevance
#3
James J Galligan, Catia Sternini
Opioid drugs are prescribed extensively for pain treatment but when used chronically they induce constipation that can progress to opioid-induced bowel dysfunction. Opioid drugs interact with three classes of opioid receptors: mu opioid receptors (MORs), delta opioid receptors (DOR), and kappa opioid receptors (KORs), but opioid drugs mostly target the MORs. Upon stimulation, opioid receptors couple to inhibitory Gi/Go proteins that activate or inhibit downstream effector proteins. MOR and DOR couple to inhibition of adenylate cyclase and voltage-gated Ca(2+) channels and to activation of K(+) channels resulting in reduced neuronal activity and neurotransmitter release...
February 16, 2017: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/28204523/evidence-for-hepatitis-a-virus-endemic-circulation-in-israel-despite-universal-toddler-vaccination-since-1999-and-low-clinical-incidence-in-all-age-groups
#4
Yosef Manor, Matthew Lewis, Daniela Ram, Nili Daudi, Orna Mor, Michal Savion, Zipi Kra-Oz, Yonat Shemer Avni, Rivka Sheffer, Daniel Shouval, Ella Mendelson
No abstract text is available yet for this article.
December 24, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28199982/n-acetyl-cysteine-attenuates-remifentanil-induced-postoperative-hyperalgesia-via-inhibiting-matrix-metalloproteinase-9-in-dorsal-root-ganglia
#5
Yue Liu, Yuan Ni, Wei Zhang, Yu-E Sun, Zhengliang Ma, Xiaoping Gu
Treatment of remifentanil-induced postoperative hyperalgesia (RIH) remains a clinical challenge because the mechanisms are not fully understood. Matrix metalloproteinase-9 (MMP-9) is a key component in neuroinflammation because of its facilitation of pro-inflammatory cytokine maturation. Therefore, inhibition of MMP-9 may represent a novel therapeutic approach to the treatment of RIH. Sprague-Dawley rats were randomly divided into three groups: Control, Incision and Remifentanil. A right plantar surgical incision was performed in Group Incision, and intraoperative remifentanil (0...
February 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28198561/nursing-home-use-after-implantable-cardioverter-defibrillator-implantation-in-older-adults-results-from-the-national-cardiovascular-data-registry
#6
Daniel B Kramer, Matthew R Reynolds, Sharon-Lise Normand, Craig S Parzynski, John A Spertus, Vincent Mor, Susan L Mitchell
OBJECTIVES: To evaluate the incidence and characteristics of nursing home (NH) use after implantable cardioverter-defibrillator (ICD) implantation. DESIGN: Cohort study. SETTING: Medicare beneficiaries in the National Cardiovascular Data Registry-ICD Registry. PARTICIPANTS: Individuals aged 65 and older receiving ICDs between January 1, 2006, and March 31, 2010 (N = 192,483). MEASUREMENTS: Proportion of ICD recipients discharged to NHs directly after device placement, cumulative incidence of long-term NH admission, and factors associated with immediate discharge to a NH and time to long-term NH admission...
February 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28196094/innate-immunity-mediated-longevity-and-longevity-induced-by-germ-cell-removal-converge-on-the-c-type-lectin-domain-protein-irg-7
#7
Elad Yunger, Modi Safra, Mor Levi-Ferber, Anat Haviv-Chesner, Sivan Henis-Korenblit
In C. elegans, removal of the germline triggers molecular events in the neighboring intestine, which sends an anti-aging signal to the rest of the animal. In this study, we identified an innate immunity related gene, named irg-7, as a novel mediator of longevity in germlineless animals. We consider irg-7 to be an integral downstream component of the germline longevity pathway because its expression increases upon germ cell removal and its depletion interferes with the activation of the longevity-promoting transcription factors DAF-16 and DAF-12 in germlineless animals...
February 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28195573/whole-exome-sequencing-of-individuals-from-an-isolated-population-implicates-rare-risk-variants-in-bipolar-disorder
#8
F Lescai, T D Als, Q Li, M Nyegaard, G Andorsdottir, M Biskopstø, A Hedemand, A Fiorentino, N O'Brien, A Jarram, J Liang, J Grove, J Pallesen, E Eickhardt, M Mattheisen, L Bolund, D Demontis, A G Wang, A McQuillin, O Mors, J Wang, A D Børglum
Bipolar disorder affects about 1% of the world's population, and its estimated heritability is about 75%. Only few whole genome or whole-exome sequencing studies in bipolar disorder have been reported, and no rare coding variants have yet been robustly identified. The use of isolated populations might help finding variants with a recent origin, more likely to have drifted to higher frequency by chance. Following this approach, we investigated 28 bipolar cases and 214 controls from the Faroe Islands by whole exome sequencing, and the results were followed-up in a British sample of 2025 cases and 1358 controls...
February 14, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28188737/genetic-variation-in-the-behavioral-effects-of-buprenorphine-in-female-mice-derived-from-a-murine-model-of-the-oprm1-a118g-polymorphism
#9
Caroline A Browne, Rebecca L Erickson, Julie A Blendy, Irwin Lucki
Pharmacogenetic studies have identified the non-synonymous single nucleotide polymorphism (A118G) in the human mu opioid receptor (MOR) gene (OPRM1) as a critical genetic variant capable of altering the efficacy of opioid therapeutics. To date few studies have explored the potential impact of the OPRM1 A118G polymorphism on the pharmacological effects of buprenorphine (BPN), a potent MOR partial agonist and kappa opioid receptor antagonist, which is approved by the FDA for the treatment of opioid addiction and chronic pain...
February 7, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28186940/missed-opportunities-for-earlier-diagnosis-of-hiv-in-patients-who-presented-with-advanced-hiv-disease-a-retrospective-cohort-study
#10
Itzchak Levy, Yasmin Maor, Naim Mahroum, Liraz Olmer, Anat Wieder, Vladislav Litchevski, Orna Mor, Galia Rahav
OBJECTIVE: To quantify and characterise missed opportunities for earlier HIV diagnosis in patients diagnosed with advanced HIV. DESIGN: A retrospective observational cohort study. SETTING: A central tertiary medical centre in Israel. MEASURES: The proportion of patients with advanced HIV, the proportion of missed opportunities to diagnose them earlier, and the rate of clinical indicator diseases (CIDs) in those patients...
November 10, 2016: BMJ Open
https://www.readbyqxmd.com/read/28186217/time-and-space-resolved-study-of-the-methanol-to-hydrocarbons-mth-reaction-influence-of-zeolite-topology-on-axial-deactivation-patterns
#11
Daniel Rojo-Gama, Samaneh Etemadi, Eliot Kirby, Karl Petter Lillerud, Pablo Beato, Stian Svelle, Unni Olsbye
Zeolites representing seven different topologies were subjected to life-time assessment studies as methanol to hydrocarbons (MTH) catalysts at 400 °C, P(MeOH) = 13 kPa and P(tot) = 100 kPa. The following topologies were studied: ZSM-22 (TON), ZSM-23 (MTT), IM-5 (IMF), ITQ-13 (ITH), ZSM-5 (MFI), mordenite (MOR) and beta (BEA). Two experimental approaches were used. In the first approach, each catalyst was tested at three different contact times, all giving 100% initial conversion. The life-time before conversion decreased to 50% at each contact time was measured and used to calculate critical contact times (i...
February 10, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28185645/mu-opioid-receptors-in-gamma-aminobutyric-acidergic-forebrain-neurons-moderate-motivation-for-heroin-and-palatable-food
#12
Pauline Charbogne, Olivier Gardon, Elena Martín-García, Helen L Keyworth, Aya Matsui, Anna E Mechling, Thomas Bienert, Taufiq Nasseef, Anne Robé, Luc Moquin, Emmanuel Darcq, Sami Ben Hamida, Patricia Robledo, Audrey Matifas, Katia Befort, Claire Gavériaux-Ruff, Laura-Adela Harsan, Dominik von Elverfeldt, Jurgen Hennig, Alain Gratton, Ian Kitchen, Alexis Bailey, Veronica A Alvarez, Rafael Maldonado, Brigitte L Kieffer
BACKGROUND: Mu opioid receptors (MORs) are central to pain control, drug reward, and addictive behaviors, but underlying circuit mechanisms have been poorly explored by genetic approaches. Here we investigate the contribution of MORs expressed in gamma-aminobutyric acidergic forebrain neurons to major biological effects of opiates, and also challenge the canonical disinhibition model of opiate reward. METHODS: We used Dlx5/6-mediated recombination to create conditional Oprm1 mice in gamma-aminobutyric acidergic forebrain neurons...
December 26, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/28185312/reproducibility-and-experience-dependence-of-echocardiographic-indices-of-left-ventricular-function-side-by-side-comparison-of-global-longitudinal-strain-and-ejection-fraction
#13
Diego Medvedofsky, Kalie Kebed, Luke Laffin, Jeremy Stone, Karima Addetia, Roberto M Lang, Victor Mor-Avi
BACKGROUND: Although left ventricular (LV) ejection fraction (EF) and global longitudinal strain (GLS) are recommended by the current echocardiographic chamber quantification guidelines, these measurements are not performed routinely. Because EF measurements rely on manual tracing of LV boundaries, and are subject to inter-reader variability and experience dependence, we hypothesized that semiautomated GLS measurements using speckle tracking would be more reproducible and less experience-dependent...
February 9, 2017: Echocardiography
https://www.readbyqxmd.com/read/28179123/spinal-or-supraspinal-phosphorylation-deficiency-at-the-mor-c-terminus-does-not-affect-morphine-tolerance-in-vivo
#14
Cherkaouia Kibaly, Hong-Yiou Lin, Horace H Loh, Ping-Yee Law
The development of tolerance to morphine, one of the most potent analgesics, in the management of chronic pain is a significant clinical problem and its mechanisms are poorly understood. Morphine exerts its pharmacological effects via the μ-opioid receptor (MOR). Tolerance is highly connected to G-protein-coupled receptors (GPCR) phosphorylation and desensitization increase. Because morphine desensitization previously has been shown to be MOR phosphorylation- and ß-arrestin2-independent (in contrast to agonists such as fentanyl), we examined the contribution of phosphorylation of the entire C-terminus to the development of antinociceptive tolerance to the partial (morphine) and full (fentanyl) MOR agonists in vivo...
February 4, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28177195/high-incidence-of-zika-virus-infection-detected-in-plasma-and-cervical-cytology-specimens-from-pregnant-women-in-guayaquil-ecuador
#15
Hector Zambrano, Jesse Waggoner, Karina León, Benjamin Pinsky, Ketty Vera, Marissa Schettino, Lisette Rivera, José Landivar, María Granda, Angela Lee, Gil Mor
Zika virus (ZIKV) infection during pregnancy has been linked to severe birth defects, and the epidemiologic situation of the ZIKV epidemic in Ecuador is poorly understood. Guayaquil, Ecuador, has a tropical climate and experiences frequent outbreaks of dengue and chikungunya virus, and in December 2015, ZIKV was identified. Given the well-documented effects of ZIKV in pregnancy, including microcephaly, we tested for the presence of ZIKV in both plasma and cervical cytology of pregnant women. We report the identification of a population of pregnant women with a high incidence of ZIKV infection detected in the plasma and lower reproductive tract...
February 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28176609/outbreak-of-highly-pathogenic-avian-influenza-in-minnesota-in-2015
#16
Ann Fitzpatrick, Sunil K Mor, Mary Thurn, Elizabeth Wiedenman, Tracy Otterson, Robert E Porter, Devi P Patnayak, Dale C Lauer, Shauna Voss, Stephanie Rossow, James E Collins, Sagar M Goyal
The incursion of highly pathogenic avian influenza (HPAI) into the United States during 2014 resulted in an unprecedented foreign animal disease (FAD) event; 232 outbreaks were reported from 21 states. The disease affected 49.6 million birds and resulted in economic losses of $950 million. Minnesota is the largest turkey-producing state, accounting for 18% of U.S. turkey production. Areas with concentrated numbers of turkeys in Minnesota were the epicenter of the outbreak. The first case was presumptively diagnosed in the last week of February 2015 at the Minnesota Veterinary Diagnostic Laboratory (MVDL) and confirmed as HPAI H5N2 at the National Veterinary Services Laboratories on March 4, 2015...
January 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28166603/electroacupuncture-attenuates-hyperalgesia-in-rats-withdrawn-from-chronic-alcohol-drinking-via-habenular-mu-opioid-receptors
#17
Jing Li, Caihong Fu, Hongwei Liu, Rao Fu, Wanhong Zuo, Seungwoo Kang, Pei Chen, Danielle Gregor, Rose Paulose, Alex Bekker, Jiang-Hong Ye
BACKGROUND: Hyperalgesia or increased sensitivity to pain is often found in alcoholics during alcohol withdrawal and may contribute to relapse drinking. Alternative therapies such as acupuncture and electroacupuncture (EA), through mechanisms involving opioid receptors, may reduce pain and substance dependence and withdrawal syndromes. The lateral habenula (LHb), an epithalamic structure rich in mu opioid receptors (MORs), is a critical target for both drugs of abuse and pain. We previously observed hyperalgesia in rats withdrawn from chronic ethanol (EtOH) drinking and found that EA at the acupoint Zusanli (ST36) reduced EtOH intake...
February 6, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28166237/no-benefits-of-statins-for-sudden-cardiac-death-prevention-in-patients-with-heart-failure-and-reduced-ejection-fraction-a-meta-analysis-of-randomized-controlled-trials
#18
Muaamar Al-Gobari, Hai-Ha Le, Mor Fall, François Gueyffier, Bernard Burnand
BACKGROUND AND OBJECTIVES: Statins showed mixed results in heart failure (HF) patients. The benefits in major HF outcomes, including all-cause mortality and sudden cardiac death (SCD), have always been discordant across systematic reviews and meta-analyses. We intended to systematically identify and appraise the available evidence that evaluated the effectiveness of statins in clinical outcomes for HF patients. DESIGN: Systematic review and meta-analysis. DATA SOURCES: We searched, until April 28, 2016: Medline, Embase, ISI Web of Science and EBM reviews (Cochrane DSR, ACP journal club, DARE, CCTR, CMR, HTA, and NHSEED), checked clinicaltrials...
2017: PloS One
https://www.readbyqxmd.com/read/28165452/dek-targeting-dna-aptamers-as-therapeutics-for-inflammatory-arthritis
#19
Nirit Mor-Vaknin, Anjan Saha, Maureen Legendre, Carmelo Carmona-Rivera, M Asif Amin, Bradley J Rabquer, Marta J Gonzales-Hernandez, Julie Jorns, Smriti Mohan, Srilakshmi Yalavarthi, Dave A Pai, Kristine Angevine, Shelley J Almburg, Jason S Knight, Barbara S Adams, Alisa E Koch, David A Fox, David R Engelke, Mariana J Kaplan, David M Markovitz
Novel therapeutics are required for improving the management of chronic inflammatory diseases. Aptamers are single-stranded RNA or DNA molecules that have recently shown utility in a clinical setting, as they can specifically neutralize biomedically relevant proteins, particularly cell surface and extracellular proteins. The nuclear chromatin protein DEK is a secreted chemoattractant that is abundant in the synovia of patients with juvenile idiopathic arthritis (JIA). Here, we show that DEK is crucial to the development of arthritis in mouse models, thus making it an appropriate target for aptamer-based therapy...
February 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/28162604/-363-strain-specific-polymorphisms-and-their-correlation-to-mor-1k-receptor-function
#20
F Oladosu, S O'Buckley, A Nackley
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
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