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https://www.readbyqxmd.com/read/29165911/defects-and-interfaces-on-ptpb-nanoplates-boost-fuel-cell-electrocatalysis
#1
Yingjun Sun, Yanxia Liang, Mingchuan Luo, Fan Lv, Yingnan Qin, Lei Wang, Chuan Xu, Engang Fu, Shaojun Guo
Nanostructured Pt is the most efficient single-metal catalyst for fuel cell technology. Great efforts have been devoted to optimizing the Pt-based alloy nanocrystals with desired structure, composition, and shape for boosting the electrocatalytic activity. However, these well-known controls still show the limited ability in maximizing the Pt utilization efficiency for achieving more efficient fuel cell catalysis. Herein, a new strategy for maximizing the fuel cell catalysis by controlling/tuning the defects and interfaces of PtPb nanoplates using ion irradiation technique is reported...
November 22, 2017: Small
https://www.readbyqxmd.com/read/29163901/violations-of-l%C3%A3-wenstein-s-rule-in-zeolites
#2
Rachel E Fletcher, Sanliang Ling, Ben Slater
Zeolites, microporous aluminosilicates, are amongst the most widely used catalysts in the petrochemical industry. Zeolite catalytic functionality is influenced by the location of tetrahedral alumina and associated counter-cations in the aluminosilicate framework, yet little is definitively known about the factors that govern the framework aluminium arrangement. It is generally accepted that all zeolites obey Löwenstein's rule of "aluminium avoidance", and that -Al-O-Al- bond formation is forbidden. Here, we describe an unprecedented screening of aluminium distribution in catalytically active zeolite SSZ-13 (CHA) in both its protonated and sodium-containing forms, H-SSZ-13 and Na-SSZ-13, using density functional theory (DFT)...
November 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29160301/new-insights-into-the-pharmacogenomics-of-antidepressant-response-from-the-gendep-and-star-d-studies-rare-variant-analysis-and-high-density-imputation
#3
C Fabbri, K E Tansey, R H Perlis, J Hauser, N Henigsberg, W Maier, O Mors, A Placentino, M Rietschel, D Souery, G Breen, C Curtis, L Sang-Hyuk, S Newhouse, H Patel, M Guipponi, N Perroud, G Bondolfi, M O'Donovan, G Lewis, J M Biernacka, R M Weinshilboum, A Farmer, K J Aitchison, I Craig, P McGuffin, R Uher, C M Lewis
Genome-wide association studies have generally failed to identify polymorphisms associated with antidepressant response. Possible reasons include limited coverage of genetic variants that this study tried to address by exome genotyping and dense imputation. A meta-analysis of Genome-Based Therapeutic Drugs for Depression (GENDEP) and Sequenced Treatment Alternatives to Relieve Depression (STAR*D) studies was performed at the single-nucleotide polymorphism (SNP), gene and pathway levels. Coverage of genetic variants was increased compared with previous studies by adding exome genotypes to previously available genome-wide data and using the Haplotype Reference Consortium panel for imputation...
November 21, 2017: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/29159458/cardiopulmonary-exercise-testing-reflects-improved-exercise-capacity-in-response-to-treatment-in-morquio-a-patients-results-of-a-52-week-pilot-study-of-two-different-doses-of-elosulfase-alfa
#4
Kenneth I Berger, Barbara K Burton, Gregory D Lewis, Mark Tarnopolsky, Paul R Harmatz, John J Mitchell, Nicole Muschol, Simon A Jones, V Reid Sutton, Gregory M Pastores, Heather Lau, Rebecca Sparkes, Adam J Shaywitz
OBJECTIVE: To assess impact of a 52-week elosulfase alfa enzyme replacement therapy (ERT) on exercise capacity in Morquio A patients and analyze cardiorespiratory and metabolic function during exercise to uncover exercise limitations beyond skeletal abnormalities. METHODS: Morquio A patients aged ≥7 years, able to walk >200 m in the 6-minute walk test (6MWT), received elosulfase alfa 2.0 mg/kg/week (N = 15) or 4.0 mg/kg/week (N = 10) for 52 weeks in the randomized, double-blind MOR-008 study ( ClinicalTrials...
November 21, 2017: JIMD Reports
https://www.readbyqxmd.com/read/29156467/-diagnosis-and-therapy-of-iris-lesions
#5
Joel M Mor, Konrad R Koch, Ludwig M Heindl
The most common iris lesions are iris nevi, iris melanomas and iris pigment epithelium cysts. However, there is an abundance of rare differential diagnoses that have to be considered, including other melanocytic and non-melanocytic lesions. Diagnostic tools include the slit lamp examination, gonioscopy, tonometry, transillumination, ultrasound biomicroscopy (UBM), optical coherence tomography, fluorescein angiography and standardized photography-assisted documentation. The timely identification of malignant lesions (i...
November 20, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29153577/2d-and-3d-echocardiography-derived-indices-of-left-ventricular-function-and%C3%A2-shape-relationship-with-mortality
#6
Diego Medvedofsky, Francesco Maffessanti, Lynn Weinert, David M Tehrani, Akhil Narang, Karima Addetia, Anuj Mediratta, Stephanie A Besser, Elad Maor, Amit R Patel, Kirk T Spencer, Victor Mor-Avi, Roberto M Lang
OBJECTIVES: This study hypothesized that left ventricular (LV) ejection fraction (EF) and global longitudinal strain (GLS) derived from 3-dimensional echocardiographic (3DE) images would better predict mortality than those obtained by 2-dimensional echocardiographic (2DE) measurements, and that 3DE-based LV shape analysis may have added prognostic value. BACKGROUND: Previous studies have shown that both LVEF and GLS derived from 2DE images predict mortality. Recently, 3DE measurements of these parameters were found to be more accurate and reproducible because of independence of imaging plane and geometric assumptions...
November 10, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29153573/3-dimensional-echocardiographic-analysis%C3%A2-of-the-tricuspid-annulus-provides%C3%A2-new-insights-into-tricuspid-valve%C3%A2-geometry-and-dynamics
#7
Karima Addetia, Denisa Muraru, Federico Veronesi, Csaba Jenei, Giacomo Cavalli, Stephanie A Besser, Victor Mor-Avi, Roberto M Lang, Luigi P Badano
OBJECTIVES: The authors used transthoracic 3-dimensional transthoracic echocardiography (3DE) to characterize tricuspid annulus (TA) geometry and dynamics in healthy volunteers. BACKGROUND: Accurate sizing of the TA is essential for planning tricuspid annuloplasty and for implantation of new percutaneous tricuspid devices. METHODS: 3DE of the TA from 209 healthy volunteers was analyzed using custom software to measure TA area, perimeter, circularity, and dimensions at end diastole (equals tricuspid valve closure), mid-systole, end systole, and late diastole...
November 10, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29150865/enhanced-mu-opioid-receptor-dependent-opioidergic-modulation-of-striatal-cholinergic-transmission-in-dyt1-dystonia
#8
Giulia Ponterio, Annalisa Tassone, Giuseppe Sciamanna, Valentina Vanni, Maria Meringolo, Massimo Santoro, Nicola Biagio Mercuri, Paola Bonsi, Antonio Pisani
BACKGROUND: Mu opioid receptor activation modulates acetylcholine release in the dorsal striatum, an area deeply involved in motor function, habit formation, and reinforcement learning as well as in the pathophysiology of different movement disorders, such as dystonia. Although the role of opioids in drug reward and addiction is well established, their involvement in motor dysfunction remains largely unexplored. METHODS: We used a multidisciplinary approach to investigate the responses to mu activation in 2 mouse models of DYT1 dystonia (Tor1a(+/Δgag) mice, Tor1a(+/-) torsinA null mice, and their respective wild-types)...
November 18, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29149875/prevalence-of-antibiotic-prescription-in-pediatric-outpatients-in-italy-the-role-of-local-health-districts-and-primary-care-physicians-in-determining-variation-a-multilevel-design-for-healthcare-decision-support
#9
Mirko Di Martino, Adele Lallo, Ursula Kirchmayer, Marina Davoli, Danilo Fusco
BACKGROUND: According to scientific literature, antibacterials are prescribed for common pediatric conditions that do not benefit from antibiotic therapy. The link between antibiotic use and bacterial resistance is well known. Antibiotic overprescribing generates high social costs and severe consequences for children. Our objectives were to analyze antibiotic prescription patterns in pediatric outpatients residing in the Lazio region (Italy), to identify physicians' characteristics associated with increased propensity for prescription, to identify the priority axes for action to improve the rational use of antibiotics...
November 17, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29149605/bias-factor-and-therapeutic-window-correlate-to-predict-safer-opioid-analgesics
#10
Cullen L Schmid, Nicole M Kennedy, Nicolette C Ross, Kimberly M Lovell, Zhizhou Yue, Jenny Morgenweck, Michael D Cameron, Thomas D Bannister, Laura M Bohn
Biased agonism has been proposed as a means to separate desirable and adverse drug responses downstream of G protein-coupled receptor (GPCR) targets. Herein, we describe structural features of a series of mu-opioid-receptor (MOR)-selective agonists that preferentially activate receptors to couple to G proteins or to recruit βarrestin proteins. By comparing relative bias for MOR-mediated signaling in each pathway, we demonstrate a strong correlation between the respiratory suppression/antinociception therapeutic window in a series of compounds spanning a wide range of signaling bias...
November 16, 2017: Cell
https://www.readbyqxmd.com/read/29148050/the-pharmacokinetics-of-morphine-and-codeine-in-human-plasma-and-urine-after-oral-administration-of-qiangli-pipa-syrup
#11
Bin-Bin Guo, Yu-Qiao Zhang, Sheng-Feng Wang, Jin-Song Ding, Wen-Hu Zhou
Papaveris pericarpium, a natural source of morphine and codeine, is the principal active component in many antitussive traditional Chinese medicines. We herein report the first PK study of papaveris pericarpium in human plasma and urine following oral administration of single (15, 30, 60 mL) and multiple dose (15 mL) of Qiangli Pipa Syrup (MOR 0.1 mg/mL, COD 0.028 mg/mL) by monitoring morphine and codeine using a HPLC-MS/MS method. Their Tmax and t1/2 values are independent of dosages, while the AUC0-t linearly increased with higher dosages, indicating linear PK characteristics...
November 17, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29144987/benzo-a-pyren-7-8-dihydrodiol-9-10-epoxide-induces-human-trophoblast-swan-71-cell-dysfunctions-due-to-cell-apoptosis-through-disorder-of-mitochondrial-fission-fusion
#12
Weiping Wang, Rong Wang, Qiao Zhang, Gil Mor, Huidong Zhang
Benzo(a)pyren-7,8-dihydrodiol-9,10-epoxide (BPDE) is an endocrine disrupter and ultimate carcinogenic product of benzo(a)pyrene (BaP). Numerous studies have shown that BPDE causes trophoblast-related diseases, such as preeclampsia, growth restriction or miscarriages. However, the underlying mechanism, especially the mitochondria-related BPDE-induced trophoblast dysfunction remains unknown. In this study, we examined mitochondrial functions in BPDE-induced human trophoblast cell line Swan 71. BPDE decreased cell ability, attenuated cell invasion and HCG secretion, induced cell apoptosis, decreased mitochondrial membrane potential, increased reactive oxygen species (ROS) and MDA, and decreased SOD activity in a dose-dependent manner...
November 13, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29143042/synthesis-and-characterization-of-the-first-inhibitor-of-n-acylphosphatidylethanolamine-phospholipase-d-nape-pld
#13
Beatrice Castellani, Eleonora Diamanti, Daniela Pizzirani, Piero Tardia, Martina Maccesi, Natalia Realini, Paola Magotti, Gianpiero Garau, Thomas Bakkum, Silvia Rivara, Marco Mor, Daniele Piomelli
N-Acylphosphatidylethanolamine phospholipase D (NAPE-PLD) is a membrane-associated zinc enzyme that catalyzes the hydrolysis of N-acylphosphatidylethanolamines (NAPEs) into fatty acid ethanolamides (FAEs). Here, we describe the identification of the first small-molecule NAPE-PLD inhibitor, the quinazoline sulfonamide derivative 2,4-dioxo-N-[4-(4-pyridyl)phenyl]-1H-quinazoline-6-sulfonamide, ARN19874.
November 16, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29141032/a-qualitative-exploration-of-malaria-operational-research-situation-in-nigeria
#14
IkeOluwapo O Ajayi, Maduka D Ughasoro, Akintayo Ogunwale, Oluwaseun Odeyinka, Obafemi Babalola, Salami Sharafadeen, Al-Mukhtar Y Adamu, Olufemi Ajumobi, Taiwo Orimogunje, Patrick Nguku
BACKGROUND: Malaria, remains one of the leading causes of high morbidity and mortality in Nigeria despite implementation of several public health interventions for its control. Operational limitations and methodological gaps have been associated with malaria control interventions and research, and these have necessitated the need for a well-tailored Malaria Operational Research (MOR) agenda. However, there is paucity of evidence-based information on relevant stakeholders' experience, awareness, perceptions and use of MOR and suggestions on setting MOR agenda...
2017: PloS One
https://www.readbyqxmd.com/read/29138466/manganese-availability-is-negatively-associated-with-carbon-storage-in-northern-coniferous-forest-humus-layers
#15
Johan Stendahl, Björn Berg, Björn D Lindahl
Carbon sequestration below ground depends on organic matter input and decomposition, but regulatory bottlenecks remain unclear. The relative importance of plant production, climate and edaphic factors has to be elucidated to better predict carbon storage in forests. In Swedish forest soil inventory data from across the entire boreal latitudinal range (n = 2378), the concentration of exchangeable manganese was singled out as the strongest predictor (R(2) = 0.26) of carbon storage in the extensive organic horizon (mor layer), which accounts for one third of the total below ground carbon...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29132133/endomorphins-promising-endogenous-opioid-peptides-for-the-development-of-novel-analgesics
#16
Zheng-Hui Gu, Bo Wang, Zhen-Zhen Kou, Yang Bai, Tao Chen, Yu-Lin Dong, Hui Li, Yun-Qing Li
Endomorphin-1 (EM1) and endomorphin-2 (EM2) are two endogenous ligands that belong to the opioid peptide family and have the highest affinity and selectivity for the µ-opioid receptor (MOR). The neuroanatomical distribution, ultrastructural features and neural circuitry of EM-containing neuronal structures have been morphologically demonstrated. In addition, the modulation effects of the EMs in different areas reflect their potential endogenous roles in many major physiological processes, including their remarkable roles in the transmission and modulation of noxious information...
November 13, 2017: Neuro-Signals
https://www.readbyqxmd.com/read/29131259/microrna-21-functions-as-an-oncogene-and-promotes-cell-proliferation-and-invasion-via-timp3-in-renal-cancer
#17
J Chen, Y Gu, W Shen
OBJECTIVE: Renal cell carcinoma (RCC) displays an increasing incidence and mortality rate worldwide in recent years. More and more evidence identified microRNAs function as positive or negative regulatory factors in many cancers, but the role of miR-21 in RCC remains unclear. PATIENTS AND METHODS: Relative expression levels of miR-21 in human RCC tissue samples and RCC-derived cell lines were measured using quantitative real-time Polymerase Chain Reaction (PCR)...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29129606/transgenerational-blunting-of-morphine-induced-corticosterone-secretion-is-associated-with-dysregulated-gene-expression-in-male-offspring
#18
Fair M Vassoler, Anika M Toorie, Elizabeth M Byrnes
A number of parental experiences, even when occurring prior to conception, have been shown to induce transgenerational effects beyond the first generation. In the case of exposure to drugs of abuse, studies in rodents suggest that offspring demonstrate significant differences in how they respond to the drug to which their parent was exposed. We have previously observed significant alterations in morphine analgesia, conditioned place preference and self-administration in the offspring of females exposed to morphine during adolescent development...
November 9, 2017: Brain Research
https://www.readbyqxmd.com/read/29126858/age-sex-and-dose-effects-of-nonbenzodiazepine-hypnotics-on-hip-fracture-in-nursing-home-residents
#19
David D Dore, Andrew R Zullo, Vincent Mor, Yoojin Lee, Sarah D Berry
OBJECTIVE: The Food and Drug Administration recommends a reduced dose of nonbenzodiazepine hypnotics in women, yet little is known about the age-, sex-, and dose-specific effects of these drugs on risk of hip fracture, especially among nursing home (NH) residents. We estimated the age-, sex-, and dose-specific effects of nonbenzodiazepine hypnotics on the rate of hip fracture among NH residents. DESIGN AND SETTING: Case-crossover study in US NHs. PARTICIPANTS: A total of 691 women and 179 men with hip fracture sampled from all US long-stay NH residents...
November 7, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29118464/eocene-squalomorph-sharks-chondrichthyes-elasmobranchii-from-antarctica
#20
Andrea Engelbrecht, Thomas Mörs, Marcelo A Reguero, Jürgen Kriwet
Rare remains of predominantly deep-water sharks of the families Hexanchidae, Squalidae, Dalatiidae, Centrophoridae, and Squatinidae are described from the Eocene La Meseta Formation, Seymour Island, Antarctic Peninsula, which has yielded the most abundant chondrichthyan assemblage from the Southern Hemisphere to date. Previously described representatives of Hexanchus sp., Squalus weltoni, Squalus woodburnei, Centrophorus sp., and Squatina sp. are confirmed and dental variations are documented. Although the teeth of Squatina sp...
October 2017: Journal of South American Earth Sciences
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