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https://www.readbyqxmd.com/read/28636287/the-spectrum-of-aseptic-central-nervous-system-infections-in-southern-germany-demographic-clinical-and-laboratory-findings
#1
M Kaminski, V Grummel, D Hoffmann, A Berthele, B Hemmer
BACKGROUND AND PURPOSE: Aseptic infections of the central nervous system (CNS) are frequently observed in Germany. However, no study has systematically addressed the spectrum of aseptic CNS infections in Germany. METHODS: Data on 191 adult patients diagnosed from January 2007 to December 2014 with aseptic meningitis or encephalitis/meningoencephalitis at our hospital were collected by chart review and analyzed for demographic, clinical and laboratory findings. Patients were stratified according to the causative virus and findings were compared between groups...
June 21, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28635667/a-review-of-flaviviruses-that-have-no-known-arthropod-vector
#2
REVIEW
Bradley J Blitvich, Andrew E Firth
Most viruses in the genus Flavivirus are horizontally transmitted between hematophagous arthropods and vertebrate hosts, but some are maintained in arthropod- or vertebrate-restricted transmission cycles. Flaviviruses maintained by vertebrate-only transmission are commonly referred to as no known vector (NKV) flaviviruses. Fourteen species and two subtypes of NKV flaviviruses are recognized by the International Committee on Taxonomy of Viruses (ICTV), and Tamana bat virus potentially belongs to this group. NKV flaviviruses have been isolated in nature almost exclusively from bats and rodents; exceptions are the two isolates of Dakar bat virus recovered from febrile humans and the recent isolations of Sokoluk virus from field-collected ticks, which raises questions as to whether it should remain classified as an NKV flavivirus...
June 21, 2017: Viruses
https://www.readbyqxmd.com/read/28634573/tick-bioactive-molecules-as-novel-therapeutics-beyond-vaccine-targets
#3
Kristen E Murfin, Erol Fikrig
No abstract text is available yet for this article.
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28634526/concurrent-babesiosis-and-serological-evidence-of-lyme-disease-in-a-young-patient
#4
Mark Adler, Thein Swe, Akari Thein Naing
Human babesiosis co-infected with Lyme disease in a young patient is an important condition. Here, we describe a case of a 39-year-old male patient with concurrent babesiosis and Lyme disease. Co-infections of tick borne diseases are often difficult to diagnose and underreported, and resulting in significant morbidity and mortality to patients. While co-infections have been infrequently described, it is of paramount importance that clinicians should be able to diagnose early and treat them effectively according to the patient geographical area and history of tick bite...
January 2017: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/28633503/range-expansion-and-increasing-borrelia-burgdorferi-infection-of-the-tick-ixodes-scapularis-acari-ixodidae-in-iowa-1990-2013
#5
Jonathan D Oliver, Steve W Bennett, Lorenza Beati, Lyric C Bartholomay
A passive surveillance program monitored ticks submitted by the public in Iowa from 1990-2013. Submitted ticks were identified to species and life stage, and Ixodes scapularis Say nymphs and adults were tested for the presence of Borrelia burgdorferi. An average of 2.6 of Iowa's 99 counties submitted first reports of I. scapularis per year over the surveillance period, indicating expansion of this tick species across the state. The proportion of vector ticks infected by B. burgdorferi increased over time between 1998 and 2013...
June 17, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28632298/patient-med-tbe-f%C3%A3-rb%C3%A3-ttrades-snabbt-vid-behandling-med-kortison-evidens-saknas-dock-f%C3%A3-r-v%C3%A3-rdet-av-immunmodulerande-terapi
#6
Carl Wengse, Jesper Ericsson, Susanna Hallberg, Johan Ursing
Rapid improvement of tick-borne encephalitis after treatment with corticosteroids Tick-borne encephalitis (TBE) is a viral disease transmitted by ticks. The virus is divided into three subtypes named Western, Siberian and Far Eastern TBE virus (TBEV). Western TBEV is endemic in parts of Europe and Sweden and typically causes a biphasic illness with influenza-like symptoms followed by neurological symptoms ranging from mild meningitis to severe meningoencephalitis and death. Despite an effective vaccine, TBE is increasing in Sweden and Europe...
June 16, 2017: Läkartidningen
https://www.readbyqxmd.com/read/28631423/pet-ownership-increases-human-risk-of-encountering-ticks
#7
E H Jones, A F Hinckley, S A Hook, J I Meek, B Backenson, K J Kugeler, K A Feldman
We examined whether pet ownership increased the risk for tick encounters and tickborne disease among residents of three Lyme disease-endemic states as a nested cohort within a randomized controlled trial. Information about pet ownership, use of tick control for pets, property characteristics, tick encounters and human tickborne disease were captured through surveys, and associations were assessed using univariate and multivariable analyses. Pet-owning households had 1.83 times the risk (95% CI = 1.53, 2.20) of finding ticks crawling on and 1...
June 19, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/28631117/multi-criteria-decision-analysis-to-model-ixodes-ricinus-habitat-suitability
#8
Raphaël Rousseau, Guy McGrath, Barry J McMahon, Sophie O Vanwambeke
Tick-borne diseases present a major threat to both human and livestock health throughout Europe. The risk of infection is directly related to the presence of its vector. Thereby it is important to know their distribution, which is strongly associated with environmental factors: the presence and availability of a suitable habitat, of a suitable climate and of hosts. The present study models the habitat suitability for Ixodes ricinus in Ireland, where data on tick distribution are scarce. Tick habitat suitability was estimated at a coarse scale (10 km) with a multi-criteria decision analysis (MCDA) method according to four different scenarios (depending on the variables used and on the weights granted to each of them)...
June 19, 2017: EcoHealth
https://www.readbyqxmd.com/read/28631054/adaptation-of-tick-borne-encephalitis-virus-from-human-brain-to-different-cell-cultures-induces-multiple-genomic-substitutions
#9
Eugenia P Ponomareva, Vladimir A Ternovoi, Tamara P Mikryukova, Elena V Protopopova, Anastasia V Gladysheva, Alexander N Shvalov, Svetlana N Konovalova, Eugene V Chausov, Valery B Loktev
The C11-13 strain from the Siberian subtype of tick-borne encephalitis virus (TBEV) was isolated from human brain using pig embryo kidney (PEK), 293, and Neuro-2a cells. Analysis of the complete viral genome of the C11-13 variants during six passages in these cells revealed that the cell-adapted C11-13 variants had multiple amino acid substitutions as compared to TBEV from human brain. Seven out of eight amino acids substitutions in the high-replicating C11-13(PEK) variant mapped to non-structural proteins; 13 out of 14 substitutions in the well-replicating C11-13(293) variant, and all four substitutions in the low-replicating C11-13(Neuro-2a) variant were also localized in non-structural proteins, predominantly in the NS2a (2), NS3 (6) and NS5 (3) proteins...
June 19, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28630025/the-clock-is-ticking-ageing-of-the-circadian-system-from-physiology-to-cell-cycle
#10
REVIEW
Eva Terzibasi-Tozzini, Antonio Martinez-Nicolas, Alejandro Lucas-Sánchez
The circadian system is the responsible to organise the internal temporal order in relation to the environment of every process of the organisms producing the circadian rhythms. These rhythms have a fixed phase relationship among them and with the environment in order to optimise the available energy and resources. From a cellular level, circadian rhythms are controlled by genetic positive and negative auto-regulated transcriptional and translational feedback loops, which generate 24hour rhythms in mRNA and protein levels of the clock components...
June 16, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28630001/host-influence-in-the-genomic-composition-of-flaviviruses-a-multivariate-approach
#11
Diego Simón, Alvaro Fajardo, Martín Sóñora, Adriana Delfraro, Héctor Musto
Flaviviruses present substantial differences in their host range and transmissibility. We studied the evolution of base composition, dinucleotide biases, codon usage and amino acid frequencies in the genus Flavivirus within a phylogenetic framework by principal components analysis. There is a mutual interplay between the evolutionary history of flaviviruses and their respective vectors and/or hosts. Hosts associated to distinct phylogenetic groups may be driving flaviviruses at different pace and through various sequence landscapes, as can be seen for viruses associated with Aedes or Culex spp...
June 16, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28628633/pro-inflammatory-immune-responses-are-associated-with-clinical-signs-and-symptoms-of-human-anaplasmosis
#12
Anna M Schotthoefer, Steven J Schrodi, Jennifer K Meece, Thomas R Fritsche, Sanjay K Shukla
Human anaplasmosis (HA) is an emerging tick-borne disease that may present as a mild flu-like illness or a life threatening, sepsis-like condition. Although disease severity is hypothesized to relate to immunopathology and immune dysfunction in humans, studies to directly measure immune responses in infected humans have been very limited. We quantified cytokines in 80 confirmed HA patients using a multiplex chemiluminescence immunoassay system and compared similarly measured responses in 1000 control subjects...
2017: PloS One
https://www.readbyqxmd.com/read/28628458/rickettsia-sibirica-mongolitimonae-infection-turkey-2016
#13
Ferit Kuscu, Omer Orkun, Aslihan Ulu, Behice Kurtaran, Suheyla Komur, A Seza Inal, Damla Erdogan, Yesim Tasova, Hasan S Z Aksu
In 2016, Rickettsia sibirica mongolitimonae was diagnosed for a man in Turkey. He had been bitten by a Hyalomma marginatum tick, from which PCR detected rickettsial DNA. Sequence analysis of the DNA identified R. sibirica mongolitimonae. Immunofluorescence assay of patient serum indicated R. conorii, which cross-reacts. PCR is recommended for rickettsiosis diagnoses.
July 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28625763/effects-of-tectonics-and-large-scale-climatic-changes-on-the-evolutionary-history-of-hyalomma-ticks
#14
Arthur F Sands, Dmitry A Apanaskevich, Sonja Matthee, Ivan G Horak, Alan Harrison, Shahid Karim, Mohammad K Mohammad, Kosta Y Mumcuoglu, Rupika S Rajakaruna, Maria M Santos-Silva, Conrad A Matthee
HyalommaKoch, 1844 are ixodid ticks that infest mammals, birds and reptiles, to which 27 recognized species occur across the Afrotropical, Palearctic and Oriental regions. Despite their medical and veterinary importance, the evolutionary history of the group is enigmatic. To investigate various taxonomic hypotheses based on morphology, and also some of the mechanisms involved in the diversification of the genus, we sequenced and analysed data derived from two mtDNA fragments, three nuclear DNA genes and 47 morphological characters...
June 15, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28625666/a-comparative-analysis-on-the-physicochemical-properties-of-tick-borne-encephalitis-virus-envelope-protein-residues-that-affect-its-antigenic-properties
#15
Yu S Bukin, Yu P Dzhioev, S E Tkachev, I V Kozlova, A I Paramonov, D Ruzek, Z Qu, V I Zlobin
This work is dedicated to the study of the variability of the main antigenic envelope protein E among different strains of tick-borne encephalitis virus at the level of physical and chemical properties of the amino acid residues. E protein variants were extracted from then NCBI database. Four amino acid residues properties in the polypeptide sequences were investigated: the average volume of the amino acid residue in the protein tertiary structure, the number of amino acid residue hydrogen bond donors, the charge of amino acid residue lateral radical and the dipole moment of the amino acid residue...
June 15, 2017: Virus Research
https://www.readbyqxmd.com/read/28623811/residential-exposure-to-pesticides-as-risk-factor-for-childhood-and-young-adult-brain-tumors-a-systematic-review-and-meta-analysis
#16
REVIEW
Geneviève Van Maele-Fabry, Laurence Gamet-Payrastre, Dominique Lison
BACKGROUND: Accumulating evidence suggests a positive association between exposure to non-agricultural pesticides and childhood brain tumors (CBT). OBJECTIVE: (1) To conduct a systematic review and meta-analysis of published studies on the association between residential/household/domestic exposure to pesticides and childhood brain tumors. (2) To clarify variables that could impact the results. METHODS: Publications in English were identified from a MEDLINE search through 28 February 2017 and from the reference list of identified publications...
June 14, 2017: Environment International
https://www.readbyqxmd.com/read/28622856/survey-for-selected-pathogens-in-wild-pigs-sus-scrofa-from-guam-marianna-islands-usa
#17
Christopher A Cleveland, Anthony DeNicola, J P Dubey, Dolores E Hill, Roy D Berghaus, Michael J Yabsley
Pigs (Sus scrofa) were introduced to Guam in the 1600's and are now present in high densities throughout the island. Wild pigs are reservoirs for pathogens of concern to domestic animals and humans. Exposure to porcine parvovirus, transmissible gastroenteritis, and Leptospira interrogans has been documented in domestic swine but data from wild pigs are lacking. The close proximity of humans, domestic animals, and wild pigs, combined with the liberal hunting of wild pigs, results in frequent opportunities for pathogen transmission...
June 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28620610/molecular-detection-of-tick-borne-pathogen-diversities-in-ticks-from-livestock-and-reptiles-along-the-shores-and-adjacent-islands-of-lake-victoria-and-lake-baringo-kenya
#18
David Omondi, Daniel K Masiga, Burtram C Fielding, Edward Kariuki, Yvonne Ukamaka Ajamma, Micky M Mwamuye, Daniel O Ouso, Jandouwe Villinger
Although diverse tick-borne pathogens (TBPs) are endemic to East Africa, with recognized impact on human and livestock health, their diversity and specific interactions with tick and vertebrate host species remain poorly understood in the region. In particular, the role of reptiles in TBP epidemiology remains unknown, despite having been implicated with TBPs of livestock among exported tortoises and lizards. Understanding TBP ecologies, and the potential role of common reptiles, is critical for the development of targeted transmission control strategies for these neglected tropical disease agents...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28620590/functional-redundancy-and-ecological-innovation-shape-the-circulation-of-tick-transmitted-pathogens
#19
Agustín Estrada-Peña, José de la Fuente, Alejandro Cabezas-Cruz
Ticks are vectors of pathogens affecting human and animal health worldwide. Nevertheless, the ecological and evolutionary interactions between ticks, hosts, and pathogens are largely unknown. Here, we integrated a framework to evaluate the associations of the tick Ixodes ricinus with its hosts and environmental niches that impact pathogen circulation. The analysis of tick-hosts association suggested that mammals and lizards were the ancestral hosts of this tick species, and that a leap to Aves occurred around 120 M years ago...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28620587/a-dual-luciferase-reporter-system-for-b-burgdorferi-measures-transcriptional-activity-during-tick-pathogen-interactions
#20
Philip P Adams, Carlos Flores Avile, Mollie W Jewett
Knowledge of the transcriptional responses of vector-borne pathogens at the vector-pathogen interface is critical for understanding disease transmission. Borrelia (Borreliella) burgdorferi, the causative agent of Lyme disease in the United States, is transmitted by the bite of infected Ixodes sp. ticks. It is known that B. burgdorferi has altered patterns of gene expression during tick acquisition, persistence and transmission. Recently, we and others have discovered in vitro expression of RNAs found internal, overlapping, and antisense to annotated open reading frames in the B...
2017: Frontiers in Cellular and Infection Microbiology
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