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https://www.readbyqxmd.com/read/28231302/bioinformatic-prediction-of-g-protein-coupled-receptor-encoding-sequences-from-the-transcriptome-of-the-foreleg-including-the-haller-s-organ-of-the-cattle-tick-rhipicephalus-australis
#1
Sergio Munoz, Felix D Guerrero, Anastasia Kellogg, Andrew M Heekin, Ming-Ying Leung
The cattle tick of Australia, Rhipicephalus australis, is a vector for microbial parasites that cause serious bovine diseases. The Haller's organ, located in the tick's forelegs, is crucial for host detection and mating. To facilitate the development of new technologies for better control of this agricultural pest, we aimed to sequence and annotate the transcriptome of the R. australis forelegs and associated tissues, including the Haller's organ. As G protein-coupled receptors (GPCRs) are an important family of eukaryotic proteins studied as pharmaceutical targets in humans, we prioritized the identification and classification of the GPCRs expressed in the foreleg tissues...
2017: PloS One
https://www.readbyqxmd.com/read/28229397/emerging-causes-of-arbovirus-encephalitis-in-north-america-powassan-chikungunya-and-zika-viruses
#2
REVIEW
Christopher T Doughty, Sigal Yawetz, Jennifer Lyons
Arboviruses are arthropod-borne viruses transmitted by the bite of mosquitoes, ticks, or other arthropods. Arboviruses are a common and an increasing cause of human illness in North America. Powassan virus, Chikungunya virus, and Zika virus are arboviruses that have all recently emerged as increasing causes of neurologic illness. Powassan virus almost exclusively causes encephalitis, but cases are rare, sporadic, and restricted to portions of North America and Russia. Chikungunya virus has spread widely across the world, causing millions of infections...
February 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28229048/anaplasma-phagocytophilum-infection-subverts-carbohydrate-metabolic-pathways-in-the-tick-vector-ixodes-scapularis
#3
Alejandro Cabezas-Cruz, Pilar Alberdi, James J Valdés, Margarita Villar, José de la Fuente
The obligate intracellular pathogen, Anaplasma phagocytophilum, is the causative agent of human, equine, and canine granulocytic anaplasmosis and tick-borne fever (TBF) in ruminants. A. phagocytophilum has become an emerging tick-borne pathogen in the United States, Europe, Africa, and Asia, with increasing numbers of infected people and animals every year. It has been recognized that intracellular pathogens manipulate host cell metabolic pathways to increase infection and transmission in both vertebrate and invertebrate hosts...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28225856/immunogenic-potential-of-rhipicephalus-boophilus-microplus-aquaporin-1-against-rhipicephalus-sanguineus-in-domestic-dogs
#4
Patricia Martinez Évora, Gustavo Seron Sanches, Felix David Guerrero, Adalberto Pérez de León, Gervásio Henrique Bechara
This study evaluated a recombinant aquaporin 1 protein of Rhipicephalus (Boophilus) microplus (RmAQP1) as antigen in a vaccine against R. sanguineus. Five dogs were immunized with RmAQP1 (10 µg) + adjuvant (Montanide) (G1), and five were inoculated with adjuvant only (G2), three times. Twenty-one days after the last immunization, animals of both groups were challenged with R. sanguineus larvae, nymphs and adults, and their biotic potential was compared. Blood samples were collected before each immunization and every 28 days after the last immunization for 10 weeks...
February 16, 2017: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
https://www.readbyqxmd.com/read/28224342/galactose-%C3%AE-1-3-galactose-atypical-food-allergen-or-model-ige-hypersensitivity
#5
REVIEW
Jeffrey M Wilson, Alexander J Schuyler, Nikhila Schroeder, Thomas A E Platts-Mills
PURPOSE OF REVIEW: Galactose-α-1,3-galactose (α-gal) is a carbohydrate allergen with several unique characteristics. In this article, we discuss some recent advances in our understanding of the 'alpha-gal syndrome,' highlight data supporting the role of ticks in pathogenesis, and speculate on immune mechanisms that lead to sensitization. RECENT FINDINGS: First described as the target of IgE in individuals suffering immediate hypersensitivity reactions to the novel anti-EGF monoclonal antibody cetuximab, it is now clear that α-gal sensitization is associated with mammalian meat allergy as well as reactions to other mammalian products...
January 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28223442/periodic-lateral-root-priming-what-makes-it-tick
#6
Kirsten Hendrika Ten Tusscher, Marta Laskowski
Conditioning small groups of root pericycle cells for future lateral root formation has a major impact on overall plant root architecture. This priming of lateral roots occurs rhythmically, involving temporal oscillations in auxin response in the root tip. During growth, this process generates a spatial pattern of prebranch sites, an early stage in lateral root formation characterized by a stably maintained high auxin response. Thusfar, the molecular mechanism behind this rhythmicity has remained elusive. Some data implicate a cell-autonomous oscillation in gene expression, while others strongly support the importance of tissue-level modulations in auxin fluxes...
February 21, 2017: Plant Cell
https://www.readbyqxmd.com/read/28222813/comparative-speed-of-kill-of-sarolaner-simparica-%C3%A2-and-afoxolaner-nexgard-%C3%A2-against-induced-infestations-of-ixodes-holocyclus-on-dogs
#7
Raj Packianathan, Andrew Hodge, Natalie Bruellke, Kylie Davis, Steven Maeder
BACKGROUND: The Australian paralysis tick, Ixodes holocyclus, causes paralysis predominantly in dogs and cats in the Eastern coastal regions of Australia. Rapid onset of effect of a parasiticide is critical to minimize the deleterious effects of these tick infestations, especially tick paralysis caused by the salivary neurotoxin. The speed of kill of a novel orally administered isoxazoline parasiticide, sarolaner chewable tablets (Simparica(®)), against I. holocyclus on dogs was evaluated and compared with afoxolaner (NexGard(®)) for 5 weeks after a single oral dose...
February 21, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28221107/use-of-mass-participation-outdoor-events-to-assess-human-exposure-to-tickborne-pathogens
#8
Jessica L Hall, Kathrin Alpers, Kevin J Bown, Stephen J Martin, Richard J Birtles
Mapping the public health threat of tickborne pathogens requires quantification of not only the density of infected host-seeking ticks but also the rate of human exposure to these ticks. To efficiently sample a high number of persons in a short time, we used a mass-participation outdoor event. In June 2014, we sampled ≈500 persons competing in a 2-day mountain marathon run across predominantly tick-infested habitat in Scotland. From the number of tick bites recorded and prevalence of tick infection with Borrelia burgdoferi sensu lato and B...
March 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28221100/intracellular-degradation-and-localization-of-ns1-of-tick-borne-encephalitis-virus-affect-its-protective-properties
#9
Yulia V Kuzmenko, Elizaveta S Starodubova, Anastasia S Shevtsova, Liubov L Chernokhaeva, Anastasia A Latanova, Olga V Preobrazhenskaia, Andrey V Timofeev, Galina G Karganova, Vadim L Karpov
Currently, many DNA vaccines against infectious diseases are in clinical trials; however, their efficacy needs to be improved. The potency of DNA immunogen can be optimized by targeting technologies. In the current study, to increase the efficacy of NS1 encoded by plasmid, proteasome targeting was applied. NS1 variants with or without translocation sequence and with ornithine decarboxylase as a signal of proteasomal degradation were tested for expression, localization, protein turnover, proteasomal degradation and protection properties...
January 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28220327/genetic-characterization-of-cacipacor%C3%A3-virus-from-ticks-collected-in-s%C3%A3-o-paulo-state-brazil
#10
Glauciane Garcia de Figueiredo, Alberto Anastacio Amarilla, William Marciel de Souza, Marcílio Jorge Fumagalli, Mário Luis Garcia de Figueiredo, Matias Pablo Juan Szabó, Soraya Jabur Badra, Yin Xiang Setoh, Alexander A Khromykh, Victor Hugo Aquino, Luiz Tadeu Moraes Figueiredo
Cacipacoré virus (CPCV) is a potential emerging virus classified in the genus Flavivirus, family Flaviviridae. In the present study, we present the genetic characterization of a CPCV isolated from ticks (Amblyomma cajennense) collected from a sick capybara (Hydrochoerus hydrochaeris) in São Paulo State, Brazil. The CPCV isolate shares the typical genomic organization of flaviviruses with 10,857 nucleotides in length and a single open reading frame of 10,284 nucleotides encoding a polyprotein of 3,427 amino acids...
February 20, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28219390/the-genome-landscape-of-indigenous-african-cattle
#11
Jaemin Kim, Olivier Hanotte, Okeyo Ally Mwai, Tadelle Dessie, Salim Bashir, Boubacar Diallo, Morris Agaba, Kwondo Kim, Woori Kwak, Samsun Sung, Minseok Seo, Hyeonsoo Jeong, Taehyung Kwon, Mengistie Taye, Ki-Duk Song, Dajeong Lim, Seoae Cho, Hyun-Jeong Lee, Duhak Yoon, Sung Jong Oh, Stephen Kemp, Hak-Kyo Lee, Heebal Kim
BACKGROUND: The history of African indigenous cattle and their adaptation to environmental and human selection pressure is at the root of their remarkable diversity. Characterization of this diversity is an essential step towards understanding the genomic basis of productivity and adaptation to survival under African farming systems. RESULTS: We analyze patterns of African cattle genetic variation by sequencing 48 genomes from five indigenous populations and comparing them to the genomes of 53 commercial taurine breeds...
February 20, 2017: Genome Biology
https://www.readbyqxmd.com/read/28218163/preliminary-risk-maps-for-transmission-of-kyasanur-forest-disease-in-southern-india
#12
A Townsend Peterson, Gautam Talukdar
Kyasanur forest disease is known to be transmitted across forested regions of Southern India. The disease appears to be hosted in wild mammals and transmitted by tick vectors although the diversity and identity of host and vector species remain unclear. The area across which risk exists of contracting the disease through transfer from the hosts or vectors, however, has never been mapped in detail, such that the area that surveillance, education, and investment in diagnostic facilities should cover remains unknown...
January 2017: Indian Journal of Public Health
https://www.readbyqxmd.com/read/28216718/indian-tick-typhus-presenting-as-purpura-fulminans-with-review-on-rickettsial-infections
#13
REVIEW
Manjunath Hulmani, P Alekya, V Jagannath Kumar
Rickettsial diseases are some of the most covert reemerging infections of the present times. They are generally incapacitating and notoriously difficult to diagnose; untreated cases can have fatality rates as high as 30%-35%, but when diagnosed properly, they are often easily treated but lack of definite diagnostic tools and the hazards of handling these microorganisms aggravate the difficulties of diagnosis and treatment.
January 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28216658/timing-the-day-what-makes-bacterial-clocks-tick
#14
REVIEW
Carl Hirschie Johnson, Chi Zhao, Yao Xu, Tetsuya Mori
Chronobiological studies of prokaryotic organisms have generally lagged far behind the study of endogenous circadian clocks in eukaryotes, in which such systems are essentially ubiquitous. However, despite only being studied during the past 25 years, cyanobacteria have become important model organisms for the study of circadian rhythms and, presently, their timekeeping mechanism is the best understood of any system in terms of biochemistry, structural biology, biophysics and adaptive importance. Nevertheless, intrinsic daily rhythmicity among bacteria other than cyanobacteria is essentially unknown; some tantalizing information suggests widespread daily timekeeping among Eubacteria and Archaea through mechanisms that share common elements with the cyanobacterial clock but are distinct...
February 20, 2017: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/28215869/a-novel-assembly-pheromone-trap-for-tick-control-in-dog-kennels
#15
R K Anish, Bhaskaran Ravi Latha, Giriprasath Ramanathan, Uma Tirichurapalli Sivagnanam, C Sreekumar, V Leela
A novel ecofriendly sticky tick trap device for the control of dog tick Rhipicephalus sanguineus using gold nanoparticle assembly pheromone complex as a bait was developed. Assembly pheromones comprising of guanine, xanthine and adenine in the ratio of 25:1:1 was encapsulated in gold nanoparticle. The response of the different stages of unfed R. sanguineus ticks was evaluated using petridish bioassay. Statistical analysis was done using chi-square test. Petridish bioassay with unfed stages of R. sanguineus revealed that 100% of the larvae, nymph and adults were attracted to assembly pheromone nanogold complex within 24h...
February 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28215860/the-use-of-infrared-images-to-detect-ticks-in-cattle-and-proposal-of-an-algorithm-for-quantifying-the-infestation
#16
Jayme Garcia Arnal Barbedo, Claudia Cristina Gulias Gomes, Fernando Flores Cardoso, Robert Domingues, Jeferson Vidart Ramos, Concepta Margaret McManus
This paper presents a study on the use of low resolution infrared images to detect ticks in cattle. Emphasis is given to the main factors that influence the quality of the captured images, as well as to the actions that can increase the amount of information conveyed by these images. In addition, a new automatic method for analyzing the images and counting the ticks is introduced. The proposed algorithm relies only on color transformations and simple mathematical morphology operations, thus being easy to implement and computationally light...
February 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28215226/transcription-factors-as-a-target-for-vaccination-against-ticks-and-mites
#17
O A E Sparagano
Ticks and mites are well-known ectoparasites as potential vectors for numerous bacteria, viruses, and parasites. Many being blood feeders add to physiological deterioration, morbidity, and mortality of their vertebrate hosts. To control them, transcription factors have been identified and studied in their role to sustain such arthropod pests. This paper summarizes some of the work done on those factors involved during blood feeding, reproduction, or when interacting with their pathogens and symbiont populations...
2017: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/28213810/how-to-tackle-natural-focal-infections-from-risk-assessment-to-vaccination-strategies
#18
Luca Busani, Alexander E Platonov, Onder Ergonul, Giovanni Rezza
Natural focal diseases are caused by biological agents associated with specific landscapes. The natural focus of such diseases is defined as any natural ecosystem containing the pathogen's population as an essential component. In such context, the agent circulates independently on human presence, and humans may become accidentally infected through contact with vectors or reservoirs. Some viruses (i.e., tick-borne encephalitis and Congo-Crimean hemorrhagic fever virus) are paradigmatic examples of natural focal diseases...
February 18, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28213544/isolation-and-characterization-of-a-unique-strain-of-rickettsia-parkeri-associated-with-the-hard-tick-dermacentor-parumapertus-neumann-in-the-western-united-states
#19
Christopher D Paddock, Michelle E J Allerdice, Sandor E Karpathy, William L Nicholson, Michael L Levin, Travis C Smith, Tom Becker, Robert J Delph, Robert N Knight, Jana M Ritter, Jeanine H Sanders, Jerome Goddard
In 1953, investigators at the Rocky Mountain Laboratories in Hamilton, Montana, described the isolation of a spotted fever group Rickettsia (SFGR) species from Dermacentor parumapertus collected from black-tailed jackrabbits (Lepus californicus) in northern Nevada. Several decades later, investigators characterized this SFGR by using mouse serotyping methods and determined that it represented a distinct rickettsial serotype, related closely to Rickettsia parkeri; nonetheless, the parumapertus agent was not further characterized or studied...
February 17, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28213103/expression-and-characterization-of-haemathrins-madanin-like-thrombin-inhibitors-isolated-from-the-salivary-gland-of-tick-haemaphysalis-bispinosa-acari-ixodidae
#20
Rajeev Kungur Brahma, Guillaume Blanchet, Simran Kaur, R Manjunatha Kini, Robin Doley
Saliva of hematophagous animals, such as ticks, is an excellent source of anticoagulant proteins and polypeptides. Here we describe the identification and characterization of two thrombin inhibitors named as haemathrin 1 and 2 from the salivary gland of tick Haemaphysalis bispinosa using genomic approach. Haemathrins are cysteine-less peptide anticoagulants, which share about 65-70% identity with madanins, and belong to inhibitor I53 superfamily of inhibitors of the MEROPS database. Haemathrins were overexpressed in E...
January 31, 2017: Thrombosis Research
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