Denitsa M Hristova, Takeshi Fukumoto, Chihiro Takemori, Le Gao, Xia Hua, Joshua X Wang, Ling Li, Marilda Beqiri, Andrea Watters, Adina Vultur, Yusra Gimie, Vito Rebecca, Anastasia Samarkina, Haruki Jimbo, Chikako Nishigori, Jie Zhang, Chaoran Cheng, Zhi Wei, Rajasekharan Somasundaram, Mizuho Fukunaga-Kalabis, Meenhard Herlyn
Upregulation of the adaptor protein NUMB triggers melanocytic differentiation from multipotent skin stem cells, which share many properties with aggressive melanoma cells. Although NUMB acts as a tumor suppressor in various human cancer types, little is known about its role in melanoma. Here, we investigated the role of NUMB in melanoma progression and its regulatory mechanism. Analysis of The Cancer Genome Atlas melanoma datasets revealed that high NUMB expression in melanoma tissues correlates with improved patient survival...
December 6, 2021: Journal of Investigative Dermatology