Leomar Y Ballester, Zengfeng Wang, Shaefali Shandilya, Markku Miettinen, Peter C Burger, Charles G Eberhart, Fausto J Rodriguez, Eric Raabe, Javad Nazarian, Katherine Warren, Martha M Quezado
Tumors of the central nervous system are the second most common malignancy in children. In particular, diffuse intrinsic pontine gliomas (DIPGs) are aggressive tumors with poor prognosis and account for 10% to 25% of pediatric brain tumors. The majority of DIPGs are astrocytic, infiltrative, and localized to the pons. Studies have shown median survival times of less than a year, with 90% of children dying within 2 years. We built multitissue arrays with 24 postmortem DIPG samples and analyzed the morphology and expression of several proteins (p53, EGFR, GFAP, MIB1, BMI1, β-catenin, p16, Nanog, Nestin, OCT4, OLIG2, SOX2) with the goal of identifying potential treatment targets and improving our understanding of the biology of these tumors...
September 2013: American Journal of Surgical Pathology