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https://www.readbyqxmd.com/read/28615124/blood-and-milk-polymorphonuclear-leukocyte-and-monocyte-macrophage-functions-in-naturally-caprine-arthritis-encephalitis-virus-infection-in-dairy-goats
#1
Bruna Parapinski Santos, Fernando Nogueira Souza, Maiara Garcia Blagitz, Camila Freitas Batista, Heloísa Godoi Bertagnon, Soraia Araújo Diniz, Marcos Xavier Silva, João Paulo Amaral Haddad, Alice Maria Melville Paiva Della Libera
The exact influence of caprine arthritis encephalitis virus (CAEV) infection on blood and milk polymorphonuclear leukocytes (PMNLs) and monocyte/macrophages of goats remains unclear. Thus, the present study sought to explore the blood and milk PMNL and monocyte/macrophage functions in naturally CAEV-infected goats. The present study used 18 healthy Saanen goats that were segregated according to sera test outcomes into serologically CAEV negative (n=8; 14 halves) and positive (n=10; 14 halves) groups. All milk samples from mammary halves with milk bacteriologically positive outcomes, somatic cell count ≥2×10(6)cellsmL(-1), and abnormal secretions in the strip cup test were excluded...
June 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/28614435/personality-characteristics-and-bariatric-surgery-outcomes-a-systematic-review
#2
Suelen Bordignon, Mayra Juliana Galvis Aparício, Juliana Bertoletti, Clarissa Marceli Trentini
Introduction: Numerous studies have focused on psychological assessment of bariatric surgery candidates, aiming to identify which psychological variables, including personality characteristics, are related to successful surgical prognosis. Objective: To analyze, by means of a systematic literature review, longitudinal studies that investigated personality traits and disorders as possible predictors of outcomes in bariatric surgery. Method: PsycInfo, PubMed, and Scopus databases were searched for studies published between 2005 and 2015, using the keywords "bariatric" AND "personality...
June 12, 2017: Trends in Psychiatry and Psychotherapy
https://www.readbyqxmd.com/read/28609179/maternal-distress-and-the-development-of-hypertensive-disorders-of-pregnancy
#3
Idalia Garza-Veloz, Claudia Castruita-De la Rosa, Yolanda Ortiz-Castro, Virginia Flores-Morales, Maria E Castañeda-Lopez, Edith Cardenas-Vargas, Gloria P Hernandez-Delgadillo, Vicente Ortega-Cisneros, Martha Luevano, Iram P Rodriguez-Sanchez, Fabiola Trejo-Vazquez, Ivan Delgado-Enciso, Miguel A Cid-Baez, Perla M Trejo-Ortiz, Maria G Ramos-Del Hoyo, Margarita L Martinez-Fierro
Despite the implementation of programmes to improve maternal health, maternal and foetal mortality rates still remain high. The presence of maternal distress and its association with the development of pregnancy hypertensive disorders is not well established. The aim of this study was to evaluate the association between maternal distress and the development of hypertensive disorders in pregnancy in a prospective cohort of 321 Mexican women. Symptoms of maternal distressing were evaluated at week 20th of gestation using the General Health Questionnaire...
June 13, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28604073/-fear-and-avoidance-beliefs-in-chronic-pain-the-translation-and-validation-of-the-hungarian-version-of-the-fabq-questionnaire
#4
Eszter Simoncsics, Adrienne Stauder
INTRODUCTION: Chronic low back pain is one of the top reasons for seeking medical advice. In the background of the dysfunction besides the somatic pain dysfunctional thinking, negative emotional states, or interpersonal problems can be identified as well. One of the most important factors making the rehabilitation difficult is the fear and avoidance of physical activity. AIM: The aim of the study was to adapt and validate the Fear Avoidance Beliefs Questionnaire (FABQ-H) in Hungarian...
June 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28597146/human-i%C3%AE%C2%BAb%C3%AE-gain-of-function-a-severe-and-syndromic-immunodeficiency
#5
REVIEW
Bertrand Boisson, Anne Puel, Capucine Picard, Jean-Laurent Casanova
Germline heterozygous gain-of-function (GOF) mutations of NFKBIA, encoding IκBα, cause an autosomal dominant (AD) form of anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID). Fourteen unrelated patients have been reported since the identification of the first case in 2003. All mutations enhanced the inhibitory activity of IκBα, by preventing its phosphorylation on serine 32 or 36 and its subsequent degradation. The mutation certainly or probably occurred de novo in 13 patients, whereas it was inherited from a parent with somatic mosaicism in one patient...
June 9, 2017: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/28595809/neuroticism-in-child-sex-offenders-and-its-association-with-sexual-dysfunctions-cognitive-distortions-and-psychological-complaints
#6
Coralie Boillat, Gunnar Deuring, Marlon O Pflueger, Marc Graf, Timm Rosburg
Studies in child sex offenders (CSO) often report deviant personality characteristics. In our study, we investigated neuroticism in CSO and tested the hypothesis that CSO with high neuroticism show more serious abuse behavior and are more likely to exhibit sexual dysfunction and cognitive distortions, as compared to CSO with low neuroticism. A sample of 40 CSO (both child sexual abusers and child sexual material users) was split into two subsamples based on their neuroticism scores, obtained by the NEO-Personality Inventory-Revised (NEO-PI-R) questionnaire...
June 5, 2017: International Journal of Law and Psychiatry
https://www.readbyqxmd.com/read/28593138/licochalcone-a-specifically-induces-cell-death-in-glioma-stem-cells-via-mitochondrial-dysfunction
#7
Kenta Kuramoto, Shuhei Suzuki, Hirotsugu Sakaki, Hiroyuki Takeda, Tomomi Sanomachi, Shizuka Seino, Yoshitaka Narita, Takamasa Kayama, Chifumi Kitanaka, Masashi Okada
Glioblastoma multiforme is the most malignant primary intrinsic brain tumor. Glioma stem cells (GSCs) are associated with chemoradiotherapy resistance and the recurrence of glioblastomas after conventional therapy. The targeting of GSCs is potentially an effective treatment for the long-term survival of glioblastoma patients. Licochalcone A, a natural chalconoid from licorice root, exerts anticancer effects; however, its effect on GSCs remains unknown. We found that Licochalcone A induced massive caspase-dependent death in GSCs but not in differentiated GSCs nor normal somatic and neural stem cells...
June 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/28578035/spontaneous-variation-regarding-grape-berry-skin-color-a-comprehensive-study-of-berry-development-by-means-of-biochemical-and-molecular-markers
#8
Vanessa Ferreira, Fátima Fernandes, David Carrasco, Marivel Gonzalez Hernandez, Olinda Pinto-Carnide, Rosa Arroyo-García, Paula Andrade, Patrícia Valentão, Virgílio Falco, Isaura Castro
Understanding grape berry development and the metabolism of different classes of compounds responsible for traits like berry's color is imperative to control and improve quality aspects of grapes. A colorimetric, biochemical and molecular characterization allowed the comprehensive description of the pigment-related characteristics of nine berry skin color somatic variants, belonging to four different varieties. Although the observed berry skin color variability was not fully explained by MybA locus, the phenolic profiles allowed inferring about specific interferences among the biosynthetic pathways...
July 2017: Food Research International
https://www.readbyqxmd.com/read/28572738/sleep-and-somatic-complaints-in-university-students
#9
Angelika A Schlarb, Merle Claßen, Sara M Hellmann, Claus Vögele, Marco D Gulewitsch
BACKGROUND: Sleep problems are common among university students. Poor sleep is associated with impaired daily functioning, increased risk of psychiatric symptoms, and somatic complaints such as pain. Previous results suggest that poor sleep exacerbates pain, which in turn negatively affects sleep. The purpose of the present study was to determine prevalence rates, comorbidity, and role of depression as a factor of moderating the relationship between sleep and physical complaints in German university students...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28562315/aged-induced-pluripotent-stem-cell-ipscs-as-a-new-cellular-model-for-studying-premature-aging
#10
Stefania Petrini, Rossella Borghi, Valentina D'Oria, Fabrizia Restaldi, Sandra Moreno, Antonio Novelli, Enrico Bertini, Claudia Compagnucci
Nuclear integrity and mechanical stability of the nuclear envelope (NE) are conferred by the nuclear lamina, a meshwork of intermediate filaments composed of A- and B-type lamins, supporting the inner nuclear membrane and playing a pivotal role in chromatin organization and epigenetic regulation. During cell senescence, nuclear alterations also involving NE architecture are widely described. In the present study, we utilized induced pluripotent stem cells (iPSCs) upon prolonged in vitro culture as a model to study aging and investigated the organization and expression pattern of NE major constituents...
May 31, 2017: Aging
https://www.readbyqxmd.com/read/28557820/features-of-resting-state-eeg-theta-coherence-in-somatic-symptom-disorder-compared-to-major-depressive-disorder-a-pilot-study
#11
Jaeyoung Ahn, Doug Hyun Han, Ji Sun Hong, Kyoung Joon Min, Young Sik Lee, Bong-Jin Hahm, Sun Mi Kim
OBJECTIVE: Somatic symptom disorder (SSD) often co-occurs with major depressive disorder (MDD). Both conditions share common psychobiological and biobehavioral characteristics, but little is known about differential patterns in brain function. In this study, we compared resting-state functional brain connectivity between SSD and MDD using quantitative electroencephalography (QEEG). METHODS: Fifteen patients with SSD (SSD group), 15 patients with MDD (MDD group), and 15 healthy volunteers (HC group) participated in this study...
May 27, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28556863/use-of-the-fascial-distortion-model-to-evaluate-a-limp-in-a-child
#12
Sarah J James, Jasmine Hudnall
Pediatric limp is a relatively common condition in primary care and can be challenging to diagnose and manage. Common causes of painful pediatric limp include transient synovitis, septic arthritis, osteomyelitis, and trauma. The authors present the case of an 11-year-old girl with a painful limp and anterior ankle pain of unclear origin. Osteopathic structural examination revealed a somatic dysfunction known as continuum distortion, 1 of 6 fascial alterations identified in the fascial distortion model. Myofascial release was applied, providing rapid, complete resolution of symptoms...
June 1, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/28515561/efficacy-of-myofascial-unwinding-and-myofascial-release-technique-in-a-patient-with-somatic-symptoms-a-case-report
#13
Manu Goyal, Kanu Goyal, Manish Bathla, D Kanimozhi, D Narkeesh
Depression is an aversion to activity disorder which could lead to somatic dysfunctions such as insomnia, excessive sleeping, body aches, listlessness, and irritable bowel syndrome. The World Health Organization has projected the depression to be the second leading cause of disability worldwide by 2020. The physical and mental ill effects of somatic depression can be addressed using the osteopathic manipulative treatment. Therefore, the purpose of the present case report is to explore the effect of myofascial release (MFR) technique and myofascial unwinding (MFU) in the somatic depression...
March 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28506304/characterization-of-genetic-aberrations-in-a-single-case-of-metastatic-thymic-adenocarcinoma
#14
Yeonghun Lee, Sehhoon Park, Se-Hoon Lee, Hyunju Lee
BACKGROUND: Thymic adenocarcinoma is an extremely rare subtype of thymic epithelial tumors. Due to its rarity, there is currently no sequencing approach for thymic adenocarcinoma. METHODS: We performed whole exome and transcriptome sequencing on a case of thymic adenocarcinoma and performed subsequent validation using Sanger sequencing. RESULTS: The case of thymic adenocarcinoma showed aggressive behaviors with systemic bone metastases. We identified a high incidence of genetic aberrations, which included somatic mutations in RNASEL, PEG10, TNFSF15, TP53, TGFB2, and FAT1...
May 15, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28504110/neurological-consequences-of-obesity
#15
REVIEW
Phillipe D O'Brien, Lucy M Hinder, Brian C Callaghan, Eva L Feldman
The high prevalence of obesity is associated with an enormous medical, social, and economic burden. The metabolic dysfunction, dyslipidaemia, and inflammation caused by obesity contribute to the development of a wide variety of disorders and effects on the nervous system. In the CNS, mild cognitive impairment can be attributed to obesity-induced alterations in hippocampal structure and function in some patients. Likewise, compromised hypothalamic function and subsequent defects in maintaining whole-body energy balance might be early events that contribute to weight gain and obesity development...
June 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28502718/mitochondrial-nd5-mutation-mediated-elevated-ros-regulates-apoptotic-pathway-epigenetically-in-a-p53-dependent-manner-for-generating-pro-cancerous-phenotypes
#16
Rajnish Kumar Singh, Sunil Saini, Dileep Verma, Ponnusamy Kalaiarasan, Rameshwar N K Bamezai
We have previously observed concomitant events of mutations in mitochondrial and nuclear genes, along with elevated reactive oxygen species (ROS) and differential methylation within the promoters of nuclear genes in tumors and in vitro experiments of tumorigenesis. These observations have made it pertinent to replicate and understand the role of acquired mitochondrial condition in tuning a cell to accomplish a pro-cancerous state. Using a codon optimized vector system for exogenous over-expression and mitochondrial localization; we have characterized here the role of over-expressed wild type mtND5 and one of its non-synonymous somatic mutation, ND5:P265H...
May 11, 2017: Mitochondrion
https://www.readbyqxmd.com/read/28487205/mitochondrial-determinants-of-cancer-health-disparities
#17
REVIEW
Aaheli Roy Choudhury, Keshav K Singh
Mitochondria are involved in the generation of energy, cell growth and differentiation, cellular signaling, cell cycle control, and cell death. To date, the mitochondrial basis of cancer disparities is unknown. The goal of this review is to provide an understanding and a framework of mitochondrial determinants that may contribute to cancer disparities in racially different populations. Mitochondria, which are multi-functional, have been implicated in the initiation and progression of cancers in relation to metabolic alterations in transformed cells...
May 6, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28472273/ebt-a-statistic-test-identifying-moderate-size-of-significant-features-with-balanced-power-and-precision-for-genome-wide-rate-comparisons
#18
Xinjie Hui, Yueming Hu, Ming-An Sun, Xingsheng Shu, Rongfei Han, Qinggang Ge, Yejun Wang
Motivation: In genome-wide rate comparison studies, there is a big challenge for effective identification of an appropriate number of significant features objectively, since traditional statistical comparisons without multi-testing correction can generate a large number of false positives while multi-testing correction tremendously decrease the statistic power. Results: In this study, we proposed a new exact test based on the translation of rate comparison to two binomial distributions...
May 3, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28468842/novel-mutations-in-dystonin-provide-clues-to-the-pathomechanisms-of-hsan-vi
#19
Fiore Manganelli, Silvia Parisi, Maria Nolano, Feifei Tao, Simona Paladino, Chiara Pisciotta, Stefano Tozza, Claudia Nesti, Adriana P Rebelo, Vincenzo Provitera, Filippo M Santorelli, Michael E Shy, Tommaso Russo, Stephan Zuchner, Lucio Santoro
OBJECTIVE: To describe a second hereditary sensory autonomic neuropathy type VI (HSAN-VI) family harboring 2 novel heterozygous mutations in the dystonin (DST) gene and to evaluate their effect on neurons derived from induced pluripotent stem cells (iPSC). METHODS: The family consisted of 3 affected siblings from nonconsanguineous healthy parents. All members underwent clinical and electrophysiologic evaluation and genetic analysis. Two patients underwent quantitative sensory testing (QST), cardiovascular reflexes, dynamic sweat test, and skin biopsy to evaluate somatic and autonomic cutaneous innervation and to get fibroblast cultures for developing iPSC-derived neurons...
May 30, 2017: Neurology
https://www.readbyqxmd.com/read/28438607/obesity-exposed-oocytes-accumulate-and-transmit-damaged-mitochondria-due-to-an-inability-to-activate-mitophagy
#20
Anna L Boudoures, Jessica Saben, Andrea Drury, Suzanne Scheaffer, Zeel Modi, Wendy Zhang, Kelle H Moley
Mitochondria are the most prominent organelle in the oocyte. Somatic cells maintain a healthy population of mitochondria by degrading damaged mitochondria via mitophagy, a specialized autophagy pathway. However, evidence from previous work investigating the more general macroautophagy pathway in oocytes suggests that mitophagy may not be active in the oocyte. This would leave the vast numbers of mitochondria - poised to be inherited by the offspring - vulnerable to damage. Here we test the hypothesis that inactive mitophagy in the oocyte underlies maternal transmission of dysfunctional mitochondria...
April 21, 2017: Developmental Biology
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