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https://www.readbyqxmd.com/read/29132836/prevalence-of-fabry-disease-in-young-patients-with-stroke-in-argentina
#1
Ricardo C Reisin, Julieta Mazziotti, Luciana León Cejas, Alberto Zinnerman, Pablo Bonardo, Manuel Fernández Pardal, Alejandra Martínez, Patricia Riccio, Sebastián Ameriso, Eduardo Bendersky, Pedro Nofal, Patricia Cairola, Lorena Jure, Andrea Sotelo, Paula Rozenfeld, Romina Ceci, Ignacio Casas-Parera, Analía Sánchez Luceros
BACKGROUND: Fabry disease (FD) is an underdiagnosed cause of stroke in young adults, but the frequency of this association is largely unknown. We estimated the prevalence of FD in a nationwide cohort of young adults who had stroke and transient ischemic attack (TIA) in Argentina. METHODS: This was a prospective, multicenter study of stroke and FD in young adults (18-55 years) conducted in Argentina between 2011 and 2015. Patients were enrolled if they had had a TIA or an ischemic or hemorrhagic stroke within the previous 180 days...
November 10, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29128012/noninfectious-acute-lung-injury-syndromes-early-after-hematopoietic-stem-cell-transplantation
#2
REVIEW
Vivek N Ahya
Noninfectious acute lung injury syndromes are major causes of respiratory failure and early mortality after hematopoietic stem cell transplantation (HSCT). Pulmonary edema and transfusion-related acute lung injuries are important respiratory complications seen after HSCT and in the nontransplant setting. Early transplant-specific causes of lung injury, such as idiopathic pneumonia syndrome, are reviewed. Several complications, such as drug-induced pneumonitis and cryptogenic organizing pneumonia, that occur in both the early and later time periods after HSCT are also briefly discussed...
December 2017: Clinics in Chest Medicine
https://www.readbyqxmd.com/read/29123846/two-cases-of-cryptogenic-life-threatening-hemoptysis-identification-and-management-of-bleeding-point
#3
Kazunori Okuda, Jun Tanaka, Jun Okamoto, Fumihisa Kishi, Junichiro Nakagawa, Hiroshi Hino, Satoru Chujoh, Kazuhisa Shimadzu, Masafumi Kishimoto, Noboru Kato, Shigeru Shiono
Cases: Case 1: A 63-year-old woman was referred for coughing blood. Although cardiorespiratory dynamics were stabilized by artificial respiration under sedation, severely poor ventilation developed from asphyxia associated with massive respiratory tract hemorrhage. One-lung ventilation was temporarily secured by endotracheal tube insertion into the left main bronchus just prior to cardiopulmonary arrest.Case 2: A 72-year-old man was referred for massive hemoptysis after coughing, then intubated and placed on a respirator...
January 2017: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29111018/embolic-stroke-of-undetermined-source-the-role-of-the-nonstenotic-carotid-plaque
#4
Zachary Bulwa, Ajay Gupta
Cryptogenic stroke, or stroke of undetermined cause, presents a remarkably challenging dilemma for the treating physician as there are limited therapeutic options to prevent recurrence. Roughly one third of transient ischemic attacks (TIAs) and ischemic strokes are classified as cryptogenic, with an even greater proportion in young patients. While classification systems have been successfully used in trials to refine therapeutic approaches specific to subtype, there has been little progress made in secondary prevention of cryptogenic stroke...
November 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29110774/epilepsy
#5
Susanne Fauser, Hayrettin Tumani
Epilepsy is worldwide one of the most common neurologic diseases (prevalence 0.5-1%). The diagnostic procedure following a first epileptic seizure includes cerebral imaging, blood examinations, electroencephalography, and an investigation of the cerebrospinal fluid (CSF) in patients seen soon after a seizure in order to exclude dangerous causes which require immediate treatment. Basic CSF investigation comprises the determination of cell counts, glucose, and lactate levels in serum and CSF and of albumin, immunoglobulins, and their quotients...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29107360/yield-of-atrial-fibrillation-detection-with-textile-wearable-holter-from-the-acute-phase-of-stroke-pilot-study-of-crypto-af-registry
#6
Jorge Pagola, Jesus Juega, Jaume Francisco-Pascual, Angel Moya, Mireia Sanchis, Alejandro Bustamante, Anna Penalba, Maria Usero, Elisa Cortijo, Juan F Arenillas, Ana I Calleja, Maria Sandin-Fuentes, Jeronimo Rubio, Fernando Mancha, Irene Escudero-Martinez, Francisco Moniche, Reyes de Torres, Soledad Pérez-Sánchez, Carlos E González-Matos, Ángela Vega, Alonso A Pedrote, Eduardo Arana-Rueda, Joan Montaner, Carlos A Molina
BACKGROUND: We describe the feasibility of monitoring with a Textile Wearable Holter (TWH) in patients included in Crypto AF registry. METHODS: We monitored cryptogenic stroke patients from stroke onset (<3days) continuously during 28days. We employed a TWH composed by a garment and a recorder. We compared two garments (Lead and Vest) to assess rate of undiagnosed Atrial Fibrillation (AF) detection, monitoring compliance, comfortability (1 to 5 points), skin lesions, and time analyzed...
October 22, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29093978/should-serum-protein-electrophoresis-be-a-surrogate-for-liver-biopsy-in-some-cases-of-alpha1-antitrypsin-deficiency
#7
Newton Key Hokama, Marcelo Padovani de Toledo Moraes, Paula de Oliveira Montandon Hokama, Fernando Gomes Romeiro
Most patients with alpha1 antitrypsin deficiency do not receive this diagnosis until developing severe complications, in particular when respiratory symptoms are absent. This is a reason for making alpha1 antitrypsin deficiency a possible diagnosis among patients with cryptogenic cirrhosis or other conditions of liver disease without a clear etiology. In this report, a case of cryptogenic cirrhosis is presented, showing the role of serum protein electrophoresis in the diagnosis, which was made before liver biopsy...
2017: Case Reports in Hepatology
https://www.readbyqxmd.com/read/29090662/cryptogenic-stroke
#8
Geoffrey A Donnan
No abstract text is available yet for this article.
December 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/29090661/patent-foramen-ovale-closure-with-gore-helex-or-cardioform-septal-occluder-vs-antiplatelet-therapy-for-reduction-of-recurrent-stroke-or-new-brain-infarct-in-patients-with-prior-cryptogenic-stroke-design-of-the-randomized-gore-reduce-clinical-study
#9
Scott E Kasner, Lars Thomassen, Lars Søndergaard, John F Rhodes, Coby C Larsen, Joth Jacobson
Rationale The utility of patent foramen ovale (PFO) closure for secondary prevention in patients with prior cryptogenic stroke is uncertain despite multiple randomized trials completed to date. Aims The Gore REDUCE Clinical Study (REDUCE) aims to establish superiority of patent foramen ovale closure in conjunction with antiplatelet therapy over antiplatelet therapy alone in reducing the risk of recurrent clinical ischemic stroke or new silent brain infarct in patients who have had a cryptogenic stroke. Methods and design This controlled, open-label trial randomized 664 subjects with cryptogenic stroke at 63 multinational sites in a 2:1 ratio to either antiplatelet therapy plus patent foramen ovale closure (with GORE® HELEX® Septal Occluder or GORE® CARDIOFORM Septal Occluder) or antiplatelet therapy alone...
December 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/29089708/recurrent-hepatocellular-carcinoma-in-the-right-adrenal-gland-11%C3%A2-years-after-liver-transplantation-for-hepatocellular-carcinoma-a-case-report-and-literature-review
#10
REVIEW
Ismail Cem Sormaz, Gülçin Yegen, Filiz Akyuz, Fatih Tunca, Yasemin Giles Şenyürek
Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver, and extrahepatic metastases are typically found during disease progression. The incidence of adrenal metastasis (AM) from HCC in autopsy series ranges from 4.6 to 12.5%, and it is the second most common site of metastasis after the lungs. To date, there have been few reports of patients who underwent adrenalectomy for isolated AM from HCC after liver transplantation (LT). A woman aged 55 years was referred to our clinic for the evaluation of a right adrenal mass that was detected by abdominal ultrasonography at another center...
October 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/29081978/device-closure-for-patent-foramen-ovale-following-cryptogenic-stroke-a-survey-of-current-practice-in-the-uk
#11
Katherine Von Klemperer, Aleksander Kempny, Christopher William Pavitt, John C Janssen, Anselm Uebing, Edward Nicol
Patent foramen ovale (PFO) closure for cryptogenic stroke remains controversial due to a lack of conclusive randomised controlled data. Many experts feel PFO closure is indicated in selected cases; however, national and international guideline recommendations differ. We surveyed the UK cardiologists, stroke physicians and neurologists, seeking to determine specialist interpretation of the evidence base, and to gain an insight into the current UK practice. The British Cardiac Society and British Society of Stroke physicians distributed our survey which was performed using an online platform...
2017: Open Heart
https://www.readbyqxmd.com/read/29075369/acute-on-chronic-liver-failure-in-a-multi-ethnic-asian-city-a-comparison-of-patients-identified-by-asia-pacific-association-for-the-study-of-the-liver-and-european-association-for-the-study-of-the-liver-definitions
#12
Anandraj Selva Rajoo, Seng-Gee Lim, Wah Wah Phyo, Thandar Tun, Yock-Young Dan, Yin-Mei Lee, How-Cheng Low, Kieron Lim, Poh-Seng Tan, Guan-Huei Lee
AIM: To explore the applicability of the Asia-Pacific Association for the Study of the Liver (APASL) and European Association for the Study of the Liver (EASL) guidelines for acute-on-chronic liver failure (ACLF) in profiling patients and determining the outcome. METHODS: Patients admitted to a tertiary hospital in Singapore with acute decompensation of liver disease from January 2004 to July 2014 are screened for ACLF according to the APASL and EASL criteria. The patients' data (including basic demographics, information about existing chronic liver disease, information about the acute decompensation, relevant laboratory values during admission, treatment, and outcome) are retrospectively analyzed to determine the background, precipitating factors and outcome...
October 8, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/29068141/interventional-closure-of-patent-foramen-ovale-with-nit-occlud%C3%A2-device-in-prevention-of-recurrent-neurologic-events-long-term-results
#13
Aleksander Araszkiewicz, Sylwia Sławek, Olga Trojnarska, Maciej Lesiak, Marek Grygier
BACKGROUND: Patent foramen ovale (PFO) was found to be associated with the increased risk of recurrent strokes or transient ischemic attacks (TIA) and there is a need of secondary prevention. Numerous devices have been developed and used for treatment. OBJECTIVES: The aim of the study was to evaluate the safety and effectiveness of a new PFO occluder Nit-Occlud PFO Occlusion Device (PFM medical, Germany). METHODS: Between January 2012 and August 2016, 151 patients (mean age 41 ± 11 years) who had suffered from a cryptogenic thromboembolic event underwent transcatheter PFO closure with the PFM Nit-Occlud PFO device...
October 25, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29067123/alcoholization-of-pyogenichepatic-abscess-with-absolute-alcohol-in-bama-minipigs
#14
Ru-Gang Zhang, Xiu-Li Zhang, Yun-Sheng Yang
Pyogenic hepatic abscess (PHA) is a rare, but potentially serious disease. At present, ultrasound-guided or computed tomography-guided percutaneous needle aspiration or catheter drainage is appropriate as a first-line treatment. However, it is difficult to aspirate or drain pus and to select the appropriate antibiotic therapy if the abscess consists of thick pus and polymicrobial confections, or its pathogenic bacterium is multidrug resistant and cryptogenic. Case studies of alcoholization provide a novel method to manage PHA...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29061502/organizing-pneumonia-contemplate-beyond-cryptogenic
#15
Michael Omar, Sanjeeva Goli, Ian Ramnarine, Sateesh Sakhamuri
No abstract text is available yet for this article.
October 20, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/29056952/acute-inferior-st-segment-elevation-myocardial-infarction-and-previous-cryptogenic-stroke-caused-by-a-paradoxical-embolism-with-a-concomitant-pulmonary-embolism
#16
Hong-Yu Zhang, Yan Zhang, Yan-Jun Cao, Lian-Lian Mei, Xia Zhang, Zhi-Guo Wu, Bao-Hua Qiu, Shu-Jing Wang
No abstract text is available yet for this article.
June 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29055934/cryptogenic-cirrhosis-and-sitosterolemia-a-treatable-disease-if-identified-but-fatal-if-missed
#17
Fateh Bazerbachi, Erin E Conboy, Taofic Mounajjed, Kymberly D Watt, Dusica Babovic-Vuksanovic, Shailendra B Patel, Patrick S Kamath
Sitosterolemia is an autosomal recessive metabolic disease caused by mutations in ABCG5 or ABCG8 genes which encode for the (ATP)-binding cassette (ABC) transporters that are responsible for the trafficking of xenosterols. Liver involvement is not a recognized manifestation of this disease, and cirrhosis has been reported only once in the medical literature. We describe a fatal case of a 21-year old South Asian male who presented with decompensated cirrhosis, and biochemical abnormalities consistent with sitosterolemia...
October 16, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/29051340/attenuation-of-myeloid-specific-tgf%C3%AE-signaling-induces-inflammatory-cerebrovascular-disease-and-stroke
#18
M C Hollander, Lawrence L Latour, Dan Yang, Hiroki Ishii, Zhiguang Xiao, Yongfen Min, Abhik Ray-Choudhury, Jeeva Munasinghe, Anand S Merchant, P C Lin, John Hallenbeck, Manfred Boehm, Li Yang
Rationale: Cryptogenic strokes, those of unknown cause, have been estimated as high as 30-40% of strokes. Inflammation has been suggested as a critical etiological factor. However, there is lack of experimental evidence. Objective: In this study, we investigated inflammation associated stroke etiology using a mouse model that developed spontaneous stroke due to myeloid deficiency of TGFβ signaling. Methods and Results: We report that mice with deletion of Tgfbr2 in myeloid cells (Tgfbr2(Myeko)) developed cerebrovascular inflammation in the absence of significant pathology in other tissues, culminating in stroke and severe neurological deficits with 100% penetrance...
October 19, 2017: Circulation Research
https://www.readbyqxmd.com/read/29050462/a-growing-hepatic-mass-in-a-cryptogenic-cirrhosis-patient
#19
Ji Soo Song, Hee Chul Yu, Woo Sung Moon
No abstract text is available yet for this article.
October 19, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29045023/more-advanced-disease-and-worse-survival-in-cryptogenic-compared-to-viral-hepatocellular-carcinoma
#20
Tomi W Jun, Ming-Lun Yeh, Ju Dong Yang, Vincent L Chen, Pauline Nguyen, Nasra H Giama, Chung-Feng Huang, Ann W Hsing, Chia-Yen Dai, Jee-Fu Huang, Wan-Long Chuang, Lewis R Roberts, Ming-Lung Yu, Mindie H Nguyen
BACKGROUND & AIMS: Although hepatitis B virus (HBV) and hepatitis C virus (HCV) infections remain major risk factors for hepatocellular carcinoma (HCC), non-viral causes of HCC, particularly non-alcoholic fatty liver disease, are becoming increasingly prevalent. The aim of this study was to compare the clinical characteristics and survival of cryptogenic and viral HCC. METHODS: We conducted a retrospective cohort study involving 3,878 consecutive HCC patients seen at two tertiary centers in the United States and one in Taiwan from 2004-2014...
October 16, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
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