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https://www.readbyqxmd.com/read/29228315/comparison-of-neoadjuvant-nab-paclitaxel-carboplatin-vs-nab-paclitaxel-gemcitabine-in-triple-negative-breast-cancer-randomized-wsg-adapt-tn-trial-results
#1
Oleg Gluz, Ulrike Nitz, Cornelia Liedtke, Matthias Christgen, Eva-Maria Grischke, Helmut Forstbauer, Michael Braun, Mathias Warm, John Hackmann, Christoph Uleer, Bahriye Aktas, Claudia Schumacher, Nikola Bangemann, Christoph Lindner, Sherko Kuemmel, Michael Clemens, Jochem Potenberg, Peter Staib, Andreas Kohls, Raquel von Schumann, Ronald Kates, Ronald Kates, Johannes Schumacher, Rachel Wuerstlein, Hans Heinrich Kreipe, Nadia Harbeck
Background: Pathological complete response (pCR) is associated with improved prognosis in triple-negative breast cancer (TNBC). The optimal chemotherapy regimen is unclear. Weekly nab-paclitaxel vs conventional paclitaxel or addition of carboplatin to anthracycline-taxane results in higher pCR rates with uncertain survival impact. We evaluated carboplatin vs gemcitabine with a nab-paclitaxel backbone as a short 12-week A-free regimen with a focus on early response. Methods: Patients with TNBC (estrogen receptor/progesterone receptor < 1%, human epidermal growth factor receptor 2-negative, cT1c-cT4c, cN0/+) were randomly assigned to A: nab-paclitaxel 125 mg/m2/gemcitabine 1000 mg/m2 d1,8 three times weekly (q3w); vs B: nab-paclitaxel 125 mg/m2/carboplatin AUC2 day 1,8 q3w...
December 8, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29226152/the-phytoestrogen-genistein-produces-similar-effects-as-17%C3%AE-estradiol-on-anxiety-like-behavior-in-rats-at-12-weeks-after-ovariectomy
#2
Juan Francisco Rodríguez-Landa, Jonathan Cueto-Escobedo, Abraham Puga-Olguín, Eduardo Rivadeneyra-Domínguez, Blandina Bernal-Morales, Emma Virginia Herrera-Huerta, Andrea Santos-Torres
The phytoestrogen genistein produces anxiolytic-like effects in ovariectomized rats, which highlights its potential therapeutic effect in ameliorating anxiety in surgical menopausal women. However, no studies have directly compared the effects of identical doses of genistein and 17β-estradiol, the main estrogen used in hormone replacement therapy in menopausal women. The present study evaluated the anxiolytic-like effects of identical doses of genistein and 17β-estradiol (0.045, 0.09, and 0.18 mg/kg/7 days, s...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29226072/a-thermal-gradient-modulates-the-oxidative-metabolism-and-growth-of-human-keratinocytes
#3
Marta Viano, Daniela Alotto, Alessia Aillon, Carlotta Castagnoli, Francesca Silvagno
During their spatial and differentiative progression, keratinocytes face a thermal gradient, from 37 °C in the proliferating basal layer to 32 °C found in skin surface. In our study, we hypothesized that this difference in temperature must be balanced by increasing the heat produced during respiratory activity. We demonstrated that at 33 °C human primary keratinocytes and HaCaT cells raised mitochondrial energy metabolism, but not glycolytic activity. At 33 °C, the increased mitochondrial ATP synthesis was associated with a strong induction of the modulator of the respiratory chain estrogen receptor β, whereas uncoupling protein 1 expression was not changed...
December 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/29225604/transcriptional-regulation-of-t-cell-lipid-metabolism-implications-for-plasma-membrane-lipid-rafts-and-t-cell-function
#4
REVIEW
George A Robinson, Kirsty E Waddington, Ines Pineda-Torra, Elizabeth C Jury
It is well established that cholesterol and glycosphingolipids are enriched in the plasma membrane (PM) and form signaling platforms called lipid rafts, essential for T-cell activation and function. Moreover, changes in PM lipid composition affect the biophysical properties of lipid rafts and have a role in defining functional T-cell phenotypes. Here, we review the role of transcriptional regulators of lipid metabolism including liver X receptors α/β, peroxisome proliferator-activated receptor γ, estrogen receptors α/β (ERα/β), and sterol regulatory element-binding proteins in T-cells...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29225599/promoter-specificity-and-efficacy-in-conditional-and-inducible-transgenic-targeting-of-lung-macrophages
#5
Alexandra L McCubbrey, Kristen C Allison, Alisa B Lee-Sherick, Claudia V Jakubzick, William J Janssen
Conditional and inducible Cre-loxP systems are used to target gene deletion to specific cell lineages and tissues through promoter-restricted expression of the bacterial DNA recombinase, Cre. Although Cre-loxP systems are widely used to target gene deletion in lung macrophages, limited data are published on the specificity and efficiency of "macrophage targeting" Cre lines. Using R26-stopfl/fl-TdTomato and tetOn-GFP reporter lines, we assessed the specificity and efficiency of four commercially available Cre driver lines that are often considered "macrophage specific...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29224741/identification-of-d-seco-modified-steroid-derivatives-with-affinity-for-estrogen-receptor-%C3%AE-and-%C3%AE-isoforms-using-a-non-transcriptional-fluorescent-cell-assay-in-yeast
#6
Sofija S Bekić, Maja A Marinović, Edward T Petri, Marija N Sakač, Andrea R Nikolić, Vesna V Kojić, Andjelka S Ćelić
Synthesis and biological evaluation of steroidal derivatives with anticancer properties is an active area of drug discovery. Here we measured the relative affinities of D-seco modified steroidal derivatives for estrogen receptor α, estrogen receptor β or androgen receptor ligand binding domains using an optimized non-transcriptional fluorescent cell assay in yeast. Ligand binding domains of steroid receptors were expressed in-frame with yellow fluorescent protein in the yeast Sacharomyces cerevisiae. Addition of known steroid ligands to yeast expressing the appropriate cognate receptor results in increased fluorescence intensity, enabling estimation of receptor binding affinities in a dose-response and time-dependent manner...
December 7, 2017: Steroids
https://www.readbyqxmd.com/read/29224106/g-protein-coupled-estrogen-receptor-gper-and-sex-specific-metabolic-homeostasis
#7
Geetanjali Sharma, Eric R Prossnitz
Obesity and metabolic syndrome display disparate prevalence and regulation between males and females. Human, as well as rodent, females with regular menstrual/estrous cycles exhibit protection from weight gain and associated chronic diseases. These beneficial effects are predominantly attributed to the female hormone estrogen, specifically 17β-estradiol (E2). E2 exerts its actions via multiple receptors, nuclear and extranuclear estrogen receptor (ER) α and ERβ, and the G-protein-coupled estrogen receptor (GPER, previously termed GPR30)...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29224105/nuclear-and-membrane-actions-of-estrogen-receptor-alpha-contribution-to-the-regulation-of-energy-and-glucose-homeostasis
#8
Maeva Guillaume, Alexandra Montagner, Coralie Fontaine, Françoise Lenfant, Jean-François Arnal, Pierre Gourdy
Estrogen receptor alpha (ERα) has been demonstrated to play a key role in reproduction but also to exert numerous functions in nonreproductive tissues. Accordingly, ERα is now recognized as a key regulator of energy homeostasis and glucose metabolism and mediates the protective effects of estrogens against obesity and type 2 diabetes. This chapter attempts to summarize our current understanding of the mechanisms of ERα activation and their involvement in the modulation of energy balance and glucose metabolism...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29224104/the-role-of-estrogens-in-pancreatic-islet-physiopathology
#9
Franck Mauvais-Jarvis, Cedric Le May, Joseph P Tiano, Suhuan Liu, Gamze Kilic-Berkmen, Jun Ho Kim
In rodent models of insulin-deficient diabetes, 17β-estradiol (E2) protects pancreatic insulin-producing β-cells against oxidative stress, amyloid polypeptide toxicity, gluco-lipotoxicity, and apoptosis. Three estrogen receptors (ERs)-ERα, ERβ, and the G protein-coupled ER (GPER)-have been identified in rodent and human β-cells. This chapter describes recent advances in our understanding of the role of ERs in islet β-cell function, nutrient homeostasis, survival from pro-apoptotic stimuli, and proliferation...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29224102/brain-estrogens-and-feeding-behavior
#10
Yong Xu
Estrogens play essential roles in suppressing food intake and preventing body weight gain. Tremendous research efforts have been focused on estrogen physiology in the context of feeding control. Estrogen receptors and the related signals have been attractive targets for development of new obesity therapies. This chapter focuses on the functional interactions between brain estrogens and other appetite-regulatory signals, the critical estrogen receptor isoforms and distinct brain regions that mediate effects of estrogens on feeding, and the intracellular signals that are involved...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29224099/the-role-of-skeletal-muscle-estrogen-receptors-in-metabolic-homeostasis-and-insulin-sensitivity
#11
Andrea L Hevener, Zhenqi Zhou, Brian G Drew, Vicent Ribas
Women in the modern era are challenged with facing menopausal symptoms as well as heightened disease risk associated with increasing adiposity and metabolic dysfunction for up to three decades of life. Treatment strategies to combat metabolic dysfunction and associated pathologies have been hampered by our lack of understanding regarding the biological causes of these clinical conditions and our incomplete understanding regarding the effects of estrogens and the tissue-specific functions and molecular actions of its receptors...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29224098/role-of-estrogens-in-the-regulation-of-liver-lipid-metabolism
#12
Brian T Palmisano, Lin Zhu, John M Stafford
Before menopause, women are protected from atherosclerotic heart disease associated with obesity relative to men. Sex hormones have been proposed as a mechanism that differentiates this risk. In this review, we discuss the literature around how the endogenous sex hormones and hormone treatment approaches after menopause regulate fatty acid, triglyceride, and cholesterol metabolism to influence cardiovascular risk.The important regulatory functions of estrogen signaling pathways with regard to lipid metabolism have been in part obscured by clinical trials with hormone treatment of women after menopause, due to different formulations, routes of delivery, and pairings with progestins...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29224094/sexual-dimorphism-and-estrogen-action-in-mouse-liver
#13
Sara Della Torre, Federica Lolli, Paolo Ciana, Adriana Maggi
Recent studies have demonstrated that in mice, the estrogen receptor alpha (ERα) is expressed in the liver and has a direct effect on the regulation of the hepatic genes relevant for energy metabolism and drug metabolism. The sex-related differential expression of the hepatic ERα raises the questions as to whether this receptor is responsible for the sexual differences observed in the physiopathology of the liver.
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29223656/endometrial-expression-of-estrogen-and-progesterone-receptors-in-non-cyclic-mares-treated-only-with-long-acting-progesterone
#14
L F S Maciel, E S M Silva, J P Oliveira-Filho, S C Fritsch, R S Rossi, J A C Lourenção, C Meira
Administration of progesterone (P4) after estradiol is usually performed to prepare non-cyclic mares as embryo recipients. However, there are successful pregnancy reports after embryo transfer in non-cyclic mares treated only with progestins. The objective of this study was to evaluate endometrial gene expression and immunostaining for estrogen receptor alpha (ERα), beta (ERβ) and progesterone receptor (PR) in seasonal anestrous mares treated with long acting P4 (LA P4). Endometrial tissue from eight seasonal anestrous mares was collected immediately before administration of 1...
December 2, 2017: Theriogenology
https://www.readbyqxmd.com/read/29222540/validation-study-of-the-american-joint-committee-on-cancer-eighth-edition-prognostic-stage-compared-with-the-anatomic-stage-in-breast-cancer
#15
Anna Weiss, Mariana Chavez-MacGregor, Daphne Y Lichtensztajn, Min Yi, Audree Tadros, Gabriel N Hortobagyi, Sharon H Giordano, Kelly K Hunt, Elizabeth A Mittendorf
Importance: The American Joint Committee on Cancer (AJCC) eighth edition staging manual introduced a new prognostic stage for breast cancer incorporating biologic factors in addition to traditional anatomic factors. Objective: To perform a validation study of the AJCC eighth edition prognostic stage in a single-institution cohort and a large population database. Design, Setting, and Participants: Patients with breast cancer treated with surgery as an initial intervention were identified in a prospective institutional database from The University of Texas MD Anderson Cancer Center and the California Cancer Registry...
December 7, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/29222346/adiposity-inflammation-and-breast-cancer-pathogenesis-in-asian-women
#16
Neil M Iyengar, I-Chun Chen, Xi K Zhou, Dilip D Giri, Domenick J Falcone, Lisle A Winston, Hanhan Wang, Samantha Williams, Yen-Shen Lu, Tsu-Hsin Hsueh, Ann-Lii Cheng, Clifford A Hudis, Ching-Hung Lin, Andrew J Dannenberg
Obesity is associated with white adipose tissue (WAT) inflammation in the breast, elevated levels of the estrogen biosynthetic enzyme, aromatase, and systemic changes that predispose to breast cancer development. We examined whether WAT inflammation and its associated systemic effects correlate with body fat levels in an Asian population where body mass index (BMI) is not an accurate assessment of obesity and cancer risk. We also investigated whether biologic differences could account for the greater proportion of premenopausal estrogen receptor (ER)-positive breast cancer in Asian versus western countries...
December 8, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/29220789/new-estrogen-receptor-antagonists-3-20-dihydroxy-19-norpregna-1-3-5-10-trienes-synthesis-molecular-modeling-and-biological-evaluation
#17
Yury V Kuznetsov, Inna S Levina, Alexander M Scherbakov, Olga E Andreeva, Irina V Fedyushkina, Andrey S Dmitrenok, Alexander S Shashkov, Igor V Zavarzin
New estrogen receptor α (ERα) antagonists - 3,20-dihydroxy-19-norpregna-1,3,5(10)-trienes containing an additional carbocyclic ring D' at the 16α,17α positions - were synthesized. The effects of the new compounds on the MCF-7 breast cancer cells and ERα activation were investigated. All the steroids studied were synthesized starting from estrone methyl ether. The scaffold of compounds containing the six-membered ring D' was constructed via the Diels-Alder reaction of butadiene with 3-methoxy-19-norpregna-1,3,5(10),16-tetraen-20-one 5...
November 26, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29219225/dce-mri-texture-analysis-with-tumor-subregion-partitioning-for-predicting-ki-67-status-of-estrogen-receptor-positive-breast-cancers
#18
Ming Fan, Hu Cheng, Peng Zhang, Xin Gao, Juan Zhang, Guoliang Shao, Lihua Li
BACKGROUND: Breast tumor heterogeneity is related to risk factors that lead to worse prognosis, yet such heterogeneity has not been well studied. PURPOSE: To predict the Ki-67 status of estrogen receptor (ER)-positive breast cancer patients via analysis of tumor heterogeneity with subgroup identification based on patterns of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). STUDY TYPE: Retrospective study. POPULATION: Seventy-seven breast cancer patients with ER-positive breast cancer were investigated, of whom 51 had low Ki-67 expression...
December 8, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29218931/-research-progress-in-phytoestrogens-of-traditional-chinese-medicine
#19
REVIEW
Yuan Zhao, Hong-Xia Zheng, Ying Xu, Na Lin
Phytoestrogens are plant-derived compounds, which have a similarity in structure with human endogenous estrogen 17-β-estradiol. Structural likeness enables phytoestrogens to interact with estrogen receptors, not simply mimicking the effects of human steroidal estrogen but also exhibiting similar and divergent actions. The global literature relating to phytoestrogen in recent years was systematically summarized in this paper. Chemical compositions of phytoestrogens were mainly flavonoids, coumarins, lignans, terpenoids, steroids, etc...
September 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29218520/design-synthesis-and-evaluation-of-glut-inhibitors
#20
Carlotta Granchi, Tiziano Tuccinardi, Filippo Minutolo
The Warburg effect describes how most cancer cells exhibit higher-than-normal glucose consumption, not only under hypoxic conditions, but also when normal oxygen levels are present. Although glucose transporter 1 (GLUT1) has been found to play a key role in the cellular uptake of glucose, especially in cancer cells, where it is generally overexpressed, it has not been given consideration as a suitable target for the development of anticancer drugs. In this chapter, an example of molecular design and realization of novel GLUT1 inhibitors, including in silico modeling, chemical synthesis, and biological characterization, is provided...
2018: Methods in Molecular Biology
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