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https://www.readbyqxmd.com/read/29161781/in-silico-docking-studies-of-lupeol-with-mapk-pathway-proteins-raf-1-mek-erk
#1
Mital H Bhatt, Chirag K Prajapati, M N Reddy
Lupeol, A triterpenoid found in variety of plants is reported to have beneficial medicinal effects on several ailments. Lupeol is also found to show inhibitory effect on proliferation of breast cancer cells. Metastasis is considered to be a major cause for worldwide deaths related to cancer. Ras related MAPK Signaling Pathway is one of the crucial pathways leading to metastasis. Lupeols binding possibility with Ras is already reported. In present study, Interaction between with downstream proteins of Ras- MAPK pathway, Raf ,MEK ,ERK1/2 and their corresponding domains are studied using STRING Database and their structures are retrieved in PDB Format...
November 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/29161697/age-period-cohort-modeling-of-multiple-sclerosis-incidence-rates-in-kuwait-1980-2014
#2
Saeed Akhtar, Jarrah Al-Abkal, Jasem Y Al-Hashel, Raed Alroughani
BACKGROUND: Multiple sclerosis (MS) is a complex immune-mediated disorder of the central nervous system with undefined etiology. Genetic predisposition and environmental factors play an imperative role in MS causation and its sustained increasing burden worldwide. This study examined the age, period, and cohort effects on MS incidence rates in Kuwait. METHODS: In this retrospective cohort study, data on MS cases diagnosed between January 1, 1980 and December 31, 2014 and registered in National MS Registry and reference population were obtained...
November 21, 2017: Neuroepidemiology
https://www.readbyqxmd.com/read/29161096/the-role-of-healthcare-technology-management-in-facilitating-medical-device-cybersecurity
#3
Mike Busdicker, Priyanka Upendra
This article discusses the role of healthcare technology management (HTM) in medical device cybersecurity and outlines concepts that are applicable to HTM professionals at a healthcare delivery organization or at an integrated delivery network, regardless of size. It provides direction for HTM professionals who are unfamiliar with the security aspects of managing healthcare technologies but are familiar with standards from The Joint Commission (TJC). It provides a useful set of recommendations, including relevant references for incorporating good security practices into HTM practice...
September 2, 2017: Biomedical Instrumentation & Technology
https://www.readbyqxmd.com/read/29160923/pregnancy-weight-gain-by-gestational-age-and-stillbirth-a-population-based-cohort-study
#4
Kari Johansson, Jennifer A Hutcheon, Lisa M Bodnar, Sven Cnattingius, Olof Stephansson
OBJECTIVE: To study the association between total and early pregnancy (<22 completed weeks) weight gain and risk of stillbirth, stratified by early-pregnancy body mass index (BMI). DESIGN: Population-based cohort study. SETTING: Stockholm-Gotland Region, Sweden. POPULATION: Pregnant women with singleton births (n=160,560). METHODS: Pregnancy weight gain was standardized into gestational age-specific z-scores...
November 21, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29160474/validation-of-family-management-measure-for-the-brazilian-culture
#5
Regina Szylit Bousso, Carolliny Rossi de Faria Ichikawa, Maira Deguer Misko, Maiara Rodrigues Dos Santos, Michelle Freire Baliza, Ana Márcia Chiaradia Mendes-Castillo, Estela Regina Ferraz Bianchi
ETJECTIVE: To validate the Family Management Measure (FaMM) for Brazilian culture. METHOD: Quantitative research excerpt, following the recommendations for validation studies. The data presented refer to the last stage of the process. RESULTS: The internal consistency of the items was analyzed through Cronbach's alpha of the six domains: Child's Daily Life (0.78); Condition Management Effort (0.51); Condition Management Ability (0.55); Family Life Difficulty (0...
November 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29160456/infrastructure-of-pharmacies-of-the-primary-health-care-in-the-brazilian-unified-health-system-analysis-of-pnaum-services-data
#6
Silvana Nair Leite, Fernanda Manzini, Juliana Álvares, Augusto Afonso Guerra, Ediná Alves Costa, Francisco de Assis Acurcio, Ione Aquemi Guibu, Karen Sarmento Costa, Margô Gomes de Oliveira Karnikowski, Orlando Mário Soeiro, Mareni Rocha Farias
OBJECTIVE: To characterize the infrastructure of the primary health care pharmacies of the Brazilian Unified Health System, aiming at humanizing the offered services. METHODS: This is a cross-sectional study, of quantitative approach, from data obtained in the Pesquisa Nacional de Acesso, Utilização e Promoção do Uso Racional de Medicamentos - Serviços, 2015 (PNAUM - National Survey on Access, Use and Promotion of Rational Use of Medicines - Services, 2015)...
November 13, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29160301/new-insights-into-the-pharmacogenomics-of-antidepressant-response-from-the-gendep-and-star-d-studies-rare-variant-analysis-and-high-density-imputation
#7
C Fabbri, K E Tansey, R H Perlis, J Hauser, N Henigsberg, W Maier, O Mors, A Placentino, M Rietschel, D Souery, G Breen, C Curtis, L Sang-Hyuk, S Newhouse, H Patel, M Guipponi, N Perroud, G Bondolfi, M O'Donovan, G Lewis, J M Biernacka, R M Weinshilboum, A Farmer, K J Aitchison, I Craig, P McGuffin, R Uher, C M Lewis
Genome-wide association studies have generally failed to identify polymorphisms associated with antidepressant response. Possible reasons include limited coverage of genetic variants that this study tried to address by exome genotyping and dense imputation. A meta-analysis of Genome-Based Therapeutic Drugs for Depression (GENDEP) and Sequenced Treatment Alternatives to Relieve Depression (STAR*D) studies was performed at the single-nucleotide polymorphism (SNP), gene and pathway levels. Coverage of genetic variants was increased compared with previous studies by adding exome genotypes to previously available genome-wide data and using the Haplotype Reference Consortium panel for imputation...
November 21, 2017: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/29160163/cancer-risk-associated-with-nuclear-atypia-in-cytologically-indeterminate-thyroid-nodules-a-systematic-review-and-meta-analysis
#8
Pablo Valderrabano, Laila Khazai, Zachary J Thompson, Susan C Sharpe, Valentina D Tarasova, Kristen J Otto, Julie E Hallanger-Johnson, J Trad Wadsworth, Bruce M Wenig, Christine H Chung, Barbara A Centeno, Bryan McIver
BACKGROUND: Indeterminate categories of thyroid cytopathology (categories B-III and B-IV of the Bethesda system) are integrated by a heterogeneous spectrum of cytological scenarios that are generally clustered for analysis and management recommendations. It has been suggested that aspirates exhibiting nuclear atypia have a higher risk of malignancy. We assess whether cytologically indeterminate thyroid nodules with nuclear atypia have a significantly higher cancer risk than those without nuclear atypia...
November 21, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29159857/methylphenidate-for-children-and-adolescents-with-autism-spectrum-disorder
#9
REVIEW
Nancy Sturman, Laura Deckx, Mieke L van Driel
BACKGROUND: Children with autistic spectrum disorder (ASD) frequently present with inattention, impulsivity and hyperactivity, which are the cardinal symptoms of attention deficit hyperactivity disorder (ADHD). The effectiveness of methylphenidate, a commonly used ADHD treatment, is therefore of interest in these children. OBJECTIVES: To assess the effects of methylphenidate for symptoms of ADHD (inattention, impulsivity and hyperactivity) and ASD (impairments in social interaction and communication, and repetitive, restricted or stereotypical behaviours) in children and adolescents aged 6 to 18 years with ASD...
November 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29159855/b1-artifact-reduction-in-abdominal-dce-mri-using-kt-points-first-clinical-assessment-of-dynamic-rf-shimming-at-3t
#10
Raphaël Tomi-Tricot, Vincent Gras, Franck Mauconduit, François Legou, Nicolas Boulant, Matthias Gebhardt, Dieter Ritter, Berthold Kiefer, Pierre Zerbib, Alain Rahmouni, Alexandre Vignaud, Alain Luciani, Alexis Amadon
BACKGROUND: The excitation inhomogeneity artifact occurring at 3T in the abdomen can lead to dramatic loss of signal and contrast, thereby hampering diagnosis. PURPOSE: To assess excitation homogeneity and image quality achieved by nonselective prototypical kT -points pulses, compared to tailored static RF shimming, in clinical routine on a commercial dual-transmit scanner. STUDY TYPE: Retrospective study with Institutional Review Board approval; informed consent was waived...
November 21, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29159773/japan-society-of-gynecologic-oncology-guidelines-2015-for-the-treatment-of-vulvar-cancer-and-vaginal-cancer
#11
Toshiaki Saito, Tsutomu Tabata, Hitoshi Ikushima, Hiroyuki Yanai, Hironori Tashiro, Hitoshi Niikura, Takeo Minaguchi, Toshinari Muramatsu, Tsukasa Baba, Wataru Yamagami, Kazuya Ariyoshi, Kimio Ushijima, Mikio Mikami, Satoru Nagase, Masanori Kaneuchi, Nobuo Yaegashi, Yasuhiro Udagawa, Hidetaka Katabuchi
BACKGROUND: Vulvar cancer and vaginal cancer are relatively rare tumors, and there had been no established treatment principles or guidelines to treat these rare tumors in Japan. The first version of the Japan Society of Gynecologic Oncology (JSGO) guidelines for the treatment of vulvar cancer and vaginal cancer was published in 2015 in Japanese. OBJECTIVE: The JSGO committee decided to publish the English version of the JSGO guidelines worldwide, and hope it will be a useful guide to physicians in a similar situation as in Japan...
November 20, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29159696/reflex-testing-of-speckled-cytoplasmic-patterns-observed-in-routine-ana-hep-2-indirect-immunofluorescence-with-a-multiplex-anti-synthetase-dot-blot-assay-a-multicentric-pilot-study
#12
Maria Infantino, Boaz Palterer, Roberta Biagiotti, Fabio Almerigogna, Maurizio Benucci, Arianna Damiani, Valentina Grossi, Annalisa Azzurri, Patrizia Casprini, Giovanni Bacci, Maria Grazia Giudizi, Mariangela Manfredi
Immunofluorescence on HEp2-cells is the standard diagnostic assay for the detection of anti-nuclear antibodies (ANA). Cytoplasmic speckled patterns are a common finding, and are associated with various antibodies, including anti-synthetase antibodies. However, classic ENA testing generally identifies only anti-Jo-1. Moreover, anti-synthetase syndrome is increasingly recognized as a pleomorphic entity, possibly presenting as isolated arthritis or interstitial lung disease. Sera referred for routine ANA testing were selected on the basis of the presence of a fine dense speckled cytoplasmic pattern (254 samples) and compared to control sera with negative cytoplasm (239 samples)...
November 21, 2017: Immunologic Research
https://www.readbyqxmd.com/read/29159573/low-baseline-and-subsequent-higher-aortic-abdominal-aneurysm-fdg-uptake-are-associated-with-poor-sac-shrinkage-post-endovascular-repair
#13
Pierre-Yves Marie, Didier Plissonnier, Stéphanie Bravetti, Raphael Coscas, Martin Rouer, Stéphan Haulon, Damien Mandry, Jean-Marc Alsac, Sergueï Malikov, Nicla Settembre, Yann Gouëffic, Olivier Morel, Véronique Roch, Emilien Micard, Zohra Lamiral, Jean-Baptiste Michel, Patrick Rossignol
PURPOSE: The growth phases of medically treated abdominal aortic aneurysms (AAA) are frequently associated with an (18)F-fluorodesoxyglucose positron emission tomography (FDG-PET) pattern involving low baseline and subsequent higher FDG uptake. However, the FDG-PET patterns associated with the endovascular aneurysm repair (EVAR) of larger AAA are presently unknown. This study aimed to investigate the relationship between serial AAA FDG uptake measurements, obtained before EVAR and 1 and 6 months post-intervention and subsequent sac shrinkage at 6 months, a well-recognized indicator of successful repair...
November 21, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29159371/care-planning-for-inpatients-referred-for-palliative-care-consultation
#14
Kara Bischoff, David L O'Riordan, Angela K Marks, Rebecca Sudore, Steven Z Pantilat
Importance: Care planning is a critical function of palliative care teams, but the impact of advance care planning and goals of care discussions by palliative care teams has not been well characterized. Objective: To describe the population of patients referred to inpatient palliative care consultation teams for care planning, the needs identified by palliative care clinicians, the care planning activities that occur, and the results of these activities. Design, Setting, and Participants: This was a prospective cohort study conducted between January 1, 2013, and December 31, 2016...
November 20, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29158623/criterion-validity-of-the-hrqolisp-e-a-new-context-specific-screening-tool-for-poststroke-depression
#15
Akin Ojagbemi, Mayowa Owolabi, Joshua Akinyemi, Bruce Ovbiagele
Objectives: The optimal tool for identifying postsroke depression (PSD) is yet to be identified. In the present study, we rely on the depression subscale of the Hospital Anxiety and Depression Scale (HADS-D) as a meaningful criterion to investigate the psychometric properties of the HRQOLISP-E, a new context-specific screening tool for PSD developed from a large cross-cultural sample. Methods: We assessed baseline data being collected as part of an intervention to improve one-year blood pressure control among recent (≤one month) stroke survivors...
2017: Behavioural Neurology
https://www.readbyqxmd.com/read/29158536/validation-of-methods-for-prediction-of-clinical-output-levels-of-active-middle-ear-implants-from-measurements-in-human-cadaveric-ears
#16
Martin Grossöhmichen, Bernd Waldmann, Rolf Salcher, Nils Prenzler, Thomas Lenarz, Hannes Maier
Today, the standard method to predict output levels of active middle ear implants (AMEIs) before clinical data are available is stapes vibration measurement in human cadaveric ears, according to ASTM standard F2504-05. Although this procedure is well established, the validity of the predicted output levels has never been demonstrated clinically. Furthermore, this procedure requires a mobile and visually accessible stapes and an AMEI stimulating the ossicular chain. Thus, an alternative method is needed to quantify the output level of AMEIs in all other stimulation modes, e...
November 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29158354/confirmatory-tests-for-the-diagnosis-of-primary-aldosteronism-a-prospective-diagnostic-accuracy-study
#17
Ying Song, Shumin Yang, Wenwen He, Jinbo Hu, Qingfeng Cheng, Yue Wang, Ting Luo, Linqiang Ma, Qianna Zhen, Suhua Zhang, Mei Mei, Zhihong Wang, Hua Qing, Dennis Bruemmer, Bin Peng, Qifu Li
The diagnosis of primary aldosteronism typically requires at least one confirmatory test. The fludrocortisone suppression test is generally accepted as a reliable confirmatory test, but it is cumbersome. Evidence from accuracy studies of the saline infusion test (SIT) and the captopril challenge test (CCT) has provided conflicting results. This prospective study aimed to evaluate the diagnostic accuracy of the SIT and CCT using fludrocortisone suppression test as the reference standard. One hundred thirty-five patients diagnosed with primary aldosteronism and 101 patients diagnosed with essential hypertension who completed the 3 confirmatory tests were included for the diagnostic accuracy analysis...
November 20, 2017: Hypertension
https://www.readbyqxmd.com/read/29158246/self-taken-vaginal-swabs-versus-clinician-taken-for-detection-of-candida-and-bacterial-vaginosis-a-case-control-study-in-primary-care
#18
Pam Barnes, Rute Vieira, Jayne Harwood, Mayur Chauhan
BACKGROUND: Vaginal discharge and vulvitis are common presenting symptoms in general practice. Few studies have specifically looked at the validity of self-taken low vulvovaginal swabs (LVS) for the diagnosis of vulvovaginal candidiasis (VVC) and bacterial vaginosis (BV). AIM: To assess if patient self-taken LVS are a valid alternative to clinician-taken high vaginal swabs (HVS) for the detection of VVC and BV. DESIGN AND SETTING: Case-control study with the patient acting as their own control in an urban sexual health centre in Newcastle upon Tyne, UK...
November 20, 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/29158143/urinary-concentration-and-antimicrobial-activity-of-tobramycin-in-healthy-volunteers-receiving-a-single-oral-dose-of-a-novel-formulation-for-improved-absorption
#19
Maria Loose, Kurt G Naber, Paul Shields, Harald Reinhart, Florian M E Wagenlehner
BACKGROUND: Oral antibiotics for the treatment of UTI are scarce. In this ex vivo phase 1 annex study, clinical safety, urinary concentrations and bactericidal activity of a new formulation for improved oral absorption of tobramycin (Tobrate(TM)) were evaluated. METHODS: The minimal inhibitory and bactericidal concentrations (MIC/MBC) of five test strains, one reference strain and four clinical uropathogenic strains, were determined in cation-adjusted Mueller-Hinton Broth (CAMHB) and in pooled antimicrobial agent-free urine of the subjects at different pH (5...
November 17, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29158042/development-of-an-inhalation-reference-concentration-for-diethanolamine
#20
Joseph T Haney, Darrell McCant, Michael E Honeycutt, Sabine Lange
An inhalation reference concentration (RfC) was developed for diethanolamine (DEA), based principally on evaluation of three animal studies (Gamer et al., 1993, 1996, 2008). The RfC (25 μg/m(3)) was based on statistically significantly increased relative liver weight in female rats in Gamer et al. (2008) as the critical effect. The lower confidence limit on the benchmark dose (BMDL10 of 5.5 mg/m(3)) was adjusted to a human equivalent concentration and to continuous exposure before dividing the final point of departure (2...
November 17, 2017: Regulatory Toxicology and Pharmacology: RTP
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