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https://www.readbyqxmd.com/read/29786410/percutaneous-deep-venous-arterialization-in-patients-with-critical-limb-ischemia-a-technical-note
#1
Steven Kum, Eline Huizing, Michiel A Schreve, Çagdas Ünlü, Roberto Ferraresi, Lasitha B Samarakoon, Daniel A van den Heuvel
Critical limb ischemia (CLI) is the presentation of end stage peripheral arterial disease and typically presents with rest pain, ulceration and gangrene. The outcome of conservative treatment is poor and often leads to amputations. Arterial revascularization plays an important role in amputation prevention. Unfortunately, a significant percentage of CLI patients cannot be revascularized and subsequently end up with a palliative amputation. This has led to the need and exploration of new treatment options in this no option subgroup of CLI...
May 22, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29785797/relationship-between-handgrip-strength-and-pulmonary-function-in-apparently-healthy-older-women
#2
Da-Hye Son, Ji-Won Yoo, Mi-Ra Cho, Yong-Jae Lee
OBJECTIVES: To investigate the relationship between handgrip strength and pulmonary function. DESIGN: Cross-sectional study of a representative sample of older Korean women. SETTING: The Korean National Health and Nutrition Examination Survey. PARTICIPANTS: Community-dwelling women aged 65 and older without chronic diseases or pulmonary disease (N=605). MEASUREMENTS: Handgrip strength was measured using a digital hand dynamometer, and pulmonary function was tested according to guidelines of the American Thoracic Society/European Respiratory Society using a spirometry system...
May 21, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29785727/body-composition-profiling-in-the-uk-biobank-imaging-study
#3
Jennifer Linge, Magnus Borga, Janne West, Theresa Tuthill, Melissa R Miller, Alexandra Dumitriu, E Louise Thomas, Thobias Romu, Patrik Tunón, Jimmy D Bell, Olof Dahlqvist Leinhard
OBJECTIVE: This study aimed to investigate the value of imaging-based multivariable body composition profiling by describing its association with coronary heart disease (CHD), type 2 diabetes (T2D), and metabolic health on individual and population levels. METHODS: The first 6,021 participants scanned by UK Biobank were included. Body composition profiles (BCPs) were calculated, including abdominal subcutaneous adipose tissue, visceral adipose tissue (VAT), thigh muscle volume, liver fat, and muscle fat infiltration (MFI), determined using magnetic resonance imaging...
May 22, 2018: Obesity
https://www.readbyqxmd.com/read/29785359/white-matter-microstructure-white-matter-lesions-and-hypertension-an-examination-of-early-surrogate-markers-of-vascular-related-brain-change-in-midlife
#4
Thaddeus Haight, R Nick Bryan, Guray Erus, Meng-Kang Hsieh, Christos Davatzikos, Ilya Nasrallah, Mark D'Esposito, David R Jacobs, Cora Lewis, Pamela Schreiner, Stephen Sidney, Osorio Meirelles, Lenore J Launer
Objective: We examined imaging surrogates of white matter microstructural abnormalities which may precede white matter lesions (WML) and represent a relevant marker of cerebrovascular injury in adults in midlife. Methods: In 698 community-dwelling adults (mean age 50 years ±3.5 SD) from the Coronary Artery Risk Development in Young Adults (CARDIA) Brain MRI sub-study, WML were identified on structural MR and fractional anisotropy (FA), representing WM microstructural integrity, was derived using Diffusion Tensor Imaging...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29784607/telestroke-adoption-among-community-hospitals-in-north-carolina-a-cross-sectional-study
#5
Christopher M Shea, Amir Alishahi Tabriz, Kea Turner, Steve North, Kristin L Reiter
OBJECTIVE: This study identifies community and hospital characteristics associated with adoption of telestroke among acute care hospitals in North Carolina (NC). METHODS: Our sample included 107 hospitals located in NC. Our analytic dataset included variables from the American Hospital Association (AHA) annual survey, AHA Health IT supplement, Healthcare Cost Report Information System, and Centers for Disease Control and Prevention's WONDER online database. We supplemented our secondary sources with data on telestroke adoption and market-level variables developed for NC...
May 18, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29782463/gut-microbiota-probiotics-and-sport-from-clinical-evidence-to-agonistic-performance
#6
Marco Pane, Angela Amoruso, Francesca Deidda, Teresa Graziano, Serena Allesina, Luca Mogna
Human beings harbor clusters of bacteria in different parts of the body, such as the surface or the deep layers of the skin, the mouth, the lungs, the intestine, the vagina, and all the surfaces exposed to the outer world. The majority of microbes resides in the gut, have a weighty influence on human physiology and nutrition and are vital for human life. There is growing evidence showing that the gut microbiota plays important roles in the maturation of the immune system and the protection against some infectious agents...
May 18, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29782406/population-pharmacokinetics-and-pharmacodynamics-of-dexmedetomidine-in-children-undergoing-ambulatory-surgery
#7
María-Gabriela Pérez-Guillé, Alejandra Toledo-López, Liliana Rivera-Espinosa, Radames Alemon-Medina, Chiharu Murata, Ismael Lares-Asseff, Juan Luis Chávez-Pacheco, Josefina Gómez-Garduño, Ana-Lilia Zamora Gutiérrez, Claudia Orozco-Galicia, Karina Ramírez-Morales, Gustavo Lugo-Goytia
BACKGROUND: Dexmedetomidine (DEX) is an α-2 adrenergic agonist with sedative and analgesic properties. Although not approved for pediatric use by the Food and Drug Administration, DEX is increasingly used in pediatric anesthesia and critical care. However, very limited information is available regarding the pharmacokinetics of DEX in children. The aim of this study was to investigate DEX pharmacokinetics and pharmacodynamics (PK-PD) in Mexican children 2-18 years of age who were undergoing outpatient surgical procedures...
May 17, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29781383/preferential-spinal-cord-volume-loss-in-primary-progressive-multiple-sclerosis
#8
Charidimos Tsagkas, Stefano Magon, Laura Gaetano, Simon Pezold, Yvonne Naegelin, Michael Amann, Christoph Stippich, Philippe Cattin, Jens Wuerfel, Oliver Bieri, Till Sprenger, Ludwig Kappos, Katrin Parmar
BACKGROUND: Little is known on longer term changes of spinal cord volume (SCV) in primary progressive multiple sclerosis (PPMS). OBJECTIVE: Longitudinal evaluation of SCV loss in PPMS and its correlation to clinical outcomes, compared to relapse-onset multiple sclerosis (MS) subtypes. METHODS: A total of 60 MS age-, sex- and disease duration-matched patients (12 PPMS, each 24 relapsing-remitting (RRMS) and secondary progressive MS (SPMS)) were analysed annually over 6 years of follow-up...
May 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29780417/osteoporosis-is-associated-with-deteriorating-clinical-status-in-adults-with-cystic-fibrosis
#9
Inger Hee Mathiesen, Tacjana Pressler, Peter Oturai, Terese Lea Katzenstein, Marianne Skov, Ruth Frikke-Schmidt, Mette Friberg Hitz
Background: Cystic fibrosis (CF) patients are in increased risk of osteoporosis. We aimed to determine the osteoporosis prevalence in an adult CF cohort and investigate calcium metabolic parameters and clinical status' association with bone mineral density evaluated by dual X-ray absorptiometry scan. Methods: We performed a cross section database study of adults at a tertiary CF Center. Z scores were applied for patients < 50 years of age and T scores for patients > 50 years of age...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29780351/cerebral-blood-flow-changes-in-multiple-sclerosis-and-neuromyelitis-optica-and-their-correlations-with-clinical-disability
#10
Xue Zhang, Xi Guo, Ningnannan Zhang, Huanhuan Cai, Jie Sun, Qiuhui Wang, Yuan Qi, Linjie Zhang, Li Yang, Fu-Dong Shi, Chunshui Yu
Distinguishing relapsing-remitting multiple sclerosis (RRMS) and neuromyelitis optica (NMO) is clinically important because they differ in prognosis and treatment. This study aimed to identify perfusion abnormalities in RRMS and NMO and their correlations with gray matter volume (GMV) atrophy and clinical parameters. Structural and arterial spin labeling MRI scans were performed in 39 RRMS patients, 62 NMO patients, and 73 healthy controls. The gray matter cerebral blood flow (CBF) values were voxel-wisely compared among the three groups with and without GMV correction...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29779936/early-response-assessment-on-mid-treatment-computed-tomography-predicts-for-locoregional-recurrence-in-oropharyngeal-cancer-patients-treated-with-definitive-radiation-therapy
#11
Rafi Kabarriti, N Patrik Brodin, George Lundgren, Nitin Ohri, Wolfgang A Tomé, Shalom Kalnicki, Madhur K Garg
PURPOSE: To evaluate whether a response assessment using mid-treatment computed tomography (CT) scans during definitive radiation therapy (RT) for oropharyngeal head and neck cancer can predict for locoregional recurrence (LRR). METHODS AND MATERIALS: Head and neck cancer patients who receive RT at our institution undergo CT repeat scans at the 15th fraction, with treatment replanning in the case of an inadequate dose to gross disease or an increased dose to organs at risk...
April 6, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29779815/use-of-standard-enteral-formula-versus-enteric-formula-with-prebiotic-content-in-nutrition-therapy-a-randomized-controlled-study-among-neuro-critical-care-patients
#12
Piril Tuncay, Fatma Arpaci, Mutlu Doganay, Deniz Erdem, Arzu Sahna, Hulya Ergun, Dilek Atabey
OBJECTIVE: To compare use of standard enteral formula versus enteric formula with prebiotic content in terms of nutrition therapy related outcomes among neurocritical care patients. METHODS: A total of 46 adult neurocritical care patients who received nutrition therapy with standard enteral formula (SEF group; n = 23) or enteral formula with prebiotic content (EFPC group; n = 23) during their hospitalization in intensive care unit (ICU) were included in this prospective randomized controlled study...
June 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29779759/correlation-of-human-papilloma-virus-status-with-quantitative-perfusion-diffusion-metabolic-imaging-parameters-in-the-oral-cavity-and-oropharyngeal-squamous-cell-carcinoma-comparison-of-primary-tumour-sites-and-metastatic-lymph-nodes
#13
M Han, S J Lee, D Lee, S Y Kim, J W Choi
AIM: To investigate the differences in perfusion/diffusion/metabolic imaging parameters according to human papilloma virus (HPV) status in the oral cavity and oropharyngeal squamous cell carcinoma (OC-OPSCC), separately in primary tumour sites and metastatic lymph nodes. MATERIALS AND METHODS: This retrospective study comprised 41 patients with primary OC-OPSCCs and 29 patients with metastatic lymph nodes. The perfusion/diffusion/metabolic imaging parameters were measured at the primary tumour and the largest ipsilateral metastatic lymph node...
May 17, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29777963/red-wolf-canis-rufus-sperm-quality-and-quantity-is-affected-by-semen-collection-method-extender-components-and-post-thaw-holding-temperature
#14
Ashley D Franklin, William T Waddell, Karen L Goodrowe
Cryopreserving genetic resources is becoming increasingly important for species management. In the zoo-based red wolf (Canis rufus) population, inbreeding continues to increase in the absence of new founders. Through banking sperm, we preserve genetic diversity and create the ability to decrease inbreeding accumulation in the future. The quality and quantity of banked sperm can be affected by cryopreservation media and semen collection methods. This study's objectives were to further optimize semen extender used for red wolf sperm cryopreservation, investigate effects of post-thaw holding temperature, and to determine if urethral catheterization is an effective method for semen collection in this species...
May 16, 2018: Theriogenology
https://www.readbyqxmd.com/read/29775699/relationship-between-intraprostatic-urethral-sphincter-status-and-prostate-volume-as-revealed-by-magnetic-resonance-imaging
#15
Fumiyasu Endo, Kazuhiro Ohwaki, Masaki Shimbo, Kazunori Hattori
OBJECTIVES: To evaluate the relationship between the lengths of two regions of the intraprostatic urethral sphincter, the distal region (from the apex to the adenoma; AA) and the proximal region (from the adenoma to the verumontanum; AV) and prostate volume (PV) in patients with clinical benign prostate hyperplasia. METHODS: A total of 110 patients who underwent magnetic resonance imaging (MRI) prior to holmium laser enucleation of the prostate were enrolled. The lengths of two distinct intraprostatic urethral regions were measured on MRI, and we used multiple regression analysis to explore the association between these lengths and PV...
May 15, 2018: Urology
https://www.readbyqxmd.com/read/29774747/hypertonic-saline-versus-isotonic-saline-nasal-irrigation-systematic-review-and-meta-analysis
#16
Dichapong Kanjanawasee, Kachorn Seresirikachorn, Wirach Chitsuthipakorn, Kornkiat Snidvongs
Background Saline nasal lavage is one of the treatments of sinonasal diseases. Evidence from basic research favors hypertonic saline (HS) over isotonic saline (IS) for mucociliary clearance, but evidence from clinical studies is controversial. Conversely, HS may carry greater side effects. Objective To compare the effects of HS and IS nasal irrigation in treating sinonasal diseases. Methods Systematic search with Ovid MEDLINE, Scopus, PubMed, Google Scholar, and Manual additional sources was conducted. Randomized controlled trials comparing HS with IS nasal irrigation in treating any sinonasal diseases, including rhinitis and rhinosinusitis, were included...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29774396/tumor-volume-as-a-prognostic-marker-in-p16-positive-and-p16-negative-oropharyngeal-cancer-patients-treated-with-definitive-intensity-modulated-radiotherapy
#17
Timo Carpén, Kauko Saarilahti, Caj Haglund, Antti Markkola, Jussi Tarkkanen, Jaana Hagström, Petri Mattila, Antti Mäkitie
PURPOSE: To investigate the impact of primary gross tumor volume (pGTV) and nodal gross tumor volume (nGTV) in oropharyngeal squamous cell carcinoma (OPSCC) and the difference in their role between human papillomavirus (HPV)-positive and HPV-negative patients. METHODS: The patient cohort consists of 91 OPSCC patients treated with definitive radiochemotherapy or radiotherapy using intensity-modulated radiotherapy (IMRT). All patients had a minimum follow-up of 31 months...
May 17, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29773492/what-is-the-hospital-volume-threshold-to-optimize-inpatient-complication-rate-after-partial-nephrectomy
#18
Sohrab Arora, Jacob Keeley, Daniel Pucheril, Mani Menon, Craig G Rogers
OBJECTIVE: To find a cutoff of hospital volume for elective partial nephrectomy (PN) for kidney cancer that can minimize the inpatient morbidity of this procedure. MATERIAL AND METHODS: Analyzing the National Inpatient sample, from 2008 to 2011, we selected 8,753 records of adult patients undergoing elective PN for nonmetastatic kidney cancer, representing an estimated 43,178 partial nephrectomies performed in the United States during this period. Of these, 2,187 (estimated 10,848) PNs were performed via the robotic approach...
May 14, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29770706/intestinal-transplants-review-of-normal-imaging-appearance-and-complications
#19
Bashir Hakim, Daniel T Myers, Todd R Williams, Shunji Nagai, John Bonnett
Intestinal transplant (IT) is one of the least common forms of organ transplant but is increasing both in volume of cases and number of centers performing intestinal transplants, with the busiest centers in North America and Europe. IT can be performed in isolation or as part of a multivisceral transplant (MVT). Intestinal failure either in the form of short gut syndrome or functional bowel problems is the primary indication for IT. The normal post-surgical anatomy can be variable due to both recipient anatomy in regard to amount of residual bowel and status of native vasculature as well as whether the transplant is isolated or part of an multivisceral transplant...
May 17, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29770314/factors-leading-to-pancreatic-resection-in-patients-with-pancreatic-cancer-a-national-perspective
#20
David T Pointer, Zaid Al-Qurayshi, John B Hamner, Douglas P Slakey, Emad Kandil
Background: Resection is the only option for potential cure in pancreatic cancer. Patients admitted for resection may have the procedure deferred during their hospitalization. We aim to identify factors that lead pancreatic cancer patients to undergo resection. Methods: An analysis utilizing the Nationwide Inpatient Sample (NIS) database, 2003-2009. Study population included adults (≥18 years) with pancreatic cancer who underwent either pancreatic resection or other interventions...
April 2018: Gland Surgery
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