Zhicong Zhao, Xia Deng, Jue Jia, Li Zhao, Chenxi Wang, Zhensheng Cai, Chang Guo, Ling Yang, Dong Wang, Suxian Ma, Jialiang Deng, Haoxiang Li, Libin Zhou, Zhigang Tu, Guoyue Yuan
BACKGROUND & AIMS: Angiopoietin-like protein 8 (ANGPTL8) is a 198 amino-acid long, novel secreted protein that is mainly expressed in the liver and brown adipose tissues. At present, evidence supporting the involvement of ANGPTL8 in the regulation of glucose metabolism is inconclusive, along with its function in the liver. Previous studies mainly focused on the effect of ANGPTL8 on glucose metabolism in non-diabetic mice, and few relevant studies in diabetic mice exist. Therefore, this study aimed to investigate the role of ANGPTL8 on glucose homeostasis and elucidate the underlying mechanisms in diabetic mice...
January 2022: Metabolism: Clinical and Experimental