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Betatrophin

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https://www.readbyqxmd.com/read/28081192/circulating-betatrophin-levels-and-gestational-diabetes-mellitus-a-systematic-review-and-meta-analysis
#1
Fei-Juan Kong, Lei-Lei Ma, Ge Li, Yi-Xin Chen, Jia-Qiang Zhou
OBJECTIVE: The association between circulating betatrophin levels and gestational diabetes mellitus (GDM) is controversial. The aim of our study was to systematically review available literature linking betatrophin to GDM for a comprehensive understanding of the relationship between circulating betatrophin levels and GDM in human. METHODS: PubMed, The Cochrane Library, Medline and CNKI were searched for studies published up to August 2016. Manual searches of references of the relevant original studies were conducted...
2017: PloS One
https://www.readbyqxmd.com/read/28074664/recent-advances-in-molecular-biomarkers-for-diabetes-mellitus-a-systematic-review
#2
Ty Lees, Najah Nassif, Ann Simpson, Fatima Shad-Kaneez, Rose Martiniello-Wilks, Yiguang Lin, Allan Jones, Xianqin Qu, Sara Lal
CONTEXT: Diabetes is a growing global metabolic epidemic. Current research is focusing on exploring how the biological processes and clinical outcomes of diabetes are related and developing novel biomarkers to measure these relationships, as this can subsequently improve diagnostic, therapeutic and management capacity. OBJECTIVE: To identify the most recent advances in molecular biomarkers of diabetes and directions that warrant further research. METHODS: Using a systematic search strategy, the MEDLINE, CINAHL and OVID MEDLINE databases were canvassed for articles that investigated molecular biomarkers for diabetes...
January 11, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28038792/retraction-notice-to-betatrophin-a-hormone-that-controls-pancreatic-%C3%AE-cell-proliferation
#3
Peng Yi, Ji-Sun Park, Douglas A Melton
No abstract text is available yet for this article.
January 12, 2017: Cell
https://www.readbyqxmd.com/read/27982676/lipasin-betatrophin-is-differentially-expressed-in-liver-and-white-adipose-tissue-without-association-with-insulin-resistance-in-wistar-and-goto-kakizaki-rats
#4
M Cahová, D Habart, T Olejár, Z Berková, Z Papáčková, H Daňková, A Lodererova, M Heczková, F Saudek
Lipasin is a recently identified lipokine expressed predominantly in liver and in adipose tissue. It was linked to insulin resistance in mice and to type 1 and type 2 diabetes (T1D, T2D) in humans. No metabolic studies concerning lipasin were performed yet in rats. Therefore, we used rat model of T2D and insulin resistance, Goto-Kakizaki (GK) rats, to determine changes of lipasin expression in liver and in white adipose tissue (WAT) over 52 weeks in the relation to glucose tolerance, peripheral tissue insulin sensitivity and adiposity...
December 16, 2016: Physiological Research
https://www.readbyqxmd.com/read/27960599/association-of-betatrophin-with-metabolic-characteristics-in-overweight-obese-and-lean-women-with-pcos
#5
Linxia Li, Feng Zhang, Jingjing Cui, Yu Shi, Jiangdong Xiang, Xuejiao Wang, Naisi Zhao, Qingwu Yan, Andrew S Greenberg, Yongde Peng, Xiaoying Ding
As a new hormone, betatrophin has gained attention as a potential new target to combat insulin resistance (IR) and diabetes. Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder among women of the reproductive age with long term sequelae which include IR and metabolic syndrome. The aim of this study is to evaluate the circulating plasma betatrophin levels in overweight/obese or lean women with or without PCOS and also to elucidate possible correlations with anthropometric and metabolic parameters...
December 14, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27919710/the-transcription-factor-carbohydrate-response-element-binding-protein-chrebp-a-possible-link-between-metabolic-disease-and-cancer
#6
REVIEW
Katsumi Iizuka
Carbohydrate-response element-binding protein (ChREBP) has been identified as a transcription factor that binds to carbohydrate response element in the promoter of pyruvate kinase, liver and red blood cells. ChREBP is activated by metabolites derived from glucose and suppressed by adenosine monophosphate (AMP), ketone bodies and cyclic cAMP. ChREBP regulates gene transcription related to glucose and lipid metabolism. Findings from knockout mice and human subjects suggest that ChREBP helps to induce hepatic steatosis, dyslipidemia, and glucose intolerance...
February 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27752839/levels-of-metabolic-markers-in-drug-naive-prediabetic-and-type-2-diabetic-patients
#7
Amal Akour, Violet Kasabri, Nailya Boulatova, Yasser Bustanji, Randa Naffa, Dana Hyasat, Nahla Khawaja, Haidar Bustanji, Ayman Zayed, Munther Momani
AIMS: Type 2 diabetes mellitus (T2DM) and prediabetes (pre-DM) are associated with changes in levels of metabolic markers. The main aim of this study is to compare the levels of omentin, irisin, endothelin-1, nesfatin, hepatocyte growth factor (HGF), fibroblast growth factor, and oxytocin (OXT) between normoglycemic and pre-DM/T2DM obese Jordanian patients. METHODS: One hundred and ninety-eight adult Jordanian subjects were recruited. Demographic data and clinical parameters were collected...
October 18, 2016: Acta Diabetologica
https://www.readbyqxmd.com/read/27733177/increased-angptl3-4-and-angptl8-betatrophin-expression-levels-in-obesity-and-t2d
#8
Mohamed Abu-Farha, Irina Al-Khairi, Preethi Cherian, Betty Chandy, Devarajan Sriraman, Asma Alhubail, Faisal Al-Refaei, Abdulmohsen AlTerki, Jehad Abubaker
BACKGROUND: Hypertriglyceridemia is associated with increased risk for cardiovascular diseases and type 2 diabetes (T2D). Angiopoietin like proteins particularly 3, 4 and recently 8 are well established regulators of plasma triglyceride level through regulating the activity of lipoprotein lipase. Plasma level and association between ANGPTL3, 4 and 8 is not well established in human subjects. This study was designed to establish the level of these proteins in plasma and adipose tissues and investigate the association between ANGPTL8 with ANGPTL3 and 4 in T2D and non-diabetics subjects...
October 13, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27716289/vitamin-d-modifies-the-associations-between-circulating-betatrophin-and-cardiometabolic-risk-factors-among-youths-at-risk-for-metabolic-syndrome
#9
Junling Fu, Cong Hou, Lujiao Li, Dan Feng, Ge Li, Mingyao Li, Changhong Li, Shan Gao, Ming Li
BACKGROUND: Betatrophin has been recently reported to play a role in glucose homeostasis by inducing beta-cell proliferation in mice. However, studies in human are inconsistent. As a nutritionally-regulated liver-enriched factor, we hypothesize that betatrophin might be regulated by vitamin D, and ignorance of vitamin D status may explain the discrepancy in previous human studies. The aims of this study were to assess the association between circulating betatrophin and glucose homeostasis as well as other cardiometabolic variables in a cohort of youths at risk for metabolic syndrome and test the possible influence of vitamin D status on the association...
October 6, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27690684/novel-adipokines-wisp1-and-betatrophin-in-pcos-relationship-to-amh-levels-atherogenic-and-metabolic-profile
#10
Gulcin Sahin Ersoy, Tugba Altun Ensari, Dogan Vatansever, Volkan Emirdar, Ozge Cevik
OBJECTIVE: To determine the levels of WISP1 and betatrophin in normal weight and obese women with polycystic ovary syndrome (PCOS) and to assess their relationship with anti-Müllerian hormone (AMH) levels, atherogenic profile and metabolic parameters Methods: In this prospective cross-sectional study, the study group was composed of 49 normal weighed and 34 obese women with PCOS diagnosed based on the Rotterdam criteria; 36 normal weight and 26 obese age matched non-hyperandrogenemic women with regular menstrual cycle...
September 30, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27672665/the-rise-and-the-fall-of-betatrophin-angptl8-as-an-inducer-of-%C3%AE-cell-proliferation
#11
Mohamed Abu-Farha, Ashraf Al Madhoun, Jehad Abubaker
Diabetes is a global health problem that is caused by impaired insulin production from pancreatic β-cells. Efforts to regenerate β-cells have been advancing rapidly in the past two decades with progress made towards identifying new agents that induce β-cells regeneration. ANGPTL8, also named betatrophin, has been recently identified as a hormone capable of inducing β-cells proliferation and increasing β-cells mass in rodents. Its discovery has been cherished as a breakthrough and a game changer in the field of β-cells regeneration...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27640796/-elevated-serum-levels-of-betatrophin-in-patients-with-polycystic-ovary-syndrome-and-the-influential-factors
#12
Shumin Song, Jia Wang, Chenghui Guo, Tiejian Jiang
OBJECTIVE: To determine serum levels of betatrophin in patients with polycystic ovary syndrome (PCOS) and the influential factors. 
 METHODS: A total of 100 PCOS patients were enrolled randomly as a PCOS group, and 40 age-matched healthy women were recruited as a normal control (NC) group. Primary clinical or biochemical parameters of the subjects were detected. The results were analyzed by SPSS 19.0.
 RESULTS: Serum betatrophin levels were elevated in the PCOS group compared with the NC group...
September 28, 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/27578619/the-correlation-between-plasma-levels-of-oxytocin-and-betatrophin-in-non-diabetic-and-diabetic-metabolic-syndrome-patients-a-cross-sectional-study-from-jordan
#13
Amani Al-Rawashdeh, Violet Kasabri, Nailya Bulatova, Amal Akour, Ayman Zayed, Munther Momani, Nahla Khawaja, Haider Bustanji, Dana Hyasat
BACKGROUND: Oxytocin (OXT) is a neurohypophyseal hormone that has been recently shown to possess a number of beneficial effects in diabetes and obesity. Betatrophin is a protein expressed in fat and liver that regulates lipid metabolism and promotes pancreatic β-cell proliferation. It is not investigated yet whether OXT and betatrophin levels correlate in metabolic syndrome (MS) or diabetes patients. METHODS: The aim was to assess correlations between plasma betatrophin and OXT levels in MS-diabetic or prediabetic (N=89) as compared to MS-non-diabetic (N=69) patients...
August 22, 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/27555469/levels-of-betatrophin-decrease-during-pregnancy-despite-increased-insulin-resistance-beta-cell-function-and-triglyceride-levels
#14
A Zielińska, R Maciulewski, K Siewko, A Popławska-Kita, D Lipińska, G Kozłowska, M Górska, M Szelachowska
AIM: Evidence in support of an association between betatrophin and insulin resistance (IR) is mounting, with studies demonstrating that betatrophin is elevated in patients with type 2 diabetes, obesity and gestational diabetes. The aim of this study was to evaluate the role of betatrophin in IR and physiological proliferation of beta cells during pregnancy in healthy women. METHODS: Eighty healthy pregnant women were examined at each trimester [T1 (first), T2 (second), T3 (third)], with a subgroup (n=45) that was also examined at 3 months postpartum (3MPP)...
December 2016: Diabetes & Metabolism
https://www.readbyqxmd.com/read/27554132/relationship-between-serum-betatrophin-levels-and-the-first-phase-of-glucose-stimulated-insulin-secretion
#15
Dan Liu, Hua Qu, Hang Wang, Yang Duan, Fang Liu, Zhengping Feng, Huacong Deng
AIMS: To examine circulating betatrophin concentrations in subjects with different glucose tolerance status and to investigate the relationship between serum betatrophin levels and first-phase of glucose-stimulated insulin secretion. METHODS: Serum betatrophin concentrations were measured in 110 age- and sex-matched subjects: 47 newly diagnosed type 2 diabetes mellitus (T2DM), 29 impaired glucose tolerance (IGT) and 34 normal glucose tolerance (NGT). Oral glucose tolerance test and intravenous glucose tolerance test were performed to assess glucose tolerance and first-phase of glucose-stimulated insulin secretion...
August 20, 2016: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/27472196/altered-concentrations-in-dyslipidemia-evidence-a-role-for-angptl8-betatrophin-in-lipid-metabolism-in-humans
#16
Javier Gómez-Ambrosi, Eider Pascual-Corrales, Victoria Catalán, Amaia Rodríguez, Beatriz Ramírez, Sonia Romero, Neus Vila, Patricia Ibáñez, María A Margall, Camilo Silva, María J Gil, Javier Salvador, Gema Frühbeck
CONTEXT: Angiopoietin-like protein 8 (ANGPTL8)/betatrophin is a secreted protein initially involved in β-cell replication. Recent data in humans and mice models suggest that ANGPTL8/betatrophin is more related to lipid metabolism. OBJECTIVE: The aim of the present study was to compare the circulating concentrations of ANGPTL8/betatrophin in individuals with dyslipidemia defined as having high or low levels of high-density lipoprotein (HDL)-cholesterol or triglycerides, respectively...
October 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27459526/weight-loss-partially-restores-glucose-driven-betatrophin-response-in-humans
#17
Lukas Maurer, Sebastian Brachs, Anne-Marie Decker, Maria Brachs, Verena Leupelt, Reiner Jumpertz von Schwartzenberg, Andrea Ernert, Thomas Bobbert, Heiko Krude, Joachim Spranger, Knut Mai
CONTEXT: Recently a potential role of betatrophin was shown in the postprandial switch from lipid to glucose metabolism. OBJECTIVE: To analyse whether obesity is associated with altered postprandial betatrophin response and whether this could be restored by weight loss. Design, Setting, Participants, Intervention: Oral glucose load was performed in 12 lean individuals at baseline as well as in 20 obese subjects before and after a 12-week structured weight loss program at an endocrinology research center...
July 26, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27410263/resolving-discrepant-findings-on-angptl8-in-%C3%AE-cell-proliferation-a-collaborative-approach-to-resolving-the-betatrophin-controversy
#18
Aaron R Cox, Ornella Barrandon, Erica P Cai, Jacqueline S Rios, Julia Chavez, Claire W Bonnyman, Carol J Lam, Peng Yi, Douglas A Melton, Jake A Kushner
The β-cell mitogenic effects of ANGPTL8 have been subjected to substantial debate. The original findings suggested that ANGPTL8 overexpression in mice induced a 17-fold increase in β-cell proliferation. Subsequent studies in mice contested this claim, but a more recent report in rats supported the original observations. These conflicting results might be explained by variable ANGPTL8 expression and differing methods of β-cell quantification. To resolve the controversy, three independent labs collaborated on a blinded study to test the effects of ANGPTL8 upon β-cell proliferation...
2016: PloS One
https://www.readbyqxmd.com/read/27402552/betatrophin-no-relation-to-glucose-metabolism-or-weight-status-in-obese-children-before-and-after-lifestyle-intervention
#19
Christian L Roth, Clinton Elfers, Nina Lass, Thomas Reinehr
OBJECTIVE: The influences of obesity, glucose metabolism, gender, and puberty on betatrophin levels and the longitudinal relationships between weight loss, metabolic changes and betatrophin have not yet been studied in childhood. METHODS: Cross-sectional and longitudinal analysis of weight status (standard deviation score-body mass index (SDS-BMI)), homeostasis model assessment insulin resistance (HOMA-IR), gender, and pubertal stage were evaluated in 69 obese children (51% female, age 11...
July 12, 2016: Pediatric Diabetes
https://www.readbyqxmd.com/read/27399923/betatrophin-levels-were-increased-in-pregnant-women-with-or-without-gestational-diabetes-mellitus-and-associated-with-beta-cell-function
#20
Yun Huang, Chen Fang, Zhimin Ma, Heming Guo, Ruihua Wang, Ji Hu
Purpose betatrophin has been reported to boost β cell expansion in insulin resistant states. Pregnancy is a well-recognized physiological state of insulin resistance. Betatrophin levels in pregnant women and their relationships with metabolic variables remain to be elucidated. Methods A total of 49 pregnant women and 31 age-matched unpregnant women with normal glucose regulation (UP-NGR) were included. Among these subjects, according to results from 75 g oral glucose tolerance test (OGTT), 22 women were diagnosed as having gestational diabetes mellitus (GDM)...
June 2016: Revista Brasileira de Ginecologia e Obstetrícia
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