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Betatrophin

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https://www.readbyqxmd.com/read/29365962/betatrophin-a-new-insight-into-lipid-homeostasis
#1
Eva Bace, Michal Karpisek, David Stejskal, Hana Kotolova, Viktor Ruzicka, Martina Hlozankova
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29363048/association-of-serum-betatrophin-with-fibroblast-growth-factor-21-in-women-with-polycystic-ovary-syndrome
#2
S Kahraman, A E Altinova, M M Yalcin, O Gulbahar, B Arslan, M Akturk, N Cakir, F B Toruner
PURPOSE: Betatrophin and fibroblast growth factor-21 (FGF-21), which are recently discovered members of hepatokine/adipokine family, have been proposed to be associated with some metabolic disorders in which insulin resistance plays a major role. METHODS: We aimed to investigate serum betatrophin and FGF-21 concentrations in women with polycystic ovary syndrome (PCOS). In this cross-sectional study, we recruited 31 women with PCOS and 34 women as healthy controls...
January 23, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29228555/circulating-betatrophin-is-associated-with-insulin-resistance-in-humans-cross-sectional-and-interventional-studies-in-vivo-and-in-vitro
#3
Han Wang, Lin Du, Tong Wu, Gangyi Yang, Wenjing Hu, Hansheng Wang, Mengliu Yang, Dongfang Liu, Harvest F Gu, Zhiming Zhu, Hongting Zheng, Ling Li
Betatrophin has a closely relationship with metabolism. However, its effect on metabolism disorder remains unclear. This study was comprised of a series of cross-sectional and interventional studies in vivo and vitro. PCOS women with IR and healthy women were recruited from the general population and outpatients. Plasma betatrophin levels were measured with ELISA. Insulin sensitivity was assessed with EHC. Gene expressions at mRNA and protein levels were determined with RT-PCR and Western blotting. Influences of insulin, metformin, rosiglitazone and over- or knockdown-expression of betatrophin were analyzed ex vivo...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29199405/serum-betatrophin-concentrations-and-the-risk-of-incident-diabetes-a-nested-case-control-study-from-chungju-metabolic-disease-cohort
#4
Seung Hwan Lee, Marie Rhee, Hyuk Sang Kwon, Yong Moon Park, Kun Ho Yoon
BACKGROUND: Betatrophin is a newly identified hormone derived from the liver and adipose tissue, which has been suggested to regulate glucose and lipid metabolism. Circulating levels of betatrophin are altered in various metabolic diseases, although the results are inconsistent. We aimed to examine whether betatrophin is a useful biomarker in predicting the development of diabetes. METHODS: A nested case-control study was performed using a prospective Chungju Metabolic disease Cohort Study...
November 3, 2017: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/28931172/the-correlation-between-circulating-betatrophin-and-insulin-resistance-in-general-population-a-meta-analysis
#5
Jinling Xu, Yanyan Lin, Hui Zhou, Linshuang Zhao, Guangda Xiang
Many inconsistent findings are reported on the correlation between circulating betatrophin and insulin resistance in the different population. The aim of this analysis was to explore the correlation between the level of betatrophin and insulin resistance in the general population. The databases of PubMed, EMBASE, and the Cochrane Library (inception to October 26, 2016) were searched without language restrictions for publications that reported studies on associations between betatrophin and insulin resistance in adults...
October 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28849903/chemical-protein-synthesis-with-the-%C3%AE-ketoacid-hydroxylamine-ligation
#6
Jeffrey W Bode
The coupling of an α-ketoacid and a hydroxylamine (KAHA ligation) affords amide bonds under aqueous, acidic conditions without the need for protecting groups or coupling agents. Translating this finding into a general approach to chemical protein synthesis required the identification of methods to incorporate the key functional groups into unprotected peptide segments-ideally using well-established Fmoc solid-phase peptide synthesis protocols. A decade of effort has now led to robust, convenient methods for preparing peptides bearing free or masked C-terminal α-ketoacids and N-terminal hydroxylamines...
August 29, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28811856/serum-betatrophin-levels-and-clinical-features-in-patients-with-poorly-controlled-type-2-diabetes
#7
Kohzo Takebayashi, Kenji Hara, Tomoko Terasawa, Rika Naruse, Mariko Suetsugu, Takafumi Tsuchiya, Toshihiko Inukai
BACKGROUND: Betatrophin is a hormone mainly secreted by the liver that influences lipid metabolisms. The main purposes of this study were to investigate the effect of canagliflozin (a sodium glucose transporter 2 inhibitor) on circulating betatrophin levels, and to investigate the correlation of various markers associated with glucose and lipid metabolisms with betatrophin in patients with poorly controlled type 2 diabetes. METHODS: Patients were randomly divided into a control group (n = 15) and a canagliflozin-treated group (n = 15)...
September 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28722798/angptl8-betatrophin-role-in-diabetes-and-metabolic-diseases
#8
REVIEW
Mohamed Abu-Farha, Jehad Abubaker, Jaakko Tuomilehto
Diabetes is a major disease worldwide that is reaching epidemic levels. Its increased prevalence as well as its association with a high number of complications such as cardiovascular diseases, nephropathy, and retinopathy makes it an important disease for investigation. ANGPTL8 is a recently identified hormone that has been associated with two functionally important processes in the development of type 2 diabetes, insulin resistance as well as lipid metabolism. Initial work has shown that ANGPTL8 was expressed in liver, white adipose, and brown adipose tissues...
November 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28717133/insulin-upregulates-betatrophin-expression-via-pi3k-akt-pathway
#9
Puhan Lu, Xi Chen, Zeqing Zhang, Jianhua Zhang, Yan Yang, Zhelong Liu, Junhui Xie, Shiying Shao, Xinrong Zhou, Shuhong Hu, Wentao He, Jiajun Zhao, Xuefeng Yu
Betatrophin is regarded as a liver-produced hormone induced by insulin resistance (IR). However, it remains largely unknown how IR regulates betatrophin expression. To study whether IR could regulate betatrophin expression and the corresponding molecular mechanisms, betatrophin levels were examined in 6 in vitro IR models which were established using human hepatocytes L02 with different agents, including tumor necrosis factor-α, interleukin-1β, dexamethasone, palmitate, high glucose and insulin and betatrophin levels were elevated only in the insulin group...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28702052/serum-concentrations-of-betatrophin-and-its-association-with-indirect-indices-of-insulin-resistance-and-beta-cell-function-in-women-with-polycystic-ovary-syndrome
#10
Agnieszka Adamska, Agnieszka Łebkowska, Małgorzata Jacewicz, Anna Krentowska, Justyna Hryniewicka, Sławomir Wołczyński, Maria Górska, Irina Kowalska
INTRODUCTION: Data underline the role of betatrophin in glucose homeostasis. Polycystic ovary syndrome (PCOS) is characterized by insulin resistance (IR). The aim of our study was to investigate the relationship of serum betatrophin concentrations with indirect indices of IR and insulin secretion in women with PCOS, compared to the control group. METHODS: The study group comprised 43 women with PCOS and 16 controls. IR was assessed by HOMA-IR and Matsuda index. Insulin secretion was evaluated with HOMA-B...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28446155/erratum-to-higher-serum-betatrophin-level-in-type-2-diabetes-subjects-is-associated-with-urinary-albumin-excretion-and-renal-function
#11
Chang-Chiang Chen, Hendra Susanto, Wen-Han Chuang, Ta-Yu Liu, Arivajiagane Arundhathi, Chih-Hong Wang
No abstract text is available yet for this article.
April 26, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28428942/follicular-fluid-cerebellin-and-betatrophin-regulate-the-metabolic-functions-of-growing-follicles-in-polycystic-ovary-syndrome
#12
Aynur Adeviye Ersahin, Mustafa Acet, Suat Suphan Ersahin, Tuba Acet, Meltem Yardim, Omer Kenanoglu, Suleyman Aydin
OBJECTIVE: The aim of this study was to assess the changes of follicular fluid (FF) and serum levels of cerebellin precursor protein 1 (cbln1) and betatrophin in patients with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) with a gonadotropin-releasing hormone (GnRH) antagonist protocol. METHODS: Twenty infertile women with PCOS and 20 control women diagnosed as poor responders undergoing ovarian stimulation with a GnRH antagonist were included...
March 2017: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/28351093/angptl8-betatrophin-is-expressed-in-visceral-adipose-tissue-and-relates-to-human-hepatic-steatosis-in-two-independent-clinical-collectives
#13
Christian von Loeffelholz, Andreas F H Pfeiffer, Johan F Lock, Steffi Lieske, Stephanie Döcke, Veronica Murahovschi, Jennifer Kriebel, Tonia de Las Heras Gala, Harald Grallert, Natalia Rudovich, Martin Stockmann, Joachim Spranger, Gerhard Jahreis, Stefan R Bornstein, George Lau, Aimin Xu, Jeanette Schulz-Menger, Louisa Exner, Sven Haufe, Jens Jordan, Stefan Engeli, Andreas L Birkenfeld
Angiopoietin-like protein 8 (ANGPTL8)/betatrophin expression in visceral adipose tissue and associations with circulating fatty acid profile have not yet been investigated.Forty subjects were included in a cross-sectional study, 57 in a dietary weight reduction intervention. Circulating Angiopoietin-like protein 8/betatrophin was measured in all subjects. Liver and adipose tissue were sampled and plasma fatty acids and tissue Angiopoietin-like protein 8/betatrophin expression were evaluated in the cross-sectional study...
May 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28351091/plasma-betatrophin-levels-of-subjects-classified-with-normal-impaired-and-diabetic-glucose-tolerance-and-subjects-with-impaired-fasting-glucose
#14
Sibel Ozyazgan, Burak Onal, Eda Merve Kurtulus, Hafize Uzun, Gokhan Akkan, Dildar Konukoglu
This study was aimed to investigate whether betatrophin shows glucose intolerance or not. To access the plasma betatrophin levels after basal and glucose load, groups were classified as normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and diabetic glucose tolerance (DGT) according to WHO 2012 criteria. An oral glucose tolerance test was performed on age-matched subjects (n=220) with a body mass index (BMI)<27 kg/m 2 . Subjects were categorized as normoglycemic (n=55), IFG (n=50), IGT (n=60), and DM (n=55) according to the WHO criteria...
June 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28319674/assessment-of-circulating-betatrophin-concentrations-in-lean-glucose-tolerant-women-with-polycystic-ovary-syndrome
#15
Onur Erol, Mustafa Kemal Özel, Hamit Yaşar Ellidağ, Tayfun Toptaş, Aysel Uysal Derbent, Necat Yılmaz
The aims of the current study were to investigate the betatrophin levels in lean glucose-tolerant women with polycystic ovary syndrome (PCOS), and to explore the relationships between these levels and antropometric, hormonal and metabolic parameters. The study population consisted of 50 lean (body mass index [BMI] < 25 kg/m(2)) women diagnosed with PCOS using the Rotterdam criteria, and 60 age- and BMI-matched healthy controls without any features of clinical or biochemical hyperandrogenism. Before recruitment, glucose tolerance was evaluated in all of the subjects using the 2-h 75 g oral glucose-tolerance test, and only those exhibiting normal glucose tolerance were enrolled...
March 20, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28290605/transplantation-of-betatrophin-expressing-adipose-derived-mesenchymal-stem-cells-induces-%C3%AE-cell-proliferation-in-diabetic-mice
#16
Liang-Liang Sun, Tian-Jin Liu, Limei Li, Wei Tang, Jun-Jie Zou, Xiang-Fang Chen, Jiao-Yang Zheng, Bei-Ge Jiang, Yong-Quan Shi
Recent progress in regenerative medicine has suggested that mesenchymal stem cell (MSC)-based therapy is a novel potential cure for diabetes. Betatrophin is a newly identified hormone that can increase the production and expansion of insulin-secreting β-cells when administered to mice. In this study, we evaluated the effect of betatrophin overexpression by human adipose-derived MSCs (ADMSCs) by in vitro experiments, as well as following their transplantation into a mice with streptozotocin (STZ)-induced diabetes...
April 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28265415/metabolic-improvements-following-roux-en-y-surgery-assessed-by-solid-meal-test-in-subjects-with-short-duration-type-2-diabetes
#17
Sudha S Shankar, Lori A Mixson, Manu Chakravarthy, Robin Chisholm, Anthony J Acton, RoseMarie Jones, Samer G Mattar, Deborah L Miller, Lea Petry, Chan R Beals, S Aubrey Stoch, David E Kelley, Robert V Considine
BACKGROUND: Glucose homeostasis improves within days following Roux-en-Y gastric bypass (RYGB) surgery. The dynamic metabolic response to caloric intake following RYGB has been assessed using liquid mixed meal tolerance tests (MMTT). Few studies have evaluated the glycemic and hormonal response to a solid mixed meal in subjects with diabetes prior to, and within the first month following RYGB. METHODS: Seventeen women with type 2 diabetes of less than 5 years duration participated...
2017: BMC Obesity
https://www.readbyqxmd.com/read/28257453/renal-function-is-independently-associated-with-circulating-betatrophin
#18
Lukas Maurer, Franziska Schwarz, Antje Fischer-Rosinsky, Nina Schlueter, Sebastian Brachs, Matthias Möhlig, Andreas Pfeiffer, Knut Mai, Joachim Spranger, Thomas Bobbert
OBJECTIVE: Betatrophin has been identified as a marker linking liver with beta cell function and lipid metabolism in murine models. Until now, the regulation of circulating betatrophin in humans is not entirely clear. We here analyzed the relation of betatrophin levels to phenotypes of the metabolic syndrome and speculated that renal function might influence circulating betatrophin levels and explain age-dependent changes of betatrophin. SUBJECTS: We analyzed blood samples from 535 individuals participating in the Metabolic Syndrome Berlin Potsdam study...
2017: PloS One
https://www.readbyqxmd.com/read/28222635/serum-betatrophin-levels-are-increased-and-associated-with-insulin-resistance-in-patients-with-polycystic-ovary-syndrome
#19
Qinglan Qu, Dongmei Zhao, Fengrong Zhang, Hongchu Bao, Qiuhua Yang
Objective Betatrophin is a newly identified circulating protein that is significantly associated with type 2 diabetes mellitus (T2DM), adiposity, and metabolic syndrome. The aim of this study was to investigate whether betatrophin levels and polycystic ovary syndrome (PCOS) were associated. Methods Circulating betatrophin levels were measured in 162 patients with PCOS and 156 matched control females using specific enzyme-linked immunosorbent assay kits. Correlations between betatrophin levels and PCOS incidence as well as multiple key endocrine PCOS parameters were analyzed using multiple statistical methods...
February 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28196120/correction-circulating-betatrophin-levels-and-gestational-diabetes-mellitus-a-systematic-review-and-meta-analysis
#20
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pone.0169941.].
2017: PloS One
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