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Betatrophin

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https://www.readbyqxmd.com/read/28319674/assessment-of-circulating-betatrophin-concentrations-in-lean-glucose-tolerant-women-with-polycystic-ovary-syndrome
#1
Onur Erol, Mustafa Kemal Özel, Hamit Yaşar Ellidağ, Tayfun Toptaş, Aysel Uysal Derbent, Necat Yılmaz
The aims of the current study were to investigate the betatrophin levels in lean glucose-tolerant women with polycystic ovary syndrome (PCOS), and to explore the relationships between these levels and antropometric, hormonal and metabolic parameters. The study population consisted of 50 lean (body mass index [BMI] < 25 kg/m(2)) women diagnosed with PCOS using the Rotterdam criteria, and 60 age- and BMI-matched healthy controls without any features of clinical or biochemical hyperandrogenism. Before recruitment, glucose tolerance was evaluated in all of the subjects using the 2-h 75 g oral glucose-tolerance test, and only those exhibiting normal glucose tolerance were enrolled...
March 20, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28290605/transplantation-of-betatrophin-expressing-adipose-derived-mesenchymal-stem-cells-induces-%C3%AE-cell-proliferation-in-diabetic-mice
#2
Liang-Liang Sun, Tian-Jin Liu, Limei Li, Wei Tang, Jun-Jie Zou, Xiang-Fang Chen, Jiao-Yang Zheng, Bei-Ge Jiang, Yong-Quan Shi
Recent progress in regenerative medicine has suggested that mesenchymal stem cell (MSC)-based therapy is a novel potential cure for diabetes. Betatrophin is a newly identified hormone that can increase the production and expansion of insulin-secreting β-cells when administered to mice. In this study, we evaluated the effect of betatrophin overexpression by human adipose-derived MSCs (ADMSCs) by in vitro experiments, as well as following their transplantation into a mice with streptozotocin (STZ)-induced diabetes...
March 10, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28265415/metabolic-improvements-following-roux-en-y-surgery-assessed-by-solid-meal-test-in-subjects-with-short-duration-type-2-diabetes
#3
Sudha S Shankar, Lori A Mixson, Manu Chakravarthy, Robin Chisholm, Anthony J Acton, RoseMarie Jones, Samer G Mattar, Deborah L Miller, Lea Petry, Chan R Beals, S Aubrey Stoch, David E Kelley, Robert V Considine
BACKGROUND: Glucose homeostasis improves within days following Roux-en-Y gastric bypass (RYGB) surgery. The dynamic metabolic response to caloric intake following RYGB has been assessed using liquid mixed meal tolerance tests (MMTT). Few studies have evaluated the glycemic and hormonal response to a solid mixed meal in subjects with diabetes prior to, and within the first month following RYGB. METHODS: Seventeen women with type 2 diabetes of less than 5 years duration participated...
2017: BMC Obesity
https://www.readbyqxmd.com/read/28257453/renal-function-is-independently-associated-with-circulating-betatrophin
#4
Lukas Maurer, Franziska Schwarz, Antje Fischer-Rosinsky, Nina Schlueter, Sebastian Brachs, Matthias Möhlig, Andreas Pfeiffer, Knut Mai, Joachim Spranger, Thomas Bobbert
OBJECTIVE: Betatrophin has been identified as a marker linking liver with beta cell function and lipid metabolism in murine models. Until now, the regulation of circulating betatrophin in humans is not entirely clear. We here analyzed the relation of betatrophin levels to phenotypes of the metabolic syndrome and speculated that renal function might influence circulating betatrophin levels and explain age-dependent changes of betatrophin. SUBJECTS: We analyzed blood samples from 535 individuals participating in the Metabolic Syndrome Berlin Potsdam study...
2017: PloS One
https://www.readbyqxmd.com/read/28222635/serum-betatrophin-levels-are-increased-and-associated-with-insulin-resistance-in-patients-with-polycystic-ovary-syndrome
#5
Qinglan Qu, Dongmei Zhao, Fengrong Zhang, Hongchu Bao, Qiuhua Yang
Objective Betatrophin is a newly identified circulating protein that is significantly associated with type 2 diabetes mellitus (T2DM), adiposity, and metabolic syndrome. The aim of this study was to investigate whether betatrophin levels and polycystic ovary syndrome (PCOS) were associated. Methods Circulating betatrophin levels were measured in 162 patients with PCOS and 156 matched control females using specific enzyme-linked immunosorbent assay kits. Correlations between betatrophin levels and PCOS incidence as well as multiple key endocrine PCOS parameters were analyzed using multiple statistical methods...
February 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28196120/correction-circulating-betatrophin-levels-and-gestational-diabetes-mellitus-a-systematic-review-and-meta-analysis
#6
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pone.0169941.].
2017: PloS One
https://www.readbyqxmd.com/read/28177922/increased-circulating-full-length-betatrophin-levels-in-drug-na%C3%A3-ve-metabolic-syndrome
#7
Dan Liu, Sheyu Li, He He, Chuan Yu, Xiaodan Li, Libo Liang, Yi Chen, Jianwei Li, Jianshu Li, Xin Sun, Haoming Tian, Zhenmei An
Betatrophin is a newly identified circulating adipokine playing a role in the regulation of glucose homeostasis and lipid metabolism. But its role in metabolic syndrome (MetS) remains unknown. Therefore, we aimed to compare the circulating betatrophin concentrations between patients with MetS and healthy controls. We recruited 47 patients with MetS and 47 age and sex matched healthy controls. Anthropometric and biochemical measurements were performed, and serum betatrophin levels were detected by ELISA. Full-length betatrophin levels in patients with MetS were significantly higher than those in controls (694...
February 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28125672/relationship-of-serum-betatrophin-with-nonalcoholic-fatty-liver-in-a-chinese-population
#8
Wen Hu, Xiaojuan Shao, Dianxuan Guo, Hairong Hao, Yong Zhang, Mingfeng Xia, Yingyun Gong, Hongwen Zhou, Yunqing Fan, Weinan Yu
OBJECTIVE: This study aimed to investigate the association of serum betatrophin with the status and progression of nonalcoholic fatty liver disease (NAFLD). METHODS: A total of 249 subjects who received ultrasonic examination of liver fat content (LFC) were recruited. Anthropometric and biochemical examinations were performed. Serum betatrophin was measured by ELISA. RESULTS: Compared with control group, serum betatrophin significantly increased in NAFLD group (P < 0...
2017: PloS One
https://www.readbyqxmd.com/read/28081192/circulating-betatrophin-levels-and-gestational-diabetes-mellitus-a-systematic-review-and-meta-analysis
#9
Fei-Juan Kong, Lei-Lei Ma, Ge Li, Yi-Xin Chen, Jia-Qiang Zhou
OBJECTIVE: The association between circulating betatrophin levels and gestational diabetes mellitus (GDM) is controversial. The aim of our study was to systematically review available literature linking betatrophin to GDM for a comprehensive understanding of the relationship between circulating betatrophin levels and GDM in human. METHODS: PubMed, The Cochrane Library, Medline and CNKI were searched for studies published up to August 2016. Manual searches of references of the relevant original studies were conducted...
2017: PloS One
https://www.readbyqxmd.com/read/28074664/recent-advances-in-molecular-biomarkers-for-diabetes-mellitus-a-systematic-review
#10
Ty Lees, Najah Nassif, Ann Simpson, Fatima Shad-Kaneez, Rosetta Martiniello-Wilks, Yiguang Lin, Allan Jones, Xianqin Qu, Sara Lal
CONTEXT: Diabetes is a growing global metabolic epidemic. Current research is focussing on exploring how the biological processes and clinical outcomes of diabetes are related and developing novel biomarkers to measure these relationships, as this can subsequently improve diagnostic, therapeutic and management capacity. OBJECTIVE: The objective of this study is to identify the most recent advances in molecular biomarkers of diabetes and directions that warrant further research...
January 24, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28038792/retraction-notice-to-betatrophin-a-hormone-that-controls-pancreatic-%C3%AE-cell-proliferation
#11
Peng Yi, Ji-Sun Park, Douglas A Melton
No abstract text is available yet for this article.
January 12, 2017: Cell
https://www.readbyqxmd.com/read/27982676/lipasin-betatrophin-is-differentially-expressed-in-liver-and-white-adipose-tissue-without-association-with-insulin-resistance-in-wistar-and-goto-kakizaki-rats
#12
M Cahová, D Habart, T Olejár, Z Berková, Z Papáčková, H Daňková, A Lodererova, M Heczková, F Saudek
Lipasin is a recently identified lipokine expressed predominantly in liver and in adipose tissue. It was linked to insulin resistance in mice and to type 1 and type 2 diabetes (T1D, T2D) in humans. No metabolic studies concerning lipasin were performed yet in rats. Therefore, we used rat model of T2D and insulin resistance, Goto-Kakizaki (GK) rats, to determine changes of lipasin expression in liver and in white adipose tissue (WAT) over 52 weeks in the relation to glucose tolerance, peripheral tissue insulin sensitivity and adiposity...
December 16, 2016: Physiological Research
https://www.readbyqxmd.com/read/27960599/association-of-betatrophin-with-metabolic-characteristics-in-overweight-obese-and-lean-women-with-pcos
#13
Linxia Li, Feng Zhang, Jingjing Cui, Yu Shi, Jiangdong Xiang, Xuejiao Wang, Naisi Zhao, Qingwu Yan, Andrew S Greenberg, Yongde Peng, Xiaoying Ding
As a new hormone, betatrophin has gained attention as a potential new target to combat insulin resistance (IR) and diabetes. Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder among women of the reproductive age with long term sequelae which include IR and metabolic syndrome. The aim of this study is to evaluate the circulating plasma betatrophin levels in overweight/obese or lean women with or without PCOS and also to elucidate possible correlations with anthropometric and metabolic parameters...
December 14, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27919710/the-transcription-factor-carbohydrate-response-element-binding-protein-chrebp-a-possible-link-between-metabolic-disease-and-cancer
#14
REVIEW
Katsumi Iizuka
Carbohydrate-response element-binding protein (ChREBP) has been identified as a transcription factor that binds to carbohydrate response element in the promoter of pyruvate kinase, liver and red blood cells. ChREBP is activated by metabolites derived from glucose and suppressed by adenosine monophosphate (AMP), ketone bodies and cyclic cAMP. ChREBP regulates gene transcription related to glucose and lipid metabolism. Findings from knockout mice and human subjects suggest that ChREBP helps to induce hepatic steatosis, dyslipidemia, and glucose intolerance...
February 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27752839/levels-of-metabolic-markers-in-drug-naive-prediabetic-and-type-2-diabetic-patients
#15
Amal Akour, Violet Kasabri, Nailya Boulatova, Yasser Bustanji, Randa Naffa, Dana Hyasat, Nahla Khawaja, Haidar Bustanji, Ayman Zayed, Munther Momani
AIMS: Type 2 diabetes mellitus (T2DM) and prediabetes (pre-DM) are associated with changes in levels of metabolic markers. The main aim of this study is to compare the levels of omentin, irisin, endothelin-1, nesfatin, hepatocyte growth factor (HGF), fibroblast growth factor, and oxytocin (OXT) between normoglycemic and pre-DM/T2DM obese Jordanian patients. METHODS: One hundred and ninety-eight adult Jordanian subjects were recruited. Demographic data and clinical parameters were collected...
February 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/27733177/increased-angptl3-4-and-angptl8-betatrophin-expression-levels-in-obesity-and-t2d
#16
Mohamed Abu-Farha, Irina Al-Khairi, Preethi Cherian, Betty Chandy, Devarajan Sriraman, Asma Alhubail, Faisal Al-Refaei, Abdulmohsen AlTerki, Jehad Abubaker
BACKGROUND: Hypertriglyceridemia is associated with increased risk for cardiovascular diseases and type 2 diabetes (T2D). Angiopoietin like proteins particularly 3, 4 and recently 8 are well established regulators of plasma triglyceride level through regulating the activity of lipoprotein lipase. Plasma level and association between ANGPTL3, 4 and 8 is not well established in human subjects. This study was designed to establish the level of these proteins in plasma and adipose tissues and investigate the association between ANGPTL8 with ANGPTL3 and 4 in T2D and non-diabetics subjects...
October 13, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27716289/vitamin-d-modifies-the-associations-between-circulating-betatrophin-and-cardiometabolic-risk-factors-among-youths-at-risk-for-metabolic-syndrome
#17
Junling Fu, Cong Hou, Lujiao Li, Dan Feng, Ge Li, Mingyao Li, Changhong Li, Shan Gao, Ming Li
BACKGROUND: Betatrophin has been recently reported to play a role in glucose homeostasis by inducing beta-cell proliferation in mice. However, studies in human are inconsistent. As a nutritionally-regulated liver-enriched factor, we hypothesize that betatrophin might be regulated by vitamin D, and ignorance of vitamin D status may explain the discrepancy in previous human studies. The aims of this study were to assess the association between circulating betatrophin and glucose homeostasis as well as other cardiometabolic variables in a cohort of youths at risk for metabolic syndrome and test the possible influence of vitamin D status on the association...
October 6, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27690684/novel-adipokines-wisp1-and-betatrophin-in-pcos-relationship-to-amh-levels-atherogenic-and-metabolic-profile
#18
Gulcin Sahin Ersoy, Tugba Altun Ensari, Dogan Vatansever, Volkan Emirdar, Ozge Cevik
OBJECTIVE: To determine the levels of WISP1 and betatrophin in normal weight and obese women with polycystic ovary syndrome (PCOS) and to assess their relationship with anti-Müllerian hormone (AMH) levels, atherogenic profile and metabolic parameters Methods: In this prospective cross-sectional study, the study group was composed of 49 normal weighed and 34 obese women with PCOS diagnosed based on the Rotterdam criteria; 36 normal weight and 26 obese age matched non-hyperandrogenemic women with regular menstrual cycle...
February 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27672665/the-rise-and-the-fall-of-betatrophin-angptl8-as-an-inducer-of-%C3%AE-cell-proliferation
#19
Mohamed Abu-Farha, Ashraf Al Madhoun, Jehad Abubaker
Diabetes is a global health problem that is caused by impaired insulin production from pancreatic β-cells. Efforts to regenerate β-cells have been advancing rapidly in the past two decades with progress made towards identifying new agents that induce β-cells regeneration. ANGPTL8, also named betatrophin, has been recently identified as a hormone capable of inducing β-cells proliferation and increasing β-cells mass in rodents. Its discovery has been cherished as a breakthrough and a game changer in the field of β-cells regeneration...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27640796/-elevated-serum-levels-of-betatrophin-in-patients-with-polycystic-ovary-syndrome-and-the-influential-factors
#20
Shumin Song, Jia Wang, Chenghui Guo, Tiejian Jiang
OBJECTIVE: To determine serum levels of betatrophin in patients with polycystic ovary syndrome (PCOS) and the influential factors. 
 METHODS: A total of 100 PCOS patients were enrolled randomly as a PCOS group, and 40 age-matched healthy women were recruited as a normal control (NC) group. Primary clinical or biochemical parameters of the subjects were detected. The results were analyzed by SPSS 19.0.
 RESULTS: Serum betatrophin levels were elevated in the PCOS group compared with the NC group...
September 28, 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
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