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Fisiopathology

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https://www.readbyqxmd.com/read/25476252/in-silico-design-of-beta-secretase-inhibitors-in-alzheimer-s-disease
#1
Evandro Pizeta Semighini
Alzheimer's disease is the major cause of senile dementia, flewing out 10% of 65 years old and 50% of 85 years old global population. The major fisiopathologic characteristics of Alzheimer's disease are the deposition of extracellular neuritic plaques and the presence of intracellular neurofibrillary tangles in memory-related areas of the brain. The plaques are composed by the β-amyloid peptide with 40 or 42 residues, result from hydrolysis of the amyloid precursor protein by the β-secretase 1 (BACE-1) on the amyloidogenic pathway, that begins with the BACE-1 and which inhibition is considered one of the most promising treatments available of Alzheimer's disease...
September 2015: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/24386337/characterization-of-insulin-antibodies-by-surface-plasmon-resonance-in-two-clinical-cases-brittle-diabetes-and-insulin-autoimmune-syndrome
#2
Aldana Trabucchi, Ruben F Iacono, Luciano L Guerra, Natalia I Faccinetti, Andrea G Krochik, María C Arriazu, Edgardo Poskus, Silvina N Valdez
In this study, the characterization of insulin (auto)antibodies has been described, mainly in terms of concentration (q), affinity (Ka) and Ig (sub)isotypes by Surface Plasmon Resonance (SPR) in two particular clinical cases of individuals with severe episodes of impaired glycemia. Subject 1 suffers from brittle diabetes associated with circulating insulin antibodies (IA) due to insulin treatment. Subject 2 has insulin autoantibodies (IAA) associated with hypoglycemia in spite of not being diabetic and not having ever received exogenous insulin therapy...
2013: PloS One
https://www.readbyqxmd.com/read/24095173/-eosinophilic-esophagitis-a-pathology-on-the-rise
#3
M Miranda García, B Gutiérrez Teira
The eosinophilic esofagitis is a pathology that consists of an inflammatory condition of the esophagus, which is characterized for having a high percentage of eosinophils. It is a problem of allergic origin and his diagnosis is increasing in the population, especially in children and adult young persons, throughout last decade. The fisiopathology is not completely established nowadays. The diagnosis is confirmed with endoscopia and capture of biopsies. The differential diagnosis is necessary to be done with the disease for reflux gastroesofágico, gastroenteritis eosinofílica, by Crohn's disease, pathology of connective fabric, syndrome hipereosinofílico, infections and response of hypersensitivity to medicaments...
October 2013: Semergen
https://www.readbyqxmd.com/read/21548197/-pathophysiology-and-treatment-of-bronchectasis
#4
Adina M Turcanu, T Mihăescu
Bronchiectasis is a complex pathology which consists of some important morphopathological changes in the lumen of the bronchi that consecutively determines recurrent pulmonary infections with a diversity of germs. The repeated episodes of infection are associated with chronic colonization of the respiratory system with certain pathogen microorganisms and play an important role in the maintenance of the chronic inflammatory syndrome, as well as the decline of the pulmonary function. This chronic inflammation is represented by a series of fisiopathological changes (the raised number of neutrophiles, macrophages, alteration in the expression of pro-inflammatory cytokine and adhesion molecules)...
January 2011: Pneumologia: Revista Societății Române de Pneumologie
https://www.readbyqxmd.com/read/17067236/-side-effects-of-antiretroviral-therapy-fisiopathology-clinical-manifestations-and-treatment
#5
REVIEW
E Santos Corraliza, A Fuertes Martín
The suppression of plasma viral loads in HIV infected patients to less than the limit of quantification of the most sensitive commercially available assays and the coincident improvement in CD4 T cell counts is associated with a decrease in the risk of new opportunistic infections in this patients. The descent at the morbibility and mortality is specialy important since the introduction in 1996 the hard activity antirretroviral therapy (HAART). However, prolonged treatment with combination regimens can be difficult to sustain because of problems with adherence and toxic effects...
July 2006: Anales de Medicina Interna: Organo Oficial de la Sociedad Española de Medicina Interna
https://www.readbyqxmd.com/read/15789532/-fisiopathology-of-iron-metabolism-diagnostic-and-therapeutic-implications
#6
REVIEW
M Muñoz Gómez, A Campos Garríguez, J A García Erce, G Ramírez Ramírez
No abstract text is available yet for this article.
2005: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/12602009/-intraoperative-awakening-report-of-a-case-in-pediatric-surgery
#7
E López-Candel, E Cánovas, J López-Candel, R García, J Soler, S Fernández, J P Hernández, J Vargas
Intraoperatory awakening or awareness can be defined as recovering of conscience during general anesthesia. We report such a case happened in a 11 year-old boy during a hypospadias repair. After anesthetic education he related intraoperatory conscience without pain, anxiety, displeasing symptoms or long-term psychoconductal distress. We remark fisiopathology, diagnostic and preventive aspects of this rare event in pediatric surgery.
April 2000: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
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