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https://www.readbyqxmd.com/read/29036957/-a-meta-analysis-of-randomized-controlled-trials-of-bismuth-containing-quadruple-therapy-combined-with-probiotic-supplement-for-eradication-of-helicobacter-pylori
#1
X B Si, Y Lan, L Qiao
Objective: The bismuth containing quadruple therapy (BCQT) acts as first-line therapy in China. Probiotics supplement also shows Helicobacter pylori eradication effects. Adding probiotics along with BCQT may improve eradication rate of Helicobacter pylori. Methods: Electronic databases including Medline, Embase, Wanfang Database, etc. were searched by the established searching strategy. After that, a funnel plot was adopted to evaluate publication bias. The meta-analysis was supplemented in fixed effect model for low heterogeneity and randomized effect model for high heterogeneity conversely...
October 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29036901/importance-of-leadership-style-towards-quality-of-care-measures-in-healthcare-settings-a-systematic-review
#2
REVIEW
Danae F Sfantou, Aggelos Laliotis, Athina E Patelarou, Dimitra Sifaki-Pistolla, Michail Matalliotakis, Evridiki Patelarou
Effective leadership of healthcare professionals is critical for strengthening quality and integration of care. This study aimed to assess whether there exist an association between different leadership styles and healthcare quality measures. The search was performed in the Medline (National Library of Medicine, PubMed interface) and EMBASE databases for the time period 2004-2015. The research question that guided this review was posed as: "Is there any relationship between leadership style in healthcare settings and quality of care?" Eighteen articles were found relevant to our research question...
October 14, 2017: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/29036866/the-prevalence-of-occupational-musculoskeletal-disorders-in-iran-a-meta-analysis-study
#3
Ayub Parno, Kourosh Sayehmiri, Mohsen Parno, Mohammad Khandan, Mohsen Poursadeghiyan, Maryam Maghsoudipour, Mohammad Hossein Ebrahimi
BACKGROUND: Prevention of Work-Related Musculoskeletal Disorders (WRMSDs) is crucial as they jeopardize the well-being of the workforce in workplaces and are prevalent in developed and developing countries. OBJECTIVE: This study aimed to determine the prevalence of WRMSDs among Iranian workers. METHODS: A systematic review and meta-analysis of WRMSDs in Iran was performed by searching relevant keywords in authentic databases and search engines such as SID, Google Scholar, Medlib and PubMed...
October 8, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/29036720/the-relationship-between-clinical-and-personal-recovery-in-patients-with-schizophrenia-spectrum-disorders-a-systematic-review-and-meta-analysis
#4
Robin Michael Van Eck, Thijs Jan Burger, Astrid Vellinga, Frederike Schirmbeck, Lieuwe de Haan
Patients describe experiencing personal recovery despite ongoing symptoms of psychosis. The aim of the current research was to perform a meta-analysis investigating the relationship between clinical and personal recovery in patients with schizophrenia spectrum disorders. A comprehensive OvidSP database search was performed to identify relevant studies. Correlation coefficients of the relationship between clinical and personal recovery were retrieved from primary studies. Meta-analyses were performed, calculating mean weighted effect sizes for the association between clinical and personal recovery, hope, and empowerment...
July 14, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29036684/yeastract-an-upgraded-database-for-the-analysis-of-transcription-regulatory-networks-in-saccharomyces-cerevisiae
#5
Miguel C Teixeira, Pedro T Monteiro, Margarida Palma, Catarina Costa, Cláudia P Godinho, Pedro Pais, Mafalda Cavalheiro, Miguel Antunes, Alexandre Lemos, Tiago Pedreira, Isabel Sá-Correia
The YEAst Search for Transcriptional Regulators And Consensus Tracking (YEASTRACT-www.yeastract.com) information system has been, for 11 years, a key tool for the analysis and prediction of transcription regulatory associations at the gene and genomic levels in Saccharomyces cerevisiae. Since its last update in June 2017, YEASTRACT includes approximately 163000 regulatory associations between transcription factors (TF) and target genes in S. cerevisiae, based on more than 1600 bibliographic references; it also includes 247 specific DNA binding consensus recognized by 113 TFs...
September 25, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29036683/cr2cancer-a-database-for-chromatin-regulators-in-human-cancer
#6
Beibei Ru, Jianlong Sun, Yin Tong, Ching Ngar Wong, Aditi Chandra, Acacia Tsz So Tang, Larry Ka Yue Chow, Wai Lam Wun, Zarina Levitskaya, Jiangwen Zhang
Chromatin regulators (CRs) can dynamically modulate chromatin architecture to epigenetically regulate gene expression in response to intrinsic and extrinsic signalling cues. Somatic alterations or misexpression of CRs might reprogram the epigenomic landscape of chromatin, which in turn lead to a wide range of common diseases, notably cancer. Here, we present CR2Cancer, a comprehensive annotation and visualization database for CRs in human cancer constructed by high throughput data analysis and literature mining...
October 3, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29036623/predictors-of-mortality-in-high-risk-patients-with-qt-prolongation-in-a-community-hospital
#7
Charlotte Gibbs, Jacob Thalamus, Kristian Heldal, Øystein Lunde Holla, Kristina H Haugaa, Jan Hysing
Aims: To determine predictors of mortality in patients with corrected QT interval (QTc) ≥ 500 ms in a community hospital. Methods and results: In this retrospective observational study, we searched the electrocardiogram (ECG) database at Telemark Hospital Trust, Norway, from January 2004 to December 2014. Medication, electrolyte abnormalities, and medical conditions known to prolong the QT interval were recorded. From the medical records, we assessed whether the prolonged QTc was noted by the health care providers...
October 3, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29036542/database-resources-of-the-big-data-center-in-2018
#8
(no author information available yet)
The BIG Data Center at Beijing Institute of Genomics (BIG) of the Chinese Academy of Sciences provides freely open access to a suite of database resources in support of worldwide research activities in both academia and industry. With the vast amounts of omics data generated at ever-greater scales and rates, the BIG Data Center is continually expanding, updating and enriching its core database resources through big-data integration and value-added curation, including BioCode (a repository archiving bioinformatics tool codes), BioProject (a biological project library), BioSample (a biological sample library), Genome Sequence Archive (GSA, a data repository for archiving raw sequence reads), Genome Warehouse (GWH, a centralized resource housing genome-scale data), Genome Variation Map (GVM, a public repository of genome variations), Gene Expression Nebulas (GEN, a database of gene expression profiles based on RNA-Seq data), Methylation Bank (MethBank, an integrated databank of DNA methylomes), and Science Wikis (a series of biological knowledge wikis for community annotations)...
October 3, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29036527/isyte-2-0-a-database-for-expression-based-gene-discovery-in-the-eye
#9
Atul Kakrana, Andrian Yang, Deepti Anand, Djordje Djordjevic, Deepti Ramachandruni, Abhyudai Singh, Hongzhan Huang, Joshua W K Ho, Salil A Lachke
Although successful in identifying new cataract-linked genes, the previous version of the database iSyTE (integrated Systems Tool for Eye gene discovery) was based on expression information on just three mouse lens stages and was functionally limited to visualization by only UCSC-Genome Browser tracks. To increase its efficacy, here we provide an enhanced iSyTE version 2.0 (URL: http://research.bioinformatics.udel.edu/iSyTE) based on well-curated, comprehensive genome-level lens expression data as a one-stop portal for the effective visualization and analysis of candidate genes in lens development and disease...
September 19, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29036469/burn-pain-a-systematic-and-critical-review-of-epidemiology-pathophysiology-and-treatment
#10
Michael Morgan, Jennifer R Deuis, Majbrit Frøsig-Jørgensen, Richard J Lewis, Peter J Cabot, Paul D Gray, Irina Vetter
Objective: This review aims to examine the available literature on the epidemiology, pathophysiology, and treatment of burn-induced pain. Methods: A search was conducted on the epidemiology of burn injury and treatment of burn pain utilizing the database Medline, and all relevant articles were systemically reviewed. In addition, a critical review was performed on the pathophysiology of burn pain and animal models of burn pain. Results: The search on the epidemiology of burn injury yielded a total of 163 publications of interest, 72 of which fit the inclusion/exclusion criteria, with no publications providing epidemiological data on burn injury pain management outcomes...
September 23, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29036324/pancanqtl-systematic-identification-of-cis-eqtls-and-trans-eqtls-in-33-cancer-types
#11
Jing Gong, Shufang Mei, Chunjie Liu, Yu Xiang, Youqiong Ye, Zhao Zhang, Jing Feng, Renyan Liu, Lixia Diao, An-Yuan Guo, Xiaoping Miao, Leng Han
Expression quantitative trait locus (eQTL) analysis, which links variations in gene expression to genotypes, is essential to understanding gene regulation and to interpreting disease-associated loci. Currently identified eQTLs are mainly in samples of blood and other normal tissues. However, no database comprehensively provides eQTLs in large number of cancer samples. Using the genotype and expression data of 9196 tumor samples in 33 cancer types from The Cancer Genome Atlas (TCGA), we identified 5 606 570 eQTL-gene pairs in the cis-eQTL analysis and 231 210 eQTL-gene pairs in the trans-eQTL analysis...
September 25, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29036298/myvcf-a-desktop-application-for-high-throughput-mutations-data-management
#12
Alessandro Pietrelli, Luca Valenti
Summary: Next-generation sequencing technologies have become the most powerful tool to discover genetic variants associated with human diseases. Although the dramatic reductions in the costs facilitate the use in the wet-lab and clinics, the huge amount of data generated renders their management by non-expert researchers and physicians extremely difficult. Therefore, there is an urgent need of novel approaches and tools aimed at getting the 'end-users' closer to the sequencing data, facilitating the access by non-bioinformaticians, and to speed-up the functional interpretation of genetic variants...
July 24, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29036199/the-acute-physiological-stress-response-to-driving-a-systematic-review
#13
Michael Antoun, Kate M Edwards, Joanna Sweeting, Ding Ding
BACKGROUND: The experience of driving has been suggested to be detrimental to health. One hypothesis is that each exposure elicits an acute stress response, and that repeated exposures may act as a chronic stressor. OBJECTIVE: The aim of this review is to evaluate and synthesise the evidence on whether driving elicits an acute physiological stress response. METHODS: Electronic databases, including CINAHL, PsycINFO and Medline, were searched for original articles written in English from database inception until March 2016...
2017: PloS One
https://www.readbyqxmd.com/read/29035966/effectiveness-of-rifampicin-chemoprophylaxis-in-preventing-leprosy-in-patient-contacts-a-systematic-review-of-quantitative-and-qualitative-evidence
#14
Silvana Margarida Benevides Ferreira, Tatiana Yonekura, Eliane Ignotti, Larissa Bertacchini de Oliveira, Juliana Takahashi, Cassia Baldini Soares
BACKGROUND: Individuals in contact with patients who have leprosy have an increased risk of disease exposure, which reinforces the need for chemoprophylactic measures, such as the use of rifampicin. OBJECTIVES: The objective of the review was to synthesize the best available evidence regarding the effectiveness of rifampicin chemoprophylaxis for contacts with patients with leprosy, and to synthesize the best available evidence on the experience and acceptability of rifampicin chemoprophylaxis as reported by the contacts and health professionals involved in the treatment of leprosy or Hansen's disease...
October 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29035965/effectiveness-of-bedrails-in-preventing-falls-among-hospitalized-older-adults-a-systematic-review
#15
Paulo Marques, Carmen Queirós, João Apóstolo, Daniela Cardoso
BACKGROUND: Falls are a major problem today affecting adults of any age, but the elderly are a population that is more susceptible to falls. Falls are the leading cause of injury or death among older adults. Hospitalized older people are particularly vulnerable to falls. Falls cause direct injuries (minor injuries, severe wounds of the soft tissues and bone fractures) to patients and increased length of stay. The prevention of falls is commonly considered an indicator of the quality of care...
October 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29035943/metabolic-syndrome-and-subclinical-carotid-damage-a-meta-analysis-from-population-based-studies
#16
Cesare Cuspidi, Carla Sala, Fabio Provenzano, Marijana Tadic, Elisa Gherbesi, Guido Grassi, Giuseppe Mancia
AIM: Metabolic syndrome (MetS) is a phenotype of growing prevalence in the general population. Information on the association between MetS and vascular damage in this setting is only based on data provided by single reports. We performed a meta-analysis of population-based studies aimed to assess the association of MetS with carotid atherosclerosis. DESIGN: Studies were identified by the following search terms: 'metabolic syndrome', 'general population,' 'carotid intima-media thickness' (IMT), 'carotid atherosclerosis,' 'carotid damage,' 'ultrasonography...
October 13, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29035801/systematic-review-with-meta-analysis-performance-of-dried-blood-spots-for-hepatitis-c%C3%A2-antibodies-detection
#17
REVIEW
B A Muzembo, N C Mbendi, S F Nakayama
OBJECTIVES: Dried blood spots (DBS) specimens can be used for hepatitis C virus (HCV) infection screening in cases where serum specimens are difficult to obtain. However, uncertainties surround the sensitivity and specificity of DBS for HCV antibodies (anti-HCV) serology testing. We aimed to evaluate the accuracy of DBS use to screen for HCV infection. STUDY DESIGN: We carried out a systematic review and meta-analysis. METHODS: Medline and EMBASE databases were searched for articles published between 1989 and November 2016...
October 13, 2017: Public Health
https://www.readbyqxmd.com/read/29035773/first-irish-and-tenth-case-of-small-bowel-obstruction-secondary-to-suprapubic-catheterisation-in-the-world-case-report-and-case-review-of-a-rare-complication-of-suprapubic-catheterisation
#18
Yasir Bashir, Quart Ul Ain, Muhammad Jouda, Osama Al Sahaf
INTRODUCTION: Percutaneous Suprapubic urinary bladder catheterisation (SPC) is a common procedure performed in cases of urinary retention where attempt to pass urethral catheter has failed. However, the procedure requires meticulous precision, vigilance and sound knowledge of anatomy, to avoid grave complications. We are reporting a very rare complication of Suprapubic catheterisation that is small bowel obstruction. Our case is first Irish and 10th global case of small bowel obstruction secondary to SPC...
October 10, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29035733/how-does-parental-cancer-affect-adolescent-and-young-adult-offspring-a-systematic-review
#19
REVIEW
Adam Walczak, Fiona McDonald, Pandora Patterson, Katherine Dobinson, Kimberley Allison
OBJECTIVES: To i) identify and synthesise evidence published since 2007 regarding the impact of parental cancer on adolescent and young adult offspring, ii) identify methodological and evidence gaps addressed during this period and iii) highlight those requiring further attention. DESIGN: A systematic review and thematic synthesis of peer reviewed literature regarding the impact of parental cancer upon AYA offspring. DATA SOURCES: Online searches of CINAHL, Embase, Medline, PsychInfo and Scopus databases were conducted...
September 1, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29035708/an-assessment-of-the-utilization-of-the-preclinical-rodent-model-literature-in-clinical-trials-of-putative-therapeutics-for-the-treatment-of-alcohol-use-disorders
#20
Ashley M Barajaz, Christopher L Kliethermes
OBJECTIVE: Rodent models of Alcohol Use Disorders (AUD) are used extensively by preclinical researchers to develop new therapeutics for the treatment of AUD. Although these models play an important role in the development of novel, targeted therapeutics, their role in bringing therapeutics to clinical trials is unclear, as off-label use of existing medications not approved for the treatment of AUD is commonly seen in the clinic and clinical trials. METHOD: In the current study, we used the Clinicaltrials...
October 12, 2017: Drug and Alcohol Dependence
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