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https://www.readbyqxmd.com/read/29245184/evaluation-of-the-use-of-novel-biomarkers-to-augment-antimicrobial-stewardship-program-activities
#1
Kayla R Stover, Rachel M Kenney, Travis S King, Alan E Gross
As antimicrobial stewardship increasingly receives worldwide attention for improving patient care by optimizing antimicrobial therapy, programs are evaluating new tools that may augment antimicrobial stewardship activities. Biomarkers are objective, accurate, and reproducible measures that provide information about medical conditions. A systematic literature search using PubMed/MEDLINE databases was performed to evaluate the use of novel biomarkers as additions to the antimicrobial stewardship armamentarium...
December 15, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/29245141/a-systematic-review-of-the-state-of-the-literature-on-sexually-exploited-boys-internationally
#2
Melissa Moynihan, Katherine Mitchell, Claire Pitcher, Farinaz Havaei, Max Ferguson, Elizabeth Saewyc
This systematic review assessed the current state of the literature on sexually exploited boys internationally. We aimed to describe what is known about sexual exploitation of boys, identify gaps in the literature, provide implications for practice, and make recommendations for future research. Multiple database searches were conducted using a combination of controlled vocabulary and keywords to capture child and adolescent sexual exploitation. Our search identified 11,099 unique references and excluded studies that did not include male participants less than 18 years old or disaggregate results by relevant age groups and/or by sex...
December 12, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29244989/global-use-of-traditional-and-complementary-medicine-in-childhood-cancer-a-systematic-review
#3
Caroline Diorio, Catherine G Lam, Elena J Ladas, Festus Njuguna, Glenn M Afungchwi, Katherine Taromina, Stacey Marjerrison
Purpose Traditional and complementary medicine (T&CM) strategies are commonly used in pediatric oncology. Patterns may vary based on country income. We systematically reviewed published studies describing T&CM use among pediatric oncology patients in low-income countries (LIC/LMIC), middle-income countries (UMIC), and high-income countries (HIC). Objectives included describing estimated prevalence of use, reasons for use, perceived effectiveness, modalities used, rates of disclosure, and reporting of delayed or abandoned treatment...
December 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29244953/metaqsar-an-integrated-database-engine-to-manage-and-analyze-metabolic-data
#4
Alessandro Pedretti, Angelica Mazzolari, Giulio Vistoli, Bernard Testa
The study describes the MetaQSAR tool, a new database engine specifically tailored to collect and analyze metabolic data. This is a plug-in embedded in the VEGA suite of programs (freely downloadable at www.vegazz.net) and takes advantage from all cheminformatics features implemented in the software with additional tools aimed to perform statistical analyses, similarity searches and physicochemical profiling of the stored molecules. MetaQSAR also implements a novel metabolism classification, which groups the metabolic reactions in 101 classes and can find numerous applications in metabolic analyses...
December 15, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29244893/effectiveness-of-intra-articular-injections-of-sodium-hyaluronate-or-corticosteroids-for-intracapsular-temporomandibular-disorders-a-systematic-review-and-meta-analysis
#5
Marlon A Moldez, Victor R Camones, Guillermo E Ramos, Mariela Padilla, Reyes Enciso
AIMS: To assess the effectiveness of intra-articular injections of sodium hyaluronate (NaH) or corticosteroids (CS) for treatment of intracapsular temporomandibular disorders (TMD). METHODS: Single- or double-blinded randomized controlled trials (RCTs) on the effectiveness of NaH or CS injections, compared to each other or to placebo, for the treatment of intracapsular TMD due to osteoarthritis and/or internal joint derangement were analyzed in this systematic review and meta-analysis...
December 15, 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/29244823/cost-effectiveness-of-national-health-insurance-programs-in-high-income-countries-a-systematic-review
#6
Son Nghiem, Nicholas Graves, Adrian Barnett, Catherine Haden
OBJECTIVES: National health insurance is now common in most developed countries. This study reviews the evidence and synthesizes the cost-effectiveness information for national health insurance or disability insurance programs across high-income countries. DATA SOURCES: A literature search using health, economics and systematic review electronic databases (PubMed, Embase, Medline, Econlit, RepEc, Cochrane library and Campbell library), was conducted from April to October 2015...
2017: PloS One
https://www.readbyqxmd.com/read/29244792/tight-glycemic-control-in-critically-ill-pediatric-patients-a-meta-analysis-and-systematic-review-of-randomized-controlled-trials
#7
Yiyang Zhao, Yang Wu, Bo Xiang
BACKGROUND: There still are controversies in the impact of tight glycemic control (TGC) in critically ill children. The aim of this study was to assess the benefits and risks of TGC compared with conventional glycemic control (CGC) in critically ill pediatric patients admitted to the pediatric intensive care unit (PICU) by using data retrieved from randomized controlled trials (RCTs). METHOD: EMBASE, CNKI, PubMed and the Cochrane Database were searched for RCTs comparing TGC with CGC in critically ill children in PICU...
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29244536/dietary-intake-of-fish-n-3-polyunsaturated-fatty-acids-and-risk-of-hip-fracture-a-systematic-review-and-meta-analysis-on-observational-studies
#8
Omid Sadeghi, Kurosh Djafarian, Sima Ghorabi, Mahmoud Khodadost, Morteza Nasiri, Sakineh Shab-Bidar
Previous studies have shown that fish consumption and dietary intake of n-3 polyunsaturated fatty acids (n-3 PUFAs) are associated with hip fracture; however, findings were conflicting. The present review aimed to summarize the current evidence on the association of fish consumption and dietary intake of n-3 PUFAs with hip fracture. The online databases of PubMed, ISI Web of Science, Scopus, ProQuest, Science Direct and Embase were searched until August 2017 for related publications using relevant keywords...
December 15, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29244533/systematic-overview-of-neuroanatomical-differences-in-adhd-definitive-evidence
#9
Bruno Bastos Vieira de Melo, Maria João Trigueiro, Pedro Pereira Rodrigues
OBJECTIVES: This article seeks to identify neuroanatomical differences in ADHD through an overview of systematic reviews that report encephalic differences compared to a control group in volume, area, activation likelihood or chemical composition. METHODS: We conducted a systematic search using Cochrane guidelines and PRISMA criteria in PubMed, Scopus, Web of Science, Cochrane Database of Systematic Reviews and Database of Abstracts of Reviews of Effects. RESULTS: Results revealed broad encephalic involvement that includes a functional frontal and cingulate hypoactivation and structural differences in corpus callosum, cerebellum and basal nuclei...
December 15, 2017: Developmental Neuropsychology
https://www.readbyqxmd.com/read/29244099/the-role-of-vitamin-d-in-adipogenesis
#10
Clare F Dix, Johanna L Barcley, Olivia R L Wright
Vitamin D, a secosteroid predominately obtained by endogenous production, has in recent years been linked to obesity and its comorbidities. The purpose of this review is to draw conclusions from animal and human studies on the effects of vitamin D on adipogenesis to identify the molecular links between vitamin D and obesity. The information presented herein was obtained from 4 databases (PubMed, CINAHL, Cochrane Library, Scopus) using predefined search terms, as well as research literature and other reviews...
December 13, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/29244060/the-residual-medium-and-long-term-cognitive-effects-of-benzodiazepine-use-an-updated-meta-analysis
#11
Simon F Crowe, Elizabeth K Stranks
Objective: This study presents an updated meta-analysis of the effects of benzodiazepines on cognitive functioning in long-term, current users of these agents, those who have recently withdrawn and on those who have successfully abstained following withdrawal. The study represents an update of the previous meta-analyses published by our group. Method: A comprehensive search of the computerized databases Medline and PsycINFO was undertaken to identify studies that assessed the cognitive effects of benzodiazepines published up to 28 November 2016 (the date of the last update)...
December 13, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29243995/the-relationship-of-erectile-dysfunction-and-subclinical-cardiovascular-disease-a-systematic-review-and-meta-analysis
#12
Chukwuemeka U Osondu, Bryan Vo, Ebenezer T Oni, Michael J Blaha, Emir Veledar, Theodore Feldman, Arthur S Agatston, Khurram Nasir, Ehimen C Aneni
Erectile dysfunction (ED) is associated with cardiovascular disease (CVD) and CVD mortality. However, the relationship between ED and subclinical CVD is less clear. We synthesized the available data on the association of ED and measures of subclinical CVD. We searched multiple databases for published literature on studies examining the association of ED and measures of subclinical CVD across four domains: endothelial dysfunction measured by flow-mediated dilation (FMD), carotid intima-media thickness (cIMT), coronary artery calcification (CAC), and other measures of vascular function such as the ankle-brachial index, toe-brachial index, and pulse wave velocity...
December 1, 2017: Vascular Medicine
https://www.readbyqxmd.com/read/29243880/review-article-best-practice-management-of-common-knee-injuries-in-the-emergency-department-part-3-of-the-musculoskeletal-injuries-rapid-review-series
#13
REVIEW
Kirsten Strudwick, Megan McPhee, Anthony Bell, Melinda Martin-Khan, Trevor Russell
Knee injuries are a common presentation to the ED and are often difficult to assess and definitively diagnose due to the patient's acute pain, effusion and guarding. The quality of ED care provided to patients with fractures or soft tissue injuries of the knee is critical to ensure the best possible outcomes for the patient. This rapid review investigated best practice for the assessment and management of common knee injuries in the ED. Databases were searched in 2017, including PubMed, CINAHL, EMBASE, TRIP and the grey literature, including relevant organisational websites...
December 15, 2017: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/29243848/analgesic-efficacy-of-preoperative-dexketoprofen-trometamol-a-systematic-review-and-meta-analysis
#14
Vicente Esparza-Villalpando, Amaury Pozos-Guillén, David Masuoka-Ito, César Gaitán-Fonseca, Daniel Chavarría-Bolaños
Post-Market Research Clinical evidence supports the use of dexketoprofen trometamol (DEX) to manage acute postoperative pain. However, controversies surround the impact of the use of this drug in preoperative analgesic protocols. The aim of the present meta-analysis was to evaluate the effectiveness of the preoperative administration of DEX under postoperative pain conditions. Electronic and manual searches were conducted through diverse electronic databases. A systematic review and meta-analysis to evaluate the analgesic efficacy of the preoperative administration of DEX was performed including Randomized Clinical Trials (RCTs) published between 2002 and 2017...
December 15, 2017: Drug Development Research
https://www.readbyqxmd.com/read/29243813/antiepileptic-drug-monotherapy-for-epilepsy-a-network-meta-analysis-of-individual-participant-data
#15
REVIEW
Sarah J Nevitt, Maria Sudell, Jennifer Weston, Catrin Tudur Smith, Anthony G Marson
BACKGROUND: Epilepsy is a common neurological condition with a worldwide prevalence of around 1%. Approximately 60% to 70% of people with epilepsy will achieve a longer-term remission from seizures, and most achieve that remission shortly after starting antiepileptic drug treatment. Most people with epilepsy are treated with a single antiepileptic drug (monotherapy) and current guidelines from the National Institute for Health and Care Excellence (NICE) in the United Kingdom for adults and children recommend carbamazepine or lamotrigine as first-line treatment for partial onset seizures and sodium valproate for generalised onset seizures; however a range of other antiepileptic drug (AED) treatments are available, and evidence is needed regarding their comparative effectiveness in order to inform treatment choices...
December 15, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29243804/notalgia-paresthetica-a-review-for-dermatologists
#16
REVIEW
Matthew Howard, Lukas Sahhar, Frank Andrews, Ralph Bergman, Douglas Gin
Notalgia paresthetica (NP) is an underdiagnosed condition that presents with unilateral pruritus medial to the scapula on the midback with or without an associated hyperpigmented or hypopigmented macule. There is a paucity of recent reviews on this chronic cutaneous neuropathy in peer-reviewed journals. Current theories propose the condition is likely multifactorial, including spinal entrapment and muscular compressive neuropathy. An extensive literature review was performed by searching the MEDLINE database to review all published works on notalgia paresthetica...
December 15, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/29243775/independent-prognostic-factor-of-low-expressed-lncrna-znf667-as1-for-cervical-cancer-and-inhibitory-function-on-the-proliferation-of-cervical-cancer
#17
L-P Zhao, R-H Li, D-M Han, X-Q Zhang, G-X Nian, M-X Wu, Y Feng, L Zhang, Z-G Sun
OBJECTIVE: To investigate the expression of long non-coding RNA ZNF667-AS1 in cervical cancer and its effect on the proliferation of cervical cancer cell line, SiHa cells. MATERIALS AND METHODS: The expression level of ZNF667-AS1 from two microarray datasets (GSE63514 and GSE6791) and TCGA (The Cancer Genome Atlas) were selected to analyze the difference between cervical cancer tissues and normal cervical tissues with bioinformatics methods. Then, the prognosis of ZNF667-AS1 was calculated in TCGA...
December 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29243683/the-comparison-of-cement-and-screw-retained-crowns-from-technical-and-biological-points-of-view
#18
Aira Ragauskaitė, Gediminas Žekonis, Juozas Žilinskas, Alvydas Gleiznys, Eglė Ivanauskienė, Darius Gleiznys
OBJECTIVE: The aim of this review was to evaluate the most common complications in implant prosthodontics with porcelain-fused-to-metal crowns, to evaluate the influence of biomechanical properties on fractures and cracks of veneered porcelain, and to compare the effects of crowns with different connections on soft tissues. MATERIAL AND METHODS: A search of literature in the English language between 2009 and 2015 was conducted using the following databases: Medline via PubMed, Science Direct, Wiley online library, Taylor& Francis, and Cochrane library...
2017: Stomatologija
https://www.readbyqxmd.com/read/29243680/a-review-of-peek-polymer-s-properties-and-its-use-in-prosthodontics
#19
Gediminas Skirbutis, Agnė Dzingutė, Viltė Masiliūnaitė, Gabrielė Šulcaitė, Juozas Žilinskas
OBJECTIVE: The aim of this study is to review polyether ether ketone (PEEK), its characteristics and use in prosthodontics. MATERIAL AND METHODS: Information search for articles about PEEK and it's use in prosthodontics between January 2010 and April 2017 was conducted in Medline via PubMed, Science direct, Wiley online library as well as the Web search Google Scholar sources. Twelve full text articles were selected and used in this review. RESULTS: 143 articles were found in the database using keywords: PEEK, prosthodontics, dentistry...
2017: Stomatologija
https://www.readbyqxmd.com/read/29243572/development-dissemination-and-applications-of-a-new-terminological-resource-the-q-code-taxonomy-for-professional-aspects-of-general-practice-family-medicine
#20
Marc Jamoulle, Melissa Resnick, Julien Grosjean, Ashwin Ittoo, Elena Cardillo, Robert Vander Stichele, Stefan Darmoni, Marc Vanmeerbeek
BACKGROUND: While documentation of clinical aspects of General Practice/Family Medicine (GP/FM) is assured by the International Classification of Primary Care (ICPC), there is no taxonomy for the professional aspects (context and management) of GP/FM. OBJECTIVES: To present the development, dissemination, applications, and resulting face validity of the Q-Codes taxonomy specifically designed to describe contextual features of GP/FM, proposed as an extension to the ICPC...
December 15, 2017: European Journal of General Practice
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